Document r663kyEvDBRonKR9O6KD8m9J

R&S 13833 Print 1-858 DIALOG FI 1e5: BIOSIS Previews 77-83/Jan BA7502;RRM2402{See Flle55) (c. BIOSIS 1982) (Item 1 of 858) User 3614 25jan83 1980 75014232 ACINETOBACTER HOSPITALS. ISOLATES FROM ENVIRONMENTAL SAMPLING IN OHGKE H; STEINKOHL M; KANZ E AST. KRANKENHAUSHYG.. INST. MED., MIKROBIOL. IMMUNOL.. UNI VERS IT AET SKRANKENHAUS EPPENDORF, HAMBURG 20. MARTINISTR. 52. D-2DOO ZENTRALBL BAKTERIOL MIKROBIOL HYG ABT 1 ORIG 8 HYG UMWELTHYG KRANKENHAUSHYG AR8EITSHYG PRAEV MED 174 (6). 1981 (RECD. 1982). 509-522. Coden: ZAOMO Language: GERMAN By environmental culturing. Actnetobacter was Isolated from human sources and wet sites as well as from air and dry surfaces. A. anltratum from patients and hospital personnel, resistance against antibiotics and metal salts was more dominant than In other strains. Ac 1netobacter strains were more tolerant of dryness than Escherichia coll but less than Micrococcus luteus. By repeated contacts, Ac I netobacter spp. were recovered from contaminated surfaces of polyvinyl chloride in significantly higher numbers than from paving tile. Descriptors: HUMAN ACINETOBACTER-ANITRATUM ESCHERI CHI A-COL I MICROCOCCUS-LUTEUS HOSPITAL PERSONNEL AIR WET SITE DRY SURFACE ANTIBIOTIC RESISTANCE METAL SALT POLY VINYL CHLORIDE PAVING TILE Concept Codes: MATHEMATIC BIOL/STATISTIC METH{04500): BIOCHEM STUD-GENERALt 10060): MINERALS(10069); PATHOLOGY-THERA- PY( 12512); PHARMACOL-GENERAL STUD IES(*22002); PHARMACOL-CL INI- CAL PHARMACOL(22005); BACTERIA-PHYSIOLOGY,BIOCHEMISTRY(*31000) : MICROBIDLOG APPARAT,METHS.MEDI A(32000); MED/CLIN MICROBIOL-GEN.METH,TECH(36001); MED/CLIN MICROS IOL-BACTERIOLO- GY(*36002): PUB HEALTH-ADMINISTR,STATI STICS(*370iO); PUB HEALTH-HEALTH SERV.MEDL CARE(*37012); ENVIRON HEALTH-A IR.WATR- ,SL POLLN(*37015); EPI DEMIOL-COMMUNICABLE 0 ISEASES( 37052); PUB HEALTH-GENL DISEASE VECTORS{*37057); PUB HEALTH-AN I MATE DIS VECTORS(*37058); PUB HEALTH-INANIMATE CIS VECTORS{*37060); PUB HEALTH MICROBIOL(37400); CHEMOTHERAPY-ANTIBACTERIAL AGNTSt *38504) Blosystemat1c Codes: ENTER08ACTERI ACEAE{04810); NEISSERI ACE - AE(05 MO); HOMINIDAE(B6215) with a rotating paddle method (USP XX). A 1st order rate constant correlated better than a single point estimate {t70%). Correlations to In vivo by using Cp max [maximum plasma concentration after single dose administration) and AUC [are a under the curve] were shown. Descriptors: PLASMA ALAPROCLATE HYDRO CHLORIDE SINGLE POINT ESTIMATE PHARMACO KINETICS Concept Codes: MATHEMATIC 8 IOL/STATISTIC METHC04500); BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH( 10504); B[OPHY S-MOLECUL PROP.MACROMOLEC{* 10506); MOVEMEN- T{ 12 100); MET ABOLISM-GENL STUD,ME T AB PATHW( 13002); BLOOD/BODY FLOS-BLOOD.LYMPH STUO( 15002); PHARMACOL-GENERAL STUDIES{ * 2200- 2); PHARMACOL-DRUG MET AB.MET AB ST1MU{* 22003) 75013043 A ROTATING DISC METHOD TO DETERMINE DRUG DISSOLUTION RATES FROM INERT POLY VINYL CHLORIDE MATRICES. NICKLASSON M; BRODIN A; GRAFFNER C DTP. PHARMACEUTICS, ASTRA LAKEMEOEL AB, S-151 85 SODERTALJE, SWEDEN. ACTA PHAtfM SUEC 19 (3). 1982. 211-222. Coden: APSXA Language: ENGLISH A rotating disk method using an extrapo1 at1 on procedure was used to study the influence of some. Insoluble excipients on the dissolution rate of alaproclate HC1 from PVC lpolyv1nylchoride] matrices. Both initial and matrix controlled release were determined. The matrix controlled release correlated well with dissolution experiments performed DIALOG R&S 138335 e5: BIOS IS Previews 77-83/Jan BA7502:RRM2402{See Flle55 (c. BI05IS 1982) {Item 3 of 858) User 3614 25Jan83 198 I 75008555 A NEW ATTEMPT FOR MVO CARDIAL COOLING DURING CARDIAC SURGERY. MAETA H; IRIYAMA T; ITOH T; OKAMURA K; IJIMA H; SAKURAI J-I; MITSUr T; HORI M DEP. SURG., INST. CLIN. MED.. UNIV. TSUKUBA. 0 JPN ASSOC THORAC SURG NK Z A A 30 (1). 1982. 21-27. Codon: Language: JAPANESE A combination of the topical myocardial cooling and the cold cardioplegia has now become a routine method for myocardial preservation. Rapid uniform cooling of the heart and keeping myocardium In Ideal hypothermia are the most important requirements of myocardial protection during cardiac surgery. A new super f1ne myocard 1 a I thermosenser and a cooling coil which showed good results In clinical use was designed. The superfine myocardial thermosensor (MTS) Is made of string-typed thermocouples (chrome 1 a 1umo1) covered with Inconel. It is only 0.25 mm thick and can be Inserted Into any depth or any part of myoerdiaum. Relationship between the electromotive force and the temperature meausred by a mercury thermometer had an excellent correlation at over 7.degree. C. The MTS Is fixed firmly enough with only 1 suture to the myocardium and Is removable easily and safely under the heart beating. Myocardial cooling coll is made of a vinyl chloride tube (5 mm in diameter) and formed like a basket. The left ventricle Is wrapped by this coll and lifted up from the pericardium. This coll Is connected to a heat-exchanger and a roller pump. The pericardial cavity Is irrigated continuously with cold saline through the coil. Overf1 owed water is aspirated by another suction tube and flows back to the heat-exchanger. Then myocardial cooling was induced by the flow of saline at 3.degree.-6.degree. C and a flow rate of 300-400 ml/mln through thts tntraperIcard1 a 1 Irrigation circuit. Myocardial temperatures monitored by the MTS were maintained at 8 to 15.degree. C, although the rectal temperature was kept at over 25.degree. C. The use of cooling coil enabled the duration of aortic cross clomping to prolong up to 3 h. In the control group without the cooling coll, myocardial temperature was quickly elevated and became unstable. Two out of 25 cases in the control group resulted In myocard(a I 1nfarction. The protection of myocard1um was improved by lifting the left ventricle up from the pericardium. irrigating the pericardial cavity through the cooling coll with cold saline and isolating the heart from heat input by draining the blood through the individual cava 1 cannulation and the left atrial vent. under the continuous monitoring of the myocardial temperature by the MTS. Descriptors: HUMAN MYO CARDIAL PROTECTION COLD CARDIOPLEGIA HYPO THE RMIA AORTIC CROSS CLAMPING MYO CARDIAL THERMO SENSOR Concept Codes: BI OP! IYS-GENERAL BIOPHYS TECH( 10504); EXTERN EFF-COLD( 10616): ANATOMY/HISTOL-SURGERY(* 1 1105); PATHOLOGY-TH ERAPY {* 125 1 2 ) ; CARD IOVASC SYST-GENL STUDS.METIIS( 1450i); CARD I 0VASC SYST-HEART PATHOLOGY(*l4506); TEMPERATURE-GENL.MET- HS(*23001); TEMPERATURE-HYPO.HYPERTHERM IA(*2 3006) Biosystemat1c Codes: HOMINIOAE(06215) 75008105 ELECTRICAL CHARGE CONDUCTION MECHANISM DF A POLYMER MEMBRANE ELECTRODE SELECTIVE FOR HYDROPHOBIC CATIONS/w LUCH J R; STERNSON L A; HIGUCHI T DEP. PHARM. CHEM., UNIV. KANS.. LAWRENCE, KANS. 66045. ANAL CHEM 54 (9). 1982. 1583-1588. Coden: ANCHA Language: ENGLISH A plastic electrode Incorporating a polytvlnyl ch1 or Ide )-d1octyIphthaI ate membrane shows Nernstlan response to hydrophobic cations., Magnitude of response Is determined by the thermodynamic activity of the ion and its hydrophobIcIty (l.e., partition coefficient between test solution and membrane phase). Electrodiffusion experiments suggest that the hydrophobic cation Itself is capable of carrying charge and is transmitted through the membrane by its selective solvation by confined negative sites In the form of the carbonyl groups of the plastlclier. diocty1phtha1 ate. Potential development is considered to be localized at membrane-solutIon Interfaces. Concept Codes: BIOCHEM METH-GENERAL(*t0050): BIOCHEM STUD-GENERAL( IOOGO) : BIOPHYS-GENERAL STUDIES( 10502) ; BIOPHYS-- GENERAL BIOPHYS TCH(*10504) R&S 138336 DIALOG F 1 1e5: BIOSIS Previews77-83/Jan BA7502;RRM2402{See Ftle55) (c. BIOSIS 1982) (Item 5 of 858) User 3614 25jan83 1982 75008096 STREAMING POTENTIAL INVESTIGATIONS POLYMER THIN FILMS. VAN WAGENEN R A: COLEMAN D L; KING R N; TRIGLO P; 8R0STR0M L ; SMITH L M; GREGONIS D E; ANDRAOE J D DEP. BI DENG., COLL. ENG., UNIV. UTAH, SALT LAKE CITY, UTAH 8A1 12. J COLLOID INTERFACE SCI JC ISA Language: ENGLISH 84 CD. 1981. 155-162. Coden: Streaming potential evaluations were carried out on a wide variety of bl opo1ymer and synthetic po1ymer thin films supported on glass microscope slides. The film-forming and streaming evaluation techniques are sufficiently accurate to provide reproducible results between different Investigators. Films evaluated to date Include various silanes, albumins, agarose, and synthetic polymers based on hydroxyethyl methacrylate (HEMA), n-butyl methacrylate (n-BMA), and methyl methacrylate (MMA). The effect of negative and positive charge Incorporation upon the streaming potential and thus the .zeta. potential was studied via Incorporation of methacryllc acid (MAA) and both HC1 and CH3CI salts of dImethy 1 am Inoethy 1 methacrylate (OMAEMA) Into the neutral polymer chains of HEMA, n-BMA and MMA via copolymerIzation. Thin films of polystyrene, po1 ydimethy1 slloxane, polyvinyl chloride, and avcothane'were also evaluated successfully. Descriptors: SILANES ALBUMINS AGAROSE HYDROXYETHYL METHACRYLATE N BUTYL METHACRYLATE METHYL METHACRYLATE METHACRYLIC-ACID DI METHYL AMINOE THYL METHACRYLATE POLY STYRENE POLY 01 METHYL SILOXANE POLY VINYL CHLORIDE AVCOTHANE SYNTHETIC BIO MATERIALS Concept Codes: BIOCHEM STUD-GENERAL(10060); 8I0CHEM STUD-PROTEINS,PEPTIDES,AMINO ACD(*10064); BIOCHEM STUO-CARBOH- YDR.(*10068); BIOPHYS-MOLECUL PROP,MACRGMOLECI* 10506); BIOPHYS-BIOENGINEERING(*10511) 75007410 SORPTION DESORPTION OF VINYL CHLORIDE MONOMER IN POLY VINYL CHLORIDE SELECTED FOOD SIMULANTS SYSTEMS, KONTOMINAS M; MILTZ d: GILBERT S G LAB. FOOD CHEM., DEP. CHEM., UNIV. IOANNINA. IOANNINA, GREECE. d FOOD SCI 47 (4). 1982. 1208-1210. Codon: dFDSA Language: ENGLISH Sorpt1on/desorptIon studies of VCM (vinyl chloride monomer] in the systems PVC [polyvinyl chi or Ide]/VCM/water, PVC/VCM/corn oil In PVC/VCM/heptane were carried out. At low VCM concentrations. classical curves are obtained. whore the sorption 1 so t herms are 1 oca ted below their desorption counterparts. Above a certain VCM concentration a crossover exists and an Inversion of the curves occurs. It was suggested that the intersection between the curves represents the point where all the active sites In the polymeric matrix are occupied by monomer molecules. The negative values of the total Gibb's free energy and the energy of mixing In the polymer Increase with the decrease In monomer concentration, point Ino to the ............. .. .... concentrations no migration of VCM Into the contained food from t\ PVC package* may occur. Descriptors: CORN OIL ISOTHERMS FREE ENERGY PACKAGING Concept Codes: MATHEMATIC BIOL/STATISTIC METH(045O0); COMPARATIVE BIOCHEM-GENL STUDIES( 10010); BIOCHEM METH-GENERAL- (10050); BIOCHEM STUO-GENERAL(10060); BIOCHEM STUD-LIPIDS( 10- 066); BIOPHY S-GENERAL STUD IES( 10502); BIOPHYS-GENERAL BIOPHYS TECH( 10504); EXTERN EFF-PHYS I CAL ,'MECH EFFECTS ( 106 1 2 ) ; MOVEMENT!12tOO): FOOD TECH-GENL STUDS.METHS(*13502); FOOD TECH-FATS,0ILS( 135 14 ) ; FOOD TECH-EVALNS PHYS.CHEM PROPS(*1353- 0): FOOD TECH-PREP.PROCESSNG,STORAGE(* 13532); TOXI COL-F00D.RE- SIOS.ADDIT.PRESRV(*22502): PLANT PHYSIOL-CHEM CONST ITUENTS(51522); AGRONOMY-GRAIN CR0PS{52504) B tosystema t1c Codes: GRAMINEAE(253Q5) 1 75007358 DUST CONTENT IN THE WORKING ENVIRONMENT DURING WORK WITH POLY VINYL CHLORIDE. NATOV M; VASILEVA S; SHOPOVA TS HIGH. CHEM.-TECHNOL. INST., SOFIA, BULG. GIG TR PROF ZABOL Coden: GTPZA O (12). 1981 (RECD. 1982). 7-10. Language: RUSSIAN Dust content at various sections of a polyvinyl chloride processing factory was studied. The dust contained mainly 1- to 5-.mu.m particles, and the dust content was highest In sections for preparation and In those for additional mechanical processing of the articles. The effect of humidity and temperature on the dust content In the air of workplaces and Its effects on workers were studied. Polyvinyl chloride dust content decreased In higher humidity and Increased at higher temperatures. Descriptors: HUMAN HUMIDITY HEAT Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM-GASES(10012); BIOCHEM STUD-GENERAL(10060); EXTERN EFF-HOT(* 10618); EXTERN EFF-HUMIDITV(*10620>: PATHOLOGY-GENER- AL 5TUDIES( 12502); METABOLISM-GENL STUD.METAB PATHW{ 1 3002): TOXICDL-ENVIRONMNTL,INDUSTR(22506); ENVIRON HE ALTH-GCCUPATNL HEAL7H(*37013); ENVI RON HEALTH-A IR.WATR,SL POLLN{* 37015 ) 8losystema t1c Codes: IIGMINIDAE(86215) D IALO R&S 138337 BIOSIS Prav t ews 77-B3/Uan BA7502;RRM2402(See Flie55) (c. BIOSIS 1982) (Item 8 of 858) User 3614 25Jan83 1983 75007355 AOIPOGENIC EFFECT OF SOME INDUSTRIAL POISONS. MAKAROV I A: MAKARENKO K I; DE5YATNIKOVA N V INST. INO. MYG. OCCUP. DIS., GORKI, USSR. GIG TR PROF ZABOL 0 (12). 19B1 (RECD. 1982). 29-32. Coden: GTPZA Language: RUSS I AN ' Anthropometric examinations were performed on 676 workers exposed to methyl methacrylate (MMA), 700 workers engaged In the manufacture of vinyl chloride (VC) and 512 mechanics. The basal Insulin level was examined In 119 subjects, somatotropic hormone [STH] level In 123 and prolactin level In 86. MMA and VC produced adlpogentc action. The adlpogenic effect of VC was more pronounced and was observed In males and females; MAA affected only women. Adlpopexlc disturbances In workers engaged In chemical Industry were due to development of toxlcogenlc hormonal imbalance; Increased Insul In and prolactin secretion In the presence of Inhibited STH product 1 on. Descriptors; HUMAN MECHANIC METHYL METHACRYLATE VINYL CHLORIDE INSULIN PROLACTIN SOMATOTROPIC HORMONE SEX DIFFERENCE Concept Codes: GENETICS/CYTOGENET-SEX DIFFERENC(035 to); SOCIAL BIOL/HtJMAN ECOLOGY(05500); CLIN BIOCHEM-GENL STUDIES(* 10006); BIOCHEM STUD-PROT INS.PEPTIDES.AMI NO ACD(IOO- 64); BIOCHEM STUD-LIPI0S(10066); BIOCHEM STUD-STEROLS.STEROID- S(10067); PATHOLOGY-COMPARATIVE(12503); ME T ABOU SM-L IP1 DS (*13- OOG) ;. MF. T ABOU SM-STEROLS. STEROIDS{ 1300Q) ; METABOUSM-PROTNS.P- EPIDS,AM ACDS{* 13012); ENDOCRINE SYST-PANCREAS(*17008); ENDOCRINE SYST-PI TUITARY(* 17014); BONE,JNTS,FASC.CONN/AD IP-PA THOL < *18006); T0X1CDL-ENVIRONMNTL.INOUSTR(* 22506); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-AIR,WATR.SL POLLN(*37015) BIosysteraat1c Codes: HOMINIOAE{86215) O1 > : nACTERlOLOr.Y-GENL . TAXONOM STUDS (* 30000 > ; ENVIRON HEALTH-SEWG DISP,SANITAH<37014): ENVIRON HEALTH-A 1R,WATR,SL POLLN{*37015); FOOO/INDUS MICRO-BIOOEGRAO.DETER(*33006) Blosystema t1c Codes: MI CR00RGAN1 SMS-UNSPEC1 F I ED ( 0 100(3 ) ; ACTINOMYCETES AND RELATED ORGANISMS-UNSPECIFIE(05800): NOCARD IACEAE(05824 ); STREPTOMYCETACEAE(05828 ) 24006041 MECHANISTIC ASPECTS OF THE THERMAL FORMATION OF HALOGENATED ORGANIC COMPOUNDS INCLUDING POLY CHLORINATED DI BENZO-P-DIOXINS 3. THERMO DEGRADATION OF ORGANO METALLICS AND POLYMERS. CHOUDHRY G G; HUTZINGER O LAB. ENVIRON. TOXICOL. CHEM.. UNIV. AMSTERDAM. ACHTERGRACHT 166. 1018 WV AMSTERDAM. NETH. NIEUWE TOXICOL ENVIRON CHEM Language: ENGLISH 5 (2). 1982. 97-152. Coden: TECSD Descriptors: POLY VINYL CHLORIDE BENZENE HYDRO CHLORIC-ACID Concept Codes: BIOCHEM METH-GENERAL(10050); BIOCHEM METK-MINERALS( 10059); BIOCHEM STUD-GENERAL(*10060); MINERALS(- *10069); BIOPHYS-GENERAL BIOPHYS TECH( 10504); EXTERN EFF-HOTt10618); TOXI COL-GENL/EXP STUDS.METHS(2250 1 } ; TOXICOL- -ENVIRONMNTL.INDUSTR(*22506) 75006527 OCCURRENCE AND SIGNIFICANCE OF ACTINOMYCETES IN DRINKING WATER. OOTT W; WASCHKO-DRANSMANN D HYGIENE-INST. DER UNIV. BONN, XLINIKGELAENDE 35, 0-5300 BONN 1. ZENTRALBL BAKTER10L MIKR08I0L HYG ABT l ORIG B MYG UMWELTHYG KRANKENHAUSHYG ARBEITSHYG PRAEV MED 173 {3-4)* 1981. 217-232. Coden: ZAOMD Language: GERMAN Different act 1 nomycetes were found In raw water depending on the origin of the water. The water treatment process Influenced the total count and the species distribution. Act1nomycetes were also Isolated from the slime formed by microbial growth on polyvinyl chlorlde-C coated walls In reservoirs. The typical earthy-musty odor was produced only by Streptomyces; some Nocardla Isolates produced a phenolic odor. Descriptors: MICROBIAL SLIME STREPTOMYCES NOCAROIA RAW WATER WATER TREATMENT PROCESS POLY VINYL CHLORIDE COATEO RESERVOIR WALL EARTHY MUSTY ODOR PHENOLIC ODOR Concept Codes:. ECOLOGY-LIMNOLOGY ( *075 14 ) : ECOLOGY - WATR RESRCH,FISHERY BI0L(07517); SENSE ORGANS -GENL STUOS.METHS(200- R&S 138338 DIAL0G^me5: 8I0SIS Previews 77-83/Jan BA7502 : RRM2402 (See File55) (c. BIOSIS 1982) (Item 11 of 858) User 3614 25Jan83 1984 7 A082380 CHEMICAL CONTROL OF THE PINE GALL MIDGES THECODIPLQSIS-JAPONENSIS 4, IMPROVEMENT OF THE TRUNK IMPLANTATION METHODS OF INSECTICIDES. CHOI S Y; LEE H R; AHN Y J COLL. OF AGRICULTURE. SEOUL NATIONAL UNIV., SUWEON, KOREA. SEOUL NATL UNIV COLL AGRIC BULL 6 (2). 1981 (RECD. 1982). 21-32. Coden: NYSTO Language: KOREAN A series of experiments were conducted to evaluate Insecticides for control of the pine gall midge (T. Japonensls Uchlda et Inouye) and to find more feasible and efficient [Insecticide] trunk-Imp 1 antatIon methods than the conventional dr 11 I - Imp!anta11 on method. Insecticides tested were emulsion concentrates Follmat (omethoate. Ec {emu 1s1f1ab1e concentrate] 50%) . Kttval (vam1doth 1 on, Ec 40%), Dlmecron (phosphamIdon, Ec 50/.), Metasystox-R (oxydemeton-me thy! , . Ec 40%) and Sallthlon (24% Ec). Insecticides were Implanted Into the tree trunk using 3 different methods; method (A) was the Mauget Injector Unit, method (B) employs a PVC-tube [polyvinyl chloride] and method (C) used the conventional drill. With method A. Follmat was very effective for suppressing gall incidence by the Insects, followed by (Kflval) and Dlmecron. Implantation of Follmat using method B was most effective In suppression of gall Incidence followed by Kllval. Dlmecron and Motasystox Sallthlon was Ineffective. Method C results were similar to that of method B. The order of control effectiveness among the methods tested in terms of gall Incidence was method C > B > A. The number of larvae In the gall were relatively lower In the plots treated with Follmat by methods B and C. Recovery of holes bored for Implanting Insecticides were good In methods A and B, while most of the holes drilled by method C were not recovered until Oct. 31. Method 8 using the PVC-tube, was considered the most feasible and efficient method. Descriptors: GALL INCIDENCE FDI.IMAT KILVAL DIMECRON METASYSTOX R SAL ITHION MAUGET INJECTOR UNIT POLY VINYL CHLORIDE TUBING DRILLING Concept Codes: GENERAL FIELD METHODSfO1008); GENERAL FIELD APPARATUS(OIOIO); BIOCHEM STUD-GENERAL{10060); EXTERN EFF-PHY5ICAL,MECH EFFECTS(10612): TOXICGL-GENL/EXP STUDS.METH- S(*22501); FORESTRY AND FOREST PRODUCTS{*53500): PHYTOPATHOL-DIS BY ANIM PARASITE(*54508); PEST CONTRL GENL/PESTICS/HERB ICS(*54600); ECONOM ENTOMOL-TREE.ORN.WD PRODSf*60010); ECONOM ENTOMOL-CHEM PHYS CONTRL[*60016); INVERTS PHYSIOL-INSECTA-PATHOLf*64078) B1osysterna t1c Codes: SPERMATOPHYTA-UNSPECIFIE0(25000): 0IPTERAC75314); ABSTRACTS OF ENTOMOLOGY(96000) . grade poly(v1nyl chloride) was Implanted In rat gluteal muscle and muscle specimens taken from the Implanted and non-1mp1 anted sites after 7, 14 and 21 days. In the muscle homogenate taken (n suitable solvents, the activities of alkaline phosphatase, acid phosphatase. Ca2+ ATPase. leucine am 1 nopop11dase (LAP) and succinic dehydrogenase (SDH) were tested and compared at Implanted and nonlmplanted sites. Increased activity of acid phosphatase. alkaline phosphatase, LAP and Ca2 + ATPase were seen at the implanted site but the SDH activity was reduced. The enzyme activity at both sites' was maximum around 14 days and the highest Increase in activity at the Implant site compared to the control site was observed for alkaline phosphatase and acid phosphatase. After 21 days, the activity decreased graduaI 1y. In the case of SDH, the Inhibition was more after 14 days and gradually decreased after 21 days. Descriptors: RAT MUSCLE ALKALINE PHOSPHATASE ACID PHOSPHATASE CALCIUM ATPASE LEUCINE AMINO PEPTIDASE SUCCINIC DEHYDROGENASE Concept Codes: BIOCHEM STUD-GENERAL(* 10060) ; BIOCHEM STUO-PROTEINS.PEPTIDES.AMINO ACD( 10064); BIOPHYS-BIOENGINEERI- NG(* 105 11); ENZYME S-PHYSIOLOGI CAL STUD IES( * 10808) ; S Y S T- PHY SI 0 L.BIOCHEM( 17 504} MUSCLE B losystematIc Codes: MUR I DAE(86375 ) 74080758 BIO COMPATIBILITY SCREENING OF POLY VINYL CHLDRIDE IMPLANTS. SHARMA R; VASUDEVAN P INDIANA INST. TECHNOL., NEW DELHI 110. 016, INDIA. BIOMATERIALS 3 (2). 1982. 109-112. Codon: BIMAD Language: ENGL ISH The b1ocompat1b111ty of a polymeric Implant was tested by assaying enzyme activity in the tissue homogenate. Medical R&S 138339 DIALOG F11e5: BIOSIS Previews 77-83/Jan BA7502:RRM2402(See F1)e55) (c. BIOSIS 1982) (Item 13 of 858) User 36)4 25Jan83 1965 74079966 COMPARATIVE TOXICOLOGICAL BURNING OF MULTI COMPONENTIAL SYNTHETIC FIBERS. ASSESSMENT OF PRODUCTS FROM MATERIALS BASED ON WOOL AND E1T1NG0N A I; P00DU8NAYA L T; SHASHINA T A; NAUMOVA L S INST . IND. HYG. OCCUP. DIS., ACAD. MED. SCI. USSR. MOSCOW. USSR. GIG TR PROF ZABOL Language: RUSSIAN 0 (9). 1981. 50-52. Codon: GTPZA The effect of adding wool to synthetic fibers (kapron, acetoch!or 1ne, lavsan, polyvinyl chloride) on the toxicity of products from burning multIcomponent1 a 1 materials was studied. Experimental mice were subjected to 5 min of toxic effect In a chamber containing products from burning material. The toxic effect was assessed by death of mice and was expressed In weight of material relative to the volume of the chamber necessary for Inducing LD50. Chemical and analytical studies revealed that kapron emitted 47.6 mg HCN and 25 mg CO during burning and wool emitted 8.5 mg HCN and 46.9 CO. The other 3 synthetic materials did not 'emit HCN In burning. Knowing the Individual fiber toxicity. It was supposed that toxicity of mu 111 component 1 a 1 materials would correspond to the added toxicity of Individual fibers In direct proportion to their content percentage. Experimenta1ly determined toxicity parameters for mixed materials (19.5-32.0 mg HCN) were considerably lower than calculated ones. CO emission from mixed fiber materials differed tittle from those of pure wool. The Intensified HCN effect could be due to the combined effect of products from burning N-contalnlng (wool and kapron) and Cl-contaInlng (acetochlorine and polyvinyl chloride) materials, or It could be due to changes of the mechanism and quantity of emission of the highest toxic components from burning of mixed materials. Descriptors: MOUSE KAPRON ACETO CHLORINE LAVSAN POLY-VINYL CHLORIDE LD-50 HYDROGEN CYANIDE CARBON MON OXIDE Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500); BIOCHEM-GASESt10012); BIOCHEM STUD-GENERAL(10060); BIOPHYS-BI- OCYBERNETICS(10515); PATHOLOGY-GENERAL STUD IES( 12502); PATHOLOGY-COMPARATIVE(12503); PATHOLOGY-NECROSIS(t2510); META- BOLISM-GENL STUD , METAB PATHW( 13002): TOXICOL-GENL/EXP STUDS,METHS(*22501); TOXICOL-ENVIRONMNTL,INDUSTR(22506) Blosystematic Codes: MURIDAE(86375) 74073968 AN EXAMINATION OF THE PHYSICAL CHARACTERISTICS LEADING TO ANGIO PLASTY BALLOON RUPTURE. GERLOCK A J JR; REGEN D M: SHAFF M I VANDERBILT UNIV. SCH. MED., DEP. RADIOL., 2 1ST GARLAND AVE. . NASHVILLE', TN 37232. RADIOLOGY ' 144 (2). 1982. 421-422. Coden: RADLA Language: ENGLISH Six polyvinyl chloride and 6 polyethylene angloplastly ba11oons were Inflated 6 times each under 1abora tory conditions. Outside diameter of the balloons was measured on Initial and final Inflations; volume was measured by water dl?;plAr:frncin* ^ t i nf H + 'nr THrmn ^ ~ 1 * J ' - were constricted with a silk suture around the midportion. Balloons were then Intentionally ruptured and the rupture site recorded. The diameters of the polyvinyl chloride balloons increased over 6'Inflattons, while they remained relatively constant for the polyethylene balloons. Rupture sites were In the area of the balloon that had the greatest outside diameter and the tears were 1ongItud1nat. Descriptors: POLY VINYL CHLORIDE POLY ETHYLENE Concept Codes: BIOCHEM STUD-GENERAL(10060); EXTERN EFF-PHYSICAL,MECH EFFECTS(* 106 1 2 ) ; ANATOMY/HISTOL-EXPER1MENTA- L(*11104); PAT HOLOGY-THERAPY( 125 12) ; CARDIOVASC SY ST-GENL STUDS,METHS( 1450 1 ); CARDIOVASC SYST-BLD VESS PATHOL(* 14508) BIosys tema t1c Codes: VERTE8RATA-UNSPECIFI ED(85150) 74073479 PREPARATION AND ELECTRON SPECTROSCOPY FOR CHEMICAL ANALYSIS CHARACTERIZATION OF POLY VINYL CHLORIDE SURFACE GRAFTED WITH HEPARIN COMPLEXING POLY AMIDO AMINE CHAINS. FERRUTI P; BARBUCCI R; OANZO N-. TORRISI A; PUGLISI 0; PIGNATARO S: SPARTANO P 1ST. CHIMICA 1NTERMEDI. VIA RISORGIMENTO 4. 40186 BOLOGNA. ITALY. ` BIOMATERIALS 3 (l). 1982. 33-37. Coden: BIMAD Language: ENGLISH By a simple process po1y(am 1do-am1ne) chains were grafted on the surface of poly (vinyl chloride). Grafted poly(viny1 chloride) Is able to adsorb heparin, providing potentially nontlirombogen1c surfaces. The grafting of po1y(am 1 do-am Ine) and the heparin adsorption were studied by ESCA (electron spectroscopy for chemleal analysis). The total amount of grafted po1y{amIdo-am1ne) depends on the MW of the po1ytam 1 do-amtne) used In the grafting reaction. but the amount of heparIn adsorbed on the grafted material Is relatively Independent of the length of the po1y(am 1do-am1ne)-graf ted chaIns. DescrIptors: ANTICOAGULANT PHARMACEUTICAL -ADJUNCT Concept Codes: GENERAL LABORATORY METH0DS(O1004); BIOCHEM METH-GENERAL(10050); BIOCHEM METH-CARBOHYDRATES(10058); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-CARBOHYDR.(10068); BIOPHYS-GENERAL BI0PHY5 TECH(10504); BIOPHYS-MOLECUL PROP,MACROMOLECt10506): BIOPHYS-BIOENGINEERING{10511); ANATO MY/HI STOL-REGEN.TRANSPLANT(*11107); PHARMACOL-BLOOO,HEMATO AGENTS{*22008) R&S 138340 DIALOG FHe5: BIOSIS Prev I ews. 77-83/dan BA7502 ; RRM2402 ( See FUe55) (c. BIOSIS 1982) (Item 16 of 858) User 3614 25Jan83 1986 74058896 THE INFLUENCE OF HEPARINIZED POLYMERS ON THE RETENTION OF PLATELETS AGGREGABILITY DURING STORAGE. MORI Y; NAGAOKA S; KIKUCHI T; TANZAWA H BASIC RESEARCH LABORATORY. TORAY INDUSTRIES. INC., KAMAKURA 24 B, UPN. vJ BIOMED MATER RES 16 (3). 1982. 209-218. Coden: JBMRB Language: ENGL ISH The change 1n aggregab1 1 f ty of the platelets stored In the storage tube fabricated from a newly developed heparinized hydroph11 1c po1ymer (H-RSO) was stud led In comparIson with plasticized polyvinyl chloride (PVC) which Is widely used for blood bags. Rabbit blood was directly withdrawn from the carotid Into the storage tube containing an anticoagulant. Then the tube was mechanically sealed with screw cocfcs and centrifugated to prepare p1 ate1et-r1ch plasma {PRP} In the tube and again mechanically clamped to separate the PRP from the residual precipitate. The PRP was stored In situ In the storage tubB at room temperature under agitation. During storage, the change In the aggregabI 1 Ity of the PRP Induced by ADP was studied and the morphological change In the platelets adhered onto the Inner surface of the storage tube was observed by scanning electron microscopy. In the H-RSD tube, the aggregab1l1ty was completely lost after 1-day storage. The scanning electron microscopic studies demonstrated that the reduction In the aggregab11 tty of the stored platelets Is closely correlated with the morphological deformation of the platelets adhered onto the surface of the storage tube. Descriptors: RABBIT ANTICOAGULANT POLY VINYL CHLORIDE BLOOD RAGS ADP Concept -Codes: GENERAL LABORATORY METHOOS(01004}; GENERAL LABORATORY APPARATUS(01006): ' MICROSCOPY-CYTOLOG.CYTOCHEM 7ECH( 01054 ) MICROSCOP Y - HI STOL . HI STOCHEM TECH(01056 ) ; ELECTRON MICROSCOPY(O1058): CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD.PURNS.PYRM(10062): BIOCHEM STUO-CARBOHYDR.(10068): BIOPHYS-GENERAL BIOPHYS TECH{10504); EXTERN EFF-TEMPERATURE(10614); ANATOMY/HISTOL-MI CRO ,ULTRAMICRSC{11108); BLOOD/BOOY FLDS-GENL STUDS.METHS(* 150- 01); BLD0D/80DY FLDS-BLOOO CELL STUOS(* 15004); 8L000/B00Y FLDS-LYMPHAT TISS.RES( 15008); PHARMACOL-BLOOD.HEMATO AGENTS { - *22008); TEMPERATURE-GENL.METHS(23001) BiosystematIc Codes: LEPORIDAE(86040) Language: ENGLISH Human red blood cell concentrates drown from normal healthy volunteers with hematocrits of 85 .+-. 5 V % wore stored In the CPDA-1 [citrate, phosphate, dextrose, aden1ne], CPOA-2 or CPDA-3 anticoagulant at 4.degree. C for 35 days. After liquid storage. the red blood cel 1 concentrates wore biochemical ly treated with 50 ml of a solution containing tOO mM/1 pyruvate. 1O0 mM/1 1 nosine, 100 mM/t phosphate and 5 mM/1 adenine (PIPA, solution C), to increase their 2.3 DPG [dIphosphog1ycerate ] and ATP levels which had deteriorated during storage at 4.degree. C. The rejuvenated red blood cells were frozen with 40% wt/vol glycerol in the polyvinyl chloride plastic primary collection bag and were stored at -BO.degree. C for up to 3 mo. After thawing, the red blood cells were washed with 50 ml of 12% NaCl and 1.5 to 1.6 l of 0.9% NaCl. 0.2% glucose and 25 meq[equ1va1ent]/1 dlsodlum phosphate. The washed red blood cells were stored at 4.degree. C for 24 h prior to autologous transfusion. The CPDA-1 -stored red blood cells had a 24 h post-transfusion survival of 82 .+-. 7% (n * 6). and the index of therapeutic effectiveness (ITE) was 75 .+-. 7% (n * 6). The CPDA-2-stored red blood cells had a survival of 85 .+-. 2% (n * 3). with an ITE of 79 .+-. 1%. The survival of the CPDA-3-stored red blood cells was 90 . + 3% (n * 4) and the ITE was 84 4%. All units had Improved 02 delivery capacity, with 2,3 DPG and ATP levels of about 150% of normal after thawing and storage at 4.degree. C for 24 h. Red btood cell concentrates with hematocrit values of 85 .+-. 5% can be stores effectively In CPDA-1, COPA-2 or CPDA-3 at 4.degree. C for 35 days, biochemically modified, freeze-preserved with 40% wt/vol glycerol In the polyvinyl chloride plastic primary collection bog at -80.degree. C. and stored after washing for 24 h at 4,degree. C before transfusion. Descriptors: ATP 2 3 01 PHOSPHO GLYCERATE POST TRANSFUSION SURVIVAL OXYGEN DELIVERY CAPACITY Concept CodC3 : MI CROSCOPY-CY T01.0G , CYTOCHEM TECHf0 1054); CYTOLOGY/CYTOCHEM-HUMAN(*02508): BIOCHEM-GASES{10012): BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURNS.PYRM(10062); BIOCHEM STUD-CARBOHYDR.(10068); MINERALS(10069); EXTERN EFF-C0LD(10616); METABOLISM-ENERGY.RESP1RATION(13003): METAB OLISM-CARBOHYDRATES ( 1 3004 ) ; MINERALS(*13010): METABOLISM-NUCL ACD,PURINS.PYRIM(* 13014); BLOOO/BODY FLDS-GENL STUDS.METHS{ 15 - 001): 8L0DD/B0DY FLDS-BLOOD.LYMPH STUD(* 15002); BLOOD/BODY FLDS-BLOOD CELL STUDS(* 15004); TEMPERATURE-CRYOB I 0LOGY(* 23004 ) Blosys tema tic Codes: HOM1NI DAE(86215) 74058790 RED BLOOD CELL CONCENTRATES STORED AT 4 CELSIUS FOR 35 DAYS IN CITRATE PHOSPHATE DEXTROSE ADENINE "1 CITRATE PHOSPHATE DEXTROSE AOENINE 2 OR CITRATE PHOSPHATE DEXTROSE ADENINE 3 ANTI COAGULANT PRESERVATIVE BIOCHEMICALLY MODIFIED AND FROZEN AND STORED IN THE POLY VINYL CHLORIDE PLASTIC PRIMARY COLLECTION BAG WITH 40 PERCENT WEIGHT VOLUME GLYCEROL AT MINUS 80 CELSIUS. VALERI C R; VALERI D A; GRAY A; MELARAGNO A; DENNIS R C; EMERSON C P NAVAL BLOOD RESEARCH LAB., BOSTON UNIV. SCH. MED.. 615 ALBANY ST.. BOSTON, MA. 02118. ic x om fnurtAl > * oon i ry > _ IOC DIALQG e5 : 8I0SIS Previews 77-B3. R&S 138341 ,,,,.jux;KKM2402(See Fi)e55) (c . BIOSIS 1982) (Item 18 of 058) User 3614 25jan83 1987 74057987 IDENTIFICATION BY GAS CHROMATOGRAPHY MASS SPECTROMETRY OF VINYL CHLORIDE OLIGOMERS AND OTHER LOW MOLECULAR WEIGHT COMPONENTS IN POLY VINYL CHLORIDE RESINS FOR FOOD PACKAGING APPLICATIONS/x GILBERT O; SHEPHERD M J; STARTIN J R; WALLWORK M A MINISTRY AGRIC.. FISHERIES. FOOD. FOOO SCI. OIV.. HALDIN HOUSE. QUEEN ST., NORWICH NR2 4SX, GREAT BRITAIN. U CHROMATOGR 237 (2). 1982. 249-262. Coden: dOCRA Language: ENGLISH Material of MW < .apprx. 400-500 was Isolated from food grade polytvlnyl chloride) resins by Initial soxhlet diethyl ether extraction and subsequent s1te-exc1 us Ion fractionation. Analysts by packed-column gas chroma tography using Hall electrolytic conductivity detection showed the presence of a series of chlorinated components which by subsequent gas chroma tography-mass spectrometry were tentatively tdent(fled as vinyl chloride oligomers. The chlorinated constituents In the extracts were selectively Isolated from other low MW components by silica gel chromatography. From low-resolution capillary gas chromatography-mass spectrometry data (together with evidence from hydrogenated extracts) the structures of these oligomers were postulated as being a complete series ranging from trlmer to hex^mer (and probably to the octamcr), each oligomer being represented by species containing a ring or a double bond and each occurring as a number of structural Isomers. Other nonch1 or 1nated compounds Identified In the resins Included mixed phthalates. alkanes, nonylphenol and undecyl dodecanoate. the latter being derived from the polymerIzatlon Initiator 1aury1 peroxide. Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES(10010) : BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUD-GENERAL(10060); 8IOPHYS-GENERAL BIOPHYS TECH(10504); MOVEMENT(121O0); NUTRITION-MALNUTRITION.OBESITY(13203); NUTRITION-PATHOGENIC OIETSt 13216) ; FOOD TECH-GENL STUDS,METHS(* 13502); FOOD TECH-EVALNS PHYS.CHEM PROPS(13530); FOOD TECH-PREP.PROCESSNG,- STORAGE(* 13532 ) : TOXICOL-FOOD,RES IDS.ADD IT.PRESRVt *22502) 74057904 BIOLOGICAL EFFECT OF AEROSOLS MADE FROM POLY VINYL CHLORIDE AND EPOXY PLASTICS. SI1AKSIBAZYAN G KH; SHEVCHENKO A M; GONCHARUK G A; PUSHKAR M P ; YAVOROVSKY A P A. A. BOGOMOLETS KIEV MED. INST.. KIEV. USSR. VESTN AKAD MED NAUK SSSR 0 (1). 1981. 58-62. Coden: VAMNA Language: RUSSIAN Comprehensive 1ndustria 1-hyg1en1c, c11n1ca1 -stat1st1ca1 and experimental studies (rats, mice] Identified the main occupational hazards In the manufacture of polyvinyl chloride and epoxy plastics. The pat tern and rate of morb1dIty depended on the working conditions. Composite (vapor-gas-a'eroso 1 ) mixtures occurring during the manufacture and processing of these plastics may produce sens!t1z 1 ng. ft brogen1c. embryotoxic and, gonadotoxlc effects along with general toxic and Irritative ones. The need for developing and applying a sot of measures to prevent the adverse! effects of polyvinyl chloride and epoxy formulations on the health of workers was shown. Descriptors: HUMAN RAT MOUSE GONADO TOXICITY EMBRYO TOXICITY FIBROSIS ALLERGY OCCUPATIONAL HEALTH Concept Codes: BIOCHEM-GASES(1O012); BIOCHEM STUD-GENERAL( 1 - 0060): BIOCHEM STUD -PROTEI NS,PEPTIDES.AMINO ACD( 100G4) ; PATHOLOGY-GENERAL STUD IES( 1 2502); PATHOLOGY-COMPARATIVE( 12503) ; METABOLISM-GENL STUD,METAB PATHW(13002); METABOLISM-PROTNS,- PEPTDS.AM ACDS(* 13012); REPRODUCT SYST-PATHOLOGY( 16506) ; BONE.UNTS,FASC,CDNN/ADIP-PATHOL(* 18006); TOXICOL-ANTIDOTES.PREVENT IVE(*22505); TOXICOL -ENVIRONMNT L. INDUSTR(* 22506); DEVELOP MN T L BIOL-PATHOLO- GICAL(*25503): DEVELOPMNTL BIOL-EXPERIMENTAL(*25504); DEVELOPMNTL BIOL-GEN MORPHGENSIS(* 25508); IMMUNOL/IMMUNOCHEM-IMMUNOP- ATHOL(*34508); ALLERGY(*35500); ENVIRON HEALTH-OCCUPATNL HEALTHt*37013); ENVI RON HEALTH-A IR.WATR,SL POLLN(*37015) B losystemat1c Codes; HOMINIOAE(86215); MURIDAE(86375); BIOSIS INTERNAL USE(97100) 74056101 PROCEDURE FOR STUDYING THE STRENGTH OF MICRO CAPSULAR ENVELOPES DURING EMULSIFICATION. BABAK V G; ZIMON A D; NEVEROVA E A; CHLENOV V A ALL-UNION CORRESP. INST. FOOD INST., MOSCOW. USSR KHIM-FARM ZH 15 (4). 1981. 110-112. Coden; KHFZA Language: RUSSIAN A procedure was developed for studying the strength of polymer adsorption layers at various Interphaslc edges under condIt1ons of contact Interactions. The resls tance of H20 film stabilized by polyvinyl `chloride (PVC) adsorption layers during contact of hydrophobic phases (solid and liquid) was studied in relation to PVC concentration In solution and length of adsorp tion layer aging. This procedure can be used for determining optimal polymer concentration In solution which Is essential for stabilizing emulsions or suspensions of m1crocapsu1 a ted drugs. Descriptors; POLY VINYL CHLORIDE PHARMACEUTICAL-ADJUNCT MICRO ENCAPSULATED DRUGS Concept Codes: BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUD-GENERAL(10060): BIOPHYS-GENERAL BIOPHYS TECH{10504); BIOPHYS-MOL E CIJL PROP.MACROMOLEC( 10506}; PHARMACOL - GENERAL STUD IES(2 2002) R&S 138342 DIALOG F It e5 r BIOSIS Previews. 77-83/Jan 8A7502;RRM2402(See Flle55) (c. BIOSIS 1982) (Item 21 of 858) User 3614 25Jan83 1988 74050769 INCREASED ACETONE EXHALATION INDUCED BY METABOLITES OF HALOGENATED 1 CARBON AND 2 CARBON COMPOUNDS. FILSER J G; JUNG P; BOLT H M ABTEI LUNG TOXIKOL., PHARMACKOLGISCHES INST. ZAHLBACHER STR. 67, 0-6500 MAINZ 1, FRG. UNIV. OBERE ARCH TOXICOL 49 (2). 1982. Language: ENGLISH 107-116. Coden: ARTOO Rats were exposed, in a closed desiccator Jar chamber, to concentrat Ions of various halogenated Cl and C2 compounds at which the metabolizing capac fties were saturated (Vmax conditions). Within the exposure period of 50 h concentrations of the xenoblotic and of exhaled acetone were monitored In the gas phase of the system. The quantitative extent of acetone exhalation was dependent on the Individual compound examined. Acetone exhalation was stimulated in the presence of vinyl chloride, vinyl bromide, vinyl fluoride, vinylIdene fluoride, els- and trans-l,2-dlchloroethylene, trichloroethylene, perch 1oroethyIene. methylene chloride, chloroform, CC14 and 1,1,2-trIchloroethane. No stimulation of acetone exhalation occurred with I. I, 1 -1rIch)oroethane and with the reference hydrocarbon n-liexane. Acetone exhalation was evoked by Infusions of fluoroacetate or chioroaceta to, 2 anticipated or proven metabolites of some ha 1oethy1enes; the Infusion rates of which wore based on calculations of the metabolic rates of vinylidene fluoride and of vinyl chloride, respectively. Descriptors: RAT Concept Codes: BIOCHEM-GASESt10012); BIOCHEM STUD-GENERAL(1 - 0060);' PATHOLOGY-GENERAL STUD IES( 12502 ) ; PATHOLOGY-COMPARATIV- E{ 12503); METABOLISM-GENL STUD,METAB PATHWC 1 3002); RESPIRATORY SYST-GENL STUD , METHSf16001); RESPIRATORY SYST-PATHOLOGY(*1600- 6); ROUTES OF IMMUNIZ,INFECT,THERAP(22iOO); TOXICOL-GENL/EXP STUDS.METHSi`22501) Biosysternat1c Codes: MURIOAE(86375) TOXI COL -ENVIRONMNTL, INDUSTR( `22506); ENVIRON HEALTH-OCCUPATNL HEALTHC*370 13); ENVIRON HEALTH-AIR,WATR,SL P0LLN{* 370 15) BlosystomatIc Codes: HOMINIDAE{862 15) 74050661 EXTERNAL RESPIRATION FEATURES OF WORKERS IN POLY VINYL CHLORIDE PRODUCTION BY THE LATEX METHOD. GLUSHKO L V; NEIKO E M; BABENKO N A DIV. FAC. THER.. IVANO-FRANKOVSK. USSR. IVANO-FRANKOVSK MED. INST.. VRACH DEIO 0 (4). 1981. 35-36. Codon: VROEA Language: RUSSIAN A splrographtc study of external respiration In 13B male and 88 fnmale polyvinylchloride produc11 on workers by the latex method indicated no ventilation disorders of tho restructIve and obstructive character. The dtffusory membranes of the lungs wore In good condition. The high level of oxidation was provided by an adequate strengthening of the external respiration apparatus. Descriptors: HUMAN Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD-GENERAL(10060); 01OPHYS- MEMBRANE PHENOMENAC 10508): 81DPI IYS-BIOENERGETICS( 105 10): PATHOLOGY-01 AGNOSTIC(* 12504 ): METABOLISM-GENL STUO,METAB PATHW( 1 3002); RESPIRATORY SYST-GENL R&S 138343 DIALOG FUe5: 8I0SIS Previews 77-83/Jan BA7502:RRM2402(See flle55) (c. BIOSIS 1982) (Item 23 of 858) User 3614 25Jan83 1989 74047851 VINYL CHLORIDE INDUCED HEPATIC LESIONS IN MAN ANO RODENTS A COMPARISON. POPPER H; MALTQNI C; SELIKOFF I 0 STRATTON LAB. FOR THE STUDY OF LIVER DISEASE. MOUNT SINAI SCH. OF MEO. OF THE CITY UNIV. OF NEW YORK, NY. LIVER 1 (1). 1981. 