Document r6mmOVx0Lo2MN4J0dV97Q6DpV

WmBEsrosis and lung cancer jF'C'. Table 2.--Mode of Exposure and Carcinoma ... Mode of Exposure No. of Cases (32) No. With Tumor (10) available. Sections and eosin and with diagnosis had been ixposure, gross apd diffuse interstitial -.stos fibers and/or iw^:..'fabricators ^;/';Vp,roc6S3 workers -.Miners 33 from main bronchi, distal air passages, to l,'{'The pleura. The following cases have been ^'-pfeviously published: case 3, Clinico-Patho- logical Conference, Massachusetts General Is of the ten cases Hospital, 1947; case 2, Isselbacher et al, 1953; and case 8, Jones Williams, 1957. In ixception all were a maximum num- . (he present series, particular attention was '^Ipcused on the bronchial epithelium. Five Hails of exposure cinoma cases: six cases showed well-marked squamous meta plasia of main bronchi; three of these were workers, and one ^associated with carcinoma but only one was iows the. exposure te total scries: 33 workers, and six squamous, and the other two were adenoyvAcarcinoniata. Four of the five showed wellji'T,'marked bronchiectasis. I have previously the distribution of . Fabricators in- i discussed and illustrated (1957) changes in hjhe peripheral alveolar epithelium in this ipinners, and in workers are those g asbestos fibers ;n of exposure of exception, was 12 tl series the range 3 with less and 17 tx posu re. showed various ;, three; anaplastic, :wo; alveolar cell thelioma of pleura, ible sites of origin, ^'series. In ten of the 52 cases there was con- ^h'.cp'rnitant tuberculosis (19.2%), all without F-'carcinoma. With two exceptions, both having ^subapical cavitation, all showed extensive ` crculous bronchopneumonia which was |ifie cause of death. In the majority, ^Tuberculosis developed a considerable time Rafter the diagnosis of asbestosis. Histo rically, there appeared to be no modification jj/yjSf the tuberculous reaction by the underlying |Tlust fibrosis. w/TTwo of the ten had silicosis to a minor One was an asbestos miner and the e, Sex, Exposure, listology Mother was exposed to silica (lour in the manu re of asbestos pipes. In the total series (where were four others with silicosis, a total tlon I-IJatoIoffy 5-1:six of 52 (11%). Anaplastic Adenocarcinoma Squamous Endothelioma pleurai Adonocnrclnoitm Squamous Anaplastic Alveolar cell \ Squamous ( Anaplastic Conclusion WvThis report records 52 American cases of Mpestosis among whom there were ten pajj&nts with malignant tumors, an incidence (Pilar to that reported in Britain. fany American pathologists permitted access to jjijt;', material and records. J- Jones Williams, MD, Institute of Pathology, ^fjsh National School of Medicine, Cardiff, Wales. fa-Williams 45 REFERENCES 1. Anderson, ]., and Campagna, F. A.: Asbes tosis and Carcinoma of Lung: Case Report and Review of Literature, Arch Environ Health 1:2732, 1960. 2. Annual Report of Chief Inspector of Fac tories for 1958, London: Her Majesty's Stationery Office, 1959, p 45. 3. Clinico-Pathological Conference of Massachu setts General Hospital, New Eng J Med 236:407412, 1947. 4. Cordova, J. F.; Tesluk, H.; and Knudtson, K. P.: Asbestosis and Carcinoma of Lung, Cancer 15:1181-1187, 1962, 5. Doll, R.: Mortality From Lung Cancer in As bestos Workers, Brit J Industr Med 12:81-86, 1955. 6. Egbert, D. S., and Geiger, A. J.: Pulmonary Asbestosis and Carcinoma: Report of Case With Necropsy Findings, Amer Rev Tuberc 34:143-150, 1936. 7. Gloyne, S. R.: Pneumoconiosis: Histological Survey of Necropsy Material in 1205 Cases, Lancet 1:810-814, 1951. 8. Hannon, J. W. 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