Document rB48b6ra0R2ZjJMo0G001XMKa

on BIOLOGICAL EFFECTS OF ASBESTOS Monday, October 19, Tuesday, October 20, and Wednesday, October 21, 1964 THE HEW YORK ACADEMY OF SCIENCES SECTION OF BIOLOGICAL AND MEDICAL SCIENCES 2 East Sixty-third Street New York, N. Y. 10021 The evening session on October 20 will be held at the Academy Building ALL OTHER SESSIONS WILL BE HELD AT The Waldorf-Astoria Park Avenue at 30th Street tNew York, N. Y. Thi* program witl trr* # ticket at admiaaian and ia nontranalarakta. her 0004382 | I Preface of the Conference In the four decades during which there has been acceptance of Dotentiai hazards associated with exposure to asbestos, solutions to the problems involved have been elusive. Therapy of asbestosis remains largely a rearguard bolding action once the diffuse interstitial fibrosis is established. Prophylactic measures are hampered by difficulties in early diagnosis, including the long latent period often noted between onset of exposure and clinical change. Hard won data have been accumulating which indicate that neo plasia associated with asbestos exposure, esoecially those of the lung, are perhaps the most important industrial cancers at this time. This importance has been emphasized by the recent stimulating studies of South African and British investigators demonstrating the significant incidence of pleural and peritoneal tumors associated with asbestos exposure and by the knowledge that the various neo plasms might follow exposure of limited duration and intensity, in adequate to result in significant asbestosis. There have been effective advances in dust control techniques, accomplished by diligent, ingenious and expensive engineering. However, application of these procedures has been hampered by the rapid growth of asbestos utilization, sometimes under circum stances in which exposure has been obscure or unrecognized. More over, community and indirect occupational exposure may occur; the scooe and importance of such "asbestos air pollution" are at pre sent uncertain but their potential significance has attracted atten tion. The foregoing sober inventory provided the stimulus and back ground for this Conference. The Scientific Council of the Academy considered that the interdisciplinary nature of the problem, involving such distinct fields as exoerimental pathology, applied physiology, oncology, epidemiology, and industrial hygiene could best be served bv a broad conference of investigators in the biological sciences and those in allied fields. In October 1963 visits were made by Dr. Selikoff on behalf of the Academy to several European centers to investigate the feasibility and potential scope of such a conference. In particular, British studies were reviewed with Dr. J.C. Gilson, Director of the Medical Research Council Pneumoconiosis Research Unit. The cooperation of Dr. H. Heimann of the Division of Occupational Health of the United States Public Health Service facilitated a survey of current work in this country. HER 0004383 The Academy was forti ference Committee whi " Its members, themselve. January 6, 1964 in New Yo then formulated was refine Committee with the assista; of the world and by July, pleted. It is the hope of the fertile one and will lead problem. July 17, 1964 ORGA> Irving J. Selikoff Jacob Churg, W. Clark Cooper John C. Gilson E. Cuyler Hammond Thomas F. Mancuso E. Lynn Schali William E. Smith Coc Y or Coc Y or Sch orn ' .a A me Gra of ! Occ Sta He: sor 1 acceptance of stos, solutions holding action . Prophylactic >sis, including exposure and .cate that neov those of the 3 at this time, nt stimulating demonstrating 3rs associated ; various neo- mtensity, in- i