7-20. Coden: LIVED Language: ENGLISH Histologic sequences in the liver of rodents exposed by 1nha1 at 1 on to gaseous vinyl chloride were compared to the lesions In man exposed to the same agent, mainly In vinyl chloride polymerization plants. An Identical sequence, starting with circumscribed proliferation of hepatocytes, soon followed by proliferation of a variety of sinusoidal celts and frequently associated with sinusoidal dilatation, progresses to 1nt rn1obular and more frequently to trabecular ang1 osarcoma. Predam 1nant1y In young animats and rarely In man, hepatocellular carcinoma develops but never cirrhosis. The sequence represents a dynamic process of competition between proliferating hepatocytes and sinusoidal cells, of hepatocytes with fibroplasia, between per 1s1nusoIda 1 fibrosis and sinusoidal dilatation and of proliferation of various sinusoidal cells vs. angiosarcoma. The great similarity In the evolution In man and rodents, rarely encountered In other experimental models. supports the prediction of human cancer from animal experiments. The precursor nodules differ from the nodules commonly observed In hepatocarc1 nogenes 1s by copro1 Iferat1 on of sinusoidal cells. The differences In the reactions between man and rodents bespeak a strong fibroblastic reactivity In man. Most Important, the precursor lesion of mixed hepatocellular and sinusoidal cell prol1feration may be of diagnostic value. being superior to convent 1ona1 hepa tic tests In detection of some Initial environmental lesions. Descriptors: POLYMERIZATION PLANTS HEPATOCYTE SINUSOIDAL CELL CARCINOGEN TRABECULAR ANGIO SARCOMA HEPATO CELLULAR CARCINOMA FIBROPLASIA PERI SINUSOIDAL FIBROSIS SINUSOIDAL DILATATION HISTOLOGY PROLIFERATION Concept Codes: MICROSCOPY-HISTOL,HISTOCHEM TECH(Ot056); CYTOLOGY/CYTOCHEM-ANIMAL(02506); CYTOLOGY/CYTOCHEM-HUMAN(02508); BIOCHEM STUD-GENERALt10060): ANATOMY/HISTOL-MICRO,ULTRAMICRSCft1108); PA THOLOGY-COMPARATIVE{12503); PATHOLOGY-0 IAGNOSTIC( 12504); DIGESTIVE SYST-ANATOMY(14002); OIGESTIVE SYST-PATHOLOGY(1400- 6); RESPIRATORY SYST-GENL STUD.METHS(1600t): BONE.JNTS.FASC.C- ONN/ADIP-ANATOMY(18002): BONE,JNTS,FASC.CONN/ADIP-PATH0L(18006); ROUTES OF IMMUNIZ.INF- ECT.TtlERAP(22100); TOXICOL-GENL/EXP STUDS.METHS(* 22501); TOXI COL -ENVIRONMNTL. INDUSTR(*22506) ; NEOPLSMS/NEOPL AGNIS-OIA- GNS Mr Tll( 24001 ) : NEQPLSMS/NEOPL AC.NTS-CARC ! NDGF.NS( 24007 ) ; 11! VE1 fll'MNTl. 111 fit. - GFN M0RPHGENS1 S( *25508 ) ; I Alton A I DRY ANIMALS-GENL' STUDS( 28002) : ENVIRON HE ALTH-11CCUPATNL MEALTMf *37013 ) ; ENVIRON HE ALTH-A I R ,WA T R . SL POL I.N ( * 370 1 5 ) ; PLANT PHYSIOL-METABOLISM(51519): PLANT PHYSIOL-CHEM CONSTITUENTS(51522) Blosystemattc Codes: PLANTAE-UNSPECIrI ED( MOOO): HOMINIDAE{- 86215): MURIOAE(86375) 74047833 REACTIONS OF VINYL CHLORIDE WITH RNA AND DNA OF VARIOUS MOUSE TISSUES IN-VIVO. BERGMAN K TOXICOL. LAB.. NATIONAL FOOD ADMINISTRATION. BOX 622. S-751 26 UPPSALA, SWEDEN. ARCH TOXICOL 49 (2). 1982. Language: ENGL ISH 117-130. Coden: ARTOO The irreversible binding of 14C-vinyl chloride metabolites to RNA and DNA of mouse brain, lung, liver, kidney, spleen, pancreas and testes after a single l.p. Injection was studied. Hydro lysates of nucletc acids from selected organs were separated on Amlnex A6 for quantItation of alkylation products. Radioactivity in nucleic acids was registered In all organs with the exception of brain. RNA from spleen, pancreas and liver and DNA from spleen and liver contained the highest amounts of radioactivity. In nucleic acids from spleen and pancreas. organs of high metabolic activity. the entire radioactivity was metabollcally !ncorpora ted as CI -f ragments. In RNA of kidney and liver a targe part of the radioactivity was present as Incorporated Cl-f ragments bu t 3,N4-ethenocyt1d1ne (In kidney}, and I,N6-ethenoadenos1ne and I ,N6-ethenoadenIne (In kidney and liver) were Identified ns alkylation products. In liver DNA 1ncorporat1 on of Cl-fragments was Insignificant, Indicating different Interactions of vinyl chloride metabolites (Cl-fragments and alkylating products) with RNA and DNA. The elution profiles of rad 1oacttv1ty In hydrolysates of liver DNA were dominated by an alkylation product of unknown structure (probably a derivative of deoxyguanos1ne). Possibly t,N6-ethenodeoxyadeno- sine and 1,N6-ethenoadenIne were also present In liver DNA. Results were consistent with the ability of vinyl chloride to act as a multipotent card nogen by alkylation of DNA in several tissues. Descriptors: BRAIN LUNG LIVER KIDNEY SPLEEN PANCREAS TESTES CARCINOGEN CARBON-14 LABEL INTRA PERITONEAL INJECTION Concept Codes: RADIATION BIOL-RADTN,ISOTOP TECHt06504 ) ; BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-NUCL ACD,PURNS,PYRM- (10062): BIOPHYS-GENERAL BIOPHYS TECH(10504): CHORDATE BODY REGNS-ABDOMEN( 113 14); MOVEMENT( 12 100); METABOLISM-GENL SIUO.METAB PATHW(* 13002) ; METABOLISM-NUCL ACD.PUR I NS.PYRIM( * 1 - 3014); DIGESTIVE SYST-PATHOLOGY(14006): BLOOD/BOOY FLDS-BLO.LYM,RES PATH{15006): BLOOD/BODY FLOS-LYMPI1AT T I SS ,RES(* 15008); URIN SYST/EXT SECR-PATHOLOGY(*15506 ) ; RE SPIRAIDRY SYST-PATHOLOGY(*16006); REPROOUCT SYST-PATHOLOGY( - 1G50G); ENDOCRINE SYST-GONADS.PLACENTA(17006); ENDOCRINE SYST-PANCREAS(* 17008); NERVOUS SYST-PATHOLOGY(20506); ROUTES OF IMMUNIZ.INFECT.THERAP(22100); TOXICOL-GENL/EXP STUDS,METI1S- (*22501): NEQPLSMS/NEOPL AGNTS-CARCI NOGENS( * 24007 ) 01onyslomnt 1c Codes: MUR I 0AE(86373) R&s 738344 DIALO le5: BIOSIS Previews 77-B3/dan BA7502;RRM2402(See F1le55) (c. BIOSIS 1982) (Item .25 of 858) User 3614 25Jan83 1990 74043361 EFFECT OF REPEATED VINYL CHLORIDE EXPOSURE ON RAT HEPATIC METABOLIZING ENZYMES. DU J T; TSENG M T; TAMBURRO C H UNIV. OF LOUISVILLE. TOXICOL APPL PHARMACOL Language: ENGL ISH 62 (1). 1982. 1-10. Codon: TXAPA Sprague-Oawley rats were exposed to 2.BY. vinyl chloride for 2 (70 h), 4 (140 h) and 6 (210 h) wk to determine the sequential biochemical changes related to the oxidation and detoxification ability of hepatic tissue. G.lu ta th lone-5 - t rans- ferase(s) activity using 1.2-epoxy-(p-n1trophenoxyIpropane and p-nItrobenzyt chloride as substrates was elevated 17-24. 28- and 35-42% after 2. 4 and 6 wk of exposure, respectively, suggesting enzyme(s) Induction. Reduced glutathione, the major substrate required to conjugate the toxic metabolites of vinyl chloride. was also consistently elevated. The activity of glutathione reductase. the enzyme necessary for the regeneration of reduced gluthlone from Its oxidized form, also Increased following vinyl chloride exposure. Cytochrome P-450, the major protein Involved with vinyl chloride metabolism, was reduced after vinyl chloride exposure, confirming reports that vinyl chloride metabolites destroyed P-450. No abnormalities of standard clinical biochemical blood tests of liver function were found during 6 wk of vinyl chloride exposure. The only consistent ultrastructural modification was the dilation of endoplasmic reticulum. The biochemical and u1trastruetura1 alterations reflected early hepatocellular adaptation to vinyl chloride exposure. Descriptors: GLUTATHIONE REDUCTASE GLUTATHIONE S TRANSFERASE CYTOCHROME P-450 Concept Codes: CYTDL0GY/CYT0CHEM-ANIMAL(O25O6); BIOCHEM STUD-GENERAL{10060); BIOCHEM STUO-PRQTEINS.PEPTIDES,AMI NO ACD(10064); BIOCHEM STUD-PORPHYRNS,BILE PIGM(10065); BIOPHYS-BIOENERGETICS(* 10510); BIOPHYS-BIOCYBERNETICS( 10515); ENZYMES-GEN.COMPAR STUO,COENZYMS(*10802>; ENZYMES-CHEM,PHYS1C- AL STUOlESt* 10806); PATHOLOGY-COMPARATIVE( 12503); METABOLI SM- - GENL STUD,MET AB PATHW(13002); METABOLISM-PROTNS.PEPTDS.AM ACOSt* 13012); METABOLISM-PORPHYRI NS.BILE PIGMN(* 130 13); DIGESTIVE SYST-GENL STUDS,METHS{ 1400 1 ); DIGESTIVE SYST-PATHOL- OGY(*14006); BLOOD/BODY FLDS-GENL STUDS,ME TITS( 1500 1 ); BLOOD/BODY FLDS-BLD,LYM.RES PATH{* 15006); BLOOD/BOOY FLDS-LYMPHAT TISS.RES(*15008); TOXJCOL-GENL/EXP STUDS,METHS( * - 22501); TOXICOL-ENVIRONMNTL,INDUSTR(2250G); IN VITRO STUDS-CELLULR.SUBCELL{32600) B1osystomat I c Codes: MUR I DAE(8C375) 74043339 THE GAS CHROMATOGRAPHIC DETERMINATION OF THIO DI GLYCOLIC-ACID IN URINE. MANCAS D G INST. IGIENA SANATATE PUBLICA. IASI. REV IG BACTER IOL VIRUSOL PARAZITOL EPIDEMIOL PNEUMOFTIZIOL SER IG 30 (4). 1981 (RECD. 1982). 337-340. Coden; RABID Language: ROMANI AN A new method for the gas chromatographic determination of urinary tli lodIgIyco1 Ic acid, a metabolite of vinyl chloride, was described. The method was based on the separation of the estertfled acid In a specially filled column. The sensitivity of the method was .apprx. 11 mg/1 urine. The Introduction of this simple and fast follow-up of changes involving vinyl chloride In humans occupationally exposed to this compound was recommended. Descriptors: HUMAN VINYL CHL0R10E OCCUPATIONAL HEALTH Concept Codes: CLIN BIOCHEM-GENL STUD IES(* 10006); BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUO-GENERAL( 10060); BIOPHYS-GE- NERAL BIOPHYS TECH(10504); MOVEMENT(12lOO): PATHOLOGY-GENERAL STUDIES! 1 2502); PATHOLOGY-DIAGNOST IC(* 12504); METABOLISM-GENL STUO,MET AB PATHW( 1300Z); URIN SYST/EXT SECR-GEN STUD,METH(15501); URIN SYST/EXT SECR-PHYSL.BIOCHEM(* 15504); TOXI COL -ENVIRONMNTL.INDUSTR(22506); ENVIRON HEALTH-OCCUPATNL HEALTHt*37013); ENVIRON HEALTH-A IR.WATR,SL POLLN( 370 I 5) B1osystemat1c Codes; MOM INIDAE 1862 15) 74042269 EFFECT OF FUNGICIDES ON THE ESTERASE ACTIVITY OF THE FUNGUS ASPERGILLUS-NIGER. ANISIMOV A A; LI NOVITSKAYA V M; SMIRNOV V F; BOCHKAREVA G G; KRAPIVINA E K GORKI STATE UNIV.. GORKI, USSR. PRIKL BIOKHIM MIKROBIOL PBMI A 17 (4). 1981. 605-608. Coden; Language; RUSSIAN Changes In the activity of esterases of the mycel fal fungus A. nlger were determined under the Influence of fungicides (merth1olate. TPBA (ammonium tetrafIuoroborate], trilane, AK-x [monochloracetarn 1 no rosin] and cataplne) used to protect PVC (polyvinyl chloride] materials against biological damage. The plastlflers d lootyLad 1p1nate. d1buty1sebac1nate and d1octy1sebac1nate, which are esters of adipinic and sebacic acids, were hydrolyzed by the esterases; dibutyl phthalate and dioctyl phthalate were resistant. The fungicides inhibited In varying degrees the esterase activity in the presence of certain plastlflers. Descriptors: PHY T 0 PATHOGEN MONO CHLOROACETAM 1 NO ROSIN AMMONIUM TETRA FLUORQ BORATE MERTHIOLAT E TRILANE CA1AP1NE ADIPINIC-ACID SEBACIC-AC ID ESTERS DI BUTYL PHTHALATE DJOCTYL PHTHALATE POLY VINYL CHLORIDE DAMAGE Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM ST UD-PROTE INS .PEPTIDES. AMINO ACD( 10064 ) ; ENZYMES - PHY S U)l DC. 1 CAL SIUDIESt10808); FOOD/INDUS M1CR0-FD/BEV SP CNI AM(* 39002); PLANT PHYSIOL-ENZYMES(*51518); PHYTOPATHOL-0 IS BY FUNGI(*5450- 2); PEST CONTRL GENL/PESTICS/HERBICS(* 54600) B1osys tema t1c Codas: OEUTEROMYCETES( I 5500); MYCOLOGY(95000) ABSTRACTS OF DIALOG e5: BIOSIS Previews 77-83/Uan BA7502;RRM2402 ( See File! (c. BIOSIS 1982) (Item 28 of 858) User 3614 25janl 199 1 74031960 CYTO GENETIC EFFECTS OF EPOXY PHENOL FORMALDEHYDE AND POLY VINYL CHLORIDE RESINS IN MAN. SUSKOV I I; SAZONOVA L A INST. OF GENERAL GENETICS, ACADEMY OF SCI. OF THE U S.S.R., MOSCOW 117333 U.S.S.R. . MUTAT RES 104 (1-3). 1982. Language: ENGL ISH 137-140. Coden: MURE The cytogenetic analysis of persons occupationally exposed to synthetic resins revealed a true increase In the average frequency of cells with chromosome aberrat1ons: 5.5/if or epoxy resin (146 persons). 6.1*/, for po 1 yv I ny 1 ch 1 or 1 de (52 p ersons), and 5,0'/. for pheno 1 formal dehyde (31 persons). An Inc I dence of 2.4'/, was observed In the control (74 persons). The average frequency of aberrant chromosomes/cell for all the s ynthe t1c resins (0.054-0.065) .differed from the control. The average frequency of chromosome breaks/chromosome did not differ significantly from the control. Acentric fragments (s1 ngle and paired) was the prevalent type of aberration. Descriptors: OCCUPATIONAL EXPOSURE CHROMOSOME BREAK ACENTRIC FRAGMENT Concept Codes: CYTOLOGY/CY TOCHEM-HUMAN( *02508); GENE TICS/CY- TOGENT-HUMAN(*03508); SOCIAL BIOL/HUMAN ECOLOGY (05500): B10CHEM STUD-GENERAL( 10060): TOXI COL-ENVIRONMNTL.I NOUS TR(*225- 06): ENVIRON HEA LTH-OCCUPA T NL HEALTHt*370 13); E NVI RON HEALTH-AIR.WATR,SL POLLN{*37015) B losys temat1c Codes: HOMINIDAE(86215) R&S 138345 74028784 PHYSIOLOGIC AND HYGIENIC EVALUATION OF WORKING CONDITIONS IN POLY VINYL CHLORIDE BASED SYNTHETIC LEATHER MANUFACTURE. TURBIN E V; ALDYREVA M V: MATYUKHIN V V INST. IND. HYG. OCCUP. DIS., ACAD. MED. SCI. USSR. MOSCOW, USSR . GIG TR PROF ZABOL 0 (8). 1981. 30-35. Coden: GTPZA Language: RUSSIAN Similar shifts in the body function occur (n male and female primers due to exposure to adverse effects. These shifts were manifested In fatigue by the end of the working day. The earliest and most expressed signs were recorded after 3 h of work in mill and calender operators. checkers and female primers employed In the manufacture of tube pavlnol. In the latter workers, exposed to combined effects of phosphate and phthalate plasticizers, more early and expressed changes tn physiologic functions were detected than In workers exposed to phthalate alone. The labor of male and female primers, due to physiologic differences In male and female body, was referred to various categories of strain. Descriptors: HUMAN PRIMER Concept Codes: SOCIAL BiOL/HUMAN ECOLOGY(05500>; 8I0CHEM Srun-GENERAL( 10OG0): PATHOLOGY-GENERAL SIUD1ES( 12502); PATHOLOGY-COMPARATIVE(12503); METABOLISM-GENL STUO,ME TAB PATHW(13002); TOXICOL-ENV1RDNMNTL,INDUSTR(22506): ENVIRON HEALTH-OCCUPATNL HEALTH{*370i3): ENVIRON HEAL1H-A IR,WATR,SL POLLN(*37015) B 1 osystemat 1 c .Codes : HOMINIOAE {862 15) DULOG^Xe5: BIOSIS Previews 77-83/dan Oatco''! , r>mi* f R&S 138346 74025730 .LIFE SPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS. FERON V 0; HENDRIOSEN C F H; SPEEK A J; TIL H P; SPIT B U INSTITUTE ClVO-TOXICOL. NUTRITION TNO. PO BOX 360, 3700 AJ, ZEIST. THE NETHERLANDS. FOOD COSHET TOXICOL Langvjacje; ENGLISH 19 (3). 1981. 317-334. Coden: FCTXA A lifespan oral tox\c 11 y s tudy of vIny1 chI or 1de monomer (VCM) was carried out In Wlstar rats, using 5 groups each of 60-80 males and 60-80 females. VCM was administered by incorporatIng polyvinyl chloride (PVC) powder with a high VCM content Into the diet or by gastr.lc Intubation of a 107. VCM solution In soybean oil. The VCM doses (actual exposures) were 0 (control), 1.7, 5.0 and 14. 1 mg/kg body wt per day prov1ded by diets containing PVC powder and 300 mg/kg body wt given by stomach tube as a solution of VCM In oil on 5 days/wk. The death rate was higher In all VCM-treated groups than In controls and Increased with 1ncreas1ng VCM doses. The 14.1- and 300-mg/kg treatments were associated with shortened blood-clotting times. slightly Increased .a 1pha.-fetoprote1n levels In the blood serum, liver enlargement and an Increased hematopoietic activity In the spleen. A variety of neoplastic and non-neoplastIc treatment-related liver lesions was found at each VCM level. The changes varied from swollen and 1rregu1arly-shaped mitochondria In hepatocytes to hepatoce11u1ar care 1 nomas and hepat1c ang1 osarcomas. The tumor rosponso of tho liver appeared to shift from a predominance of angiosarcomas at the highest dose level via a mixture of angiosarcomas and hepatocellular tumors at the Intermediate levels to the exclusive development of hepatoce1tu1ar tumors at the lowest VCM level. Tumors attributable to VCM exposure and found at other s 1 tes . Included pulmonary angiosarcomas, extrahepa11c abdom1na1 angiosarcomas and tumors of the Zymba1 glands; these neoplasms occurred at VCM levels of 5.0 mg/kg and above. .VCM exposure enhanced the development of abdominal nosothellomas and of adenocarcinomas of the mammary glands. Orally administered VCM Is a carcinogen In rats, and that the no-observed-adverse-effect level In rats was lower than 1.7 mg/kg body weight/day under the rigorous conditions of continuous oral VCM exposure resulting from the release of VCM from PVC powder present In the gastro-1ntestIna1 tract. Descriptors; CARCINOGEN HEPATO CELLULAR CARCINOMA HEPATIC ANG10 SARCOMA PULMONARY ANG10 SARCOMA ABDOMINAL ANG10 SARCOMA ZYM8AL GLAND TUMOR MAMMARY GLAND ADENO CARCINOMA MESOTHELIOMA SOYBEAN OIL Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); 8I0CHEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064); BIOCHEM STUD-LIPIDS( 10066); BIOCHEM STUD-CARBOHYD- R. ( 10068); ANATOMY/HISTOL-MICRO,ULTRAMICRSC(* 11106); CHOROATE BODY REGNS'ABDOMEN!11314); PATHOLOGY-NECROSIS{12510); METABOL ISM -CARBOHYORATES( 13004); METABOLISM-PROTNS,PEP1 OS.AM ACDS( ID- 012): DIGESTIVE SYST-GENL STUDS,METMS(14001); DIGESTIVE SYST-PATHOLOGY!* 14006); CARDIOVASC SYST-BLD VESS PATHOL(1450- 8); BLOOO/BOOY FLDS-BLOOD,LYMPH STU0(15002); BLOOO/BODY FLDS-LYMPHAT TISS.RES{15008): RESPIRATORY SYST-PATHOLOGY(*16O- OG); REPRODUCT SYST-PATHOLOGY(*16506); ENDOCRINE SYST-GENERAL STUDIES(* 17002); INTEGUMENT SYST-PATHOLOGY( * 18506 ) ; DENTAL/UR AL BIOL-GENL STUD.METHSf 19001); ROUTES OF IMMUNIZ.INFECT,THER- (c. BIOSIS 1982) (Item 30 of 858) User 3614 25Ja 1992 AP(22lOO); TOXICOL-GENL/EXP STUOS,METHS(*22501) ; NEOPLSMS/NEO- PL AGNTS-CARCINOGENSt*24007); DEVELOPMNTL B1OL-CENL.OESCR IPT I - VE(2 5502); PLANT PHYSIOL-CHEM CONST 1TUENTS(5 I 522 ) ; AGRONOMY-OIL CH0PS(52514) Bfosystemat1c Codes: LEGUMINOSAE(26260}; MUR!OAE(8637 5 ) DIALOG F11e5: BIOSIS Previews 77 ** t c;ee p | i e5S) (c. BIOSIS 1982) (Item 37 of 858) User 3G14 25Jan83 1995 R&S 138349 74013496 RELATIONSHIP OF CONCENTRATIONS OF VOLATILE SUBSTANCES RELEASED FROM POLY VINYL CHLORIDE LINOLEUMS AND AMBIENT TEMPERATURE. VASIL'EVA T S; MAL'TSEV V V ALL-UNIDN RES. INST. DES.-CONSTR. INST. PDLYM. CONSTR. MATER., MOSCOW. USSR. GIG SANIT O (6). 1981. 15-17. Coden: GISAA Language: RUSSIAN The concen tra tlons of volatile substances (benzene. ethylbenzene, etc.) released from polyvinyl chloride linoleums of various types were studied In relation to amblent temperature. The activation energies of the diffusion of these substances were determined to calculate Increases In concentrations of Individual substances with r1s1ng tempera ture on the basis of their concentra t1ons a t 20.degree. c. Descriptors: BENZENE ETHYL BENZENE AIR POLLUTION Concept Codes: GENERAL FIELD APPARATUS(0iO10); ECOLOGY-GENL STUDIES.METHODS(07502); ECOLOGY-BIOCLIMATOL.BIOMETEOROL(*07504); BIOCHEM-GASES(10012); BIDCHEM METH-GENERAL(* 10050): BIOCHEM STUD-GENERAL( 10060); EXTERN EFF-TEMPERATURE(* 106 14); EXTERN EFF-HO T( 106 18); TOXICOL-ENVIRONMNTL.INOUSTR(22506); TEMPERATURE-GENL,METHS{2300 t); TEMPERATURE-HYPO,HYPERTHRMIA(23006); ENVIRON HEALTH-AIR,VATR- ,SL POLLN(*37015) 74009872 TESTS FOR MUTAGENICITY IN SALMONELLA AND COVALENT BINDING TO DNA AND PROTEIN IN THE RAT OF THE RIOT CONTROL AGENT 0 CHLOROBENZYLIOENE MALONONITRILE. VON DAN IKEN A; FRIEDERICH U; LUTZ W K; SCHLATTER C INST. TOXICOL.. SWISS FEDERAL INST. TECHNOL., CH-8603 SCHWERZENBACH, SWITZERLAND. ARCH TOXICOL 49 (1). 19BI (RECD. 1982). 15-28. Coden: ARTOD Language: ENGLISH o-Chlorobenzy1Idene ma1onon1trt1e (CS) was studied for any genotox 1c activity towards Sa1 monel 1 a or mamma 1 1 an ONA' In vivo. CS was synthesized with a [!4C]-labol at the benzyl 1c carbon atom. It was hdm1n1stercd I.p. at a dose 1ovo1 of 13 mg/kg (l mCl/kg) to young adult male rats. Liver and kidney DNA was Isolated after 8, 25 and 75 h. The radioactivity was at (liver, 8 and 75 h) or below (all other samples) the limit of detection of 3 dpm. A possible binding of CS to DNA Is at least 105 times 1ower than the s t rong hepa toearc I nogen aflatoxln Bl, and 4000 times tower than vinyl chloride. In contrast to this lack of DNA binding, but In agreement with the chemical reactivity of CS, a binding to nuclear proteins could be detected with specific activities ranging between 50-121 dpm/mg for liver and between 3 and 41 dpm/mg for kidney. Protein binding could well be responsible for Its pronounced cytotoxic effects. CS was also tested In the Ames Sa1mone11 a/m 1crosome assay. Strains TA 1535, TA 1537, TA 1538. T* n - --- t r* Only with strain TA 10O and only without pro-InculwtIon. a doubling of the number of revertsnts was detectable at the highest dose levels used, 1000 and 2000 .mu.g CS/plato. With pre-tncubatIon of TA 100 with CS. a slight Increase of the number of revertants was seen at 100 and 500 .mu.g/pla te, and a subsequent fait bolow control values at 1000 .mu.g. A check for the number of surviving bacteria revealed a strong bacterlotoxtclty of the higher doses of CS so that the calculated mutation frequencies, the number of revertants/number of surviving bacterla. Increased with doses up to 500 .mu.g. This toxicity could be counteracted tn part by the addition of Increasing amounts of rat liver mlcrosomes. Taking Into account the rare and low exposure of man, CS will not create a risk for the Induction of point mutations or of carcinogenic processes mediated by DNA binding. Descriptors: HUMAN LIVER KIDNEY AFLA TOXIN B-1 VINYL CHLORIDE GENO TOXIC ACTIVITY POINT MUTATION CARCINOGENIC PROCESS Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL{*02506 ) ; GENETICS/C- YTOGENET- AN IMAL(*03506); GENETICS/CYTOGENET-HUMAN(*03508); RADIATION HI0L-RA0TN.ISOTOP TECH(06504); BIOCHEM STUD-GENERAL- ( IOOGO); BIOCHEM STUD-NUCL ACD,PURNS,P Y RM( 1006 2); BIOCHEm' STUD-PROTEINS,PEPTIDES.AMINO ACD(10064); CHORDATE BODY REGNS-ABDOMEN(11314); METABOLISM-PROTNS.PEPTDS,AM AC0S(*13012) ; ME TABOLISM-NUCL ACD.PUR I NS.PYRIM( 13014); DIGESTIVE SYST-GENL STUDS.METHS( 14 001 ); UR IN SYST/EXT SECR-GEN STUD.METH(15501); ROUTES OF IMMUNIZ.INFECT,THERAP(22100): TOXICOL-GENL/EXP STUDS.METHS(*22501): NEOPLSMS/NEOPL AGNTS-CA- RCI NOGENS( *2 4007); BACTERIAL AND VIRAL GENETICS(*31500}: MED/CLIN MICROBIOL-MYCOLOGY(36008); PLANT PHYSIOL-CHEM CONSTITUENTSI51522) Blosys tematIc Codes: ENTEROBACTERI ACEAE(04 810); OEUTEROMYCE - TES( 15500); HOMINI DAE(86215); MUR I DAE(86375 ) DI ALO e5 : BIOS! ".le 77-83/Jan 8A7502;RRM2402(See F 1 1 R&S 138350 74009095 EFFICACY ANO MODE OF ACTION OF INSECTICIDE IMPREGNATED EAR TAGS AND LEG BANOS FOR CONTROL OF CATTLE GRUBS HYPODERMA-LINEATUM. MILLER U A; KUNZ S E: BEAOLES M L U.s. LIVESTOCK INSECTS LAB.. AR, SEA. USDA, KERRVILLE. TX 7802B. SOUTHWEST ENTOMOL Language: ENGLISH 6 (3). 1981. 265-268. Codon: SENTD In field tests conducted In Texas [USA] In 1979 and 1980, polyvinyl chloride (PVC) ear tags containing dfchlorvos (2.2-d1 chiorov1ny1 dimethyl phosphate) were as effective as leg bands for the control of the common cattle grub, H. Ilneatum (Vlllers), In cattle. The mode of action of such treatments was systemic. Leg bands containing fenvalerate (cyanot 3-phenoxypheny1)methy1 4-chloro-.a 1pha.-(1-methylethylibenzeneacetate) were Ineffect ive; however, fewer grubs were found in cattle treated with fenva1 erate-tmpregnated ear disks than tn untreated controls. If leg bands or ear tags containing a systemic Insecticide such as dlchlorvos are applied soon after the heel fly season, control of both tho horn fly, Haematobla irrltans (L.), and the common cattle grub can be expected. Descriptors: HAEMATDBIA - IRRITANS CATTLE POLY VINYL CHLORIDE OICHLORVOS FENVALERATE TEXAS USA Concept Codes: BIOCHEM STUD-GENERAL<10060); CHORDATE BODY REGNS-HEA0(11304); CHORDATE BOOY REGNS-EXTREM1TIES( l1318); TOXICOL-GENL/EXP STUDS.METHS(22501); ANIMAL PRODUCTN-GENL STUDS.METHS(*26502); PEST CONTRL GENL/PEST ICS/HERBICS(*54600); ECONOM ENTOMOL-ANIMAL PESTS(*60012); ECONOM ENTOMOL-CHEM PHYS CONTRL(*60016) Biosystemat 1c Codes: OIPTERA(75314); BOVIDAE ( 857 15 ) ABSTRACTS OF ENTOMOLOGY(96000) {c. 8I0SIS 1982) (Item 39 of 858) User 3614 1 996 NERAL BIOPHYS TECH(10504): MOVEMENTt121OO): PATHOLOGY-GENERAL STUDI ES( 12502 ) ; PATHOLOGY - DI AGNOST IC( * 12504 ) ; ME T AflDL l SM- GENL STUD.ME T AB PATHW( 13002); UR IN SYST/EXT SECR-GEN STUO,METH<15501); URIN SYST/EXT SECR-PHYSt.BIOCHEM( * 15504 ) ; T OX I COL -ENVIRONMNT L,INOUSTR(* 22506): ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVI RON HEALTH-A IR,WATR.SL POLLN{* 37015 I Biosystemat1c Codes: H0MINI0AE(86215) 74006832 CHROMATOGRAPHIC DETERMINATION OF THIO DI GLYCOLIC-ACID A METABOLITE OF VINYL CHLORIDE. DRAMINSKI W; TROJANOWSKA B INST. OF OCCUPATIONAL MED.. DEP. OF METABOLISM OF TOXIC SUBSTANCES. TERESY 8, PL-9O-950 LODZ. POLANO. ARCH TOXICOL 48 (4). 1981. 289-292. Coden: ARTOD Language: ENGLISH The determination of thlodlglycoltc acid (TDGA) In urine by gas chroma tography (GC) was doscr1 bed. The analytical procedure Included addition of Interna 1 standard (o-phtha 11c acid), ethyl acetate extraction. evaporation of the solvent and sllylatfon of TDGA with N-trImethy 1s11y1dIethy1 am 1ne In pyridine (1:1). Results were calculated from the ratio of TDGA and Internal standard peak heights. The detection limit of tho method was *10 mg/1 and the coefficient of variation was .+-. 5%. This method could be usoful In evaluating worker exposure to vinyl chloride. Descriptors: HUMAN URINE OCCUPATIONAL HEALTH Concept Codes: GENERAL FIELD METt 10DS(01008); GENERAL FIELD APPARATUS(OIOIO): CLIN BIOCHEM-GENL STUDIES{* 10006); BIOCHEM METH-GENERAL(* 10050): BIOCHEM STUD-GENERAL( 10060); BIOPMYS-GE- R&S 138351 DIALOG F1!e5: BIOSIS Previews 77-83/dan BA7502:RRM2402(See F11e55) (c. BIDSIS 1982) (Item 41 of 858) User 3614 25jan83 1997 74004280 STABILITY AND COMPATIBILITY OF ANTI TUMOR AGENTS IN GLASS AND PLASTIC CONTAINERS. BENVENUTO U A: ANDERSON R W; KERKOF K; SMITH R G: LOO T L DEP. OF DEVELOPMENTAL THERAPEUTICS, M.D. ANDERSON HOSP. AND TUMOR INST., HOUSTON. TX 77030. AM J HOSP PHARM 38 (12). 1981. 1914-1918. Coden: AJHPA Language: ENGLISH The stability of methotrexate. f1uorourac11, cytarablne, dact1nomycIn. doxorubicin, bleomycin sulfate, mitomycin, mlthramycln, vincristine sulfate, vinblastine sulfate, cyclophosphamide. dacarbazine, carmustlne and leucovorln calcium In underfilled plastic and glass administration conta1ners was determined. Drugs were reconstltuted according to manufacturers' Instructions and added to 5% dextrose Injection 50 ml In both partial-fill bottles. Injection 50 ml In both partial-fill bottles. polyvinyl chloride bags and glass Nitomycln was added to 0.9'/. NaCl polyvinyl chloride bags and glass A11 admIxtures were stored at room temperature, unprotected from light. Stability was determ 1ned over 24 h (48 h for doxorubicin and fluorourac11) high-pressure liquid chromatography. except cyclophosphamide (analyzed by mass spectrometry) by for and carmustlne (analyzed by spectrophotometry). Methotrexate, 1 eucovor In calcium, cytarablne, dac t .1 nomyc In, ml thramyc 1 n. vinblastine sulfate, cyclophosphamide and dacarbazine were equally stable (10*/. or less change In concentration over 24 hours) In glass and plastic containers. Doxorub(cIn and f1uorouracII were more stable in plastic containers than glass containers. The T90 value for doxorubicin In glass was 40 h; there was no apparent decrease In plastic even after 48 h. The T90 value for fluorouracil In glass was 7 h and In plastic, 43 h. Vincristine sulfate, bleomycin sulfate and carmustlne were more stable In glass than plastic. Tho T90 value for vincristine sulfate In plastic was 10 h, for bleomycIn sulfate 0.7 h. and for carmustlne 0.6 h. Mitomycin dissolved In 0.9"/, NaCl Injection was more stable In plastic. Mitomycin dissolved In 5'/. dextrose Injection was not stable. Carmustine and bleomycin sulfate should be administered only In glass containers. Continuous Infusions of doxorubicin and f1uorourac11 are more complete!y delivered f rom plastic containers. Mitomycin should not be dissolved In 5% dextrose Injection. Descriptors: METHOTREXATE FLUORO URACIL CYTARA8INE DACTINOMYCIN DOXORUBICIN BLEOMYCIN SULFATE MITOMYCIN MITHRAMYC1N VINCRISTINE SULFATE VINBLASTINE SULFATE CYCLO PHOSPHAMIDE DACARBAZINE CARMUSTINE LEUCOVORIN CALCIUM ANTINEOPLASTIC-ORUG POLY VINYL CHLORIDE BAGS GLASS PARTIAL FILL BOTTLES 5 PERCENT DEXTROSE INJECTION Concept Codes: 810C1IEM METH-GENERAL( 10050): BIOCNEM STUD-GENERALc10060); BIOCHEM STUD-V I TAMINS{ 10063); BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(10064); BIOCHEM STUO-CARBOHY- DR.(10068); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPIIYS-MOLE- CUL PROP,MACROMOLEC(* 10506); EXTERN EFF-LIGHI,OARKNESS( 10604); EXTERN EFF-TEMPERATURE(10614); MOVEMENT(1210O); CARDI0VA3C SYST-GENL STUDS.METHS( 14501): PHARMACOL-GENERAL STUDIES(* 2200- 2); ROUTES OF IMMUNIZ.INFECT.THERAP(221OO); TEMPERATURE-GENL.- CHEMOTHERAPY-GEN STUD.METIt,METAB(*38502): PLANT PHYSIOL-CHEM CONSTITUENTSI51522); PHARMACOGNOSY/PHARMACEUT HOTANY(54000) B 1 osysternat1c Codes: APOCYNACEAE(25580) 74004057 INHALATION PHARMACO KINETICS BASED ON GAS UPTAKE STUDIES 3. A PHARMACO KINETIC ASSESSMENT IN MAN OF PEAK CONCENTRATIONS OF VINYL CHLORIDE. BOLT H M; FILSER J G; 8UCHTER A ABTEILUNG FUER TOXIKOLOGIE, PHARMAKOLOGISCHES INSTITUT DER UNI VERS IT AET MAINZ OBERE ZAHLBACHER STRASSE 67, D-6500 MAINZ 1. ARCH TOXICOL 48 (4). 1981. 213-228. Coden: ARTOO Language: ENGLISH On the basis of previous determinations of pharmacokinetic parameters for Inhaled vinyl chloride and on Improved pharmacokinetic models, a pharmacokinetic treatment of the problem of peak concentrat Ions of vinyl chloride, as occurring in industrial practice, became possible. Metabolic elimination kinetics of vinyl chloride was assumed to be 1st order as exper Imonla1 evidence showed 1 1 near pharmacok1 notIcs up to atmosphdrlc exposures of 200-300 ppm. The distribution of vinyl chloride between atmosphere and organism under different condIttons was evaluated using s teady-s tate-klnetics. The numerleal values for the parameters derived from a human kinetic experiment were used to calculate the time courses of vinyl chloride concentration in the organism and the cumulative amount of vinyl chloride metabolized under a 2 h constant exposure to 5 ppm vinyl chloride and subsequent peaks of 50 ppm with a duration of 5 min each. This model caIcu1 a t1 on suggested that the omoun t of (reactive) metabolites formed from vinyl chloride would be a function of the mean atmospheric vinyl chloride concentrstIon over time. As the concentratlon of the reactive metabolite of vinyl chloride responsible for the carcinogenic effect at the target site must be a result of forma tlon and Inactivation. an evaluation of the differential risk of different exposuro profiles can reasonably bo based on biochemical examinations of the detoxifying pathways. This points out the relevance studies of the patterns of different metabolites of vinyl chloride In man under varying exposure profiles. Descriptors: CARCINOGEN Concept Codes: MATHEMATIC BIOL/STATISTIC METH{04500): BIOCHEM STUO-GENERALI 10060); MET ABOLISM-GENL STUO.METAB BIOPHYS-8IOCYBERNETICS( 105 15); PATHW{* 13002): RESPIRATORY SYST-PHYSIOL,BIOCHEM(* 16004); TOXI COL -GENL/EXP STUDS,ME TKS(* 2 - 2501 ); TOXI COL -ENVIRONMNTL. INDUSTR(*22 506 ) ; NEOPLSMS/NE0PL AGNTS-CARC1NOGENS(* 24007); ENVIRON MEALTH-OCCUPATNL HEAL TH(37013): ENVIRON ilFALTH-AIR,WATR.SL P0LLN(3701G) Blosystemqt1c Codes: HOMINIDAE(862 1 5) DI ALOC^B e -------- ''-3/jan BA 7502 ; HR M 7.4 02 (See R&S 138352 73080449 EFFECT OF AIR EXCHANGE ON THE CONCENTRATION OF VOLATILE SUBSTANCES DIFFUSED FROM POLY VINYL CHLORIDE LINOLEUMS. VASIL'EVA T S; MAL'TSEV V V; KUDRYAVTSEVA G A ALL-UNION RES. DES.-CONSTR. INST. POLYM. CONSTR. MATER.. MOSCOW, USSR. GIG SANIT GISAA 0 (11). 1980 (RECD. 19B1). 59-62. Coden: Language: RUSSIAN Quantitative studies were carried out on the effect of. the air exchange multiplicity factor [AEMF] on the concentration of separate volatile substances [VS] diffused from polyvinyl chloride linoleum [PVCL]. Two types of linoleum wore tested, a 1inoteura coated with printed film [CPF] and a monolayered ro11ed-ca1andored [MLRCJ linoleum. Gas chromatographic analysis of VS revea1ed the presence of unsaturated and aromatic hydrocarbons (hexene-!, benzene, toluene, ethylbenzene, decene-1, cumene. mesttylene and other substances) In the air above the PVCL. Air exchange at 0.25 vol/h decreased the concentration of most VS to the maximum permissible level. Increased air exchange had a lesser effect on the concentration of substances with a higher boiling point (ethylbenzene in MLRC linoleum). With air exchange at 0-3 vol/h (typical for living quarters). concentration of ethylbenzene decreased by 1/2 while concentrations of hexene-1 and benzene (In CPF linoleum) decreased 10- to 12-fold. Properties of the volatile substances and surface materia) through which the VS diffused had an efect on the nature of changes In Individual VS. Descriptors: HOME INDOOR AIR POLLUTION Concept Codes: GENERAL FIELD METH00S(01008); GENERAL FIELD APPARATUS(O1010); PHOTOGRAPHY-METHS.MATLS,APPARAT(0lO12); SOC IAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM-GASES(10012): BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUO-GENERAL( 10060); BIOPHYS-GE- NERAL BIOPHVS TECH(10504); TOXICOL-ENVIRONMNTL,INOUSTR(22506); ENVIRON HEALTH-AIR,WA7R.SL POLLN(*37015) 73076992 ROLES OF 2 HALO ETHYLENE OXIDES AND 2 HALO ACETALDEHYDES DERIVED FROM VINYL BROMIDE ANDVINYL CHLORIDE IN IRREVERSIBLE BINDING TO PROTEIN AND DNA. GUENGERICH F P; MASON P S; STOTT W T; FOX T R; WATANABE P G DEP. B10C11CMIS TRY CENT. ENVIRONMENTAL TOXICOL., VANDERBILT UNIV. SCH. MED., NASHVILLE. TENNESSEE 37232. 'CANCER RES CNREA 41 (11 PART 1). 1981. 4391-4398. Codon: Language: ENGLISH The metabolism of [ 1.2 - 1 4C ] vIny1 bromide (VBH) (which appears tq bo carcinogenic In animals) to products Irreversibly bound to DNA and protein was examined In rat liver mlcrosomes, reconstituted cytochrome P-450 systems and isolated hepa tocy tes. A role for cytochrome P-450 was confirmed using Inhibition and reconstitution experiments. The major form of cytochrome P-450 Involved in V8R metabolism does not appear to bo either of the major Isozymes Induced by phenobarb11a 1 or .beta.-naphthoflavone, as determined by (c BIOSIS 1982) (Item *13 of 858 ) User 3614 25Jan03 1998 Induction. recount Itvl Ion and antibody Inhibition studios. 2 - Br omoe t hy 1 one oxide and 2 - brornonco t a l deliy do . suspected metabolites of VBR, were synthesized and found to be substrates for rat liver epoxide hydrolase and equine liver alcohol dehydrogenase, respectively. These enzymes were used to probe the roles of the 2 possible metabolites In the Irreversible binding of products of VBR to protein and DNA. Alcohol dehydrogenase was more effective than epoxide hydro 1 a se In I nhlbIt1ng t he bind 1 ng VBR me t abo lltes to protein In microsomal Incubations. Epoxide hydrolase was effective In Inhibit)ng the b tnd1ng of VBR or v 1 ny1 chloride me tabolltes to calf thymus DNA added to such systems, but alcohol dehydrogenase was not. Similar results were obtained for binding of VBR metabolites to ONA In a reconstituted enzyme system. Reduced glutathione blocked nonenzymnt1c binding of 2-bromof 1.2 - 1 4C)aceta 1dehydo to protein but not DNA. Binding of vinyl chloride and VBR metabolites to protein was blocked by reduced glutathione. but binding to DNA was not. Those results are consistent with the view that 2-ha loo. thy 1 ene oxides are the major alkylating agents bound to protein In these experimental'. systems. Studies with labeled 2-bromoaceta1dehyde Indicate that the slow kinetics of DNA binding by this compound Is responsible In part for this phenomenon. Studies with isolated rat hepatocytes suggest that a significant portion of the total and reactive metabolites are able to leave these cells. In these systems. binding of metabolites of vinyl chloride to DNA outside the hepatocytes could be partially blocked by epoxide hydrolase or by alcohol dehydrogenase. Implying that, as targets farther away from sources of reactive species are considered, the stabilities of those species become more Important for reaction with nuc1eoph111c si tes. Descriptors: RAT HORSE CALF LIVER THYMUS CARCINOGEN GLUTATHIONE CYTDCHROME P-450 PHENO BARBITAL BETA NAPHTHO FLAVONE EPOXIDE HYDROLASE ALCOHOL DEHYDROGENASE NUCLEOPHILIC SITE ANT I BOO Y INHIBITION STUDY Concept Codes: RADIATION BIDL-RADTN,ISOTOP TECH(06504); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUO-NUCL ACD,PURNS,PYRM- (10062); BIOCHEM STUD-PROTEINS,PEPTIDES.AM I NO ACD{ 10064); BIOCHEM STUD-PORPHYRNS.BILE P1GM{ 10065); 8I0PHYS-MOLECUL PROP ,MACH0M0LEC(* 10506); EN2YMES-METHODS( 10S04); ENZYMES-PHYS- IOLOGICAL STUD IES{* 10808); METABOLISM-GENL STUD,ME TAB PATHWf* 13002); METABOLISM-PROTNS.PEPTDS.AM ACDS('130 12); ME T ABOLISM-NUCL ACD,PUR I NS,PYH1M( 13014) ; DIGESTIVE SYST-PATH- OLOGY( 14 006); BLDOO/BODY F LOS-LYMPHAT TISS.RE S( 15008 ) ; ENDOCRINE SYST-THYMUS( 1 70 1 6); PHARMACDL-ORUG ME TAB.METAB ST IMU{22003); TOX1 COL-GENL/EXP STUDS,METHS(*2250 1 ) : NEOPLSMS/- NEOPL AGNT S-CARCINOGENS(*24007); IMMUNOL/IMMUNOCHEM-GEN ME Tl I ( 3 4 502 ) 8 losystnmatIc Codes: B0V1 OAE ( 857 t 5 ) ; FOtl t OAE { 86 1 4 5 ) ; MUR IDA (86375) R&S 138353 DIALOG Flle5: BlOSia Previews 77-83/dan BA7502;RRM2402(See F11c55) (c. BIOSIS 1982) (Item 45 of 858) User 3614 25Jan83 1999 73076949 MALIGNANT TUMORS AFTER CHRONIC EXPOSURE TO VINYL CHLORIDE. EMMERICH K H; NORPOTH K INST. PATHOL.. MUENSTER. W. GER. UNIV. MUENSTER. DOMAGKSTR. 17, 0-4400 d CANCER RES CLIN ONCOL 102 (t). t9Bt (RECD. 1982). Coden: dCROD 1-12. Language: ENGLISH Correlations between exposure to vinyl chloride and the development of malignant tumors In the liver have been known since 1974 and have been confirmed by many experimental Investigations. Based on the evaluation of [human] mortality statistics from 9 different countries an Increased incidence of malignant tumors of the lung. the gastrointestinal tract and the central nervous system (CNS) and of malignant lymphomas Is documented in connection with exposure to vinyl chloride. Statistically significant Increases were only found In the IncIdence of ma1Ignant liver tumors. Metabolism and toxicology of vinyl chloride are discussed In detail. Descriptors: HUMAN LUNG GASTRO INTESTINAL TRACT CENTRAL NERVOUS SYSTEM CARCINOGEN MORTALITY STATISTICS Concept Codes: MATHEMATIC BI0L/STAT I ST IC MTH(04500); BIOCHEM STUD-GENERAL( IOOGO); PATHOLOGY-NECROSIS( 12510); METABOLISM-GENL STUD.META8 PATHW(* 13002); DIGESTIVE SYST-PATH0L0GY{* 14006); 8L00D/B0DY FLDS-8LD,LYM,RES PATH(I500- 6); BLODD/BODY ELDS-LYMPHAT T!SS.RES(15000): RESPIRATORY SYST-PATH0L0GY(16006); NERVOUS SYST-PATHOLDGY(20506); TOXICOL-GENL/EXP STUDS.METHSt*22501): TOX]COL-ENVIRONMNTL.INO- USTR(*22506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007): NEOPLSMS/NEOPL AGNTS-BLOOD.RES(24010); PUB HEALTH-ADM INISTR. STATISTICS(37010); EPI DEMIOL-ORGANIC DIS,NEOPLASMS(37054) B1osystemat1c Codes: HOMINIDAE(86215) period should not be < 20 days. Even at the high sealing levels achieved, wind caused gas loss from some regions, particularly corners of the stack. and Increased local dosing of those regions was recommended. At the rates of gas loss observed. 5-15% day-1 overall, and dosage rate used, phosphine was retained at Insecticidal levels through the treated bulks for > i mo. All caged test Insects, Including pupae of SI tophilus granarlus, were killed at a Ct product of 20 g h m-3 over 28 days. There were no significant differences In the results obtained which could be attributed directly to differences between the phosphIne-generat1ng used. preparations Descriptors: SI TOPHILUS-GRANAR I US INSECTICIDE WIND Concept Codes: ECOLOGY-BIOCLIMATOL.BI0METE0R0L(07504): 8I0CHEM-GASES(* 10012); BIOCHEM STUD-GENERAL( 10060): PATHOLOGY- -NECROSIS( 12510): FOOD TECH-PREP.PROCESSNG,STORAGE(* 13532 ) ; TOXICOL-GENL/EXP STUDS.METHS(* 22501 ) ; AGRONOMY-GRA IN CROPS( * 5- 2504); PEST C0N7RL GENL/PESTICS/HERB1CS(546001: ECONOM ENT0M0L-ST0RE0 PRODUCTS(*60008); ECONOM ENTOMOL-CHEM PHYS CONTRLC*60016); INVERTS PHYSIOL-INSECTA-PATHOL(64078) S losys terra t 1c Codes: GRAMINEAE(25305): COLEOPTERA(75304); ABSTRACTS OF ENTOMOLOGY(96000) 73074723 PHOSPHINE FUMIGATION OF POLY VINYL CHLORIDE COVERED EARTH WALLED BULK GRAIN STORAGES FULL-SCALE TRIALS USING A SURFACE APPLICATION TECHNIQUE. BANKS H d: STICKA R DIV. ENTOMOL.. CSIRO, P.O. BOX 1700, CANBERRA CITY. A.C.T. 2601 . AUST CSIRO DIV ENTOMOL TECH PAP O (18). 1981. 1-45. Coden: ASEPA Language: ENGL ISH Trials of a phosphine fumigation technique for temporary, PVC[po1yv1nyI chi or 1de]-covered grain storage bunkers of 7000-61,000 tonnes capacity are described. Phosphine was generated from the phosphIde-conta1nIng formulations, Gas-Ex-B, Degesch Plates or Phostoxtn Plates. in blankets or strips. placed on the grain surface below the PVC membrane. The phosphine dispersed rapidly and reached insecticidal levels (> 0.01 g m-3) at all parts of the bulk, except the corners, within 3 days of application. using a dose rate of about 0.75 g PH3 t-1. It took 15-19 days for phosphine levels to become even throughout. Because of the slow gas evolution, speed of distribution, wind effects and the need for extended periods of exposure for Insscl Initial sn inn * R&S 138354 DIALOG FUe5: BIQSIS Previews, 77-83/Jan BA7502 ;RRM2 4021 see- F I 1 e55) (c. BIOSIS 1982) (Item 47 of 858) User 3614 25Jan83 2000 7307 I 2 to ESTROGEN ANTAGONISTS IN CHICK OVIDUCT ANTAGONIST ACTIVITY OF 8 SYNTHETIC TR1 PHENYL ETHYLENE DERIVATIVES AND THEIR INTERACTIONS WITH CYTOPLASMIC AND NUCLEAR ESTROGEN RECEPTORS. SUT.NERLANO R L LUDWIG INSTITUTE FOR CANCER RESEARCH, UNIV. OF SYDNEY, NSW 2006, AUSTRALIA. ENDOCRINOLOGY 109 (6). 1981. 2061-2068. Coden: ENDOA Language: ENGLISH The estrogen agonist and antagonist activities of 8 struetura11y related synthetic compounds (trans- 1 -(4.beta.