Document rBwp4jRre6Z32wGOjZyErqLoq

September 2, 1958 Mr. Charles J. DeSimone Senior Industrial Hygienist Speoial Health Services Pratt & Whitney Aircraft East Hartford 6, Connecticut Dear Mr. DeSimone1 Thank you for your letter of August 26 requesting toxiolty information on Pydraul AC. In animal toxicity screening studies with this product, the oral lethal dose in rats is approximately 40 grams per kilo- " gran and in rabbits, 3*5 to 4.3 grams per kilogram. The greater sensitivity of rabbits is typical of this type of fluid. This lethal dose is of suoh an order, however, that in either oase the fluid may be considered only "slightly toxlo" to man from the standpoint of accidental ingestion of single doses. The fluid may be absorbed through the unbroken skin of rabbits in quantities resulting in death, but again the minimum lethal dose (4.0 to 3*0 grams per kilogram) is suoh that aooldental massive skin exposures to man do not present a hazard. Rats survived a 6-hour exposure to an atmosphere saturated with vapors of the fluid. Skin and eye irritation studies with rabbits developed numerical Boores whioh classify the fluid as a mild Irritant. The studies with animals, however, do not indicate the moderately severe pain whioh man experiences if there is accidental oontact with eye tissues. In the instances whefe there has been acci dental splashing in the eyes, reports indicate "burning" or pain out of proportion to the amount of temporary injury to eye tissues. Neither in the oase of animal studies nor in the in stances of human eye exposures has there been any permanent damage to eye tissues. If there is aooldental oontaot with the eyes, we recommend copious and prolonged washing of the eyes with water. To relieve irritations physioIans have used X% pontooalne solution as well as ophthalmic cortisone aoetate medloation. DSW 01868? STLCOPCB4005231 Mr, Charles J. DeSimone--Page 2--September 2, 195Q Pydraul AC may exert a solvent aotion on the skin and we therefore recommend that excessive, prolonged and repeated skin oontaot be avoided to prevent defatting of the skin. Except for the Injury to eyes indicated above, we know of no toxlolty problem whloh has arisen with Pydraul AO, A copy of our Pydraul AC bulletin is enolosed for your information. If I oan be of any further assistanoe, please let me know. Very truly yours. SPWtdh Enclosure 1 Elmer P. Wheeler Assistant Dlreetor Medloal Department DSW 018688 STLCOPCB4005232