Document rBkQy4GRBKJOp0EpEJkkabVoE

-1 ; EXPOSURE CONCENTRATION PPM 10,000 t 25,600 6,000 15,360 2,500 500 6,400 1,280 250 640 50 128 5 12.8 3 1 2.56 4 hr Rat 5,521 5,403 5,030 3,413 2,435 739 84 51 17 A/O /?/"" ,) f? VC METABOLIZED 8 hr Man 1,620 1,586 1,477 1,002 715 217 24.6 24 hr Man 4,860 4,758 4,431 3,006 2,145 651 73.8 4.97 14.9 T00S66TZ '^, 4/,c<>'?7 BFG17452 jC/k ri -- /?yf ^ t 1. Minute Volume rat (300 g) = 300 ml/min V, V-t ^ / ^/ . Rat gavage dose^ in Ntia bioassoy- 3.33 low dose = 50-to 7-5 or 62^3 mg/kg ava-sa^e- /yrn^^ylt^ ^ JO. 0 /2-y ^ high dose = -tOQ- to 175 or 12 mg /kg average. Mousp\ gavage /ifl^pses in NCI bioassay \low dose^ = 7 S' to\ 100/orl 87.5 /me/kg avg(rpga hi^ly'dose = 150 to 200 or i75 mg/kg'average^ 3^ 7. *f Total Rat gavage dose/day (300 g rat) e.m low dose = 18.75 mg/day high dose = 37t5- mg/day " /S~.0 ouse gavage dose/Say (25 g^mduse) low do/e /= 2yl875[mg/da^ lJ f X- ose =3.375 mg/day s ^0% Rat 8-hour Inhalation Equivalent of if for.uptake levels of- 25,50,75 rmd- 100% Rat 8-hour volume = 144 PU8 hours <VW O.ooOH low dose = 18.7-5 mg/144j2= OtIS mg/1 sr / fif 0.63i7^Ji, high dose = -37r5 mg/144 /{ = 0.25 mg/1 ppm (25C) = 24450 m.w. ajoif* vern x mg/1; m.w. (E) = 08- Uptake (a) M.'7[\ lOIO/oAlovA do^6 = u high Udse^= 13.0, V_ 75%\ lovA dos'Si = 4^.2/\pm-^ V high'^-doseVr 86/5 ppm s.y 50% low dose = 54-r8 high dose =120x5"ppm Sr^U low\ dose-\ =12SK 6 ppm y nigh^4ose W59.\2 ppm . , Q. 7. 3 1.5 x weight 21993002 bFG^453 8. Mouse 8-hour Inhalation Equivalent of 6 for uptake levels of 25,50,75 and 100% Mouse 8-hour volume = 18.0 1/8 hours low dose = 2.1875 mg/18 1 = 0.12 mg/1 high dose = 4.375 mg/18 1 = 0.24 mg/1 ppm (25C) = 24450 x mg/1; m.w. (EDC) = 98 m.w. Uptake ( n) I007o low dose = 29.9 ppm high dose = 59.9 ppm 757. low dose = 39.9 ppm high dose = 79.9 ppm 507. low dose = 59.9 ppm high dose = 119.8 ppm 257. low dose = 119.6 ppm high dose = 239.6 ppm 9. Rat 6.5-hour Inhalation Equivalent of 5 for uptake levels of 25,50,75 and 100% Rat 6.5 hour volume = 117 1/6.5 hours low dose =18.75 mg/117 1 = 0.16 mg/1 high dose =37.5 mg/117 1 = 0.32 mg/1 ppm (25C) = 24450 x mg/1; m.w. Uptake (Ct) 100% low dose = 39.9 ppm high dose = 79.8 ppm m.w. (EDC) = 98 757. low dose = 53.2 ppm high dose = 106.4 ppm 50% low dose = 79.8 ppm high dose = 159.6 ppm 257. low dose = 159.6 ppm high dose = 319.2 ppm 10. Mouse 6.5-hour Inhalation Equivalent of 6 for uptake levels of 25,50,75 and 1007. Mouse 6.5-hour volume = 14.6 1/6.5 hours 21993003 low dose = 2.1875 mg/14.6 1 =0.15 mg/], high dose =4.375 mg/14.6 1 = 0.30 mg/1 ppm (25C) = 24450 x mg/1; m.w. (EDC) = 98 m.w. cont'd BFG17454 'r 10. - cont'd Uptake (a) 100% low dose= high dose= 37.4 ppm 74.8 ppm 75% low dose= 49.9 ppm high dose= 99.7 ppm 507 low dose= 74.8 ppm high dose= 149.6 ppm 25%, low dose= 149.6 ppm high dose= 299.2 ppm RKH/KC 1- 21993004 O BFG17455 IMFGoodrich ^ /z--' /^X^ O? y^ ^ __ ________________________ _ 3 <s? un^iiL -~ __ ^y^s&z<t^, /3' Q>-- -------- B^c-I t '29-6 1/77 ^FG17456 4-* CD JL CO O o Ul PRINTED IN U.S.A