-d1 - methy t am Inoe thoxypheny1)l,2-d1phenytbut-l-ene {tamox I fen), el s' 1 - ( A . be ta.-d(methyl am 1noethoxypheny1)1,2-d1pheny1bu t- 1-ene (ICI 47,699), .alpha,-(4-pyrro1 1d1noe thoxy)pheny1-4-me thoxy-.- a 1pha.-n1trost11 bene (Cl 628), .a 1pha.-(4-dImethy1 am 1 nopropox - yJpheny1-4-methoxy-.a 1pha.-n1trost11 bene citrate (Cl 680). t-(2-(p-(3,4-df hydro-6-methoxy-2-pheny1 - 1 -naphthy1}phenoxy]et hyl Jpyrrol Id1ne hydrochloride (nafoxldlne), c1s-(3-(p-( 1,2.3,- 4 -1etrahydro-6-methoxy-2-pheny1 - 1-naph thy))phenoxy]1,2-propan ediol (U 23, 4 69), trans- 1 -(p-.beta.-diethylamtnoethoxypheny1 - )1,2-dlphenyl-2-chhoroethylene monocitrate (enc1om1 phene) and els-1-(p-.beta.-diethyl aminoethoxypheny1)1,2-d1pheny1-2-chlor- oethy 1ene monoc1tra t e (zuc1om1 phene)] were tested in the estrogen-withdrawn chick oviduct. No compound demonstrated agonist activity, as assessed by changes In oviduct wet wt, DNA, protoin, and progesterone receptor concentration, when administered for 1 or 3 days at doses ranging from 0.1-100 mg/kg body wt. When 25 mg/kg enclomlphene, tamoxifen. Cl 628, Cl 680. or nafoxtdlne were administered together with 5'mg/kg estrad1o1 benzoa te, a significant Inhibition of estrogen-1nduced increases In oviduct wet wt. DNA, protein and progesterone receptor concentration was observed 24 h later. ICI 47,699, zuclomlphene and U 23, 469 showed no antagonism at this dose. When the cts Isomers (ICI 47,699 and zuclomlphene) were administered at a dose of 25 mg/kg.cntdot.day together with 1 mg/kg .entdot. day estradiol benzoate, they both demonstrated significant antagonist activity 3-4 days later. All 8 ligands were able to displace trltlated estradiol from Its receptor sites (n oviduct cytosol and nuclear extracts. The 5 compounds that were potent antagonists (enclomlphene. Cl 628, Cl 680, tamoxifen and nafoxldlno) had relative binding affinities (estradiol = 100)4) for the nuclear' estrogen receptor ranging from 10-24/1, Within this group, the relative binding affinity was not highly corrolatod with the degree of antagonism. The weak antagonists (ICI 47.699. zuc1om(phono and U 23,469) had comparatively tower affinities for the estrogen receptor, (,e., 1.0-t.5% that of estradiol. Under these experimental conditions', none of the above compounds were estrogenic, and all except U 23,469 showed significant est rogen antagon1sm. Descriptors: ESTRADIOL BENZOATE TAMOXIFEN CIS-1-4-0ETA DI METHYLAMINOETHOXYPHENYL- 1 2-OIPHENYL BUT - 1 -ENE ICI-47699 ALPHA-4 PYRROLIDI NOE THOX Y PHENYL - 4-ME THOXY-ALPHA NITRO ST ILBENE Cl-628 ALPHA-4 DI METHYLAMIN0PR0P0XYPHENYL-4-METHOXY-ALPHA NITRO STILBENE CITRATE CI-680 NAFOXIDINE CIS-3-P-1 234 TETRA HYDRO-6 METH0XY-2-PHENYL-1 -NAPHTHYLPHENOXY 1 2 PROPANEDIOL U-234 69 ENCLOMIPHENE, ZUCLOMIPHENE PROOFSTPPOMP pprcarno onnrciu HORMONE-ORUG DNA Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); RADIATION BIOL-RAOTN, I SOTOP TECH(06504); COMPARATIVE BIOCHEM-GENL STUDIES!* 100lO): 8I0CHEM STUD-GENERAL( 10060 ) ; BTOCilEM STUD-NUCL ACD,PURNS,PYRM( 10062): BIOCHEM STUD-PROTEI NS.PEPTID- ES,AMINO ACD( 10064); BIOCHEM STUD-STEROLS.STEROIDS( 1OOG7) : BIOPHYS-MOLECUL PROP,MACROMOLECC* 10506); REPRODUCT SYST-PHYSI- OL,BIOCHEM(* 16504 ); ENDOCRINE SYST-GONADS,PLACENTA( 17006 ) ; PHARMACOL-ORUG MET A8.METAB ST I MU(22003) : PHARMACOL-ENDOCRINE SYST(*22016); PHARMACOL-REPRODUCT SYST,IMPLANT(*22028) 8!osysternat1c Codes: GALL I FORMES(B5536) DIALOG Flle5: BIOS IS Proviews' -- BA7502;RRM2402tSoo F I Io5S R&s 738355 ^ <c . BinSIS 1902) ( I tom AO of 050) User 3614 2 5 J a 200 1 73070119 SYNTHESIS AND REACTIONS OF DEUTERATED 2 ALKYLIMIN0-3-NITR0S0 OXAZOLIDINES 3 ALKYL-1- 1-2-HYDROXYETHYL-t-NITRDSO UREAS AND RELATED COMPOUNDS AS POSSIBLE INTERMEDIATES IN THE AQUEOUS DECOMPOSITION OF 3 ALKYL-1-2-CHL0R0ETHYL-1-NITROSO UREAS. LOWN d W; CHAUHAN SMS DEP. CHEM.. UNIV. ALBERTA, EDMONTON, ALBERTA. CAN. T6G 2G2. J ORG CHEM 46 (12). 1981. 2479-2489. Codon: dOCEA Language: ENGLISH Decomposition of CCNU-.a 1pha.-d2 (7) [3-cyc1ohexy1 - 1 -n11roso-1 -( i. 1-dIdeuterto-2-ch1oroethy!)urea ] in pH 7.2 phosphate buffer or of CI NO-.aIpha.-d2 (9) [2-(eye 1ohexy1 1mI no}-3-nItro- so-4,4-dldeuterlooxazoltdlne] or CHNU-.a 1pha,-d2 (8) {3 -eye 1ohexy1 - 1 -nItroso- 1 -{1,1-d1deuter1o-2-hydroxyethyt)ureaj with the addition of Ct- gives rise to the same spectrum of products. Including deuterium-free acetaldehyde. a mixture of the 2 deuter 1o-2-ch1oroethanols, 2-hydroxy-2.2-d1deuter 1oethy 1 cyclohexyl carbamates and vinyl chloride containing 1 deuterium. The products were Identified, and the number and position of the deuterium labels were determined. The results ore Interproted In terms of 2 decompos1t1 on pa thways for CCNU [1-(2-chloroethy 1)-3-cyc1ohexy1 - 1-n1trosourea). The 1st decomposition pathway operating for CCNU Is via an Intermediate 2-chioroethaned1azohydrox1de or the equivalent 2-ohloroethy1 cation In agreement with the results of other workers; The 2nd pathway may Involve reversible conversion of 7 to 9 and then ring opening of the latter to 8. Independent decomposition of 8 provides evidence for its conversion to a 1,1-dfdeuterIo-2-hydroxyethaned1azohydrox(de (41). The intermediacy of species 41 may account for the formation of 2-hydroxyethylated nucleosides observed when (2-chtoroethy1)n- Itrosoureas react with DNA. An alternative ring-opening reaction of 9 leads to a 2-hydroxyd1azoethy 1 cyclohexylcarbamate species (37). elimination of which and attack by halide Ion may account for the vinyl halide species formed. Further evidence In support of these competing pathways employing additional specifically deuterated Intermediates Is described and discussed. [(2-Ha 1oethy 1 )n1trosoureas are of clinical value in the treatment of a range of neop1 asms.) Descriptors: 1-2 CHL0R0ETHYL-3-CYCL0HEXYL-1-NITROSO UREA ANTI TUMOR AGENTS Concept Codes: COMPARATIVE BIOCHEM-GENL STUDIES( 10010) ; BIOCHEM METH-GENERAL(* 10050): BIOCHEM STUD-GENERAL{* 10060): BIOPHYS-MOLECUL PROP.MACROMOLECf 10506); PATHOLOGY - THERAPYC 125- 12); PHARMACOL-GENERAL STUDIES(*22002); NEOPLSMS/NEOPL AGNTS-THERAP,AGNT(+24008); CHEMOTHERAPY-GEN STUD.METH.METAB(* - 38502) Language: ITALIAN The results of experimental research In rats. 1 nocu1 a ted ( 1. 2 or 3 times) with PVC [polyvinyl chloride) In th e s.c. t1s sue of a posterior limb. are presented. In 8 of 25 animals malIgnant tumors In various organs were observed f rom 4 0-545 days after treatment. Among these tumors, the most frequent (16%) were carcinomas of the cecum-colon. T he oncogenlc activity of PVC Is demonstrated, and human statls t 1 ca1 data on a higher morbidity and mortality for gastroente r1c neopiasms are confirmed among vinyl chloride-polyvinyl ch1o rlde workers . Descriptors: HUMAN RAT COLON LIMB CARCINOGEN OCCUPAT1ONAL EXPOSURE Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500): BIOCHEM STUD-GENERALC10060): CHORDATE BODY REGNS-EXTREMITIES(- 11318); DIGESTIVE SYST-PATHOLOGY{* 14006); INTEGUMENT SY ST -GENL STUDS,METHSt 18501 ); ROUTES OF IMMUNIZ,INFECT.THERAP(221OO): TOXICOL-GENL/EXP STUDS.METHS( *2 2501 ) : TOXICOL -ENV1RONMNTL. IND USTRY 22506 ) ; NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(* 24007); PUB HEALTH-AOMINISTR.STATI ST ICS(37010): ENVIRON HEALTH-OCCUPATNL HEALTHt *37013) ; ENVIRON HEALTH- A IR.WATR.SL POLLN( * 370 1 5 ) ; EPIDEMIOL-ORGANIC 01S.NEOPLASMS(37054 ) B losystematic Codes: HOMINI DAE<862 1 5) ; MUR I DAE{86375 ) 73069739 EXPERIMENTAL STUDY OF THE ONCOGENIC ACTIVITY OF POLY VINYL CHLORIDE. FRAU G; ZUCCA G; FAA G; DESSY E; FRONGIA N 1ST. DI ANATOMIA E ISTOL. PATOL. DELL' UNI V. DEGLI STIJDI 01 CAGLIARI OSPEDALE S. GIOVANNI DI DIO, VIA OSPEDALE - CAGLIARI. G ITAL MED LAV 3 (1). 1981. 1-4. Coden: G1MLD DIALOG e5: BI05IS Previews 77 R&S 138356 ice F1te 73069645 IN-VITRO METABOLISM OF ACRYLONITRILE TO 2 CYANO ETHYLENE OXIDE REACTION WITH GLUTATHIONE AND IRREVERSIBLE BINDING TO PROTEINS AND NUCLEIC-ACIDS. GUENGERICH F P; GEIGER L E; HOGY L L; WRIGHT P L OEP. BIOCHEM.. VANDERBILT UNIV. SCH. MED.. NASHVILLE. TENN. 37232. CANCER RES CNREA 41 (12 PART 1). 1981. 4925-4933. Coden: Language: ENGLISH The metabolism of the suspected care 1 nogen acrylonitrile was studied using subcellular fractions Isolated from rats and humans. [1-14C]- Irreversible binding of radioactive label from or (2.3 - 14C]acrylon 1tr11e to protein and DNA was enhanced by reduced NADP In the presence of rat 1Iver mlcrosomes or a reconstituted cytochrome P-450 system. During the reduced NADP-dependent reaction, HCN was produced and the hemo of cytochrome P-450 was destroyed. Rat brain mlcrosomes did not produce detectable levels of metabolites. Conclusive evidence of metabol lea 1 1 y mediated binding of aery 1 on 1tr1)e to protein and DNA In human systems was not found. Metabolism was induced In rats by pretreatment of animals with either phenobarbltal or 5,6-benzof1avone. Labeled 2-cyanoethytene oxide was found to bind Irreversibly to calf thymus DNA and microsomal protein. The extent of binding was greater In the case of 2,3 - 14C-1abe1ed than 1 - 14C-1abeled material. The relative Ist-order rate of acrylonitrile binding to calf thymus DNA (n rat liver microsomal systems was 1-2 orders of magnitude less than that for 1,1,2-trlehloroethy 1ene and 3 orders of magnitude less than that for vinyl chloride or vinyl bromide. Rat liver mlcrosomes or a reconst1tuted cytochrome P-450 system catalyzed the mIxed-functIon oxidation of acrylonitrile to 2-cyanoethylene oxide. 2-Cyanoethy 1ene oxide has a half-life of about 2 h In neutral buffer at 37.degree.. This epox1 de was found to serve as a substrate for microsoma 1 epoxide hydrolase. HCN was released during hydrolysis of 2-cyanoethy1ene oxide or reaction of the epoxide with reduced glutathione: HCN release in either case was not stoichiometric with epoxide disappearance. 2-Cyanoethy1ene oxide reacted loss rapidly with reduced glutathione than did acrylonitrile. Rat liver cytosol preparat1ons conta1ned g1utathione 5-transferase activity towards acrylonitrile and greater activity with 2-cyanoethy1ene oxide as a substrate. Cytosol preparations from rat brain and human liver had no detectable glutathione S-transferase activity towards acrylonitrile but did exhibit some activity towards 2-cyanoethylene oxide. These studies establish the basic pathways involved In the metabolism of acrylonitrile and should provide a basis for examination of the relevance of these Individual steps and their roles In bloact1vat1 on and detoxication under more phys1o1oglea 1 s I tua t 1 ons Descriptors: HUMAN RAT CALF THYMUS BRAIN LIVER 1 i 2 TRI CHLORO ETHYLENE VINYL BROMIDE VINYL CHLORIDE CARCINOGEN PHENO BARBITAL 5 6 BENZO FLAVONE GLUTATHIONE S TRANSFERASE EPOXIDE HYDROLASE CYTOCHROME P-450 NADP RADIO LABEL Concept Codes: RADIATION BIOL-RAOTN,ISOTOP TECH(06504): BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURNS,PYRM- (10062): BIOCHEM STUD-PROTEINS,PEPTIDES,AMI NO AC0( 10064); (c. BIOS 15 1982 ) (Item 50 of 858) User 3614 25jan. 2002 BIOCHEM STUD-PORPHVRNS.BILE PIGM( 10065); ENZYMES-PHYS1OLOGI CAL STUDIES{ 10008); METABOLISM-GENL STUD.METAB PAT1IW( I 3002 ): METABDLSSM-PROTNS.PEPTDS.AM ACOS(* 13012): METABOLISM-NUCL ACD.PUR INS.PYRIM(* 130 14); DIGESTIVE SYST-PHYSIOL.BIOCHEM{* 140- 04); ENDOCRINE SYST - THYMUS( 17016): NERVOUS SYST-PHYSTOL,BIOCH- EM(*20504); PHARMACOL-GENERAL STUDIES(22002); TOXICOL-GENL/EXP STUDS,METHSt *22501 ); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007 ); TISS CULTURE-APPARAT.METHS.MEDIA(32500); IN VITRO STUOS-CELLU- LR,SUBCE LL(32600) Blosystemat1c Codes: BOVIDAE{85715); II0MINIDAE(B62 1 5 ) ; MURIDAE(86375) 73068259 ISSUES RELEVANT TO THE ASSESSMENT OF CHEMICALLY INDUCED CHROMOSOME DAMAGE IN-VIVO AND THEIR RELATIONSHIP TO CHEMICAL MUTAGENESIS. ANDER50N D; RICHARDSON C R BRITISH' IND. BIOL. RES. ASSOC., WOODMANSTERNE ROAD. CARSHALTON, SURREY SMS 4DS, ENGL., UK. MUTAT RES 90 (3). 1981. 261-272. Coden: MUREA Language: ENGL ISM Rats were exposed by different routes of administration ( 1nha1 a t1 on. orally and 1.p. ) to k nown mu t agons and t ho 1 r bone-marrow colls sampled at different times to determine the extent of chromosome damage. The mutagens Investigated were ethyl methanesu1fonate, mitomycin C, tr1 methy)phosphate, benzene and vinyl chloride, at single and/or multiple doses (5 consecutive dally). Various categories of chromosome damage were observed In all cases. The extent of damage due to chromosome and chromatid gaps was greater than, and genera 1 1y Increased In parallel with, other categories of damage. Chromosome and chromat1d gaps may be Indicative of toxic phenomena, but such aberrations could be useful as sensitive 1 nd I ca tor s of etiem I ca 1 1 y I nduced genet 1c damage . S 1 ng 1 e exposure Is as effective as multiple exposure In producing chromosome damage: correct sampling time Is necessary to detect this damage. For screening purposes a time course samp ling after a single trea tmeht regime wouId be suitable for detecting the mutagenic potential of a chemical. Descriptors: RAT BONE MARROW CELL ETHYL METHANE SULFONATE MITOMYCIN C TRI METHYL PHOSPHATE BENZENE VINYL CHLORIDE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02 506 ) ; GENETICS/C- YTDGENEr-ANIMAL(*03506) : BIOCHEM STUD-GENERAL( 10060 ) ; DIGESTI VE SYS T-GENL STUDS,METHS(14001); BLOOO/BODY F LOS-GENL STUDS,METHS( 15001); BLOOD/BODY F LDS-BLOOD CELL STUDS(15004); BLOOD/BODY F LDS-LYMPHA T TISS.RES(* 15008): RESPIRATORY SYST-GENL STUD.METHS(16001): DENTAL/ORAL B!OL-GENL STUD.METHSC 19001); PHARMACOL-GENERAL STUD IES('22002); TOXICOL- -GENL/EXP STUDS,METHSt *22501 ); NEOPLSMS/NEOPL AGNTS-THE RAP. AG- NT(24008): CHEMOTHERAPY-GEN STUD.METH.METAB(38502 ) B1osystemat1c Codes: MURIDAE(86375) R&S 138357 DIALOG FUe5: B105IS Previews 77-83/dan bJ/aw;Kni-.UM,v.. F M e55 (c. BIOSIS 1982) (Item 52 of 858) User 3614 25Jan83 2003 73067195 TREATMENT OF THERMOLABILE INSTRUMENTS WITH WATER AFTER COLD STERILIZATION WITH GIGASEPT. HARKE H-P; LINKE M SCHUELKE AND MAYR GMBH. 8EHEJCH FOPSCHUNG UNO ENTWICKLUNG. R08ERT-K0CH-STR. 2, 0-2000 NORDERSTEDT. ZENTRALBL BAKTERIOL MIKROBIOL HYG ABT 1 OR IG B HYG UMWELTHYG KRANKENHAUSHYG ARBEITSHYG PRAEV MED Coden: ZAOMD Language: GERMAN 172 (6). 1981. 520-523. 1 After careful disinfection of polished surfaces of V4A steel, rubber or PVC {polyvinyl chloride] with a 107. Glgasept solution. It Is sufficient to dip the plates Into water for 5 min 1 time only In order to practically clear off all residues. Irregularly shaped parts should be rinsed twice. This 2nd time should last 1 h. or If a shorter dipping time Is desired, the Instrument should be moved. Descriptors: STEEL RUBBER POLY VINYL CHLORIDE Concept Codes: BIOCHEM STUO-GENERAL{ 10060.) ; MINERALSC 10069) ; BIOPHYS-810ENGINE ERING( 10511); EXTERN EFF-TMPERATURE( 10614); EXTERN EFF-COLD{106 16); EXTERN EFF-HOT{106 1 8); TEMPERATURE-GE- NL.METHS{2300 I); PUB HEALTH-DISNFCT,VECT CNT.PEST(*37008): DISINFECTION.OISINFECTANTS.STERL(*39500) 73064712 POWER . CONSIDERATIONS IN EPIDEMIOLOGIC STUDIES OF VINYL CHLORIDE WORKERS. BEAUMONT d d; BRESLOW N E INDUSTRYWIDE STUDIES BRANCH F-8, NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH. CINCINNATI, OH 45226. 4676 COLUMBIA PARKWAY. AM d EPIDEMIOL 114 (5). 1901. 725-734. Language: ENGL ISH Coden: AdEPA Nine retrospective mortality studies of workers exposed to vinyl chloride were reviewed to determine whether differences in their hypo thesIs testing results might be due to differences In statistical power. Where possible, the power of each study was calculated for cancer of the lung, brain and liver. When power was taken Into consideration, the results for liver and brain cancer were consistent with an etlolog1c rote for vinyl chloride. For lung cancer, the data were not consistent with on etlologtc role. In that 2 studies with very high power yielded negative results. Descriptors: MORTALITY HUMAN LUNG CANCER BRAIN CANCER LIVER CANCER Concept Codes: MATHEMATIC BIOL/STAT I5T1C METH(04500); BIOCHEM STUD-GENERAL(10060); PATHOLOGY-COMPARATIVE(12503); PATHOLOGY-NECROSISt12510); DIGESTIVE SYST-PATI (OLOGY(*14006); RESPIRATORY SYST-PATHOLOGY(*16006); NERVOUS SYST-PATHOLOGY(*2 - 0506); TOXICOL-ENVIRONMNTL.INOUSTR{*22506); NEOPLSMS/NEOPL AGNT5-CARCIN0GENS(*24007): PUB HEALTH-ADM INISTR.STAT I ST ICS(* 37010); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); EPIDEMIOL-ORGANIC DIS.NEOPLASMSC*37054) 8 losystematIc Codes: HOMINIDAE{86215) 73060466 MECHANICAL CONTROL OF THE ACTIVITY OF GLUCOSE OXIDASE IMMOBILIZED ON POROUS POLY VINYL CHLORIDE MEMBRANE. I SHI MORI Y; KARUBE I ; SUZUKI S RES. LAB. RESOURCE UT IL I-ZAT ION. TOKYO INST. TECHNOL . . 4259 NAGATSUTA-CHO, MIDORI-KU, YOKOHAMA, 227, JAPAN. BIOT ECHNOL BIOENG BIBI A 23 ( 11). 1981. 2601-2608. Coden: Language: ENGLISH Glucose oxidase (Aspergillus niger] was Immobilized on a porous polyvinylchloride (PVC) membrane. The activity of the glucose oxtdase-PVC membrane decreased when the membrane was mechanically stretched. A linear relationship was observed between the stress and the relative logarithmic activity of the glucose oxtdase-PVC membrane. Apparent Km and maximum velocity (Vm) of the glucose oxldase-PVC membrane under stretched conditions were 1.4 and 0.71 times those without stretching, respectively. The decrease of the membrane activity with stress was reproducible. The glucose oxidase activity of the membrane can be controlled with stress. Descriptors: ASPERGILLUS-NIGER MICHA EL IS CONSTANT STRESS CONTROL Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500); BIOCHEM METH-GENERAL(10050); BIOCHEM STUO-GENERAL(10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO AC0(1O064 ); BIOPHYS-GENE- RAL STUDIES( 10502): BIOPHYS-GENERAL BIOPHYS TECH( 10504 } ; BIOPHYS-MOLECUL PROP,MACROMOLEC(10506); BIOPHYS-MEMBRANE PHENOMENA( 10508); 8 IOPHYS-BIOENGINEERING(* 105 1 1); EXTERN EFF-PHYSI CAL,MECH EFFECTS( 10612): ENZYMES-GEN.COMPAR STUD.COE- NZYMSt 10802 ) : ENZYMES-METHODS (* 10804 ) ; ENZ YME S - CHEM . PHY S I C A l. STUDIES( 10806); MOVEMENT( 12lOO): FOOD/INDUS MICRO-SYN,BI 0ASS, - FERM(*39007); PLANT PHYSIOL-ENZYMES(*51518) 8 losys temat1c Codes: DEUTEROMYCETES(15 500) R&S 138358 DIALOG Flle5: 8I0SIS Prev 1 ews. 77-83/Jan B-, hkm2402 (Sec File55) (c. BIOSIS 1982) (Item 55 of 858) User 3614 25JanB3 2004 73057900 ACUTE HEPATO TOXICITY OF INHALED VINYL CHLORIDE. TATRAI E; UNGVARY G ORSZAGOS MUNKA-ES UZEMEGESZSEGUGYI INTEZET, H-1450 BUDAPEST. NAGYVARAO TER 2., HUNGARY. ACTA MORPHOL ACAD SCI HUNG Coden: AMSHA 29 (2-3). 1981. 221-228. Language: ENGLISH Acute toxicity of vinyl chloride [envt ronmenta 1 pollutant) exposure was studied by morphological methods In 3 spp. (mouse, rat, rabbit). In rats and rabbits exposure to 1500 ppm of vinyl chloride for 24 h did not cause pathological changes. In mice shorter Inhalation (4 and B h) resulted In circulatory changes, while longer exposure (12 and 24 h) caused vasomotor paralysis followed by' characteristic shock; subsequent alteratIons could be seen In the liver and lungs. The acute hepa totox f c 1 ty of vinyl chloride could not be proved. Descriptors: MOUSE RAT RABBIT ENVIRONMENTAL POLLUTANT CIRCULATORY CHANGE VASO MOTOR PARALYSIS SHOCK LUNG ALTERATION Concept Codes: BIOCHEM STUD-GENERAL( 10060>; DIGESTIVE SYST-PATHOLDGY(* 14006); CARDIOVASC SYST-8LD VESS PATHOL(* 1450- 8): RESPIRATORY SYST-PATHOLOGY(*16006); TOXICOL-ENVIRONMNTL, I NDUSTRt*22506); ENVIRON HEALTH-A IR.WATR.SL POLLN{* 37015) 8losystematIc Codes: LEPORI DAE(86040); MURIDAE(86375) 73049943 THE DETERMINATION OF VINYL CHLORIDE IN THE ATMOSPHERE BY MEANS OF GAS CHROMATOGRAPHY AFTER SAMPLING ON ACTIVATED CHARCOAL. KEMKA R; KOLLAR V VUPL, LIMBOVA 14, 809 5B BRATISLAVA. PRAC LEK 33 (5). 1981. 167-170. Coden: PRLFA Language: CZECH The method was elaborated as a means to control short-term and all-shift concentrations of vinyl chloride, whose maximum allowable concentration in Czechoslovakia was recommended to be 10 mg/m3 for the average and 30 mg/m3 for the threshold. Samples of air were takon at a flow rate of 0.03-0.05 1/mln into the tube containing 200 mg activated charcoal GA-1, particle size 0.8-1.25 mm. Vinyl chloride was extracted from the charcoa1 by s ta t ionary elution Into 2 m! of elution agon t (CS2 with CC14 as Internal standard) In which the content remained unchanged for 6 days If kept at -20.degree. C. Tito column temperature was 35.degree. C. length 2 m, diametor 2.5 mm, and was filled with Chromosorb W 80-100 mesh with 3% Carbowax 20 M. The Injection port and flame-ionlzat ton detector (EID) were heated to 200.degree. C. For carrier gas, N was used (flow rate 35 ml/mtn). Samples of 1 .mu.1 containing CC14 were analyzed for internal standard. The relative error of determination of vinyl chloride In the air In the concentration range 53-9506 mg/m3 was between -3.1 and 2.4'/,. The non-quant 1 tat 1 ve stationary elution of vinyl chloride from the activated charcoal must be corrected by a coef f tclent of elution 0.83. Descriptors: MONITORING OCCUPATIONAL HEALTH APPARATUS(01010): BIOCHEM-GASES{ 100 I 2): BIOCHEM METH-GENERAL(- *10050); BIOCHEM STUD-GENERAL( 10060); 8 IOPHYS-GENERAL BIOPHYS TECH( 10504}; MOVEMENT( 12100): TOXI COL -ENVIRONMNTL,IN0USTR( *22- 506) ; ENVIRON HEALTH-OCCUPATNL HEALTHt*3 7013): ENVIRON HEALTH-AIR,WATR.SL P0LLN(*37015) 7 304 8 195 ANGIO SARCOMA OF THE LIVER A CASE. CAULET T: PAYEN L; PINTEAUX A; PLUOT M; DELATTRE J F; LEU1ENEGGER M SERVICE CENTRAL ANATOMIE CYTOL. PATHOL., CHU ROBERT OEBRE . RUE ALEXIS CARREL, 51100 REIMS. ARCH ANAT CYTOL PATHOL AACPO 29 (4). 1981. 239-245. Coden: Language: FRENCH The case of an angiosarcoma of the 1Iver occurring in a 64 yr old diabetic man with fever and a painful abdominal syndrome Is presented. Clinical examination and chest X-rays revealed an hepatomegaly and a large opacity of the upper lobe of the right lung. Ho died 1 mo. later from a massive 1nt ra-ahdomt na1 hemorrhage. A t necropsy the relevant findings were a huge angiosarcoma of the liver with pulmonary and lymph node metastases. The microscopic features were Identified by optical and u1trastruetura1 studies. This case Is compared to other cases of the literature which occurred In the absence of known exposure to care 1nogenIc factors such as thorotrast . arsenic and vinyl chloride (75*/ of the cases) and in conjunction w1th 1ong-term exposure to specific agents. In the present case none of the carcinogenic factors was found In the patient's history. Descriptors: HUMAN LUNG ABDOMEN LYMPH NODE VINYL CHLORIDE THOROTRAST ARSENIC CARCINOGEN DIABETES PAIN METASTASIS HEMORRHAGE X-RAY HEPATOMEGALY Concept Codes: PHOTOGRAPHY-METHS.MATLS.APPARAT(01012 ) ; RADIATION BIOL-RADTN,ISOTOP TECH(06504); BIOCHEM STUD-GENERAL- (10060); M1NERALS( 10069); CHORDATE BODY REGNS-THORAX( 1 1 3 1 2 ) ; CHORDATE BODY REGNS-ABD0MEN( 1 13 14 ) ; PATHOLDGY-DIAGNOSTIC{1250- 4 ) ; PATHOLOGY-NECR0SIS( 12510): ME TABOLISM-CARBOHYDRATES( 13004) ; METABOLISM-METABOLIC D I SORDERS(* 13020): DIGESTIVE SYST-PATHOLOGYt 14006) : CARDIOVASC SYST-BLD VESS PATHOL(* 1 450- B); BLOOO/BODY FLOS - BLO.LYM,RES PATH(* 15006 ) ; BLOOD/BOOY FLDS-LYMPHAT T I SS . RES( 15008); RESPIRATORY SYST-PATHOLOGY(* 160- 06); ENDOCRINE SYST-PANCREAS( 17008); NERVOUS SYST-PHYSIOL.BI 0 - Cl ICM ( 20504 ) ; TOXICOL-GENL/EXP ST UOS . METHS ( 2250 1 ) ; NF.OPLSMS/N- EOPL AGNTS-D1AGNS METH(24001): NFOPLSMS/NEOPl. AGNTS-PATH.CL 1 N- IC(*24004); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(24007) Blosystemat Ic Codes: HOMINIOAE(862 15 ) R&S 1383 DIALOG Ffle5: BIOSIS Previews 77-B3/Jan BA7502:RRM2402(See Flle55) (c. BIOSIS 1982) (Item 58 of 858) User 3614 25Jan83 2005 73047914 ULTRASTRUCTURE OF HEPATIC ANGIO SARCOMA IN RATS INDUCED BY VINYL CHLORIDE. SPIT B J; FERON V J; HENDRIKSEN C F M INST. ClVO-TDXICOL. NUTR. TNO, P.O. BOX 360. 3700 AJ ZEIST NETH. EXP MOL PATHOL 35 (2). 1981. 277-284. Coden: EXMPA Language: ENGLISH The hepatic angiosarcoma studied was from a male Wistar rat exposed to vinyl chloride monomer (VCM) by the oral route for 120 wk. Widened sinusoids linked by large electron-1ucent. spindle-shaped tumor cells and membrane-bound nuclear-free structures were seen In the transitional zone between the tumor mass and the adjacent liver tissue. In areas consisting solely of tumor tissue the tumor cells had a more angular or Irregular shape. The origin of the tumor cells Is discussed In light of the characteristic differences between endothelial cells and Kupffer cells described In the literature. Although an endothelial origin of the tumor cells could not be established unequivocally, 'at present there is little reason to doubt such an origin. Descriptors: CARCINOGEN ENDOTHELIAL ORIGIN SINUSOID SPINDLE SHAPED CELL ORAL ADMINISTRATION Concept Codes: MlCROSCOPY-CYTOLOG,CYTOCHEM TECH(01054); MICROSCOPY-HISTOL.HISTOCHEM TECHt01056); CYTOLOGY/CYTOCHEM-AN IMAL (*02506); BIOCHEM STUD-GENERAL(10060); ANATOMY/HISTOL-MIC RO , ULTRAMI CRSC( 1 1 108 ) ; DIGESTIVE SYST- PATHOLOGY(14 006): CARDIOVASC SYST-8LD VESS PATHOL(*14SOB); BLDOO/BODY FLDS-LYMPHAT TISS,RES(* 15008); DENTAL/ORAL BIOL-GENL STUD.METHSt19001); ROUTES OF IMMUNIZ,INFECT,THERAP{22100); TOXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPL AGNTS-PA- TH,CLIN1C(* 2 4004); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007) BiosystematIc Codes: MURIDAE(86375) 73047869 FOLLOW-UP STUDY ON THE CARCINOGENICITY OF VINYL CHLORIDE AND VINYLIDENE CHLORIDE IN RATS AND MICE TUMOR INCIDENCE AND MORTALITY SUBSEQUENT TO EXPOSURE. HONG C B; WINSTON J M; THORNBURG L P; LEE C C; WOODS J S BATTELLE SEATTLE RESEARCH CENTER, 4000 N.E. 41ST ST.. SEATTLE, WASHINGTON 98105. d TOXICOL ENVIRON HEALTH 7 (6). 1981. 909-924. Coden: JTEHD Language: ENGLISH Carcinogenic and other toxic effects in rats and mice were exam 1ned during a 12-mo. period following exposure to vinyl chloride (VC) or vinyl(dene chloride (VDC). Exposure of male and female mice to 50, 250 or 1000 ppm VC for 6 h/day. 5 days/wk for r, 3 or 6 mo. resulted In Increased numbers of deaths and Increased morI bund 11y at all dose levels during the exposure and postexposure periods as compared with air-exposed controls. Similar observe11ons were made with rats after 1. 3, 6 or 10 mo. exposure to VC. Cumulative tumor Incidence at various organ sites 1ncreased In both species during the postexposure period In' proportion to dose or duration of exposure at higher dose levels. Excent for mammarv nhrH tumors In female mice no significant Increase In cumulative tumor Incidence occurred In either species at 50 ppm VC or 55 ppm VOC regardless of duration of exposure. Exposure to vinyl halides at dose levels 1 over than those that elicit a significant Increase In cancer Incidence during the lifetime of the animal may Increase the risk of early death or morlbundlty from toxic pre- or subcarcI nogenic effects. At dose levels higher than those consistent with the physiological defense or repair capabilities of the cell, ultimate tumor Incidence becomes proportionate to length of exposure and may reflect the number of carcinogenic events elicited during the exposure period. Descriptors: MAMMARY GLAND TUMOR CELL DEFENSE REPAIR DOSE DEPENDENCE EXPOSURE LENGTH ' Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506): BIOCHEM-GAS- ES( 10012): BIOCHEM STUD-GENERAL( 10060); PATHOLOGY-NECROSIS( 1 2- 510); METABOLISM-GENL STUO.METAB PATHW(13002); REPRODUCT SYST-PATH0L0GY(* 16506); TOXICOL-GENL/EXP STUOS.METHS(2250 1 ) : NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007) B losys tematIc Codes: MUR 10AE(86375 ) 73043998 AUTOMATED DETERMINATION OF AMMONIA WITH A POTENTIOMETRIC GAS SENSOR AND FLOWING INTERNAL ELECTROLYTE. FRA TI CELL I Y M; MEYERHOFF M E DEP. CHEM., UNIV. MICHIGAN, ANN ARBOR, MICHIGAN 48109. ANAL CHEM 53 (7). 1981. 992-997. Coden: ANCHA Language: ENGLISH An electrode-based automated method for rapid determination of ammonla-N In the 10-6 to 10-3 mo 1/1 range Is described. The system des Igned utilizes a nove1 tubular flow-through po1y(v1ny1 chlorldel-nonaetIn membrane electrode to sense NH4* formed In a recipient Internal buffer stream as the sample passes through a gas dialysis chamber. Peak potentials observed are logarithmically related to sample ammon 1 a - N concentrations. At least 30 samples/h can be determined with excellent precist on ( . + - . 1 mV SO) for samp 1es .It oreq. 10-4 mol/I. Thorough Investigations regarding the optimization of system variables such as flow rates. diluent reagents, segmentation, etc., are described. Preliminary studies are presented which demonstrate the Immediate application of this system for the determination of ammonia In human serum, plasma and whole blood samples. Descriptors: HUMAN SERUM PLASMA WHOLE BLOOD POLY VINYL CHLORIDE NONACTIN MEMBRANE ELECTRODE Concept Codes: CLIN BIOCHEM-GENL STUD IES(10006); BIOCHEM METH-GENERALI * 10050); BIOCHEM STUD -GENERAL( 10060); BIOPHYS-GE- NERAL BIOPHYS TECH( 10504); BIOPHYS-BIOENGINEERING(* 105 1 1 ) : BLOOD/BODY FLDS-BLOOD,LYMPH STUD{* 15002 ) BtosystematIc Codes: HOMINIDAE(862155 R&S 138360 DIALOG FI1e5: BIOSIS Previews 77-B3/Jan BA7502;RHM2402(See Flle55) (c. BIOSIS 1982) (Item 61 of 858) User 3G14 25jan83 2006 73043590 EVALUATION OF BIO COMPATIBILITY OF POLYMERS FOR THE DEVELOPMENT OF PERITONEAL DIALYSIS CATHETER RAY A R: VERMA K; CHAUDHRY V P CENTRE FOR 8I0MEDICAL ENGINEERING INDIAN INST. OF TECHNOL.. NEW DELHI 110016. INDIAN J MED RES 74 (AUG.). 19BI. 308-3)1. Language: ENGL ISH Coden: IJMRA Two Indigenously obtained polymeric materials (polyvinyl chloride and nylon) were implanted s.c. In rats to test their btocompatIbl1 Ity. The tissue reactions to these materials were evaluated and compared with the commonly used peritoneal dialys1s catheter material. Since nylon material was comparatively safer, dialysis catheter. It may be used for making the peritoneal Descriptors: RAT POLY VINYL CHLORIDE NYLON Concept Codes: BIOPHYS-GENERAL BIOPHYS TECH(10504); BIDPHYS-BIOENGINEERING!*10511): ANATOMY/HISTOL- EXPERIMENTAL( 11104); ANATOMY/HISTOL-SURGERY(*11105); ANATOMY/HISTOL-REGEN,TRANSPLANT(*11107); CIIORDATE BODY REGNS-ABDOMEN(*11314); MOVEMENT(12100}T PATHOLOGY-COMPARATIVE- (12503); PATHOLOGY-THERAPY(*12512); BLOOD/BODY FLDS-GENL STUDS,METHS{* 15001); BLOOD/BODY FLDS-BLOOD,LYMPH STUD{15002); URIN SYST/EXT SECR-GEN STUD.METH(* 15501 ); URIN SYST/EXT SECR-PATHOLOGY(15506); COELOM MEMBRANES.MESENTERIES,ETC(1820- 0); INTEGUMENT SYST-GENL STUDS,METHS(18501): ROUTES OF IMMUNIZ,INFECT,THERAP(22100); IMMUNOL/IMMUNOCHEM-GEN METH(345- 02); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(*34508) B1osystemat1c Codes; MURIDAE(86375) Concept Codes: CYTOLOGY/CYIOCHEM-ANIMAL(0250G); BIOCHEM STUD-GENERAU 10060); BIOCHEM STUD-PROTE I NS.PEPTI 0ES,AMI NO ACD(10064); MINERALS(10069); ENZYMES-PHYSIOLOGICAL STU0!S(*1- 0808); PATHOLOGY-COMPARATIVE( 12 503): PATHOLOGY-INFLAMMATN. INF- LAM DIS( 12508 ); METABOLISM-GENL STUD.MET AB PATHW( 13002); MINERALS! 130 10): META80LISM-PROTNS,PEPTDS.AM ACDS( * 13012) ; RESPIRATORY SYST-GENL STUD.METHS(16001); RESPIRATORY SYST- PA THOLOGY(* 16006); ROUTES OF IMMUNIZ. INFECT.THERAP(2210O) ; TOXICOL-GENL/EXP STUDS,METHS(*22501}: TOXICOL-ENVIRONMNTL. I - NDUSTfl(22506); ENVIRON HEALTH-OCCUPATNL HEALTH(370 1 3 ) B I osys terra t lc Codes: MUR I DAE { 86 375) 73043370 BIOCHEMICAL AND CELLULAR REACTION OF POLY VINYL CHLORIDE PASTE POLYMERS ANO LATEX FOLLOWING INTRA TRACHEAL INSTILLATION INTO RATS TETLEY T D; ROSE F A; RICHARDS R J DEP. BIOCHEM. . UNIV. COLL., CARDIFF CF1 1 XL, WALES. U.K, INFLAMMATION 5 (2). 1981. 137-152. Coden; INFLD Language: ENGLISH Rats were given different doses (0.25-25 mg) of 2 forms of PVC [polyvinylchloride] paste polymers and polystyrene by Intratracheal Instillation and monitored for cellular and blochemleal changes In the 1ung 1avage fluid and rema1n tng lung tissue after 1 and 4 wk of exposure. Changes were observed In free cell morphology, level of pulmonary surfactant and hydrolytic enzyme activities with all 3 compounds .at high concentrations. Some differences In the extent of changes produced per given moss Instilled were noted with different formulations and the relationship between partic1e numbers. surface areas and detergent coatings of samples was discussed. PVC paste polymers and polystyrene cannot be cons 1derpd totally biologically Inert but In comparison with active cytoxlc and Inflammatory minerals such as chrystile asbestos, the extent of their Initial reaction In the lung was relatively weak. Op sr r ln*npe ' niOV?ar!l c *r*ir-Tr>c n n < 'i 8361 DIALOG FlleS: BIOS1S Previews 77-83/dan BA7502;RRM2402{See F11e55) (c. 8I0SIS 19B2) (Item 63 of 858) User 3614 25Jan83 2007 73036B86 CRYO PRESERVED RED BLOOD CELLS FOR PEDIATRIC TRANSFUSION FROZEN STORAGE OF SMALL ALIQUOTS IN POLY VINYL CHLORIDE PLASTIC BAGS VALERI C R; VALERI D A; GRAY A; MELARGNO A d; VECCHIONE J J: DENNIS R C: EMERSON C P NAVAL BLOOD RES. LAB., BOSTON. MASS. TRANSFUSION {PHILA) 21 (5). 1981. 527-536. Coden: TRANA Langudgs: ENGLISH Human nonreJuvenated and rejuvenated red blood cells were prepared for cryopreserva t1 on and subsequent pedI a t r 1 c transfusion. Glycerol was added to the red blood cells In the primary polyvinyl chloride plastic collection bag to achieve a concentration of 40% wt/vol. The red blood cells were concentre ted by cent r1fuga t1 on, and the supernatant glycerol was discarded. Each glycerolfzed unit was divided Into 4 equal a 11 quo ts In the tndtvldua1 600 ml bags of a dry quadruple polyvinyl chloride plastic system, and each aliquot was frozen and stored at -80.degree. C. After thawing, NaC1 solutions were used to wash the aliquots In the IBM Blood Processor 299 1-1 or 2991-2 or the Haemonetics Blood Processor 115. and the washed aliquots were stored In a NaCl glucose phosphate solution at 4.degree. C for 24 h. Freeze-thaw recovery of the red blood cells was about 97%. and freeze-thaw-wash recovery was about 84%. Twenty-four-hour posttransfus 1 on survival values were about 92% for both nonrejuvenated and Indated-rejuvenated red blood cells. Nonrejuvenated red btood cells, those frozen within 3-5 days of collection wlthout biochemical modification, had normal 02 transport function at the time of transfusion: rejuvenated red blood cells, those biochemically treated with PIGPA [pyruvate, Inoslne, glucose, phosphate, adenine and NaCl]. Solution A after 3-5 days of storage at 4.degree. C. had Improved 02 transport function at the time of transfusion. Descriptors: HUMAN GLYCEROL SOOIUM CHLORIDE GLUCOSE PHOSPHATE SOLUTION IBM BLOOD PROCESSOR HAEMONETICS BLOOD PROCESSOR Concept Codes: SIOCHEM-GASES(10012); BIOCHEM STUD-GENERAL( 1- 0060); BIOCHEM STUO-NUCL ACD,PURNS,PYRM( 10062): BIOCHEM STUD-CARBOHYOR.(10068); MINERALS(10069); BIOPHYS-GENERAL BIOPHYS TECH{10504): BI0PHYS-MEMBRANE PHENOMENA(10508); EXTERN EFF-COLO(106 16); M0VEMENT(12100); BLOOD/BODY FLOS-GENL STUDS,MTHS(15001): 8L00D/B0DY FLDS-BLOOD,LYMPH STUD(*15002): BLOOD/BOOY FLOS-BLOOD CELL STU0S(15004): TEMPERATURE-GENL.ME - THS(* 23001); TEMPERATURE-CRYOBIOLOGY(*23004); PEOIATRICS(* 250- DO) Blosystemattc Codes: HOMINIDAE(86215) Language: ENGLISH Cryopreservation of [human] platelets at -80.degree. C with 6% DMSO (d1 mothy1su1fox!do] In PVC [polyvinyl chloride) bags was reevaluated and t compared to cryopreservat1 on In tof 1 on-kapton bags. With platelets stored for > 5 mo., post-thawing recovery was 80 . + -. 9 In the 2 types of bags. Clot retraction, thromboe1 astogram and response to hypotonic shock are 1 dent leal for teflon-kapton and PVC bags and Indicate that the majority of platelets recovered after the freeze-thaw procedure are me tabollcally functlona1 In vitro. Descriptors: HUMAN TEFLON KAPTON CLOT RETRACTION THR0M00 ELASTOGRAM HYPOTONIC SHOCK Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(02508); BIOCHEM STUD-GENERALt10060); EXTERN EFF-COLO(* 10616): BLOOD/BOOY FLDS-GENL STUDS.METHS(* 15001 ): BLOOD/BOOY FLDS-BLOOD CELL STUDS( * 15004) ; TEMPEHATURE-GENL,METHS(*2 3001) : TEMPERATURE - CR YOBIOLOGY (* 2 3004 ) ; IN VITRO ST UOS-CE LLULR . SUBCEL L { 32600 BlosystematIc Codes: HOMINIDAE(86215) 73022388 CRYO PRESERVATION AT MINUS 80 CELSIUS OF PLATELETS IN POLY VINYL CHLORIDE BAGS WITH 6 PERCENT DI METHYL SULFOXIDE LOPEZ M; BARDINET D; FERRER F; ELGHOUZZI M H UNITE U 76. INST!TUT NATIONAL DE LA SANTE ET OE LA RECHERCHE MED.. CENT. NATL. TRANSFUSION SANGUINE. 53 BOULEVARD DIDEROT. 75 012, PARIS. FR. DIALOG R&S 138362 13/dan BA7502;RRM2402(See F(te5s) (c. BIOSIS 1982) (Item 65 of 858} User 3614 25jan83 2008 73018636 RAT HEPATIC VINYL CHLORIDE METABOLITES INDUCE GENE CONVERSION IN THE YEAST STRAIN D 7RA0 IN-VITRO AND IN-VIVO ECKARDT F; MULIAWAN H; DE RUITER N; KAPPUS H INST. BIOL., GESELLSCHAFT STRAHLEN UMWELTFORSCHUNG. INGOLSTAEDTER LANDSTR. ). 0 8042, NEUHERBERG. MUTAT RES 91 (4-5). .1981. 381-390. Language: ENGLISH Coden: MUREA The genetic activity of gaseous vinyl chloride In vitro and In vivo was tested using the gene-conversion system (trp5- 12/1rp5-27 .fwdarw. TRP+) In the yeast (Saccharoaiyces cerevislae) strain 07RAD. To Induce, In vitro. TRP+ convertants with 2.5% gaseous vinyl chloride, a rat liver m1crosoma1 system for me tabolie activation of the vinyl chloride and dividing yeast cells are required. Neither a deficiency In excision repair (rad3) nor In the error-prone repa1r pathway (rad6) Increased the vinyl chloride-Induced conversion frequencies compared with the repair-competent D7RAD strain. When logarithmically growing cells of the D7RAD strain were injected l.v. into male Wtstar rats which Inhaled 1% vinyl chloride In air for 24 h, a significant enhancement of the TRP + conversion frequencies was found compared with that In cells re-isolated from untreated rats. Vinyl chloride metabolites from the metabolizing hepatocytes apparently diffuse into yeast cells. which accumulate In the liver capillaries. The endothelial cells of the liver sinuses, which have hardly any metabolic activity, but which give rise to vinyl chi or 1de-induced hemangiothe11omas (rare type of liver tumor), are apparently transformed by diffusible -metabolites of the procarc1 nogen vinyl chloride. Descriptors: SACCHAROMYCES-CEREVISIAE LIVER SINUS ENDOTHELIAL CELLS HEM ANGIO ENDOTHELIOMA MUTAGEN CARCINOGEN EXCISION REPAIR ERROR PRONE REPAIR HOST MEDIATED ASSAY Concept Cbdes: CYTOLOGY/CYTOCHEM-PLANT{*02504 ); GENET ICS/CY- TOGENET-PLANT(*03504); GENET ICS/CYTOGENET-ANIMAL(*03506) ; BIO- CHEM-GASES( 10012): BIOCHEM STUD-GENERAL{10060): BIOCHEM STUD-NUCL ACD.PURNS,PYRM(10062); BIOCHEM STUD-PROfEI NS,PEPTID - ES.AMINO ACO( 10064); ENZYMES-CHEM.PHYSI CAL STUD1ES( 10806): ENZYMES-PHYSIOLOGICAL STUDIES{10808); MOVEMENT(12100): METABOLISM-GENL STUD,METAB PATHW{* I 3002): METABOLISM:NUCL ACD,PURINS,PYRIM(* 13014); DIGESTIVE SYST-PHYSIOL,BIOCHEM(140- 04); DIGESTIVE SYST-PATHOLOGY{*14006); CARDIOVASC SYST-GENL STUDS.METH5( 14501); ROUTES OF IMMUNIZ,INFECT,THERAP(22100); TOXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPL AGNTS-CA- RCINOGENSf*24007); MICROBIOLOG APPARAT.METHS.MEDIA(32000>; PLANT PHYSIOL-METABOLI$M(5 1519) Blosystemat1c Codes: ASCOMYCETES(15100); MURIQAE(86375) [ Insect] genital la mlcrovlnls which can be closed with PVC stoppers or sealed directly. Descriptors; INSECT Concept Codes: BIOCHEM STUD-GENERAL(* 10060); REPRODUCT SYST-GENL STUDS.METHS(* 16501 ); INVERTS TAXN-INSECTA.GENL( *635 - 72); INVERTS PHYSIOL-INSECTA-GENERAL(*64072) 8losystematic Codes: INSECTA-UNSPECIFI ED(75300) 73014129 SUITABILITY OF VARIOUS AIR SAMPLING METHODS FOR THE EVALUATION OF OCCUPATIONAL EXPOSURE OF WORKERS TO TOXIC SUBSTANCES KRAEVSKI YA; MIL'CHARSKA A; DOBETSKI M INST. MED. IND. TECH. CHEM., LOOZ. POLAND. GIG TR PROF ZABOL Coden: GTPZA O (10). 1980 (RECD. 1981). 17-20. Language: RUSSIAN At a factory manufacturing polyvinyl chloride, average concflntrat1ons of vinyl chloride In the air were estimated by various sampl1ng techniques. Measurement of the average concentration In the environment failed to give adequate Information on the level of occupational exposure. The level of occupational exposure was highly variable (ranging from 1.8-209.5 mg/m3 air) per formed. and depended on the kind of work Descriptors: HUMAN POLY VINYL CHLORIDE Concept Codes: GENERAL FIELD APPARATUS!O101O); BIOCHEM-GASES! 10012): BIOCHEM METH-GENERAL(* 10050): BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH(10504); PHYSIOLOGY-EXERCISE.PHYS THERAP( 120 10); PATHOLOGY-GENERAL STUDIES( 12502); PATHOLOGY-DIAGNOST IC( 12504 ); METABOLISM-GENL STUD,METAB PATHW{13002); TOXI COL-ENVIRONMNTL. INDUSTR(* 22506 }: ENVIRON HEAL I It-OCCUPATNL HEALTH(37013}; ENVIRON HEALTH-A IR.W- ATR,SL POLLN(*37015) Blosystemat1c Codes: HOMINIDAE(B6215) 73017818 GENITALIA VIALS FROM POLY VINYL CHLORIDE VAN DOESBURG P H RIUKSMUSEUM VAN NATUULIJKE HISTORIE,- LEIDEN. ENTOMOL BER (AMST) 40 (12). 