Document r6xzmpwb7zwny4rrRkn06LB67

*iO*eST B$A*c* i'lHt C- * w.*** V*1 5 ' *0*** H4. S4-":*C2 7 June 11, 1971 Royal A. 3ron Technical director National Paint and Coating Association 1500 Rhode Island Avenue, S.W, Washington, 3. C. 20005 AT Subject: Letter Report, MRI Project Mo. 3729-8, "Lead Ingestion Study," Dear Hr. Brown: This is a preliminary report on the first 8 weeks of the lead paint study results. In review, rats art being fed one of the following substances nixed in purlna rat mash at the concentration of 0.17.. Dried Faint Film Lead Content in Feed (ut Pb/m Feed! Theoretical Measured 1. Without Lead 2. Containing 0.06Z Lead oetoate 3. Containing O.JX Lead Oetoate A. Containing 2.OX Lead Oetoate 5. Containing 0.5X Lead Chroaate 6. Containing 2.OX Lead Chromate 7. Containing 15.01 Lead Chromate 8. 64X Lead Carbonate 9. 121 Powdered Lead-Baaed Peine (NetionaL Bureau of Standards) -4. A 8.8 23.8 6.8 23.6 153.8 643.8 118.7 3.8 5.0 8.0 28.0 6.0 18.5 299.0 891.0 138.0 The first eight group* have been euthanatized and all chuical analysis should ba complete by June 13. Croup 9 will be euthanatized during the weak of July 9th. Tabulations of food consumption and body weight gain ere hoc completed. Although thera appear to bo no gross differences between group*, ve eaaaot draw any final conclusions until all eba data are tab ulated and eaaead statistically. Of the various testa being performed, the following appear normal after 8 weeks: ur.' ir,.; -- &*S2*rc**iV 0007--SWP-036782 N22961 Royal a . 3rcvn 2 June II, i?*3 Hematocrit , Hemoglobin Erythrocyte end leukocyte count Reticulocyte count* Differential leukocyte count* Blood protoporphyrin Erythrocyte oeaotic fragility Electrophoretic pattern* o plun protein* Urlnaiyd* Urinary {-aminolevulinic eeid (ALA) Urinary coproporphyria Delte-eniinolevullnie *cid dahydraaa (ALAS) activity va* depreaaed approx* irately 501 *t 4 and 8 week* in the lead carbonate (roup (No. 3). ALAD activi* tie* vert normal in group* 1 through 7. ALaO Eer group 9 at 4 week* al*o appeared normal. The tlaiua lav*la (blood, bone, kidney, liver and brain) of laad uera ilmllar in group* 1 through 7. In group 4, bon* laad va* tlavacad two- and thraafold, while blood lead va* at control laval*. Laad tlu* levela in group 9 hav* not baen eomplatad. Thera hava been no groia behavioral aign* which are traatsant* relatad. Llkavisa, no craitaant-relatad difference* vara obearvad during nteropiy. We expect to finiah all analyai* and calculation* on groupa 1 through S is thra* more waaka. Tha final report will not be forthroning until the lattar part .of July line* group 9 ttill ha* 5 week* rtsainlng. I alnearely hop* thi* preliminary report i* helpful. Do not heaitata to call if you vane additional information. Sintartly, Approved; KtSWEST RESEARCH INSTITUTE ---- U. B. Boua*. Director Biological Science* Divltioc Thomaa R. Caatlea, Fb.D. Principal fharxaeelogijt it*'"'***'. Ai 5'' $45'* Ai"A T y-Z- 0007-SWP-036783 0007-SWP-000113040