techniques, engineering, hampered by -indei circumjnizea. Moreay occur; the " are at ?reracted atten- js and backthe Academy ;m, involving physiology, 3t be served al sciences >ehaif of the ; feasibility Lar, British the Medical cooDeration ;alth of the y of current 105104 The Academy was fortunate in securing the advice of a Con ference Committee which encompassed the major areas involved. Its members, themselves actively concerned with the problem, met January 6, 1964 in New York. The preliminary design of a meeting then formulated was refined during the succeeding months by the Committee with the assistance of active investigators in many parts of the world and by July, 1964 the Conference program was com pleted. It is the hope of the Academy that this Conference will be a fertile one and will lead to decisive findings on this important problem. July 17, 1964 Eunice Thomas Miner Executive Director The New York Academy of Sciences ORGANIZING COMMITTEE Irving J. Selikoff Jacob Churg, W. Clark Cooper John C. Gilson E. Cuyler Hammond Thomas F. Mancuso E. Lynn Schall William E. Smith Cochairman; The Mount Sinai Hospital, New York, N. Y. Cochairman; The Mount Sinai Hospital, New York, N. Y. School of Public Health, University of Calif ornia, Berkeley, Calif. Pneumoconiosis Research Unit, Medical Re search Council, Penarth, Glamorgan, Wales American Cancer Society, New York, N. Y. Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa. Occupational Health Program, New Jersey State Department of Health, Trenton, N. J. Health Research Institute, Fairieigh Dickin son University, Madison, N. J. HER 0004384 Conference Cochairmen: I. J. Selikoff and J. Churg The Mount Sinai Hospital New York, N. Y. PROGRAM MONDAY, OCTOBER 19, 1964 Session Chairman: H. J. Magnuson Institute of Industrial Health, University of Michigan Ann Arbor, Mich. 9:00 A.M. Greetings from the Academy - Gabriel G. Nahas, Vice-Chairman, Section of B iological and Medical Sciences, The New York Academy of Sciences; College of Physicians and Surgeons, Columbia Uni versity, New York, N. Y. Opening Remarks -- I. J. Selikoff, The Mount Sinai Hospital, New York, N. Y. ASBESTOS MATERIALS IN MODERN TECHNOLOGY Session Cochairman: P. H. Riordon Asbestos Corporation Limited Thetford Mines, Quebec "The Geology, Occurrences and Major Uses of Asbestos" -- N. W. Hendry, Canadian Jonns-Manville, Ltd., Asbestos, Quebec. "Physical and Molecular Structure of Asbestos" -- R. Gaze, The Cape Asbestos Company, Ltd. (Asbestosis Research Council), London, England. LIVING TISSUE AND MINERAL MATTER: PROBLEMS OF PATHOGENESIS Session Cochairman: I. Webster Pneumoconiosis Research Unit Johannesburg, South Africa PROBLEMS OF IDENTIFICATION OF ASBESTOS IN HUMAN TISSUE; PANEL DISCUSSION MODERATOR: P. Gross, Industrial Hygiene Foundation, Pittsburgh, HER 0004385 ``Identification b Activated Or-- Mount Sinai 1 "Identification o Human Lung Ti: College of .Medic "Dust Content a G, Nagelschmidt Sheffield, Englan EX MODERATOR: J. C coniosis Researc "Asbestos Dust Wagner and J. W Unit, Glamorgan, "Experimental A tance of Particle Research Counc "Electron Micro mais" - J. M. G versify of Cambr "Rheumatoid Factor B. Perms and E. C. I. J. Selikoff, The M "Observations t liani and 3. Per....,, 12:30 P.M. Luncheon HUM ASBESTC : Ses ; M.R.C i 2:00 P.M. - " Asbestosis in the Pensions and N'atior. n: >ital , 1964 agnuson :rsity of Michigan . Manas, Vice-Chairman, The Mew York Academy Surgeons, Columbia Uni- >unt Sinai Hospital, Mew ?N TECHNOLOGY Riordon mited ec es r soestos" - N. W. besi. Quebec, bestos" - R. Gaze, The :>sis Research Council), L MATTER: 1ENESIS /ebster :n Unit trie a 3F AS3EST0S IN SCUSSION