Document r8bNanG908jmpGv8GaJ2Rynq

Lo ARR26G -- 1363 ! OPRIMEDICA g#us58Divisuion i30s5 SiheshyaDsriive, Bid A Horsham, A 19044 ECEIVE OCT | 3 20m October 12, 2000 Marvin T. Case, D.VM, Ph.D. 3M Toxicology Services 3M Center, Building 220-2E-02 St. Paul, Minnesota. 55144-1000 Telephone: (651) 733-5180 Telefax: (651) 733-1773 RE: Protocol 418-009 - Combined Oral(Gavage) Fertility, Developmental and Perinatal/Postnatal Reproduction Toxicity StudyofN-EFOSE in Rats DearDr. Case: Enclosed is a copy of the issued final Report Amendment 1 10 the above-referenced protocol. 1fyou have any questions, please do not hesitate to contact me. . Sincerely, RGYg Ene. G York, Ph.D., DABT Associate DirectorofResearch and Study Director 001711 Pimedics Corporation {mon prinadics. com : 7,~PPRRII2MEDICA HTRapSea Argus Research Laboratories, Inc REPORT AMENDMENT 1 12 OCTOBER 2000 PROTOCOL 418-009 COMBINED ORAL (GAVAGE) FERTILITY, DEVELOPMENTAL AND PERINATAL/POSTNATAL REPRODUCTION TOXICITY STUDY OF N-ETFOSE IN RATS FINAL REPORT Attached is the corrected Text Figure 1 to the above-referenced final report. This change reflects `the addition ofa notationforthe dosage administration ofthe F1 generation rats and did not affect the results of the study. 2. Rayiond Associate G. York, Director PH, of DABT Research Date and Study Director Cp J e fer2 (ubstp. ) {' Yksa oSoe 12 acr00 (|Ma<aNnaangceyJr.oGfonRgelgiuelwastkoiry Date Compliance 001/12 : ol a REVISED PAGE i Jk Hie HE NER ijl iil ; ul--m I ET UE pt ee - iPh ! --` li iifi ! - h |-- PPop= I i : -- : i: Hi i i : -- ij I t Pola te : i : i [ET i TE gd = Hii k \ |1 iiikl HifH i Ji git 2 ' uV1/13