Document rBpD0x91ww6OKpgGzYJe4pV5V

ICI Chemicals and Polymers Group Occupational Health Department Hillhouse Site P.O. Box 4 Thornton-Cleveleys Blackpool FY5 4QD Telephone Facsimile (0253) 861632 Direct Line (0253) 861370 Secretary (0253) 861444 Switchboard (0253) 864687 Telex 67483 ICIPLH G To all recipients of the ASL Register C Chemicals and Polymers Group P Hillhouse Site Your ret Our ref BB/feG Date Feb 1987 Dear Colleague RESEARCH INTO ASL I am enclosing the latest edition of the ASL Register, dated February 1987, and am writing to ask for your co-operation with some research into ASL. While in the States recently, I visited Professor Carlo Tamburro, Professor of Medicine & Community Health; Acting Chairman, Department of Community Health; Chief, Division of Occupational Health; Director, Liver Research Centre, University of Louisville, Kentucky. We discussed VC clustering, and why some particular Plants, which have been manufacturing VCM/FVC pre-1962, have never had a case of ASL. As a result of our discussions, we had the feeling that, for ASL to develop, certain circumstances are required, and that a co-factor may be need d. I was wondering if you would be prepared to help in identifying such a factor? I am enclosing a pro-forma with certain chemicals mentioned, and I should be very grateful - if you are willing - if you would tick off the years in which any of the chemicals listed was used, if in fact they were used at all, and return the form to me. I would definitely communicate back to you with any results obtained, and with what conclusions Professor Tamburro and I have made. Before, however, releasing any information with reference to any of th completed questionnaires, I will contact the individual who is responsible for that questionnaire, in order to discuss that information further, and t s ek an appropriate, acceptable way forward, i It should be remembered that this exercise is purely a research topic, and therefore may yield no positive results. I look forward to hearing from you and receiving your comments. Yours sincerely B BENNETT M.A. M.B., B.Ch., B.a.O. D.Obst.R.C.O.G. D.I.H., M.F.O.M ir^i ou 0*0. K* ' __ /"u - CMA 006481 RESEARCH INTO ASL Name of Company*: (*If Company ownership has changed, please give name of previous Company and date of change.) Address: **VrT^^** V 'V*-V Site Location: .............. Form completed by:.............. (Block capitals, please) X";* * * *'+ *<** * *, - > a- e * * w - %T * - - . 1 t- r w p-'^w Date YEAR | VINYL | VINYL I HEXANE I DIETHYLj PHENOL I BUTADIENE I TOLUENE I ACRYLATES 1 CHLORIDE I ACETATE I__________IMALEATEI I______________ j______________ |_____________ 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 J_ _ _ _ _ L 1952 J_ _ _ _ _ L 1953 1954 1955 1 1956 1957 1958 1959 /C ntinued WPX/ASL - RESEARCH,! cMA 006482 RESEARCH INTO ASL Page 2 YEAR 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 VINYL | VINYL !HEXANE j DIETHYL| pHENOL I BUTADIENE I TOLUENE !ACRYLATES CHLORIDE | ACETATE |__________ |MALEATE| 1______________ I______________ I______________ L Please return to: Dr Brian Bennett Occupational Health Department ICI Chemicals & Polymers Group Hillhouse Site PO Box 4 Thornton-Cleveleys BLACKPOOL FY5 4QD ENGLAND UPX/ASL - RESEARCH,2 j tO jj "S j ri CMA 006483 LIVER ANGIOSARCOMA CASES OONFIDBrtTAL CTRCULATICN OF REGISTER BAGSHAW DrIMM BAM) Dr P R BARNES Jnr W C BARR Dr J T BARRAT Dr G BAXTER Dr Peter BAYLAC Dr BEAUPRE M BELLEC Dr BENECH Dr M BEMETT Dr B RFETA77.T Dr P BESCHE Dr BISKS' Dr C BORRELLI F E BOXER R W BRYSON Dr D D BURGESS Mr David BYFEN Dr David CARTER Dr J T QUA Mr C CHANCE Mr M CLAUS Mr P G CLAYTON Mr H OONIASSOT Dr J C DAVIES Mr J G DEPLAN Dr DE VOS Mr A J DIEIZ Dr H W DOLL Sir Richard DOMBROW3CI S L DUPONT Mr G EMONGER Mr H ERNST Dr W EVAIB Dr A E J FALK, Dr H FAVRE Dr FERGUSON Dr D M FORMAN Dr D ERASE R U FRIEDEL Dr H P GCLBERG Prof L QOSZTONYI Jnr Dr GCfTIESlAN R T HARRIS Dr W D HILL Dr G B HILLMAN Dr D W HINDEKER Dr R K HDGG Dr W A FBWARD Dr J K HUMPHRY Dr N F JAUVERT Mr J JERVIS Mr H R JOfES Dr R D Norsk Hydro, Newton Aycliffe, IK Cancer Control Agency of British Colunbia, Varcouver, Qanjria Monsanto, St Louis, Missouri, USA Air Products, Allentown, Pa, USA AECRP, Conmenrry, France University of Cambridge, IK Atochem, Chauny, France Government of Quebec Cancer Registry, Canada Rhone Poulenc, Aubervlllers, France Naphtachimie, Lavera, France Id Hillhouse, UK Inst of Occupational Health, Milan University, Italy Dynamlt Nobel, Trolsdorf, Germany EMAS, Cardiff, IK Georgia Gulf, Delaware City, USA Formosa Plastics, Delaware City, USA IC1 Billingfram, IK ICl Americas, Wilmington, Delaware USA Krmanord, Stockholm, Sweden EMAS, London, IK Enichan Pollmerl, Milan, Italy cO'% ICI Runcorn, IK APME, Brussels, Belgius Norsk Hydro, Newton Aycliffe, l Atochem, Saint-Fons, France ICI, Everberg, Belgian Atochem, Jarrle, France EVC, Welwyn Garden City, UK B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Fund, Oxford University, IK Dew Chemical, Midland, Michigan, USA AM, Brussels, Ro1gdmi VKE, Frankfurt, Germaiy Berufsgenossenschaft der Chemischen Industries, Nurnberg, Germany Lever Bros, Warrington, IK Chronic Diseases Dlv, US Dept of Health & Honan Services, Atlanta, USA Atochem, Montluel, France Id Anericas, Wilmington, Delaware, USA Imperial Cancer Research Fund, Oxford University, IK DiversiTech General, Akron, Ohio, USA Berufsgenossenschaft der Chemischen Indietries, Heidelberg, Gemany Duke UrrLv Medical Center, Durham, North Carolina, USA R E Tenneco Chemicals, Plscataway, Nor Jersey, USA The Vinyl Institute, Wayne, NJ, USA Uniroyal Inc, Middlebury, Connecticut, USA Alberta Cancer Board, Edmonton, Canada Diamond Shamrock Corp, Dallas, Texas, USA BF Goodrich, Cleveland, Ohio, USA Imperial Oil Ltd, Sarnia, Ontario, Canada University of Otago School of Medicine, Wellington, New Zealand Id Australia, Melbourne, Australia Chloe Chtmie, Paris, France Id Ml 11bank, London UK EMAS, Bootle, IK WPX/ASL - ASL ADDRESS,! CMA 006484 2- - KARKH Dr Bruce KORSGAABD Dr K J KREUGER Dr R A LAGAST Dr H LALODE Dr J P LANLAM Dr John LANOUZIERE Dr LAWRENCE Mr J LAWRENCE-JONES LEE Dr F I LELBACH Prof WK LEVEQUE Dr G IEVIS0N Dr D A LEWIS Dr P LOUVIER Mr LUSSATO Dr J MAHLARD Dr J M MALLDIRA Anna MALOTI Prof C MARGETIS, Mr R J MATIRE Prof Lo MATTIUSSI Dr R MOTLEOT D MXKA Mr MOMESAND Dr R M3TTI Dr A A MUNDZ MDUOT Dr M MacSWEEN Prof RNM NAKAMURA S OLSON H G CHEN Dr R PADDLE Dr G M PAGUALUNGA Dr S PAQUET Dr PA3ERSCN Dr J C PIRASIU Dr Roberta POWER Dr Hans POSSBERG Dr J FUECH Dr A M PURDHAM Dr J RAMBAUD Dr J RANGNES P RICHARD Dr P ROBSON Mrs D RODRIGUES Dr MJF ROUSH Dr G RUTY Dr J SALG Dr J SARAGCI Dr R SCHEFFERS Dr M L SCHEFFER Dr H SERONLE Dr D SHAH Dr Has SIGRIST Dr J SMITH Dr E SMITH Dr P M SMITH Prof Allan H SMITH Mr J S SPIRTAS Dr R STAFFORD Dr J STAHNECXER Mr Dupont, WUjningtcn, Delaware USA Norsk Hydro, Porsgrurm, Norway BF Goodrich, Akron, Ohio, USA Solvay, Brussels, Belgium Solvay, Brussels, Belgian Dew Chemical, Midland, Michigan, USA Solvay, Tavaux, France SFI, New York, USA Sir Christopher, Chief Medical Officer, ICI, London UK Victoria Hospital, Blackpool, Lancs, IK University of Boon, West Germany CDF Chlnrie, AZF, Bully-les-Mines, France St Bartholomew's Hospital, London, IK Chemical Industries Association, London, IK Solvay, Brussels, Belgian Atochem, France Suva, Luzern, Switzerland Statistics Canada, Ottawa Institute dl Oncologia, Bologna, Italy ICI Directorate, Wilton HQ, UK Medil-Anic-S, Milan, Italy Montedison, Milan, Italy Norsk Hydro, Newton Aycliffe, IK f.OSJL A sP-1 G.u V-' Neste Oy, Espoo, Finland IARC, Lyons, France Duperial SAIC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese EVC Association, Tokyo VC Safety Association, Louisiana, USA Trades Union Congress, London, UK ICI Central Medical Group, Alderley Park, IK Montedison, Novara, Italy Atochem, Serquigny, France ICI Runcorn, tK Istituto Superiore di Sanita, Rome, Italy Mount Sinai Medical Center, New York, USA Wacker-Chemie, Munich, Germany Atochem, Brlgnoud, France Canadian Centre for Occupational Health & Safety, Hamilton, Canada RP Rechetubes, Antony, France Norsk Hydro, Poregrunn, Norway Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Id, Sao Paulo, Brazil Monsanto, St Louis, Missouri, USA Atochem, St Auban, France NIOSH, Cincinnati, USA IARC, Lyons, France DSM/CVM), Geleen, Holland University of Manitoba, Winnipeg, Canada Diamond Shamrock, Dallas, USA CMA, Washington DC, USA Shell Chinde, Bene L'Etang, France Division of Envirormental Health, World Health Organisation, Geneva, Switzerland Llandough Hospital, Penarth, UK University of California, Berkeley, USA Id Hillhouse, UK NCI/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwlgshafen, Germany CMft 006485 WPX/ASL - ASL ALDRESS.2 TAMBURRO Prof 01 ten EERGE Dr W F UMOCFF Dr N TER HAAR Dr Gary TESWIESCH Dr B THERIAULT Dr Gilles THIESS Prof Dr A M THIIS-EVENSEN Dr E THDMSCN Dr D H TOKDOIR Dr W VAN DER MERWE Dr WALLACE J R WALTEMAIE H WEJDLING S 0 WHEELER Dr D J WHEELER R N WHITE K H WHINSKI 0 WnilAfE Dr DMJ WILSON Prof R WRIGHT Dr A P YORK J -3- University of Louisville, USA DSM, Geleen, Holland Huls AG, Marl, Germany Ethyl Corporation, Baton Rouge, Louisiana, USA Chemisehe Werke Huls, Kreis Recklinghausen, Germany McGill University, Montreal, Canada BASF, Ludwigshhafen, Germany Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, tE, Canada Shell, An Den Haag, Holland H J AECI, Sasolburg, South Africa Esso, Sarnia, Ontario, Canada BF Goodrich, Cleveland, Ohio, Usa Norsk Hydro, Stenungsund, Sweden ICI Hillhouse, Ut Union Carbide, South Charleston, USA Duperial, Buenoe Aires, Argentina Electrochemical Industries, Acre, Israel BP Chemicals, Penarth, IK Harvard University, Cartridge, Massachusetts, USA ICl Wilton, IK ICI Everberg, Belgian From: Dr B Barnett, Occupational Health Department, ICl Chemicals & Polymers Group, Hillhouse Site, PO Bax 4, Thomtcxi-Cleveleys, Blackpool FY5 4Cp, England February 1987 C,^ T t0v s* > v V\ .^v WPX/ASL - ASL ADDRESS,3 CMA 006486 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1987 PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1. The 10 new ca6es in the Register are the following: France 19, 20, 21; Germany 28, 29, 30, 31, 32; UK 13; USA 39* 2. There are amendments from the previous Register against the following cases: France 13; Germany 23, 26. 3- I would like to thank the following for informing me of new cases - Dr Contassot, Dr Barrat, Dr Landers, Dr Friedel, Dr Williams and Mr John E Ertel. 4. For the case corrections I thank Dr Contassot and Dr Friedel. 5. For other corrections and information thanks to Mr John T Barr, Mr John E Ertel, Mr R T Gottesman, Mr A King and Dr N A Sulaiman. 6. I should be very grateful if all recipients of the Register could continue to keep me fully informed of any new cases or, if they hear of other Companies who have acquired a case of ASL, it would be much appreciated if I could be notified by the appropriate person. It is very helpful if new information is supplied in tabulated form, using the headings in the Register as far as possible. For this purpose I have added a blank form at the back of the Register. 