i Foundation, Pittsburgh, "Identification by Fluorescent Dye Staining and Electronically Activated Oxygen Ashing" -- C, Berkley and J. Churg, The Mount Sinai Hosoital, New York, N. Y. "Identification of the Several Varieties of Asbestos Fibers in Human Lung Tissue" -- A. Vorwald, Wayne State University College of Medicine, Detroit, Mich. "Dust Content and Composition in Langs with Asbestosis" G. Nagelschmidt, Safety in Mines Research Establishment, \ Sheffield, England. EXPERIMENTAL ASBESTOSIS PANEL DISCUSSION MODERATOR: J. C/wagneOMedical Research Council Pneumo coniosis Research^tfwitrGlaraorgan, Wales. "Asbestos Dust Deposition and Retention in Animals" - j. C. Wagner and J. W. Skidmore, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. "Experimental Asbestosis with Three Types of Fibers: Impor tance of Particle Size" -- J. Mills and P. F. Holt,(Asbestosis Research Council), University of Reading, Reading, England. "Electron Microscooic Studies of Asbestosis in Man and Ani mals" -- J. M. G. Davies, (Asbestosis Research Council), Uni versity of Cambridge, Cambridge, England. "Rheumatoid F actor in Serum of Individuals Exposed to Asbestos" B. Pernis and E. C. Vigliani, University of Milan, Milan, Itaiy, and I. J. Selikoff, The Mount Sinai Hospital, New York, N. Y. "Observations on the Pathogenesis of Asbestosis" -- E. C. Vigliani and B. Pernis, University of Milan, Milan, Italy. 12:30 P.M. - Luncheon Session Chairman: J. H. Sterner Eastman Kodak Company Rochester, N. Y. % HUMAN EXPOSURE TO ASBESTOS: ASBESTOSIS IN INDUSTRIAL POPULATIONS J Session Cochairman: J. C. Gilson M.R.C. Pneumoconiosis Research Unit Glamorgan, Wales 2:00 P.M. - "Asbestosis in the United Kingdom" - J. C. McVittie, .Ministry of Pensions and National Insurance, London, England. i i. i. HER 0004386 "Asbestosis Among Insulation Workers in the United States" -- (. J. Selikoff, J. Churg, and E. C. Hammond, The Mount Sinai Hospital, New York, N. Y. ``Mortality Rates Among Asbestos Products Workers in the United States" - P. Enterline, U. S. Public Health Service, Washington, D. C. "Secular Changes in Asbestosis in an Asbestos Factory" -- W. J. Smither, (Asbestosis Research Council), The Cape Asbestos Com pany, Ltd., London, England. HUMAN EXPOSURE TO ASBESTOS: COMMUNITY STUDIES Session Cochairman: J. Higginson University of Kansas School of Medicine Kansas City, Kan. "Occupational and Nonoccupational Exposure to Asbestos" - W. C. Hueper, National Cancer institute, Bethesda, Md. "Prevalence of Asbestos Bodies in Autopsy Cases" -- J.C.Thom- >V son, University of CapeTown, CapeTown, South Africa. /\ "Asbestosis: Geographical and Environmental Studies in South Africa" -- G. K. Sluis Cremer, Pneumoconiosis Bureau, Johannes burg, South Africa. "Pleural Ptaoues and Asbestos: Further Observations on Endemic and other Nonoccupational Asbestosis" -- R. Kiviiuoto, Tampere Central Hospital, Tampere, Finland. Session Chairman: J. H. Wolfsie United States Rubber Company i7^"VNew York, N, Y. /> ylj"\s . l s' '/> ' '/'Session Cochairman: L. Cralley iK'S.P.H.S. Occupational Health Research and Training Facility / Cincinnati, Ohio ^-- "v 8:00 P..M. - IaTTon of Fibrous Dusts" -- V. Timbrell, M.R.C. Pneumo coniosis Research Unit, Glamorgan, Wales. "Comparison of Impinger and Membrane Filter Techniques for Eval uating Air Samples in Asbestos Plants" -- H. E. Ayer, Division of Occupational Health, U. S. Public Health Service, Washington, D.C. "Developments in Dust Sampling and Counting Techniques in the Asbestos Industry" - S. Holmes, (Asbestosis Research Council), Turner Brothers Asbestos Company, Ltd. Rochdale, England. HER 0004387 "Dust Measurem C. G. Addingley