1980 (RECD. 1981). Codon: ETBRA Language: ENGLISH Clear PVC [polyvinyl chloride] tube is proposed to 177-178. produce R&S 138363 DIALOG File5: BIOSIS Previews 77-83/dan BA7502;RRM2402(See File55) (c. BIOSIS 1982) (Item 68 of 858) User 3614 25Jan83 2009 73012587 MATERIAL CHARACTERISTICS OF AND RATES OF NITROUS OXIDE DIFFUSION INTO ENDO TRACHEAL TUBE CUFFS SHIMIZU Y; NAM1KI A DEP. ANESTHESIOL., SAPPORO MED. COLL. SAPPORO MED J 50 (4). 1981. 351-360. Coden: SIZSA Language: JAPANESE The character Is11cs of endotracheal tube cuffs made of latex rubber (LR) or polyvinyl chloride (PVC) or silicone rubber (SR) were Investigated In a model tracheal and a vinyl bag filled with N20. and changes In Intra- and lateral cuff pressure In a model trachea were measured. Increases In Intracuff and lateral pressures In LR cuffs were more remarkab1e than those In PVC and SR cuffs. Changes In Intracuff pressure, gas volume, component and concentration In air-inflated cuffs were measured In a vinyl bag filled with N20. N20 diffused Into all cuffs In a concentration and time-related fashion. The rates of N20 diffusion In SR cuffs were very great compared with those In LR and PVC cuffs. SR cufrs were more permeable to*02 and N2 than LR and PVC cuffs. Gas volume In SR cuffs rapidly Increased within a short time and then decreased, though Intracuff pressures did not change from the control values. Gas volume and Introcuff pressure In LR and PVC cuffs increased cont1nuously with time. The overexpans Ion of SR cuffs and the high lateral pressure of LR cuffs may cause trachea 1 obstrue11 on and histological damage to the tracheal wall. Descriptors: MODEL ANIMAL GENERAL ANESTHETIC OXYGEN NITROGEN POLY VINYL CHLORIDE SILICONE RUBBER LATEX RUBBER TRACHEAL OBSTRUCTION HISTOLOGICAL DAMAGE INTRA CUFF PRESSURE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506): BIOCHEM-GA- SES( 10012 ) : BIOCHEM STUD-GENERAL( 10060); BIOPHYS-GENERAL BIOPHYS TECH( 10504); B10PHYS-BIOCYBERNETICS( 10515); EXTERN EFF-PRESSURE( 10606); METABOLISM-GENL STUD.ME T AB PATI1W( 13002): RESPIRATORY SYST-GENL STUD,METHSf* 16001): RESPIRATORY SYST-PATHOLOGY(* 16006); NERVOUS SYST-PHYSIOL,BIOCHEM{* 20504 ) ; PHARMACOL-DRUG METAB,METAB STIMU(*22003); PHARMACOL-NEUROPHAR- MACOLOGYf *22024) Biosystemattc Codes: VERTEBRATA-UNSPECIFIED(05150) 73009320 LARVICIDAL EFFECTIVENESS OF 3 CONTROLLED RELEASE FORMULATIONS OF DURSBAN AND DIMILIN ON CULEX-PIPIENS AND AEDES-AEGYPTI SALEH M S; GAABOUB I A; KASSEM S M I PLANT ` PROTECTION DEP. , FAC. AGRIC. , UNIV. ALEXANDRIA, ALEXANDRIA, EGYPT. J AGRIC SCI 97 (1). 19B1 . 87-96. Coden: JASIA Language: ENGLISH Three plastic formula t1ons of both Oursban and Olmllln wero tested as controlied-release pellets against larvae of C. piplens and A. aegypt1. Each pellet had an Initial concentration of 0.116 .mu.g/1. Results showed that Dlmllln did not appear to g1ve as high percentages of larval mortality as Dursban a 1 though 1n nost cases a clearly delayed Inhibit Ion were ob ta fned In 3-14 {In the case of C. piplens) and 1-12 (In the case of A. aegypt!) days when the 2nd Instar larvae were treated with Dursban formulat(ons. With the Dlmllln formulations no more than 31% (In case of C. piplens) and 24'/. (In case of A. aegypt!) larval mortalities occurred up to 13-14 days until completion of pupation. The results obtained showed that formulation 1 (polyvinyl chloride * dlbutyt phthalate + toxicant) was the most effective of the 3 tested ones, followed by formulations 2 (polyvinyl chloride + dibutyl phthalate + triton X-100 + toxicant) and 3 (polyvinyl chloride + dibutyl phthalate + triton X-100 + ammonium carbonate + citric acid + water + toxicant), respect1ve1y. This was so on the basis both of percentage of larval mortality and time post-treatment. The durations of effectiveness of Dursban pellets were 123, 94 and 86 days for the formulations 1, 2 and 3, respectively. On the basis of number of tests with over go% larval mortal Ity. formulation 2 gave the highest level { 13 tests) followed by formulation 3 (12 tests) and finally formulation 1 (10 tests). ConsIderntIon must be given to the cumulative effect of these factors of activity when using these formulations for control of mosquito larvae. Activity Indices also proved that there was no definite variation In the toxicity of both DDT-suscept1b1e and resistant strains against 1 these formulations. Such results wore obtained with Dlmllln which confirmed that formulation 3 was the most effective one. The durations of effectiveness were about 112-115 (11-67% Inhibition of adult emergence), 111-113 (11-93*4 Inhibition of adult emergence) and 102-113 (12-100*4 Inhibition of adult emergence) days for formu I a tIons 1, 2 and 3, respectively, for the susceptible and resistant lines of C. piplens and A. aegyptl. Descriptors: POLY VINYL CHLORIDE DI BUTYL PHTHALATE TOXICANT MORTALITY DDT Concept Codes: BIOCHEM STUD-GENERAL( 10060) ; PATHOLOGY-NECRO SIS! 125 10 ) : ENDOCRINE SYST-NEUROENDOCRINOLOG( 17020): TOXI COL - -GENL/EXP STUDS,METHS(22501 ): DEVELOPMNTL BIOL-PATHOLOGICAL(2- 5503); PEST CONTRL GENL/PEST ICS/HERB ICS(*54600); ECONOM ENTOMOL-ANIMAL PESTS(* 60012); ECONOM ENT0M0L-BIOLOGICAL CONTRLt*60014); ECONOM ENTOMOL-INTEGRATEO C0NTRL(*60015 ) ; ECONOM ENTOMOL-CHEM PHYS CONTRLt *60016); INVERTS PHYSIOL-INSECTA-PATHOL(64078) Blosystemat1c Codes: DIPTERA{75314); ABSTRACTS OF ENTOMOLOGY(96000) R&S 13836^^ OIALOG FlleS: BIOS1S Previews 77-83/Jan BA7502;RRM2402(See File55) (c. BIOSIS 1982) {Item 70 of 85B) User 36 14 25JanB3 20.10 73002631 CHROMOSOMAL ANALYSIS IN VINYL CHLORIDE EXPOSED WORKERS COMPARISON OF THE STANDARD TECHNIQUE WITH THE SISTER CHROMATID EXCHANGE TECHNIQUE ANOERSON D; RICHARDSON C R; PURCHASE I F H; 0'RIORDAN M L EVANS H J: IMPERIAL CHEMICAL INDUSTRIES LIMITED, CENTRAL TOXICOLOGY LABORATORY, ALDERLY PARK, MACCLESFIELD. CHESHIRE SK10 4TJ. UNITED KINGDOM. MUTAT RES 83 (1). 1981. 137-144. Coden: MUREA Language: ENGLISH A group of 21 workers occupationally exposed to vinyl chloride and 6 controls were examined for the presence of chromosomal aberrations or s1ster-chromat1d exchanges (SCE ] In their peripheral 1ymphocytes. These peop1e comprIsed a 2nd sarrtpl Ing from a group of exposed workers and controls first examined 18 mo. earlier. The vinyl chloride exposed workers showed levels of chromosomal aberrations elevated above those of the controls. but there was only a slight Increase in SCE (per coll or per chromosome} and this increase was not statistically significant. SCE were examined from In vitro cultures of lymphocytes exposed In GO/early G1 and late Gl/early S phase to vinyl chloride, with and without metabolic activation. There was no Increase In SCE in vitro without metabol 1c activation but there was a marked Increase with metabolic activation and this Increase was Independent of coll-cycle phase. The small increases of SCE In workers apparently were not due to the inability of vinyl chloride to induce SCE In human lymphocytes but were probably because of 1ow exposures, and SCE 1 eve 1s couId have returned to norma) relatively quickly after exposure. The analysis of longer-1Ivlng conventional chromosomal aberrations appeared to be a moresens 11We monitor of exposure to vinyl chloride in exposed workers than the estimation of SCE; It should be noted that In a 3rd sampling taken 24 mo. later the exposed workers had chromosomal aberration levels similar to the controls. Descriptors: LYMPHOCYTE CHROMOSOMAL ABERRATION Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(*02503); GENET ICS/CY- TOGENET-HUMAN(*03508); SOCIAL BIOL/HUMAN ECOLOGY(*05500); BIOCHEM STUD-GENERAL{10060); METABOLISM-GENL STUD.ME TAB PATHWt* 13002); BLOOD/BODY FLOS-BLOOO CELL STUDS( 15004); BLOOD/BOOY FLDS-LYMPHAT TISS,RES(15008); T OX I COL -ENVIRONMNT L- ,INDUSTR{*22506 I ; TISS CULTURE-APPARAT,METHS.MEDIA(32500); IN VITRO STUDS-CE LLULR,SUBCELL(32 600); ENVIRON HEALIU-OCCURATNL HEALTH!`37013): ENVIRON HEALTH-A IR,WATR.SL POLLN{* 37015) l! losys tema t 1c Codes: HOMINIOAE ( 862 t S ) 23063791 THE EVALUATION OF MEDICAL PLASTICS IN CONTACT WITH BLOOD. BRUCK S O MED I-TECH INC., SUITE 727-EAST, . 7315 WISCONSIN AVE. . BETHESDA, MO. 20814, USA. BIOMATERIALS 3 (2). 1982. 121-123. Coden: BI MAD Language: ENGLISH Descriptors: HUMAN ANIMAL POLY VINYL CHLORIDE 2 DI ETHYLHEXYL PHTHALATE Concept Codes: BIOCHEM STUD-GENERAL( 10060): BIOPHYS-BIOENGI NE ERING{ * 105111; PATHOLOGY-GENERAL STUOIES( 125021; PATHOLOGY - - COMPARATIVE( 12503); METABOLISM-GENL STUD.META8 PATMW( 13002 ) : BLOOD/BODY FLDS-GENL STUDS.METHSt15001): 8LOOD/BOOY FLDS-BLOOD,LYMPH STUDf 15002); TOXI COL-GENL/EXP STUDS,METHSf- 22501) B losystemat Ic Codes: VERTEBRATA-UNSPECIF1EO(85 150 ) ; H0MIN1DAE(862 15 ) 2306 1496 1 N-6 ETHENO ADENOSINE AND 3 N-4 ETHENO CYTIDINE IN POLY RI80 NUCLEOTIDES LEAD TO TRANSCRIPTIONAL ERRORS AND AMBIGUITY. SPENGLER S J; SINGER B A UNIV. CALIF.. BERKELEY. CALIF. 94720. MEETING ON MECHANISMS OF CHEMICAL CARCINOGENESIS PRESENTED AT THE ICN-UNIVERSITY OF CALIFORNIA AT LOS ANGELES SYMPOSIA ON MOLECULAR AND CELLULAR BIOLOGY, FEB. 22-28, 1981. U SUPRAMOL STRUCT CELL BIOCHEM 0 (SUPPL. 5). 1981. 212. Coden: JSSBD Language: ENGLISH Descriptors: ABSTRACT HUMAN VINYL CHLORIDE CARCINOGEN RNA POLYMERASE MANGANESE Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS,REVW(00520) : GENET ICS/CYTOGENE T- ANT MAL(*03506); BIOCHEM STUD-GENERAL(10060> ; BIOCHEM STUO-NUCL ACO,PURNS.PYRM(10062); BIOCHEM STUD-PROTEINS,PEPT10ES,AMINO ACOt 10064); MINERALS( 10069 ) : REPLICATN,TRANSCRIPTN,TRANSLATN(* 10300) : ENZYMES-PHYSIOLOGICaL STUD1ES(* 10808); TOXICOL-GENL/EXP STUDS,METHS(2250 1 ) ; NEOPLSMS/NEOPL AGNTS-CARC INOGENS(-24007) 8tosystemat1c Codes: HOMINIDAE(86215) 23054464 POLY VINYL CHLORIDE AS A FOOD PACKAGING MATERIAL. PEARSON R B IMPERIAL CHEM. INDUSTRIES, LIMITED, PETROCHEM. AND PLASTICS DIV., PO BOX NUMBER 6. BESSEMER RD,, WELWYN GARDEN CITY, HERTS. GREAT BRITAIN. SYMPOSIUM ON THE CHEMISTRY OF FOOD PACKAGING MATERIALS. JUNE 4, 1981. FOOD CHEM 8 (2). 1982. 85-96. Coden: fOCHO Language: ENGLISH Descriptors: MONOMER MIGRATION BOTTLE FILM CAP SEALING Concept Codes: GENL 810L*SYMPOSIA,PROCDNGS.REVW(00520 ) : BIOCHEM MFTH-GENF.RAU 10050) : BIOCHEM STUD-GENERAL (* 10060) ; 8I0PHYS-GENERAL STUOtES( 10502); BIOPHYS-MOLECUL PROP.MACRQMOL- EC(10506); MOVEMENT{121O0); FOOD TECH-GENL STUDS.METHS(*13502> ; TODD TECH-EVALNS PHYS,CHEM PRDPS(13530); FOOD TECH-PREP,PROCE SSNG.ST ORAGE( 13532 ); TOXICOL-FOOD, RFSIDS.ADO IT,PRESRVf 22502) 138365 DIALOG F11e5 : 81 OS IS Previews 77-83/Jan BA7502;RRM2402(See FIiessj (c. BIOSIS 1982) (Item 74 of 858) User 3614 25janB3 201 1 23050303 ANGIO SARCOMA OF THE LIVER A GROWING PROBLEM?. ANON BR MED J 282 (6263). 1981 (RECD. 1982). BMJOA Language: ENGLISH 504-505. Coden: Descriptors: HUMAN THOROTRAST ARSENIC VINYL CHLORIDE CARCINOGEN CLINICAL FEATURES Concept Codes: 8I0CHEM STUD-GENERAL{10060): MINERALS(10069); DIGESTIVE SY S T-PATHOLOGY{* 14006); CARDIOVASC SYST-8LD VESS PATHOL(*14508); TOXICOL-GENL/EXP STUDS.METHS(22501); TOXICOL-- PHARMACOLOGICAL(2 2504 ); TOXI COL-ENVIRONMNTL, INDUSTR(22506 >: NEOPLSMS/NEOPL AGNTS-PATH.CLINIC(* 24004 ); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(+24007); PUB HEALTH-ADMINI5TR.STATI ST ICS(37- OIO); ENVIRON HEALTH-AIR,WATR.SL POLLN{370 1 5): EPI DEMIOL-ORGA- NIC 0 IS,NEOPLASMS( *37054 ) Blosystemat1c Codes: HOMINIOAE(86215) 23046379 EFFECT OF POLY VINYL CHLORIDE OUST ON THE LUNGS. VERTKIN YU I; NIKONOV A A SANIT.-HYG. MED. INST., LENINGRAD. USSR. GIG TR PROF ZABOL O (7). 1981. 48-49. Coden: GTPZA Language: RUSSIAN Descriptors: NOTE HUMAN RAT PNEUMOCONI OS IS FIBROSIS Concept Codes: BI0CHEM-GA5ES( 10012); BIOCHEM STUD-GENERAL( 1- 0060): BIOCHEM STUD-PROTEINS,PEPTIDES,AMI NO ACD( 10064); PAT1I0L0GY-COMPARATIVE(12503); METABOLISM-GENL STUD.METAB PATHW(13002); MET ABOLISM-PROTNS.PEPTDS.AM ACOS(* 130 12 ) : RESPIRATORY SYST-GENL STUD.METHS(16001): RESPIRATORY SYST-PATHOLOGY(*16006); BONE,JNTS.FASC,CONN/AOIP-PATHOL(* 18006); ROUTES OF IMMUNIZ,IN FECT, THERAP(22100); TOXICOL-ENVIRONMNTL.INDUSTR(*22506): ENVI RON HEALTH-OCCUPATNL HEALTH{*37013); ENVIRON HEALTH-A IR.WATR.- SL POLLN(*37015) Blosystemat1c Codes: HOMINIDAE(86215); MURIDAE(86375) 23038224 . PRE NATAL SUSCEPTIBILITY TO CARCINOGENESIS BY XENOBIOTIC SUBSTANCES INCLUDING VINYL CHLORIDE. RICE J M PERINATAL CARCINOGENESIS SECT., LAB. COMPARATIVE CARCINOGENESIS, NATL. CANCER INST., FORT DETRICK. FREDERICK. MD. 21701. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) ANO STRUCTURAL ANALOGS. BETHESDA, MO.'. USA. MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981' (RECD. 1982). 179-188. Coden: EVHPA Language: ENGL ISH Descriptors: RAT CARCINOGEN ZYMBALS GLAND CARCINOMA NEPHRO BlASTOMA ANGIO SARCOMA MIXED FUNCTION OXIDASE TRANS PLACENTAL ROUTE Concept Code's: BIOCHEM STUD-GENERAL ( 10060) : BIOCHEM STUD IE S{ 108OB); METABOLISM-GENL STUO.METAB PATHW( 13002 ) ; CARDIOVASC SYST-BLD VESS PATHOL( 14508 ) : UR IN SYST/EXT SECR-PATHOLOGY( 15 506) ; REPRODUCT SYST-PHYSIOL.BIOCHEM! 16 504 ) ; ENDOCRINE SYST-GENERAL STUD IE S * 17002): INTEGUMENT SYST-PATHOLOGY(18506): TOXICOL-GENL/EXP STUDS.METHS( *2250 1 ) ; TOXI COL-ENVIRONMNTL. INOUSTR(22506); NEOPLSMS/NEOPL AGNTS*CARC - I NOGENS(*24007) ; DEVELOPMNTL BIOL-EXPERIMENTAL( *2 5504 ) B losystomat1c Codes: MURIOAE(86375 ) 23037125 EFFECT OF FUNGICIDES ON ESTERASE ACTIVITY OF THE FUNGUS ASPERGILLUS-NIGER. ANISIMOV A A: LI NOV IT SKAY A V M; KRAPIVINA E K GORKY STATE UNIV. A PPL BIOCHEM MICROBIOL (ENGL TRANSL PRIKL BIOKHIM MIKK OBIOL) 17 (4 ) . 198 1 (RECO. 1982) . 4 56-45B. Coden: APBMA Language: ENGL ISH Descriptors: MOLD MERTHIOLATE TRILANE CATAPINE POLY VINYL CHLORIDE BIO DEGRADATION OAMAGE PROTECTION Concept Codes: BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-PROTEI NS.PEPTIDES.AMINO ACO( 1006 4); ENZYMES-PHYSIOLOGICAL STUDIESC*10808) ; METABOLISM-GENL STUD.METAB PATHW(* 13002}: FOOD/INDUS MICRO-BIQDEGRAO,DETER(*39006); PLANT PHYSIOL-ENZYM- ES(*5 1 5 1 8); PLANT PHYSIOL-METABOLISM(* 5 1 5 1 9 ) ; PEST CONTRL GENL/PESTICS/HERB ICS(*54 600) B losystemat1c Codes: DEUTEROMYCETES(15 500); ABSTRACTS OF MYCOLOGY(95000) 23036538 VINYL CHLORIDE INHALATION TERATOLOGY STUDY IN MICE RATS AND RABBITS. JOHN J A: SMITH F A: SCHWETZ B A TOXICOL. RES. LAB,, HEALTH AND ENVIRON. SCI. USA, DOW CHEMICAL USA, MIDLAND. MICH. 48640. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER. POLY(VINY L CHLORIDE) AND STRUCTURAL ANALOGS. BETHESDA. MD., USA. MAR. 20*21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECD. 1982). 171-178. Coden: EVHPA Language: ENGLISH OescrIptors: ENVIRONMENTAL POLLUTANT OCCUPATIONAL HAZARD ETHANOL Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00520) : BIOCHEM STUD-GENERAL(10060): RESPIRATORY SYST-GENL STUD.METHSf16001): ROUTES OF IMMUNIZ.INFECT.THERAP(22100 ) : TOXICOL-ENVIRONMNTL,INDUSTR(*22506); DEVELOPMNTL BIOL-EXPER TERATOL< *25554 ) ; ENVIRON HEALTH-OCCUPATNL HEALTH{ * 37013 ) : ENVIRON HEALTH-AIR,WATR,SL POLLN(* 37015) Btosystemat1c Codes: LEPORIDAE{86040): MUR I DAE(86375) DIALOG FMe5: BIOSIS Prev lews.77-83/dan BA7502 ; RRM2402 ( See Flle55) (c. R8tS 138366 iy82) (Item 79 of 858) User 3614 25Jan83 2012 23034 2 4 8 ANGIO SARCOMA OF THE LIVER' A SIGNAL LESION OF VINYL CHLORIDE EXPOSURE. VI ANNA N J: BRADY d; HARPER P BUREAU ENVIRONMENTAL EPIDEMIOL., N.Y. STATE DEP. HEALTH. TOWER BUILDING, EMPIRE STATE HEALTH PLAZA. ALBANY, N.Y. (2237. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS, 8 E THE SOA, MD. , USA, MAR. 20-21, 1900. ENVIRON HEALTH PERSPECT 41 (0). 1901 (RECO. 1982). 207-210. Coden: EVHPA Language: ENGLISH Descriptors: HUMAN CARCINOGEN OCCUPATIONAL HAZARD Concept Codes: GENL 81OL-SYMPOSIA.PROCDNGS.REVW(00520); BIOCHEM STUD-GENERAL( 10060) : DIGESTIVE S Y ST - PATHOLOGY ( * 1 4006 ) ; CARD IOVA SC SYS r-BLD VESS PATHOL(* 14500): TOXICOL-ENVIRONMNT L. - INDUSTRI*22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS{*24 007); ENVIRON HE A LTH-OCCUPA TNL HEALTH(*37013}; ENVIRON HEALTH-A IR.W- ATR.SL POLLN(37015); EPI DEMIDL-ORGANIC 0 IS.NEOPLASMS!* 37054) B losys tenna t (c Codes: HOMINI DAE ( 862 15 ) 23034247 EXCESS LUNG CANCER RISK IN A SYNTHETIC CHEMICALS PLANT. WAXWEILER R d; SMITH A H; FALK H; TYROLER H A INDUSTRY-WIDE STUDIES BRANCH, DIV. SURVEILLANCE. HAZARD EVALUATIONS FIELD STUDIES, NATL. INST. OCCUPATIONAL SAFETY AND HEALTH. 4676 COLUMBIA PARKWAY. CINCINNATI. OHIO 45226. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) ANO STRUCTURAL ANALOGS. BETHESDA. MD., USA. MAR. 20-21. 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECO. 1982). 159-166. Coden: EVHPA Language: ENGLISH Descriptors: HUMAN POLY VINYL CHLORIDE CARCINOGEN UNDIFFERENTIATED LUNG CANCER ADENO CARCINOMA Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00520): BIOCHEM STUD-GENERAL!10060): TOXICOL-ENVIRONMNTL.INDUSTR(*225- 06): NEOPL SMS/NEOPL AGNTS-CARCI NOGENS!*24007); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-A IR,WATR,SL POLLNf37015); EPI DEMIOL-ORGANIC 01S.NEOPLASMS!*37054) B1osystematic Codes: HOMINIDAE(86215) SYSTEM TUMORS OCCUPATIONAL HAZARD Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(005 20 ) ; BIOCHEM STUD-GENERAL!10060); PATHOLOGY-NECROSIS(12510}; DIGESTIVE SYST-PATHOLOGY!* 14006); CAROIOVASC SYST-HEART PATHOLOGY!* 14506} ; TOXI COL-ENVIRONMNTL.INOUSTR(22506 ) ; NFOPL- SMS/NEGPL AGNTS-CARCINOGENS!*24007); PUB t IEALTH-AOMINISTR,STA TIST ICS! *37010) ; ENVIRON HEALTH-DCCUPATNL HEALTH(* 37013) ; ENVIRON HEALTH-AIR,WATR,SL POLLNf 37015) ; EPIDEM 1OL-ORGANIC DIS.NEOPLASMS!*37054) B losys terra t 1c Codes : HOMI NI OA E ( 862 15 ) 23034245 THE BRITISH UK HEPATIC ANGIO SARCOMA REGISTER. BAXTER P J CHRONIC DIS. DIV., SPECIAL STUDIES BRANCH. CENTER DIS. CONTROL, ATLANTA, GA. 30333. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER. POLY(VI NY L CHLORIDE) ANO STRUCTURAL ANALOGS, BETHESDA. MD., USA. MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECO. 1982). 115-116. Codon: EVHPA Language: ENGL ISH Descriptors: HUMAN VINYL CHLORIDE THOROTRAST CARCINOGEN RADIO DIAGNOSIS OCCUPATIONAL HAZARD Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520): RADIATION BIOL-RAOTN,ISOTOP TECH(06504); BIOCHEM STUO-GENERAL- ( 10060); PATHOLOGY-DIAGNOSTIC! 12504 ); DIGESTIVE SYST -PATHOLOG- Y(* 14 006); CARDIOVASC SYST-BLD VESS PATHOL(* 14508): TOXICOL-PHARMACOLOGICAL!*22504); TOXICOL-ENVIRONMNTL.INDUSTRf*22506): NEOPLSMS/NEOPL AGNTS-CAR CINOGENS (24007 ); PUB HEALTH-ADMINISTR,STATIST ICS! '37010 ) : ENVIRON HEALTH-DCCUPATNL HEALTH{*37013) ; ENVIRON HEALTH-A 1R,W- ATR.SL POLLN(37015); EPIDEMI 0L-ORGANIC 0 IS,NEOPLASMS( 37054 } Blosystematte Codes: HOMINIDAE(B6215) 23034246 MORTALITY AND CANCER RATES AMONG WORKERS IN THE SWEDISH POLY VINYL CHLORIDE PROCESSING INDUSTRY. MOLINA G; HOLMBERG B; ELOFSSON S; HOLMLUND L; MOOSING R; WESTERHOLM .P OCCUPATIONAL TOXICOL. UNIT. OEP. OCCUPATIONAL MED., LABOR MED. DIV., DEP. OCCUPATIONAL SAFETY. BOX 100, 26 STOCKHOLM, SWED . CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY!VINYL CHLORIDE) AND STRUCTURAL ANALOGS, BETHESDA, MD., USA, MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECD. 1982). 145-152. Coden: EVHPA Language: ENGL ISH DIALOG FI 1e5: BIOSI5 Previews 77-83/Uan 8A 7 502:RRM2 4 03{See F 11e55 } (c. BIOS!! R8.S 138367 ___ uteri 83 of 858) User 3614 25]an83 20 13 23034244 EPIDEMIOLOGIC STUDY OF VINYL CHLORIDE WORKERS MORTALITY THROUGH DEC. 31 1972. COOPER W C 2150 SHATTUCK AVE.. SUITE 401. BERKELEY, CALIF. 94704. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS. BETHESOA. MD.. USA, MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECD. 1982). Language: ENGLISH 101-106. Coden: EVHPA Descriptors: HUMAN RESPIRATORY TRACT MALIGNANCY DIGESTIVE TRACT MALIGNANCY BRAIN NEOPLASM USA Concept Codes: GENL BIOL -SYMPOSI A.PROCDNGS.REVW(005 20): SOCIAL BIOL/HUMAN ECOLOGY{05500): BIOCHEM STUD-GNERAL(10060): PATHOLOGY-NECROSIS!12510); DIGESTIVE SYST-PATHOLOGY{*14006); RESPIRATORY SYST-PATHOLOGY(*16006); NERVOUS SYST-PATHOLOGY(* 2- 0506): T OX I COL-E NVIRONMNT L,INDUSTR(* 2 2506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); PUB HEALTH-ADMINISTR,STATI ST ICS(37 - OIO): ENVIRON HEALTH-OCCUPATNL HEALTH!37013); EPI DEMIOL-ORGANIC DIS,NEOPLASMS!*37054) Biosystemat1c Codes: HOMINIDAE(86215) 23034243 REVIEW OF EPIDEMIOLOGIC STUDY RESULTS OF VINYL CHLORIDE RELATED COMPOUNDS. APFELOORF R: INFANTE P F OFFICE CARCINOGEN IDENTIFICATION CLASSIFICATION. HEALTH STANDARDS PROGRAMS, OCCUPATIONAL SAFETY HEALTH ADM., U.S. DEP. LABOR, WASHINGTON. D.C. 20210. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER. POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS, BETHESOA, MD.. USA, MAR. 20-21. 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECD. 1982). 221-226. Coden: EVHPA Language: ENGLISH Descriptors: HUMAN VINYLIDENE CHLORIDE TRI CHLORO ETHYLENE PER CHLORO ETHYLENE CARBON TETRA CHLORIDE ETHYLENE DI BROMIDE EPI CHLOROHYDRIN CARCINOGENIC RISK MORTALITY Concept Codes: GENL .BIOL-SYMPOSI A.PROCDNGS,REVW(O0520); BIOCHEM STUD-GENERAL!10060); PATHOLOGY-NECROSIS(12510); TOXICOL -ENVIRONMNTL,INDUSTR{+22506); NEOPLSMS/NEOPL AGNTS-CAR- CI NOGENS!*24007); EPIDEMIOL-ORGANIC 0 IS.NEOPLASMS(*37054) Btosystemattc Codes: HOMINIDAE(86215) Descriptors: HUMAN SMOKING AGE Concept Codes: GENL B1OL-SYMPOSI A,PROCDNGS.REVW(00520 ) ; SOCIAL BIOL/HUMAN ECOLOGY(05500); BEHAVIOR BIOL-HUMAN BEHAVIOR!*07004); BIOCHEM STUO-GENERAL(10060): RESPIRATORV SYST-PATHOLOGY!* 16006); PSYCHI ATRY-ADDICTION(INC SMOKNG){* 210- 04); TOXICOL-GENL/EXP STUDS.METHS(22501); TOXI COL-ENVIRONMNTL- . I NDUSTR!* 2 2 506}; OEVELOPMNTL BIOL-GEN MQRPHGENSIS{*2 5508 ) ; ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013); EPIDEMIOL-ORGAN IC CIS.NEOPLASMS!*37054); PLANT PHYSIOL-CHEM CONSTITUENTS(5 1 522 ) : AGRONOMY-TOBACCO CR0PS(52512) B IosystematIc Codes: SOLANACEAE(26775); HOMIN[DAE(862 15 ) 23034241 EPIDEMIOLOGY OF HEPATIC ANGIO SARCOMA IN THE USA 1964-1974, FALK H: HERBERT 0; CROWLEY S: ISHAK K G; THOMAS L B; POPPER H; CALDWELL G G CHRONIC DIS. DIV.. CENT. ENVIRON. HEALTH, PUBLIC HEALTH SERV. . U.S. DEP. HEALTH HUMAN SERV.. ATLANTA. GA. 30333. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIOE MONOMER. POL Y(VI NY L CHLORIDE) AND STRUCTURAL ANALOGS, BETHESOA. MD.. USA, MAR. 20-21, 19B0. ENVIRON HEALTH PERSPECI 41 (0). U 90 1 (RECD. 1982). 107-114. Coden: EVHPA Language: ENGLISH Descriptors: HUMAN ANDROGEN ANABOLIC STEROID TREATMENT SEX DIFFERENCE ARSENIC POLY VINYL CHLORIDE EXPOSURE Concept Codes: GENL 8IOL-SYMPOSIA.PROCDNGS.REVW(00520): GENETICS/CYTOGENET-SEX DIFFERENC(*0351O): SOCIAL BIOL/HUMAN ECOLOGY!05500): BIOCHEM STUD-GENERAL(10060}; BIOCHEM STUD-STEROLS,STEROIDS! 10067); PATHOLOGY - THERAPY{* 1 25 1 2 ) ; DIGE STIVE SYST-PATHOLOGY(* 14006); CAROIOVASC SYST-BLD VESS PATHOL!* 14508); ENOOCRINE SYST-GONADS.PLACENTA(* 17006) ; TOXI COL-PHARMACOLOGICAL! *22504 ) ; TOXICOL-ENVIRONMNTL,INOUSTR!*22506); ENVIRON HEALTH-OCCUPATNL HEALTH!*37013); EPIDEMIOL-ORGANIC OIS,NEOPLASMS(*37054) B I osystemat1c Codes: HOMINIDAE(86215) 23034242 EPIDEMIOLOGICAL STUDY OF PNEUMOCONIOSIS IN THE ITALIAN POLY VINYL CHLORIDE INDUSTRY. MA5TRANGEL0 G; SAIA B; MARCER G; PIAZZA G 1ST. MED. ' LAVORD, UNIV. STUDI PADOVA, VIA FACCIOLATI 71. PADUA, ITALY. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS. BETHESOA, MO.. USA, MAR.'20-21, 1980. ENVIRON HEALTH PERSPECT 4 1 (0). 198 1 (RECD. 1982) . 153- 158. Coden: EVHPA | PMC:i T R&S 138368 DIALOG File5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(Soe Ftle55) (c. BIOSIS 1982) (Item 87 of 858) User 3614 25Jan83 2014 23032 A3 t EFFECTS OF AGING ON THE INDUCTION OF ANGIO SARCOMA. GROTH D H; COATE W 8; ULLAND B M; HORNUNG R W DIV. BIOMED. BEHAV. SCI., NATL. INST. OCCUP. SAF. HEALTH. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIOE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS, BETHESDA, MO., USA, MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 {O). 1981 (RECD. 1982). 53-58. Coden: EVHPA Language : ENGLISH Descriptors: RAT VINYL CHLORIOE CARCINOGEN LIVER LUNG METASTASES SEX Concept Codes: GENL BIOL-SYMPOSI A.PROCDMGS.REVW(005201: GENETICS/CYTOGENET-SEX DIFFERENC(03510); BIOCHEM STUO-GENERAL- (10060); DIGESTIVE SYST-PATHOLOGY{* 14006 ) ; CARDIOVASC SYST-BLO VESS PATHOL(* 14 508) ; RESPIRATORY SYST-PATHOLOGY(* 16006); TOXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPL AGNTS-CA- RCINOGENS(*24007): GERONTDLOGY(*24500) B 1 osys terna t 1 c Codes : MUR I DAE ( 8 6375 ) 23032430 NEOPLASTIC AND NONNEOPLASTIC EFFECTS OF VINYL CHLORIDE IN MOUSE LUNG. SUZUKI Y ENVIRON. SCI. LAB., DEP. COMMUNITY MEO., MT. SINAI SCH. MED. CITY UNIV. N.Y., ONE GUSTAVE LEVY PL.. NEW YORK, N.Y. USA . 10029. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIOE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS. BETHESDA. MD., USA. MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECD. 1982). 31-52. Language: ENGLISH Descr Iptors: ALVEOLOGENIC TUMOR HISTOLOGY ULTRASTRUCTURE Coden: EVHPA HYPERPLASIA INFLAMMATION Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00520): MICRQSCOPY-HISTOL.HISTOCHEM TECH(01056); ELECTRON MICROSCOPY(- 01058); BIOCHEM STUO-GENERAL( 10060); ANATOMY/MISTOL-MICRO.ULT- RAMICRSC(*11108); PATHOLOGY-INFLAMMATN.INFLAM DIS(* 12508 ) ; RESPIRATORY SYST-PATHOLOGY( 16006); NEOPLSMS/NEOPL AGNTS-CARC- INOGENS(*24007) BIosystemot1c Codes : MUR I DAE(0 6375) Concept Codes: GENL BIOL-SYMPOSI A,pROCDNGS.REVW(00520): BIOCHEM STUD-GENERALC 100G0); DIGESTIVE SYST-PATHOLOGY( 14006 ) ; CARDIOVASC SYST-Bl.D VESS PATHOL { 1 4 508 ) : UR IN SYST/EXT SECR- PATHOLOGY(* 15506); REPRODUCT SYST-PATHQLOGY(*16506); ENDOCRINE SYST-GENERAL STUDIES( I 7002); INTEGUMENT SYST-PATHOL- OGY(* 18506); NERVOUS SYST-PATHOLOGY(* 20506) : TOXICOL-GENL/EXP STUDS.METHS( *22501 ): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007 ) Blosystemat1c Codes: CRICETI DAE(86310): MUR I DAE<86375) 23032428 OBSERVATIONS OF THE SITE SPECIFIC CARCINOGENICITY OF VINYL CHLORIDE TO HUMANS. INFANTE P F HEALTH STANDARDS PROGRAMS, OCCUP. SAF. HEALTH ADM. . WASHINGTON. D.C. 20210, USA. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIOE MONOMER. POLYCVINYL CHLORIDE) AND STRUCTURAL ANALOGS, BETHESDA, MD,, USA, MAR, 20-21. 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECD. 1982). 89-94. Coden: EVHPA Language: ENGLISH Descriptors: LIVER CANCER LUNG CANCER CENTRAL NERVOUS SYSTEM cancer Lymphatic cancer leukemia occupational hazard Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520): BIOCHEM STUD-GENERAL( 10060): DIGESTIVE SYST-PATHOLOGY(*14006 ) ; BLOOD/BOOY FLDS-BLO,LYM,RES PATH(t5006); BLOOO/BODY F LOS -LYMPHAT TISS . RES( 15008); RESPIRATORY SYST-PATHOLOGY(* 1 60- 06); NERVOUS SYST-PATHOLOGY(*20506}; TOXI COL-ENVIRONMNTL. INDU- STR{*22506): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007 ) ; NEOPLSMS/NEOPL AGNTS-BLOOD,RES(*24010): ENVIRON HEALTH-OCCUPA - TNL HEALTH(*37013); ENVI RON HEALTH-A IR,WATR,SL POLLN{370 1 5 } ; EPIDEMIOL-ORGANIC DIS.NEOPLASMS(*37054 ) B1osystematIc Codes: HOMINIDAE(86215> 23032429 CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE MONOMER A MODEL OF RISK ASSESSMENT ON AN EXPERIMENTAL BASIS, MALI ONI C; LEFEMINE G: CILIBERTI A; CUTTI G; CARRE ITI D INS r. ONCOL. TUMOR CENT. , BOLOGNA, ITALY. CONFERENCE 'TO REEVALUATE THE TOXICITY OF VINYL CHLORIOE MONOMER, POLYIVINYL ' CHLORIDE) AND STRUCTURAL ANALOGS, BETHESDA, MD.. USA, MAR. 20*21, 1900.' ENVIRON HEALTH PERSPECT 41 (O). 1981 (RECD. 1982). 3-30. Coden: EVHPA Language: ENGLISH Descriptors: RAT MOUSE HAMSTER LIVER ANGIO SARCOMA ZYMBAL GLAND CARCINOMA FORE STOMACH PAPILLOMA ACANTHOMA MAMMARY TUMOR MCOMrn nt A fTOH* * f >- P < r* r> . T*- *-* * t n>< * R&S 138369 DIALOG flle5: BIOSIS Prev1ews. 77-83/dan BA7502;RRM2402{See Flle55j (c. BIOSIS 1982) (Item 91 of 858) User 3614 25jan83 2015 23032 419 .EFFECT OF ETHANOL ON VINYL CHLORIDE CARCINOGENESIS. RADIKE H J; STEMMER K L; BINGHAM E UNIV. CINCINNATI MED. CENT., DEP. ENVIRON. HEALTH. KETTERING LAB.. 3223 EOEN AVE, CINCINNATI. OHIO 45267 . CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER. POLY(VINY L CHLORIDE) AND STRUCTURAL ANALOGS. BETHESDA, MD., USA, MAR. 20-21, 1900. ENVIRON HEALTH PERSPECT 4t (O). 1981 (RECD. 1982). 59-62. Coden: EVHPA Language: ENGL ISH DescrIptors: RAT LIVER ANGIO SARCOMA HEPATO CELLULAR CARCINOMA LYMPHO SARCOMA ENDOCRINE TUMORS Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520): BIOCHEM STUD-GENERAL( 10060); DIGESTIVE SYST - PATHOLOGY(* 14006); CA RDI OVA SC SYST-8LD VESS PATHOL{* 14508): BLOOO/BODY FLDS-BLD,LYM.RES PATH( 15006); BLOOD/BODY F L DS-L YMPHA T TISS.RESt 1500B): ENDOCRINE SYST-GENERAL STUDIES{ * 17002): TDXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPL AGNTS-CA- RCINOGENS(*24007); NEOPLSMS/NEOPL AGNTS-BLOOD.RES(24010) Blosystemat ic Codes: MUR I DAE(86375) 23032418 REVIEW OF EXPERIMENTAL CARCINOGENESIS BY COMPOUNDS RELATED TO VINYL CHLORIDE. CHU K C; MILMAN H A NATL. CANCER INST., BETHESDA, MD. 20205. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS. BETHESDA. MD., USA, MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (O). 1901 (RECO. 1982). 211-220. Language: ENGL 1SH Coden: EVHPA Descriptors: MOUSE RAT VINYLIDENE CHLORIDE TRI CHLORO ETHYLENE PER CHLORO ETHYLENE DI CHLORO ETHANE DI BROMO ETHANE EPI CHLOROHYDRIN CARCINOGEN FORE STOMACH TUMOR LIVER HEM ANGIO SARCOMA HEPATO CELLULAR CARCINOMA KIDNEY TUMOR UTERINE TUMOR MAMMARY GLANO TUMOR FIBROMA LUNG TUMOR Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS,REVW(00520); COMPARATIVE' BIOCHEM-GENL STUDIES( 10010); BIOCHEM STUD-GENERAL- (10060): DIGESTIVE SYST-PATHOLOGY{*14006); CARDIOVASC SYST-BLD VESS PATHOL{14508): URIN SYST/EXT SECR-PATHOLOGY(* 15506); RESPIRATORY SYST-PATHOLOGY(* 16006); BONE.dNTS.FASC.CONN/AOIP-- PATHOLt* 18006); TOXI COL-GENL/EXP STUOS,MET1 IS{*22501): NEOPLSM- S/NEOPL AGNTS-CARCINOGENS(*24007) B1osystemat1c Codes: MURIDAE(86375) 230324 1 7 CANCER INDUCTION FOLLOWING SINGLE AND MULTIPLE EXPOSURES TO A CONSTANT AMOUNT OF VINYL CHLORIDE MONOMER. HEHIR R M; MCNAMARA B P; MCLAUGHLIN J OR; WILLI GAN D A; BIERBOWER G; HARDI STY d F U.S. CONSUMER PRODUCT SAFETY COMMISSION, WESTWOOD TOWERS BUILDING, ROOM 738, 5401 WEST BLVD. . WASHINGTON. D.C. 20207. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE BETHESDA, MO.. USA. MAR. 20-21. 1900. ENVIRON HEALTH PERSPECT 41 (O). 1981 (RECO. 19B2). 63-72. Language: ENGLISH Coden: EVHPA Descriptors: CARCINOMA RAT MOUSE CARCINOGEN PULMONARY ADENOMA Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.BEVW(00520) : BIOCHEM STUO-GENERAL( 10060): RESPIRATORY SYST-PATHOLOGY( * 1 600 - 6); TOXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPL AGNTS-CARCINOGENSt*24007) B losystemat1c Codes: MUR I DAE(86375) 2 30313 BI MUTAGENICITY STUDIES OF VINYL CHLORIDE. FABRICANT d 0; LEGATOR M S DEP. PREVENTIVE MED. COMMUNITY HEALTH, DIV. ENVIRON. TOXICOL.. UNIV, TEX. MED. BRANCH. GALVESTON. TEX. 77550. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS, BETHESDA. MD., USA, MAR. 20-21. 1980. ENVIRON HEALTH PERSPECT 41 (O). 198! (RECD. 1982). 189-194. Coden: EVHPA Language: ENGL ISH Descriptors: HUMAN EUKARYOTE PROKARYOTE SOMATIC MUTATION GERMINAL EFFECT Concept Codes: GENL BIOL-SYMPOSIA,PROCONGS.REVW(00520): GENETICS/CYTDGENET-HUMAN(*03 508): BIOCHEM STUD - GENERAL( 10060): REPRODUCT SYST-GENL STUDS.METHS(16501); REPROOUCT SYST-PATHOLOGY(* 16506): TOXICOL-GENL/EXP STUDS.METHS(*2250 1 >: IN VITRO STUOS-CELLULR.SUBCELL(32600) B losystemat1c Codes: ORGANI SMS-UNSPECIFIE0(00500): MOM INI DA - E(862 15) 23029934 AN IN-VIVO MODEL TO ASSESS BIO MATERIAL THROMBO RESISTANCE. RODVIEN R; ROBINSON d: LITWAK P; MITCHELL R R INST. MED. SCI.. SAN FRANCISCO. CALIF. 8TH INTERNATIONAL CONGRESS DN THROMBOSIS AND HEMOSTASIS, dULY 13-17. 1981. Ti IROMB HAEMOSTASIS 4 6 ( 1) . 1981. 100. Coden: THHAD Language: ENGLISH Descriptors: ABSTRACT GOAT POLY VINYL CHLORIDE CATHETER POLY ETHYLENE CATHETER TEFLON CATHETER INDIUM-111 LABELED PLATELE1S Concept Cories : GENL B IOL -SYMPOS I A . PROCDNGS . RE VW ( 00520) : CYTOLOGY/CYTOCHEM-ANIMAL(02506); RADIATION BIOL-RAOTN.ISOTOP TECH(*06504); BIOPHYS-BIOENGINEERING(*10511); PHYSIOLOGY-COMP- ARATIVE{ 12003); PHYSIOLOGY-METHODS( 12006) ; CARDIOVASC SYST-GENL STUOS.METHS(* 14 501 ) ; CARDIOVASC SYST-BLD VESS PATHOLt* 14508); BLOOD/BODY FLOS-BLOOD.LYMPH STUD( 1 5002 ) ; BLOOD/BOOY F LDS-BLOOD CELL STUDS(* 15004) BlosystematIc Codes: BOVIDAE(8 57 1 5 ? R& 38370 DIALOG Files: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See F 1 e55 ) (c. BIOSIS 1982) (Item 96 or 858) User 3614 25jan83 2016 23028765 CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER POLY VINYL CHLORIOE AND STRUCTURAL ANALOGS BETHESDA MARYLAND USA MARCH 20-21 1980. NATL INST ENVIRON HEALTH SCI; NATL INST OCCUP SAF HEALTH; OCCUP SAF HEALTH ADM (USA) BETHESDA, MD., USA. ENVIRON HEALTH PERSPECT Coden: EVHPA -It (0). 1981 (RECD. 1982). t - 309. Language: ENGLISH Descriptors: MEETING Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520): BIOCHEM STUO-GENERAL( 10060); TOXI COL-GENL/EXP STUDS.METHSf* 22501 ) 23028674 POWER CONSIDERATIONS IN STUDIES OF REPRODUCTIVE EFFECTS OF VINYL CHLORIDE AND SOME STRUCTURAL ANALOGS. HATCH M; KLINE J: STEIN 2 DIV. EPIDEMIOL.. SCH. PUBLIC HEALTH. COLUMBIA UNIV., 630 WEST 168TH ST., NEW YORK, N.Y. 10032. CONFERENCE TO REEVALUATE THE TOXICITY DF VINYL CHLORIDE MONOMER. POLY{VINYL CHLORIDE) AND STRUCTURAL ANALOGS. BETHESDA. MO., USA, MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (O). 1981 (RECD. 1982). 195-202. Coden: EVHPA Language: ENGL ISH Descriptors: ANIMAL MODEL HUMAN PATERNAL EXPOSURE OCCUPATIONAL HEALTH Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00520): MATHEMATIC BIOL/STATI STIC METH(*04500): BIOCHEM STUD-GENERAL(- 10060): BIOPHYS-BIOCYBERNETICS(* 10515); PATHOLOGY-COMPARAT IVE- (12503): METABOLISM-GENL STUD,METAB PATHW( 1 3002); REPROOUCT SYST-PATHOLOGY(* 16506); TOXICOL-ENVIRONMNTL,INDUSTR(* 22506); DEVE LOPMNTL BIOL-PATHOLOGICAL(*25503); ENVIRON HEALTH-OCCUPAT- NL HEALTH!*37013) Blosystemat1c Codes: VERTEBRATA-UNSPECIFI ED(85150); HOMINID- A E(86 2 15) STUD-PROTEINS.PEPTIDES.AMI NO ACD{ 10064) ; P A Tl IOLOGY - COMP A R A T I V - E{ 12503): METABOLISM-GENL STUD .METAB PATIIWl 13002 ) : METABOLISM-PROTNS,PEPTDS,AM ACDS(* 13012): RESPIRATORY SYST-GE- NL STUD,METHS( 16001); RESPIRATORY SYST-PATHOLOGY( 16006 >; BONE.JNTS,FASC,CONN/AD IP-PATHOL(* 18006); ROUTES OF IMMUN17.TN- FECT.THERAP(22100): TOXI COL-ENVIRONMNTL, I NOUSIR( * 22506 ) : NEOP- LSMS/NEOPL AGNTS-CARCINOGENS!*24007); IMMUNOL/IMMUNOCHEM-IMMU- NOPA T HOL( 3 4 508); ENVIRON HEALTH-OCCUPATNL HEALTH( * 370 1 3 ) ; ENVIRON HEALTH-AIR.WATR.SL POLLN(* 370 1 5) Blosystematic Codes: HOMINIDAE(86215) 23028672 WORKER EXPOSURE TO VINYL CHLORIDE AND POLY VINYL CHLORIOE. JONES J It DIV. SURVEILLANCE, HAZARD EVALUATIONS AND FIELD STUDIES. NATL. INST. OCCUPATIONAL SAFETY AND HEALTH, 4676 COLUMBIA PARKWAY, CINCINNATI, OHIO 45226. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS. BETHESDA. MD.. USA, MAR, 20-21. 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECD. 1982). 129-136. Coden: EVHPA Language: ENGL ISH Descriptors: HUMAN NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY ANO HEALTH USA Concept Codes:. GENL BIOL-INST I TUT,AOMIN,LEGISLN(00508 ) ; GENL BIOL-SYMPOSIA.PROCDNGS,REVW(00520): GENERAL FIELD APPARATUS(0- 1010): BIOCHEM STUD-GENERAL( 10060) ; PATHOLOGY-GENERAL STUDIES! 12 502): PATHOLOGY-COMPARAT IVE{ 12503) : PATHOLOGY-DI AGN OSTIC ( 12504 ); METABOLISM-GENL STUD,METAB PATHW( 13002 ) ; TOXI COL-ENVIRONMNTL.INDUSTR(*22506): ENVIRON HEALTH-OCCUPATNL HEALTH!*37013): ENVIRON HEALTH-A IR,WATR.SL POLLN(37015> B1osystemat1c Codes: HOMINIOAE(66 2 15) 23028673 REVIEW OF PULMONARY EFFECTS OF POLY VINYL CHLORIDE AND VINYL CHLORIDE EXPOSURE. LILIS R ENVIRON. SCI. LAB., DEP. COMMUNITY MED., MOUNT SINAI SCH. MED.. CITY UNIV. N.Y., ONE GUSTAVE LEVY PLACE. NEW YORK, N.Y. 10029. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS, BETHESDA. MO., USA. MAR. 20-21. 19B0. ENVIRON HEALTH PERSPECT 41 (O). 1981 (RECD. 1982).' 167-170. ' Codon: EVHPA Language: ENGLISH Descriptors: HUMAN LUNG CANCER IMMUNO TOXICITY DYSPNEA FIBROSIS INHALATION Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS,REVW(00520): R&S 138371 DIALOG F11e5: GIOSIS Previews 77-83/Jan BA7502;RRM2402(See F11eS5 ) (c. BIOSIS 1982) (Item 100 of 858) User 3614 25Jon83 20 17 23028G63 POLY VINYL CHLORIDE PROCESSES AND PRODUCTS. WHEELER R N JR UNION CARBIDE CORP., P.O. BOX 8361, SOUTH CHARLESTON. W. VA. 25303. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER. POLY{VINYL CHLORIOE) AND STRUCTURAL ANALOGS, BETHESDA. MD., USA, MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (O). 1981 (RECD. 1982). Language: ENGLISH 123- 128. CocJen: EVHPA Descriptors: HUMAN OCCUPATIONAL HEALTH Concept Codes: GENL BIOL-SYMPOSI A.PROCONGS,REVW(00520); BIOCHEM STUD-GENERAL(10060); PATHOLOGY-GENERAL STUD IES( 12502); METABOLISM-GENL STUD.METAB PATHW{13002); TOXICOL-ENVIRONMNTL,- INDUSTR(*22506) ; ENVIRON HEALTH-OCCURATNL HEALTH(* 37013}; ENVIRON HEALTH-AIR.WATR.SL POLLN(*37015) B1osystemat1c Codes: HOMINIDAE{86215) 23028662 EFFECTIVENESS OF FEDERALLY REQUIRED MEDICAL LABORATORY SCREENING IN THE DETECTION OF CHEMICAL LIVER INJURY. TAMBURRO C H; GREENBERG R LIVER RES. CENT.. DIV. DIG. DIS.. DEP. MEO.. UNIV. LOUISVILLE SCH. MED.. LOUISVILLE, KY. 40201. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) AND STRUCTURAL ANALOGS. BETHESDA. MO., USA. MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (O). 1981 (RECD. 1982). 117-122. Coden: EVHPA Language: ENGLISH Descriptors: HUMAN VINYL CHLORIDE CANCER OCCUPATIONAL HEALTH Concept Codes: GENL BIOL-SYMPOSIA,PROCONGS.REVW(00520): BIOCHEM STUO-GENERAL(10060); PATHOLOGY-DIAGNOSTIC(12504); META80LISM-GENL STUD.METAB PATHW ( 1 3002 ) DIGESTIVE SYST -GENL STUDS.METHS(14001); DIGESTIVE SYST-PATHOLOGY(*t4006); TOXICOL- -ENVIRONMNTL,INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-CARCINOGEN- S(* 24007); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-AIR,WATR,SL POLLN(*37015); P!0EMIOL-ORGANIC DIS.NEOPL ASMS (*37054) Blosystemat1c Codes: HOMINIDAE(86215) CYTOLOGY/CYTOCHEM-)IUMAN(02508): BIOCHEM STUD-GENERAL{ 10060); PATHOLOGY-COMPARATIVE( 12 503); PATHOLOGY -0 IAGNOSTIC(* !2504); METABOLISM-GENL STUO,METAB PATHW(13002); 8L00D/B0QY FLDS-OTHER BODY FLDS( 15010): RESPIRATORY SYST-PATHOLOGY(* 16006) : DENTAL/ORAL HIOL-GENL STUO.METHS(19001): DENTAL/ORAL BIOL-PATHOLOGY(* 19006) ; TOXICOL-ENVIRONMNTL,INDUSTR{`2250G) ; NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007}; ENVIRON HEALTH-OCCU- PATNL HEALTHf*37013) ; ENVI RON HEALTH-AIR,WATR.SL POLLN(* 37015 ) BlosysteraatIc Codes: HOMINIDAE(86215 ) ; MUR IOAE(86375 ) 23028660 PRELIMINARY OBSERVATIONS OF THE EFFECT OF INHALATION OF POLY VINYL CHLORIDE IN MAN AND EXPERIMENTAL ANIMALS. WAGNER J C; JOHNSON N F MED. RES. COUNCIL, PNEUMOCONIOSIS UNIT, L LANDOLJGH HOSP, PENARTH, WALES. UK. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, PO L Y{VINY L CHLORIDE) AND STRUCTURAL ANALOGS, BETHESDA. MD., USA. MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECD. 1982). 83-84. Coden: EVHPA Language: ENGLISH Descriptors: RAT PULMONARY TOXICITY DUST OCCUPATIONAL HEALTH Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00520): B IOCHEM - GASES ( 100 12); BIOCHEM STUO-C.ENERAL{ 10060) ; P A THQLOGY - - COMPARATIVEt12503); METABOLISM-GENL STUD,METAB PATHW(13002); RESPIRATORY SYST-GENL STUD,METHS( 1600 1 ) : RESPIRATORY SYST-PATHOLOGY(* 16006); ROUTES OF IMMUNIZ, INFECT,THERAP(2210O) ; TOXI COL -ENVIRONMNTL,INDUSTR{* 22506); ENVIRON HEALTH-OCCUPAT- NL NEALTH( *37013) : ENVIRON HEALTH-A IR.WATR,SL POLLN(*370!5) BlosystematIc Codes: HOMINIDAE(86215); MUR IOAE{86375 ) 23028661 RESULTS OF SPUTUM CYTOLOGY AMONG WORKERS EXPOSED TO VINYL CHLORIOE MONOMER AND TO POLY VINYL CHLORIDE. MALTONI C; LODI P INST. ONCOL., TUMOR CENT., BOLOGNA, ITALY. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POLY(VINYL CHLORIDE) ANO STRUCTURAL ANALOGS, BETHESDA. MD., USA, MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (O). 1981 (RECO. 1982). 85-88. Coden: EVHPA Language: ENGLISH Descriptors: HUMAN MOUSE LUNG CANCER CYTO TOXICITY PULMONARY TOXICITY Concept Codes: CYTOLOGY /rvmrHFH- GENL BI OL-S YMPOS I A . PROCDNGS , RE VW( 00520.) : i f '. R&S 138372 DIALOG FUe5: BIOSIS Previews 77-83/dan BA7502 ; RRM2402 ( See F11e55) (c. BIOSIS 1982) {Item 104 of 858) User 36U 25Jan83 20 18 2302BG59 PNEUMOCONIOSIS IN ANIMALS EXPOSED TO POLY VINYL CHLORIDE DUST. GROTH 0 H; LYNCH D W; MOORMAN W d; STETTLER L E: LEWIS T R; WAGNER W O: KOMMINENI C DIV. 8I0MED. BEHAVIORAL SCI., OEP. HEALTH HUMAN SERV., NATL. INST. OCCUPATIONAL SAFETY ANO HEALTH. ROBERT A. TAFT LABS., CINCINNATI, OHIO 45226. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER. POLY(VI NY L CHLORIDE) AND STRUCTURAL ANALOGS, BE THESDA, MD. , USA. MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 {RECD. 1982). 73-82. Coden: EVHPA Language: ENGLISH Descriptors: RAT GUINEA-PIG MONKEY MACROPHAGE Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS,REVW(00520): CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM-GASES(10012); BIOCHEM STUO-GENERAL( 10060); PATHOLOGY-COMPARAT IVE{ I 2503); METABOLISM- -GENL STUO.MET AB PATHW( 13002): BLOOD/BODY F LDS -BLOOD CELL STUDS(* 15004): BLOOO/BOOY FLDS-BLD,LYM,RES PATH{* 15006): RESPIRATORY SYST-GENL STUD,METHS(16001): RESPIRATORY SYST-PATHOLOGY(* 16006); ROUTES OF IMMUNIZ,INFECT,THERAP(22100) ; TOXICOL -ENVIRONMNTL,INDUSTR(* 2 2506); ENVIRON HEALTH-OCCUPAT- NL HEALTH(37013); ENVIRON HEALTH-AIR,WATR,SL POLLN{*37015) B 1 osys terra 11c Codes: PRI MATES-UNSPEC I F I E0( 86 190 ) ; CA V I I DAE ( - 86300); MURIDAE(86375) 23028226 MORTALITY AMONG POLY VINYL CHLORIDE FABRICATING EMPLOYEES. CHIAZZE'L OR: FERENCE L 0 DIV. BIOSTATISTIC EPIDEMIOL.. GEORGETOWN UNIV. SCH. MED., 3750 RESERVOIR RO., N. W.. WASHINGTON, D.C . 20007. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLDRIOE MONOMER. POLY(VI NY L CHLORIDE) AND STRUCTURAL ANALOGS, BETHESDA, MD., USA, MAR. 20-21, 1980. ENVIRON HEALTH PERSPECT 41 (0). 1981 (RECO. 1982). 137-144. Coden: EVHPA Language: ENGL ISH Descriptors: HUMAN BREAST CANCER DIGESTIVE CANCER Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520): SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUO-GENERAL(10060): PATHOLOGY-COMPARATIVE( 12503); PATHOLOGY-NECROS15( 12510); META- BOLISM-GENL STUO,METAB PATHW(13002); DIGESTIVE SYST-PATHOLOGY- (*14006); REPRODUCT SYST-PATHOLOGY(*16506); TOXICOL-ENVIRONMN TL , INDUSTR{ * 22506 ) ; NEOPLSMS/NEOPL AGNTS-CARCINOC,ENS( *24007 ) ; ENVIRON HEALTH-OCCUPATNL HEAlTH(* 37013); ENVIRON HEALTH-A IR.W- ATR.SL POLLN(*37015); EPIDEMIOL-ORGANIC DIS.NEOPLASMS(*37054) B1osystema t1c Codes: HOMINIOAE(862J5) BETHESDA. ML).. USA. MAR. 20-21. 1980. ENVIRON HEALTH PERSPECT 41 (O). 1981 {RECO. 1982). 95-tOO. Codon: E VI IP A Language: ENGLISH Descriptors: HUMAN CANCER Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520} ; BIOCHEM STUD-GENERAL{10060); PATHOLOGY-GENERAL STUOIES(12502); PA THQ LOGY -COMPARATIVE(12503): PATHOLOGY-NECROSIS{12510) : META- 80LISM-GENL STUO.METAB PATHW{ 13002); TOX I COL-ENVIRONMNTL. INDU- STR(*22506): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS{* 24007 ); ENVIRON HEALTH-OCCUPATNL HEALTHt*37013); ENVIRON HEALTH-A IR,WATR.SL POLLNt*37015) : EPI DEMIOL-ORGAN IC 0 IS.NEOPLASMS( * 37054 ) B losystematSc Codes: HOMINIDAE(86215) 23028 1 39 ENVIRONMENTAL PROTECTION AGENCY USA PROGRAMS OF VINYL CHLORIDE MONITORING IN AMBIENT AIR. DIMMICK W F EMISSION STANDARDS ENG. DIV., U.S. ENVIRON. AGENCY, RESEARCH TRIANGLE PARK. N.C. 27711. PROTECTION CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER, POL Y(V I NY L CHLORIDE) AND STRUCTURAL ANALOGS. BETHESDA. MO.. USA. MAR. 20-21, 1980. 41 (0). 1981 (RECD. 1982). 203-206. ENVIRON HEALTH PERSPECT Coden: EVHPA Language: ENGL ISH Descriptors: AIR POLLUTION Concept Codes: GENL BIOL-INST I TUT.ADMIN,LEG1SLN(00508) ; GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520) ; GENERAL FIELD AP PA RA TU S(O1010): E COL OGY-GENL STUD IES,METHODS(07502); E COLOG Y-BIOC LIMA T- OL.BIGMETEORDLt*07504); BIOCHEM-GASES( 10012); BIOCHEM METH-GENERAL(*10050); BIOCHEM STUO-GENERAL(10060}; TOXICOL-ENV[RONMNTL,INOUST R(22506): ENVI RON HEALTH-AIR,WATR,SL P0LLN(*370 15) 23020224 GERMAN INVESTIGATIONS ON. MORBIDITY AND MORTALITY OF WORKERS EXPOSED TO VINYL CHLORIDE. WEBER M; RE INL W; GRE1SER E STAATLICHER GEWERBEARZT, DUESSELDORF, W. GER. CONFERENCE TO REEVALUATE THE TOXICITY OF VINYL CHLORIDE MONOMER. POLY(VINYL CHLORIDE) AND STRUCTURA1 ANAinnc DIALOG F11e5: BIOSIS Previews, 77-83/dan BA7502;! R&S 1383 ) ic. BIOSIS 1982) (Item 108 of 858) User 3614 25jan83 20 19 23024499 IDIOPATHIC PORTAL HYPERTENSION A REVIEW. OATTA 0 V; 8HAGWAT A G DEP. OF LIVER DISEASES. BULL POSTGRAD INST MED EDUC RES CHANDIGARH 15 (4). 1901 (RECO. 1902). 173-192. Coden: BPIRD Language: ENGLISH Descriptors: HUMAN ARSENIC COPPER VITAMIN A VINYL CHLCjR IDE MONOMER NONCIRRHOTIC PORTAL FIBROSIS HEPATO PORTAL SCLEROSIS OBLITERATIVE PORTAL VENOPATHY BANT IS SYNDROME CIRRHOSIS BUOD CHIARI SYNDROME EXTRAHEPATIC PORTAL VENOUS OBSTRUCTION HEPATIC VENOUS OUTFLOW OBSTRUCTION CONGENITAL HEPATIC FIBROSIS PARTIAL NODULAR TRANSFORMATION SCHISTOSOMIASIS NODULAR REGENERATIVE HYPERPLASIA FELTYS SYNDROME MYELO PROLIFERATIVE DISORDERS HEPATIC ANGIO SARCOMA HISTOLOGY Concept Codes: MICROSCOPY-HISTOL,HISTOCHEM TECH(01056); BIOCHEM STUD-GENERAL!10060); BIOCHEM STUD-VITAMINS(10063): BIOCHEM STUD-LIPIOS(10066); MINERALS( 10069); ANATOMY/HISTOL-M- ICRO,ULTRAMICRSC(11100); PATHOLOGY-COMPARAT IVE( 12503); PATHOL OGY-DIAGNOSTIC! 12504); PATHOLOGY-INFLAMMATN,INFLAM OIS(12508); DIGESTIVE SYST-ANATOMY(14002): DIGESTIVE SYST-PATHOLOGY!* 1400- 6); CARO IOVASC SYST-ANATOMY( 14502); CARDIOVASC SYST-BLD VESS PATHOL( * 1 4 500); BLOOD/BODY FLOS-BLD,LYM,RES PATH! 15006); BLOOO/SOOY FLDS-LYMPHAT TISS,RES(15008): BONE.JNTS.FASC.CONN/- ADIP-PATHOL!18006): TOXICOL-GENL/EXP STUDS,METHS(22501); NFOPLSMS/NEOPL AGNTS-PATH,CL INIC(24004); OEVELOPMNTL BIOL-DES- CRIP TERATDL!25552); IMMUNQL/IMMUNOCHEM-IMMUNOPATHOL(34500); PARAS ITOLOGY-MEDICAL!60504); INVERTS PHYS10L-PLATYHELMINTHES{- 64010) BlosystematIc Codes: TREMATODA(45200); HOMINIDAE!86215) 23023006 DOES THIS PATIENT HAVE VINYL CHLORIDE DISEASE?. OIERICKX L; DEGHEEF H DEP. DERMATOL., AKAO. ZIEKEN1IUIS ST.-PIETER, BRUSSELSESTR. 69. 3000 LEUVEN. BELG. CONTACT OERMATITIS 7 (6). 1981 {RECO. 1902). 356-357. Coden: CODED Language: ENGLISH Descriptors: FINGER NAIL CARPENTRY WINDOW FRAME INSTALLATION Concept Codes: BIOCHEM STUD-GENERAL(10060); CHOROATE BODY REGNS-EXIREMITIES(11318); INTEGUMENT SYST-PATHOLOGY(* 18506): TOXI COL -ENVIRONMNT L,INDUSTR!*22506); ENVIRON HEALTH-OCCUPATNL HEALTH!*37013) Blosystematic Codes: HOMINIDAE(86215) ASPEN, COLO. , USA. JUNE 11-14, 1900. CHEST 80 (SUPPL . 1 ) . 1961. 60S. Coden: CHETB Language: ENGLISH Descriptors: HUMAN DYSPNEA SMOKING AGE Concept Codes: GENL BIOL-SYMPOSI A.PROCONGS,REVW(00520 ) ; BEHAVIOR BIOL-HUMAN BEHAVI OR(07004); BIOCHEM-GASES( 10012); BIOCHEM STUD-GENERAL!10060); PATHOLOGY-COMPARATIVE( 12503 ) ; META8DLISM-GENL STUD,METAB PATHW(13002); RESPIRATORY SYST-GENL STUD.METHS! 16001 ); RESPIRATORY SYST-PATHOLOGY(*16006) : PSYCHIATRY-ADDICT I0N(INC SMOKNG)(2 1004); ROUTES OF IMMUN12,INFECT,THERAP(2210O); TOXI COL-GENL/EXP STUDS.METHS{ * 2 - 2501); TOXICOL-ENVIRONMNTL,INDUSTR!*22506); OEVELOPMNTL B1OL-GEN MORPHGE NS IS!25508) ; ENVIRON HEALTH-OCCUPATNL HEALTH!*37013); ENVIRON HEALTH-A IR,WATR,SL POLLN( * 37015); EPIDEMIOL-ORGANIC OIS.NEOPLASMS(* 37054); PLANT PHYSIOL-CHEM CONSI ITUENfS(51522); AGRONOMY - TOOACCO CR0PS(52512 ) 8losystemat(c Codes: SOLANACEAE(26775); HOMINI DAE(862 1 5 ) 23022970 VINYL CHLORIDE DISORDER. WALKER A E ROYAL HOSPITAL. CHESTERFIELD, DERBYSHIRE. SYMPOSIUM ON OCCUPATIONAL SKIN DISEASE, STRATFORD-UPON-AVON. WARWICKS.. ENGLAND. APRIL 10*11. 1981. BR J DERMATOL 105 (21). 1981. 19-22. Coden: BJDSA Language; ENGLISH Descriptors; HUMAN ANIMAL INHALATION NEURO TOXICITY ACRO OSTEOLYSIS SKIN CANCER SCLERODERMA RAYNAUDS DISEASE CRYO GLOBULIN Concept Codes: GENL BIOL-SYMPOSI A.PROCONGS.REVW(00520); CLIN BIOCIIEM-GENL STUDIES( 10006); BtOCHEM-GASES( 10O12) ; BIOCHEM STUD-GENERAL!10060); BIOCHEM STUD-PROTEI NS,PEPTIOES.AM I NO ACD(10064); BIOCHEM STUD-CARBOHYDR.(10068); EXTERN EFF-COLO! 10616); CHORDATE BODY REGNS-EXTREMIT I ES( 11318); PATHOLOGY-COMPARATIVE! 12503) ; PATHOLOGY-I NTLAMMATN. INFLAM OIS* (12508); METABOLISM-GENL STUD.METAB PATHW(13002): METABOLISM-- CARBOHYDRATES! 13004>; METABOLISM-PROTNS.PEPTDS,AM ACDS! 13012): RESPIRATORY SYST-GENL STUO.METHS( 1600 I); BONE.JNTS.FASC.CONN/- AOIP-PATHQL!* 18006); INTEGUMENT SYST-PATHOLOGY( 18506) ; NERVOUS SYST-PATHOLOGY!*20506); ROUTES OF IMMUNIZ,INFECT.THER- A P{2 2100); TOXICOL-ENVIRONMNTL. INDUSTR!*22506) ; TEMPERATURE-C R YOB IOLOGY(23004); TEMPERATURE-HYPO.HYPERTHERMI A( *23006) ; NF 0 - PLSMS/NEGPL AGNTS-CARCINOGENS!*24007); IMMUNOL/IMMUNOCHEM-IMM UNOPATHOL! *34 508 ) ; ENVIRON HE AL TH - OCCUP A TNL HE A L, I H ( 3 70 I 3 ) ; ENVIRON HEALTH-AIR,WATR.SL POLLN(`37015) BlosystematIc Codes: VERTEBRATA-UNSPECIFI ED(85150): HOMINI0AE(862 15) 23023000 AN EPIDEMIOLOGIC STUDY OF RESPIRATORY DISEASE IN WORKERS EXPOSED TO POLY VINYL CHLORIDE DUST. ' SOUTAR C: COPLAND L; THORNLEY P; HURLEY F; OTTERY J; ADAMS W ; BENNETT B INST. OCCUPATIONAL MED., ROXBURGH PLACE, EDINBURGH. SCOTL., UK. icpcm i imp foMff r*r*i i r DIALOG File5: BIOSIS Previews 77-83/dan 8A7502;RRM2402(See Fii s 138374 tc. BIOSIS 1982) (Item 112 of 858) User 36(4 25Jan83 2020 2 302 2 A 17 MEAT WRAPPERS ASTHMA. BUTLER d; CULVER B H; ROBERTSON l< T OEP. MED., UNIV. WASH., SEATTLE. 23 RO ASPEN LUNG CONFERENCE: THE ENVIRONMENT AND THE LUNG, ASPEN, COLO., USA. dUNE 1 1 - 14 . 1981. 7 1S-73S. Coden: CHETB 1980. CHEST 80 (SUPPL. 1). Language: ENGLISH Descriptors: HUMAN POLY VINYL CHLORIDE COLD INHALATION Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520 ) ; SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD-GENERAL(10060): EXTERN EFF-COLD( 10616); METABOLISM-GENL STUD,ME T AB PATHW(13002); RESPIRATORY SYST-GENL STUD,METHSC16001); RESPIRATORY SYST-PATHOLOGY( +16006); ROUTES OF IMMUNIZ.INFECT.- THERAPt22100): TOXICOL-ENVIRONMNTL. INOUSTR(* 22506); ENVIRON HEALTH-OCCUPATNL HEALTH(* J7013): POL LN(+37015) ENVIRON HEALTH-A IR,WATR.SL Biosystemat1c Codes: HOMINIDAE(86215) 23022404 DETERMINATION OF VINYL CHLORIDE IN WATER BY HEADSPACE ANALYSIS WITH A PHOTO IONIZATION DETECTOR. STEIN V 8; NARANG R S TOXICOL. INST., DIV. LAB. RES., N.Y. 'STATE OEP. HEALTH. ALBANY, N.Y. 12201. BULL ENVIRON CONTAM TOXICOL 27 (5). 1981. 583-587. Coden: BECTA Language: ENGL ISH Descriptors: WATER POLLUTION Concept Codes: GENERAL FIELD METHODS(01008); GENERAL FIELD APPARATUS!OlOtO): ECOLOGY-GENL STUDIES.MLTIIOOS(07502); ECOLOGY-WATR RESRCH.FISHERY 8I0L(075t7); BIOCHEM METH-GENERAL- (10050); BIOCHEM STUO-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH(10504); TOXI COL-ENVIRONMNTL.INDUSTR(22506); ENVIRON HEALTH-AIR.WATR,SL POLLNf*37015) 23020700 REACTIVE METABOLITES AND CARCINOGENICITY OF HALOGENATED ETHYLENES. BOLT H M; LA 18 R d; FILSER d G PHARMAKOL. INST., ABT. TOXIKOL.. dOHANNES GUTENBERG-UNIV. MAINZ, OBERE ZAHLBACHER STR. 67. 0-6500 MAINZ, W. GER. BIOCHEM PHARMACOL 31 (1). 1982. 1-4. Coden: BCPCA Language: ENGLISH Descriptors: ESCHERICHI A-COL I SALMONELLA -TYPHIMURIUM RAT VINYL FLUORIDE VINYLI DENE FLUORIDE VINYL CHIORIDE VINY LIDENE CHLORIDE TRI 'CHLORO ETHYLENE PER CHLORO ETHYLENE VINYL BROMIDE Concept Codes: BIOCHEM STUD-GENERAL(10060); METABOLISM-GENL STUD,MET AB PATHW(* 13002); TOXI COL-GENL/EXP S1UDS.ME IMS( 72501 ) ; NEOPLSMS/NCOPL AGNTS-CARCINOGENS(24007) Blosystemat1c Codes: ENTEROBACTERI ACEAE{040 to); MUR I DAE(8G3- 75) 23016487 A DEFENSE OF CANCER CASE CLUSTER STUDIES. ALDRICH I E; GARCIA N; BERGER S; ZEICKNER S; SANCHEZ tf U. MIAMI SCH. MED.. MIAMI. FL 33101. 14TH ANNUAL MEETING OF THE SOCIETY FOR EPIDEMIOLOGIC RESEARCH. SNOWBIRD. UTAH, USA, JUNE 17-19. 1981. AM J EPIDEMIOL 114 (3). 1981. 442. Codon: AdEPA Language: ENGLISH Descriptors: ABSTRACT HUMAN DI ETHYL STILBESTROL VINYL CHLORIDE ASBESTOS CARCINOGEN Concept Codes: GENL , BIOL-SYMPOSI A.PROCDNGS.REVW(00520 ) : BIOCHEM STUO-GENERAL( 10060) : ENDOCRINE SYST-GONAOS.PLACENTA( - 17006); TOXICOL-PHARMACOLOGICALt*22504); TOXICOL-ENVIRONMNTl,- INOUSTR(*22506); NEOPLSMS/NEOPL AGNTS-GENL STUDS{*24002); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007); PUB HEALTH-A0M1NI ST - R.STATISTICS{*37010); EPI DEMIOL-ORGANIC DIS,NEOPLASMS(* 37054 ) Btosystematfc Codes: HOMINIOAE(86215) 23014703 MULTI STAGE DOSE RESPONSE MODELS IN CARCINOGENESIS. carlborg r w 400 SOUTH NINTH ST.. SAINT CHARLES. ILLINOIS 60174. FOOD COSMET TOXICOL 19 (3). 1981. 361-366. Codon: FCTXA Language: ENGLISH DescrIptors: MOUSE RAT DDT VINYL CHLORIDE DI ETHYL ST ILBESTROL CARCINOGEN DOSE LIVER ANGID SARCOMA MAMMARY CARCINOMA NASAL ADENO CARCINOMA Concept Codes: MATHEMATIC BIOL/STAT I ST IC METH(04 500) : BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD - STEROLS.STEROIDS( 10- 067); 8 IOPHY S-8 IOCYBE RNE TIC S(+ 10515); DIGESTIVE SYST-PATHOLOG - Y( * 14 006); CARD IOVASC SYST-BLD VESS PATHQL(* 14508) ; RESPIRATORY SYST-PA IHOLOGY( * 16006); REPROOUCT SYST-PATHOLOGY( - * 16506): ENDOCRINE SYST-GONADS.PLACENTA( 17006); PHARMACOL-ENO - OCR 1NE SYST(220 16); TOXICOL-GENL/EXP STUOS,METHS{2250 1 ) : TOXI COL-PHARMACOLOGICAL(22504); T OX I COL -ENVIRONMNT L.INDUST R(22506) ; NEOPLSMS/NEOPL AGNTS-CARC- INOGENS(* 24007); PEST CONTRL 0ENL/PESTICS/HERBICS(54600) B iosystematic Codes; MURIOAE(86375) 138375 DIALOG FHe5: BIOSIS Prevlews. 77-83/Jan 8A7502;RRM2402(See F I 1e55) (c. BIOSIS 1983) (Item 117 of 858) User 3614 25Jan83 202 1 23013702 METABOLIC ACTIVATION AND MUTAGENICITY OF 4 VINYLIC MONOMERS VINYL CHLORIDE STYRENE ACRYLO NITRILE BUTADIENE. DUVERGER M; LAMBOTTE M: MALVOISIN E: DE MEESTER C; PONCELET F: MERCIER M LAB. OF BIOTOXICOLOGY. UNIV. OF LOUVAIN. SCU. OF PHARMACY. U.C.L.-73.69, B. 1 200 BRUSSELS. BELGIUM. TOXICOL EUR RES 3 (3). 1981. 131-140. Codenr TOERD, Language: ENGL ISH Descriptors: SALMONELLA-TYPHIMURIUM ESCHERI CHI A-COL I SCHIZOSACCHAROMYCES-POMBE SACCHAROMYCES-CEREVISIAE OROSOPHILA- -MELANOGASTER CHINESE HAMSTER LUNG V-79 CELL CHINESE HAMSTER OVARY CHO CELL MIXED FUNCTION OXIDASE ENDOPLASMIC RETICULUM CHROMOSOME ABERRATION Concep t Codes: CYTOLOGY/CYTOCHEM-PLANT(*02 504 ); CYTOLOGY/CY- TOCHEM-ANIMALt*02506); GENETICS/CYTOGENET-GENL STUOIES(*03502) ; GENETICS/CYTOGENET-PLANT(03504) ; GENETICS/CYTOGENET-AN IMAL- (*03506); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUO-PROTEINS.- PEPTIDES.AMINO ACD{ 10064); ENZYMES-PHYSIOLOG1CAL STUDIES(* 108- 08); METABOLISM-GENL STUD.METAB PATHW(13002); METABOLISM-PROT- NS.PEPTDS.AM ACDS(* 1 30 1 2); RESPIRATORY SYST-GENL STUO.METHS( 1- 6001): REPRODUCT SYST-GENL STUDS,METHS(16501); TOXICOL-GENL/E- XP STUDS.METHSt*22501); TISS CULTURE-APPARAT.METHS.MED I A(3250- O): INVERTB PHYSIOL -INSECTA-PHYSIOL(*64076) Blosystematic Codes: ENTERDBACTERIACEAE(04810): ASCOMYCETES- (15100); 01PTERAf 75314); CRICETI DAE(86310) 23009340 GAS CHROMATOGRAPHIC DETERMINATION OF VINYL CHLORIDE IN ATMOSPHERIC.AIR. IL'ICHEVA G V; KUZNETSOVA L V GORKI RES. INST. IND. HYG. OCCUP. OIS.. GORKI. USSR. GIG SANIT 0 (7). 1981. 52-54. Coden: GISAA Language: RUSSIAN Descriptors: NOTE CARCINOGEN SEASONAL EFFECT AIR- POLLUTION Concept Codes: GENERAL FIELD METHODS(O1008): GENERAL FIELD APPARATUS(O1010); ECOLOGY-GENL STUD!ES.METHODS(07502); ECOLOGY-BIOCLIMATOL.BIOMETEOROL(*07 504 ); BIOCHEM-GASES( 10012); BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUO-GENERAL(10060) ; BIOPHYS-GENERAL 8I0PHYS TECK{10504); MOVEMENT{12IOO); TOXICOL-ENVIRONMNTL,INDUSTR(22506); NEOPLSMS/NEOPL AGNTS-CARC- INOGENS(*24007); ENVIRON HEALTH-A IR.WATR.SL POLLN(370 1 5 ) TOGENET-HUMAN(*03508); BIOCHEM STUD-GENERAL(10060); PATHOLOGY - -NECROSISt 125 10); BL000/800Y F LDS-OTHER BODY FLDSl 15010): REPRODUCT SYST-GENL STUDS.METHS( 1 6501 ); TOXI COL-ENVIRONMNTL. I - NOUSTR(*22506); ENVIRON HEALTH-OCCUPATNL HEALTH(*370 1 3): ENVIRON HEALTH-AIR.WATR.SL POLLN(* 37015) Blosystematic Codes: HOMINIDAE(862 1 5 ) 22069803 A PROPOSED HYGIENIC STANDARD FOR VINYL CHLORIDE. KURLYANDSKII B A; STOVBUR N N; TURUSOV V S MIJNIC. SANIT . - EPIDEMIOL. . MOSCOW, USSR . GIG SANIT 0 (3). 1981. 74-75. Coden: GISAA Language: RUSS I AN Descriptors: NOTE HUMAN CARCINOGEN EMBRYO TOXICITY TERATOGEN Concept Codes: BIOCHEM STUD-GENERAL(10060): PATHOLOGY-GENER- AL STUDIES( 12502); PATHOLOGY-COMPARAT IVE( 12503 ) ; METABOLISM-G- ENL STUD.MET AB PATHW( 13002) ; TOXI COL-GENL/EXP STUOS.METHS(* 22- 501): NEOPLSMS/NEOPL AGNTS-CARC INOGENS(* 24007) ; DEVELOPMNTL BI0L-PATH0L0G1CAL(*25503); DEVELOPMNTL BIOL-GEN MORPHGENSIS(* - 25508 ): DEVELOPMNTL BIOL-DESCRIP TERATOL(25552 ) BlosystematIc Codos: HOMINIDAE(86215) 22069737 LUNG FIBROSIS IN POLY VINYL CHLORIDE WORKERS. HUNTER A M; WAGNER U C; JOHNSTON N; SEATON A JOINT SUMMER MEETING OF THE SCOTTISH THORACIC SOCIETY AND THE THORACIC SOCIETY. ST. ANDREWS. SCOTLAND. JULY 2-3. 1981. THORAX 36 (9). 1981. 711-712. Coden: THORA Language: ENGLISH Descriptors: ABSTRACT HISTOLOGY ELECTRON MICROSCOPY Concept Codes: GENL B10L-SYMPOSI A,PROCDNGS.REVW(00520): MICROSCOPY-HJSTOL.HISTOCHEM TECH(01056); ELECTRON MICRDSCOPYt- 0105B); SOCIAL BIOL/HUMAN ECOLOGY(*05500) : BIOCHEM STUO-GENERAL( 10060); ANATOMY/HI STOL-MICRO.ULTRAM ICftSC(*11108): RESPIRATORY 5YST- PATHOLOGY(* 16006); TOXICOL-ENVIRONMNTl. , I NOUS- TR(*22506 ) ; ENVIRON HEALTH-0CCUPATNL HEALTH(37013) BlosysteraatIc Codes: HOMINIDAE(86215) 23002475 THE ROLE.OF HUMAN GENETIC MONITORING IN THE WORKPLACE. DABNEY B J IBM CORPORATION. P.O. BOX 1900, BOULDER, CO. 80302. J OCCUP MED 23 (9). 19B1. 626-631. Coden: JOCMA Language: ENGLISH Descriptors: HUMAN SPERM BODY FLUID SOMATIC CELL VARIANT BENZENE VINYL CHLDRIDE MONOMER EPI CHLURIIYDRIN SISTER CHROMATID EXCHANGE STATISTICAL DESIGN GENETICALLY RELEVANT END POINT DI ALO e5: BIOSIS Previews 77-83/0an BA7502:RRM2402(See F R&S 138376 22063948 SATURABLE METABOLISM AND ITS RELATIONSHIP ,u iumliU, ANOERSEN M E TOXICOL. BRANCH, AIR FORCE AEROSPACE MED. RES. LAB., WRIGHT-PATTERSON AIR FORCE BASE, OHIO. CRJT REV TOXICOL 9 (2). 1981. 105-150. Codon: CRTX8 Language: ENGLISH Descriptors: REVIEW RAT 2 4 5-T STYRENE VINYL CHLORIDE PHARMACO KINETICS INHALATION Concept Codes: 8IOCHEM-GASES( 10012); BIOCHEM STUD-GENERAL( 1- 0060); PATHOLOGY-GENERAL STUDIES(12502); PATHOLOGY-COMPARAT IV- E(12503); METABOLISM-GENL STUD,METAB PATHW(13002}; RESPIRATORY SYST-GENL STUD,METHS(16001): PHARMACOL-DRUG METAB,METAB STIMU(*22003); ROUTES OF IMMUNIZ,INFECT,THERAP(221OO): TOXICOL-GENL/EXP STUDS.METHS(*22501); TOXICOL-PHARMACOLOGICAL- (*22504); PLANT PKYSIOL-GROWTH SUBSTANCES(51514); AGRONOMY-WE EDS AND WEED CONTROL{52518): PHYTOPA IHOL-NONPARASITIC 0ISEASE(54512) ; PEST CONTRL GENL/PESTICS/HERBICS(*54600) Blosystemat1c Codes: MURIDAE(86375) 22063890 VINYL CHLORIDE DISORDER. WALKER A E ROYAL HOSPITAL, CHESTERFIELD, DERBYSHIRE. MEETING ON OCCUPATIONAL SKIN DISEASE, STRATFORD-ON-AVON, WARWICKS.. ENGLAND. APR. 10-11, 1981. 105 (21). 1981. 19-22. Coden: BdDSA Language: ENGLISH BR J DERMATOL SUPPL Descriptors: HUMAN ANIMAL POLY VINYL CHLORIDE LIVER ACRO OSTEOLYSIS SCLERODERMA CARCINOGEN RAYNAUDS DISEASE I MMUNO PATHOLOGY Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(O0520): BIOCHEM-GASES(100t2): BIOCHEM STUD-GENERAL(10060): CHOROATE BODY REGNS-EXTREMITIES( 11318); PATHOLOGY-GENERAL STUD IES( 12502); PATHOLOGY-COMPARAT IVE( 1 2 503): METABOLISM-GENL STUD,METAB PATHW(13002): DIGESTIVE SYST-PATHOLOGY(14006); RESPIRATORY SYST-GENL STUD,METHS(16001); BONE.UNTS.FASC,CONN/AOIP-PATHOL(- *18006); INTEGUMENT SYST-PATHOLOGY(*18506); ROUTES OF IMMUNIZ.INFECT,THERAP(22lOO): TOXI COL-ENV1RONMNTL,INDUSTR(*22506): NEOPLSMS/NEOPL AGNTS-CAR- CINQGENSt *24007); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(*34508); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-A IR,W- ATR.SL POLLN(*37015) BtosystematIc Codes: VERTEBRATA-UNSPECIFI ED(85150): HOMINIDAE(062 15) (c. BIOSIS 1982) (Item 122 of 858) User 3614 25jan83 2022 SKIN CARCINOGEN Concept Codes: BIOCHEM-GASESt lOO12) : BIOCHEM STUO-GENERAL( 1 - 0060): MINERALS!10069); PATHOLOGY-COMPARATIVE(12503); METABOLISM-GENL STUO.METAB PATHW( 13002 >; M INERALS( 1 30 10): INTEGUMENT SVST-PATHOLOGY(* 18 506) ; TOX I COL -ENVIRONMNTL, INDUST- R(* 22506); NEOPLSMS/NEOPL AGNTS-CARCINOGENSI*24007); ENVIRON HEALTH-OCCUPATNL HEALTH{*37013); POL LN(*37015) ENVIRON HEALTH-AIR.WATR , SL BlosystematSc Codes: HOMINIDAE(86215); MURIOAE{86375 ) 22058028 GAS CHROMATOGRAPHIC DETERMINATION OF VINYL CHLORIDE IN AIR. DMITRIEV M T; MISHCHIKHIN V A MOSCOW, USSR. GIG SANIT 0 (4). 1981. 46-49, Coden: GISAA Language: RUSSIAN Descriptors: HEALTH NOTE HUMAN POLY VINYL CHLORIOE OCCUPATIONAL Concept Codes: GENERAL FIELD METHODS(01008); GENERAL FIELD APPARATUS(OIOIO): 8 IOCHEM-GASES( 10OI 2); BIOCHEM METH-GENERAL(- *10050): BIOCHEM STUD-GENERAL(10060): BIOPHYS-GENERAL 8I0PIIYS TCH( 10504); MOVEMENT( 12100): PATHOLOGY-GENERAL STUD IES( 12502) ; MET ABOLISM-GENL STUO.METAB PATHW{ 13002) ; TOXI COL-ENVIRONMNT- L.INDUSTRf*22506); ENVIRON HEALTH-OCCUPATNL HEALTH( * 370 1 3); ENVIRON HEALTH-AIR,WATR.SL POLLN(*37015) B losystemat1c Codes: MOM INIOAE(86215) 22054 186 MECHANICAL METHOD FOR SYNANTHROPIC COCKROACH CONTROL. PENEV I; C1IEL'EVSK1 S: TOSHEV G; MLADENOV M: VOOENICHAROV P INST. TRANSPORT MEO.. SOFIA, BULG. MED PARAZITOL PARAZIT BOLEZNI 50 ( 1 ) . 1981. 48 - 49. Coden: MPPBA Language: RUSSIAN Descriptors: BLATTA-OR IENTALIS BLATTA-GERMANICA POLY VINYL CHLORIDE RESIN Concept Codes: BIOCHEM METH-GENERAL(10050); BIOCHEM STUD-GENERAL(* 10060); PEST CONTRL GENL/PESTICS/HERBICS( *54600> ; ECONOM ENTOMOL-ANIMAL PE STS( * 60012); ECONOM ENTOMOL-CHEM PHYS CONTRL(*60016): SANITARY ENTOMOLOGY{* 61000) Blosystemat1c Codes: QRTHOPTERA(7 5340) 22061665 CURRENT PROBLEMS IN OCCUPATIONAL HYGIENE IN PRODUCTION OF PLASTICS LITERATURE REVIEW. SHEVCHENKO A M; YAVOROVSKII A P A.A. BOGOMOLETS MED. INST.. KIEV, USSR. GIG TP PROF ZABOL 0 (5). 19B1. 24-28. Coden: GTPZA Language: RUSSIAN Descriptors: HUMAN MOUSE GLASS FIBER POLY VINYL CHLORIDE AIR DIALOG Fi!e5: BIOSIS Previews 77-B3/dan BA7S R&S 138377 2205 16 18 POWER CONSIDERATIONS IN EPIDEMIOLOGIC STUDIES OP VINYL CHLORIDE WORKERS. BEAUMONT U d: BRESLOW N E NIOSH, CINCINNATI, OH 45226. 14 TH ANNUAL MEETING OF THE SOCIETY FDR EPIDEMIOLOGIC RESEARCH. SNOWBIRD, UTAH, USA, dUNE 17 - 19. 1981. AM d EPIDEMIOL 114 (3). 198 1. 438. Coden: AdEPA Language: ENGL ISH Descriptors: MORTALITY ABSTRACT HUMAN LUNG BRAIN LIVER CANCER Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520); SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCMEM STUD-GENERAL(10060); PATHOLOGY -COMPARATIVE{ 12 503); PATHOLOGY-NECROSIS( 12510): METABOLISM-GENL STUD,METAB PATHW( 13002); DIGESTIVE SYST-PATHOLOGY- (*14006): RESPIRATORY SYST-PATHOLOGY(*16006>; NERVOUS SYST-PATHOLOGY(*20506); TOXICOL-ENVIRONMNTL, INDUSTR( *22506 ) ; NEOPLSMS/NEOPL AC.NT S-C ARC I NOGENS ( *24 007 ) ; ENVIRON HEALTH-OCCU- PATNL HEALTH{*37013); ENVIRON HEALTH-A IR,WATR.SL POLLN(*37015 ) ; EPIDEMIOL-ORGANIC DIS.NEOPLASMS(*37054) Blosystemat1c Codes: HOMINIDAE(86215) 22050201 ABSORPTION OF ISOSORBIDE DI NITRATE BY POLY VINYL CHLORIDE INFUSION BAGS AND ADMINISTRATION SETS. LEE M G; FENTON-MAY V PHARMACY DEP., UNIV. HOSP. WALES. HEATH PARK. CARDIFF, d CLIN HOSP PHARM 6 (3).' 1981. 209-212. Coden: dCKPD Language: ENGLISH Descriptors: HUMAN CARDI OVASCULAR-DRUG MYO CARDIAL INFARCTION POTENCY GLASS POLY PROPYLENE PHARMACO KINETICS Concept Codes: BIOCHEM STUD-GENERAL( 10060): PATHOLOGY-THERA- PY(125 12); METABOLISM-GENL STUD,METAB PATHW{ I 3002); CARDIOVASC SYST-GENL STUDS,METHS(14501); CARDIOVASC SYST-HEART PAIHOLOGY{ 14 506); PHARMACOL-GENERAL STUD IES( *22002): PHARMACO- L-DRUG METAB,METAB STIMU(*22003); PHARMACOL-CL INICAL PI 1ARMACOL(2 2005): PHARMACOL-CARD I OVASC SYST(22010): ROUTES OF IMMUNIZ.INFECT,THERAP(22100) B1osystemat1c Codes: HOMINIDAE(86215). (c. BIOSIS 1982) (Item 127 of 858) User 3614 25jan83 2023 LEC{*10506); BIOPHYS-BIOCYBERNETICS(10515); METABOL1SM-GENL STUD,METAB PATHW( * 13002): METABOLISM-NUCL ACD,PUR INS.PYRIM( 1 - 30 14): DIGESTIVE SYST-PATHOLOGY( * 14006); TOX I COL -GENL/EXP STUDS,METHS(*22501): NEOPLSMS/NEOPL AGNTS-CARCINOGENS(24007 ) ; BACTERIAL AND VIRAL GENET ICS(* 31500): MED/CLIN MICROSIOL-BACTERIOLOGY(36002) Blosystemat1c Codes: ENTEROBACTEflrACEAE(048IO): HOMINIDAE(8- 6215); MURIOAE(86375) 22043909 TUMORS IN PATIENTS WITH ANGIO SARCOMA OF THE LIVER. VI ANNA N d BUREAU OF ENVIRON. EPIDEMIOL. AND OCCUPATIONAL HEALTH, TOWER BUILD.. GOVERNOR NELSON A. ROCKEFELLER EMPIRE STATE PLAZA; ALBANY, NY 12237. ANN INTERN MED 9 5 (2). 1981. 185- 186. Coden: A IMEA Language: ENGLISH Descriptors: THORIUM DI OXIDE ARSENIC VINYL CHLORIDE CARCINOGEN FAMILY HISTORY OCCUPATION DIAGNOSIS THERAPY Concept Codes: GENET ICS/CYTOGENET-HUMAN(03500); BIOCHEM STUD-GENERAL( 10060); MINERALS( 10069); PATHOLOGY-DIAGNOSTIC( 1 2- 504 ); PATHOLQGY-THERAPY( 12512); DIGESTIVE SYST - PATHOLOGY( I 40- 06); CARDIOVASC SYST-BLO VESS PATHOL(* 14508); TOXI COL-ENVI RON- MNTL. INDUSTR{* 22506); NEOPLSMS/NEOPL AGNTS-DIAGNS METH(*24001) ; NEOPLSMS/NEOPL AGNTS-PATM.CL INIC(*2 4004 ); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); NEOPLSMS/NEOPL AGNTS-THERAP.AGNT(2- 4 008): PUB HEALTH-ADMINISTR.STATIST ICS(37010); ENVIRON HEALTH-OCCUPATNL HEALTH(37013): ENVIRON HEALTH-A IR,WATR.SL POI.LN( 370 15): EPIDEMIOL - ORGAN IC 0 I S , NEOP L A SMS ( * 3 7054 ) Blosys tema t1c Codes: HOMINI DAE(86215) 22049333 MECHANISMS OF VINYL CHLORIDE CARCINOGENICITY MUTAGENICITY. HATHWAY D E l.C.I. LIMITED, CENTRAL TOXICOLOGY LABORATORY, ALDERLEY PARK, CHESHIRE SK10 4Td. BR d CANCER 44 (4). 1981. 597-600. Coden: BdCAA Language: ENGLISH Descriptors: SALMONELLA-TYPHIMUR IUM RAT MOUSE HUMAN LIVER DEOXY AOENOSINE DEOXY CYTIDINE DNA MOLECULAR MODEL Concept Codes: MICROSCOPY-CYTOLOG,CYTOCHEM TECH{01054); CYTOLOGY/CYTOCHEM-ANIMAL{*02506}; GENETICS/CYTOGENET-GENL STU DIES (03502); GENETICS/CYTOGENET-ANIMAL(*03506); GENETICS/CYTO GENE T-HUMAN{03508); BIOCHEM STUD -GENERAt( 10060); BIOCHEM 138378 DIALOG Fi)e5: BIOSIS Previews 77-83/dan BA7502;RRM2402(See F I Ie55 ) (c. BIOSIS 1982) (Item 131 of 858) User 3614 25Jan83 2024 22043867 ALKYLATION OF DNA BY VINYL CHLORIDE METABOLITES FORMATION OF 7-N-2 OXOETHYL GUANINE. LAIB R d; GWINNER L M; BOLT H M PHARMAKOLOGISCHES INST. UNIV., ABTEI LUNG TOXIKOL., D-6500 MAINZ J. 1ST SYMPOSIUM OF THE SECTION OF EXPERIMENTAL CANCER RESEARCH (SEK) OF THE GERMAN CANCER SOCIETY, HEIDELBERG. WEST GERMANY, MARCH 11-13. 1981. 99 (3) . 1981. A33-A34. Language: ENGLISH Coden: dCROD Descriptors: ABSTRACT RAT LIVER CARCINOGEN RADIO LABEL CHROMATOGRAPHY SPECTROMETRY Concept Codes: GENL BIOL -SYMPOSI A,PROCDNGS,R EVW(00520 ) ; RADIATION BIOL-RADTN, ISOTOP TECH(06504); BIOCHEM METH-GENERAL - (10050): BIOCHEM STUD-GENERAL{10060): BIOCHEM STUO-NUCL ACD,PURNS,PYRM(10062); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-MOLECUL PROP,MACROMOLEC(* 10506); MOVEMENT(12 100); MET ABOLISM-GENL STUD,ME TAB PATHW(* 13002); METABOLISM-NUCL ACD,PUR INS,PYRIM{13014}; DIGESTIVE SYST-PHYSIOL,BIOCHEM(*140- 04); TOXICOL-GENL/EXP STUBS,METHS{* 22501 ) : NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007) Blosystemat1c Codes: MURIDAE(86375) 22043382 WHEN IS SCLERODERMA NOT SCLERODERMA? THE DIFFERENTIAL DIAGNOSIS OF PROGRESSIVE SYSTEMIC SCLEROSIS. RODNAN G P 985 SCAIF E HALL., UNIV. PITTSBURGH, DEP. MED., PITTSBURGH, PA. 15261. BULL RHEUM OIS 31 (2). 1981. 7-10. Coden: BRDIA Language: ENGLISH Descriptors: HUMAN PSEUDOSCLERODERMA SCLERO MYX EDEMA FIBROSIS SCLERO OERMATO MYOSITIS CONNECTIVE TISSUE DISEASE AGE PLAQUE THICKENING EOSINOPHILIC FASCIITIS INFLAMMATION HISTOLOGY IMMUNO PATHOLOGY VINYL CHLORIDE DISEASE BLEOMYCIN INDUCED FIBROSIS Concept Codes: MICROSCOPY-HISTOL,HISTOCHEM TECH(01056): CYTOLOGY/CYTOCHEM-HUMAN(02508); BIOCHEM STUD-PROTEINS.PEPTIOE- S.AMINO ACO(10064); BIOCHEM STUD-CARBONYDR.(10068); PATHOLOGY-COMPARAT IVE(* 12503); PATHOLOGY - INFLAMMATN.INFLAM DIS{* 12508): BLOOD/BODY FLDS-BLOOD CELL STUDS(15004 ) ; BLOOD/BOOY FLOS-BLD,LYM,RES PATH(15006); BLOOD/BODY FLOS-LYMPHAT TISS,RES(150OB); MUSCLE SYST-PATHOLOGY(M7506); INTEGUMENT SYST-PATHOLOGY(* 18506); NERVOUS SYST-PATHOLOGY(* 20- 506); TOXICOL-GENL/EXP STUDS.METHS(*22501): TOXICOL-ENVIRONMN- TL.INDUSTRf*22506): DEVELOPMNTL BIOL-GEN MORPHGENSIS{25508); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(*34508); ENVIRON HEALTH-OCCUP- ATNL HEALTH(37013) . Blosystematlc Codes: HOMINIDAE(862 15) PAYER SON LAB., MANCHESTER. CHR1STE HOSP. AND HOLT RADIUM [NSF.. 22ND ANNUAL GENERAL MEETING OF THE BRITISH ASSOCIATION FOR CANCER RESEARCH. KEELE. STAFFORDSHIRE. ENGLAND. APRIL 13-15. 1981. BR J CANCER 44 (2). 1981. 272. Coden: BJCAA Language: ENGLISH Descriptors: CARCINOGEN ABSTRACT ESCHERI CHI A-COL I DNA POLYMERASE I Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURNS.PYRM- (10062): BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACD(10064); REPLICATN,TRANSCRIPTN.TRANSLATNf * 10300); ENZYMES-PHYSIOLOGICAL STUDIESC * 10808); META80LISM-NUCL ACD,PUR I NS.PYRIM(* 13014); PHARMACOL-ORUG METAB,METAB ' ST I MU(*2 2003): TOXICOL-GENL/EXP STUDS.METHS(*2250!): NEOPLSMS/NEOPL AGNTS-CARC INOGENS( * 2 4007 ); BACTERIA-PHYSIOLOGY.BIOCHEMISTRY(*37000) B iosys temat(c Codes: ENTEROBACTERIACEAE(04 810) 22038187 EFFECTS OF UV IRRADIATION ON THE MUTAGENICITY OF MONOMERS. OUVERGER M; LAMBOTTE M; PONCELET F; MERC IER M LAB . BIOT OX I COL. . UCL 73.69, 1200 BRUSSELS, 10TH ANNUAL MEETING OF THE EUROPEAN ENVIRONMENTAL MUTAGEN SOCIETY. ATHENS. GREECE. SEPT. 14-19, 1980. MUTAT RES 85 (4). 1981. 243-244. Coden: MUREA Language: ENGLISH Descriptors: ABSTRACT HUMAN ANIMAL SALMONELLA-TYPHIMURIUM ESCHERICHIA-COL I ACRYLONITRILE VINYL CHLORIDE CARCINOGEN CYTOCHROME P-450 OCCUPATIONAL EXPOSURE AIR WATER FOOD FREE RADICAL MECHANISM Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520) ; MICROSCOPY-CYTOLOG.CYTOCHEM TECH(01054); GENET!CS/CYTOGENCT-G- ENL S T UDIE S(03 502): GENETICS/CYTOGENET-PLANT(03504) ; MATHEMAT IC BIOL/STATISTIC METH(04500): RAD I AT I ON BIOL-RADTN,I SOTOP TECH!06504); RADIATION BIOL-RADTN EFF,PROTECT(*06506): ECOLOGY-B!OCLIMATOL.BIOMETEOROL(07504); ECOLOGY-LIMNOLQGY(07514); BIOCHEM STUD-GENESAL( 10060): BIOCHEM STUO-PROTEINS.PEPTIDES.AMINO ACO(10064); BIOCHEM STUD-PORPHYR- NS,BILE PIGM{ 10065): BIOPHYS-MOLECUL PROP,MACROMOLECt* 10506); ENZYMES-PHYSIOLOGICAL STUDIES< * 10808) ; METABOLISM-GENL STUD.METAB PATHW(* 13002); NUTRITION-PATHOGENIC DIETS( 132 16): TOXICOL-FOOD,RE SIDS.ADD IT.PRESRV(22502); TOXICOL-ENVIRONMNTL.INDUSTR(* 2 2 506); NEOPLSMS/NEOPL AGNTS-CAR- CINOGENSt*24007); BACTERIAL AND VIRAL GENET ICS(* 31500): MEO/CLIN MICROBIOL-BACTER10LOGY(36002): PUB HEALTH-ADMINISTR,- STATISTICS{37010); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-AIR,WATR.SL POLLN(37015); EPIDEMIOL-ORGAN IC DIS.NEOPLASMS(* 37054 ) Blosys tema tIc Codes: ENTER08ACTERI ACEAE(04810); VERTEBRATA-- UNSPECIFI ED(85 150); HOMINI DAE(86215) 22038222 CHLORO ACETALDEHYDE ERRORS DURING IN-VITRO HA t 1 J A * cappmt l l n A DNA VINYL CHLORIDE SYNTHESIS. METABOLITE INDUCES is 8379 DIALOG F11e5: BI05IS Prev 1 ews, 77-83/Jan BA7502;RRM2402(See F ___ dlOSIS 1982) (Item 135 of 858) User 3614 25Jnn83 2025 2 203 7 3 17 ISOLATION OF GUANINE DERIVATIVE IN THE REACTION OF CHLORO ACETALDEHYDE WITH DNA IN-VITRO. DOERJER G; OESCH F PHARMAKOLOGISCHES INSTITUT. ABT. MOLEKULAR-PHARMAKOLOGIE. OBERE ZAHLBACHER STRASSE 67. 0-6500 MAINZ. 1ST SYMPOSIUM OF THE SECTION OF EXPERIMENTAL CANCER RESEARCH (SEK) OF THE GERMAN CANCER SOCIETY, HEIDELBERG, WEST GERMANY. MARCH H-13, 1981. 99 (3)..1981. A2A. Coden: OCROD Language: ENGL ISH Descriptors: ABSTRACT VINYL CHLORIDE CARCINOGEN REACTIVE METABOLITE MUTAGEN Concept Codes: GENL BIOL -SYMPOSI A,PROCDNGS.REVW(00520): CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENETICS/CYTOGENET-ANIMAL(*03506); 8I0CHEM STUO - GENERAL(* 1006 0); BIOCHEM STUO-NUCL ACD,PURNS,PYRM(* 10062); REPLICATN.TRANS- CRIPTN.TRANSLATNt10300); BIOPHYS-MOLECUL PROP,MACROMOLEC(i0506); MET ABOLISM-GENL STUD,METAB PATHW( 13002): TOXI COL-GENL/EXP STUDS.METHSt*2250 1 ); NEOPLSMS/NEOPL AGNTS-CARCINOGENS{2A007); IN VITRO STUDS-CELLULR,SU8CELL(3 2600) Bfosysterna tic Codes: ANIMALIA-UNSPECIFIED(33000) 220352A9 HEPATO SPLENOMEGALY SECONDARY TO FOREIGN BODY REACTION IN PATIENTS ON MAINTENANCE HEMO DIALYSIS. BOMMER d; KREMPIEN B; RITZ E DEP. INTERN. MED., UNIV. OF HEIDELBERG, FRG. THE SOCIETY OF NEPHROLOGY, GERMAN SPEAKING, WUERZBURG. WEST GERMANY, OCT. 19-22. 1980. KIDNEY INT 20 (1). 1981. 144. Coden: KOYIA Language: ENGLISH Descriptors: ABSTRACT NONGRANULOMATOUS REACTION POLY VINYL CHLORIDE TUBING Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00520); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-BIOENGINEERING(1- 0511); MOVEMENT( 12100); DIGESTIVE SYST-PATHOLOGY(* 14006): BLOOD/BOOY FLOS-GENL STUDS,METHS(* 15001); FLDS-LYMPHAT TISS,RES(15008) BLOOD/BOOY Blosystemat1c Codes: HOMINIDAE{86215) 22034799 THE NEPHRO TOXICITY OF LOW MOLECULAR WEIGHT HALOGENATED ALKANE SOLVENTS PESTICIDES AND CHEMICAL INTERMEDIATES KLUWE W M NATL. INST. ENVIRON. HEALTH SCI., RESEARCH TRIANGLE PARK. N.C. 27709. HOOK. J, B. (ED.). TARGET ORGAN TOXICOLOGY SERIES: TOXICOLOGY OF THE KIDNEY. XII+276P. RAVEN PRESS: NEW YORK. N.Y., USA. ILLUS. ISBN 0-89004-475-9. O (0). 1981. P 179-226. Coden: 11114 Language ENGLI SH Descriptors: REVIEW RAT MOUSE ANIMALS HUMAN 1 3 DI CHLORO PROPENE TRI CHLORO ETHANE PER CHLORO ETHYLENE CARBON TETRA BROMOCHLORO PROPANE CARCINOGEN NEPHROPATHY ENVIRONMENTAL POLLUTION VINYDDENE CHLORIDE VINYL CHLORIDE CHLORO PHENE HEXA CHLORO BUTADIENE ETHYLENE Dl BROMIDE Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520): BIOCHEM STUD-GENERAL{ 10060); BIOPHYS-MOLECUL PRDP.MACROMOLEC( - 10506): URIN SYST/EXT SECR-PATHOLOGY( * 15506 ) : TOX I COL-GENL/EXP STUOS .METHS(*22501); TOXI COL-ENVIRONMNTL.INDUSTR(*22506); NEO PLSMS/NEOPL AGNTS-CARCI NOGENS(*2 4007); ENVIRON HEALTH-A IR.WAT- R,SL POLLN(*37015): PEST CONTRL GENL/PESTICS/HERB ICS(*54 600) Blosystemat1c Codes: VERTEBRAEA-UNSPECIFI ED(85150); MUR I D A E (86375) 22034120 DETERMINATION OF LEVEL OF MIGRATION INTO WATER OF THE PLASTICIZERS DIOCTYL PHTHALATE DI ALKYL PHTHALATE 789 AND DI ALKYL PHTHALATE 68 FROM POLY VINYL CHLORIDE MATERIALS KATAEVA S E KIEV INST. POSTGRAD. MED.. MINIST. HEALTH USSR. KIEV. USSR. GIG SANIT 0 (5). 1980. 82-83. Coden: GISAA Language: RUSSIAN Descriptors: NOTE WATER POLLUTION Concept Codes: ECOLOGY-GENL STUD IES,METHODS(07502) : ECOLOGY-WATR RESRCH,FISHERY BI0L(07517): COMPARATIVE BIOCHEM-GENL STUD IES( 10010); BIOCHEM METH-GENERAL( 10050); BIOCHEM STUO-GENERAL( 10060): TOXI COL-ENVIRONMNTL,INDUSTR{22506): ENVIRON HEALTH-AIR,WATR.SL POLLN{* 370 1 5 ) 22033706 A NEW TYPE OF DRAIN TUBE SUGITACIH A; TANAKA M; KAWAHARA T; KITAMURA N; TAKAGI K DEP. SURG.. OSAKA NATL. HOSP., OSAKA 540, UPN. 3R0 ANNUAL MEETING OF THE INTERNATIONAL SOCIETY FOR ARTIFICIAL ORGANS, PARIS. FRANCE, JULY 8-10. 1901. ARTIF ORGANS (CLEVELAND) 5A (0). 1981. 69. Coden: ARQRD Language: ENGLISH Descriptors: ABSTRACT HUMAN URO KINASE HEMATOLOGIC-DRUG POLY VINYL CHLORIDE TUBE ANTI THROMBOGENICITY Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS,REVW(005 20) ; BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACO(10064); BiOPHYS-BIOE NGINE E R 1 NG {* 1 05 1 1 ) ; ENZYMES-PHY SIOLOGICAL STUOIE S( * 10808 ) ; PHYSIOLOGY-METHODS(* 12006); PATHOLOGY - THERAPY( 12512): CARO 10V- ASC SYST-BLD VESS PATHOL{* 1450B); PHARMACOL-CL INI CAL PHARMACOL(2 2005); PHARMACOL -BLOOD,HEMAT0 AGENTS( *2 2008 ) B I osystemat1c Codes: HOMINIOAE(862 1 5 ) DIALOG e5: BIOSIS Previews 77-83/dan BA75U2 ; RRM2402 ( Sw fm. R&S 138380 22030899 MAKING POLY VINYL CHLORIDE COLORED LEG BANDS ANDERSON A CULTERTY FIELD STATION, DEP. ZOOL., UNIV. ABERDEEN NEWBURGH, ELLON, ABERDEENSHIRE AB4 OAA, UNITED KINGDOM, d WILDL MANAGE 45 (4). 1981. Language: ENGL ISH 1067-1068. Coden: dWMAA Descriptors: BIRD Concept Codes: GENERAL FIELD METHODS(0 1008); GENERAL FIELD APPARATUS**010)0); ECOLOGY-ANIMAL(*07 508); ECOLOGY-TERRESTRI AL WILDLIFE MGMT(*07518); CHORDATE TAXONOMY-AVES(*625 18 ) Blosystemat1c Codes: AVES-UNSPEC1FI ED(85500) 22023088 HYGIENIC EVALUATION OF AIR POLLUTION CONTROL MEASURES IMPLEMENTED AT FACTORIES MANUFACTURING VINYL CHLORIDE AND POLY VINYL CHLORIDE TIKHOMIROV YU P; GULKHOV S P: KUZNETSOVA L V; IL'ICHEVA G V; KALENT'EV V N GORKI RES. INST. IND. HYG.-OCCUP. DIS., GORKI. USSR. GIG SANIT O (10). GI S A A 1980 (RECD. 1981). 79-81. Coden: Language: RUSSIAN Descriptors: NOTE HUMAN Concept Codes: BIOCHEM-GASES(10012); BIOCHEM STUD-GENERAL( 1- 0060): PATHOLOGY-GENERAL STUD IES( 12502); PATHOLOGY-COMPARATI V- E ( 12503); METABOLISM-GENL STUD , MET AB PATHW{ 13002); TOXICOL-ENVIRONMNTL,INDUSTRf*22506): ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-A IR.WATR,SL POLLN(37015) B losy sterna t 1c Codes : HOMINI DA ( 862 15) 22023084 SOME ASPECTS OF THE IMPLEMENTATION OF SANITARY SURVEILLANCE IN THE CONSTRUCTION INDUSTRY ZOLKIN G A ALL-UNION RES. DES. INST. WORK CONSTRUCT.. OFF. STATE CONSTR. USSR, MOSCOW, USSR. GIG SANIT GI SAA 0 (10). 1980 (RECD. 1981). 65-66. Coden: Language: RUSS I AN Descriptors: NOTE HUMAN POLY VINYL CHLORIDE DUST Concept Codes: SOCIAL BIOL/I IUMAN ECOLOGY(05500); BIOCHEM-GASES( 10012); BIOCHEM STUO-GENERAL( 10060): PATHOLOGY-- GENERAL STUOIESC 12502) ; METABOLISM-GENL STUD,ME T AB PATHWt13002); TOXICOL-ENVIRONMNTL,INDUSTR(*22506); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-A IR.WATR.SL POLLN**37015) B1osysterna t1c Codes: HOMINIOAE(86215) {c. BIOSIS 1982) (Item 140 of 858) User 3614 25Jai 2026 LAUWERYS R; OE COOMAN S DEP. MED. HYG. TRAVAIL, U.C.L., 30.54. CLOS CHAPELLE-AUX-CHAMPS, B-1200 BRUXELLES. LOUV MED 100 (4). 19B1. 197-203. Coden: LOMEA Language: FRENCH Descriptors: HUMAN ANIMAL PESTICIDE BORON CADMIUM LE AO MANGANESE POLY BROMINATEO BI PHENYL VINYL CHLORIDE DICHIORVOS CARBARYL VOLATILE ANESTHETIC EMBRYO TOXICITY OCCUPATIONAL HEALTH INSECTICIDE Concept Codes: 8 IOCHEM-GASES( lOO12): BIOCHEM STUD-GENERAL( 1 - 0060); MINERALS* 10069); PATHOLOGY -COMPARATIVE( 12 503); METABOLISM-GENL STUD,MET AB PATHW{ 13002); MINERALS( 13010); REPRODUCT SY ST-PATHOLOGY(* 16506) : PHARMACOL-NEUROPHARMACOLOGY- ( *2 202 4 ): TOXICOL-PHARMACOLOGICAL(*22504 ); TOXI COL-ENVIRONMNT- L.INDUSTR( *22506); DEVELOPMNTL BIOL-PATHOLOGICAL( * 25503); OEVELOPMNTL BIOL-GEN MORPHGENS IS(25508); DEVELOPMNTL BIOL-DE SCR IP TERATOL(*25552 ) ; ENVIRON HEALTH-OCCUPATNL HEALTH**370 13) : ENVIRON HEALTH-A IR.WATR.SL POLLN(* 37015 ) : PEST CONTRL GENL/PESTICS/HERBICS(*54 600); ECDNOM ENTOMOL-CHEM PHYS CONTRLf 60016) Biosystemot1c Codes: VERTEBRATA-UNSPECIFIED(85150); HOMINID- AE(86215); ABSTRACTS OF ENTOMOLOGY(96000) 22014582 IN-VITRO TRANSFORMATION OF HAMSTER EMBRYO CELLS EXPOSED TO GASEOUS OR VOLATILE CHLORINATED HYDRO CARBONS HATCH G G: MAMAY P D; CHRISTENSON C C; CASIO 8 C; LANGENBACH R; NESNOW S NORTHROP SERV. . INC. . US ENVIRON. PROT . AGENCY, RESEARCH TRIANGLE PARK, N.C. 72ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. INC., WASHINGTON. D.C.. USA. APRIL 27-30. 1981. PROC AM ASSOC CANCER RES AM SOC CLIN ONCOL Coden: PAAOD 22 (O). 1981. 119. Language: ENGL 1SH Descriptors: ABSTRACT SA-7 VIRUS 1 1 1 TRI CHLORO ETHANE 01 CHLORO METHANE I 1 DI CHLORO ETHANE 1 2 DI CHLORO ETHANE VINYL CHLORIDE CARCINOGEN Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(005 20 ) ; CYTOLOGY/C Y T OCHEM-ANIMAL(* 02 506); B IOCHEM-GASES( tOO12); BIOCH EM STUD-GENERAL(10060); PHARMACOL-DRUG METAB.METAB ST I MU(* 2 2003); TOXICOL -GENL/EXP STUDS,METHS(*2 2501}; NEOPLSMS- /NEOPL AGNTS-CARCINOGENS( *24007 )'; DEVELOPMNTL BIOL-EXPER TERAIOI. ( *25554 ) ; MED/CLIN MI CROC I OL - VI ROLOG Y ( *36006) BlosystematIc Codes: ADENOVIRIOAE(02210); CRICETIOAE(86310) 22017151 RISK FOR CHEMICALS TESTICULAR FUNCTION ELICITED BY SOME INDUSTRIAL R&S 138381 DIALOG FileS: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See F11e55) (c. BIOSIS 1982) (Item 145 of 858) User 3614 25Jan83 2027 22013384 VINYL CHLORIDE AN EXAMPLE FOR EVALUATING MUTAGENIC EFFECTS IN MAMMALS IN-VIVO AFTER EXPOSURE TO INHALATION BASLER A; ROEHRBORN G INST. HUMANGENET. ANTHROPOL., UNIV., 0-4000 DUESSELFORF 1. 10TH ANNUAL MEETING OF THE EUROPEAN ENVIRONMENTAL MUTAGEN SOCIETY, ATHENS, GREECE, SEPT. 14-19, I960. MUTAT RES 85 (4). 1981. 240. Coden: MUREA Language: ENGLISH Descriptors: ABSTRACT CHINESE HAMSTER Concept Codes: GENL BIOL-SYMPOSIA.PROCONGS,REVW(00520); CYTOLOGY/CYTOCHEM-ANIMAL(*02506); GENET ICS/CYTOGENET-ANIMAL(*03506); BIOCHEM STUD-GENERALI 10060) ; BLODD/BOOY FLDS-BLOOD CELL STUDSt15004 ) ; BLOOD/BODY FLDS-LYMPHAT TISS.RES( 15008); BONE,UNTS.FASC.CONN/AO IP-GENL( 18001); TOXICOL-GENL/EXP STUDS,METHS(* 22501) Bfosystemat1c Codes: MAMMAL IA-UNSPECIFI ED AND EXT INCT(85700) ; CRICTIDAE(86310) 22011500 DNA ALKYLATION BY VINYL CHLORIDE METABOLITES ETHENO DERIVATIVES OF 7 ALKYLATION OF GUANINE LA IB R J PHARMAKOL. INST. DER UNIV., ABTEI LUNG TOXIKOL., D-6500 MAINZ t. 22ND SPRING MEETING OF THE DEUTSCHE PHARMAKOLOGISCHE GESELLSCHAFT (GERMAN PHARMACOLOGICAL SOCIETY), MAINZ, WEST GERMANY, MARCH 10-13, 198 1. PHARMACOL 316 (SUPPL.). 