7. I would also be glad of help to keep the mailing li6t correct, with news of retirements and successors, etc. 8. Research: (a) I am enclosing a letter which explains a research project in which I and Professor Carlo Tamburro hope you will be able to co-operate in the interest of knowledge. (b) I shall be very grateful if all individuals involved in research or surveys could keep me informed and if possible send me cop^is when they become available. From: Dr Brian Bennett Occupational Health Department ICI Chemicals & Polymers Group Hillhouse Site P 0 Box 4 Thornton-Cleveleys Blackpool FY5 4QD England February 1987 CMA 006487 c\ \ ... v=\a V : ,;v V, ^ t. y>: ICI CHEMICALS & POLYMERS GROUP WPX/ASO - LANGIOCASES,4 Index Table Sequence Belgium Canada Czechoslovakia France Germany I taly Japan N& % o V,. i . rt> fy1 v o- Norway Sweden UK USA Y'- V, C* V < \v V V* \ Yugoslavia Incidence of Cases per annum (Table 1) Distribution of Cases by Country (Table 2) LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1987) Page 1 2-3 4 5-9 10-15 16 17 18 19 20-23 24-30 31 32 33 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Australasian PVC Producers - Start-up Dates (Table 14) Middle Eastern PVC Producers - Start-up Dates (Table 15) Page 44 45 46 47+48 49 50 51 52 53 54 Pattern of Cases by Factory (Table 3) 34 Blank form for notifying new cases CMA 0 0 6 4 8 8 Latency Periods (Table 4A) 35 Distribution of Latency Periods (Tables 4B-4H) 36-42 Annual Geographical Incidence (Table 5) 43 ***' I Hi I.I.HW COUNTRY AND RiE'hRKNCE NO NAME OR I NITlAES RATE OP BERTH 01 12.01.13 Solvay 29 09 40 Solvay o 3: > o o cr> 4* CO 'O IU CHEMICALS 6 POLYMERS CROUP LIVER Angl i>arcnRS Cases - {Review Date : I January (987) WHX/ASI, - IANI.LOCASiS.fi FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS Jemeppe 00.07.Sft 00.OS.76 63 %L Vv: o V v VV... v,- ' Ct C{ r' V*. V *PP* 20 Oft 62 00.10.79 39 YEARS OF EXPOSURE TO DIAGNOSIS 10 LO YEARS OF EXPOSURE DATE Or DEATH 29.06.76 23 10 03 HISTOLOGICAL CONFIRMATION 1( 11 1 14 1 1 5 1 1 1 ESTIMATED | EXPOSURE | OCCUPATION | OTHER CAREER 1 | UlHMt | COMMENTS LEVEL 1 1 HIGHLIGHTS 1 11 11 11 High 11 (Autocleaner |Driller In a (Hepatic tests 116 yr. (foundry |In Oct 1974 mo-1960 1 1(2 yr*) exposed to|Polyworker f Fa rae r (were noraa1. |Ret 1 red 200 ppa 13 yr. for 0 hr* 1 per day and 1 1 certainly 1 under 1 500 Pfm 1 In 6 to 1 9a1 1 1(13 yr.) (Work in glass |lnd. 4 cheat|cal Industry (Feb 1975 (Hoeplta If sed |May 1976 1 (Coaplete |Cl inical and Icareer delaf1 |are Riven In |paper by autoc tavea | IHublet et al 1960-1972 1 exposed to| (In Arch. Helg |Med. Soc., SO-700 ppa | |Hyg. Med. 0 tire per 1 day In 1 23a3 1 (Trav. Med. H-eg11977 pages autoclavesf 1972-1974 \ exposed to| 30-200 ppa{ In auto- 1 1601-622 1 1 1 ( clave rooal nu-too 1 1 1 PR* 1 1975- 50 1 1 1 ppa 1 RETIRED 1 1 Feb 19751 1 I 1 00.62-01. 63 01.67 -10.71 200 pp 1 I |Autocleaner |FIreaan sInce 15 yre 5 at ha |I0 71. |Operator (3 yra 9athB. 1 1 |1at sLgn JnJ y (79: Thoracic Ipaln 07.79. (HepatIr tesla fth/day \ laltered (0.79. 04.63-12. 1 1 Positive 66 < 200 \ (echography ppa 1 J 111.79. Hepa| tec tony 0 7.HII. 1 (Cheauiherapy. 1 (InfuraHt1 on 1 iRlven Lu 1 lletter 12 Nov 1 j | 9((4 i mm l>r 1 | lie SLnovei . C(V f^'1'jort (o To'-. I AN AJ>A Sheet | O"0'-vr in l. 37 `f 1U UIEMILALS A POLYMERS i.HOUr ' 1' -`na LIVER Angfosarcone (^nes - (Review Date: I Ian I9H7> All dales use lih s y s i era DAY - MONTH - YEAR WPX/ASI - |.AN(. |Ot ASK S J COimiHY AND KEhEKENCE NO NAME OR INITIALS DATE OF BIRTH 15.12.13 SHAW1N1GAN FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONKIRKATION _|_I KSTLMATED | EXPOSURE | OCCUPATION LEVEL | I OTIIKH CAREEN HIGHLIGHTS OTHER COMMENTS 1944 1955 41 n 02.09.55 |Reactor Icleaner Operator polymerlaatIon 1 02 1 1 i 1 1 01 1 1 1 | 1 04 1 1 1 1 ! I 05 i I I I I 06 i 1 i i l 07 I I I I l OR i i 1 i 09 I i i i i 106.01.1* | 11 11 11 11 126.00.19 | 11 11 11 11 105.04.19 I 11 11 11 11 ii in?.05.n i 11 Il ll 1l 115.11.19 | 11 11 11 11 109.11.19 | 11 11 11 11 111.05.10 | 11 11 11 119.07.21 | 11 11 11 ii i i i i 11 i i i 1961 i 1957 i 43 i 14 i 14 (21.12.57 | Ye. | ii i i i i 11 1 ii i i i i 11 1 |Maintenance |al1lurlght, IplpefItter 1 |Operator 1 1 1 |Worked (overt taie |Smoker ii i i i i 1t 1 i ii i i t i ii 1 i i 1941 i 1962 i 42 i 21 i 20 111.01.61 1 Ye. | ii i i i i 11 1 ii i t i i 11 1 ii i i i i 11 1 (Operator, |foreman ! \ 1 1 ( J 1 | Worked |overt 1m | Non-smoker j 1i i i i i 11 1 P1 1 i 1945 i 1967 i 40 i 22 i 22 111.01.69 1 Yea I pReactor |Operator, (Worked 1i i t i i 11 P pc leaner (1 oreman, (overtlae 1i i i i i 11 1\ (water cooling |Smoker 1i i i i i 11 PP (uni t 1 1i i i i i 11 1 ____________ i_______________ j 1 ii i i i i 11 i P1 i i 1944 i I960 i 57 i 24 i 05 105.07.69 1 Ye. | ii i t i i 11 1 (Reactor |c leaner IWater cooling |Worked (uni t (overtIne ii i i i i 11 11 1 |Smoker ii i i i i 11 1 ____________ i_______________ j j ii i i i i 11 11 P 1 i i 1947 t 1971 i 51 i 24 i 23 110.06.71 1 Ye. | |Reactor | Ma 1 ntena nee , |Worked * ii i i i i 11 1 Icleaner |ml1Ivrlght (overtIne ii i i i i 11 1 ( |Snoker ii i i i i 11 1 ____________ i_______________ j j ti i t i 1 11 1 P1 1 i 1946 i 1972 t 53 i 26 \ 25 116.11.72 | Ye. | (Reactor |Machine shop |Worked Pi i i i 1 11 1 |cleaner (operator and InvertIne 1i i i i 1i i i i 1 11 1 11 11 (poly unit 1 ____________ _______________ j | Smok e r ( i1 i i i t 11 1 i 1 1961 i 1973 i 53 i 12 1 05 111.06.71 | Yea | i\ i i i 1 11 1 P |Reactor |cleaner 1 (Maintenance |machine shop 1 |In pi ant 125 yrsl Smoker i1 i i *1 1 1 1 1 11 1 11 1 ____________i________________j 1P 1 1 1 1946 1 1974 1 53 1 28 1 26 106.09.76 | Yea p (Furnace op. I 11 1 1 1 1 11 1 |plpel liter 1 1( 1 1 1 1 11 P (salntenanee 1 1f | [ 1 1 11 1 J 1 1 (Worked (overtIne | Smoker j Paper hy m i- Iil-I.ORMI- In Anna lea tl Anatonfe pat hoi oglque Pari a. 1970 Vol 21 No 2 pp!05- 114 cla B th a case had both a hepatoma and ASL simultaneously. CMA 006490 Vm*e 1 CANADA Sheet ? Cl CHEMICALS A POLYMERS CROUP LIVER tagtoaarcoaa Caeca - (Review Date: 1 Jan 1987} PAY - MONTH - YEAR All datea use UK eyate* WPX/ASC I.ANCIOCASK S ,H 1 COUNTRY AND REFERENCE NO i CANADA 10 2 | 11 4 t 5 6 7 i8| 9 10 \ 1 J_ 1 !1 1 1 NAME OR t DATE OF 1 INITIALS 1 BIRTH 1 COMPANY 1i i I 1 i1 1 i riRST VC i DATE OF I ACE AT | YEARS OF t YEARS OF \ DATE OF 1 FACTORY t EXPOSURE i DIAGNOSIS DIAGNOSIS t EXPOSURE TO EXPOSURE | DEATH i \i I i DIAGNOSIS t i \I 1i i 1 it 1i 1 it 1t 16.05.15 \ 1 1953 1976 61 1 23 1 14 (00.04.77 i ii I1 1 1 1i i l i ii J_ _L _L -L L _L j 12 HISTOLOGICAL CONFIRMATION Yea i i n 1 14 1 15 11 11 ESTIMATED 1 | EXPOSURE 1 OCCUPATION | OTHER CAREER LEVEL 1 | HIGHLIGHTS 11 11 11 |Reactor 1 (Furnace op. |eleaner lealntenance. 1 1 packaging 1J 1 l* 1 1 | OTHER | COMHI-NIS 1 1 1 1 (Ex-staoher 1 1 1 O 1 I T6fr900 Vwo Pane 4 CmitOSI OVAKIA 1 Cl CM KM I CALS h POLYMERS CROUP VCR Angiosarcoma Cases - (Review Date: ] Fan 07) UPX/ASL - I.ANCIOCASI S ,9 COUNTRY AMO REFERENCE NO NAME OR INITIALS DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTtIP K COHHKNI Cr.ECHOSLO- Hovaky 01.07.57 24.12.73 45 06.07.27 State Co Hovaky 01.II.SO 27.11.64 37 kf) V L-' \O' \ ...\ V\ -A rf . \v 24.12.73 IS 26.11.64 Autoclave Cleaner lARC letter of I-4-B2 giving details f roa Prof A David of Centre Ind Hygiene and Occ diseases. _1_ Autoclave Cle 1**C letter of l-*-8J g.ve somewhat altered dates for this case. I have accepted the changes since the dates coae f roa Prof A David of the Centre of Industrial Hygiene and Occupetlonal Diseases. My dates coae originally from KIOSH. _L & lP o 3: > oo 0- <1 M Ian-' * l-KANt E Sheet I Vn ~~ l-'io a, Jf-to 0* ** -i Colyss? f n:i CHEMICALS 4 POLYMERS GROUP Live ft Anglosarcnaa Cases - (Review Date: Jan 67) WPX/AM. - I.ANClOCASE S, I f) 4 ' r2 |1 1 1 t OIIHTHV AND I NAME OR | DATE OF REFERENCE 1 INITIALS 1 BIRTH Wtl { 1 FRANCE 1 1 4 COMPANY ii 15i 1! t1 11 | FACTORY I 1l 11 1I \1 01 IN (15.04.24 Rr i |Rouse- 11 | 11 loti I 1 {1 1 il il il 02 | SIM 1 1 |01. 06.II FCUK i1 1I IRrlgnoud I 11 1 1P i 1 11 i1 11 1I iI r 01 | NAV 11 1 106.01.20 RP i i | St Pona 1t 1 iI 11 1 iI iI 1i 04 1 HDR J___________ _L {t 127.01.27 i PCI)It t 1t |Brtgnood 1 ii i 1) i1 1 1i 11 1 1I 1\ i1 05 I 29.01.M FCUK |Brlgnoud 1 1I 1 1i iI 1I o1 3: P >{ 1 { 1 1 1 o1 o1 o- 1 A1 1 1 {1 i1 'O |i iI w _]___________ 6 ! FIRST VC EXPOSURE 1 00.01.46 I 06.07.5V [ 00.00.46 1 l. 10.49 I ia.0l.6i | 7 DATE OF DIAGNOSIS i ! 18.02.67 I I I I li.0l.7J I I I I I 15.01.75 l I I I I 16.01.76 ( 1 I I I I I I 13.05.76 I l I I l I ) 1 1 1 I 1 I | A ACE AT DIAGNOSIS 43 i i i i i 63 p p i i 55 1 t i i i i i 1 49 i i i * 3B i i 1 i p i 1 i i 1 1 9 LO i n 12 i YEARS OF EXPOSURE TO DIAGNOSIS I YEARS OF [ date of EXPOSURE | DEATH \ HISTOLOGICAL CONFIRMATION 1 1 1 1 21 19 |19.02.67 Yea 1 i i1 i1 ir i i1 16 i U 124.01.75 1 Yea i (HIOSH no i CMMIlt) ii t 11 11 i1 i| i1 29 t 29 129.06.75 Yea 1 t i1 ii i1 p i i1 I! ti 26 26 106.01.76 Yea i i1 1) 1l 1I 1I 1I i PI i 1t 1 1 11 lll.0J.76 l Tea i 1I 1t i1 iP 1I 11 i i 11 1 11 i 1 1I \ 1I 1 11 i 1 1 -iL J|___________ i_I 11 1 3 J >4 1 15 1 16 11 11 ESTIMATED 1 | EXPOSURE | OCCUPATION j OTHER CAREEH | OTHER | COMMENTS LEVEL 1 1 HIGHLIGHTS 11 11 11 High r {Autoclave {worker and Icleiner 1 1 1 1 {Ref. Ravier et {al Arch. Hal. {Prof. 1 10 ns 119 yra 1 13 Nov 75 11 Ip 171-17? 1{ { High 1 |2 yra on { {Italian IRef . laonoaer {origin |C Bonnet on et |10 yra on f polywer|lnation 1 1 1 |a 1 "Nouvel1e Iprease {medicate** 11 {5 Nov 1977 1{ IP 735 11 High 11 1 I Polyworker |VCH productlon|Ref. Hety et |10 yra aa 116 yr. |al Arch. Mai. {autoclave |Italian PON {Prof. 1 17 n' {cleaner |Shepherd, |6 June 7? (Compounding {Sawyer, Ha a on |p 551-555 U yr. r 1{ High 1 {Monomer |product Ion {worker i i i i 18 yr | PVC (filtration i i r 118 yr i High 1 |Polyworker l l (1)Thoracotomy |Ref. P Coudere III yra |9th Feb 1976 |er al "Seaside I {costal {dee hoepltaux { {angiosarcoma 110 Septeabre 1 |2) Scintigraphy!1976 1 (found ASL |Previously hud { |1)Haeaorrhage {hone 1 {from ASL fang losamau 1 imtght {Also 1 (Hepatectoay |PItlrhowakJ et {1 (al "La Nouvk11 * 11 |Presse Med 11 a 1 * {1 |7th Inly 14/v j ________________ fPage 2465 i NANI h Mnv t 2 ICI CHEMICALS 4 PULYKKRS CRUIJP LIVER AnKloHamita Cases - (Review Dale: 1 Jan 1967) UPX/ASL - LA NCI OCASE S , I 1 COUNTRY AND KKEERENCE NAHE OR INITIALS DATE OF 6IRTK 14.04.34 POJJC 1 n? |cir i 1 1 1 t 11 126.04.27 1 ii 1i 1i 1i j RP 01.04.34 Sol Mr 00.10.14 RP n 3 > o .*> >0 X FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRHATION ESTI MATEO EXPOSURE LEVEL OCCUPATION Brlgnoud 01 >03.50 12.00.76 42 18 13 M.09.76 (NIOSH says 12.09.76) (1958-1960) 2 yr# f1lcrat Ion 10-11 yrs polywu rker and works lab? OTHER CAREER HIGHLIGHTS | OTHER | COMMENTS | J_________ I I 1 |This wan had |AOL prior to |AS. Ann. de (Hal. Prol. (July '7? |p 645 6 6. |A0L was found |In 1971 Ilve lyrs before | ASL 1t ) i ISt Auban J 01.07.JO t After i 1i t death i ii | NIOSH 1 i1 1 *r* 1 1i !L | 00.07.76 i 1 j___ *9 Tavaua 23.05.57 03.12.75 42 1 1 26 1 1 1 J-- 19 i t1 i 22 102.07 76 | Yea High 1\ (Plant fore- (1972-6 adaln (Died of i 1 | (NIOSH no (an In (section In (septlrseala i 1 1 cornu) 1 Ipolyacr- (St Auhan |S*al1 liver i 11 1 (last Ion 1 (lesion found i 11 1 (alter autopsy i _______ 1 _l_ -J J j___________________ 1 30.01.77 Moderate 6 yre packer (Had been 6 autoclave (tunnel worker c Inr |prevloualy 14 yre I autoclave worker I J___________ 10.01.40 28 A*; A ,?M . c \f'\ r1 { ,> >, '\ '\ `i? r'Vxx = V- V,,, > 25.12.77 Very High 1948-1966 Leaeer Exposure 1966-1976 Folyaerlsation operator, autocleaner, utoclave alntenance 10 yrs In (Operated 4.2 ft sulphuric |lor reov l at acid factory, |tusiour Inn storekeeper 4 fliver and general Idled after services fsecond f surglcaI loperatlim f |hlllo Ibronclif a I J flat nla (Paper by | Hr Ret y et | I n Ar i h t vei. |Ha ladea ( Prof eaaloM.i | Vo 1 4U No ft I 1979 pages |74l - I. ___________________ !_______________ Rajlr I St.ee I I i^U;i 1 r' r ' n.- fai ca ul cu 11A L "n. I Cn'^ir in J,- -0-4337 '`,j 0n.jrt [Cl CHEMICALS 4 POLYMERS CROUP -Gin 'ana LIVER Ang oaarciiM Cases - (Review Dele: Jan 1987) WPX/ASI - LANUIOCAS1S,l i 10 1 1 ( OIINTHY AND HFKERKNCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FIRST VC UPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEAAS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 24.05.19 St Pou 00.12.54 10.0I.T8 58 10.01.78 5.02.12 IV Sc Foaa 00.01.41 li.0S.7S 66 17 11 11.11.78 High High Autoclave cleaner 10 yra In aechanlcal engineering Induat ry 1944-1956 1941-1946 polymeriaation general purpoae worker 1946-1972 VCM synthesis (NCI 4 Acetylene) Foreman (agent de msltrlae) 1972 retired Died of pulmonary embolism 5 days after surgery _L 12 I6.Q8.14 PCUK tcigooud 09.02.49 00.05.79 65 10 27 21.06.79 High Monomer production and polymer- last Ion 11 19.01.II Solvay TOOT IS.OS.79 40 16 TOOT operator Autoclesner 2 yra as cycle Clgarette I jrr.. mechanic. smoker tint 11 Auto 10 yrs as 1974. Ill all operator ensmeller In of 197/ due in 9 yra. aanltary ware OeaophagM I Copo I yne ra nanuf act it re varices. 