Document r7DZR6w2r7yNK0DOGgY9DVae

Proposed Studies on the Risk of Benzene-Induced Diseases in China [APG] Goal: To form a consortium in order to fund research on benzene-exposed workers in China. Purpose: To gain an accurate understanding of the true relationship between benzene exposure and the risk of disease. This study would lead to improved benzene-exposed worker safety by providing the regulatory and scientific communities with information for more accurate assessment of the risks from exposure to benzene. High exposures Benzene-induced disease Good records since 1970s Technology sophistication Willing collaborators Influential contacts \I Challenges: The proposed Technical - In order t incorporate the latest progress in changing the Ethical - To address the e Benefits: Information gained from this project will hav airect oss- e impact upon regulatory standard designed to protect workers and the gener opula n from benzene-induced disease in the West an in China. These include air and water qual y s aards as well as hazardous waste and site remediatio standards. The information gained from th se studies will assist contributing companies in achievin product stewardship goals and will be useful in defending the industry's risk reduction program . Additional benefits from this collaborative approach is outlined below. Benefits of Extensive Collaboration Import. Acquires Study Methods Expertise Enhances Professional AdvancementPublications Imports. Leading Technology. Know-How Broadens Training Opportunities '--------------1 Allows Greater Autonomy in Future 02/06/01 Required to Navigate Socio-Political Infrastructure Ensures Adequate Participation Enhances Study Impact. Relevance Improves Business-Regulatory Interface in China Establishes Partner Spokespersons CGU BEN0000521 Proposed Studies on the Risk of Benzene-Induced Diseases in China [APG] The Studies: Three inter-related studies have been proposed for this project: Case-Control Study - A hospital-based case control study to investigate the potential relationship between benzene exposure and both Non-Hodgkins Lymphoma Shanghai Benzene Study Structure (NHL) and Acute Myelogenous Leukemia (AML), including an attempt to quantify the potency of benzene for the AML response. case-Control Study Disease Progression Study Molecular Epidemiology Study Disease Progression Study - A ospital/clinic-based investigation of the relations be ween non-cancer diseases of the bone m ow and (cancer) to determine if effect on bo marro cytotoxicity tages an ul mate eukemia. This pt to efine pot cy and the Costs: The estimated cos 2001 U.S. Dollars project were derived aft Seed Monies $500,000 consideration of all technical, ethical, and politica issues. Therefore, the estimat Study Costs Case-Control Study Disease Progression Study Molecular Epidemiology Study $1,761,000 $3,494,000 $3,275,000 costs are fairly stable and are ot Hematological Laboratory in Shanghai $8,340,000 anticipated to increase by muc ' \ Other Costs (Administrative, Travel, Ethics Panel, except due to inflation. f--___S_c_ie_n_ti_fi_c_Ov_er_s__,ig'-h_tP_an_e--'-l)_ _ _ _ _ _--+_ _$_1--'-,_34_1-'-,o_o_o_, GRAND TOTAL $18,713,000 Funding: Funding for the project will be handled by canso rested stakeholders, with share determined by size of the contributing orga ation. e fundi g formula was devised based on th assumption that most support will come om t etroleum and petrochemical industries, and that t will take five years to complete the project, the costs will be highest in the first years of the project. Funding Formula Share Determination Shareholder Category Shares U.S. Refiner (based on U.S. refinery capacity)* Small (0: 500,000 bb1/day) Medium (>500,000 and 0: 1,500,000 bb1/day) Large(> 1,500,000 bbl/day) 1 2 3 Non-U.S. Refiners (no U.S. refineries) 1 Free-Standing Chemical Co. (No refineries) 2 Upstream Company (No refineries) 1 Other (trade association, government, NGO) Negotiable *U.S. refinery capacity will be deternuned based upon refinery ownership as of October 1, 2000. Capacity will be calculated using the Oil and Gas Journal's 2000 Penuwell Directory. 02/06/01 Example Funding Formula By Project Year Stud Year Percent of Costs Cost Per Share 1 30 $401,100 2 25 $334,250 3 15 $200,550 4 15 $200,550 5 15 $200,550 Total: $1,337,000 Assumes that there are a total of 14 Shares at approximately $1,337,000 per share. Costs per share may increase or decrease dependent upon participation level (i.e., total number of shares). CGU BEN0000522