and Asbesto "Measurement ot Different Parame Topical Medicine Discussion oper burgh. Pa. Jersey State Deo; "Economics of 0 NCouncil), Turner land. Schoc "Radiological Cl Municipal Hospite "Roentgenologic; I. J. Selikoff, Thi "Differential Die Welsh National 5 "Roentgenologic tosis in the Unit* 3romoton Hospit National Insurant Theron, f ueumoc Disscussion oper ford M :.ies, Quebt Johannesbure, So- ntheUnited States" -- I. J. The Mount Sinai Hospital. uct. orkers in the United ealth Service, Washington, \sbestos Factory" -- W. J. , The Cape Asbestos Com- COMMUNITY STUDIES Higginson )1 of Medicine m. oosure to Asbestos" -- W. thesda, Md. opsy Cases" -- J.C.Thom, South Africa. onmental Studies in South :oniosis Bureau, Johannes* r Observations on Endemic ' -- R. Kiviluoto, Tampere i. V je 'ompanv . Cralley :ch and Training Facility o imbreli, M.R.C. Pneumos. ilter Techniques for Eval-- H. E. Ayer, Division of Service. Washington, D.C., hunting Techniques in the stosis Research Council),. Rochdale, England. "Dust Measurements and Monitoring in the Asbestos Industry" C. G. Addingley, (Asbestosis Research Council), British Belting and Asbestos, Ltd., Yorkshire, England. "Measurement of Airborn Asbestos Dust by Instruments Measuring Different Parameters" -- S. A. Roach, London School of Hygiene and Topical Medicine, University of London, London. England. Discussion opened by T. Hatch, University of Pittsburgh, Pitts burgh, Pa. TUESDAY, OCTOBER 20, 1964 Session Chairman: Harriet L. Hardy /~j Massachusetts Institute of Technology Cambridge, Mass. UST CONTROLS AND STANDARDS 9:00 A.M. "Present Threshold Limit Value in the U. S. A. for Asbestos Dust: A Critique" -- E. L. Schall, Occupational Health Program, New Jersey State Department of Health, Trenton, N. J. -"Economics of Dust Control" -- D. W. Hills, (Asbestosis Research N'Council), Turner Brothers Asbestos Company, Ltd., Rochdale, Eng land. Session Cochairman: L. Silverman School of Public Health, Harvard University Boston, Mass. PULMONARY ASBESTOSIS "Radiological Classification of Pulmonary Asbestosis" -- H. Bohlig, Municipal Hospital, Ludensneid, Germany. "Roentgenological Studies of Pleural Calcification in Asbestosis" I. J. Selikoff, The Mount Sinai Hospital, New York, N. Y. "Differential Diagnosis in the Pathology of Asbestosis" -- J. Gough, Welsh National School of Medicine, Cardiff, Wales. "Roentgenological-Pathological Correlations in Pulmonary Asbes tosis in the United Kingdom and South Africa" -- K. F. W. Hinson, Brompton Hospital and J. C. McVittie, Ministry of Pensions and National Insurance, London, England; G. K. Sluis Cremer and C. P. Theron, F ueumoconiosis Bureau, Johannesburg, South Africa. Disscussion opened by P. Cartier, Thetford Industrial Clinic, Thetford Mines, Quebec, and I. Webster, Pneumoconiosis Research Unit, Johannesburg, South Africa. j HER 0004388 PULMONARY FUNCTION IN AS8EST0SIS PANEL DISCUSSION MODERATOR: G. L. Leathart, University of Newcastle, Newcastle, England. "Pulmonary Function in Asbestosis: Serial Tests in Long Term Prospective Study" -- M. Bader, R. Bader and A. Tierstein, The Mount Sinai Hospital, New York, N. Y. "Routine Lung Function Studies of S30 Employees in an As bestos Processing Factory" -- R. Hunt, (Asbestosis Research Council), British Belting and Asbestos, Ltd., Yorkshire, Eng land. "The Discriminant Value of Pulmonary Function Tests in As bestosis" -- M. L. Thomson, W. J. Smither, Anne-Marie Pelzer and M. Hills, London School of Hygiene and Tropical Medicine, University of London, London, and The Cape Asbestos Com pany, Barking, Essex, England. Discussion opened by J. L. Whittenberger, School of Public Health, Harvard