1981. Language: ENGLISH NAUNYN-SCUM IEDEBERG'S R13. Coden: NSAPC ARCH Descriptors: ABSTRACT RAT LIVER MICROSOMES CARCINOGENICITY Concept Codes: GENL 8IOL-SYMPOSIA,PROCONGS.REVW(00520); CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENET ICS/CYTOGENET-ANIMAL(*03506); COMPARATIVE BIOCHEM-GENL STUDIES(10010); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURNS.PYRM(10062): REPL ICATN,TRANSCRIPTN.TRANSLATN(10300); BIOPHYS-MOLECUL PROP,MACROMOLEC(10506); METABOLISM-NUCL ACO.PURINS,PYRIM(* 13014); DIGESTIVE SYST-PHYSIOL. EU OCHEM(1400- 4); TOXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPL AGNTS-CARCINOGENS{* 2 4007); IN VITRO STUDS-CELLULR,SUBCELL(326OO) 0losystematic Codns; MURIOAE(86375) BIOCHEM STUO-GENERAL(10060); BIOCHEM STUD-PROTE[NS,PEPTI 0ES.A - MINO ACD( 10064); BIOCHEM STUO-CARBOHYDR.( 10060); PATHOLOGY-GE- NERAL STUOIESC 12502); PATHOLOGY-COMPARAT IVE( 12503) ; PATHOLOGY- -OIAGNOSTIC( 12504); METABOLISM-GENL STUD.METAB PATHW{ 13002) ; METABOLISM-CARBOHYDRATES(13004); METABOLISM-PROTNS,PEPTOS.AM ACDS( 13012); DIGESTIVE SYST-PATHOLOGY(* 14006); CARDIOVASC SYST-BLD VESS PATHOL(* 14508); BLOOD/BODY F LOS -GENL STUDS.METHSt 15001 ) ; BLOOD/BODY FLDS-BLOOD.LYMPH STUO(* 15002 ) ; BONE.dNTS,FASC.CONN/ADIP-PATHOL(* 18006); INTEGUMENT SYST-PATH- OLOGYf* 18506); TOXICOL-ENVIRONMNTL. INOUSTR(* 22506); NEOPLSMS/- NEOPL AGNT S-CARC I NOGENS ( 24007 ) : I MMUNO L / I MMUNOCHEM-. IMMUNOP A TH - OL(* 34 508); ENVIRON HEALTH-OCCUPATNL HEALTH( *37013) ; ENVIRON HEALTH-AIR.WATR.SL POLLN(*37015) B iosystematic Codes: HOMINIDAE(86215} 22004922 UTILIZATION OF POLYMERIC MATERIALS BY FUNGI ORLOVA E I V.L. KOMAROV BOT. INST.. ACAD. SCI. USSR, LENINGRAD. USSR. MIKOL FITOPATOL Coden: MIFIB 14 (5). 1980 (RECD. 1981). 422-425. Language: RUSSIAN Descriptors: ASPERGILLUS-FLAVUS ASPERGILLUS-NIGER PENICILLI- UM-FUNICULOSUM AUREOBASIDIUM-PULLULANS POLY ETHYLENE POLY VINYL CHLORIDE FUNGICIDE NEMATOCIDE BIOCIDE INSECTICIDE Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOPHYS-MOLECUL PROP.MACROMOLEC{ 10506); METABOLISM-GENL STUD.ME T AB PATHW(*130- 02): PLANT PHYSIOL-METABOLISM(*51519); PEST CONIRL GENL/PEST I CS/HF.RB ICS ( *54600) Blosystemat1c Codes: DEUTEROMYCETES(15500}: ABSTRACTS OF MYCOLOGY(95000): ABSTRACTS OF ENTOMOLOGY(96000) 22011433 SOME INDICES OF SERUM IN WORKERS EXPOSED TO VINYL CHLORIDE ANTOV G P; SPASOVSKI M KH INST. HYG. OCCUP. MEO., SOFIA, BULG. GIG .TR PROF ZABOL 0 (8). 1980. 47-48. Coden: GTPZA Language; RUSSIAN Descriptors: NOTE VASCULAR PATHOLOGY FIBROSIS SCLERODERMA LIVER COLLAGEN GLYCO PROTEIN OXY PROLINE Concept Codes: CLIN BIOCHEM-GENL STUOIES(* 10006); COMPARATIVE BIOCHEM-GENL.STUDIES{1OO10); BIOCHEM METH-PROTNS.- PEPinS AM nr ( * fOOR'l 1 nrn>~t|i->. .. ...........................................------ R&S 138382 DIALOG Ftle5: BIOSIS Previews 77-83/dan BA7502;RRM2402 ( See MSe55) (c. BIOSIS 1982) (Item 149 of 858) User 3614 25jan83 2028 72084705 INVESTIGATIONS ON THE CORRELATION BETWEEN VINYL CHLORIDE UPTAKE AND EXCRETION OF ITS METABOLITES BY 15 VINYL CHLORIDE EXPOSED WORKERS 1. MEASUREMENTS OF THE INDIVIDUAL VINYL CHLORIDE EXPOSURE BY MEANS OF STATIONARY MONITORING AND PERSONAL AIR SAMPLING HEGER M; MUELLER G; NORPOTH K INST. FUER STAUBLUNGENFORSCHUNG AND ARVEITSHED171N DER WESTFAELISCHEN WILHELMS-UNIV. MUENSTER, WESTRING 10. 0-4400 MUENSTER, BUNDESREPUBLIK DEUTSCHLAND. INT ARCH OCCUP ENVIRON HEALTH Coden: IA0HD 48 (2). 198J. 205-210. Language: GERMAN Vinyl chloride (VCM) exposure of 15 workers was determined by statlonary non 1 toning and persona 1 air sampling. The mean value obtained by stationary measurements was 4.51 . + -. 0.67 ppm and that from personal related measurements was 6.03 .+-. 5.04 ppm, both referring to a mean air concentration during a 12-h work period. S ta t1onary. measurement values ranged 3.5-5.8 ppm and persona 1 related measurements were 0.3-18.4 ppm. Analytical data of the 2 series were not correlated. Stallonary mon1 tor 1ng might be consIdered as sufficient for the risk control of VCM exposed collectives. Persona 1 air monitoring Is necessary for Investigations concerning the dependence of the excretion of VCM metabolites from VCM uptake. Descriptors: HUMAN Concept Codes: GENERAL FIELD METH0DS(01008); GENERAL FIELD APPARATUS(OtOIO); SOCIAL BIOL/HUMAN ECOLOGY(05500): 8 IOCHEM-GASES(10012); BIOCHEM METH-GENERAL{*10050): BIOCHEM STUO-GENERAL{10060): BIOPHYS-BIOENGINEERING(1051t); PATHOLOGY- -DIAGNOSTIC( 12504); METABOLISM-GENL STUD.MET AB PATHW{13002): TOXI COL-ENVIRONMNT L,INDUS7R(* 22506): NEOPLSMS/NEOPL AGNTS-CAR- CINOGENS(* 2 4007); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013): ENVIRON HEALTH-AIR,WATR.SL POLLN(*37015) B1osystemat1c Codes: HOMINIDAE(862 15) Descriptors: HUMAN HYDRO CARBON ETHYLENE PROPYLENE VINYLl CHLORIDE TRI CHLORO ETHYLENE METHYL METHACRYLATE Concept Codes: BEHAVIOR BIOL-HUMAN BEHAVI OR(07004}; BIOCHEM STUD-GENERAL( 10060); BIDPHYS-GENERAL BIOPHYS TECH( 10504 ) ; PATHOLOGY -COMPAR AT IVE{ 12503); PATHOLOGY-DIAGNOSTIC{ 12504); MET ABOLISM-GENL STUD.METAB PATHW( 13002); NERVOUS SYST-GENL STUDS,METHS(20501): NERVOUS SYST-PATHOLOGY{*20506) : PSYCHIATR- Y-PSYCHPATH-OYNM.THERAP(*21002): TOXICOL-ENVIRONMNTL,INOUSTR(22506); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-A IR.WATR,SL POLLN(* 37015 ) B losystemat1c Codes: HOMINIDAE(862 15) 72075304 CALCIUM II SELECTIVE ELECTRODES A NOVEL POLY VINYL CHLORIDE GELLED NEUTRAL CARRIER MIXTURE COMPARED WITH OTHER CURRENTLY AVAILABLE SENSORS/ TSIEN R Y: RINK T d PHYSIOL. LAB., UNIV. OF CAMBRIDGE, CAMBRIDGE CB2 3EG, ENGL.. UK . J NEUROSCI METHODS Language: ENGLISH 4 {1). 1981. 73-86. Codon: JNM^O The gr*ea t l mpor tance of cytoplasmic free Ca2 * In regulating collular function has stimulated the deve1opment of several more-or-less Ca-selectlve sensor systems for microelectrodes. The known formulatIons each have serious deficiencies, particularly In fine mlcroelect rodes. A new sensor was deve1 oped wh1ch gives distinctly Improved performance of subraleron tips. This sensor comb Ines the widely used neutral carrier ETH1001 with an Intensely hydrophob fc salt Into a polyvinylchloride gel. This study compares the calibration responses of the various sensor systems under a uniform set of experimen ta 1 cond1tIons. Concept. Codes: GENERAL LABORATORY APPARATUS(01006); MICROSCOPY-CYTOLOG.CYTOCHEM TECH{0 1054) ; MINERALS( * 10069) ; NERVOUS SYST-GENL STUDS,METHS(*20501) 72077527 PATHOGENESIS OF DYSSOMNIA IN SOME OCCUPATIONAL NEURO TOXICOSES AS REVEALEO BY POLYGRAPHIC RECORDING OF NIGHT SLEEP GNESINA E A; ANTONYUZHENKO V A INST. INO. HYG. OCCUP. DIS-. GORKI, USSR. GIG TR PROF ZABOL O (9). 1980 (RECD. 1981). 10-13. Coden: GTPZA Language: RUSSIAN Continuous polygraphIc record tng of night sieep was done on 22 patients with chronic occupational Intoxication by narcotic substnnees such as tow MW hydrocarbons and tbolr chlorine derivatives (ethylene, propylene, vinyl chloride, tr1 chioroethy1ene) and In 8 patients with Intoxication by methyl methacrylate. Analysis established the realtionshlp between levels of funct1 on of the activating and hypnogen1c systems. A dyssomn1 a syndrome evolved In phases which correlated with .the stages of Intoxication. and the phas 1 c nature of the syndrome was accounted for by nonuniformity of R&S 138383 DIALOG File5: BIOSIS Previews 77-83/dan BA7502:RRM2402 t See F 1 1e55) (c. BIOSIS 1982) (I tern 152 of 858) User 3614 2Sjan83 2029 72074838 MODIFICATION OF DEOXY GUANOSINE BY CHLORO ETHYLENE OXIDE SCHERER E; VAN DER LAKEN C J; GWINNER L M; LAIB R d: EMMELOT P DIV. OF CHEMICAL CARCINOGENESIS, ANTONI VAN LEEUWENHOEK-HUIS. THE NETHERLANDS CANCER INST,. 121 PLESMANLAAN, 1066 CX AMSTERDAM, THE NETHERLANDS. CARCINOGENESIS (LOND) CRNGO 2 (7). 1981. 671-678, Cgden: Language: ENGLISH Reaction of deoxyguanos1ne In glacial acetic acid with ch1oroethy 1ene oxide, a proposed reactive metabolite of vinyl chloride, led to a single, strongly fluorescent product In nearly quantitative yield. The UV spectra Indicated alkylation of N-7 of guanine, which was confirmed following reduction of the reac 11 on product by sodium borohydrIde to 7-(2-hydroxyethyl)guan1ne, and the synthesis of the same modified guanine via a stereoselective 7-N hydroxy alkylation using 2-. 3-epoxy-1-propanol . In agreement with the expected structure 7-(2-oxoethy1)guanine reacted with the carbonyl specific reagent 2,4-dinftropheny1hydraz1ne (2.4-DNPH), Its IR and proton NMR spectra did not support the existence of a simple aldehyde group. The 2.4-d1nitropheny1hydrazone was labile. 7-(2-oxoethy1)guan1ne being produced when excess 2,4-DNPH was removed. This Instability was interpreted as being due to the reversible formation of a hemlacetal ring between 06 of the guanine residue and the aldehyde carbon of the 2-oxoalkyl group resulting in 06,7 -(1'-hydroxyethano ) guan ine. This conformation was supported by the occurrence In field desorption mass spectra of the ions of m/e = 175 and 292 which are 1nterpreted as 06,7-e thenoguan t ne and 06.7-ethenodeoxyguanosine resulting from the elimination of H2D of the hydroxyethano residue. 06.7-(t'-hydroxyethano)guan- 1ne might be expected to cause faulty base pairing during replication of DNA, which may be the molecular basis of the carcinogenicity of vinyl chloride. Descriptors: REPLICATION VINYL CHLORIDE CARCINOGEN MUTAGEN DNA Concept Codes: GENET ICS/CYTOGENET-GENL STUDIESi*03502): BIOCHEM METH-GENERAL( 10050) ; BIDCHEM STUD-GENERAL'{ 10060 ) ; BIOCHEM STUO-NUCL ACD.PURNS.PYRM( 10062); 8I0PHYS-GENERAL 8I0PHYS TECH(10504): METABDLISM-GENL STUD,META8 PATHW(*t3002); METABOLISM-PROTNS,PEPTDS.AM AC0S(* 13012); TOXI COL-GENL/EXP STUDS.METMSi* 22501); NEOPLSMS/NEOPL AGNTS-CARCINOGENS{*24007) cInnnnon1tr1 Io to rats, 2 typos of morcopUirIc acids wore Isolated from urine and identified by mass and NMR spectroscopy as N-acety1 -S-(2-cyanoethy1 )-L-cyste1ne (I) and N-acetyl-S-{2-hydroxyethy1)-L-cysteine (II) (methyl-substitut ed (n the case of crotonltrlle and pheny1 - subst1tuted In the case of cInnamon1tr11e). After pretreatment of rats with the cytochrome P-450 Inhibitor 1-pheny11m1dazole, no trace of mercapturic acid II was found; a higher amount of mercapturic acid I was excreted. The 1st type of products may result from d i rec t add 111 on of glutathlone: t he 2nd group of met abo 1 1t es (II), In which the cyano group has been replaced by a hydroxyl group, may be Tormed via an Intermediate epoxide. Substituents on the double bond had a considerable Influence on the ratio of the 2 mercapturic acids formed. and thus presumably on the amount me t abo1 lz ed via an ox I da five process : t he ratio of the cyano (I) to hydroxy (II) mercapturic acid was 72:28 for AN; Introduction of a methyl or a phenyl group resulted in ratios of 91:9 and 98:2, respectively. [Acrylonitrile is an industrial mutagen structurally similar to the carcinogen vinyl chloride.) Descriptors: RAT MUTAGEN VINYL CHLORIDE CARCINOGEN 1 PHENYL IMIDAZOLE METABOLIC-DRUG GLUTATHIONE Concept Codes: GENET ICS/CYTOGENET-ANIMAL(*03506); COMPARATI VE BIOCHEM-GENL STUDIES( 10010); BIOCHEM METH-GENERAL( 10050) : BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-PROTEINS,PEPTIDES.A- MINO ACD( 100G4); B I OPHY S - C.E NE R AL BIGPHYS T ECH( (0504 ) ; ME TA80L1SM-GENL STUD,METAB PATHW(13002); METABOLISM-PROTNS.PEPTDS,AM ACDSt* 13012); URIN SYST/EXT SECR-PHYSL.BI0CHEM{ 15504j ; PHARMACOL-DRUG METAB.METAB STIMU{* 22003); TOXI COL-GENL/EXP STUDS,METHSI*22501 ); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007) BIosystemat1c Codes; MURIDAE(86375) 72073259 FORMATION OF MERCAPTURIC ACIDS FROM ACRYLONITRILE CROTONONITftlLE AND CINNAMONITRILE BY DIRECT CONJUGATION AND VIA AN INTERMEDIATE OXIDATION PROCESS' VAN BLADEREN P J; DELBRESSINE L P C; HOOGETERP J J: BEAUMONT A H G M; BREIMER 0 0; SEUTTER-BERLAGE F; VAN OER GEN A DEP. PHARMACOL., UNIV. LEIDEN, P.0, BOX 9502, 2300 RA LEIDEN, NETH. DRUG METAB DISPOS 9 (3). 1981. 246-249. Codon: OMDSA Language: ENGLISH After a dm l n i s t rn 11 on of ar-rv 1 on It'-ho ' DIALOG FHe5: BIOSIS Previews 77-83/Jan 8A7502 ; RRM2402 { See F I 1 e55 ) (c. BIOSIS 1982) R&S 138384 ... .jh or 858) User 36 14 25Jan83 2030 72071304 NEUTRAL CARRIER BASED ION SELECTIVE ELECTRODE FOR THE DETERMINATION OF SODIUM IN URINE JENNY H-8; AMMANN D; DOERIG R: MAGYAR B; ASPER R: SIMON W ETH-CENT-. . DEP. ORGANI C CHEM. . UNI VERS I T AETSSTRASSE 16. CH 8092 ZUERICH, SWITZERLAND. MIKROCHIM ACTA Coden: MIACA 2 (1-2). 1980 {RECO. 1981). 125-132. Language: ENGL ISH A Na+-se1ect1ve PVC[po!yv1nyIchlorIde]-membrane electrode wh1ch allows cont1nuous measurement of Nn+-act1v1t1es In undiluted urine samples Is described. In view of routine clinical analysis and bedside monitoring In Intensive care units, a miniaturized electrode system was developed. When the Na+-concentratIons determined by Ion selective electrodes are correlated with those obtained for the same samples via flame photometry and atomic absorption. the residual standard deviation is found to be range. 4.5 mM over the 50-250 mM Na+ Descriptors: HUMAN MINIATURIZED POLY VINYL CHLORIDE MEMBRANE ELECTRODE SYSTEM FLAME PHOTOMETRY ATOMIC ABSORPTION Concept Codes: BIOCHEM METH-MINERALS(* 10059); MINERALS( 1006- 9); BIOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHYS-BIOENGINEERI- NG(*10511); PATHOLOGY-DIAGNOSTIC( 12504); UR IN SYST/EXT SECR-GEN STUD.METH(* 15501): URIN SYST/EXT SECR-PHYSL.BIOCHEM{- 15504); URIN SYST/EXT SECR-PATHOLOGY(* 1 5506) Blosystemat1c Codes: HOMINIOAE{86215) 72070457 PROTECTIVE EFFECT OF METHIONINE AGAINST VINYL CHLORIDE MEDIATED DEPRESSION OF NONPROTEIN SULFHYDRYLS AND CYTOCHROME P-450 W1SNIEWSKA-KNYPL J M; SOKAL J A; KLIMCZAK J; DAJNIAK A; BOGOANIKOWA B INDUSTRIAL TOXICOL. BRANCH. INST. OCCUPATIONAL MED., TERESY 8. 90-950 LOOZ, POLAND. TOXICOL LETT (AMST) B (3). 1981. 147-152. Coden: TOLED Language: ENGLISH Potentiality of a protective effect of Mot against hepa to tox1c action of vinyl ch1 or 1de (VC) was assessed on rats, 1nduced with phenobarb1ta1 and then exposed to 50.000 ppm VC for 5 h. This high dosage of VC warranted the appearance of drastic symptoms of liver Injury In the course of 20 h postexposure. OL-Met at t g/kg given by gavage prior to VC-exposure counteracted VC-provoked depletion of non-protetn SH and destruction cytochrome P-450 In the liver. In Met pretreated rats the phenobarb 1 ta1 - 1nduced synthesis of microsomal proteins in the livers was maintained during the post-exposure period, contrary to the non-pretreated animals. It may be Justified to apply Met as a prophylactic agent In cases of occupational exposure to VC. Descriptors: HUMAN RAT ANTIDOTE METABDl. IC-DRUG PHENO BARBITAL LIVER MICROSOME KINETICS OCCUPATIONAL HEALTH Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); CYTOLOGY/CY- TOCHEM-HUMANf 02508): SOCIAL BIOL/HUMAN ECOLOGYJ05500); BIOCHEM STUO-GENERALI 10060) : RfOCHFM STIHi-Nliri am PilPMC hyijwI i one *> 1 111OCHEM STUO-PROTEINS.PEPTIDES.AMINO ACD( 10064 ); BIOCHEM STUD -PORPHY RNS.BILE PIGM( 10065); ENZYMES-GEN.COMPAR STUO.COEN- ZYMS{* 10802) ; ENZYMES-PHYSIOLOGI CAL STUD IES(*10808); ANATOMY/- HISTOL-MICRO.ULTRAMICRSC(11108): PATHOLOGY - THERAPY( 12512); METABOLISM-GENL STUO.METAB PATHW(* 13002): METABOLISM-PROTNS.P- EPTOS.AM ACDS{ 130 12 ) ; METABOLISM-PORPHYRINS,BILE PIGMN(*1301- 3); MET ABOL I SM-NIJCL ACD . PUR I NS , P Y RIM ( * 1 30 14); DIGESTIVE SYST-GENL STUDS.METHS(14001): DIGESTIVE SVST-PATHOLOGY(*14006) ; PHARMACOL-DRUG METAB.METAB ST IMU( *22003): PHARMACOL-CLINICAL PHARMACOL(22005): ROUTES OF IMMUNIZ.INFECT.THERAP{221OO): TOXICOL-PHARMACOLOGICALt *22504); TOXICOL-ANTIDOTES,PREVENT IVE{*22505); T OX ICOL-ENVIRONMNT L,INDUS T R( 2 2 506) ; NEOPLSMS/NEOPL AGNTS-CAR- CINOGENS(24007); ENVIRON ' HEALTH-OCCUPATNL HEALTH! *37013); ENVIRON HEALTH-AIR,WATR.SL POLLN(*37015) Blosystemat1C Codes: HOMINIDAE(86215 } ; MUR I DAE(86375 ) 72070028 EPIDEMIOLOGY OF ANGIO SARCOMA OF LIVER IN NEW-YORK STATE USA VI ANNA N J; BRADY J A; CARDAMONE A T N.Y. STATE DEP. HEALTH, BUREAU ENVIRON. OCCUPATIONAL HEALTH, ALBANY, N.Y. EPIDEMIOL. N Y STATE J MED 81 (6). 1981. 895-899. Coden: NYSJA Language: ENGLISH The geographic distribution of ASL (angiosarcoma of the liver) among residents of New York, USA, was examined with special emphasis on the epidemiologic character 1st les which might be of etlologlc Importance In this malignancy. The average annua 1 Incidence rate for the state. exc!udIng New York City. was 0.26 per million population. Of the chemicals associated with ASL. potential exposure to vinyl chloride appeared to be the most Important factor In certain urban Industrialized counties, whereas probable arsenic exposure was the major factor in rural areas. Prior thorium dioxide Injections accounted for only T% of the 43 patients studied. Certain chemicals structurally similar to vinyl chloride ml ght be of etlologlc Importance among patients who have no documented exposure to any of the established causes of ASL. Descriptors: HUMAN THORIUM 01 OXIDE ARSENIC VINYL CHLORIDE Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM STUO-GENERAL( 10060): MINERALS< 10069); DIGESTIVE SYST-PATHOLOGY(* 14006); TOXI COL -PHARMACOLOGICAL(*22 504 ); TOXI COL-ENVIRONMN- TL.INOUSTR(*22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007): ENVIRON HEALTH-MISCELL STUDS(*37019): EP1 DEMlOL-ORGANIC 01S.NEOPLASMS(*37054) Biosys tema tlc Codes: HOMINIDAE(86215) R&S 138385 DIALOG Flle5: BIOS1S Prev i ews. 77-83/Jan BA7502;RRM2402(See F 11 e55 ) (c. BIOSIS 1982) (Item 157 of 858) User 3614 25jan83 203 1 72069528 STUDIES ON THE IMMOBILIZATION OF PAPAIN ON POLY VINYL CHLORIDE POWDER CHENG P-S: SHAW d-F DEP. CHEMISTRY, NATIONAL KAOHSIUNG TEACHER'S COLLEGE. NATL SCI COUNC MON 9 (2). 1981. 135-145. Coden: KHFKO Language : CHINESE Purified papain was covalently coupled with Insoluble carrier, PVC (polyvinyl chloride] power, by several different methods. The amount of activating reagents, the procedure for the act fvat Ion of PVC, and the t line for cowpl Ing react Ion affected the amount of enzyme Immoblllzed and Its relative activity. The maximal amount of papa In 1mmoblllzed was 47.8 mg/g of PVC and the maximal relative activity was 27.8%, Urea, the denaturatlng reagent of soluble papain, appeared to have little effect on the activity of Immobilized papain. The Km values for the Immob!1Ized enzymes were higher than those of native papain. The Immob11 1 zed papa In showed no significant loss In enzyme activity after 3 mo. storage at 4.degree. C. In the presence of 0.05 M L-cystelne and 0.02 M EDTA, the caselnolytlc activity was Increased by 20%. If the reuse.cycle was 12 h. the batch type operational half-life (casein as substrate) at 45.degree. C and pH 7.0 was 7.8 cycles; the half-life at 35.degree. C and pH 7.0 was extended to 27.0 cycles. If the reuse cycle was 1/2 h. the half-life at 66.degree. C and pH 7.0 was 20.5 cycles. Descriptors: MICHAEL IS CONSTANT CASEIN Concept Codes: BIOCHEM METH-PROTNS.PEPTOS.AM AC(10054); BIOCHEM STUD-GENERALC10060); BIOCHEM STUD-PROTE INS.PEPTIDES,A- MINO ACD(10064); BIOPHYS1MOLECUL PROP,MACROMOLEC(10506); BIOPHYS-BIOENGINEERING(10511); EXTERN EFF-TEMPERATURE(10614); ENZYMES-METHODS{10804); ENZYMES-CHEM,PHYSICAL STUDIES(* 10806) ; PLANT PHYSIOL-ENZYMES(*51518); PLANT PHYSIOL-APPARATUS,METH- 005(51524) . B losysternat1c Codes: CAR ICACEAE(25755) dusted on the Inside walls Improved the efficiency of po1ypropy1ene funnels. The catches In traps consisting of several plastic funnels or tubes under a roof and with Insecticide to prevent escape did not differ significantly from those In the sticky traps. A modified version of a new trap with a renewable sticky floor is described; this and the funnel traps are at present the most useful and practical for ca tch1ng P. cltrl male. Descriptors: Z-7 TETRADECENAL INSECTICIDE POLY ETHYLENE POLY VINYL CHLORIDE FUNNEL ISRAEL Concept Codes: GENERAL FIELD METHODS(01008); GENERAL FIELD APPARATUS(01010); GENETICS/CYTOGENET-SEX DIFFERENC(035 10 ) : BEHAVIOR BIQL-ANIMAL SEHAVI OR(*07003); BEHAVIOR BIOL-ANIMAL COMMUNICATN(*07006); BIOCHEM STUD-GENERAL(10060): ENDOCRINE SYST-GENERAL STUDIES(* 17002); TOXICOL-GENL/EXP STUDS.METHS(22- 501): PEST CONTRL GENL/PESTICS/HERBICS(54600); ECONOM ENTOMOL-FRUITS AND NUTS(*60006}; ECONOM ENTOMOL-BIDLDGICAL CONTRL( *60014); ECONOM ENTOMOL-CHEM PHYS CONTRL(60016 ) ; INVERTB PHYSIOL-I NSECTA - PHYSIOL( *64076) B losystemat1c Codes: LEPIDOPTERA(75330); ABSTRACTS OF ENTOMOLOGY(96000) 72065656 1 FURTHER FIELD TRIALS OF PHEROMONE DISPENSERS AND TRAPS FOR MALES OF PRAYS-CITRI LEPIDOPTERA YPONOMEUTIDAE STERNLICUT M; GOLDENSERG S; NESBITT B F; HALL D R DIV. OF ENTGMOL.. THE VOLCANI CENT., BET DAGAN. ISRAEL. BULL ENTOMOL RES 71 (2). 1981. 267-274. Codon: BEREA Language: ENGL ISH Dispensers made of different materials and loaded with the fema1e sex pheromone, (Z) - 7-te tradecena1, were field-tested for attractancy for males of P. cltrl (Mill.) In Israel. Hollow fibers of tow density polyethylene, low density polyethylene chips and natural ruhber septa wore bettor than hollow fibers of po1ypropy1ene, hollow fibers of a polypropylene-polyethylene mixture, , solid fibers of low dens tty polyethylene and PVC [po1yv1ny1ch1 or 1 do] tubes. In other tests, funneIs with wall angles of 60.degree. were Inferior to those with angles between 70 and 80.degree.; polyester funnels were superior to polystyrene and polypropylene ones, which were better than those of PVC or DIALOG Ftle5: 8I0SIS Previews 77-83/Jan 8A7502;RRM24C R&S 72053340 PRECURSOR STAGE OF HEPATO CELLULAR NEOPLASM FOLLOWING LONG EXPOSURE TO ORALLY ADMINISTERED CONTRACEPTIVES THUNG S N: GERBER M A OEP. PATHOL.. MT. SINAI SCH. MED., ONE GUSTAVE L. LEVY PLACE. NEW YORK, N.Y. 10029. HUM PATHOL 12 (5). 198 1. 472-475. Language: ENGLISH Coden: HPCQA Hepatic neoplasms and pel(osIs are known to occur In women taking contraceptIves orally. Hyperplasia of hepa tocy tes comb(ned with hypertrophy of sinusoidal lining cet1s and sinusoidal dilatation with progression to pellosls was observed In the liver of a patient who had been taking such contraceptIves for 10 yr. These changes resemb1ed the precursor s tage In the development of hepa t1c anglosarcoma Induced by vinyl chloride, Thorotrast and arsenic. In users of orally administered contraceptives these findings may precede the development of hepatoce1lular neoplasms. Descriptors: HUMAN VINYL CHLORIDE THOROTRAST ARSENIC CARCINOGEN HYPERPLASIA PELIOSIS ANG10 SARCOMA Concept Codes: BIOCHEM STUD-GENERAL(10060): MINERALS!10069); PATHOLOGY-COMPARATIVE( 1 2 503); OIGESTIVE SYST-PATHOLOGY( 14006) ; CARO IOVASC SYST-BLD VESS PATHOLt * 14 508); REPRODUCT SYST-PHYSIOL.BI0CHEM(16504); ENDOCRINE SYST-GONADS.PLACENTA( 1- 7006): DENTAL/ORAL BIOL-GENL STUD,METHS( 19001); PHARMACOL-CLI - NICAL PHARMACOL(22005); PHARMACOL -ENDOCR1NE SYST(220 16 ) ; PHARMACOL-REPRODUCT SYST.IMPLANT{*2202 8 ) : ROUTES OF IMMUNIZ,INFECT,THERAP(22100): TOXICOL-GENL/EXP STUDS.METHS(*2- 2501)TOXICOL-PHARMACOLOGICAL!*22504); NEOPLSMS/NEOPL AGNTS-CARCINOGENS!*24007) B1osysternat1c Codes: HOMINIDAE(86215); B I OS IS INTERNAL USE(97100) 72049295 VINYL CHLORIDE TOXICITY AFTER INHALATION CHYBA A 00-791 WARSZAWA, UL. CHOCIMSKA 24. ROCZ PANSTW ZAKL HIG 31 (6). 1980 (RECD. 1981). 615-621. Coden: RPZHA Language: POLISH White rats were exposed continuously to vinyl chloride (Inhaled air) In concentrations of 1, 1.8, 2, 3.6, 11.5 and 30. mg/m3 air. The animals were intoxicated In spec 1 a 1 chambers for 7-8 mo. During that time the rats were we 1ghed and hematological parameters and blood cholinesterase activity were determined. Ca level and alkaline phosphatase activity were determined In plasma. CNS ef f tc1ency was also tested. After complotion of exposure. weight of the internal organs was deteralned and histological examInat1ons were performed. Vinyl chi or Ide ln al1 concentrat Ions reduced the ef f t cienCy of CNS and prolonged blood clotting time. In plasma, concentrations of 3.6, 11.5 and 30 rag/m3 reduced Ca level. Descriptors: RAT NEURO TOXICITY BLOOD CHOLIN ESTERASE ALKALINE PHOSPHATASE CALCIUM KINETICS Concept Codes : MICROSCOPY-CY 1 Ol.OG . CYTOCIIRM TECH(0 1054 ) ; MICROSCOPY-HISTOL.HISTOCHEM TECH(01056): CYTOl OGY/CYTOCHFM-AN- lualS 1982) (Item 159 of 858) User 3514 25jan83 2032 IMAL(0250G); COMPARATIVE BIOCHEM-GENL STUDICS(1OO1O): BIOCHEM MEIH-PROTNS,PEPTDS,AM AC(10054); BIOCHEM METN-MINERALS(10059); BIOCHEM STUO-GENERAL!10060); BIOCHEM STUO-PROTEI NS,PEPTIDES,A - MINO ACD(10064); MINERALS(10069); ENZYMES-GEN,COMPAR STUD.COENZYMSt 10802); ENZYMES-PHYSIOLOGICAL STUOIES( 10808 ) : ANATOMY/HISTOL-MICRO,ULTRAMICRSC{ 11108); PATHOLOGY-COMPARATIVE( 12503); MET ABOLISM-GENL STUD.ME TAB PATltW( * 13002 ) ; M! NE R AL S ! * 130 10) : ME T ABOL I SM - PROT NS , PE PT DS . AM ACOS(*130 12); 8L00D/80DY FLDS-BLOOD CELL STUDS( 15004 ) ; BLOOD/SODY FLOS-8LD,LYM.RES PAT H(15006) ; RESPIRATORY SYST-GENL STUO.METHS(16001); NERVOUS SYST-GENL STUDS.METHS(20- 501); NERVOUS SYST-PAT HOLOGY(*20506); ROUTES OF IMMUNI 7.. INF ECT , THERAPf 22 100) ; TOXICOL-GENL/EXP STUOS.METHS( * 2 - 2501) Blosystematic Codes: MURIDAE(86375) 72049242 REPRODUCTIVE FUNCTION IN MEN EXPOSED TO CHEMICALS SANOTSKII I V; DAVTYAN R M; GLUSHCHENKO V I INST. 3 ND. HYG. OCCUP. DIS., ACAD. MED. SCI. USSR. MOSCOW. USSR. GIG TR PROF ZABOL Language: RUSSIAN 0 (5). 1980. 28-32. Coden: GTPZA Reproduc t t ve functIon was studied In men occupa tiona1 1y exposed to chloroprene, vinyl chloride or antlmonlte ore dust. This function was assessed on indirect evidence and from analyses of ejaculates. The rate of spontaneous abortions was significantly Increased among wives of men exposed to chloroprene as was the rate of stillbirths among wives of those exposed to vinyl chloride. Pathologic changes were detected in eJacu1 ates. Descriptors: CHLOROPRENE VINYL CHLORIDE ANTIMONITE ORE ABORTION STILL BIRTH OCCUPATIONAL HEALTH Concept Codes: CYTOLOGY/CYTOCHEM-HUMANS 02508); BIOCHEM STUD-GENERAL( 10060); MINERALS! 10069); PATHOLOGY-COMPARATIVE( 1 - 2503); MET ABOLISM-GENL STUO,METAB PATHW( 1 3002) ; MINERALS( 1 30 1- 0): BLOOD/BODY FLDS-OTHER BODY FLDS< 15010); REPROOUCT SYST-GENL STUOS.METHSt 16501); REPRODUCT SYST-PATHOLOGY(* 16506) ; TOXICOL-ENVIRONMNTL.INDUSTR(22506); DEVELOPMNTL B10L-PATH0- LOGI CAL( *25503) ; ENVIRON HEALTH-OCCUPATNL HEALTH( *370 13) ; ENVIRON HEALTH-AIR. WATR.SL POLl.Nt *370 1 5 ) Blosystemat tc Codes: HOMINIDAE(862 15); BIOS IS INTERNAL USE(97000); BIOSIS INTERNAL USE(97100) OIALO BIOSIS Previews 77-83/dan 8A75C R&S 13838 720-192 A 1 TIME COURSE OF THE HEART RATE AND GALVANIC SKIN REFLEX DURING NIGHT SLEEP IN PATIENTS WITH CHRONIC OCCUPATIONAL INTOXICATION WITH VINYL CHLORIDE GNESINA E A: PSHENITSYNA A I INST. IND. HYG. OCCUP. DIS., GORKI, USSR. GIG TR PROF ZABOL Language: RUSSIAN 0 (5). 1980. 39-42. Coden: GTPZA Heart rate and galvanic skin reflex were studied In polygraphic records of night sleep In 20 patients with chronic occupational Intoxication by vinyl chloride, a compound with narcotic action. A correlation was established between the Impoverishment of the dream pattern and changes In heart rate and galvanic skin reflex distribution patterns. Characteristic differences between these patterns at different stages of Intoxication were described. Descriptors: HUMAN KINETICS OCCUPATIONAL HEALTH Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(02508): BEHAVIOR BIOL-HUMAN BEHAVIOR(07004); BIOCHEM STUO-GENERAL(10060); PATHOLOGY-COMPARATIVE{ 12503): METABOLISM-GENL STUD,METAB PATHWt13002): CAROIOVA SC SYST-GENL STUDS.METHS{ 1 450 1 ) ; CAROIOVASC SYST-HEART PATHOLOGY(*i4506); INTEGUMENT SYST-GENL STUDS,METHS( 1850 !) : INTEGUMENT SYST-PATHOLOGY(*18506); NERVOUS SYST-GENL STUOS.METHS(2050)): NERVOUS SYST-PATHOLDGY( 20506 ) ; PSYCHIATRY-PSYCHPATH-DYNM,THERAP(*21002): TOXICOL -ENVIRQNMNTL,INDUSTR(*22506); ENVIRON HEALTH-DCCUPATNL HEALTH{*37013); ENVIRON HEALTH-A1R,WATR,St POLLN(* 37015) B1osystematIc Codes; H0MINI0AE{86215) 72046537 EVIOENCE FOR ENDOTHELIAL CELL ORIGIN OF VINYL CHLORIDE INOUCED HEPATIC ANGIO SARCOMA FORTWENGLER H P dR; JONES D; ESPINOSA E; TAMBURRO C H D1V. DIGESTIVE DIS. NUTRITION, DEP. MED., HEALTH SCI. CANCER CENT., UNIV. LOUISVILLE; KY. 40292. GASTROENTEROLOGY 80 (6). 1981. Language: ENGLISH 1415-1419. ' Coden: GASTA Prev1ous reports of [human] hepat1c ang1 osarcoma have not clearly defined the cellular type from which this tumor arises, as evidenced by the terminology of endothelioma, Kupffer cell sarcoma, endothelial cell sarcoma and hemang1oendo tho 1 1 a 1 3arcoma. o tc.. which were used tnterchangeably. There was no consensus on the separate entity of Kupffer and sinusoidal endothelial cells. Evidence for the endothelial coll origin of this tumor Is provided by demonstrating factor VIII, a known endothelial cell marker. In tho tumor cells. F1uorosconco duo to the presence of factor VI11 nppem nd Intense In tho tumor sinusoidal cells of nit 4 vinyl chloride-associated angiosarcomas s Hid led, whereas normal liver sinusoidal lining colls shownd negligible f1uoresconco. (loser Inters: HUMAN KUPFFER CELL' CARCINOGEN FACI0R-VI1I FLUORESCENCE Concept Codes: CYT0L0GY/CYT0CI1F.M-HUMAN( *02508) ; BIOCHEM STUD-GFNERA1. ( 10060); BIOCHEM STUD-PROTEINS.PEPIIDES,AMINO ACO ( 10064 ) ; PATHOI.OGY -COMPARAT I VE ( 12 503 ) : PAT HOI OGY - D I AGNOST I - (c. BIOSIS 1982) (Item 162 of 858) User 3614 25jan83 2033 C( 12504); DIGESTIVE SYST-GENL STUDS,METHS( 14001) : DIGESTIVE SYST-PATHOLOGY* 14006); CARDIOVASC SYST-BLD VESS PATHOL(1450- 8): BLOOD/BODY FLOS-BLOOD,LYMPH STUOt15002); BLOOD/BOOY FLDS-BLD,LYM,RES PATH(15006); BLOOD/BOOY FLOS-LYMPHAT TISS,RES(15008); TOXICOL-GENL/EXP STUOS.METHS(*22501): NEOPLSMS/NEOPL AGNTS-OIAGNS METH{* 24001 ); NEOPLSMS/NEOPL AGNTS-BIOCHEM(*24006); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS( *2400- 7); NEOPLSMS/NEOPL AGNTS-BLOOD.RES(* 24010): ENVIRON HEALTH-OCCUPATNL HEALTH(37013) Btosystemat1c Codes: HOMINI DAE(86215) 72041601 COMPLICATIONS OF CARBON DI OXIDE LASER SURGERY OF THE LARYNX MEYERS A DEP. OTOLARYNGOL.. UNIV. COLO. HEALTH SCI. CENT., DENVER, COLO . ANN OTOL RHINOL LARYNGOL Coden: AORHA , 90 (2 PART 1). 1981. 132-134. Language: ENGL ISH Since the Introduction of C02 laser surgery, surgeons have stressed tho Importance of protecting nontarget structures f rom errant irradiation. A)though striking areas outside the intended field may Inflict little or no damage, Irradiating an exposed endotracheal tube may result In an endotracheal fire. Recent experience with a case of endotracheal tube Ignition Involving a 28 yr old man led to a reevaluation of those factors associated with this serious complication. To determine the best endotracheal tube to use during laser surgery of the larynx, the flammability of polyvinyl chloride and red rubber endotracheal tubes was compared. Several factors were noted to contribute to the potential hazard of endotracheal tube Ignition. Since rod rubber tubes are less flammable, they should be used during laryngeal C02 laser surgery. Descriptors: HUMAN TRACHEA FIRE POLY VINYL CHLORIDE RED RUBBER HAZARD Concept Codes; RADIATION BIOL-RADTN,ISOTOP TECH*06504 ) ; RADIATION BIOL-RADT N EFF.PROTECT( *06506); B1OPHYS-GENERAL B10PHYS TECH( 10504); ANATOMY/HISTOL-SURGERY(* 11105); PATHOLOG- Y-THE RAPy( 125 12); RESPIRATORY SYST-GENL STUD,METHS( 1600 1 ) ; RESPIRATORY SYST- PATHOLOGY(16006) Blosystemat1c Codes: HOMINIDAE(862 15) DIALOG F11e5: BIOSIS Previews 77-fl3/Jan 8 R&S 138388 ) (c. BIOSIS 1902) (Item 165 of 858) User 3614 25jan83 2034 72040719 THE EFFECTS OF NALOXONE ON THE ANALGESIC ACTIVITIES OF GENERAL ANESTHETICS SMITH E H; REES d M H DEP. PHARMACOL.. MATERIA MED. THER., MED. SCH.. MANCH. , MANCHESTER M13 9PT, ENGL.. UK. UNIV. EXPERIENTIA (BASEL) Language: ENGLISH 37 (3). 1981. 289-290. Coden: EXPEA Inhaled concentrations of N20 (80%), halothane (O.S%). trichloroethylene (0.5'/.) and s.c. ethanol (1 ml/kg) caused similar degrees of excitation and ataxia in mice. N20. trichloroethylene and ethanol caused analgesia (hot plate and writhing tests), but only that caused by N20 was antagonized by naloxone (20 mg/kg) . Halothane lacked analgesic activity. [N20 was the only anesthetic that released endorphins. The underlying reasons were unclear.) Descriptors: MOUSE CENTRAL STIMULANT NITROUS OXIDE HALOTHANE TRI C1ILOROETHVLENE ETHANOL CENTRAL DEPRESSANT ANTAGONIST ENDORPHIN RELEASE HOT PLATE WRITHING TEST Concept Codes: BEHAVI t)R BIOL-ANIMAL BEHAVIOR (07003) : 8 I OCHEM-GASES(10012): BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACDU0064); EXTERN EFF-1IOT( 10618) ; MOVEMENT ( 12 100) : MET AE3DL I SM-PROTNS . PEPTDS . AM ACOS ( 1 30 1 2 ) ; RESPIRATORY SYST-GENL STUO.METHS( 1 GO01); ENDOCRINE SYST-NEUROENDOCRINOLOG(17020); MUSCLE SYST-PATHOLOGY( 17506); NERVOUS SYST-PHYSIOL.B!OCHEM(*20504): PSYCHIATRY-PSYCHOPHYS10- LOGY(21003); PHARMACOL-DRUG METAB,METAB ST IMU(* 2 2003); PHARMACOL-NEUROPHARMACOLOGY(*22024); PHARMACOL-PSYCHOPHARMACOLOGY(*22026); ROUTES OF IMMUNIZ.INFEC- T.THERAP(22 tOO); TOXICOL-GENL/EXP STUDS.METHS(2 2501 ): TEMPERA TURE -GENL,METHS(23001) Biosystematic Codes: MURIDAE(86375) control. T he da t a Ind(co to t ha t the me tobol 1c convorsion of OP is different in tho DrosophilB as compared to the rat liver microsomal fraction. In accordance with mutagenic data on Drosophila in vivo, vinyl chloride was a fairly weak mutagen In this Drosophiia/Sa1mone11a in vitro system. The relevance of these results for the understanding of Drosophila metabolism and the value of the Salmonella test as a rapid and sensitive Indicator of the formation of reactive metabol I tes 1n Drosophlla are discussed. Descriptors: RAT LIVER LARVA AROCLOR 1254 BETA NAPHTHO FLAVONE METABOLIC-DRUG INDICATOR Concept Codes: GENET ICS/CYTOGENET-GENL STUOIES( `03 502 ) : COMPARATIVE BIOCHEM-GENL STUDIES(l0010); BIOCHEM STUO-GENERAL- (10060): BIOCHEM STUD-NUCL ACD,PURNS.PYRM(10062); REPLICATN.T- RANSCRIPTN.TRANSLATNC10300); METABOLISM-GENL STUD.METAB PATHW( 13002); METABOLISM-NUCL ACO.PUR INS,PYRIM( 13014); DIGESTIVE SYST-GENL STUDS.METHS(14001): DIGESTIVE SYST-PAT1I0L- OGY( 14 006); PHARMACOL-DRUG METAB.METAB STIMU( '2 2003 ) ; TOXICDL-GENL/EXP STUOS.METMS(* 22501); NEOPLSMS/NEOPL AGNTS-CA- RCINOGENS(*24007 ); DEVELOP MN T L BIOL-GEN MORPHGENSIS(25508 i ; BACTERIAL AND VIRAL GENET ICSI 31500): MICROBIOLOG APPARAT.METHS,MEDIA(32000); IN VITRO STUDS-CELLULR.SUBCELL(32- 600); INVERTB PHYSIOL-INSECTA-PATHOL(* 64078) B losyStemat Ic Oodes: ENTEROBACTERI ACEAE{04810 } ; DIPTERA(753- 14); MUR1DAE(8G375) 7203932 1 METABOLISM OF DRUGS AND CARCINOGENS IN ISOLATED SUB CELLULAR FRACTIONS OF DROSOPHILA-MELANOGASTER 1. ACTIVATION OF VINYL CHLORIDE 2 AMINO ANTHRACENE AND BEN20 A PYRENE AS MEASURED BY MUTAGENIC EFFECTS IN SALMONELLA-TYPHIMURIUM HALLSTROM I; SUNDVALL A; RANNUG U; GRAFSTROM R; RAMEL C ENVIRONMENTAL TOXICOL. UNIT. WALLENBERG LAB.. UNIV. STOCKHOLM, S- 106 9 1 STOCKHOLM. CHEM-BIOL INTERACT 34 (2). 1981. 129-144. Coden: CBINA Language: ENGLISH The capacity of microsomal fractions from different Drosoph11a strains to activate 3 premutagens, 2-aminoanthracene (2-AA), vinyl chloride (VCM) and benzo[aJpyrene (BP) was investigated, using Salmonella typhimurtum as the indicator organism. A significant increase in the mutation response in the So 1 mono 1 In test system was obtained with all 3 substances in tho presence of a metabolizing system (S9) ' from Drosophila larvae. 2-AA was converted to highly mutagenic metabolIte(s) by tho Drosophila S9 and the mutagenic effect was further increased after pretreatment with Aroclor 1254 (PCB ) or .beta.-naphthof1avone (BNF). BP had only marginal mutagenic effects. causing less DIALOG F 11e5 : BIOSIS Prev 1 ews. 77-83/d. R&S 138389 Ie55 (c. BIOSIS 1982) (Item 187 of 858) User 3614 25jan83 2035 72037 37 4 TRAPS FOR MONITORING POPULATIONS OF THE CITRUS THRIPS SCIRTOTHRIPS-CITRI THYSANOPTERA THRIPIDAE TANIGOSHI L K; MORENO D S BOYDEN ENTOMOLOGICAL LAB., USDA. AGRICULTURAL RES., RIVERSIDE, CALIF 92521. SEA. CAN ENTOMOL 113 (1). 19B1. 9-12. Language: ENGLISH Coden: CAENA Modified versions of the standard Reed-Rich citrus thrlps trap were compared for trapping efflclency and 1abor requ1 red. The number of migrant S. citrl (Moulton) captured per unit trapping area of a PVC[pol yv1ny1 chi or 1 do]-acctate trap was comparable to the number captured per unit area of the Reed-Rich trap, although the PVC-acetate trapping surface was .apprx. 35% that of the 929 cm2 standard trap. The reduced counting surface and the use of disposable acetate sheets reduced to 1/4 the time required for f1 eld-1aboratory handling. preparing and processing. The PVC-acetate trap Is recommended as a new standard trap for monI tor Ing S. citri population levels citrlcu1ture. In California and Arizona [USA] Descriptors: REED-RICH CITRUS THRIP TRAP POLY VINYL CHLORIDE ACETATE TRAP CALIFORNIA ARIZONA USA Concept Codes: GENERAL FIELD METtlODSfO1008): GENERAL FIELO APPARATUS(01010); BIOCHEM STUO-GENERAL( 10060); HORTI CULT-TROP FRUIT,NUT,PLANTAT(+53004); PEST CONTRL GENL/PEST[CS/HERBICS(- 54600); ECONOM ENTOMOL-FRUITS AND NUTS( 60006); ECONOM ENTOMOL-CHEM PHYS CONTRL(*60016) 8losystema t tc Codes: RUTACEAE(26685); THYSANOPTERA(75350) 72035790 FORMATION OF VINYL HALIDES FROM VINYL CATIONS GENERATED BY ACETYLENIC PARTICIPATION IN BIOMIMETIC POLYENE CYCLIZATIONS JOHNSON W S; WARD C E; BOOTS S G; GRAVESTOCK M B; MARKEZICH R L; MCCARRY B E; OKORIE D A; PARRY R d DEP. OF CHEM., STANFORD UNIV.. STANFORD, CALIF. 94305. , U AM CHEM SOC 103 (1). 1981. 88-98. Coden: JACSA Language: ENGLISH The object of this study was to examine the fate of vinyl cations (resulting from blomlmetlc polyene cycl1zat1ons) In the presence of various halides as sources of nuc)eophlies. Treatment of the dlonynol 1 with trtf1uoroacet1c acid In methylene chloride for 45 min at -78.degree. C resulted In the Isolation of the rearranged blcycllc vinyl chloride 6 In 56% yield. Confirmation of the structure and isomeric purity of 6 was obtained by exhaustive ozonlzation to give dfketo ester- 9 followed hy Wo 1ff-K1schnor reduction and then estor 1fteat1 on to yield the ester, the structure of which was conf1rmod by 110 exchange of the protons .alpha. to the carbornethoxy group. The configuration of the ring fusion In 6 was trans In the following manner. Selective ozon1zat1 on gave the chioro ketone, which was converted Into the chtoro olefin by Wo 1ff-K1schner reduction. Further ozonlzation afforded the knto ester, which was converted Into the diacid by sodium hypobromlte oxidation. Esterification afforded the diester. Wolff-K1schner reduction of the known keto diester. More careful examination of the products from the aforementioned cyclizatlon showed the presence of 8% ketone (after hydrolytic workup). Identical cyclizatlon conditions of 1, except at 0.degree. C. gave 55% vinyl chloride 6 and 45% ketone while use of a 7.5:1 pentane:1,2-d1chloroethane mixture at O.degree. C ted to 11% vinyl chloride 6 and 89% ketone 8. CyclIzatIon of dienynol 1 with stannic chloride In I.1-dlchloroethylene at -35.degree. C for 45 min gave a 53% yield of 3 Isomeric vinyl ch1 or Ides, In a ratio of 8:75:12. The successfu I eye 1 Ization of dienynol 1 led to more extensive cyclizatlon studies of substrates which provided tetracyclic products. The most thoroughly studied case was that of trlenynol 3. which on treatment with stannic Chloride in 1,1-dI chioroethy1ene at approximately -30.degree. C for 50 min, gave a 64% yield of 3 tetracyclic products A. B and C in a ratio of 15:73:12 by VPC. Product A was the chloro diene by hydrogenation of the DELTA, l-olefInlc bond foil owed by ozon1z a t1 on to give 5.beta. . 13.a 1pha.-androstan-17-one. which was compared with an authentic sample prepared by irradiation of 5.beta.-androstan-17-one. Products B and C were chloro dienes by conversion of the mixture Into 5.beta.-androstan-17-one and the keto ester. A sys teraatic variation of reaction conditions as well as the use of mlxed-hallde sources led to evidence for a possible mechanism for the formation of all 3 products from an In termed 1 ary t r I eye 11c cation. Descriptors: 5-BETA ANDROSTAN-17-ONE 5-BETA 13-ALPHA ANDROSTAN-17-ONE Concept Codes: BIOCHEM METH-GENERAL(*10050); BIOCHEM METH-STEROLS.STER0IDS{* 10057); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-LIPIDS(10066); BIOCHEM STUD-STEROLS.STEROI 0S(* 10- 067); 8I0PHYS-M0LECUL PROP,MACROMOLEC(*10506); REPRODUCT SYST-PHYSIOL,BIOCHEMt16504); ENDOCRINE SYST-GONADS,PLACENTA(t- 7006); PHARMACOL-GENERAL STUDIES(22002): PHARMACOL-PSYCHOPHAR- MACOLOGY(22026) R&S 138390 Previews 77-B3/dan BA7502 ; RRM2402 ( See Flle55) {c. BI0S1S 1982) (Item 169 of 858) User 3614 25Jan83 203G 72035100 EFFECTS IN THE RAT OF INHALING POLY VINYL CHLORIDE DUST AT THE NUISANCE DUST LEVEL RICHARDS R U; ROSE F A; TETLEY T D; COBB L E; HARDY C J DEP. BIOCHEMISTRY, UNIV. COLL. CARO IFF, P.O. BOX 78. CARDITF CF1 1 XL, U.K. ARCH ENVIRON HEALTH 36 (1). 