4 yra Surglcal I nt er vent 1 mi 25.in.79 (right 05-04-24 Chloe Chlmle St Pona w oo.o7.si TT 38 I9.07.S1 Very High 1941-1975 19*5-1979 1941-1975 All types of mslntensnre hepstect oray) ( Formerly and Jobs on work RP) Internl 11- manufacture ent ly 4 maintenance 1975-1979 In VCM poly Process S 6 fr9 0 0 VW3 ^r - ' r. t-KANCI* Sheet A v , ; .' ... . .' ' . k' r'^i' in '; ./ >! ; ^ -'0-4337 u> ^ ^ C'O'I ('t LIVER Anglosarcooa Canes - (Review Date: l Jan 1967) WPX/AS AN). KM AS> S , I t 1 i OIINTKY AND | REFERENCE 1 NO France 1 2t NAME OR INITIALS 1 \ | | 1 1 ( I 1 DATE OF BIRTH i i < 4 COMPANY 1 f5 6 \ 1 1 FIRST VC | FACTORY i EXPOSURE 1i 1i ii 1t 78 DATE OF ACE AT DIAGNOSIS i DIAGNOSIS p 1 9 10 1 11 1 12 i n 1 14 1 1i 1 YEARS OP YEARS OF| DATE OF EXPOSURE T<>1 EXPOSURE| DEATH i HISTOLOGICAL | ESTIMATED \ CONFIRMATION | EXPOSURE 1 OCCUPATION | DIAGNOSIS ii J LEVEL | i! 1i ii i1 1s OTHER CAREER HIGHLIGHTS 1 1 lh 1 J f OTHER | COMMENTS 1 1 (Left HepAtertnny 1)931 (5 (DEP i 16 1CIM 103.01.37 i Chloe fSt Fone 1 i dilate i i (foraerljr 1 1 RP) 1 ii i ti i 1i 113.07.22 i Chloe 1 i dilate i 1 fSt pone \ 1 i (Formerly 1 1 i RP) 1 1i i ii i 07.07,51 i i i i i t i i 17.10.4) i i i t 28.09.62 05.01.83 i i p i t i i i i p p t 45 61 27 27 |Alive Tea |Hlgh-20 yr |Autoclave r |Moderate Icleaner ip (7 yr. |1955-1962 i 1 | autoclave i 1 (operator iI 1 M962-1982 iI 1 I1 41 38 103.04.83 Yea IHIgh-33 yra |Polymerlaat - iI 1 (Moderate' (ton Proceaa |Low - 5 yra | Han (i 1 1 (Maintenance ) i IHorker |J C Contassot (Letter of 15 10 1981 1 f i \ |Rett red tJan 1979. (J C Contassot (Letters of 10 1983 and |?5 7 84. 17 |HAR i in |R o at > o o ts > <1 (h 11 (i i 1i i 1i t 122.02.23 i Chloe |St Pone i i dilate i I i (Formerly i i i 17.06.4S i i 03.04.S1 i i i i 1 i M>) i i t r ii i * ii t i ii i j ii i i ii i \ i 114.07.42 Solvey i 1 fTavaux tt t i 09.09.63 21.03.84 i i i ii ti i ii i i 1i ti i fi i p 1i 1i 1i 1 1 1p i 1i 1i 1 11 11 11 1 1i i \1 \t 1 _L X 60 47 1 1 IHealth 6 1 i 1 1 Safety Agent) ( i 1 J1 < 1i 1 14 28 103.04.83 Yee P PPtPPh - JAutoclave (Other sectors | Ret 1 red iI m yr. ICleaner lof St Fons I0l.ftl.79 iI \ 11948-1971 (Factory I97|- (.1 C Contassot iI 1 (1978 |Lett er of il 1 |5 10 1983 iI I 1 iI 1 1 ip 1 1 ip 1 1 ii f 1p p 1I 1 21 22 127.12.84 I 7I.03.S4 |Hfgh-)2 yr. |Autoclave iI i PLaw - 9 yr. |Cleaner t 1I ( tI 1 tt 1 J1 11 i1 I\ 1\ i\ I( I 1 1 1 1 ______ 1 1 1 J 109.01.84 1 Right (Hepatect ooy (05.05.64(24.09.84 (chemotherapy (for lungIneteetauls (partial |real as Ion, 108.64 - t tver | recurrence. (10.84 - itrifc: |evolutIon of (the fllaeaHe 1 I'MANf h Sheet 5 rci CM KM f CALS 6 POLYMERS CROUP LIVER Angiosarcoma Cases - {Review Date: I Jan 1967) UPX/ASL - LANi;i(ICAStS,l4 10 n COUNTRY AND REFERENCE WO NAME OR INITIALS DATE OF BIRTH COMPANY FRANCK 19 1 ii 1 1i 1 1i | MAZ | 5.12.32 | Atochea 1 ii 1 1t 1 (i l Li 02.03.23 FACTORY FIRST VC I1POSURI DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF HISTOLOGICAL DEATH CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION ti t ti I ii I Itrlgnoud 01.04.St | 16.10.04 1 1 1 1 52 i 25 \ i1 \ 1i 1 i1 1 25 f06.1t.85 1 i1 1 1 (Autoclave ( 1 (operator and] Yea | High (cleaner | OTHER CAREER HICHLICUTS ( OTHER | COMMENT S 1 I |Myocardla 1 11nf arctIon 11 960.Coroner y (bypass 1961. it 1 $ i ii 1 1 i ti ) 1 i i1 i 1i 1 1I i\ 1\ 11 \ 1 l (letter fros | Dr Contassot (5.4.8b i _L--------------------1 _L_ Irlgnoud 1951 27.12.65 i 34 1 1 J___ 22 26.(2.85 1 _JL__________________ 1___________________ Autoclave In other parte \Portal HtRh operator and of factory Iflbroete fro* cleaner since 1946 126.04.74. The |11Ineaa was (diagnosed as | presissaMy |wark related |on 20.04. 74. | Let ter trim )Dr ContaasiM 105.04.66 1 11 21 I Pa (Ok.10.40 1 ( it l 11 ( \i 1 ii i 11 1 1i i ii i ij 11 1 I i | SEP | itst I 03.06.66 t 45 i ii (MontIucon| i I i ii i l i ii i I i ii t I t ii i I ii i t i ii i 1 i 1L_ _! J_ i i 11 11 1 1 i 4 126.06.66 1 Yea 1 High |Autocleaner (Malnt enance JHepatte test i ii i 14 yeara (worker |Hey 84 norma 1. i ti 1i r (Hepatic teat i ii 11 i |Hay 86 showed i ii i ii 1i 11 1 1 (sbnoraal1 ties. (Letter f ron i it t( i (Dr Rarrst i it (1 i (IB.07.86. ! i j____ i _J j o 3: > o O' 'O si 10 GERMANY Sheet I 1. `Uc^>?u p'. `-.s ; /' in '''< rCo!U't ' J Vr r. "AiJiana I Cl CHEMICALS 6 POLYMERS CROUP LIVER Angioaarcona Cases - (Review Date: l Jan 1987) WPX/ASL - LANGIOCASkS,|S 10 13 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF 6IRTH COMPANY FACTORY FIRST VC IXFOSUtB DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL l OCCUPATION | | OTHER CAREER HIGHLIGHTS 1 | OTHER COMMENTS 1 02 1 1 1 03 1 P 1 i 1 1 i 1 1 i 1 P 1 1 i i i 1 00.00.30 ii 100.00.11 1 1! l\ 100.00.10 I 11 11 11 11 11 11 11 11 11 11 11 i1 t1 t1 11 11 ---------- !------------------- 1 00.00.30 6 12 01.10.36 19.09.68 it i i 6 1 I4.I0.S7 15.09.70 | i 1 1 12 1 1 1 09.06.51 00.03.73 1 t | f1 i i1 11 i1 iP i i i i i1 i i1 11 i i i1 ir 11 i i i ti 1i ii i i i ii t ii i _J i 16.06.57 26.11.76 38 39 4} 66 1 1 | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 .1 12 23.01.69 Yea (NIOSH) Polyworker --. I--t ` i |. M - , | 11 ------ 11 13 i 11 114.11 71 | Ye. (NIOSH) | |Polyvorker 1 i 11 11 1 i 1I 1 21 i 16 110.10 73 |Yea (NIOSH) | i 1i i i 1i i i 11 \ 11 pFIlilng \ (pesticide | laeroeol canal With VC | i 1i i1 1 i 1i i1 1 i 1i i1 P i 1i i1 f i 11 P1 1 i 11 11 1 i 1i i1 1 i 1i i1 ( i ti ii > i 1i ii i i 1i i1 1 i 1( i1 1 i 1t i1 1 i _] ii ii I 17 17 25.1 .76 Tm (NIOSH) 200-500 ppm Polyvorker 6J1956 was but high temporary |eutocleaner during J yr a titoe leaner (for I yr eutocteener 1 1 1 (Reported under |non polyaer|laatinn (workers fn INIOSH list of 131.3.77. (This of course 11 a strictly Icorrect. IHowever 1 |vonder (whether tills lain had high (exposure to |VCM In hi a (can filling (operatIon? i I I Cllnlr.1 Met.l 1 I it I paper by (Coke] et .1 | VI rehows An li |A Path 19/b I1T2 p I9S-JII1 ao: > o o O' 'O 00 Page 11 rf.fi MANY Sheet 2 Cp Tr. JV-. ^ ^ ; -Jaz J ';; - CaJ0r'. 1 ! "';jen iri ^"0'- 4a3Z Js/j r 17 Ccouu>r.j. Jiang ICI CHfcHLCALS & POIYHKRS CROUP LIVER Angiosarcoma Cases - (Review Date: I Jan (987) UPX/ASI. - LANGlOCAStS.'C 1 12 13 L COUNTRY AND J REFERENCE | NO | J 1 NAME OR | INITIALS 1 i DATE OF 8IRTN t 1 1 i Lj i 11 CERHANY 1 11 05 1 (NIOSH glves| as Case 06) | 06 | (00.00.36 P i1 1i 1P 11 P1 t1 11 11 i1 i1 1i ii 11 11 11 i1 11 1| 11 100.00.32 I (HIOSH gives as Case 05) 00.00.26 4 COMPANY 11 7 i 5i 6 t 7 i 8 9 10 1 1 12 13 1 >4 i1 i ii 1 i 1 i i FIRST VC 1 DATE OF i ACE AT 1 TEARS OF t FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS EXPOSURE TO 1 1 YEARS OF 1 OATE OF EXPOSURE 1 DEATH HISTOLOGICAL CONFIRMATION 1 1 ESTIMATED 1 EXPOSURE | OCCUPATION ii i 1 DIAGNOSIS 1 LEVEL 1 ii it ii t i 1 1 1 1 1 ii 1 i 1 1 1 1 II 02.04.60 10.12.73 38 13 05 p 16.(2.74 |Tea (NIOSH) P pBG Cheat e ii ii 1 1 i i ii ii Isay# |"chew!at ry it 1 i 1 iP piaboratorfan ii 1 i 1 it pin the ii i i 1i( i1 i 1 ii 1 i1 1 i1 1 i |Techno(logical i (Research |Department* ii 1 1 1 |(NIOSH aaya \i 1 i 1 ii 1 t 1 ii 1 i ii 1 i 1 1 i1 i i1 ii ii ii ii 1 i1 i laaalatant i |factory Ichealat Iwhlch nay be |wrong ItranalatIon) ii t i ( i 1 1i 1 i 1 i1 i | ti| i1 t ii 1 i t 7 i I6.ll.il 1 00.00.75 i *3 1 1 13 it i 12 109.01.75 i Tea i 1 fPVC - Manu- facture Shift Leader 15 OTHER CAREER HIGHLIGHTS IS.04.S4 I2.II.7S 49 21 21 II,11.75 (NIOSH ays |2> _L PVC Manu facture and all work lacl autocleaning 12 yra {1954-66) Forewan Tech Dev 0 yrs (1967-1975) _L P Ih 1 1 | OTHtK | COMMENTS 1 1 1 |Conf1 reed (Reported under |non-pn] yuer11 sat Ion (workers Hi | NIOSH 11st ot |31.1.77 end |l.78. L dun*t 11 hink this 1h |a correct |cleesIf teal ton |by NIOSH. Die (wan way have (been Involved (In VCN [polymer!sat ton ||n pilot pi ai |or In aa 1 n J plant . 1 1 1 00.00.17 I9.07.S4 06.04.7S 58 20 25.12.75 Polyworker 6 6 *9 0 0 VW3 Page GERMANY Sheet 3 jW-- i . t ^i0o;:; !U :- -i. ^ r ICl CHEMICALS i POLYMERS CROUP .'- O. ^..L^Vcirjliigiotcdu Cases - (Revt Date: l Jan 1987) UPXMSL - LAMCiOCASES.I/ 1 11 \ 1 COUNTRY AND J REFERENCE I NO | GERMANY i P | 21 NAME OR | INITIALS 1 i i 3i i i DATE OF i BIRTH 1 1 i 1 1 09 | 1 1 1 { \ 1 1 1 1 1 10 | (NIOSH gWeaf ae Caie 11) | r i i i l i 11 i (NIOSH gtveel I* Gut 10)1 1 1 1 i 1 12 | 1 1 I 1 1 1 i i Oi 3i >i \ oat o o 100.00.34 1 P 1 i i 1 1 1 i i t 100.00.3ft i i l l i i i i i i 100.00.29 i l i l l i i 1 100.00.3ft l l i i i i i l t p t p i i i 4 i5 ft ------------ 1 ioa i 1 8 1i i\ 9 10 i 12 i ii 1 14 COMPANY i i i 1 FACTORY tt \i FIRST fC | DATE OF ACE AT i YEARS OF SXP0SURC | DIAGNOSIS DIAGNOSIS EXPOSURE TO 1i i1 1 I1 YEARS OF | DATE OF HISTOLOGICAL 1 ESTIMATED \ EXPOSURE 1 DEATH CONFIRMATION | EXPOSURE | OCCUPATION t i 1 i DIAGNOSIS i P \ LEVEL I )i i 1 i i (1 i iI 1 ii 1P i i1 1 11 2 P2 t i i i i 20.02.61 | 16.Oft.7b 41 15 i1 i 1i t 1i i 1i t(i 13 124.03.78 1i i1 1i 1i i ii Yes 1 IHIgh peaks 112 yra poly- 1 {worker loci i |17X auto1 Iclm i {cleaning i (Control rooe i i 1t i 1t P II rr ii t t i1 i i 1i i Pi i1 t 2 12 i i i i 1 01.Ql.6t | 00.01,77 i i i i | 1 1 1 1 1 1 40 i i i i i i i 16 i ti 1 10 107.03.77 i ii i ii i ii iI Yes i1 11 IHIgh peaks 110 yr. poly- i (worker loci i |171 autoi (clave i |cleaning i i 1i i ii Pi i1i i ii ii i i 6 i8 i t t i1i tti 1 1i 10.10.55 | 28.06.77 1 47 i 21 i 1t i 1i 1 1i 1 1i i 1i i ii ii i 1i i 22 128.06.77 i i ii i it i\ i *i i it Yes i i i 1 High 1 1 P P J 1 i 1 (1 fra auto- (clave |cleaser 119 yra llllter (operator it i | i i t1 4 i4 00.00.61 | 00.10.77 t 39 u i tti i1 i 11 I 11 P 11 11 t ii i 1i i 6 107.10.77 i Tes ii i 1i Pi i tt i )i i ii tj 11 I r 1PVC Menu- i (facture i (Autoclave i Iworker for i It yr. I1 i1 i I1 i1 l\ i t1 i1 i1 i P1 iP I1 t{ 1 i1 i1 1 _L J -L _L 1 1 J i1 i1 J JL 15 OTHER CAREER HIGHLIGHTS 1 1 lf> P t { OIHKK | COMMENTS 1 1 1 1 110/78 |Conf1 reed |Average (exposure first |9 yra 15(1 p\m. |occ 1 IKK) pgui. |Neat 3 yrs av, 175 ppa. Last. |yr av 35 ppw P |Average {exposure 11 rat |9 yra (50 ppw. |occ IftfWl prn. (Last yr av (75 ppw. CWH (letter ot (21.04.78 1 1 1 1 1 { 1 1 1 1 ( P 1 P 1 1 1 1 1 1 1 1 I r**v 13 GERMANY Sheet 4 ' ' v, r J. - <V. . `T ;' 1. o.^r\ - ij iOn* _ ICI CKKH1CAI.S & POLYHEKS CROUP /t ' ^vJjJiVER Angiosarcoma Cases - (Review Date: lnrt Jan 1991) WPK/ASL - LANCHICASKS.IH 1 COUNTRY AND REFERENCE NO GERMANY ? ii i1 NAME OR l DATE OF 1 ENITIALS 1 BIRTH 1 11 11 11 11 1 14 (5 (NEOSH gives) this as C.. 11) 1 16 o 3: > o o O' 100.00.14 ( 11 11 1P 1P 11 i1 11 11 i1 r1 i1 i1 ip it i1 i1 it i1 i1 1 \1 i1 i1 i1 11 too.00.29 1 11 i1 11 i! i1 11 11 | joo.oo.2i 1 1 11 1i 1( 11 1t 11 p1 p\ 11 11 11 1p 1\ 1p 1i 4 COMPANY 7 a 4 fl5 1------ ------------- i i | 9 10 1 11 1 12 |n l 14 1 i1 \ 1 | 11 11 P 1 | FIRST VC | DATE OF ACE AT i YEARS OF YEARS OF | DATE OF J HISTOLOGICAL \ ESTIMATED 1 1 1 FACTORY | EXPOSURE | DIAGNOSIS DIAGNOS S I EXPOSURE TO EXPOSURE [ DEATH | CONFIRMATION | EXPOSURE p OCCUPATION 1 1! i 1 DIAGNOSIS 1 11 t LEVEL P 1 15 OTHER CAREER HIGHLIGHTS |\ i1 i 1 \ ! P1 1 1 Pi P1 i1 1 i it P t 1 7 | 00.00,60 | 06.04.70 1 1 63 1 IS l Pi P1 14 119.05.7S 1 Yes i P | P 1 1 i 1 1 1i i 1 1i i1 i ii i 1 ii i( 1 ii i ) (P 1( i ii i 1 l (P 11 1 ii i t l iP 1i P ii tt it ii i i t t I 1 t I it ii i 1 l i (Hot an | i 1 t 1 1 tAngiosarcoma | i 1 1 l i tin his letter | i 1 1 l 1 lot 21 12 81, | 1 1 ii i 11 i 1i i 1i i 1i 1 ii i ii 11 i 1 1i l i i tt p t\ i t\ i ii i i i a i 1 i lt.10.Sl i os.to.fa i1 1 f1 \ \1 i i1 * 11 1 11 1 1 1 1 1 1 1 1 1 1 1 t 1 t 1 1 1 25 1 1 1 1 1 1 l 1 (Hr Frieds 1 1 i 1 l i (said this was | 1 1 l i (a ~Plattenepl~| i i l i |thelksrtInom | 1 1 1 i | Der | 1 P l 1 |Spelserohre* 1 i 1 t It* carclm. | i ( t i (of the P 1 i t |oesophagus) I 1 ( i |not sttrlbut- l P 1 t i lable to VCH 6 \ t 1 1 i loot recognlsedl i 1 l i pas an Induet- | ( i l i trial disease J i 1 I i1 l 25 121.10.78 1 Tern 1i f | 7 | Autoclave P l 1i i (cleaner and P 1< i Iworker. 