University Boston, Mass. 12:30 P.M. Luncheon Session Chatman.' W. C. Cooper School of Public Health, University of California Berkeley, Calif. ASBESTOS AND NEOPLASIA: EXPERIMENTAL Session Cochaitman: Katherine R. Boucot Woman's Medical College of Pennsylvania Philadelphia, Pa. 2:00 P.M. "Studies of Carcinogenesis of Asbestos Fibers and Their Natural Oils" -- J. S. Harington and F. J. C. Roe, Chester Beatty Research Institute, Royal Cancer Hospital, London, England. "Preparation of Asbestos Fibers for Experimental Use" -- M. S. 3adoilet,Health Research Institute,Fairieigh Dickinson University, Madison, N. J., and W. A. Gantt, Occupational Health Program, N. J. State Department of Health, Trenton, M. J. "Tests for Carcinogenicity of Asbestos" -- W. E. Smith and Llonas Miller, Health Research Institute, Fairieigh Dickinson University* Madison, N. J. "Tests for Effect of Asbestos on Benzo (a) Pyrene Carcinogenesis HER 0004389 in the Respiratory Tr; leigh Dickinson Unive: Discussion ooene search Unit, Glam<. ASBESTOS Sess; The C "Asbestosis and Bror W. D. Buchanan. Minis "Neoplasia Among Ir Special Reference to [ I. J. Selikoff, and J. N. Y. "Cohort Analysis of C in a Textile Asbestos Council), Turner Brot: R. S. Doll, M. R. C. "Pulmonatv Neoplasi. Jacob, Krankennaus, K Occupational Health, 1 "The Relationship of in Belfast" - P. C. Belfast, Northern IreU "Association of Pair Northern Italy" University of Tu. , cupational Diseases, ' Disscussion opened b burgh. Pa., and G. W rensic Medicine, Wash 6:00 P.M. Cocktail Hour -- Acac York, N. Y. 7:00 P.M. Informal Subscription Kevnote Address TOSIS :astle, Newcastle, ests in Long Term and A. Tierstein, ployees in an AsAsbestosis Research Yorkshire, Eng- iction Tests in AsAnne-Marie Pelzer Tropical Medicine, ape Asbestos Com- of Public Health, aiifornia -1ENTAL oucot vania and Their Natural er Beatty Research nd. nial Use" -- M. S. kinson University, eaith Program, N. . Smith and Llonas kinson University* ne Carcinogenesis in the Respiratory Tract" - Llonas Miller and W. E. Smith, Fair- leigh Dickinson University, Madison, N. J. J/ Discussion opened by J. C. Wagner, M.R.C. Pneumoconiosis Re search Unit, Glamorgan, Wales. \f jU ASBESTOS AND NEOPLASIA: EPIDEMIOLOGY ' Session Cochairwan: W. J. Smither The Cape Asbestos Company, Ltd. London, England / "Asbestosis and Bronchial Carcinoma" -- T. A. Lloyd Davies and W. D. Buchanan, Ministry of Labour, London, England. "Neoplasia Among Insulation Workers in the United States with Special Reference to Intra-abdominal Neoplasia" -- E. C. Hammond, 1. J. Selikoff, and J. Churg, The Mount Sinai Hospital, New York, N. Y. "Cohort Analysis of Changes in Incidence of Bronchial Carcinoma in a Textile Asbestos Factory"--J. F. Knox, (Asbestosis Research Council), Turner Brothers Asbestos Company, Ltd., Rochdale, and R. S. Doll, M. R. C. Statistical Research Unit, London, England. "Pulmonary Neoplasia Among Dresden Asbestos Workers" -- G. Jacob, Krankenhaus, Karl Marx Stadt, and M. Amspach, Institute of Occupational Health, Dresden, G.D.R. "The Relationship of Exposure to Asbestos to Pleural Malignancy in 3elfast" -- P. C. lines and 0. L. Wade, Queen's University, Belfast, Northern Ireland. "Association of Pulmonary Neoplasms with Asbestos Exposure in Northern Italy" - E. C. Vigliani, University of Milan, G. Mottura, University of Turin, and P. Maranzana, National Institute of Oc cupational Diseases, Lombardy, Italy. Disscussion opened by T. Mancuso, University of Pittsburgh, Pitts burgh, Pa., and G. W. H. Schepers, Institute of Industrial and Fo rensic Medicine, Washington, D. C. 6:00 P..M. - Cocktail Hour -- Academy Building, 2 East Sixty-third