1981. 14-19. Coden: AEHLA Language: ENGL ISH Rats Inhaled a paste polymer polyvinyl chloride [PVC] dust at an aerosol concentration of 10 mg/m3 for 6 h/day, 5 days/wk for 15 wk. A small number of randomly scattered 1ung Ies1ons were detected at 15 wk; these lesions were also present 15 wk after exposure to PVC had ceased. Few If any biochemical changes were detected at the a 1veolar,surface in lung tissues or other organs of PVC-exposed rats. At nuisance dust level this form of PVC polymer exhibited weak biological reactivity. Descriptors: LUNG KINETICS NEGLIGIBLE TOXICITY AIR POLLUTION Concept Codes: CYTOLOGY/CY T0CI1EM-ANI MALI 02506); B10CHEM-GAS- ES(10012): BIOCHEM STUD-GENERAL(10060): PAIHOLOGY-GENERAL STUDIES(12502): PATHOLOGY-COMPARATIVEC12503); PATHOLOGY-01AGN OSTIC ( 12504); METABOLISM-GENL STUD.METAB PATHW(13002); RESPIRATORY SYST-GENL STUD,METHS{16001); RESPIRATORY SYST-PATHOLOGY(* 16006); ROUTES OF IMMUNI 2. INFCT,THERAPf22 100) ; TOXICOL-GENL/EXP STUDS,METHS(*22501); TOXICOL-ENVIRONMNTL.I- NDUSTRf*22506); ENVI RON HEALTH-A I R , WATR , SL POLLN( *370 15 ) B(osystematic Codes; MURIDAE{86375) 72035000 ADSORPTION AND DESORPTION OF PERMETHRIN AND OTHER PESTICIDES ON GLASS AND PLASTIC MATERIALS USED IN BIOASSAY PROCEDURES SHAROM M S; SOLOMON K R DEP. ENVIRONMENTAL BIOL., UNIV. GUELPH, GUELPH. ONT,, NIG 2W1 . CAN J FISH AOUAT SCI 38 (2). 1981. 199-204. Coden: CJFSD Language: ENGLISH Labora tory studies were conducted to determine the adsorption and desorption of permethrin on glass and several plastic materials that may be used for the construction of limnocorrals. The Insecticide was substantially adsorbed on polyethylene, polyvinylchloride. glass and Teflon. Adsorbed permethrin was not easily desorbed from polyethylene and polyvinylchloride by several water rinses. Increased adsorption of the Insecticide was observed with Increasing temperatures. A study on the adsorptIon of several herbicides [barban, trifluralln, metrlbuzln. atraztne. picloram and amltrole] . of various water solubilities Indicated that trifluralln was adsorbed to glass and that there was no general relatlonhlp between adsorption of the herbicide on polyvinylchloride and water solubility. Descriptors; BARBAN TRIFLURALIN AMITROLE METR1BUZIN ATRAZINE PICLORAM HERBICIDE INSECTICIDE POLY ETHYLENE POLY VINYL CHLORIDE TEFLON LIMNOCORRAL WATER SOLUBILITY Concept Codes: ECOLOGY-GENL STUD IE S,METHODS(07502); ECOLOGY-LlMNOLOGYt*07514); ECOLOGY-AOUATIC WILOtlFE MGM1(0751- Drrnm r t d r p v n r n* r r*~7 r: ** ' . METH-GENERAL{10050): BIOCHEM STUO-GENERAL(10060): EXTERN EFF-TEMPERATURE( 10614); TOX ICOL -ENVIRDNMNTL.INDUSTR( *22506 ) ; TEMPERATURE-GENL.METHS{23001); ENVIRON HEALTH-A IR.WAIR.SL POLLNt 37015); PLANT PHYSIOL-GROWTH SUBSTANCES(5 15 1 4 ) ; AGRONOMY-WE EDS AND WEED CONTROL(525 1 8 ) ; PEST CON f R L GENL/PESTICS/HERBICS(*54600); CONTRL(600 1 6 ) ECONOM ENTOMOL-CHEM PHYS Blosystemat1c Codes; ABSTRACTS OF ENTOMOLOGY(96000) 72032371 VINYL CHLORIDE INDUCED ANGIO SARCOMA AND HEPATO CELLULAR CARCINOMA OF THE LIVER KOISCHWITZ D; LELBACH W K; LACKNER K; HERMANUTZ D RADIOL. KLIN., UNIV. BONN, R0ENTGENA8T. MED. KLIN.. 5300 BONN-VENUSBERG. W. GER. FOR T SCHR GEB ROENTGENSTR 283-290. Coden: TGRNA Language: GERMAN NUKLEARMED 134 (3). 198 1. Three patients with -Industrial exposure to PVC [polyvinylchloride] are described, who developed angiosarcomas of the liver; In 1 patient this was combined with a mu 1tf- 1ocutnr primary hepatocellular carcinoma. The epidemiology, clinical features and diagnosis are discussed, with particular reference to angiography. sonography and computerized tomography [CT). The non-Invasive methods, such as CT and sonography, are the technfques of choice If an angiosarcoma Is suspected after long exposure to-PVC. Descriptors: HUMAN OCCUPATIONAL HAZARD RADIOGRAPHY DIAGNOSIS Concept Codes: GENL BIOL-INFRMTN,DOCU.COMP APPL(00530); PHOTOGRAPHY-METHS.MATLS,APPARAT(01012); MATHEMATIC BIOL/STATI STIC ME Til (04 500): RADIATION B10L-RADTN,I SOT OP TECH(06504); BIOCHEM STUD-GENHAL(10060); BIOPHYS-GENERAL BIOPHYS TECH( 10504); ANATOMY/HISTOL-RADlOLOGIC( 11106); PATHOLOGY-DI AG- NOSTiC( 12504 ); DIGESTIVE SYST-PATHOLDGY[* 14006 ) ; CARD10VASC SYST-GENL STUDS,METHS(14501); CARDIOVASC SYST-BLD VESS PATHOLf* 14508); TOXI COL-ENVIRONMNTL, INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-OIAGNS METH(*24001); NEOPLSMS/NEOPL AGNTS-CARCIN OGENS (* 24 007 ) ; ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-AIR.WATR.SL POLLN(37015) Blosystemattc Codes: KOMINIDAE(862 15) DIAL0G^Ue5: BI. R&S 138391 BA7502 ; RRM2402 ( See F1!e55) (c. BIOSIS 1982) (Item 172 of 858) User 3614 25janB3 2037 72030340 RELEASE RATES AND ATTRACTION OF POLY VINYL CHLORIDE LURES CONTAINING SYNTHETIC SEX ATTRACTANT OF THE SPRUCE BUDWORM CHORISTONEURA-FUMIFERANA LEPIOOPTERA TORTRICIOAE SANDERS C d GREAT LAKES FOREST RES. CENT.. CANADIAN FORESTRY SERVICE. SAULT STE. MARIE. ONTARIO P6A 5M7. CAN ENTOMOL 113 (2). 1981. Language .'ENGLISH 103-112. Coden: CAENA Release rates of synthetic attractant of the spruce budworm, C. fumlferana (Clem.), from a PVC [polyvinyl chloride] formulation were determined by weight loss. They varied in direct proportion to the Initial concentration of the attractant and also with the size of the pellet. Release rates declined by .apprx. 50% over the time Intervals of 10-40 days and 40-100 days. Initially they were 2-3 times lower at 10.degree. C than at 21.degree. C, but were far more constant over time at the 1ower temperature. A pellet weighing 130 mg containing 42 .mu.g of attractant released an estimated O.1-1 .mu.g/day or 4-40 ng/h. which Is close to the rate of emission by a calling female (Silk, et al. 1980), and field trapping data showed that a lure this size attracted the same number of males as a calling female. Descriptors: TEMPERATURE Concept Codes: GENERAL FIELD METH0DS(01008); GENERAL FIELD APPARATUS(OIOIO); GENETICS/CYTOGENET-SEX 01FFERENC(03510): BEHAVIOR BIOL-GENL,COMPAR BEHAV(*07002); BEHAVIOR BI0L-ANIMAL BEHAVI0R(*07003); BIOCHEM STUD-GENERAL(10060): EXTERN EPF-TEMPERATURE(10614); ENDOCRINE SYST-GENERAL STUDIES(* 17002 ) ; PEST CONTRL GENL/PESTICS/HERBICS(54600): ECONOM ENTOMOL-TREE.ORN.WD PROOS(*60010); ECONOM ENTOMOL-81OLOGICAL CONTRL(60014); INVERTS PHYSIOL-INSECTA-PHYSIOL(*64076) 8losystematIc Codes: LEPIOOPTERA(75330) 72030337 RESISTANCE OF POLYMER FILMS TO PENETRATION BY LESSER GRAIN BORER RHYZOPERTHA-DOMINICA AND DESCRIPTION OF A DEVICE FOR MEASURING RESISTANCE HIGHLAND H A; WILSON R STORED-PRODUCT INSECTS RES. DEVELOPMENT LAB.. P.O. BOX 22909, SAVANNAH. GA. 31403. J ECON ENTOMOL 74 (1). 1981. 67-70. Coden: JEENA Language: ENGLISH In tests with a newly developed laboratory dovlco for determining the resistance to penotration of flexihle packaging films by adult R. domtnlca (F.), polyurethane and polyester f1)m3 wore the most resistant of Ifl types tested. Polypropylene and ftuorlnated C polymer films varied In resistance to ponotrntion. Plasticized polyvinyl chloride, lonomor, cellulose propionate. polyvinyl alcohol, saran and po1yo thylene-ethy1ene vinyl acetate copo1ymor films were susceptible to penetration, as were 7 types of cellophanes. Descriptors: CELLULOSE PROPIONATE POLY URETHANE POLY ESTER POLY PROPYLENE FLUORINATED CARBON IONOMER PLASTICIZED POLY VINYL CHLORIDE POLY VINYL ALCOHOL SARAN POLY ETHYLENE ETHYLENE VINYL ACETATE CELLOPHANE Concept Codes: FOOD TECU-PREP.PROCESSNG,STORAGE( 13532 ) ; PEST CONTRL GENL/PEST1CS/HERBICS(* 54600); ECONOM ENIOMOL - STOR- ED PRODUCTS(*60008) Blosystemat1c Codes: COLEOPTERA(75304) 72021785 FREEZING IN THE PRIMARY POLY VINYL CHLORIDE PLASTIC COLLECTION BAG A NEW SYSTEM FOR PREPARING AND FREEZING NONREJUVENATED AND REJUVENATED RED BLOOD CELLS VALERI C R; VALERI D A; ANASTASI J; VECCHIONE J J; DENNIS R C; EMERSON C P NAVAL BLOOD RES. LAB.. 615 ALBANY ST.. BOSTON. MASS. 02118. TRANSFUSION (PHILA) 21 (2). 1981. 138-149. Coden: TRANA. Language: ENGLISH Red blood cells [human] were stored at 4.degree. C In the prImary bag with an integrally attached empty transfer pack so that the red blood cells could be rejuvenated or not. as desired before glycero1 1zat1 on and freezing. The rejuvenation and glycerol solutions were added through ports in the system. After g1ycerol izat1 on the red blood cells were concentrated by centrifugation to remove the supernatant glycerol before freezing with 40% w/v glycerol In the primary polyvinylchloride (PVC) plastic container (n -80.degree, C. After thawing the red blood cells were washed using either the Haemoneltcs Blood Processor 115 or the IBM Blood Processor 2991-1 or 2991-2. In each system, 50 ml of 12% NaC1 and 1.5-1.6 l of 0.9% NaCl 0.2% glucose-25 meq/1 disodium phosphate were used. Recovery of red blood cells In vitro was 91%. After 3 days of postwash storage at 4.degree. C, nonrejuvenated red blood cells had a mean 24 h posttransfusion survival of 88%, Indated-rejuvenated red blood cells a value of 90%, and outdated-rejuvenated red blood cells a value of 81%. This new, system Is simpler and safer than methods previously used In this laboratory. and red blood cell recovery and 24 h pos ttransfusIon survivals were comparable or better. Descriptors: HUMAN Concept Codes: CYT OLOGY/C Y T OCHEM-KUMAN(02508); BIOCHEM STUO-CAR80HYDR.( 10068); MINERALS( 10069); BIOPHYS- GENERAL BIOPHYS TECIU 10504): EXTERN EFF-TEMPERATURE( IOG14); EXTERN EFF-C0LD(10616); MOVEMENT(12100); BLOOD/BODY FLDS-GCNL STUDS,METHSt* 15001) BLOOD/BODY FLDS-8L000 CELL STUDS(15004); TEMPERATURE-GENL,METHS(23001); TEMPERATURE-CRYOBIOLOGY(*230041 BlosystemotIc Codes: HOMINIDAE(86215) R&S 138392 0IAL0G Flle5: BlOSIb r, 7502;RRM2402(See F ! 1e55) (c. BIOSIS 1982) (Item 175 of B58) User 3614 25jan83 2038 72010 106 THE INDUCTION OF ERRORS DURING IN-VITRO DNA SYNTHESIS FOLLOWING CHLORO ACETALDEHYDE TREATMENT OF POLY DEOXY CYTIDYLIC DEOXY GUANY LIC-ACID THYMIDYLIC-ACID TEMPLATES AND POLY OEOXY ADENYLIC HALL J A; SAFFHILL R; GREEN T; HATHWAY D E' PATERSON LABORATORIES, CHRISTIE HOSPITAL AND HOLT RADIUM INSTITUTE. MANCHESTER M20 9BX. CARCINOGENESIS {LDND) CRNGD 2 (2). 1981. 14 1- 146. Coden: Language: ENGL ISH Chloroacetaldehyde, a rearranged metabolic product of the human carcinogen vinyl chloride. reacts with the ONA-Hke polymers poly(dA-dT) and poly(dC-dG) to form etheno-adducts of the adenine and cytosine bases. These treated polymers. when used as templates for Escherichia coll DNA polymerase I in an in vitro assay. show a decreased ability to direct DNA synthesis. At the same time. increased relative levels or non-comp 1ementary nucleotides are Incorporated. With the poly(dA-dT) templates 1 dGMP" residue is incorporated for every 60 ethenoadenina residues present while no Increased mIsIncorporation of dCMP was detected. With the poty(dC-dG) templates 1 m1s1ncorporat1 on of dAMP or dTMP occurred In the presence of .apprx. 30 and 80 ethenocytos1ne residues, respectIvely. A nearest neighbor analysis shows that with the modified poly(dC-dG) templates the majority of the errors were Incorporated opposite cytosine (or modified cytosine) bases. Descriptors: ESCHERICHIA-COLI HUMAN VINYL CHLORIDE CARCINOGEN Concept Codes: GENETICS/CYTOGENET-GENL STUDIES(03502); BIOCHEM STUO-GENERAL{10060); BIOCHEM STUD-NUCL ACO.PURNS.PYRM- (10062): BIOCHEM STUD-PROTEINS.PEPTIDES,AMI NO ACD( 10064); ENZYMES-PHYSIOLOGICAL STUDIES(* 10808): METABOLISM-GENL STUD,META8 PATHW(* 13002): METABOLISM-PROTNS.PEPTDS.AM AC0S(I3- 012): METABOLISM-NUCL ACD,PUR INS,PYRIM(* 13014); TOXI COL-GENL/- EXP STUDS.METHS(*2250 1 ); NEOPLSMS/NCOPL AGNTS-CARCINOGENS<*24 - 007); BACTERIA-PHYSIOLOGY,BIOCHEMISTRY(31000): IN VITRO STUDS-CELLULR.SUBCELL(32600) BlosystematIc Codes: ENTEROBACTERlACEAE(04810); KOMINIDAE(B- 6215) d 1 ver-operalnd. hand-held PVC [polyvinyl chloride) cores and screened through a 0.5 mm sieve. Eight species, Mysella planulata, Ampelisca abdlta. Streblosplo benedlctl. Grand 1dI ere 11 a bonnIeroIdes, Mullnla lateralis, Medlomastus calIfornlensls, Cyclaspls sp. and Nereis succlnea were numerically dominant. accounting for > gS/C of the total density during the en t .1 re period. These 8 spp. are nil classified as r-strateg Ists and utilize several dispersal mechanIsms to attain large populatlons rapidly. Circumstantial evidence Is presented which Indicates that A. abdlta. although classified as an r-strategist, may be an effective interference competitor. Descriptors: MYSELLA-PLANULATA AMPELI SCA - ABDITA STREBLOSPIO- -BENEDICTI GRANOIDIERELLA-BONNIEROIDES MUL1NI A-LATERALIS MEDIOMASTUS-CALIFORNIENSIS CYCLASPIS-SP NEREIS-SUCCINEA R STRATEGIST SUMMER INTERFERENCE COMPETITOR HYPOXIA SCUBA DISPERSAL POLY VINYL CHLORIDE CORE SCREEN STATISTICS Concept Codes: GENERAL FIELD METHODS(01008): GENERAL FIELD APPARATUS(OIOIO); MATHEMATIC BIOL/STATISTIC METI i (04500) ; ECOLOGY-BIOCLI MAT OL.BIOMETEOROL{07504 ); ECOLOGY- ANIMAL( *07 508) ; ECOLOGY-OCEANOGRAPHY,LIMNOLOGY( *075 10): ECOLOGY -WA T R RESRCH,FISHERY BIOL(07517); BIOCHEM-GASES(10012); EXTERN EFF-PRESSURE( 10606); MOVEMENT( 12 100) ; RESPIRATORY SYST-PATHOL- OGY( * 16006); INVERTB PHYSIOL-MOLLUSCA(64026) ; INVERTB PHYSIOL-ANNELI DA{64030); INVERTS PHYSIOL-CRUSTACEA(64054) B losystemat1c Codes: PELECYPOOA(61500); POLYCHAETA(65500); MALAC0STRACA{75112) 72015918 RESPONSE OF SOFT BOTTOM BENTHOS TO ANNUAL CATASTROPHIC DISTURBANCE IN A SOUTHERN FLORIDA USA ESTUARY SANTOS S L: SIMON J L FACULTY OF NATURAL SCI. AND MATHEMATICS. STOCKTON STATE COLL., POMONA, NJ 08240. USA. MAR ECOL PROG SF.R 3 (4). 1980 (RECD. 1981). 347-356. Coden: MESED Language: ENGLISH A portion of Hillsborough Bay (Tampa, Florida. USA) part of the Tampa Bay estuary, undergoes annual summor do faunatInn, prdrmmnbly duo tn hypoxia. Dissolves 02 levels are very low (< 1.0 mg/I) at the times of the dofaunat1ons. In the ensuing period between defaunatIons, recolonlzatIon occurs. Monthly samples for 42 consecutive months were wi loctoii hv sruo* DIALOG fUe5: BIOSIS Prev R&S 138393 JM2402(See F i 1e55) (c. BIOSIS 1982) (Item 177 of 858) User 3614 25Jan83 2039 72011114 INTER STRAND DNA CROSS LINKING BY 4 5' 8 TRI METHYL PSORALEN PLUS MONO CHROMATIC UV LIGHT STUDIES BY ALKALINE ELUTION IN MOUSE L-1210 LEUKEMIA CELLS COHEN L F; EWIG RAG; KOHN K W; GLAUBIGER D PEDIATRIC ONCOL. BRANCH. DIV. OF CANCER TREATMENT. NCI. NIH, BETHESOA, MD. 20205, USA. 0IOCHIM BIOPHYS ACTA Language : ENGL ISH 610 CD. 1980. 56-63. Codon; OBACA DNA cross) Inking by 4,5'.8-trImethy1 psora 1en and monochromatic UV light of wavelength 365 nin was studied In mouse L1210 leukemia cells. ONA breaks and crosslinking were evaluated by alkaline elution of ONA from poly{vinyl chloride) filters. Trlmethylpsoralen and 365 ran tight produced DNA crosslinks but not breaks. The kinetics of crosslinking .were linear with respect to concentration, and 2nd-order with respect to light exposure time. The latter finding supports the proposed 2-photon mechanism for the formation of dlodducts. In contrast to DNA crosslinking agents, l.e., nitrogen mustard, nitrosoureas and Pt, trimethy1 psoraten crosslinks were resistant to proteolytic digestion. Trlmethylpsoralen and 365 nm light produced Interstrand crosslinks, ns proposed for a blfunctlonal agent binding to bases on opposite DNA strands. Descriptors: RADJDSENSITI2ER METABOLIC-ORUG HEMATOLOGIC-DRUG ANTINEOPLASTIC-ORUG NITROGEN MUSTARD NITROSO UREAS PLATINUM PROTEOLYTIC DIGESTION PHARMACODYNAMICS Concept Codes; CYTOLOGY/CYTOCHEM-ANIMAL(02506); RADIATION BIOL-:RADTN. ISOTOP TECH(06504); RADIATION BIOL -RADTN EFF,PROTECT(*06506); BIOCHEM STUD-GENERAL!10060); BIOCHEM STUD-NUCL ACO.PURNS,PYRM(10062); BIOCHEM STUD-PROTEINS.PEPTID ES, AMINO ACD(10064); MINERALS!10069); BIOPHYS-MOLECUL PROP.MACROMOLECf* 10506); BIOPHYS-BIOENERGETICS( 10510); EXTERN EFF-LIGHT.DARKNESS!10604); METABOL1SM-GENL STUD,METAB PATHW(1- 3002); MINERALS! 13010); METABOLISM-PROTNS.PEPTDS.AM ACDS( 1301 - 2): METABOLISM-NUCL ACD,PUR I NS.PYRIM!13014); BLOOO/BODY FLDS-BLD.LYM.RES PATH!* 15006); BLOOO/BOOY FLDS-LYMPHA T TISS,RES(* 15008); PHARMACOL-DRUG MET AB.METAB ST IMU(*22003); PHARMACDL-BLOOD,HEMATO AGENTS(*22008); NEOPLSMS/NEOPL AGNTS-C- ELL LINE(*24005); NEOPLSMS/NEOPL AGNTS-THERAP,AGNT(*24008): NEDPLSMS/NEOPL AGNTS-BLOOD,RES(*24010); TISS CULTURE-APPARAT,- ME THS,MED IA(32500); IN VITRO STUDS-CELLULR.SUBCELL!32600); CHEMOTHERAPY-GEN STUD,METH,METAB(*38502); PLANT PHYSIOL-CHEM CONSTIlUENTS!5 1522 ) ; PHARMACOGNOSY/PKARMACEU t BOTANY ( 54000) B f osys temat 1c Codes: PLANTAE-UNSPECI F I F.0( 1(000 ) : MURIDAE(8G375 ) (RECO. 1981). 253-261. Codon: UIIEMA Language: ENGLISH To assess the process of oxidation and conjugation involved In biotransformation of vinyl chloride (VC), rats were exposed to 50. 200. 500.. 1OO0 and 20.000 ppm Inhaled VC. Rato of urinary excretion of thIodIg1yco11c acid (TOGA) after exposure to each Investigated concentration of VC depended on activity of mlcrosoma1 monooxygenase. H1gher levels of TDGA In urine were reflected by a more significant depression of non-protein SH content In liver of rats. No changes were observed In rats with Inhibited activity of microsomal monooxygenase and depressed urinary levels of TDGA. The significance of alcohol dehydrogenase in metabolism of low concentrations of VC was not confirmed. Metabolism of VC In the range 50-2000 ppm was mediated by microsomal monooxygenase followed by conjugation with thiols. Descriptors: MICROSOMAL MONO OXYGENASE SULFHYDRYL LIVER Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506 ) ; COMPARATIVE BIOCIIEM-GENL S TUO I E S ( 10O 10 ) : BIOCHEM S IUO - G E NE R A L ( 10060 ) : BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACD(10064); ENZYMES-PHYS- I0L0G1CAL STUOIES(10808); ANATOMY/HISTOL-MICRO,ULTRAMICRSC( 1 - 1108); PATHOLOGY-COMPARATIVE!12503); METABOLISM-GENL STUD.MET AB PATHW( 13002); METABOLISM-PROTNS.PEPTDS.AM ACDS! 13012); DIGESTIVE SYST-GENL STUDS.METUS(14001); DIGESTIVE SYST-PATHOL OGY (* 14006); URIN SYST/EXT SECR-GEN STUD.METH! 15501); URIN SYST/EXT SECR-PATHOLOGY!15506); RESPIRATORY SYST-GENL STUD.METHS! 16001); ROUTES OF IMMUNIZ,INF EOT,THERAP(2210O); TOXICOL-GENL/EXP STUDS.METHS!*22501 ); TOXICOL -ENVlRONMNTL.INO- USTR(22506); NEOPLSMS/NEOPL AGNTS-CARC INOGENS(24007 ) ; ENVIRON HEALTH-AIR.WATR.SL P0LLN(37015) B1osys temat I c Codes: MURIDAE(86375 ) 72006773 URINARY EXCRETION OF THIO DI GLYCOLIC-ACID AND HEPATIC CONTENT OF FREE THIOLS IN RATS AT DIFFERENT LEVELS OF EXPOSURE TO VINYL CHLORIDE TARKOWSKI S; WISIEWSKA-KNYPL J M; KLIMCZAK J; DRAMINSKI W; WROBLEWSKA K DIV. OF INDUSTRIAL TOXICOL., INST. OF OCCUPATIONAL MED.. 90-950 LODZ. UL. TERESY 8. POLSKA. J HYG EPIDEMIOL MICRnpIDi TMMHMni fen*curt ~ "" DIALOG F ( I e 5 : BIOSIS Previews 77-83/d R&S 138394 1 e55 ) (c. BIOSIS 1982) litem 179 of 858) User 3614 25jan83 204 0 72006762 POLY VINYL CHLORIDE DERMATITIS NOT CAUSED BY PHTHALATES SCHULSINGER C; MOLLGAARO K SKT. PEDERSSTR. 43, 4 T.V., COPENHAGEN K, DK-1453 OENMARK. CONTACT DERMATITIS Coden: CODED 6 (7). 1980 (RECO. 1981). 477-480. Language: ENGLISH Seven cases of contact dermatitis In children due to Identification bracelets made of polyvinyl chloride (PVC) plastic are reported. Patch tests with the bracelets were negative In the 5 cases tested. The irritant reactions were due to some unknown chemical In the bracelets. The most widely used plasticizers In PVC, phthalates, must have very low sensitizing properties, as only 1 positive patch test was found In 1532 patch tests with phthalate mix, performed as a joint study by the International Contact Dermatitis Research Group. Descriptors: CHILDREN IDENTIFICATION BRACELET SENSITIZING PROPERTIES IRRITANT REACTION INTERNATIONAL CONTACT DERMATITIS RESEARCH GROUP PATCH TEST Concept Codes: GENL BIOL-INST I TUT.AOMIN,LEG ISLN(00508); BIOCHEM STUO-GENERAL(10060); PATHOLOGY - INFLAMMATN.INFLAM DISC 12508); PATHOLOGY-THERAPY( 125 12); INTEGUMENT SYST-GENL STUDS,METHSf 18501 ); INTEGUMENT SYST-PATHOLOGY(* 10506 ) ; ROUTES OF IMMUNIZ,INFECT,THERAP(22100); TOXI COL-GENL/EXP STUDS.METHS- (*22501): PEDIATRICSt*25000); IMMUNOL/IMMUNOCHEM-GEN METH(345- 02); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(34 508); ALLERGY{* 35500) Biosystematic Codes: HOMINIDAE(86215) 72006664 EXPERIMENTAL STUDIES ON THE CHRONIC TOXIC EFFECTS OF VINYL CHLORIDE IN RATS SOKAL J A; BARANSKI B; MAdKA d; ROLECKI R; STETKIEWICZ d; IVANOVA-CHEMISMANSKA L; VERGIEVA T; ANTONOV G: MIRKOVA E; ET AL INST. OF OCCUPATIONAL MED., 90-950 LODZ, P.O. BOX 199 POLAND. d HYG EPIDEMIOL MICROBIOL IMMUNOL (PRAGUE) 24 (3). 1980 (RECD. 1981), 2B5-294. Coden: dHEMA Language: ENGLISH Male rats were exposed to vinyl chloride at concent ra tIons of 50, 500 and 20,000 ppm, 5 h dally, 5 days/wk for 10 mo. Morphological 1esIons In liver and testes detected by light and EM and depression in body weight increase Inlens if led with duration of exposure. Increased relative weights of some organs and slight hemato1ogIca1 and blochemleal changes In blood were also observed. Some toxic effects Including morphological liver Injuries arose at the smallest exposure level (50 ppm). Assuming 50 ppm as thereshold concentration for rats, 5 ppm level' was estimated as safe exposure limit In industry in relation to systemic effects of vinyl chloride. Descriptors: BLOOD LIVER TESTES WEIGHT LOSS OCCUPATIONAL HEALTH INDUSTRIAL TOXICITY Concept Codes: GENL BIOL - INSTI TUT.AOMIN.LEGISLN(00508): MICRDSCOPY-GENL.SPECL TECHNI0UES(01052); ELECTRON MICROSCOPY(01058): C Y TOLDG Y / C YTOCHFM - ANIMAL f 05 506 1 RtflOIFM CTdn-nrurnM - ( 10060) ; PATHOLOGY-GENERAL STUDIES{ 12502) ; PATHOLOGY-COMPA HAT- IV( 12503): METABOLISM-GENL STUO.METAB PATHW( 13002 ) ; DIGESTIVE SYST-GENL STUOS.METHS( I 4001): DIGESTIVE SYST-PATHOLOGY( t4006 ) ; BLDOD/BODY F LDS ;BLD . LYM, RES P ATH ( * 15006 ) : RE PRODUCT SYST-GENL STUDS,METHS{16501); REPRODUCT SYST-PATHOLOGY(*16506) ; TOXICOL-ENVIHONMNTL. INDUSTR{*22506); ENVIRON HEALTH-OCCUPAT- NL HEALTHt*37013) ; ENVIRON HEAL1H-A IR,WATR.SL P0LLN(370I5) B losys temat tc Codes: MURIDAE{86375) 72004253 CHEMO THERAPY OF VINYL CHLORIDE ASSOCIATED HEPATIC ANGIO SARCOMA OANNAHER C L; TAMBURRO C H; YAM L T COLUMBUS HOSP. REG. ONCOL. CENT., P.O. BOX 5013, GREAT FALLS, MONT. 59403. CANCER (PHILA) 47 (3). 1981. 466-469. Language: ENGLISH Coden: CANCA The use of systemic chemotherapy was s tudled 1n a group of 4 patients who had hepatic angiosarcoma In association with exposure to vinyl chloride. All patients received adrlamycin 60 mg/m2 l.v. every 3-4 wk. in 3 patients this was combined with cytoxan 600 mg/m2 and methotrexate 20 mg/m2. Three patients had an objective response lasting 4. 9 and 10 mo. One patient had stable disease for 10 mo. Responding patients maintained an excellent performance status during therapy. Following evidence of progressive disease, patients died in 3. 4 and 6 mo. Survival from the time of diagnosis was 11, 13, 15 and 53+ mo. Sufficient data are not available from these patients to recommend a specific drug or combination for use In hepatic angiosarcoma; chemotherapy apparently can Improve qua 1 1 ty and duration of survival. Descriptors: HUMAN ANTINEOPLASTIC-DRUG ADRIAMYCIN CYTOXAN METHOTREXATE Concept Codes: GENL BIOL-INFRMTN,OOCU.COMP APPL(00530); BIOCHEM STUD-GENERAL( 10060) ; BIOCHEM STUD-V ITAMINS( 10063 ) ; PATHOLOGY-DIAGNOSTIC( 12504 ); PATHOLOGY-NCROSIS( 1 2S 10 ) ; PATHO LOGY - THERAP Y ( 12512); DIGESTIVE SYST-PATHOLOGY( 14006 ) : CARD IOVASC SYST-GENL STUDS,METHS{l4501 ); CARDIOVASC SYST-BLO VESS PATHOL(* 14 508 ) ; PHARMACOL-CL INICAL PHARMACOL(2 2005); PHARMACOL - CARDIOVASC S YST { * 220 10 ) ; PHARMACOL - 0 I C.E ST I VE SYST( *22014 ); ROUTES OF IMMUNIZ.INFECT.THE RAP(22100 ) : TOXI COL-ENVIRONMNTL,INDUSTR(*22506) ; NEOPLSMS/NEOPL AGNTS-OIA- C.NS METIK 24001 ) ; NEOPLSMS/NEOPL AGNTS-C ARC I NOGENS ( *2 4007 ) ; NEOPLSMS/NEOPL AGNTS-THERAP.AGNT(*240OB); ENVIRON HEALTH-OCCU- PATNL HEALTHt37013): CHEMOTHERAPY-GEN STUD,METH.ME TAB{*38 502) Biosystematic Codes: |iOM INI DAE ( 862 15 ) D I A L Oi 1 e5 : BIOSIS Previews 77-83/Jan R&S 138395 72003902 ANGIO SARCOMA OF THE PENIS WITH HEPATIC ANGIOMAS IN A PATIENT WITH LOW VINYL CHLORIDE EXPOSURE GHANDUR-MNAYMNEH L; GONZALEZ M S DEPARTMENT OF PATHOLOGY. UNIVERSITY OF MIAMI SCHOOL OF MEOICINE. 161 i N.W. I2TH AVE.. MIAMI. FL. 33136. CANCER (PHILA) A 7 (6). 198 1. 1318-132-1. Coden: CANCA Language: ENGLISH A case of angiosarcoma of the penis associated with 2 hepatic angiomata In a 61 yr old man is presented. The patient had worked in a polyvinyl chloride factory as an accountant for 10 yr. The relationship of this low vinyl chloride exposure to the development of the vascular lesions is discussed with a review of the experimental and epidemiologic data on this subject. Descriptors: FACTORY WORKER CARCINOGEN Concept Codes: BIOCHEM STUD-GENERAL(10060); DIGESTIVE S YST - PATHOLOGY ( * 1 -1006 ) : CARDIOVASC SYST-BLD VESS P ATHOL (* 1A 50- 8): REPROOUCT SYST-PATHOLOGY(* 16506); TOXICOL-ENVIRONMNTL;!NO US TR(* 22506); NEOPLSMS/NEOPL AGNTS-CARC INOGENS(* 24007); GERONTOLOGY{24500); ENVIRON HEALTH-OCCUPATNL HALTH{37013) BlosystematIc Codes: HDMINIDAE{86215) ) (c. BIOSIS 1982] (Item 1B2 of 858) User 3614 25j 204 SKIN CLIN.. FREDERIKSSUNDSVEJ 112. 2700 RRONSHOJ, DENMARK. CONTACT DERMATITIS 6 (7). 1980 (RECD. 1981). 452-454. Codon: COOED Language: ENGLISH In 2 patients, urticaria was elicited by contact with N i-conta 1 n 1 ng objects. Chamber-prick testing with N ( S04 2.5 7. in petrolatum evoked a strong urticarial reaction In both patients. In ! of the patients contact with plastic articles also provoked urticaria. A 20 min patch test with several/ plastic articles (polyethylene and PVC [polyvinyl chloride)) and with butyI hydroxy to 1uene (BHT) t% In ethanol el lotted urticarial reactions. BHT Is used as an antioxidant In plastic. Open patch test with oleylamfde (amide of oleic acid) 0.1% In ethanol elicited a strong urticarial reaction in 20 min. This chemical is used as a slipping agent In plastic. Descriptors: HUMAN POLY ETHYLENE POLY VINYL CHLORIOE ANTI OXIDANT SLIPPING AGENT CHAMBER PRICK TESTING Concept Codes: BIOCHEM STUD-GENERAL(10060); MINERALS(10069); PA 11 IOLOGY-INF L AMMAT N,INFLAM DIS( 12508): INTEGUMENT SYST-GENL STUDS,METHS( 18501); INTEGUMENT SYST-PATHOLOGY( * 18506): ROUTES OF IMMUNIZ.INTECT,THERAP(22100); TOXI COL-GENL/EXP STUDS.METHS' ('22501): IMMUNOL/IMMUNOCHEM-GEN METH{34502); IMMUNOL/IMMUNOC- HEM-IMMUNOPATHOL(34508): ALLERGY(*35500) BtosystematIc Codes: HOMINIDAE(862 1 5 ) 72003890 RETENTION OF VINYL CHLORIDE IN THE HUMAN LUNG KRAJEWSKI J; DOBECKT M; GROMIEC J . OEP . CHEMICAL AIR POLLUTANTS INST. OCCUPATIONAL MED., LODZ. POLAND. BR d INO MED 37 (4). 1980 (RECD. 1981). 373-374. Coden: 8JIMA Language: ENGLISH Experiments with volunteers showed that 427. of an Inhaled dose of v.lnyl chloride [a carcinogen] was retained in the lungs. This value was Independent of concentration of vinyl chloride in the air. Elimination of vinyl chloride through the lungs was negligible since Its concentrat1 on In expired air decreased Immediately after cessation of exposure. Descriptors: CARCINOGEN AIR POLLUTION Concept Codes: CY7OL0GY/CYTOCHEM-HUMAN(O25O8); ECOLOGY-BIOC- LIMATOL,BIOMETEOROL(07504); COMPARATIVE BIOCtIEM-GENL STUDIES(- 10010): B10CHEM-GASES{10012): BIOCHEM METH-GENERAL(10050); BIOCHEM STUD-GENERAL{10060); PATHOLOGY-DIAGNOSTIC(12504); META80LISM-GENL STUD.METAB PATHW{ 13002): RESPIRATORY SYST-GENL STUD,METHSt16001); RESPIRATORY SYST-PATI IOLOGY (* 1 6006 ) ; ROUTES OF 1MMUNIZ.INT EC(.THERAP(22 100): TOXI COL -ENVIRONMNTL,IN0US1R(- 22506): NEOPLSMS/NEOPL AGNT S-CARCINOGENS(2 4007); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); PQLLN('37015) ENVIRON HEALTH-A IR,WATR.SL BlosystematIc Codes: HOMINIOAE(86215) 71084057 ESTIMATING THE AIR EMISSIONS OF CHEMICALS FROM HAZARDOUS WASTE LANDFILLS TNIBOOEAUX L J DEP. OF CHEM. ENGINEERING. COLL. OF ENGINEERING. UNIVERSITY OF ARKANSAS. FAYETTEVILLE. AR 72701, U.S.A. J HAZARD MATER 4 (3). 1981. 235-244. Coden: JHM60 Language: ENGL ISH A comprcliensIve landfill cover vapor transport model capable of assessing the diffusive and convective transport mechanisms for toxic chemical air emission calculations was developed. Sample calculations of rates for worst-case scenarios Involving benzene, chloroform, vinyl chloride and Aroclor 124B provided some Insight Into the magnitude of the environment Impact of an Insecure chemical waste landfill on surrounding air quality. An algorithm was presented for obtaining crude exposure 1 eve 1s. Descriptors: BENZENE CHLOROFORM VINYL CHLORIOE ARDCLOR 1248 LANOT ILL COVTR VAPOR TRANSPORT MOOEL SEWAGE AIR POLLUTION Concept Codes: MATHEMATIC BIOL/STATISTIC ME 111(04500): ECOLOGY - BIOCUMATOL .El IDME TEOROL (07504 ) ; COMPARATIVE BIOCHCM-G- ENL STUD IE S( 10010): BIOCHEM-GASES( 10O12) : BIOCHEM MET1I-GENERAU10050); BIOCHEM STUO-GENERAL(10060): BIOPHYS-BIO- CYBERNETICS< 10515); TOX I COL -ENVIR0NMN1L. JNOUSTR< 22506); ENVIR ON HE ALT 11 -SEWG DISP,SAN ITAR(* 37014 ) ; ENVIRON HEALTH-A IR.WATR . - SL POLLN(*37015); SOIL SC I-PHYSICS.CHEMI STRY(52005) 72000124 CONTACT URTICARIA FROM NICKEL BUTYLHYDROXY TOLUENE OLEYLAMIDE OSMUNDSEN P E AND PLASTIC ADDITIVES DIALO le5: BIOSIS Previews 77-83/dan BA75( R&S 13839^ (c. BIOSIS 1982) (Item 186 of 858) User 3614 25Jan83 2042 710770)9 EPIDEMIOLOGICAL STUDY OF RESPIRATORY DISEASE IN WORKERS EXPOSED TO POLY VINYL CHLORIDE DUST SOUTAR C A; COPLAND L H; THORNLEY P E; HURLEY J F; OTTERY J; ADAMS W G F; BENNETT B INST. OCCUPATIONAL MED., ROXBURGH PL., EDINBURGH EH8 9SU. THORAX 35 (9). 1980. 64 4 -6 52. Language: ENGLISH Codon: THORA Respiratory heaIth of workers exposed to polyvinylchloride (PVC) dust was Investigated In 818 men sampled from the work force of a factory manufactur1ng PVC. In a cross-sectional survey, lung function and prevalences of respiratory symptoms and chest radiographic abnormalities wore compared with estimates of Individual PVC dust exposures based on detailed occupational histories and current measurements of respirable PVC dust. Complaints of siIght exertional dyspnea were associated with PVC dust exposure, though age and smoking effects were much stronger. Forced expired volume in i sec. (FEV1) and forced vital capacity (FVC) worn Inversely related to dust exposure after age, height and smoking effects were taken Into account. This effect was seen principally In cigarette smokers and there was suggestive evidence that PVC dust exposure and cigarette smoking interacted In reduction of FEV1 and FVC. Gas transfer factor was not related to dust exposure. Chest radiographs wore performed. One reader recorded a low prevalance of small rounded opacities not related to age or dust exposure. Another reader recorded a higher prevalence of small rounded opacities category o/l or more related to age but not to dust exposure. The 3rd reader recorded the highest prevalence of small rounded opacities (though none greater than category 1/t) and these were 1ndependent1y related to age and PVC dust exposure, indicating an effect of PVC dust on appearances of chest radiograph. These appearances were so slight, that only the higher sensitivity of this reader In the interpretation of profusion of small rounded opacities enabled detection of this effect of PVC dust. Exposure to PVC dust was associated with some deterloratIon of lung function, slight abnormalities of chest radiograph and complaints of slight dyspnea. Mean decline in FEV1 associated with average dust exposure was small, though some men with higher dust exposures suffered clinically important loss of lung functIon as a result of their occupa t ton. Descriptors: HUMAN DYSPNEA SMOKING AGE AIR POLLUTION OCCUPATIONAL HEALTH Concept Codes: PHOTOGRAPHY-METHS.MATLS.APPARAT{010i2); CYTOLOGY/CYTOCHEM-HUMAN(02508); MATHEMATIC BIOL/STATISTIC METM(O'ISOO) : SOCIAL BIOL/HUMAN ECOLOGY (05500) ; RADIATION BIOL-RADTN,ISOTOP TECH(06504); BEHAVIOR BIOL-HUMAN 0EHAVIOR{07004); BIOCHEM STUD-GENERAL( 10060 ) ; ANATOMY/HISTOL-- COMPARATIVE(11 103) : ANATOMY/HISTOL-RA0IOLOGIC(11106); Cl I0RDATE BODY REGNS-THORAX( 1 1312); PATHGLOGY-COMPARATIVE( 12503 ) ; PATHOLOGY-DIAGNOSTIC 12504); MET ABOLISM-GLNL STUD,ME T AB PATHW(13002): RESPIRATORY SYST-GENL STUD,METHS(16001): RESPIRATORY SYST-PATH0L0GY(* 16006); PSYCH!ATRY-ADD ICT10N(INC SMOKNG)(2i004); ROUTES OF IMMUNIZ,INFECT,THERAP(22100): TOXICOL-GENL/EXP STUDS,METHS(*2250 I); TOX I COL-ENVIRQNMNTL, IND US t R ( * 2 2506 ) ; DEVELDPMNTL BI0L-GEN.MORPHGENSIS(25508); PUB HEALTH-ADM INI STR,ST AT I ST ICS ( 370 IO): ENVIRON 11ALTH-OCCURATNL HEAL1H( * 37013); ENVIRON MEALTH-A 1R,WATR,SL POLLN( -37O15): E PI I) EMI 111.- MISCELL STUD IES(*37056) ; PLANT PHYSlOL-CHfcM CONSTITUENTSt5 1522 ) : AGRONOMY - TOBACCO CR0PS(52512) 8 losystematIc Codes: SOLANACEAE(26775); MOM INIOAE(86215) 7 107554 I THE ADAPTABILITY OF POLY VINYL CHLORIDE BAGS IN THE FLUID THERAPY OF FIELD MEDICINE CEDERBERG A; LEVANEN d; TIKKA S A; ROKKANEN P KESKUSSOTI I.ASSA1RAALA 1, PL 105, 00251 HELSINKI 25. SOT ILASLAAK AIKAK 5 5 (3). 19 80 (RECO. 1981). 120-124. Coden: SOAI A Language: FINNISH One of the most Important procedures In field medicine In catastrophic situations during the war and peace time is to organize efficient fluid therapy. Most essential Is the packing material of Infusion fluids. PVC[po1yv1nyI ch1 or 1 do)-bags made in Finland wore tested in field conditions. The Infusion was carried out in typical . Finnish field conditions to anesthesized pigs which were wounded by shooting. The infusion was started at the site of the shooting and it was continued during the transportat1 on. at the battalion aid station and In the field hospital. The bags were suitable In size and shape, which made their handling easy. The readiness to start Infusion was reached without delay, due to easy insertion of infusion tubes. PVC bags and tubes are easily transported with the patient, e.g.. example by putting the bag and the tubes In the patient's clothing. Despite rough handling, there was no bag breaking. Keeping the fluid warm in combat exercises proved successful by putting the bag under the arm of the patient. High pressure infusions are easy to carry out. The danger of air emboli is avoided by sucking the air out of the bag. The use of PVC bags In field medicine enables an efficient use of fluid therapy during the war and In peacetime disasters. The plastic material is light and easy to handle and It requires minimal storage space. Descriptors: HUMAN PIG FINLAND AIR EMBOLISM Concept Codes: GENERAL FIELD METHODS{01008); SOCIAL BIOL/HUMAN ECOLOGY(05500); BIDCHEM-GASES(tOO12); BIOCHEM STUD-GENERAL( 10060): EXTERN EFF-PHYSICAL,MECH EFFECTS(* 10612); ANATOMY/HISTOL-REGEN.TRANSPLANT(11107); CHORDATE BODY REGNS-E- XTREM1TIES( 1 1318); PHYSIOLOGY- INSTRUMENTATI0N(* 12004); MOVEME- NT( 12100) : PATHOLOGY-GENERAL STUDI S(* 12502); PATHOLOGY - THERA - PY( 12512): INUTR TION-PROPHYLAC,THERAP 01ETS( 1 32 1 0 ) : CARDIOVA- SC SYST-BLD VESS P A THOL ( * 14 508 ) ; NERVOUS SYST-C.ENL STUDS.METHS(20501): PHARMACOL-NEUROPHARMACOLOGY(22024); TEMPE RATURE - GENL . ME THS (* 2300 1 ) ; PUB HEALTH-HEALTH SERV.MEOL CARE(37012) Bfosystemat1c Codes: SUIOAE{85740): MOMINIOAE(86215) DIAL If!e5: BIOSIS Previews 77-83/Jen BA7502;RRM2- R&S 71074995 HEM ANGIO SARCOMA OF THE LIVER AND SPLEEN MANIFESTED BY HIGH OUTPUT HEART FAILURE AND CONSUMPTION COAGULOPATHY HO K-J; ZAKI S; SCULLY K T OEP. PATHOL., UNIV. ALA., BIRMINGHAM. ALA.. USA. ALA J MED SCI AJOMA 17 (1). 1980 (RECD. 1981). 27-31. Coden: Language: ENGLISH A case of a 60 yr old black male with massive liver, and splenic hemnng1osarcoma Is reported. The patient presented with high output heart failure. The clinical course was complicated by disseminated Intravascular coagulation (DIC) and bleedi'ng diathesis, which resulted in repeated episodes of intraabdomIna1 bleeding. He died from renal insufficiency and terminal massive bleeding from the tumor. The 2 most outstanding clinical features in this case. namely the high output heart failure and DIC. could be explained by the nature of the tumor: its function as an arteriovenous shunt and Its Irregular. abnormal, neoplastic endothelium and Kupffer's cells. Despite Its rare occurrence, in the presence of an unexplained high output heart failure with DIC arid hepatomegaly, hemang1osarcoma of the 1Iver should be Included In the differential diagnosis. particularly in those patients with a past history of prolonged exposure to [the carcinogensJ vinyl chloride, thorotrast or arsenic. Descriptors: HUMAN VINYL CHLORIDE THOROTRAST ARSENIC CARCINOGEN DIAGNOSIS Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(O25O0); BIOCHEM STUD-GENERAL( 10060); MINEHALS( 10069) ; CHOROATE BODY R E GNS-ABDOMEN( t 13 14); PATHOLOGY-NECROSIS( I 25tO); DIGESTIVE SYST-PATHOLOGY(* 14006); CARDIOVASC SYST-8LD VESS PATHOL(* 1450- 8); BLOOD/BODY FLOS-BLD.LYM.RES PATH(* 15006); BLOOD/BODY FLOS-LYMPHAT TISS.RES(15008); URIN SYST/EXT SECR-PATHOLOGY{ 15 - 506): T OX ICOL -GENL/EXP STUDS.METHS{22501); NEOPLSMS/NEOPL AGNTS-DIAGNS METH(* 24001 ); NEOPLSMS/NEOPL AGNTS-PATH,CL INIC(*- 24004); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007) Blosystemat tc Codes: HOMINIOAE(862 15) 7 1074072- INHIBITION OF BABESIA-SPP BY PLASTICS TIMMS P OUEENSL. OEP. PRIMARY INDUST.. ANIM. RES. INST., TICK TEVER RES. CENT., WACOL. OUEENSL. 4076, AUST. APPL ENVIRON MICROBIOL A EMI 0 41 (1). 1901. 17-19. Coden: Language: ENGLISH Five commercially available plastic containers [used in vaccine preparatfon] were compared with glass for toxicity toward 8 . rodha ini and 8 . b I gem Inn. Cnmpnr Isons worn made by using infectlvlty tests in mica (8. rodhalni) and cattle (B. bigemlna). Low-density po!ypropy1 one and polystyrene containers were not toxic but 2 of the 3 polyvinyl chloride containers tested significantly reduced the viability of both species of Babesia. Plasticizer present In various amounts on the surface of the toxic containers was most likely the InhIbitory material. SIS 1982) (Item 188 of 858) User 3614 25jan83 2043 Descriptors: BABES IA-RODHAfNI BABES I A-BI GEM INA MOUSE BOVINE POLY VINYL CHLORIDE POLY PROPYLENE POLY STYRENE TOXICITY VACCINE Concept Codes: BIOCHEM STUD-GENERAL(10060): BLOOD/BODY FLDS-BLD.LYM.RES PATH( 15006); TOXICOL-GENL/EXP STUDS.METHS(* 2 - 2501): TISS CULTURE-APPARAT.METHS.MEDIA(*32500); IMMUNOLOGY-P- ARASITOLOGICALt*35000); VETERINARY SCI-PATHOLOGY(38004); PARAS ITOLOGY-VETER1NARY(60506): INVERTS PHYSIOL-PROTOZOA(* 64002 ) 8losystemat(c Codes: SP0R0Z0A(354OO); BOVIOAE(857 !5 ) : MURIDAE(86375) 71071509 ACRO OSTEOLYSIS REPORT OF 2 CASES AND BRIEF REVIEW OF LITERATURE KAUR S; KUMAR B; CHOPRA J S; LAMBA G; NARANG A DEP. DERMATOL.. CHANDIGARH. INDIA. POST-GRAD. INST. MED. EDUC. RES.. CLIN NEUROL NEUROSURG 82 (1). 1980. 45-56. Coden: CNNSB Language: ENGLISH Siblings (2) with acro-osteo1ysis. a rare disorder, are discussed. Although 3 distinct types of acro-osteo1ysts. i.e,. familial. idiopathic and due to vinyl chloride, are clearly defined. these patients did not fit into any category. They had intact nails, preserved tactile and sensory system, plantar ulceration and no sensory deficit. Nerve conduction studies showed prolongation of motor distal latencies In median, ulnar. posterior tibia) and lateral popliteal nerves. Nerve biopsies from both patients showed severe loss of myelinated fibers of all sizes, but more so of small ones. Descriptors: HUMAN MYELINATED TIBER LOSS VINYL CHLORIDE PLANTAR ULCERATION Concept Codes: CYT0LDGY/CYT0CHEM-HUMAN(O2508); GENET[CS/CYT- DGENET-HUMAN!03508): BIOCHEM STUO-GENERAL(10060); BIOCHEM STUO-CARBOHYDR.( 10068); CHORDATE BODY REGNS-EXTREMIT I ES( 1 I 3 1 8 ) ; PATHOLOGY-DIAGNOSTIC( 12504); PATHOLOGY - 1NFLAMMATN,INFLAM DISC 12 508); METABOLISM-CARBGHYDRATES(* 13004); METABOLISM - LIPI - DS( 1 3006 ) : METABOLISM-PROTNS,PEPTDS.AM ACOS(*13012): MUSCLE SYST-PATHDLOGY( 17506); BONE.JNTS.FASC.CONN/AD IP-PATHOL( 1800GI INTEGUMENT SYST-GENL STUDS.METHS(18501>: NERVOUS SYST-GENL STUOS,ME T HS[20501) ; NERVOUS SYST-PATHOLOGY{*20506): TOXICOL-GENL/EXP STUDS,METHS(2250t) 8losystemattc Codes: HOMINIOAE(86215) DIALO 1 e5; BIQSIS Previews 77-83/Jan BA7502-.RR R&S 13 8 3I0STS 19 B 2) (Item 191 of 858) User 3614 25jan83 204 4 7 1070-180 PESTICIDE ACTIVITY OF FOODS EXPOSED TO NALED OR DICHLORVOS POLY VINYL CHLORIDE RESIN FORMULATIONS GREENBERG J; GOULDING R L A.H. ROBINS CO. RES. LAB., RICHMOND, VA. 23220, USA. J STORED PROD RES Coden: JSTPA 16 {3-4). 1980 (RECD. 1981). 