1 l 1i i IDrlcr t 1i i (operator. ( 1i i ILater shift ( 1i i |1eader i i1 i 1 | i i | 10.01.55 i oi.oi.J4 si 1 1 21 ii |(leibach 1 ii (suspected 1 ii |A5L st 1 11 |Feb 1075 r i1 llspsrotomy)| 1 l ti ii i | t 20 i j07.08.ls 1 Tea ii i | High | Autoclave i r 1 |ASL and \ (worker till 1 ( IHepstocellularl |1964. 1 i 1 |Carcinoma | (Leader and P i i1 1 (master 1 i iP (( 1 i1 i 1 ii ii 1 11 1 J 1P 11 1 i1 ( 1 it i( 1 1I 1 1 1P 11 ( 1r I 1 |P 11 1 1i i ( iP 11 i Ii | P \ 1 i 1i | 11 i( l1 1 t !i 1i \ A | __L !| X j JL || j I _L_ 1 16 1 1 OTHER | COKMhNIS 1 1 1 1 |F W Best (letter of |3fUh June (980 (enclosing data | from |Hr H P Prledel (of SC Cheale |F V geet (letter of |30th June 1980 (enclosing data |f roe pH P Friedel of |BG ChemJe |w(thdrawlng (thla case 1 1 1 P P P 1 1 1 1 |Angiosarcoma |conf1rmed 109/79. Some (detall of this (4 also rases |9. 13, 15, 16 (6 17 given 1n (NRW Report fur | I97R (Anglosarcoma (conf1rmed, (full details |of III ness | a 1 nee Ha r i li 1 1971 Hi**-" In (NRW Ned 1 ns|> |Rep lr I97K. | Dl f t emit (delal1s given (In 'VI |Aa sor1 a t ed (111 hease' liy P l.el hai ti and | Ma rst M 1er ICI9HI) p/I. P*e Jl, GERMANY Sheet 5 X t- , n '' " XXc Sr- '-. -,> Jf f* h:i CHtMlCAj.s t kii.ymkrs croup Anglos arrow* Cases - (Review Date: | j*n 198?) WPX?ASI. - lANCIOCASES,I 4 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH GERMANY 17 4 NKISH gives as Case 15) 00.00.17 19 20 TT 00.00.13 00.00.25 00.00.IS 00.00.13 "54.65.il 'VJa FACTORY FIRST VC UFOSURE DATE OF DIAGNOSIS 01.11.61 IA.0ft.7S 00.00.55 15.ll.i9 IS.I0.S4 oo.oe.J4 14.02.SI 00.0*.so 01.01.62 00.09.79 pronounced illnical liver a pat one) 15.15^1 IB.5ff.il5 ACE AT DIAGNOSIS 41 66 65 66 ~W TEARS OF EXPOSURE TO DIAGNOSIS 16 24 is 14 ]ft TT i? TEARS OF EXPOSURE DATE OF J HISTOLOGICAL DEATH | CONFIRMATION I _______ L 2ft.Oft.7ft | I \ \ 21 is IT _L 25.12.79 I Yes I L 11.01.80 I Ye. | Met aliasing IA5L I J____________ 14.10.SO I Tee IHaeuangio |Endothelioma |of liver with INetaatatei 13 I9.06.ft0 | Yea IHaaunglo (Endothelloaa (of liver with (Metastasis 56.li.il 1----------- -------------IHet..casing 1ASL J__________ ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS i I | 1 1 UTlim CUMHENIS __________________!________________ i High Autoclave worker Autoclave Worker I Ang tosarroBvd (confI rued. IAnnual report (of the North | Rhl ne |WeatphaJla (Medical |Inspectorate |for 1978 Ipages 147-17/ lgIves Inti Idetalls. Vinyl (chloride |dIsease |d I ag nosed 102-02-71, |Oesophageal |v arIres. |Radiuloglia I Iy Icon! 1 naed h< r u Ios teolys1s,, High Autoclave Worker High Autoclave Worker |Dr ftesche (letter of (13-04-82 to |Dr V C K Adana _L |Or Besche lletter of (I 3-04-82 to |Dr V C F Adsns High hirTT Autoclave Worker and worked In drying shop Autoclave Worker |Dr Besche lletter ol 11 3-04-82 to |Dr W C h Ad.. 1 Ctisrgehand , I j Dr Ben. fie subsequently (letter ut Foreman 111-04-82 i. ___________________ | Dr V G h Ati CMA 0 0 6 5 0 2 Page 15 GERMANY Sheet 6 Un. i'o. in 1CI CHKHJCAI.S 4 POLYMERS CROUP --, '*`t ff. 'U? , f ' LIVER Angiosarcoma Cases ( Rev Date: I Jan ISA7> WPX/ASL - I.ANClot ASKS , /11 COUNTRY AND REFERENCE NO NAME OP INITIALS DATE OF BIRTH CF.SHANY 23 24 25 | | 1 1 1 ( 1 I 1 t f 1 I 11 (00.00.27 I 11 11 1J 11 11 11 (00.00.26 | 11 11 11 100.00.11 1 26 1 ( 1 1 1 27 1 26 I 1 ( 1 1 1 1 1 1 1 1 1 1 29 32 (00.00.ii j 11 11 11 1 100.00.28 i |21.1 TT2T1 11 11 11 11 11 r1 11 11 11 1\ 1\ 1\ 00.00.22 00.00.17 00.00.23 on.no.3n nto J 2 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF OEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 11 1 1 8 8 1 1955 1 24.03.79 | 52 1 11 t 1 11 1 1 11 1 1 11 1 1 t1 1 1 11 1 t 8 e 1 1141 I 11.10.82 | si 1 11 1 1 11 1 1 1 i .1 1 8 8 1 I960 j 2e.09.i1r (* f i 1--r"1 1*41 1l 1l 11 i1 4 1 4 ( 1955 (TOO! 1 --sr~ 11 11 11 11 1 18.01.S3| 55 t t 1 1 1 1 Vt 7 1 1 1 1 1 - nsT 10.40 j 1 1 1 1 i 1 1 1 1 1 1 -1 1962 1 1 1 1 1 1 ( 1 1 1 1 ( 1 i.oa.$4 15.02.63 i 1 1 1 1 1 1 1 1 1 1 1 ! 61 61 1 1 1 1 l1 24 1 21 129.09.at 1 11 11 11 11 11 11 n 1 12 128.05.83 | 11 11 21 l ii 1 ii.oi.a1 1 ' ii 28 -__ i-- 1 ~n 1 1 1 1 1 IS ii? .ti.si | 1 1 1 1 I02.01.S4 1 1 1 1 1 ii 1 TT" j25.os.ai 1 1 11 1 11 1 11 1 11 ( 11 1 1( 1 11 1 11 1 (1 1 \1 1 1( ! -J___________ I 19 15.02.84 Yea Yea Yea Y Tea Yea | High (*100 pp) | High (>100 pp.) | High 1 | Cheat atry |Worker 1 1 1 1 1 (Autoclave (Cleaner 1 \ iPolyclave Worker and Autoclave Cleaner 1 | | 1 1 1 1 1 | | 1 1 ( I---( High 1 1 1 1 | High (Polyworker 1 1 1 1. (Autoclave Cleaner till 1972 | High iProceaa | 1 |worker 1947-| 1 |B4 (01.10.401 1 (-31.03.84 1 1 \ PVC product-( 1 (ion, | 1 I,git,tor | 1 !*>. 1 11 1 11 1 (1 1 11 1 11 ( Higti Chest at ry wurker .. 1 \ Pr tmary liepatoce liar (carcinoma; (proliferation of the lalnualodat cells with (sinusoidal ectaala. | Frledel letter 23.J2.t4t>. 1 IProf Eder (Munich) (letter 22~08.B3. (Frledel letter (9.1)4.85. 1 IProf Selatftr (Munich) letter 22.116.81. Frledel tetter 19.04.8*1 r_____________________________ |Chronic hepatlrla, (angloatatosla , a 1 ruibolda | (ectaala. Frledel Letter 123.12.86. t (Lei bach. Frledel letteT I9.04.6S |Annual VCM screening (24.04.85: no complaint. |no abnormality deterred. |1970 two-thlrda (gastrectomy fur nlrers. 11971 Coronary thrombus Is 1 1983 Femora 1 )Implant at Ion 11964 Pulmonary embollx* J a nd pi europneunonl .1. (Landera letters 16.09.85 land 04.02.67. 1 emangIosa rkoma. Frledel letter 21.12.MIk 1951 07.01.80 62 29 25,05.83 Yea High Polyworker Shift leader HaeuangIoaa rkoma, Frledel Letter 21.12.Mb. 1951 30.06.85 61 32 Alive Autuclave rleaner Haemanglnaarkom*. Frledel letter 2 I. I > .Mb. 1955 00.04,85j55 ______________ !______ Alive Po 1ywo rker Autorlave c lea in* r Haervangl oHnrkona. Frl eilel let t ei 2 ). I 0 2 9 0 0 VW3 So- 16 ITALY H i CIIEHI ( AI.S t yui.THKKS i.kuiii' i 'O/* LIVER Angloaarcoaa Cases - (Review Dste: /.'/ i'oj in o^z. t^TT^T *11$ i I Ian I9ft7> WHX/ASL - IANUOI AMS,/I COUNTRY AND REFERENCE NO ITALY 01 (On NIOSH supple mentary 11 st) NAME OR INITIALS DATE OF SIRTH COMPANY FACTORY first VC DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION Hits Venice 00.00.6S 19.04.71 36 16.04.71 tYe* PVC Rag eat ruder OTHER CAREER HIGHLIGHTS OTHER CDKHlNIS Primary tiinoiii ay have been perlrardlmm. Not hoao- geneotie with other cases. n. ii.T9 Montedison Porto Harghera 00.00.57 13.12.72 43 IS 27.12.72 1 03 |VC P 1 1 1 1 1 04 | FB 1 1 1 1 1 i i 1 1 1 11 1i 1 1 1 f14.03.20 | Solvay (Ferrsrs 1 00.01.53 1 I0.07.JS 1 55 | 22 1r i1 1 1 i P1 11 1 1 i 11 i1 P P i 11 11 t 1 i 1 J -J______ J J J_ i It 1t 1i 120.07.37 1 ANIC \ Ravenna i 00.04.59 00.01.01 1 43 i 21 J1 1i 1 1 i 11 ii 1 1 i 11 i1 1 1 i t1 1i 1 1 i 1i ii 1 \1 1i 1 1 *1 ii 1 1 i t1 ii 1 1 i 1i ii 1 1 ii 1i 1 1 i 1 11 | 21 p10.07.75 1 Yes i i1 1 P1 1 11 1 (1 1 1 J_ i 1i i 21 130.03.01 i Yea t ii i iP r iP i ii i ii i 1i i i1 i ii i ti ti 1 11 i ii 1 i1 ________________ 1 iJ 11 115 |G Danes In 19.03.37 | Pi 1i 11 11 11 PAHSAC 1 P i i 1 PW ra IVenlce 1 1 J 1 11 11 11 J______________ _____________ -J_ 1i t 00.00. 67 | 07.03 83 1 46 i i1 11 i1 i1 i i 1 1 i 1 1 16 i P1 i i1 i 1i i -J j___ i 1i i 0 P06.04.63 i i ii 1 1i 1 P1 1 1i 1 1i * See Mat Coni Med t , Lavoro 65 p445,, 1974. Further details In letter fro* Dr Hontesano of 1ARC on Apr! 1 1st 1962. Yes ** Mo see Halt on 1 and Rondinella In Acta Oncologies Vo I | 1980 pages 35 - 49. Polyvorfcer 1 | High 1P \ pAutocleaner \ I 972-5 did | 1 1 1 1 l_ i 1 12 yr. 1 Sery High 1 1 5 yr. p Medium IS yr. (1953-1 a variety of| |6!) Autoclave lobs 1 ** loperator | Including | I 12 yr. (14*1- PVC packing.\ 122JL 1 11 li yr - (Never cleaned P | Mo noose r lautoclavee. P loperator (See paper by 1 ** i pCHIAPPtNO et lNon-amok <m. 120 yra - pal Med Lavoro | Cona used i | Autoclave pVol 6 19021 (little 1 * yr. - Joperator 4 Ipp 555-561 (atcohnl. No | Low |other duties! | AOL. i pin auspena1 |lon polymer-f 1 (lsatlon. P 1 1 1 i i _i * (Hedtum-? P (Area Foreman | I In ease Dept (since 1975. j PJ pRag extruderp 1 1 1 J 1 IS Pag 11a- IHIgh P1967-1975 | | Longa 1 * 1 etc <> 1 pCo**erclal | 1 IDept 1976- | 1 11983 I |2 Aug t 9H\ P 1 ! _J1 1 CHA 006504 * In his letter of 1st April 1982, t>r Hontessno of IAtC ssjrs Japanese Ministry of labour five Date of diagnosis - 21-OB-M Age of diagnosis - 52 Years of exposure - 22 Page 18 NORWAY LIVER Angloearcoaa Cases - (Review Date: t Jan 19B7J WPX/ASL - LANI.JOCASES . i 1 10 n 14 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 21.12.1) Norsk Hpd ro Heroja 00.03.50 21.12.71 56 22 04.0 L. 72 High Foreaan 6 Autoclave supervisor I | I i 1 i 1 1 1 1 1 1 I t J | Conti rued by |Dr ThllalEvanaen nf NH. | At APHK MtK <>l 19 lune I9JB |Mr P Ranjnes Istated that AH |had heen a laeaber ot a | start -up t *aa . | VCM 4 PV( we i i* Jasde In sane (building. The |VCM was nade tf rua arel yl ene ffe A ' J' U' ^, ,, O o' <- 111 . ,O >,. ')?. O V:'1' ci ol'^ . f. h iW'-'lA >},>-? J v- 'i- rJu-* ` V'1' MV/ uI - I \\-J 6V I (i I -j I < -~i '9: \1 fc> \Vk*n 3: > 90S90 * In hlt> letter nf 1st April 1982 Dr Hnntesano of [ARC says In Sweden's National Board of OS Health gives 20-02-70 as date of diagnosis for Case IJI and IS-OS-72 for Case 02. CMA 006507 MX Sheet J i, i < .K *- M i i,ai s # r 1M r. LTVCR Angloaarcooa Cases - (Review Date: I Jan I9BO WPX/ASI. - I.ANCIOl AShS ,S so IIK 2Sht>et Cl CHEMICALS 6 POLYMERS CROUP LEVER Angloaarcoua Caaea - (Review Date: 1 Jan 1987) WPX/ASl. - law.uk:asks,.j** 11 J COUNTRY AMD | REFERENCE | NO UK 21 NAME OR 1 INITIALS 1 1 1 DATE OF 1 BIRTH 1 4 COMPANY OS | JK 110.03.14 BP I 1 1 06 |CEP 07 (RGB \ 1931 1 I 1 BP t i1 126.0*.in 1 BP |S 6l 7 61 9 10 i i 12 11 1 H \1 i 1 FIRST VC ( FACTORY 1 EXPOSURE it i1 1 tarry ob.oi.si 1 DATE OF AGE AT DIAGNOSIS DIAGNOSIS 00.to.79 I l 65 YEARS OF i i YEARS OF | DATE OF EXPOSURE TO EXPOSUAE | DEATH DIAGNOSES i 1 I 20 21 |19.11.79 1 HISTOLOGICAL ESTIMATED 1 CONFIRMATION i EXPOSURE | OCCUPATION LEVEL 1 I |1951-52 11 11 P1 P1 11 11 11 11 11 1 11 l 1 l l l l l l l 1 i1 1 1 1 1 1 1 1i i1 i1 |Polyeleaner |1952-55 1 Latex 11955-60 |Poly floor |1960-64 1 Poly i (Chargehand |1964-70 i 1 Charging i 1operator 1 1 1 1 Itarry 1 P t P 1 Itarry 1 1 1 1962 1 1 1 1 1 T55J 09.01.BO l r 1 t i i *575 ) M.04.16 i do 1 1i i i 18 t 12 109.01.60 i i1 1 ii i ii ij a.2 p 13.06.BO 11970-72 1 Drier loperator 1 |7 yr. (Poly Floor i tOperetor 15 yr. i (Poly Floor i \Polyeleaner 1963-5 Recovery 1965-1971 15 OTHER CAREER HIGHLIGHTS 1 1 I 1 1 1 1 1 1 1 i 1 1 1 1 t I 1 1 1 1 1 1 1 1 1 1 i 1 16 OTHI-R COHMVNIS 06.0S.24 terry 105750' "iTTTTTiT 57 \o A: V," K- ' > O, V- ` v>v : r> <.s\,, '<5*. v* r>' >\ '. IjV .. i<f o AS a 7 O., O `-JJ % n'%~o yA ^ ! yv ^ y 31 i* P2S II.81 | i1 11 i1 11 i1 i1 i1 i1 11 i1 11 11 11 11 I1 1t 11 1I 11 11 11 11950-1950 1500 ppm |1968-1974 1100 pp. 1 1 1 1 [ p 1 1 1 1 1 1 1 1 1 1 1 1 11950-SI |I938-J94A (Autoclave loperator (Motor Mechanic (1948-1950 |1951-1957 |0perator on (Chargeaen t Acet yl ene (autoclave |Product Ion (building |PI ant |1957-1974 (Shift (aupervlaor (autoclave |building - |Never pc leaned lautoclaves |but jsupervlaor* a | Job entalted| (entering (autoclavea (to 1 nape* t (Ihra CMA 0 0 6 5 0 9 Snh <o J Calc, y;;T"- / -l>-4iK>7 p... icu faris^r' iCE Co"*t UK Sheet 1 ' lou^iaii m3 l COUNTRY AND REFERENCE NO UK 09 NAME OR INITIALS DATE OP BIRTH 07.09.29 COWANY FACTORY Barry 10 04.04.47 Barry FIRST VC EXPOSURE 15*02.90 27.04.66 1C1 CHEMICALS & POLYMERS CROUP LIVER Angloearcowa Cases - {Review Date: | Jan 1987) 1 DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS HI YEARS OF ElPOSURE tl DATE OP DEATH 02.03.S3 58 33 01 09 64 37 16 4.2 16.09.64 wpx/asi - i.anclocases,// II I5 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS onim rnHHKNrs fedliwi Polyworker _L 2 year* on Ac rylonitrl I Realn Plant. Also prior to 1990. A years RAF Maintenance. 3 years Motor car palntahop. 