Street, New York, N. Y. 7:00 P.M. Informal Subscription Dinner -- Academy Building Keynote Address: J. C. Gilson, Medical Research Council, Pneumoconiosis Research Unit, Glamorgan, Wales. HER 0004390 WEDNESDAY, OCTOBER 21, 1964 Session Chairman: H. L. Stewart National Cancer Institute, Bethesda, Md. 9:00 A.M. "Epidemiology of Diffuse Mesothelial Tumors: Evidence of an As sociation from Studies in South Africa and the United Kingdom" -- J. C. Wagner, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. "Epidemiological Studies of Patients with Mesothelial Tumors in the London Area" -- Muriel L. Newhouse, School of Hygiene and Tropical Medicine, University of London, London, England. DIFFUSE MESOTHELIAL TUMORS PANEL DISCUSSION MODERATOR: W. U. Gardner, Yale University School of Medicine, New Haven, Conn. "Criteria for Diagnosis of Diffuse Mesothelial Tumors" -- W. T. E. McCaughey, Queen's University, Belfast, Northern Ireland. "Histological Chacteristics of Mesothelioma Associated with Asbestos" - J. Churg, The Mount Sinai Hospital, New York, N. Y., S. Moolten, Middlesex General Hospital, New Brunswick, N. J., and S. Rosen, Armed Forces Institute of Pathology, Wash ington, D. C. "Mesothelial Tumors in South Africa: Pathology and Experi mental Pathology"--I. Webster, Pneumoconiosis Research Unit, Johannesburg, South Africa. "A Biopsy Series of Mesotheliomata and Attempts to Identify Asbestos within Some of the Tumours" -- D. O.'B. Hourihane, London Hospital Medical School, London, England. "Pleural Mesothelial Tumors and Exposure to Asbestos Dust" -- W. Glynn Owen, Broadgreen Hospital, Liverpool, England. Discussion opened by A. Purdy Stout, Columbia University College of Physicians and Surgeons, New York, N. Y. 12:30 P.M. Luncheon Session Chairman: E. C. Vigliani University of Milan, Milan, Italy PROBLEMS AND PERSPECTIVES 2:00 P.M. "Trends in the Health of the Asbestos Worker" -- K. W. Smith, JohnsManvilie Corporation Manville, N. J. HER 0004391 "Sequelae of Asb Pneumoconiosis Re "Changing Harare M.R.C. Pneumoc ' "Multiple F actors . -- E. C. Hamm ond. The Section c ferences for acti medicine. This conferer. Academy, all piiv icai students, as SECTION i. Preston L. Petlrr Chairman :i, 1964 tewart ht , Md. ors: Evidence of an Asthe United Kingdom" -- :arch Unit, Glamorgan, Mesothelial Tumors in School of Hygiene and ondon, England. TUMORS 1 sity School of Medicine, thelial Tumors" -- W. T. fast, Northern Ireland, .elioma Associated with iai Hospital, New York, ospital. New Brunswick, itute of Pathology, Wash- Pathoiogy and Experiaconiosis Research Unit, md 'empts to Identify 3" . O.'B. Hourihane, m, England. sure to A sbestos Dust" -- .iverpool, England, mbia University College Y. 1 igliani 1, Italy CTIVES er" -- K. W. Smith, Johns- ASi "Sequelae of Asbestos Dust Exposure" -- J. C. Vagner, M.R.C. Pneumoconiosis Research Unit, Glamorgan, Wales. "Changing Hazards of Asbestos Dust Exosure" -- J. C. Gilson, M.R.C. Pneumoconoiosis Research Unit, Glamorgan, Wales. "Multiple Factors in Relation to Neoplasia Among Asbestos Workers" -- E. C. Hammond, The Mount Sinai Hospital, New York, N. Y. PANEL DISCUSSION Moderator: H. Heimann Division of Occupational Health U. S. Public Health Service Washington, D. C. The Section of Biological and Medical Sciences provides con ferences for active workers in the special fields of biology and medicine. This conference may be attended by interested Members of the Academy, all physicians, research scientists, and science and med ical students, as well as those invited to participate. SECTION OF BIOLOGICAL AND MEDICAL SCIENCES Preston L. Perlman Chairman Gabriel G. Nanas Vice-Chairman HER 0004392