Document reGoRLb992ygaoJaYZgVn3q6q

Cl NO. y- 7 r-j)sc? p:.rt file You]nger Laboratories INCORPORATED 123 CLIFF CAVE ROAD SAINT I.OLMI, MO.. 12t Toxicologic Investigation of: AROCLOR 1016 To: MONSANTO COMPANY Lot Number KS 01->701 St* Louis, Missouri PiojectNo, Y-75-252 Date: October 22nd, 1975 ACUTE ORAL TOXICITY Species Sprague-Dawley Albino Rats LD50 2,350 Mg/Kg 95% Confidence Limits 2 120 - 2,500 Mg/Kg CONDITIONS Single Orel Dose - Undiluted Dotage MgfKg _ ' 1,580 2 2,000 3 2,510 3,160 6 3,980 6 Signs of Intoxication Grots Autopsy Decedents Avg. Initial Weight Male Female 230 235 230 235 235 240 230 220 225 220 Male 1/3 1/2 2/3 2/2 3/3 Morialitiet/Doaed Pamela Combined 0/2 1/5 0/3 1/5 1/2 3/5 2/3 4/5 2/2 5/5 Time of Mortality One to four days, moat within two days Reduced eppetite end activity (one to three days In survivors), Increasing weakness, collapse, and death* Hemorrhagic lungs and liver, and gastrointestinal Inflammation. Survivors ( 14 Days) Viscera appeared normal* ACUTE DERMAL TOXICITY Species New Zealand Albino Rabbits LDso > 1.580 Mg/Kg 95% Confidence Limits CONDITIONS Applied Undiluted Mg/Kg initial Weight* Male Female Male 1 631 2 1,000 3 1,580 4 2,000 6 5,010 e 2.1 -- -- 2.2 2.1 ------ 2.1 1.9 ----- 0/1 ... 0/1 --- 1/1 ... Mg/Kg Mortaiit iec/Doaad Female Combined ... 0/1 0/1 0/1 -- - 0/1 Vi ill -- in Exposure 24 Hours Time o* Mortality Seven days Six days Signs of Intoxicstion Reduced eppetite and activity (two to four days in survivors), Increasing veekneee, collapse, and death. Gross Autopsy Decedents Lung hypercala, liver discoloration, enlarged gall bladder. darkened kidney and epleen, and gastrointestinal inftarnation. Survivors (14 Daytl Viscera appeared normal* HONS 045579 The material In ihl* report la to be uaed in development of the product and may be given to ratponalbla aaiaa contact*, but It la not to ba utad bv them edveHlalng copy. The aourca of thll material la not to bo divulged until It appaart In formal pwbllcatlona. No eNeeotlona to the *i*hi.tb*rt ut* may m mada without the approval of the Medical Department In St. teula. Cuatomari' Inquiriea regarding mattera of tonicity are to be referred at hafor# to me Monaonlo Company Medical Department in St. Uoula for reply. _ project no. Y-75-252 test material AROCLOR 1016 ___________________________ LOT NUMBER ** 01-701 ACUTE EYE IRRITATION luxation Score tj4, 4. 7? Hour i 5*1 Species Classif ication Slight * Oose and Conditions 0.1 HI. Applied Undiluted / F.H.S.A * F.H.S.A,;NOT CLASSEpaa an Eye Irritant Hours Hew Zealand Albino Rabblta Exposure 24 Hour. Aiumol Number 1 2 3 4 6 6 Mean Score IX/110.01 1* \V 0 0 0 0 0 0 ft \ V 0 81 0 0 80 0 10 0 080 0 10 0 080 8.6 ft T \ T 0 12 0 0 10 0 0 10 0 0 12 0 0 12 0 0 12 0 .11 3 ft T \ r 040 0 40 000 0 20 0 20 060 3.0 ft \\ 1* T 060 0 20 000 000 000 0 40 1.0 1ft ^ \ 00 00 00 00 00 00 0.0 0 0 0 0 0 0 0.0 Immediate: Discomfort vaa alight Comments 1Q Mlnuteg. Slight erythema, moderate to copious discharge 1 Hour: Slight erythema, very slight edema in two instances, copious discharge 24 Hours; Slight to moderate erythema, very alight edema, copious discharge containing whitish exudate 48 - 72 Hours: Gradual Improvement 120 Hours: All scored zero PRIMARY SKIN IRRITATION Species Irritation Score (24, 72 Hour av > 5.3 Classification Severe * Oose and Conditions 0.5 Ml. Applied Undiluted / F.H.S.A. * F.H.S.A.: CLASSED at a Primary Skin Irritant New Zealand Albino Rabbits Exposure: 24 Hours _______ __ _ ERYTHEMA Animal HOUR ' Numb*. SKIN '4 ' A 24 A 48 1 A. 72 _l A_ 168 1 .A 4 24 1A 1 A 48 1A 72 1A 168 A 22 22 22 22 22 22 22 22 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 00 00 00 00 00 00 22 22 22 22 22 22 33 33 33 33 33 33 22 22 22 22 22 22 22 22 22 22 22 22 00 00 00 00 00 00 Comments Moderate defatting effect - akin sloughed off in ten to fourteen daye. There wee no Injury In depth. INHALATION TOXICITY Mortality .................... Concentration.............. Exposure ....... Sample temperature... Signs of Intoxication Grow Autopsy Decadents Survivors ( Days) Mg/L Ht! c Initial sample.......... .. Recovered sample.... Condensed sample .. Vaporized sample... . Species 9 9 9 9 Chamber temperature . . . Chamber humidity........... Chamber volume............. Air flow rate...................... MQNS 045580 c % L l/Mi Test Method Reference A.T.S. 8/73 Submitted b MELVIN D. BIRCH Young* r L\horatori*s.1nc.