2 yeara in Craving Dock. High - 11 Polycleaner onths (900 1966-67. PPM). Low- Spray-drier 16 Month* (50 ppa). .bagger 1967- 66 fedlw - Slow-down 21 Montha stripper (200 pp) operator 1960-70. Heavy goods Informal ton vehlrle driver given In until final 1et t er 11tnea. 16.06.84 trn Dr T) H J 08.05.26 Barry 19.12.69 02.06.65 57 19 16 02.06.69 JT 24.01.37 n 3: > o 0 (S 01 o 16.09.57 01.06.85 46 26 06.12.65 High 1965 -69 fed 69-79 Low 79-62 Polycleaner 1965-66. Service operator 66-69. Poly Operator 69-79. Leading Hand 79-62. Low 1957-59 Spare n. High 59-74 bagging Low 74-85 f loor 1957-59. Autoclave Operator 1959-05 Letter nf 04.06.85 Dr Paul Sotih and letter t 04.06.85 Ur l> H I) hvrtiiit Oesuphageri l haeamrrliage due I o oesoptiAgea I varlres flue i<> Ang t naarc man ol liver Let fer 26.06.85 Dr V I le Va&e 23 IW Shfi*t 4 1CI CHEMICALS 6 POLYMERS CROUP LIVER Angloaarcoaa Csaea - {Review Date : I January 1987) PLASTICS DIVISION WPN/ASU - LANUOCAShSb 11 1 r2 1 i 1 11 ! 11 I COUNTRY AND |NAME OR | DATE OF 1 REFERENCE 1 INITIALS* BIRTH 1 NO 1\ t JL 1 11 11 A i s 1 6 t j 1 8 1 9 1 10 | COMPANY !1t 11 I11 |YEARS OF 1 1 1 |FIRST VC |DATE OF |ACE AT |EKPOSURE |YEARS OF) 1 FACTORY |EXPOSURE |DIAGNOSIS)DIACNOS1S|TO |EXPOSURE) [11 |DIAGNOSIS) ) _L j j________ J1L 11 11 1 12 1n 1 i4 t is | 11 11 (HISTO- 1 DATE OF |LOGICAL |ESTIHATED | 1 |OTHER 1 | DEATH |CONFIRM- |EXPOSURE |OCCUPATION tCAREER | |ATION |LEVEL IHIGHLICHTS) J1 JL )b OTHER COMMENTS UK n | MJ 1 1 ) * 1 1 \ 1 1 ) 102.01 48 |BP J1 1) )1 11 11 11 11 11 1J 11 11 1 tarry 1 1 1 1 1 1 ) 1 1 1 1 1 1966 1 1 1 1 1 1 1 1 1 1 1 I | Jan 66 1 1 1 1 1 1 1 1 1 1 1 | 1 1 1 1 1 1 1 1 1 1 1 17 1 1 1 1 1 1 1 1 1 1 1 1 18 i 102 06.86 Yea 1 1 1 1 1 1 1 1 1 1 1 High Low High |Polycleaner | Moved to 1 Regained welly working actively, unil 11968-69 |Acryloni- |Jen 1986 (Central Itrlle 1 Depot (Plant 11969-70 |unttl left | Polyfloor IBP 1981. |1970-71 (Manager ol 1 |!C 6 SS 1 (Ltd at 1 ICardlff 1 | A! rport 1 (1981-86 o 3: o o 0* I. t;. -:.. p3 ^ rv ^ \ 1 r t Vs b. c i Cr- Page USA Sheet I c.-n. in -4 f3t37 n;i CHEMICALS 6 POLYMERS CROUP LIVER Angloaarrnma Casea - (Review Date: l Jan I9fl7) UK ayBten of datea DAY * MONTH - YEAR UPX/ASl. - LANClOl.ASJ- S,2K ' l2 |3 4 COUNTRY AND 1 NAME OR | DATE OF REFERENCE | INITIALS | BIRTH NO COMPANY USA OL |Earl |Parka 117.10.23 PC 02 |t9.0R.33 RFC 01 | Edwa rd 125.05.15 RFC J Dinwiddle | 04 115*01.24 RFC t1 05 125.01.12 RFC [ 1 06 ir*t I23.II.2S RFC 1AuatIn |Jonee? 0? on E > (Charles |T Suart 1 1 101.05.22 ucc I06.0S.20 (food year 11 1s16 1 7 1t \1 1 | FIRST VC DATE OF 1 \ FACTORY | EXPOSURE DIAGNOSIS 11 1 1 f 1 |Loula1 vi He 1 1 1 1 t 1 1 1 | 09.I2.4S 1 03.03.73 1 1 t 1 1 1 1 1 1 1 1 1 1 1 1 |Loula- | vllle 1 1 \ 15.11.55 1 00.05.70 1 1 t 11 1 11 1 1 I Louie- I vllle 1 1 1 2S.tl.45 1 19.12.11 1 1 1 t 1 1 |LouieI vllle t t 1 I 06.07.52 1 19.OS.67 1 1 1 1 1 1 1 \ (Louie- I vllle 1 t 1 19.06.14 1 09.04.64 1 t 1 1 1 1 1 |Louie- 1 vllle 1 1 1 1 | 17.01.62 1 00.02.74 1 1 t 1 1 1 1 t 1 1 t1 1 11 1 1 |S Oierle- 1 | eton 27.OB.44 1 1 1 00.00.6S 1 1 1 1 1 1 1 |H1*R*i 1 1 1 1 ! 1 07.10.46 1 00.08.61 1 t 1 1 1 1 1 1 a ACE AT DIAGNOSIS 49 1 1 t 1 1 1 ]i 1 1 p 1 1 1 58 1 1 1 t t 43 1 1 1 52 t t 1 45 1 1 1 1 1 45 1 1 1 41 1 1 9 YEARS OF EXPOSURE TO DIAGNOSIS 24 14 2B 15 20 12 24 15 O o O' v\ ro 1 10 1 II 1 1 L2 11 11 YEARS OF | DATE OF | HISTOLOGICAL EXPOSURE | DEATH | CONFIRMATION 1 1J 11 11 11 11 2t (03.03.73 | 11 11 11 11 11 Yee 1 1 1 1 11 11 13 127.09.71 1 KNIOSM 1 Yee Mr 1 (2S.09.7LH 11 11 28 119.12.11 1 11 1 11 1t IS I07.0I.6S | 11 Yee Yee 1 1 1 1 1 11 11 20 (09.04.64 | 11 Yee t 1 1 1 1I 11 12 124.07.15 1 11 11 11 11 11 Yee 1 1 1 t 1 1 1 11 11 17 123.01.68 | t1 11 11 15 129.08.61 | 11 Yee Yee 1 1 p 1 1 1 1 11 11 J__________L 1 1 n ESTIMATED EXPOSURE LEVEL 1l 1 14 1 15 1 16 1 1 1f | OCCUPATION j OTHER CAREER | OTHhK | COMMENTS 1 | HIGHLIGHTS \i 1 1 1 1 1 Pot Cleaner (Hlatory given |In Annela NY |ACAD SCIENCES 1 (Rolling Stems | Art IRef L NY Acad |(Block Java IVol 329 <l979)|of Sc Synp 1 1914) p S3 (page 190 In 11974 1 IFaper by }Aleo Block 1 |R R Cottine of(Jana 1.7.74 1 (OSHA Ip 51 11 1 fPot Cleaner |Ref 1 |(Cf Slock) |Aleo Block 1 IJAHA 1.7.74 1 Ip 53 11 1 |Pot Cleaner |Loulsvl1le 1 1 IRef 1 MCI Block) (Courier |Aleo Block i (Journal 1 t 102-09-SO 1 1 |Pot Cleaner IRef 1 |<Cf 1 1 I Pot Block) Cleaner ! |Alao Block 1 (Ref 1 |(Cf Block) (Also Block 1 ____ ______ 1 |US Air Force| 1 1 IRef 1 + 1 (Pot Cleaner |Loulevft1e | Tlaiee 21. 7.7 S KCf Block) |Rellred April l 11974 1 (Also Block 11 1 l (Ref j 11 11 1 1 1 (Ref | 1 1 1 r P** 11S. A Sheet 2 '''^jslana ICl CH KM I CALS 4 POLYMERS CROUP LIVER Angiosarcoma Cases - (Review Date: l Jan 190 7) UK eysten of dates DAY - MONTH - YEAR WPX/ASL 2 - LANGMH.ASKS , 10 12 COUNTRY AMI) REFERENCE NO NAME OR INITIALS DATE OF BIRTH Raymond Get tleF1 nger? 08.11.11 RFC FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 1 TEARS OF | DATE OF EXPOSURE \ DEATH I _______ \______ HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION Lou la- 20.03.43 01.01.74 41 29 24 111.01.75 villa 2000 ppm OTHER CAREER HIGHLIGHTS OTHKR COMMENTS I I I |Ref I Las |wrong fIguret. |re first leapoSuTe. |Loutsvl1le I Times 129.10.74 MM. 75. |10.1.76 1 1i t i*i JO 1 |16.08.11 i Goodyear |PP1C>r. 12.06.31 t 00.03.68 | 55 i 17 !1 1i t i 1 1i 1 iii "1 (27.03.09 i Goodyear 1 Niagara 14.10.46 i 00.01.10 I 61 ! 1i J i1i l 1i 11 1i 12 (Francis A 117.11.18 i Firestone |Pottetown! 11.07.44 02.03.69 t 50 i 20 I Hartman i ( P* ii i 1 ii i ii i 1i i ii 1 1i 1 \t i i i it iii 11 i i 11 _j _j -L 1 %1 1) IRichard (01.12.21 | uoc I Edward i 1 |Clendentn i 1 i j *1 IS Charle-I \ .ton p 11 -L 1 11.12.42 | 00.05.74 i i i L i i i i _j.-- i 52 i 12 i i _j jJ 1L t j___ i 11 t U (10.05.66 | Yes 1 11 1 ii 1 21 116.01.70 1 Yes 1 11 1 11 1 19 102.05.69 1 Tea i ii i ii i ii i ii i ii 1 11 1 11 j _1L_ 1 ii f 26 107.04.74 | Tea 1 11 1 11 _J1 n 3: > o o 0* 11 11 1 I 1 (Ref 1 11 1 1 i1 i1 1 1 1 J Ref l i1 1 1 i1 IHtgh IQ yra|IO yra aa 1 (Utility 6 1 |Ref 1 4 letter 1 Irasctor op. (Service op. |of 26 April 1 |<oot cleaner|Bagger 1 1976 f roa P |* separate (Dryer op. JRussel 1 A Park P |(crew cleaned|Strlpplng op. to J T Seawe11 t ^autoclaves) (1 yrs prior (of MCA 1( (service In 1 I| (tyre plant 1 1 12000 ppm i p i 1 1 i i i 1 1 1 1 1 1 (Char lesion (Dstly Hal 1 (21.7.75 i _i 1 1 (Never dlag- |nosed as eng- 11 osarcoma of f t Iver. I nl mi n- )at Ion g( veil I ii (letter 7? Mdy 11984 from |J A Sain. J__________________ | Amount hi IASI - Nn | den< i* nl |ex|Mismv. I_________ __ Pane 26 IPSA Sheet 1 COUNTRY AND REFERENCE NO NAME OR fNITIALS DATE OF BIRTH <A "!' ^7- %/>,, r 6 [Cl CHEMI CALS A POLYMERS GROUP LIVER Angloaarcona Cases - {Review Date: ] Jan 190 7) UK Systen of dates DAY - MONTH - YEAR UPX/ASl 2 - LANhlOCASk-5 FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO D1ACNOS IS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL COMF1RHATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS imif x I OHM! NTS | Janea |Havard |0*.II.27 RFC i | LouieIvtlU | 06.05.50 | 00.00.69 i i 41 i [9 11 ii ii i i i i ii [i ii i i i ii i i i |Peerenboon[06.05.31 RFC i |Lout*- (villa t |i i 23.06.55 II.10.74 i i 1 43 i i i 19 ii i ii i i i ii 1t ii ii i |Charile |Arthur ! I 122.04.26 ) RFC ii t i t 11 ii [Avon Label 15.09.54 00.00.75 *6 i 21 ii i 1 I ii i i i ii i 1 i ii ii ii i i i ii ti IVlirgU 100.00.15 tree |Christ Ian I ii ti 11 i 1 |S Charle~| 00.00.43 i 19.06.75 1 60 32 1 aton | ii I ii i 1 I ii i I ii i ii i i i ii i i ii 1i 131.08.17 Goodyear 1 Niagara | 00.00.55 30.01.76 1 56 i 21 ; [Cheater (Hinkle I 107.09.09 I UCC 11 i 1 t1 i | I1 Ii |S Charle-| 00.12.46 Early 77 I 67 i 30 t aton [ i 1 i it 1 t1 1 ii [ ii __ [ 0* 127.03.69 11 i[ 1 1i it 11 [1 Yea 1 1 [ [ 1 1 1 | 1951-4 VCH |polyaer|laatlon |Froa 1954 |Table 4 In lonwarda in |Wagoner | Amy and other [Teetleony t [service. | 11S Sena t e 146-50 Amy |Conf1 tied 1 n 1 |M N Johnson 1 |ltr 07.OR.70 [1 1 ti Yea 1 i 19 |16.10.80 on 11.10.74 1 i i \ 1 i 1 i but ao 1 1 1 1 i poat-norten i ii 16.10.60 i [ 1 i ii 1 1 i ii i i i1 i 13 |02.11.75 i [i i ii i[ i[ Yea i M3 yr. INavy (autocleanerl |0 yra on |Eatol [Tyre Store IplaatJclaer| 1 1 1 1 [ i 1i [ ii |6 Carboaet [operation 1 1 |Dr M N Johnson lletter of 124.2.01 nm| f 1 med death |6 years alter IdlagnusIs [Conf 1 need 1 ii [H N Johnson |lt r 07.08.tH |Alan Rolling |Stone sag. 115.01.76 | ii 1 1i 1 32 106.04.76 i 1 ii 1 ii i 1i i ii 1i Yea i \ 12000 ppM 1 1 1 1 i i 1 1 1 1 1 1 1 1 | W1 1 II aa!i|Mii 1 | Son Caret 1 e |2I lime 1915 (Char teat on (Dally Ma11 121.7.75 |i i1 i 16 [30.01.76 1[ |i \\ 1 22 102.01.77 1 1i 11 11 11 Yea Yea i 1 [ 1 r i i i i i i i i 1 [ [ [ 1 1 1 1 1 1 1 | NIOSIt l et r ei |of 25.10.79 | 28 yr s ut < 1. pllCi nr M |XetI red | News i el e.i-.i 123.2,7/ 1 _J i J______________ T S 9 0 0 vw o* ^4 Page 27 1>S A Sheet 4 *i ' -J, C'n!r ':3? * "^> 3 ** l Cl CHEMICALS k POLYHHtS CROUP LIVER Angiosarcoma Cases - (Review Date: I Jan |98J) UK ayateB of dates DAY - MONTH - YEAR WPX/ASI. I - LANhlOCAM-S. I t i2 i3 COUNTRY AND | NAME OR | DATE OF REFERENCE 1 INITIALS ( RtRTK NO j USA 4 COMPANY l |3 1 1 1 | FACTORY 1 1 i 6 FIRST VC EXPOSURE 7| S1 9 DATE Of | ACE AT 1 YEARS of DIAGNOSIS | DIAGNOSIS | EXPOSURE TO DIAGNOSIS i 22 21 24 n 3: > o o h* c.n j |Charlea f Edwa rd |Hoore (02.10.23 RFC (Loutsidii. 11.07.47 00.01.76 | 32 I 29 i i i i i P 1 i 1 i 1 1 P P ( 1 1 i 100.00.23 I17.0S.I7 Cr*.t Aa*r1can Qicalcil Coapanv uic i | FI tehburg IMaas. i M.09.SS |S (fettleI atoo T555 0A.04.7S | 77.oi.tT 1 30 SO I 1 13 is i i i i i i i i 1 1 i i 1 t i 1 r i i | Removal from register ronf need In R Kaminski letter of 3 November 1980 i i l to 1 u 1 1 YEARS OF | DATE OF EXPOSURE 1 DEATH P P f ( 28 104.12.76 t 1 1 1 I r i \ i i i i i t \ i i i i 14 I0A.O4.7S 1 1 747 (KIOSH eaya 26) 177.05.77 1 1 1 1 1 P 1 P ( 1 1 1 1 P 1 1 1 1 1 1 P 1 1 12 HISTOLOGICAL CONFIRMATION Yea Yea Ctiolsnglosarcoma (R Kaminahl 76/7/79) 13 | 14 1 13 ( 16 ESTIMATED | EXPOSURE | OCCUPATION | LEVEL | 1 OTHER CAREER HIGHLIGHTS | | t OTHER GUHMt-NEb ii (Ixtul svl l le |Timea 26.1.76 (aald he wax (the IIHli AS |victIm at IBelts 1 ane ot |whom 8 had Idled by (26.1.76 (In hie let ter (or 16.09.81 | Dr H N Johnson Iconfirms (hi a | 1 a the (case described (by Darui<ther (Tamburro 6 Yam (In Feb 1980 (Am J Ned 1c1 nr |Vo 1 70 p2WJ Hcdlim to high for 74 yr i |1941-65 non- 11937-39 was |N M Wheeler Isolvent (off and on (vinyl realn |1abourer (unit and 11939-41 may pdlaperaion (have been (vinyl realna Jespoaed aa (letter of 118.8.77 to (J Stafford |gives deta1 Is jRose Kaminski (unit flrat |reactor (aa fitter |c leaner (helper, then (1941 became lahlft (shift fitter (utility man | 1946 became |shift utility (man 11et ter nf I7A/2/79 |R Kaminski l<5 Nov I9KII) | suggest s i l+rt r (NIOSII w11l | ret a I ii on 126.04.63 | f eg litter hlme (employment was (this nenp1 a xm (term!nated (may be .is sin 1 - |at ed with AM. 1R N Whee1cr (letter of 120/2/79 an.1 |Ruse Knntnskt | 1 et t et s ol 126/2/19 .sn.l 15/ | WHO f- r" Jj rmur 28 MSA Sheet S 1l/`'Ulrj ' \d3? in CHE HICAI '1 A POLYMERS GROUP LIVER Angloaarroaa Cases - (Revtew Date: I Jan 1967) UK ays tea of dates OAY - MONTH - YEAR UPK/ASL 1 - lanuocasi-s. 'i COUNTRY AND | REFERENCE 1 NO USA j 1 21 1 NAME OR | INITIALS | j 1 1 DATE OF BIRTH 4 COMPANY 11 1 51 6 1 1 7 11 1 1 1 FIRST VC DATE OF | FACTORY | EXPOSURE DIAGNOSIS 11 11 1 1 26 27 78 29 10 31 0 C C't H 0 |John Berry|07.07.23 PC |Louis- | 03.10,*7 00.00.77 1 IvllU | (up to 2 1 11 1 yeara 1 1J 1 after 1 11 1 death) 1 11 1 1 11 1 \ 11 1 t 11 1 \ 11 1 r 11 1 1 11 1 1 11 1 11 1 (J L |Forrest 1 III.OS.16 1 UCC 1 fS Char1e~| 01.0M1 1 30.I1.7 f aton | 1 1 11 l t1 \ 11 1 1 11 1 11 1 j1 1t 1 111.04.17 ucc |S Charle-I OO.OB.44 1 03.11.78 \ | a ton | 1 11 M2.10.07 UCC 1 11 t |S Charie-I OO.OS.42 1 00.03.80 I aton 1 1 1 11 | UVN t1 III.07.II Tenneco 11 1 | FI eaingtoa 11.06.64 1 30.11.ao 1 Chealcali 1 1 1 1 t1 1 t1 t t 11 1 t t1 t t1 1 t 11 11 t |08.M.2) UCC |S Chsr)e-| 12.OS.46 oi.oa.ai t 1 aton \ 1 11 1 11 1 11 1 1l 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 1f 1 11 ________ \ \1 a 9 \ 10 1 1 1 12 1 n 1 14 1 L5 1 16 ACE AT DIAGNOSIS 1 11 YEARS OF \ TEARS OF | DATE OF \ HISTOLOGICAL | ESTIMATED | EXPOSURE TO | EXPOSURE | DEATH | CONFIRMATION | EXPOSURE | OCCUPATION 1 OTHFR CAKEKK | OTHER | COMMENT DIAGNOSIS 1 1 | LEVEL | HIGHLIGHTS 1 1 11 S2 (death) t Cl 61 71 58 57 2a (death) 37 34 30 17 3S \1 \ LB |11.02.73 | 11 11 11 11 11 11 11 11 11 11 11 11 11 11 I 20 111.11.78 1 1CH105H 1 l*.T* 17 land C |Dally Mall 1 1 1 hi) 1 11 1 1. 