Document rQGoMgpvrMwJE6YR573qeEd0

MONSANTO COMPANY o Organic Chemicals Division Applied Sciences Section 11/2/70 o MEETING MINUTES Environmental Aroclor Project; PCB Analysis of Industrial Bio-Test Laboratories Tissues Monsanto General Offices Medical Department St. Louis, Missouri September 21, 1970 Copies tos _>R. E. Keller W. B. Papageorge W. R. Richard E. S. Tucker E. P. Wheeler FP- The above attendees reviewed the status of all feeding studies currently being carried out by Industrial Bio-Test Laboratories and set priorities and target dates for completion of tissue residue analysis by the Analytical Group of the Applied Sciences section. All tissues on hand as of 6/2/70 are listed in the following table. I. Chicken Study A. Eggs - pooled samples from control 1, 10, and 100 ppm exposure levels ^60 samples 1. Pre-batch collection 2. Hatch collection .3. Recovery - 1st week 4 Recovery - 2nd week 5. Recovery - 3rd week 6. Recovery - 4th week B. Tissues - pooled M&F samples of fat, liver, kidney and muscle from control, 1, 10, and 100 ppm exposure levels ^80 samples. 1. Sacrifice at exposure termination 2. Sacrifice at end of recovery period C. Chicks - pooled samples, whole - I samples? 1. Survivors 2. Mortalities HONS 030243 o Q2 - II. Rat Reproduction Study A. Pups - whole - # samples? 1. Each group first utter, 1st generation III. Chronic Rat Study . Pooled M&F samples of fat, liver, kidney, and muscle from control, 1, 10, and 100 ppm exposure levels MO samples per sacrifice. A. Sacrifices completed 1. 3 months 2. 6 months 3. 12 months IV. Fish Exposures - 96 hr. - TLm A. Whole fish and water samples 'v-194 samples It was agreed that residue analysis of these tissues should proceed in the following order. ' Number Man-Months Tentative Target Date III. II. IV. I. Chronic Rats Rat Reproduction Fish Chicken Study 1.5-2.0 ? 4.0-6.0 3.0-4.0 8.5-12.0 1/71 1/71 6/71 9/71 E. S. Tucker db 1 HONS 030244