1 1 33 103.II.78 1 11 11 t 16 101.03.80 | (1 t1 11 1 IS 130.12.80 ( 11 11 (1 11 11 11 11 \ n 107.04.82 1 \1 11 \( 11 11 \1 1r 11 1r 1r 11 11 11 11 j1 Yea Yea Yea Yea Yaa Yea r | Exposed In |Various (obs | R KaaJ iihk i | tone degree 1 In PVC (letter nt rto 22 |pianta froa Ichealcala (cold rooa to| 126/2/79 and (Prof. Taahoran phut aaln Ipaate (letter of fenpoaure (recovery to I1/J/7Y |vaa to VCM, |PVC charging I probably (operator to Ihlgh Ipaate 1 Icha rglng. 1 1111 August 1 |1965. 1 ITeralnated 1 (eaployaent 1 IJan 1966 1 High |Operator to (Eapoeure In |R N Wheeler 1 |10.10.76 |bulk and (Itr of 4 .Ian 1 Idlepereion PVC |1979 and 1 lasnufacture (Char 1estnn 1 (Dally Hall 1 (10.11.78 and 1 (R Kaalnakt 1| 1 1 126/2/79 |R KaalnsV! 1 1| 1 1 1 1| (6 - Unknown 1 Maintenance Iletter nf 16/4/71 (R Kanlnshl ILettera ol M 9th June I9BO |t 3th Nov I960 |9 - Hlnlnal IHechaalc 1 |6 yrs 1 |Elsewhere 1 III yr. 1 (Boiler houee| 1 |Operator |9 yrs (High (But | Cheatcal | Froai 1959 to |Dr Darey (not aa high [Operator In 11976 AllphatIr Iletter |aa reactor {charge |Cheat rale | 16. 10.8 1 .a ml (cleaner |reactor (operator and 1 R H Ultra-1* l |would |f run July 197b |]et t er id |eKper1pnce) 11 0 date (9.1 1.81. |Worked aa | Foreaan |AJsc |]r [>,i . y |tabourer |A1tphatir |1et t er nt f f rrw |Cheat cal |0? .O 1.81 1. IJtine 1941 |OperatInn |ctat r -0 .li .li 6. 110 Ha y 19461 land nay |lia vc 1 |11eaued 1 re.tcf ora 1- 11 licit t lae J-------------- r> Pg* 29 USA Sheet 6 0 ' 9j> > 0 ** J' t't Cl CHEMICALS 4 POLYMERS GROUP D LIVER Angiosarcoma Cases - (Review Date: k Jan 1967) UK system of dates DAY - MONTH - YF.AR WPX/ASi, 2 - LAN(,10( ASh'i , > 1 2 1 1 1 4 f5I 6 7 COUNTRY AND | NAME Oft | DATE OF REFERENCE 1 INITIALS 1 BIRTH | NO COMPANY US 12 11 |C V Clrouxl22-02-00 | Monsanto FIRST VC | FACTORY 1 EXPOSURE 11 Springfield 15-10-51 1 Naas | DATE OF DIAGNOSIS t 00-07-79 i t i i i t i i i i p \i i US 11 US 14 US 15 US 16 jt |S Ferguson 108-10-27 1 RFC J Jnr | (Louisville 09-09-54 II-05-82 ii i i i t i i i i i 1 Nr Bjrria t i 1 29-01-14 | RFC I Louisville 1955 03-11-82 t 109-01-12 t ucc )i i |S Charl-| 21-07-44 Iston ( 18-07-63 1 127-08-12 | The General lAshteb (Tire and (Ula (Rubber Co X | 1l-06-56 121-08-81 | i i i i i i t i i 1 i f 1 1 1 1 1 J i i i i 8i i ACE AT DIAGNOSIS 71 i i i i t i i i i t i i i i t i 54 i i i i i i i 48 i i i i i i i 71 i i 1 i 1 50 1 1 1 1 1 1 9 YEARS OF EXPOSURE TO DIAGNOSIS 28 28 27 39 27 1 10 1 1 I 1 YEARS OF | DATE OF EXPOSURE | DEATH 1 i1 1 14 117-05-80 |(ln PVC p 1 autoclave i Urea) i i i i 1 1 1 J i i 1 1 1 i i |i 1 28 (Alive 1 t i i |i 1 10 (04.06.81 i t i i i i ( 14 |18-07-6) i i i i 1 27 |Alive i i i i 1 1 J 1 i 1 11 12 t t1 1 14 | ( 15 1 I*1 11 1 1( HISTOLOGICAL | ESTIMATED I I CONFIRMATION | EXPOSURE | OCCUPATION f OTHER CAREER 1 1 | OTIlHt ( cnHMtNrs 1 LEVEL | 1 HIGHLIGHTS 1 An autopsy uaa done and laaedlate 1f 1 11 (The death |1940-1951 1 | (certificate!Various Juba] (gave |in polymer | 1 ( (T nfornar1 mi Iglven In (letter nt eauae of |Mr Giroux* (manufacture | death given |usual |BUTVAR | (February I4IW (from Dr as (occupation |LUSTREX ~Ang loaarcoma* | sa "kettle!1951-1964 | ( |Walter C (Barnes n( (operator" (Various Johs| (In (In and | (Honaant o | SprlngH eJd to ("chemicals (around PVC j |Dr A Muon ot JIndustry", (autoclaves | |Hnrmant o | (1964-1971 ( |Europe. Yea | f | | 1 | | 1 | I | |Various ( Iclerlcsl | |Jobs In PVC ( (polymerisation tf.cilitr/ i (Retired | 101-01-71. I 1 (Multiple 1 | (Job. | (Including ( 1 1 ( 1 1 1 i 1 (Prof Tsmbuno (letter of (12 Aug l9R2 * I ifoir i (Dr M N Jolmf.un | (Operator f (letter of | |Folycleaner.| (28 Feb 198k. 1 ii i J (Tea 1 PPoly | 1965 left RFC (Dr H N lohnaoii | (Operator + | to become a (letter of | (Autoclave (Clergyman. |1 Nov 1982. | (Cleaner f (28 Feb 198k 1 IH5WS. | 11 1 (and 9 Aug 11984. 11 tt Yes (High from ( 1 1 f 1 1 |1)r Darey (1944 to | | | 1 et t er o! 11955. ( | Ned 1 \m froal | | (1955-1958 | ( 11 1 Yea (Moderate 11956-56 | | |labourer | | (1956-57 | I (prod helper j (5 Sept (981. 1 1 ( (ft W Laimdr t. (letter of ( 12 Sept |9H 1: | apnt ted ai 1 (1957-70 | (meill i a 1 | (operator ( (Hay I9H1. 1 (1970-75 | I Je lerlrlcIan | 1 |1975-piesent| 1 (operator | | Test 1 rig ImiMmii oil ftLty mi ! J!L J---------- ------ T 9 0 0 VW3 JO USA S4a*v C 7 ICl CHEMICALS 4 POLYMERS CROUP LEVER Angiosarcoma Cases - (Review Date: I January 190 7) UP*/ ASL2 I.ANC IOCASI s , l)K system ot dales DAY - MONTH - YEAR 11 11 t 12 1 3| 4 1 5 16 | 7 1 8 19 1 10 1 It 111 ( n I 14 J 15 1 16 J1 1 COUNTRY AND ( NAME OR | DATE 0F| REFERENCE 1 INITIALS! BIRTH ( NO 1 11 1 (TEARS OF |FIRST VC |DATE OF fACE AT |EXPOSURE COMPANY | FACTORY | EXPOSURE ISIACNOSISiDIAGNOSlSITO 1 (! 1 IHISTO- 11 YEARS OF| DATE OF I LOGICAL (ESTIMATED! (OTHER EXPOSURE! DEATH |CONFIRM-1EXPOSURE (OCCUPATION |CAREER ( ) 1 | i (DIAGNOSIS! i (ATION (LEVEL ( IHICHL1CHTSI OTHER COMMENTS USA 37 J___________ _____________ i _JL i 11 JMr J ii 129-08.29| BFC ti | Louis- i mi IOt.OS.84 1 5* 1 31 1! 22 106.08.84 ( Tea 1 High |Worked | f (Payton 1 |vllle 1 1i 1 Iregularly | 1 | |Information given In letter 09.08.04 (from Dr M N Johnson 1 11 1 (In PVC areal 1 1 1i ( (In the | i 1 ti i (early days f p 1 1i i (was a | i 1 1i i Ireactor 1 1 ii 1 1i t1 i t (cleaner 11953-76. I i I IS 1JUB 1 ti 128.04.22|Air i p11 1p (Calvert 100*02.63 119.01.84 1 6) ] 20 ii J 1i 10 (28.10.83 \ Tea 1 High |Hornet 1 i t 1 (Thrombo cytopenla and leukopenia since (since 1978. Cold treatment for arthritis 1 (Product a ICity ii i (1963-1982!progression! 11976. Under Dr's care about 6 months it (i t (Iron helper! (before death, had passed standard physical ii i i (to senior | (examination 3 months earlier. J Barr 1 ii i |operator, | (letters of 22.10.84 and 23.01.85. ii 1i i |cleaned ( 1 ii i< [p i1 i t |reactors, J 1 .tripping | i i 1 ii i (end | \ ii ii i |recovery 1 i ii it i Iareas aa 1 i ii ii * locll 1 1 ii ii i (charging 1 1 t1 ii i (operator. I t j 11 ip i ii i i\ ii it 39 (J Menice (27.06.1 SIPsntaaote IPasaalc 1 I960 I March t 65 1 24 i 1i 23 129.06.84 | Yes J Low 129.09.60 - (Worked |Never In hospital for any chronlr or lacute medical problems. Death certificate ii |iM4 i i i (May 66 |Before (states causa of death cardio-pulmonary ii ii i (Vleyt (I960 lerreat secondary to angiosarcoma of ti ii i |Fabrication!with US |liver. ii it i | Plant |Ur ILetter of (5.07.86 free John E Ertel ii ti t 1 High (May 66 - | Force* (of Penteaiote with letter of 24.02.06 ri ii 1 1 hug TO |United (from Dr Auerbach, Pathologist. ii ii i (Utility (Wool i ii ii i |Resin (Dyers i ir ii rr i J pi i (Operator (end |(lac Jul 66(0fcenite 1 I ii O 3! ii > ii ii 1i i |- Sep 6T | 1 ii i (Reactor | 1 1( 1 (Operator) 1 1 11 i 1 Low |Sep TO-82 | 1 o ii o ii ii 1( 1 (Hononer | 1 1i i (Operator | i 1i 1 | Low |1982-81 I 1 ii ii CO i ij i 1( I( 1( 11 1i ( 1 1 1 1 (Mill | (Operator, | (Calendar | (Shop, licit 111 | retirement | I 1 ( 1 1 ji Ji 1 t1 r r( r fr* M YUGOSLAV IA j. j*n 3,J? ICI CHEMICALS & POLYMERS CROUP LIVER AngloaarcoM Cases - (Review Date; I Jan 1907) UPX/ASL - 1 AHt.JOt ases, )> COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF IIRTH COMPANY YUGOSLAVIA 01 05.04.14 JllftO Vint I Split 10 12 n rim vci date or ACE AT YEARS Or EXPOSURE YEARS OP EXfOSUIS | DIAGNOSIS DIAGNOSIS TO EXPOSURE I DIAGNOSIS ___________1_________ DATE OP DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS 00.00.51l0a.04.73 I * 59 20 0S.O4.7J SARIC t l paper Env Health Perspective Vol |7. PP 189-192 1976 5.11.11 Jugo Vlntl Spilt 00.00.50112.07.73 1 I I -t 42 23 ia 12.07.7J Yea* VCM Production *1n hla letter of 1 Oct 1978. Dr Splrtas of N10SH changed the etatue of Case 02 to VLH production employee. Dr Splrtaa also notified a new Ceae 03 also a VCM produ< t ton worker. 04 11.06.JO Jugo Split 15.l2.58f0J.09.78 20 18 03.09.78 Vlnll oae Realnek1 letter of 19 June I960 IARC letter of I April 1962 } f f I I I I f I I 1 f I o1 3: >I o oI O' u 1 o Page 32 Incidence of ASL Cases Per Annum TABLE 1 (Review Date - 1 Jan 1987) By date of death 1955 ........................................................................................ 1 60 7 .............................. 1 8 ........................................................................... 0 90 1960 ........................................................................................ 0 1 ........................................................................................ 1 21 3 ........................................................................................ 0 4 ........................................................................................ 2 5 ........................................................................................ 0 6 ........................................................................................... 0 7 ........................................................................................ 1 8 ........................................................................................ 5 9 ........................................................................................ 3 1970 ........................................................................................ 2 1 ..................................................................................... 3 2 ........................................................................................ 5 3 ........................................................................................ 8 4 ........................................................................................ 5 5 ......................................................................................... 11 6 ....................................................................................11 7 ........................................................................................ 9 8 ....................................................................................10 9........................................................................................... 5 1980 ......................................................................................... 10 1 ........................................................................................ 5 2 ........................................................................................ 2 3 ......................................................................................... 10 4 ........................................................................................ 7 5 ........................................................................................ 5 6 ...................................................................................... ^_2 Total 125 CMA 0 0 6 5 2 0 N.B. 1 Does not Include Italian 01 but does include German 03. 2 Hie 1977 total includes US case 24 which is a Cholangiosarcoma. 3 The total does not include US 33 and 36, F 15 and G31 and 32 who are alive. WPX/ASL2 - LANGI0CASES.8 Page 33 Distribution of ASL Cases by Country TABLE 2 (Review Date - 1 Jan 1987) USA W Germany France UK Canada Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway Total 36 *** 3] ** *** 21 *** 12 10 3 **** 4 ***** 4* 2 2 2 1 130 % <?, ^ `c Oy ''r - `r \;:a A . v\ 'v \ > 'V., v: ' -SA ' , `f : A ' Vx \v :0 Vx T Z S 9 0 0 VW3 * Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholangiosarcoma; & US 33 and 36, F 15 and G 31 and 32, who are alive. **** Includes one monomer worker. ***** Includes two monomer workers. i.e Western Europe North America Rest of World 76 46 8 WPX/ASL2 - LANG10CASES.9 Total 130 Page 34 Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1987) (a) V) Europe Of the 76 cases In W Europe, 65 have occurred in clusters at 11 factories. Of the 31 German cases, 28 have occurred In clusters at 4 factories. ASL Cases Dynamit, Trolsdorf, Germany BP, Barry, UK Hacker, Burghausen, Germany Chloe Chimie (Formerly RP), St Fons, France PCUK, Brlgnoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Germany ICI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium 12 9 9 8 7 5 4 3 3 3 _2 65 'a d? V^r % S V * 9O tv\a \ . .. V n NB: There are 32 pre 1962 PVC plants In W Europe; 18 of these have had ASL cases (Ref Table 8) v- \ (b) N America Of the 46 cases in N America, 38 have occurred at four factories out of a total of 54 factories:- In N America 42 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawlnlgan, Canada UCC, S Charleston Goodyear, Niagara 14 10 10 4 \ --a xr* o c* _ <y i 'o rl r" 9. \ 71 Jr" v5 r. j-n vS 9 0 0 VW3 38 NB: There are 28 pre 1962 PVC plants in N America; 12 of these have had ASL cases (Ref Tables 9 & 10) M fO (c) Rest of World to The 8 ASL cases are believed to be in 1 cluster of 4 and 2 clusters of 2 cases. HPX/ASL2 - LANGIOCASES,10 Page 35 TABLE 4A (Review Date - 1 Jan 1987) Latency Periods (Years from first Exposure to Diagnosis) Count ry No of Cases W Europe Belgium 2 France 21 Germany 31 Total Years 35 545 632 \ Average V" 17.5 ^ - o- v"" 25.95 * V' 20.38 * , Italy Norway 4 74 18.5 *> ` Kn % 1 22 22 4> O N America Sweden UK 5 122 24.5 12 272 22.66 * 76 1702 22.39 W Europe Average Rest of World US Canada 36 910 25.27 * 10 204 20.4 it 46 1114 24.21 N America Average Czechoslovakia 2 30 15.0 Japan 2 39 19.5 Summa ry Yugoslavia 4 8 85 21.2 154 19.2 Rest of World Average CMA 0 0 6 5 2 3 W Europe 76 1702 22.39 N America 46 1114 24.21 Rest of World 8 130 154 2970 19.2 22.84 World Average * Of the countries with > jO cases, France, and USA have an below world average. rage latency period above world average, Germany, UK and Canad WPX/ASL2 - LANGIOCASES.il Page 56 JV.- - (r. . . DISTRIBUTION oF`J'LATfeNCY: PERIODS in f '-4837 TABLE 4B (Review Date - I Jan 1987) 1 1 1 \ 1 1 1 11 11 1 1 1 i 1 1 1 1 1 1 I Average | 1 0-9 yrs | 10-14 yrs | 15-19 yrs | 20-24 yrs | 25-29 yrs 1 30-34 yrs 1 35+ yrs || Total I 1 Latency | i 1 1 1 1 1 1 1 1 1 1 Period | 1 1 1 1 1 1 1 11 11 1 1 1 1 1 1 1 11 1I I Belgium 1 1 1 21 1 1 1 1 1 2 1 t 17.5 1 | Canada 11 1 31 11 1 5| 2 !1 1f 1 1 10 1 1 20.4 | 1 1 1 1 1 1 11 1 1 I Czechoslovakia 1 1| 1| 1 1 1 11 2 11 15.0 1 1111 11 11 1 France 1 1| 4| 31 7 3 3 t 1 21 1 1 25.95 | 1111 11 11 | Germany 1 5| 9I 10* | 5 2 1 f 31 1 1 20.38 1 I Italy 11f1 1 1 2I 2I ! Ef II 4 11 18.5 | | Japan 1111 1 1 1| 1I I1 11 1l 1l \1 11 1 11 2 11 19.5 t 1I 1l iJ 1 1 | Norway 1 1 1 1 1| 1 1 II 1 11 22 1 1] 11 1l 1l 1I 1l 11 11 t Sweden 1 ! 1 21 1 21 11 II 5 11 24.5 | t UK 1 1| 11 1 5f 1 14 21 11 11 1 1 12 1 1 22.66 | I USA 11 1 1 1 1 1 21 7t 9I 8 11 11 5 5 1 1 36 1 1 25.27 I 1 1 1 1 1 1 1 11 11 | Yugoslavia f 1 1 t 41 1 1 11 4 11 21.2 1 11 1 1 1 1 11 11 O t( 1 3: > \ TOTAL l t| 12 1 II 1 o o 0" * Includes G 03 aerosol can filler tn w ji 1 33 1 1 1 35 1 1 1 28 1 1 1 13 1 1 11 11 8 1 1 130 11 1 1 11 22.84 | WPX/ASL2 - LANGIOCASES,12 Page 37 (Review date 1 January 1987) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE | YEAR OF 1 LATENCY PERIOD | ARITHMETIC MEAN ! LATENCY PERIOD | FIRST EXPOSURE 1 (NO OF YEARS) I OF LATENCY PERIODS 1 11 11 47 I 1939 1 38* | 1 46 ! 1940 1 1 244 = 34.86 1 45 | 1 1 37.21,37,41 | "7 1 44 1 2 1 32,38 | 1 43 1 3 1 38,14,32 | 1 1 4 1 28,11,24,20,24,34,39 | 718 m 26.59 1 ! 5 1 27,22,28,29 | 27 1 1 6 1 21,29,31,26,28,15,23,1 1 1 1 30,35 | 1 39 | 7 1 29,24.29,28 I 1 38 1 8 1 28,24,34 | 1 1 9 1 30,26,20 I 521 24.80 1 | 1950 1 26,22,31,19,23,14,33 | 21 1 1 1 1 19,28,17,28,34,29 I 34 1 2 1 21**.15 | 1 1 33 1 3 1 25,22,23,22,20,31,22,1 1 1 1 32*** | 1 1 4 1 21,21,25,25,21,28***,| 1 1 1 22 | 787 9 22.48 1 1 5 1 22,23,24,14,19,21,27 | 35 1 1 1 27*** 24,28,30*** I 1 1 6 1 21,12,27*** | 1 29 | 7 1 19,17.15,13,16,28 | 1 28 1 8 1 18,18,15,17,20 I 1 1 9 1 16,21,25,27 I 490 SS 18.14 1 1 1960 1 13,18,21,25,24 | 27 1 1 1 1 15,16,16,16,19,19,12 | 1 24 1 2 I 13,18.17,12,18,21 I 1 23 1 3 1 16,17,20,21 I 1 1 4 I 16,17 | 180 = 16.36 1 1 5 I 11,19 | 11 1 1 6 I 9,18 | 1 19 1 7 1 16 I 1 18 1 8 1 18 1 9 1 13 |I I 31 = 15.5 1 1 1970 1 I2 1 VIOLA | 11 11 14 1 2 11 13 1 3 1 I 1 MALTONI 14 | TOTAL 1 1 130 CASES 1 1 GOODRICH I 2971 a 22.85 1 1I 1 130 1 * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; F15 and G31 and G32 still alive. < - -c c.O" x. ,,'0 , -Cv . .-O ,, rf-'jS ,-v -ss> ",-0; 'V" Vc WPX/ASL2 - LANGIOCASES,13 .W ,,<v vs C,'2,'V CM6 0065: Page 38 (Review date 1 January 1987) TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION ' MAX POSSIBLE 1 YEAR OF 1 LATENCY PERIOD 1 FIRST EXPOSURE 1 LATENCY PERIODS IN WESTERN EUROPE | NORTH AMERICA 11 1 47 1 1939 1 1 38* 46 1 1940 1 I 45 I 1 1 37,41 | 21,37 44 1 21 1 32,38 43 1 3 I 38 | 14,32 1 4 1 28 | 11,24,20,24,34,39 I 5 1 27 | 22,28,29 1 39 1 6 I 21,29,31,33 7 1 29 I 26,28,15,23,30,35 | 24,29,28 38 1 8 1 28,34 | 24 1 9 1 30,26 | 20 1 1950 1 26,22,31 | 19 1 1 I 19,28,34,29, | 17,28 34 1 2 I 21** 1 15 33 1 3 1 25,22,22,32*** | 23,31 1 4 I 21,21,25,25 I 21,28*** 1 5 1 22,23,24,27***24,281 14,19,21,27 1 1 30*** | 1 6 I 21,12 | 27*** 29 1 7 1 19,17,15,13,28 I 28 1 8 1 18,18 | 15 1 9 I 16,21,25,27, | 1 1960 I 13,18,21,25 | 24 1 24 I 1 1 15,16,16,16,19,19 | 12 2 1 13,18.17,18,21 1 12 23 1 3 I 16,17,21 | 20 1 4 1 16 I 17 1 5 ! 11,19 | 1 6 1 9,18 I 19 1 7 1 16 I 18 I 8 1 18 I I 9 1 13 | 1 VIOLA 1970 1 1 1 11 I 1 21 1 1 MALTONI 3 1 1 1 TOTAL CASES 1 76 | 46 * Giolangiosarcoma ** Aerosol can filler *** US33 and 36; F15 and G31 and 32 still alive 1 ROW 1 1 1 1 1 1 1 1 1 1 1 1 1 23,14 1 1 1 22,20 1 22 1 1 1 1 16 1 17,20 1 1 1 1 1 1 1 1 ! 1 1 1 1 1 1 18 WPX/ASL2 - LANGIOCASES,14 S' ;r ~ * a t, r.it. Yc CHA 006526 TABLE 4E Page 39 (Review date 1 January 1987) PLANT 11 | START | LATENCY PERIODS OF ASL CASES 11 1 NO OF | AVERAGE 1 UP I IN SPECIFIC PLANTS | CASES | LATENCY PERIOD | DATE | (10 OR MORE CASES) 11 11 11 LOUISVILLE 11 1 | 1940? | 12,14,15,19,19,20,24,27,28,28,28,29,29 1 1 14 | 23.07 USA 1 1 31 11 11 11 TROISDORF 1 1954 | 12,13,16,16,18,19,19,21,23,25,28,29 1 12 | 19.91 W GERMANY 1 1 11 SHAWINIGAN 11 I 1943 | 11,12,14,21,22,23,24,24,26,28 11 1 10 | 20.5 CANADA |(1941?) | 11 11 S CHARLESTON | 1939? | 24,30,32,32,34,35,37,38,38,39, 1I 1 10 | 33.99 USA 11 11 r > r ' V'-' ,v^ S&3 V WPX/ASL2 - LANGI0CASES.15 CHft 006527 Page 40 (Review date 1 January 1987) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) YEAR OF FIRS! 1 LOUISVILLE| TROISDORF I SHAWINIGAN 1 S CHARLESTON EXPOSURE I USA 1 W GERMANY 1 CANADA 1 USA 1939 1 1 1 1 38 1940 1 1 11 11 1 1 21 1 37 21 1 1 1 32,38 31 1 1 14 I 32 4 1 20 1 1 11,24 I 24,34,39 5 1 28,29,27 1 1 22 1 61 1 1 26,28 1 30,35 7 1 29,28 1 1 24 1 8 I 24 1 11 91 1 11 1950 1 19 1 11 11 I 29 1 1 2 1 15 1 11 3 1 31 1 1 23 1 4 1 28 1 21,25 1 1 5 1 14,19 I 23,28 1 1 61 1 12 1 1 71 1 13 1 1 81 I 11 91 1 11 1960 1 1 11 11 1 16,16,19,19 1 12 1 2 1 12 1 18 1 1 C t-; - -o ^ A' WPX/ASL2 - LANGIOCASES,16 CHA 006528 Page 4l (Review date 1 January 1987) TABLE 4G PLANT BARRY UK | | 1 BURGHAUSEN | W GERMANY 1 ST FONS 1 | FRANCE 1 BRIGNOUD FRANCE 1 | | SUNDSVALL SWEDEN 1 | | NIAGARA USA 1 | | SPLIT 1 | YUGOSLAVIA! 1 MARL | W GERMANY START-UP DATE LATENCY PERIOD OF ASL CASES IN SPECIFIC PLANTS(4-9 CASES) 1948 | 9,17,18,28,31,33,18,19,18 i 1i 1933 1i 1 17,21,22,25,24,13,21,32,30 i Ii 1939 1 1 21,28,29,37,38,27,41,34 i i 1i 1950 1 I 11,16,18,26,30,25,34 i i 1i 1945 1 1 16,19,27,29,31 i i 1i 1947 1 1 15,17,21,23 i i 1i 1950 1 I 20,20,22,23 i i 1i 1948 1 1 15,16,22,21 i i NO OF CASES 91 I I 91 I 1 8I 1 1 7I i 1 51 1 1 41 1 1 41 1 1 41 AVERAGE PERIOD 21.22 years 22.77 31.88 22.85 24.4 19 21.25 18.5 <*oaO* & V>` Vo^ ,r\*V \ - WPX/ASL2 - LANGI0CASES.17 CM6 006529 Page ^2 (Review date 1 January 1987) TABLE 4H LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT _____________ (4-9 CASES) YEAR OF |BARRY |BURGHAUSENI ST FONS| BRIGNOUDI SUNDSVALLI NIAGARA I SPLIT | MARL FIRST EXPOSURE| UK I W GERMANY| FRANCE| FRANCE ! SWEDEN 1 USA 1 YUGO- |W GERMANY 1939 1940 1 | | | 1 1 1 1 1 1 37,41 | 1 1 1 1 I SLAVIAI 1 1 21 1 1 11 31 1 1 38 | 1 1 4I 5| 61 7| 8I 1 1 1 1 1 I 1 1 29 1 1 28,34 | | 1 1 27* 1 31 1 29 1 1 1 1 15,23 1 1 9 1950 11 131,33 1 1 26,30 1 11 1 1 I 23* 1 |28 1 1 34 1 19 1 17 21 1 1 11 31 125,32 | 1 1 | 20 I 22 41 121 | 1 1 | 22* 5| 122,24,30 I 27 | 1 1 21 6I 7| 1 117 1 21 | 1 1 1 1 1 8I 1 1 18 I 1 I 20 91 1 1 16,25 1 1 1960 | 121 | 11 1| 1 1 11 1 15,16 2 | 18 1 1 11 121 3 117 1 I 11 4I 1 1 1 16 1 5 | 19 1 1 11 1 1 6 19,18 I 7| 1 1 1 11 11 8 | 18 1 1 11 9 1970 1 I | | 113 1 1 1 1 1 11 11 11 21 1 1 11 11 1 11 * Monomer worker WPX/ASL2 - LANGIOCASES,18 t CMA 006530 Page j?*ZhJeci Cc'- v. *Z c ' aJ-0Qej ett ft, - t*-. Pa-H* ^ ap*3h iot io: ?7 ^7 nCou 43 TABLE 5 (Review Date - 1 Jan 1987) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 1986 TOTAL 11 | Western Europe ] North America 1I 1 I1 1 |1 1 1 1 I1 t I1 I1 1i 1l 1 15 12 I1 I1 11 12 14 11 11 13 14 i2 16 14 16 13 16 I7 15 13 12 | 16 I5 11 14 1o 11 17 15 13 12 I5 1 12 1 | 73* ** | 44** Rest of World | Annual Total I1 11 11 |1 112 I1 I5 (3 12 13 15 318 -1 5 1 1 11 2 1 11 19 1 1 10 -I 5 - 1 10 -1 5 12 I 10 t7 15 12 8 I 125 | Cumulative j | Total | Key Events 1 }1 12 13 14 16 |7 1 12 1 15 1 17 | 20 I 25 1 33 1 38 1 49 1 60 1 69 1 79 1 84 i 94 t 99 1101 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Viola 1 t | Maltoni | Goodrich 1 1 1 1 1 I 1 1 lilt 1118 1123 1125 1 1 1 1 1 1 1 1 1 * Includes G03 aerosol can filler but omits It 01 bag extruder ** Does not Include US33, and 36, F15, G31 and 32. All still alive. WPX/ASL2 - LANGIOCASES,19 rs?oo Page 44 (Review date 1 January 1987) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) 1 KEY 1 | EVENTS I | WESTERN EUROPE 1 1 NORTH AMERICA i 1 REST OF WORLD 1 11 1 1 1955 1 1 Cl 1 1 0 11 7 I C2 1 18 19 I 1960 11 12 i i ! I US8 1 C3 I 1 1 1 1 13 14 1 I US5 1 1 Cz2 15 11 16 1 7 1 FI 11 !1 |Viola 18 19 1 1970 11 1 |Maltoni 1 |Goodrich 1 2 3 4 15 16 1 G1 I Swl I G2 I N1,Sw2.UKl,It2 I G3** I G4,G5,UK3 I F2,F3,G6,G7,G8,It3 1 Bl,F4,F5,F6,F7,Sw3 I C4,C5,US4,US7,US10 1 US12.US16 I US11 1 C6.US2 I C7 1 C8.US1.US3.US23 1 C9.US13 I US6,US9,US18,US26 | US19,US20,US22, 1 1 1 1 1 1 Yl,Y2,Czl 1 I Japl 1 Jap2,Y3 1 7 1 F8,F9,G10,G11,G12,Sw4 1 8 1 F10,F11,G9,G13,G15 1 C10,US21,US24* I US27.US28 1 I Y4 1 19 1 1980 1 G16,G17 1 1 I FI2,FI 3,UK4,UK5,G18 1 1 I UK6, UK7,G19,Sw5,G20,G21US | US17, US29, US30,US32| 1 1 1 It4,F14,UK8,G22,G23 I 1 1 2 I G26 I US31 1 3 I UK09,It5,F17,B2,G24,G25,G30| US35, US34, US38 1 4 I UK10, F16, F18, G27.G29 I US37.US39 1 1 1 1 5 1 UK11, UK12,F19,F20,G28 1 1 1 6 1 F21.UK13 1 Total 1 73*** I 1 44*** 1 18 1 11 * Cholangiosarcoma ** Aerosol can filler *** Does not include US33 and 36, F15 and G31 and 32. All still alive. WPX/ASL2 - LANGX0CASES.20 0- '-r . -0' v V STS' ,, cu y > V' ,v CMA 006532 Page 45 (Review date 1 January 1987) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) KEY | EVENTS | | WESTERN EUROPE 1 I NORTH AMERICA ! | REST OF WORLD| 1 1 1 1939 1 40 1 1 |Frl1,Frl6 12 1 3 I Frl4 1 4 IUK1 1 5 I Sw2 1 6 1Frl,Fr3,Sw4 1 7 I Sw3 1 8 1Fr9, Frl7 1 9 |Frl2,Fr4 1 50 IFr7,N1,UK8,UK9 11 I I US24* 1 1 1 I C3.US27 1 1 I US13, US29 1 1 C2.US19 ! 1 Cl ,C5,US5,US7,US28,US35 1 1 C4,US3,US9 1 1 C7,C9,US8,US11,US21,US31 1 | C6.US22.US26 1 1 US1 1 I US12 1 I US16 IY2, Cz2 1 1 ISwl,UK5,Fr20,G30 I US10, US32 I 2 |G3** I US4 1 3 IG15,It3,G26,G31*** I CIO, US37 1 4 |G7,G8,UK4,G19 I US18.US33*** 1 5 |G11,G16,G18, Frl5*** 1 US2.US17.US20.US34 1 |G23,G28,G32*** 1 1 6 IFR10.G1 I US36*** 1 7 |Fr8,G4,It2,G2,UK12 1 1 8 I Fr6,B1 1 US23 1 9 IFr2,It4,Frl9,Fr21 1 1 60 |G5,G13,G25,G28 I US39 1 1 1G9,G10,G12,G17,G20,G22| C8 1 2 1G6,UK6,G21,B2,G29 I US6 I 3 IFrl3, UK7,Frl8 1 US38 1 4 I Sw5 I US30 1 5 1Fr5,UK11 1 1 6 1UK3, UK10 1 1 7 1 It5 1 1 8 IUK13 1 Viola 1 | 9 |G24 >0 1 1 1 1 1Japl.Yl I Y3 1 1 1 ICzl IJap2 Y4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 11 1| Maltoni | 2| 3 | 1 || 1 1 1 Total 176 ! I 46 1 18 1 11 * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** US33 and 36, Frl5 and G31 and 32 are still alive. Subject to Ross v. ' 0 . L4tli JuaioiL.i , `.Calcasieu Pari si,, In -0 . ' 0 - CZ57 :.c r Jourt Lcui 0 iana :X& c C-v`> -A&' V0'"' WPX/ASL2 - LANGIOCASES,21 CMA 006533 Page 46 WPX/ASL2 - LANCI0CASE5.22 (Review date 1 Jamary 1987) TABLE 8 WESTERN EUROPE FVC PRODUCERS - START-UP DATES vs ASL CASES (PUTTING G03 & It.Ql) 1 START-OP| COUNTRY NAME | COMPANY NA>E I LOCATION I ASL CASE NLMBER 1 YEAR OF YEAR 1 1931 I West Germany IBASF 1933 I West Germany IWacker 1 ILudwigshafen |Burghausen 1 I 1st Exposure 11 104,07,11,15,23,24| 57,54,55,53,55,69,60,531 1 1938 1 Italy 1939 I France IMontecatini 1 |Acna I Shone Poulenc/ I St Fore 125.31.32 1 103,09,10,11,14 155 1 146,48,56,41,43, 1940 1945 1946 1947 1948 1949 1950 1 lAtochem 1 115.16.17 155.41,48 I United Kineianl ICI I Runcorn 1 1 I Ohited Kingdanl ICI IHillhouse 101,04,12 144,54.57 1 Sweden IKsnanord I SundsvallC Stockvik] 101,02.03.04,05 151,45,47,46,64 I Switzerland llonza/ICI since|Sins 1 1 1 I France 11982 1 IRhone-Poulenc IRousillon I 101 1 146 1Italy I Montedison | Porto Marghera 102 157 | UrLted Kingdanl BP Chan/ICI I Barry 103,05,06,07,08,09166,51,62,63,50,50 1 |since 1982 1 110.11.13 166,65.68 I West Germany ICWVHuls Ibfarl 109.10.26.29 161.61.53.62 1Belgian ISolvay | Jeneppe 101.02 158,62 I France IPCUK/Atochan IBrignoud 102,04,05,06,12,19159,49,65,58,49,59,51 1 |France 1 IRhcne-Faulenc I St Auban 120 107 1 150 1951 1952 1953 1954 |Holland I Shell | Norway I Norsk IItaly I Montedison IItaly 1 Montedison lAisttla IHalvic I France 1Solvay IItaly ISolvay 1 Spain |Rio Rodano | United Kingdanl BIP |West Germany IHoechst |Wast Germany IDynasit IPemis IHeroya |Brindisi |Temi IHallein ITSavaux I Ferrara IHemard. lAycliffe IGendorf ITrcisdorf 11 101 150 11 11 1 108.13.18 103 1 157.63.63 153 11 11 118 i55_____________________ 101,02,08,12,16,17156,57,54,61,55,61, 1955 1956 1958 1960 1 I Spain I Spain 1 I West Germany I Italy 1 I Monsanto IberiaIMonzon ICalqsa ISablnaidgo IHispavic ITbrrelavega ISolvay Iftieinbepg IS C Ravenna IRaveima 119.20.21.22.27.30154.61.62,61,55.51 11 11 11 11 104 159 |West Germany ILonza/Id since|Waldshut 106,13,28 162,60,60 1 11982 1 1 1962 1 Portugal IGLres IOporto 1 1965 1Fiance iBione roulenc IMontlucxon 121 1Italy IPozzi IFerrandina 1 lUaet Germany IWacker I Cologne 1 1966 IWfest Germany IHoechst |Knapsack(Frankfurt) 105* 1967 I France |ATD Chimie IBalan 1 I Spain |Rio Rodano I Miranda de Ebro 1 I Greece lEsso Pappas IDLavata Salonika 1 1968 IBel^lun IBadiphil IAntwerp 1 1969 I United Kingdanl Vinatex IStaveley 1 IItaly IRonianca 1 Cagliari Sardlna 1 1970 I Italy ISIR I Porto Torres Sar 1 I Ia |Id IRmcom 1 1971 1 Italy IS C Ravenna |Ravenna 1 I Spain IHispavic IMartorell 1 I Sweden IKsnanord I Sterungsund 1 I United Kirgdai IBP Chem IBaglan Bay 1 1972 | Finland IPekena ISvartback 1 IHolland IDQi IBeek Limburg 1 1976 |France 1Soc Art D*vinyl IMazingarbe 1 1977 I Spain I Monsanto Iberia I Tarragona 1 * Laboratory worker in Research Department I 1 159 1 1 160 1 1 1 1 1 1 1 1 1 1 1 1 1 CMA 006534 1 11 11 -- *iCa ( T+ J*iq TVr VrVT*rf ncf ryf fHe anf t TABLE 9 Page 47 (Review date 1 January 1987) USA PVC PRODUCERS - START-UP DATES vs ASL CASES * CJ -r* H1 +t> ^ , ^f' Cot r rm C K " .5 ;V"/C= f^ -- r--, f r . - v s .`~j A> 5^ 1 START-UP| COMPANY NAME 1 LOCATION | ASL CASE | YEAR OF | 1 YEAR | 1 1 NUMBER | 1st EXPOSURE | 1 1939? l*UCC 1 S Charleston 107,13,19,21,24,144,42,43,46,39, | 1 1 127.28.29.31,35 141.44.42,46,44 1 1 1940? I *BFG 1 Louisville 101,02,03,04,05,148,55,45,52,44, | 1 1 106,09,16,17,22,162,45,50,55,47, | 1 1 126.33.34,37 147.54.55,53 1 1 1946? |*UCC 1 Texas City (Partially closed 1977)1 | 1 1947 | Goodyear 1 Niagara Falls 108.10,11,20 146,51,46,55 1 1 1948 I Firestone/ 1 Pottstown |12 14 9 | 1 | Occidental ! 11 1 1 | Uniroyal 1 Palnesville | | | 1 1 (closed 1975) | | | 1 1950 I Monsanto 1 Springfield |32 |51 | 1 1 (Closed 1975 1 | | 1 1952 I Dow 1 Midland (No PVC since c 1975) | | 1 I BFG 1 Avon Lake |18 |54 | 1 1953 I BFG 1 Deer Park (Formerly Diamond) | | 1 1954 I General Tire 1 Ashtabula |36 |56 | 1 ! (Closed 1984) | 1 1956 I Air Products ! Pensacola | 1 | Atlantic Refining i Brooklyn(Closed late 1960s) | | | | | | 1 I Borden l Leominster (Closed 1984) | | 1 I Conoco l Hebronvlile (Closed 1975) | | 1 I BFG l Niagara | | | 1 I Great American l Fitchburg |23 158 1 1 I Plastics l (Closed 1983) 1 | | 1 I Hooker l Hicksville ^Closed 1980-81) i | 1 I Pantasote i Passaic(Closed 1984) 39 160 | 1 1957 I Atlantic Tubing i Cranston (Closed 1967) 1 | 1 | Tenneco i Flemington NJ |30 |59 1 1 i (Closed 1985) 1 1 ! 1 1958 I Keysor Century l Saugus, Cal | | | 1 1960 1 BFG i Watson, Cal | | | 1 I Air Products i Calvert City |38 163 1 1 i (closed March 1982 Re-opened October 1983) | I Borden | Illiopolls | | | 1962 I Tenneco/Occidental l Burlington NJ | | | .1 1963 1 1965 I 1- 1 1966 1 Conoco/Vista I Stauffer I Conoco I Ethyl I Georgia Gulf l Aberdeen, Miss 1 | ! Long Beach, Cal (Closed 1982) | ** I Assonet, Mass (Closed by Olin 1975, see below) 1 Baton Rouge (Closed 1984) | i Delaware City (Formerly Diamond) | | | | | | 1 |Gen Tire/Pantasote | Mt Pleasant W Va |(Closed 1982) | 1 I BFG I Henry, 111 | | i I Stauffer i Delaware City (Sold to Formosa 1983) | | 1 1967 I Allied *** i Palnesville, 0 | | | I i (sold to Robintech) | | i | Hooker/Occidental i Burlington NJ | | ' i: 1968 I Firestone l Perryville (Closed 1982) | CMA i 1969 I BFG I Goodyear i | Olin ! Pedrickton NJ | | i Plaquemlne | | ** l Assonet, Mass (Closed 1975) (See above) 1 | 1 (Formerly Conoco) l 11 1 1 1971 I Conoco/Vista l Oklahoma City 1 1 1 WPX/ASL2 - LANGIOCASES.23 Continue d Page 48 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP | I YEAR 1 1 1972 1 I 1973 1 1 1 1 1 1 I 1974 1 1 1 I 1975 1 I 1 1 1979 1 1 1 1983 1 COMPANY NAME I Nat Starch 1 I Borden Robintech *** I | 1 1 1 1 Atlantic Tubing/ | Tallyrand | Shintech I Certain-teed | Georgia Pacific | Tenneco/Occidental | Firestone/ Occidental Formosa I | 1 LOCATION I Meredosia, 111 1 | Springfield 1 Painesville, 0 | (sold to Georgia | Pacific who | converted to polystyrene) I | Cranston RI (Closed Freeport, Tex 1 | Lake Charles | Plaquemlne, La | Pasadena, Tex I Plaquemlne | 1 Point Comfort, Tex| ASL CASE NUMBER 1982) YEAR OF | 1st EXPOSURE | * My databank has no information on UCC before 1946 or BFG before 1950 ** Refers to same plant at Assonet ***Refer to same plant at Painesville. Allied plant never operated again for PVC after it was sold to Robintech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. c> ' - r*"V s? WPX/ASL2 - LANGIOCASES.24 0065^6 Page 49 (Review date 1 January 1987) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP I | YEAR COMPANY NAME 1 LOCATION 1 | ASL CASE I NUMBER I YEAR OF I 1st EXPOSURE 1 1943 | Goodrich 1 1 Shawinigan 11 101,02,03,04,05 |44,43,41,45,44, 1(1941?) 1 106,07,08,09,10 147,46,61,46,53 1 1951 | Monsanto 11 11 1 La Salle (Closed 1975) 1 1 1 1 11 1 1957 | Goodrich 1 1 Welland 1 1 1 1 1 1I 1 1966 | Esso 1 1 Sarnia 1 1 1 1 1 11 11 1 1979 | Diamond Shamrock Alb 1 Fort Saskatchewan 1 1 1 1 11 WPX/ASL2 - LANGI0CASES,25 006537 Page 50 (Review date 1 January 1987) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES |START-UF I COUNTRY NAME | COMPANY NAME | YEAR 1 1 |Pre 1939 |East Germany |State Company 1 1941 |Russia |State Comps 1 1950 1 Yugoslavia IJugo Vinil | 1951 I Czechoslovakia!State Comps 1 1955 I East Germany |State Comps 1 1956 |Rumania 1 State Comps | 1957 I Poland 1 State Comps |Rumania |State Comps 11 1 1958 I Rumania 1 State Comps 1 1959 !Hungary 1 State Comps 1 1961 |Rumania 1 State Comps 1 1963 I Yugoslavia lOhls 1 1965 1 Bulgaria |State Comps 1 1967 |Poland 1 State Comps 1 1969 I Russia I State Comps 1 1970 I Rumania I State Comps I Russia I State Comps 1 1972 I Yugoslavia IVlnilplastika 1 1975 I Czechoslovakia!State Comps IRuBSia I State Comps 1 1976 I Yugoslavia 1 Hip | 1977 I Rumania I State Comps 1 LOCATION 1 ISchopau (Vladimir et al I Split INovaky |Bitterfeldt IIcechlm 108weiclm (Dwory) !Tirnaveni ITurda IRisnov IBerente Borsod IBorzesti 1 Skop.1 e I Varna ITarnow 1 Djerjinsk 1Rimnicu Vllcea 1 Volgograd I Zadar INeratovice IKalush Area IPancevo IRimnicu Vllcea I ASL CASE I NUMBER 1 1 101.02.03.04 101.02 1 1 1 1 J J. 1 _L...... 1 1 1 1 1 1 1 1 1 ! 1 I YEAR OF 1 1st Exposure I 1 153.50.54.48 157,50 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 I 1 1 WPX/ASL2 - LANGI0CASES,26 \C! O CHA 006538 Page 51 (Review date 1 January 1987) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP| YEAR 1 1950 | | COMPANY NAME Chisso Corp Kanegafuchi Kag I Tekkosha 1951 I Mitsui Toatsu 1952 | Mitsubishi Mon 1951 I Sumitomo Kag | Denki Kagaku | Nippon Zeon | Toa Gosei 1955 1956 I Ryo-Nichi | Nippon Zeon I Nisshin Kagaku 1957 | Kureha Kasei I Shinetsu Kag 1960 | Denki Kagaku I Kanegafuchi Kag 1964 I Chisso Corp 1966 | Tokuyama Seksui 1967 | San Arrow Kagak | Sumitomo Kag 1968 | Ryo-Nichi I Shinetsu Kag 1970 | Chisso Corp | Denki Kagaku | Kanegafuchi Kag | Kawasaki Yukl | Mitsui Toatsu I Nissan Kagaku 1971 1973 1974 I Shinetsu Kag 1 Tekkosha 1 Aeahi Glass 1 Toyo Soda 1975 1 | Central Kagaku I Toyo Soda 1977 | Unknown | LOCATION 1 | Minamata | Osaka | Sakata | Nagoya I Yokkaichi | Kikumoto | Shibukawa | Kambara I Tckushlma | Uozu | Takoaka 1 Takeo | Nishlki I Naoetsu | Ohmi I Takasago I Chiba I Tokuyama | Tokuyama | Chiba | Mizushlma I Tokuyama | Mizushlma | Goi (Chiba) | Kashima | Kawasaki | Sakai | Chiba | Kashima I Yokkaichi I Hayatsuki | Sakata I Yokkaishl I Kawasaki | Yokkaichi I Kashima I ASL CASE I NUMBER 1 1 1 01. 02 1 1 1 1 1 1 1 1 1 ! 1 1 1 1 1 1 1 1 1 | 1 1 1 1 1 1 1 I 1 1 1 | YEAR OF I 1st EXPOSURE 1 1 1 1 53. 58 1 1 1 I 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 tjDv/ 4<;t n t A^fJTOCASES.27 Page 52 (Review date 1 January 1987) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS I START-UP| COMPANY NAME I YEAR 1 1 1953 | Monsanto Mexlca 1 1954 1 Policyd 1 1955 | Geon Do Brazil 1 1956 | Elchlor I 1960 I Electrochlor I Viplastlc 1 1961 | Indupa 1 1965 1(SOC Paramanga 1(1967 start up I PET Columbiana 1 1966 I Carburo De Col 1 1967 | PIasticos Omega 1 1968 | Primex I 1970 I Policasa I petro Dow 1 1971 I Polimeros Mex I 1975 I Rico Chemicals 1 1976 1 Petroplas 1 1977 I Indust Reslstoc I 1978 | Huls Brasil | Polychem I Policyd 1 1979 I PET Camacari I LOCATION | 1 | Lecherla (Mexico) 1 Mexico City (Mexico) | Sao Paulo (Brazil) I | | | | Sao Caetano (Brazil) | iCapitan Bermudez(Argentlna)I I Mendoz (Argentina) | | Clnco Saltos (Argentina) | | Paramonga (Peru) | ) I Cartagena (Colombia) | Medellin (Colombia) | Mexico I Puebla (Mexico) 1 I | | | | Managua (Nicaragua) | | Conception (Chile) I I St Martin Puebla (Mexico) | | Guyanilla (Puerto Rico) 1 EL Tablazo (Venezuela) I Tlazcala (Mexico) I 1 1 | Cubato (Brazil) | El Salvador | | | Coatzacoalcos (Mexico) I Camacari Bahia (Brazil) | 1 ASL CASE NUMBER I YEAR OF I 1st EXPOSURE 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES(28 CMA 006540 Page 53 (Review date 1 January 1987) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP | COMPANY NAME YEAR | 1 Mid 1950s | ICI Australia 1 1960s | B F Goodrich i Late 1970s| ICI Australia 1 1 I LOCATION | | Botany, Sydney | | Melbourne | | Laverton | Melbourne | | ASL CASE NUMBER 1 YEAR OF ! 1st EXPOSURE 1 1 1 1 1 1 1 _L WPX/ASL2 - LANGIOCASES.29 006541 Page 54 (Review date 1 January 1987) TABLE 15 MIDDLE EASTERN PVC. PRODUCERS START-UP DATES START-UP DATE Sept 1986 COUNTRY NAME Saudi Arabia COMPANY NAME I LOCATION ____________________ 1 I National Plastic |Arabian Petrochemical Company Company |Madiant (Ibn Hayan) | Al-Jubail |Al-Sinahyah I WPX/ASL2 - LANGI0CASES.30 CMA 006542 Count ry: ICl CHEKICALS 4 POLYMERS GROUP LIVER ta|lorcoM Cates - (Review Date: 1 Jan 19..) WPX/ASL - LAMGlOCAStS, I