159-162. Language: ENGLISH Raw hamburger, fruits, vegetables and bread were exposed to a 25% na1ed-polyv1ny1 chloride resin formulation and a comparable commercial 20% dlchlorvos formulation In test cells for 24 h. Relative pesticide activity was determined by bioassay (LT50) against male SRS susceptible houseflies (Musca domesttca). Activity in samples exposed to dlchlorvos was 11-16 times greater than that In comparab1e na1ed samples and treatments. Since housefly topical LD50 values for these 2 organophosphates were near 1y similar, a much smaller res I due of naled was Indicated by greater LT50 of food exposed to this pes t1c1de. Descriptors: MUSCA-DOMESTICA FLY FRUIT VEGETABLE HAMBURGER BREAD FOOD TOXICITY INSECTICIDE Concept Codes: COMPARATIVE BIOCHEM-GENL STUDIES(10010): BIOCHEM METH-GENERALC10050): BIOCMEM STUD-GENERAL(10060); PATHOLOGY-COMPARAT IVE( 12 503); PATHOLOGY-NECROSIS( 12510): META- BOLISM-GENL STUD,METAB PATHW{ 13002 ) ; NUIRITION-PATHOGENIC DIETS( 13216): FOOD TECH-FRUITS,NUTS,VEGETABLES(* 13 504); FOOD TECH-MILLING TECHNOLOGY(* 13506); FOOD TECH-BAKING TECHNOLOGY(- *13508); FOOD TECH-MEAT.MEAT BY-PRODUCTS( 1 35 16) ; FOOD TECH-EVALNS PHYS.CHEM PROPS( 13 530): TOXI COL-GENL/EXP STUOS,METHS{*22501); TOXICOL-F000,RESIDS.ADD IT.PRESRV(* 22502); FOOD/1 NOUS MICRO-FD/BEV SP CNTAM(39002); PEST CONTRL GENL/PESTICS/HERBICS(*54600): ECONOM ENTOMOL-CHEM PHYS CONTRL{*60016); INVERTB PHYSIOL-I NSEOTA-PHYSIOL{*64076) Blosystematic Codes: PLANTAE-UNSPECIFIED( 1 1000); DIPTERA(75- 314); VERTEBRATA-UNSPEC1F1ED(05150): ABSTRACTS OF ENTOMOLOGY(96000) CHICKEN MILK EGG MEAT VEGETABLE OIL MACARONI CHEESE BUTTER BREAD NEGLIGIBLE TOXICITY TOLERANCE LEVEL Concept Codes: GENL BIOL- INSTI TUT.ADMIN,LEGISLN(00508 ) ; COMPARATIVE BIOCHEM-GENL STUDIES( 10O10): BIOCHEM METH-GENERAL- (10050); BIOCHEM STUD-GENERAL(10060); EXTERN EFF-HOT( 106 1 8 ) : PATHOLOGY-COMPARATIVE{ 12503); NUTRITION-PATHOGENIC 0IETS{1321- 6): FOOD TECH-FRUITS.NUTS.VEGETABLESt13504); FOOD TECH-MILLING TECHNOLOGY(* 13506); FOOD TECH-FATS,0 ILS( * 1 35 1 4 ) ; FOOD TECH-MEAT,MEAT' BY-PRODUCTS(*13516); FOOD TECH-DAIRY PRODUCTS( * 135 18 ) ; FOOD TECH-PDULTRY,EGGS(* 13520); FOOD TECH-EVALNS PHYS.CHEM PROPS( 1 3530); FOOD TECH-PREP.PROCESSNG.- STORAGE( 13532); TOX I COL-FOOD.RES IDS.ADD IT,PRESRV(*22502); TEM PERATURE -GENL.METHS(2300l); ENVIRON HEALTH-AIR,WATR . SL POLLN(37015); FOOD/INOUS. MICRO-FD/BEV SP CNTAM(39002); AGRONOMY-GRAIN CROPS(52504); HORTICULT-TROP FRUIT.NUT.PLANTAT- (53004); HORTICULT-SMALL FRUITS(53006); HORTICULT-VEGETA8LES( - 53008); PEST CONTRL GENL/PEST ICS/HERBICS{* 54600); ECONOM ENTOMOL-CHEM PHYS CONTRL(60016) Blosystemat1c Codes: ANGIOSPERMAE-UNSPECIF1 ED(25200); GRAMINEAE{2 5305) ; CHENOPODI ACEAE(25795); RUTACEAE(26685 > ; SOLANACE AE(26775) ; VITACEAE{26940); GALL I FORMES(85536 ) ; ABSTRACTS OF ENTOMOLOGY{96000) 71070479 NALED ANALYSES OF FOODS EXPOSED TO 25 PERCENT NALED POLY VINYL CHLORIDE FLY DISPENSER . GREENBERG J; POLLOCK R J A.H. ROSINS RES. LAB., RICHMOND. VA. 23220, USA. J STORED PROD RES Coden: JSTPA 16 (3-4). 1980 (RECD. 1981). 155-158. Language: ENGLISH Foods were exposed for 1,3 or 24 h In an atmosphere of 2 ng/l naled produced from 25% nated-PVC [polyvinyl chloride) fly dispensers In a room of 43.6 m3. After 24 h no residues wore do toe tod In sliced tomato or grapes and after 3 h no res 1 dims wore found In milk, grape f ru It, po t n t o . linn l on ogg , cooked rice.' chicken pie or chopped meat. After 1 h residues of 0.06 ppm or less were found 1n vogetab1e oil, cooked rice, cooked spinach and macaroni cheese but were not detectable in bread or butter. When residues were found, levels wore well below official tolerances permitted in USA. Descriptors: 'SPINACH TOMATO GRAPE GRAPEFRUIT POTATO RICE DIALOG FI 1e5: BIOSIS Previews 77-83/Uan BA7502;RRM2402<See F &S 138399 ) (Item 193 of 858) User 3614 25janS3 2045 7 1070'! 3 1 PULMONARY MANIFESTATIONS OF VINYL CHLORIDE AND POLY VINYL CHLORIDE INTERSTITIAL LUNG DISEASE NEWER ASPECTS CORDASCO E M; DEMETER S L: KERXAY J; VAN ORDSTRAND H S; LUCAS E V; CHEN T; GOLISH J A 9500 EUCLID AVE.. CLEVELAND 44106. CHEST 78 (6). 1980 (RECD. 1981). 828-834. Coden: CHETB Language: ENGL I SH Newer varieties of occupational lung diseases primarily due to Increased Industrial technology were reported. Preeminent among newer agents were vinyl chloride (VC ) and polyvinyl chloride. Few cases were reported, only In Europe, with descriptive his topa tho logic changes. No pathologic studies of VC exposure were described In USA literature. Biopsy abnormalities In patients disclosed desquamation of alveolar macrophages Into alveolar 1 urn 1na and minor Interstitial and alveolar inflammatory changes. Pulmonary function abnormalities included restrictive Insufficiency. Preventive therapy consisted of avoidance of further exposures, frequent 1ndustr 1 a 1 hyg1ene monitoring and total avoidance of tobacco smoke and associated atmospherIc pollutants. No patient hod exhibited evidence of pulmonary neoplasm. All 3 patients survived their occupattonal Injuries and 2 were still disabled to varying degrees. Urine and blood levels of phthalIc acid derivatives were elevated In 2 patients, exact significance was not fully known. It probably represented a toxicologic response. Descriptors: HUMAN TOBACCO SMOKE PHTHALIC-AC 10 PULMONARY NEOPLASM INFLAMMATION THERAPY OCCUPATIONAL HEALTH ENVIRONMENTAL TOXICITY Concept Codes: GENL BIOL-TXTBKS,EDUCATN.AUD-VIS{00514); CY TOLQGY/CYT OCHEM-HUMAN(02508); BEHAVIOR BIOL- HUMAN BEHAVIOR!- 07004); BIOCHEM-GASES! 10012 ) ; BIOCHEM STUD-GENERAU 10060): BIDPHYS-MOLECUL PROP.MACROMOLEC{10506); ANATOMY/HISTOL-MICRO,- UL T RA MICR SC( 1 1108): PATHOLOGY-COMPARATIVE( 12503): PATHOLOGY - I - NFLAMMATN. INFLAM 0IS( 12508); PATHOLOGY- THERAPY( 12512): METABOLISM-GENL STUD,MET AB PATHW( 13002); BLOOD/BODY FLOS-BLO,LYM.RES PATH!* 15006) ; BLOOD/BOOY FLOS-LYMPHAT TISS.RES( * 15008); URIN SYST/EXT SECR-GEN STUD.METH{15501): UR 1N SYST/EXT 5ECR-PATHOLOGY{* 15506); RESPIRATORY SYST-GENL STIJD. ME IHS( 1600 1 ) ; RESPIRATORY SYST -PAT110L0GY ( * 16006 } ; PSYCHIATRY-ADDICTION! INC SMOKNG)(21004 ); TOXI COL-GENL/EXP STUDS .ME THS( *2 2501 ) ; TOX I COL - ENVI RONMNTL .'I NDUST R( *22506) : NEO- PLSMS/NEOPL AGNTS-CARCINOGENS!*24007); ENVIRON HE ALTH-OCCUPAT- NL HEALTH!*37013); ENVI RON HEALTH-AIR,WAT 11.SL POLLN(37015); PLANT PHYSIOL-CHEM CONSTITUENTS{51522); - AGRONOMY-TOBACCO CROPS(52512) B tosystemat1c Codes: SOLANACEAE(26775); HOMINIDAE{86215) Coden: AJEPA Language: ENGLISH The epidemiologic Identification of occupational carcinogens 1s comp 1 lea ted by severa 1 problems Including worker mob I 1 I ty between Jobs. variation over time of chemicals and processes used, and the long 1 a tency period between exposure and discovery of a tumor. Considering these problems. a method using the cumulative dose concept was developed; this Involves calculating the expected year 1y exposure for each case from work histories of all noncases close to the case. In year of birth and year of hire. Data required for use of the method Include Information concerning exposure to the chemicals being studied for each Job in each calendar year of the study. Use of the method Is Illustrated with a s tudy of 1 Iver angiosarcoma and vinyl chloride exposure In a polymerization plant. The value of the method lies In the wealth of Information generated concerning the association between chemleal exposures and cancer.sbd.such as exposure level relationships, latency Information and the possibility that 2 chemicals might be acting Independently or Jointly. The serially additive expected dose mode! may prove particularly useful In the analysis of data collected by occupational health surveillance Systems, and In retrospective studies. Descriptors: HUMAN VINYL CHLORIDE CARCINOGEN LIVER ANGIO SARCOMA Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500); BIOCHEM STUD-GENERAL! 10060); B10PHYS-BIOCYBERNETICS(*10515): DIGESTIVE SYST-PATHOLOGY! * 14006): TOXICOL -ENVIRONMNTL.INDUSTR- {*22506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS!*24007); PUB HEALTH-ADMINISTR,STATISTICS(*37010); ENVIRON HEALTH-OCCUPATNL HEALTH!*37013); EPI0EMIOL-ORGANIC DIS.NEOPLASMS(*37054) B losystemat1c Codes: HOMINIOAE(86215) 7 10699 12 EPIDEMIOLOGIC INVESTIGATION OF OCCUPATIONAL CARCINOGENESIS USING A SERIALLY ADDITIVE EXPECTED DOSE MODEL SMITH A H; WAXWEILER R U; TYROLER H A DEP. COMMUNITY HEALTH, WELLINGTON CLIN. SCH. MED. , WELLINGTON HOSP., WELLINGTON 2, N.Z. All | f D 1 PiT MI D> * frN ipnh fprory i n f I \ 01 A LOG' 1e5: BIOSIS Previews 77-03/Jan 8A7502:RRM24Q2{See File 71064 4 G 4 EFFECT OF ROUGHNESS ON THE THROMBOGENICITY OF A PLASTIC HECKER 0 F; EDWARDS R 0 DEP. PHYSIOL., UNIV. N. ENGL., ARMIDALE. N.S.W. 2351, AUSTRALIA. J 8I0MED MATER RES 15 (1). 1981. 1-8. Coden: JBMRB Language: ENGLISH Tubings extruded from I batch of polyvinylchloride resin at 5 temperatures ranging from 110-205.degree. C were tested for thrombogen1c Ity In the saphenous vein and aorta of sheep. There was more thrombus In the vein and aorta on tubings extruded at lower temperatures. The surface areas of renal Infarction were smaller when lower temperature tubings were Inserted into the aorta. Scanning EM showed that lower extras Ion temperatures caused greater roughness on the tubings. This greater roughness was confirmed by roughness measurements. The association which was demonstrated between roughness and thrombus formation might be due to the degree of adhesion of the thrombus to the surface rather than to differences In thrombogen1cIty. Descriptors: SHEEP POLY VINYL CHLORIDE RESIN RENAL INFARCTION TEMPERATURE Concept Codes: ELECTRON MICROSCOPY{0 1058); BIOCHEM STUD-GENERAL(10060}: BI0PHYS-B10ENGINEERING(*10511): EXTERN EFF-TEMPERATUR(* 106 14); CARDIQVASC SYST-GENL STUDS.METHS(* 14 - 501): CARO I OVA SC SYST-BLD VESS PATHOL(14500); BLOOD/BODY FLDS-BLOOD,LYMPH STUD(* 15002}; URIN SYST/EXT SECR-PATHOLOGY(*- 15506} ; TEMPERATURE-GENL,METHS(2 3001) 81osys t ema tic Codes: 80VI0AE{85715) 71060825 BREAST CANCER FABRICATORS MORTALITY AMONG POLY VINYL CHLORIDE CHIAZZE L UR; WONG 0; NICHOLS W E; FERENCE I 0 DIV. OF BIOSTATISTICS AND EPIDEMIOL.. GEORGE 1 OWN UNIV. SCH. OF MED., WASHINGTON, DC 20007. J OCCUP MED 22 (10). 1980. 677-679. Coden: JOCMA Language: ENGL ISH A case-control analysis of breast cancer deaths among PVC [polyvinyl chloride] fabricators was presented. This study was an extension of a cross-sect!ona1 mortality study of deaths occurring among 17 PVC fabricators during 1964-1973. Relative risk estimates were' derived and tested using the Mantel-Haensze1 procedure. AI though no statistically significant relative risks were found, a least significant relative risk analysis Indicated that under lying relative risk would be on the order of 3:1 to be detected. There seemed to bo rcasonab1e assurance that largo 1nnronsns In risk for breast cancor' did not exist among these PVC fabricators. Descriptors: HUMAN OCCUP A I 1 ONA 1. HEALTH STATISTICS Concept Codes : C Y I OLOGY/C Y I 0C1 IE M-HUM AN ( 02 5011 ) ; MATHEMATIC DIOL/STAT 1STIC ME1H{04500); SOCIAL BIOL/HUMAN ECOLOGY(05500}; H I 001 IF M STUD-GENFRAL{ 10060) ; CHORDA IE BODY REGNS - (I I0RAX ( 1 t 3 I 2 ) PATI 10LOGY-COMPARAT IVE( 12503}; PATHOLOGY-NECR0S1S( 12510); METAB0L1SM-GENL ' STUD.ME TAB PATHW( 13002); REPRODUCT SYST-PATHOLOGY( * 16 506); TOX I COL -ENVIRONMNIt. . INDUSTR( *22506 1 : R&S 138400 ;tern 195 of 858} User 3614 25Jan83 2046 NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(*24007): PUB HEALTH-ADM 1NIST - H.STATISTICSt37010): ENVIRON HEALTH-OCCUPATNL HEALTH< * 370 1 3); ENVIRON HEALTH-AIR.WATR.SL POLLN(37015): EPI DEM IOL-QRGANIC DIS,NEOPLASMS(*37054) Blosystemat1c Codes: HOMINIDAE(86215) 7 1059764 A SIMPLE RAOIO IMMUNOASSAY TO DETERMINE BINDING OF ANTIBODIES TO LIPID ANTIGENS SMOLARSKY M DEP. OF CHEM. IMMUNOL.. WEIZMANN INST. OF SCI., REHOVOT. 1 SRAEL. J IMMUNOL METHODS Language: ENGLISH 38 (1-2). -1980. 85-94. Coden: JIMMB Lipids are not only Integral structural components of celt membranes, but they also carry 1mportant recognition determinants that have an Important role In various coll functions. social behavior and In the determination of their Immunogenic and antigenic properties. A solid-phase radioimmunoassay [RIA] to determine the binding of antibodies to lipid antigens Is described. Polyvinyl chloride microtiter plates were coa ted with lipid antigens by placing In each well 25-100 .mu.l of antigen solutions In ethanol and solvent evaporation. The wells were then washed with 0.3"/. gelatine solution to remove loosely bound antigens and to saturate the plastic with an Irrelevant protein to prevent unspecific ant(body binding to the plates. About 1/3 of [3M)phosphat1dy1cho1Ine adsorbed In this way (out of 1 nmol) was firmly at tached to the plastfc and was not washed away during a standard assay. The rest, loosely bound lipid, was washed away In the first 5 washings before the primary antibodies were applied. The technique Is rapid and convenient and is as sensitive as a conventional solid-phase RIA with protein antigens. It requires minute amounts of antigen. Less than 1 pmo1e of lipid antigen can be detected by this technIquo. Descriptors: PHOSPHATIDYL CHOLINE POLY VINYL CHLORIDE MICRO T I TER PLATES Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); RADIATION BIOL-RADTN.I SOTOP TECH(06504) ; COMPARATIVE BIOCI IEM-GENL STUD!ES(10010): BIOCHEM METH-GENERAL(10050}: BIOCHEM METH-PROINS.PEPTDS,AM AC( 10054): BIOCHEM METH-PORPHYRNS.8 ILE PIGM( 10055); BIOCHEM METH-LIP IDS( 10056); BIOCHEM STUD-PROTEIN- S.PEPTIDES,AMINO ACD(*10064); BIOCHEM STUD-LI F>!0S( 10066 ) ; BIOCHEM STUO-CARBOHYDR. ( 10068): BIDPHYS-MEMBRANE PHENOMENA( * t- 050B): IN VITRO STUDS-CELLULR.SUBCELL(32600): IMMUNOL/1MMUNOC- HEM-GEN METH( *34502): IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL( * 34508) B tosystema 11c Codes: VERTEBRATA-UNSPEC1F1ED{85150) R&S 138401 DIALOG F I 1e5 : BIOSIS Previews. 77-83/Jan BA7502;RRM2402(See F11e55) (c. BIOSIS 1902) (Item 16o of 85B) User 3614 25jan83 2047 71056313 EVALUATION OF ACUTE TOXICITY OF SMOKE AND GASES FROM SMOLDERING AND BURNING PLASTIC FORMS NISHIMARU Y; TSUDA Y; SAITO F DEP. LEGAL MED., YOKOHAMA CITY UNIV. SCH. MED.. 2-33 URAFUNE. MINAMI. YOKOHAMA 232, JPN. YOKOHAMA MED BULL Coden: YMBUA 30 (1-4). 1979 (RECD. 1980). 47-60. Language: ENGLISH Under estimated conditions of heating and air supply, various polymeric materials (polystyrene. polyvinylchloride, polyvrethana. urea resin and wood [Lavan]) were burned. Plastic foams were heated to temperatures corresponding to early stage of fire. Incapacitation time of mice and rabbits was taken as toxicity scale. Genera 11y, 1ncapac1tat1 on time decreased and toxicity increased with Increasing temperature. Most toxic effects of the polymers resulted from MCN. Descriptors: MOUSE RABBIT POLY STYRENE POLY VINYL CHLORIDE POLY URETHANE UREA RESIN WOOD TEMPERATURE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); COMPARATIVE BIOCHEM-GENL STUD IES(10O10); BIOCHEM-GASES( 10O12 ) ; BIOCHEM STUD-C.ENERAL( 10060) : M I NERALS ( 10069 ) ; EXTERN E FF-HOT ( 106 1 B ) : PATI IDLOGY-COMPARA TIVE( 12 503); PATHOLOGY -NECROSIS( 125 10): META- BOLI SM'-GENL STUD , MET AB PATHW( 13002 ) ; MINERAL S ( 13010) : RESPIRATORY SYST-GENL STUD.METHS( 1 600 1 ): RESPIRATORY SYST-PATHOLOGY (* 16006); TOXICOL-ENVIRONMNTL,INDUSTR(*22506); TEMPERATURE-GENL,METHS(23001); ENVIRON HEALTH-A IR.WATR,SL POLLNf*37015 ) ; FORESTRY ANO FOREST PRODUCTS{53500) Blosystemat1c Codes: SPERMATOPHYTA-UNSPECIFI ED(25000): L E PORI DA E{B 6040) ; MUR IDAE(86375) 71052345 CHROMOSOMAL ANALYSES IN VINYL CHLORIDE EXPOSED WORKERS RESULTS FROM ANALYSIS 18 AND 42 MONTHS AFTER AN INITIAL SAMPLING ANDERSON D; RICHARDSON C R; WEIGHT T M; PURCHASE I F H; ADAMS W G F CENT. TOXICOL. LAB., IMPERIAL CHEM. I NO. LID., ALDERLEY PARK, MACCLESFIELD. CHES. SK10 4TU, G.B. MUTAT RES 79 (2). 1980. Language: ENGLISH 151-162. Coden: MUREA In a previous study. 57 workers occupationally exposed to vinyl chloride (VC) had an Increase In the Incidence of chromosomal abnormalities In their lymphocytes as compared with 24 control workers. Since that time, threshold limit values for VC and plant exposure levels have been reduced. Two further samples from the same population of workers were analyzed for chromosomal aberrations 18 and 42 mo. after the Init1 a 1 samp ling. At 18 mo. . 21 VC workers and 6 off-site controls were Investigated as were 23 workers and 8 on-site controls at 42 mo. In the 2nd sampling, there was a tendency to an Increase In chromosoma 1 abnorma1 1 t 1 es of VC-exposed workers except In those people who had changed occupa t1 on. By the 3rd sampling, there was a decrease by comparison with previous samplingsand the levets of abnormalities had In exposure to VC Is accompanied by a reduction In the chromosomal abnormalities to levels Indistinguishable from those of cont rols. Descriptors: HUMAN LYMPHOCYTES MUTAGEN OCCUPATIONAL EXPOSURE Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(*02508); GENE TICS/CY- TOGENET-HUMAN(*03508); BIOCHEM STUO-GENERAL(10060): BIOCHEM STUD-NUCL ACD.PURNS.PYRM(10062); BLOOD/BODY FLOS-BLOOO CELL STUOS( 15004); BLOOD/BOOY FLDS-LYMPHAT TISS,RES(* 15008); TOXICOL-ENVIRONMNTL. INDUSTR{* 22506); NEOPLSMS/NEOPL AGNTS-CAR- CINOGENSf*24007); ENVI RON HEALTH-OCCUPATNL HEALTH( 370 1 3 ) Blosystemat1c Codes: H0M1NIDAE(86215) 7 104932 1 REACTIONS OF VITAMIN B-12R WITH POLY HALOGENATED HYDRO CARBON PESTICIDES LARANJEIRA M C M; ARMSTRONG 0 W; NOME F DEP. QUIM., UNIV. FEO. SANTA CATARINA. 88.000, F LOR IANOPOLIS. SC. BRAZ. BIOORG CHEM 9 (3). 1980. 313-317. Coden: BOCMB Language: ENGLISH The reaction of vitamin B12r. genera ted by photo 1ys 1 s of mo thylcoba1 am In under a N2 atmosphere, with DDT, results In extensive dechlorination and formation of DDO and ODE as the major products. Minor quantities of 1, 1-bIs(p-ch1oropheny1 )-2 - -chioroe thane (00MS), 1,l-b1s(p-chloropheny1)- 2-ch1oroethyIene (00MU), 1 , 1-b 1 s{p-ch1oropheny1 )e thane (DOO) and 1 , t-b1s(p- chi - oropheny1)ethy 1ene (ODNU) were also formed. Reaction of vitamin B12r, with DOD results In the production of ODMU and DDMS, the latter of which can react to produce ODNU and DDO. ODE and DDMU do not react with vitamin B12r. The results obtained are suggestive of a vitamin B12r-mod 1 ated dech1 or Ina t1 on pa thway for po1yha1ogenated hydrocarbon pes tIc1des. Descriptors: DDT DDE DDD 1 1 BIS-P CHLOROPHENYL-2-CHLORO ETHANE 1 1 SIS-P CHLOROPHENYL-2-CHLORO ETHYLENE 1 1 BIS-P CHLOROPHENYL ETHANE t 1 BIS-P CHLOROPHENYL ETHYLENE DECHLORINATION PAHIWAY Concept Codes: COMPARATIVE BIOCHEM-GENL STUDIES!IOOIO): BIOCHEM STUO-GENERAL( 10060): METABOLISM-GENL S TUO,MF T AB PATHW( 13002); TOXICOL-GENL/EXP STUDS.METHS(* 22501); TOXICOL-E- NVIRONMNTL.I NOUSTR(22506): ENVI RON HEALTH-A IR.WAIR.SL P0LLN(3- 7015); PEST CONTRL GENL/PESTICS/HERBICS(*54600): ECONOM ENIOMOL - CHEM PIIYS CONTRL ( 600 1 6 ) Blosystcmnt1c Codes: ABSTRACTS DF ENTOMOLOGY(96000) I DI ALO 1e5: BIOSIS Previews 77-83/Jan BA75Q2;RRM2402(See FI R&S A 38402 201 of 858) User 3614 25JaHB3 204 8 71042988 EFFECT OF PLASTIC CONTAINERS ON LIQUID PRESERVATION OF HUMAN GRANULOCYTES t. WITH AND WITHOUT DNASE AND HYDROCORTISONE CONTRERAS T d: JEMIONEK d F; FRENCH U E: SHIELDS L d OEP. EXP. HEMATOL.. ARMEO FORCES RAOIOBIOL. RES. BETHESDA. MD. 20014. USA. INST.. TRANSFUSION {PHI LA) 20 (5). 1980. 519-530. Coden: TRANA Language: ENGLISH The effects of 4 types of plastic polymer containers (polyvinyl chloride (PL-146), b1 or 1ented-btox I a 1 polyolefin, ethy1ene-v1ny1 acetate and polypropylene) on the In vitro recovery. viability. membrane 1ntegrity and phagocytosIs of human granulocytes (PMNL; polymorphonuclear leukocytes) were studied. Cells were collected by cont1nuous-f1ow centrifugation 1eukapheres1s (CFCL), then further Isolated by counterflow centr1fugatlon-e1utrI at1 on (CCE), and stored at 4-6.degree. C for up to 14 days at concentration of 6 .times. 106 PMNL/ral In medium with or without hydrocortisone (HC) or DNase. Regardless of the containers, there were no significant differences observed in the responses of PMNL within the first 48 h of storage. PMNL stored In the polyvinyl chloride (PL-146) containers with or without HC and DNase maintained a significantly higher viability and slower moan cell volume (MCV) expansion rate after 48-96 h compared with that stored in other containers. The phagocytic response was comparable In surviving PMNL from all containers during the first 7 days. Addition of HC and DNase to the storage medium reduced the rate of PMNL volume expansion In all containers, Improved the viability In all but the polypropylene containers. but had no effect on the phagocytic response. Since the results show a strong correlation between the rate of PMNL volume expansion during storage and subsequent loss of PMNL viability and function. the containers made with PL-146 polyvinyl chloride are superior to those made of b1 or 1ented-btax 1 a 1 polyolefin, ethy1ene-vIny1 acetate or polypropylene. Descriptors: POLYMORPHONUCLEAR LEUKOCYTE IN-VITRO RECOVERY VIABILITY MEMBRANE INTEGRITY PHAGOCYTOSIS MEAN CELL VOLUME EXPANSION RATE POLY VINYL CHLORIDE BI ORIENTED BI AXIAL POLY OLEFIN ETHYLENE VINYL ACETATE POLY PROPYLENE LOW TEMPERATURE STORAGE CONDITIONS Concept Codes: GENERAL LABORATORY APPARATUS(*01006); MICROSCOPY-CYTOLOG,CYTOCHEM TECH(01054); CYT0LOGY/CYTOCHEM-HU- MAN(02508); MATHEMATIC BIOL/STATISTIC ME7H(04500): BIOCHEM STUD-GENRAL( (0060) : BIOCHEM STUO-PROTEINS.PEPTIDES.AMI NO AC0{10064); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-MEMB- RANE PHENOMENA(*1050B); EXTERN EFF-COLD(10616); ENZYMES-METHO- 0S( 10804); ENZYMES-PHYSI 0LOGICAL STUDIES(10808); MOVEMENT(12- lOO): PATHOLOGY-NECROSISt12510): METABOLISM-PROTNS.PEPTDS.AM ACOS( 13012); BLOOD/BOOY FLOS-GENL STUDS.METHS(* 15001): BLOOO/BODY FLDS-BLOOD CELL STUDSf* 15004 ) ; BLOOD/BODY FLDS-LYMPHAT TISS,RES( * 15008); ENDOCRINE SYST-ADRENALS( * 17004 ) ; PHARMACOL-DRUG METAB,METAS STIMU(22003); PHARMACOL-CL 1NICAL PHARMACOL(22005); PHARMACOL-ENDOCRINE SYST(22016); TOXICOL-Gf- NL/EXP STUDS.METHS(22501); TEMPERATURE-GENL,METHS(23001): TEMPERATURE-CRYOBIOLOGY(23004) ; TEMPERATURE-HYPO,HYPERTHERMI A(23006}: IN VITRO STUDS-CELLULR,SUBCEl. L ( *32600) Blosysterna11 c Codes: HOMINIDAE(86215) 71042263 DETERMINATION OF RESIDUAL VINYL CHLORIDE IN POLY VINYL CHLORIDE RESINS LAZARIS A YA; SCHMUJLOVICH S M: KALMIKOVA T A V.A. KARGIN INST. POLYMER CHEM. TECHNOL.. DZERJINSK. GORKY DISTRICT 606000. d CHROMATOGR 198 (3). 1980. 337-346. Coden: dOCRA Language: ENGLISH The determination of residual vinyl chloride (VC) In poly(vinyl chloride) (PVC) powders based on thermal desorbtion In a carrier gas stream and trapping of the VC Is described. A trap is Installed In the heated Injection port of a gas chromatograph and desorbed volatiles are chromatographed by a 2-stage chromatographic system. While VC Is purged through an analytical volumn. the first column is cleaned by back -f1ush1ng. The me thod was tested on various types of PVC powders and has no limit of sensitivity. Descriptors: CHROMATOGRAPHY SENSITIVITY LIMIT Concept Codes: GENERAL LABORATORY METHOOS(01004 ) ; COMPARATIVE B10CHEM-GENL STUDIES(10010); BIOCHEM METH-GENERAL- (*10050); BIOCHEM STUD-GENERAL( 10060); BI0PHYS-GENERAL BIOPHYS TECH(* 10504) ; BIOPHYS-MOLECUL PROP.MACROMOLEC( 10506 ) ; EXTERN EFF-HOTt10618); MOVEMENT{12100): TOXICOL-GENL/EXP STUDS.METHS- (22501); T E MP ERA TUR E-GENL,ME Tl IS(23001); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); PUB HEALTH-LAB METHS(37006) mDIALOG 1 e5 : BIOSIS Previews 77-83/Jan BA7502 RRM2402( See F I 1 e55 ) (c. BIOSIL R&S 138403 58) User 3614 25Jan83 2049 71041645 ADSORPTION CAPACITIES OF ACTIVE CARBON TUBES FOR SAMPLING ATMOSPHERIC VINYL CHLORIDE VAPOR MATSUMURA Y NATIONAL INST. INDUSTRIAL HEALTH. 21-1, NAGAO. 6-CHOME, TAMA-KU. KAWASAKI 213. JPN. IND HEALTH 18 (2). 1980. 61-68. Codeh: INHEA Language: ENGL ISH Adsorption capacities of sampling tubes packed with various kinds of active carbons for collecting vinyl chloride vapor were measured. Among the active carbons with Identlea) particle size. those made from coconut shell and wood were more effective than those from petroleum pitch giving longer breakthrough times. The tubes packed with active carbons of smaller particle sizes adsorbed vinyl chloride vapor for longer periods than those with larger particle sizes. The breakthrough time in adsorbing vinyl chloride flow using active carbon tubes containing S50 mg carbon of a definite type in a glass tube of 4 mm inside diameter varied depend 1ng on the sampling conditions, l.e., the active carbon tube adsorbed the vapor for a longer period when the sampling rate was slower and the humidity In the flow was low. Descriptors: COCONUT SHELL WOOD PETROLEUM PITCH Concept Codes: ECOLOGY-BIOCUMATOL,BIOMETEOROL(*07504); BI0CHEM-GASES( 10012); B10CHEM METH-GENERAL{ 10050): BI0PHYS-G- ENERAL BIOPHYS TECH( 10504); EXTERN EFF-HUMI 0 ITY( 10620): MOVEMENT( 12100): TOXI COL-ENVIRONMNTL,INOUSTfl(22506); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-A IR.WATR.SL P0LLN(* 370 15): HORTICULT-TROP FRUIT.NUT.PLANTAT(53004); FORESTRY AND FOREST PR0DUCTS{53500) Blosystemattc PA LMAE( 25380) Codes: SPERMATOPHYTA-UNSPECIF1D(25000); 71039577 METABOLIC ACTIVATION OF VINYL CHLORIDE ANO VINYL BROMIDE BY ISOLATED HEPATOCYTES AND HEPATIC SINUSOIDAL CELLS OTTENWAELDER H; BOLT H M MED. INST. LUFTHYG. SILIKOSEFORSCH. . UNI V. . CURLITTSTR. 53, D- 4000 DUSSELDORF, FRG , J ENVIRON PATHOL TOXICOL UEPTD Language: ENGLISH 4 (1). 1980. 411-418. Coden: The f ormatI on of liver sinusoidal cell tumors a f ter exposure to vinyl chloride led to a survey of hepatocytes and sinusoidal cells Isolated from rat liver as to their ability to metabol!ca11y activate vinyl chloride and vinyl bromide. Metabol Ism. of these vinyl halides to reactive metabo1 1tes Is confined primarily to hepatocytes. This favors the theory that In the liver reactive metabolites of vinyl chloride leave the hepatocytes to act on hepatic sinusoidal cells. Descriptors: RAT CARCINOGENESIS Concept Codes: CYTOLOGY/CYTDCHEM-ANIMAL(02506); COMPARATIVE BIOCHEM-GENL STUD IES( 100 10): B10CHEM STUD- GENERAL( 10060) ; METABOLISM-GENL STUD,METAB PATHW( 13002); DIGESTIVE SYST-GENL STUOS,METHS( 14001 ); DIGESTIVE SYST-PATHOLOGY(* 14006); TOXICOL -GENL/EXP STUDS.METHSl *22501 ): TOX1COl -ENVIRONMNT I . INDI14Tff/27 - DOG ) : NEDPLSMS/NEOPL AGNTS-CARCI NOGENSI *2 4007 ); HEALTH-AIR.WATR.SL POLLN(37015) B'tosys tema t Ic Codes: MUR I DAE ( 86375 ) ENVIRON 7 1035047 LOSS OF PHTHALIC-ACID- ESTER FROM POLY VINYL CHLORIDE TUBING INTO VARIOUS FLUIDS MUELLER J S; BRADLEY R L JR OEP. FOOD SERVICE, UNIV. WISCONSIN. MADISON. WISCONSIN 53706. J FOOD PROT 43 (7). 1980. 551-554. Coden: JFPRD Language: ENGLISH Migration of phthallc acid esters (PAE) from polyvinyl chloride (Tygon) tubing, approved for use with processed milk and milk products. was measured under conditions simulating norma 1 daily use. Squares of tubing were soaking in water at 10, 44 and 72.degree. C; milk at 38.degree. C; aqueous solutions of 2 chlorinated alkaline cleaners at 62.degree. C and use dilution; and 3 sanitizers at 24.degree, C and use dilution. Each soaking solution was extracted using the AQAC [Association of Official Analytical Chemists) Method for organoch1 or 1ne pesticides and analyzed quantitatively for PAEs by GLC. Water at 72.degree. C extracted greater amounts of PAEs than water at 18 or 44.degree. C. Milk extracted the least amounts of PAEs; values were usually less than 1 ppb/day. Little ' difference was seen between the two chlorinated alkaline cleaners. Sanitizers, In general, extracted the greatest quantities of PAEs, averaging about 3 ppb/day. Leaching parents of the individual sanitizers varied. Deformation tests were made on the used squares of tubing with a penetrometer. No change wa3 found compared to samples of unused tubing (control). Indicating longer use and greater PAE loss Is necessary before tubing flexibility Is affected. Descriptors: MILK TEMPERATURE SANITIZERS LEACHING PATTERNS DEFORMATION TESTS Concept Codes: GENERAL LABORATORY METHODS(01004); COMPARATIVE BIOCHEM-GENL STUDIES( 100tO): 8 IOCHEM METH-GENERAL- (10050): BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL STUD IES( 10502): BIOPHYS-GENERAL BIOPHYS TECH{10504): BIOPHYS-MOLECUL PROP,MACROMOLEC( 10506); EXTERN EFF-PHYSI CAL.M- ECH EF FECTS{ 10612); EXTERN EFF-TEMPERATURE( 10614); EXTERN EFF-H0T( 10610); MOVEMENT( I 2tOO); FOOD TECH-DAIRY PRODUC1S( * 1 3- 518); FOOD TECH-EVALNS PHYS.CHEM PROPS(13530): FOOD TECH-PREP.PROCESSNG.STORAGE!* 13532); TOXI COL-FOOD.RES IDS.ADD1T,PRESRV(*22502); TEMPERATURE-GENL.METHS(23001): DIS1NFECTIDN,DISINFECT ANTS.STERLt39500); PEST CONTRL CENL/PES- TICS/HERBICS{54600) DI ALO ?e5: BIOSIS Previews 77-B3/Uan BA7502;RRM2402(See FI15?5) R&S 138404 206 of 858) User 3614 25janB3 2050 71032270 EXTRACELLULAR POTASSIUM ION CONCENTRATION AHO POTASSIUM ION BALANCE OF THE GASTROCNEMIUS MUSCLE OF THE DOG DURING EXERCISE HIRCHE H; SCHUMACHER E; HAGEMANN H LEHRSTUHL FUER ANGEWANDTE PHYSIOL. DER UNIV. ROBERT KOCH STR. 39. 0-5000 KOELN 41. FSG. ZU KOELN, PFLUEGERS ARCH EUR J PHYSIOL Coden: PFLAB 387 (3). 1980. 231-238. Language: ENGLISH Exercise-Induced changes of the extracellular and the venous K+ concentrations ([K+Je, [K+]ven) were measured continuously in autoperfused dog gastrocnem11 using PVC (polyvinyl chloride] liquid membrane electrodes. 02 consumption { .ovrhdot.V02), blood flow and performance of the muscles were determined. The muscles were stimulated Indirectly and Isotonic tetanic contractions (0.2 s) produced every 0.7 s for > 45 min. [K+)e started to Increase immediately after the onset of exercise and reached a maximal value of 7.4 meq/t after 4 min of exercise; thereafter It decreased. reaching 5.3 meq/1 at the end of the 12 min exercise. After 6 min of recovery. [ K-*- ] e became lower than the control level. [K+]ven reached maximal values of 5.0 meq/1 after 30 s of exercise and thereafter decreased slowly to 3.8 meq/1 at the end of exercise. A K+ gradient of up to 3 meq/1 was observed between the Interstitial space and the venous blood. About 30 s after the end of exercise, a net K+ uptake of up to 0.3 .mu.eq/mln/g was observed. The K+ loss of the muscle fibers reached maximal values of 1.5 .mu.eq/mtn/g at 1.5 min after the onset of exercise. Total K+ loss was 7*/. during 12 min of exercise and 12.571 of intracellular K+ during 45 rain of exercise. The changes of [K+]e correlated closely with performance and ,ovrhdot.V02 during exercise but not during recovery. Blood flow correlated with the changes of [ K + ] e durIng exercise and recovery. Apparently. changes of [K+]e of the working muscle might be an 1mportant factor regulatlng exercise hyperemI a. Descriptors: POLY VINYL CHLORIDE LIQUID MEMBRANE ELECTRODE AUTO PERFUSION OXYGEN CONSUMPTION BLOOD FLOW STIMULATION ISOTONIC TETANIC CONTRACTION INTERSTITIAL SPACE VENOUS BLOOD HYPEREMIA Concept Codes: BIOCHEM-GASES(10012); BIOCIIEM STUD-GENERAL(t- 0060): MINERALS!10069); 8 IOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHYS-MEMBRANE PHENOMENA(*10508>; EXTERN EFF-ELECTR,MAGNET,- GRAVITY{ 10610): PHYSIOLOGY-EXERCISE.PHYS THERAP(* 12010): MINERALSt* 13010); BL00D/B00Y FLDS-8L0QD.LYMPH STU0(* 15002); MUSCLE SYST-PHYSIOL.BI0CHEM( * 17 504) BlosystematIc Codes: CANIDAE(85765) determine the influence of the m1croerw 1ronnient of cages made o f PCV [po1yv t ny1 ch1 or I do] tiles. f1oor 1 1n1ng, 1ent ox upon thotr weight and length gain. The animals lived In the cages from birth to maturity. They were compared to those living In control cages made of wood and glass. The 1 owest weight and length values. 1ndependent1y of sex. were observed In hamsters bred In PCV cages. Similar differences were noted In cages covered with f1oor. I In1ng. espec tally within the 1st wk of life. The hamsters bred In lentex cages did not show such differences In development. Descriptors: AGE POLY VINYL CHLORIDE Concept Codes: BEHAVIOR BIOL-ANIMAL BEHAVIOR(*07003): BIOPHY S-BIOENGINE ERING( 10511); PHYSIOLOGY-COMPARATIVE( 12003): REPROOUCT SYST-GENL STUDS.METHS(16501): REPRODUCT SYST-PHYSIO- L,B10CHEM( 16504); GERONTOLOGY(24500): PEDI ATRICS(25000); DEVELOPMNTL BIOL-GEN MORPHGENSIS{*25508}; LABORATORY ANIMALS-GENL STUDS(28002) B1osystemat1c Codes: CRICETI DAE(86310) 71031948 EVALUATION. OF WEIGHT GAIN AND GROWTH OF 3 GENERATIONS OF HAMSTERS BRED IN CAGES MADE OF VARIOUS CONSTRUCTION MATERIALS GROCMOWSKI J; STANKIEWICZ O; PIAIKOWSKA E INST. PEDIATR., AKAD. MED., UL. WIELICKA 265. 30-663 KRAKOW. ZWIERZETA LAB 16 (1-2). 1979 {RECO. 1980). 39-46. Codon: ZWLAA Language: POL I SH Three gonera tIons of hamsters wore subjected to studies to DIALOG FUe5: BIOSIS Previews 77-83/dan BA7502:RRM2402(See F 71028109 RAPID ADSORPTIVE LOSS OF NITRO GLYCERIN FROM AQUEOUS SOLUTION TO PLASTIC SOKOLOSKI T D: WU C-C; BURKMAN A M DIVISION OF PHARM., COLLEGE OF PHARMACY. UNIV., COLUMBUS. OHIO 43210 USA . THE OHIO STATE ` INT J PHARM {AMST) Language: ENGLISH 6 {1). 1980. 63-86. Coden: IdPHD In short time periods the loss of nitroglycerin. used for the treatment of myocardial Infarction and In open heart surgery In man, from normal saline solutions to plastic polyvinylchloride tubing Is treated as an adsorption process. The rate of adsorption Is rapid and can be quantified as an apparent Ist-order process. The half-life of the loss at 21.degree. C Is 2.8 rain. Temperature dependence of the rate constant gives a non-linear Arrhenius dependence between 6.5 and 21.degree. C. Equilibrium amounts of n1trog 1 ycerin adsorbed at several constant bulk concentrations and 3 temperatures show a type III adsorption behavior. At reduced concentrations of 0.1-0.8, the data conform to a Pol any 1 adsorption potential theory treatment. The amount of n1trog1ycer1n adsorbed Increases as temperature I ncreases. This unusual behavior may be explained by analogy to systems where similar anomalies were reported. The theore 11ca1 approaches presented here for a practical case provide a basis for studying systems involving general adsorptive phenomena. Descriptors: HUMAN MYO CARDIAL INFARCTION OPEN HEART SURGERY TEMPERATURE POLY VINYL CHLORIDE TUBING Concept Codes: BIOCHEM METH-GENERALt10050); BIOCHEM STUO-GENERAL(*10060); MINERALS(10069); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-MOLECUL PROP,MACROMOLEC(10506); EXTERN EFF-T EMPERATURE( 10614); ANATOMY/HISTOL-SURGERY( 11105); PATHOL OGY - T HE RAP y"( 1 2 5 1 2 ) : CARDIOVASC SYST-GENL STUO S . ME THS ( 1 4 50 1 ) : CARD IOVASC SYST-HEART PATHOLOGY(* 14506): CARDIOVASC SYST-8LD VESS PATHOL( * 14508); MUSCLE SYST-PATIIOLOGY{ 17 506); PHARMACOL-GENERAL STUD1ES(*22002); PHARMACOL-DRUG META8,ME TAB S T E MU(22 003) ; PHARMACOL-CL INICAL PHARMACOL(22005); PHARMACOL - - CARDIOVASC SYST(*22010); TOXICOL-PHARMACOLOGICAL(* 2 2504 ): TEMPERATURE-GENL,METHS(23001) Biosys tcmatIc Codos: HOMINIDAE(862 15) 138405 (Item 208 of 858) User 3614 25JanB3 205 1 dynamic mixture prepared by the diffusion tube technique showed that diffusion rate obtained by tbe e1ectroba1ance was practically close to that obtained by the gas chromatography. Calculated diffusion rate was also In good coincidence with the value observed by the electrobalance. Several advantages were presented to calibrate the permeation tube and the diffusion tube by the electrobalance. Descriptors: VINYL CHLORIDE ENVIRONMENTAL ANALYSIS Concept Codes: GENERAL LABORATORY METHODS(01004); GENERAL LABORATORY APPARATUS(01006): COMPARATIVE BIOCHEM-GENL STUD IES( lOO10): 81OCHEM-GASES( 10012): 8IOCHEM METH-GENERAL{* 1- 0050): BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH(10504); MOVEMENT(12100): TOXICOL-ENVIRONMNTL,INDUSTR(*22- 506); ENVIRON HEALTH-AIR.WATR.SL POLLN(*37015) 71027428 CALIBRATION OF A PERMEATION TUBE AND A DIFFUSION TUBE WITH AN ELECTRO BALANCE SODA R NATL. INST. INO. HEALTH, 21-1 NAGAO 6 CHOME, TAMO. KAWASAKI 213. JPN. . IND HEALTH 16 (1). 1980. 41-54. Coden: INHEA Language: ENGLISH An e1ectroba1ance equipped with a hang down assembly was used to calibrate a permeation rate of vinyl chloride In a permeation tube and a diffusion rate of organic solvent In a diffusion tube [used for env1ronmonta 1 analysis]. The permeation rate obtained by the electrobalance coincided fairly with that measured by a chemical balance. Gas chromatoqraphIc analysis of oronnlc solvent vapor- In the v ujwi ( / *aJ / Jan t R&S 138406 7 102 ta t 1 COULTER COUNTER AND LIGHT TRANSMISSION STUDIES OF PLATELETS EXPOSED TO LOW TEMPERATURE ADP EDTA AND STORAGE AT 12 CELSIUS HOLME S; MURPHY S CAROE ZA FOUNO. HEMATOL. PHILADELPHIA. PA. 19107. RESEARCH. 1015 WALNUT ST., <J LAB CLIN MED 96 (3). 1980. 480-493. Language: ENGLISH Coden: ULCMA Changes In apparent platelet mean volume (V) as determined by Coulter Counter were compared with changes In tight transmission properties of platelets In plasma when the platelets were exposed to low temperature, ADP, EDTA or storage for transfusion at 22.degree. C. Two light transmission parameters were determined. One was recently described; It measures the shape change of the platelets. The other was quantitated as the average extinction (optical density) perplatelet (e). With fresh PRP from 29 normal donors a strong positive correlation (r = 0.90) was found between e and V; thus e appears to reflect the volume of the platelets. When varying degrees of shape change were produced by exposure of cttratcd PRP to low temperatures or ADP. there was a linear correlation between percent shape change and the percent Increase in V and a. A complete shape change as produced by 10 .mu.M AOP Increased e and V 19 and 24%, respectively. Spherical platelets obtained from blood ant tcoagulated with EDTA showed an Increase in V that exceeded what could be produced by shape change alone and an associated decrease In e when compared with platelets In cltrated plasma. This change progressed as hours passed after blood collection. L1ght-seatter Ing theory would predict this If cellular swelling occurs. The extinction measurements were then applied. complemented with Coulter volume determinations. to the study of platelet morphology during storage for transfusion at 22.degree. C. Platelet concentrates with high platelet counts stored in containers cons t rue ted of po1yv1ny1ch1 or 1de are exposed to hypoxic conditions which lead to accelerated glycolysis, pH fall and platelet shape change. As the platelet concentrate pll fell below 6.7. there was a progress 1ve Increase In V beyond what cou1d bo accounted for by shape change and a proportionate decrease In e. This swelling may reflect the inability of the platelets to maintain normal Intracellular volume under hypoxic stress. There 3 measurements are objective, quant Ita t1vo and comp 1ementary; they reflect platelet morphology and can be used In the study of In vitro platelet behavior. Descriptors: HUMAN MEAN VOLUME SHAPE UPTICAL DENSITY ANTICOAGULANT CITRATE TRANSFUSION POLY VINYL CHLORIDE STORAGE CONTAINER HYPOXIA GLYCOLYSIS Concept Codes: GENERAL LABORATORY APPARATUS(01006); MICROSCOPY-CYTOLOG,CYTOCHEM TECH(01054): CYT0L0GY/CY70CHEM-HU- MAN( *02508): 3 IOCHEM-GASES( 10012); BIOCHEM STUD-GENERAL{ 10060) : BIOCHEM STUD-NUCL ACD.PURNS.PYRM( 1006 2 ) ; BIOCHEM STUD-CARQOHYDR.( 10068); B1OPHYS-GENERAL BIOPHYS TECH( 10504); EXTERN EFF-C0LD(* 10616); ANATOMY/HISTOL-REGEN.TRANSPLANT( 1 1 1- 07): ANATOMY/HISTOL-MICRO.ULTRAMICRSC(i 1 108 ) ; METABOLISM-ENE- RGY,RESPIRATION( 13003); METABOLISM-CARBOHYORATCS( 13004); BLOO D/BODY FLOS-GENL STUDS,METHS(* 15001): BLOOD/BODY FLDS-BLDOD CELL STUDSC* 15004); PHARMACOL - BLOOD,HEMATO AGENTS(22008); ) (c. U1US1S 1982) (Item 210 of 858) User 3614 25j? 2052 TOXICOL-GENL/EXP STUDS.METHS(22501): TEMPERATURE-GENL.METHS(2 - 3001): TEMPERATURE - HYPO,HYPERTHERMIA( *23006); IN VIIRO STUDS-CELLULR.SUBCELL{* 32600) Blosystomat1c Codes: t IOM1NIDAE{862 1 5 ) 71020897 HEMOLYTIC PROPERTIES OF SPECIAL MATERIALS EXPOSED TO A SHEAR FLOW AND PLASMA CHANGES WITH SHEAR MONROE J M; LIdANA R C; WILLIAMS M C CHEM. ENG. DEP. , UNI V. CALIF. , BERKELEY. CALIF. 94720. USA. BIOMATER MEO DEVICES ARTIF ORGANS Coden: BMOOA 8 (2). 1980. 103-144. Language: ENGLISH Types of materials (3) of special interest to the NIH Blomaterials Program were evaluated for their tendency to Induce hemolysis when exposed to a laminar [human] blood flow between rotating parallel disks. The 3 types were as follows: TDMAC[Tr11ododocy1metliy1 ammonium ch1 or 1de]-hepar1n1 zed surfaces of po1ycarbonate (Lexan). silicone rubber and polyvinylchloride; polyacrylamide hydrogels (PAH) prepared by three different chemical processes: and fluorlnated ethy1ce11u1ose (FEC). All were compared to a polyethylene (PE) standard, to normalize data for variations In blood quality. Multiple tests. showing good reproducibI 1 1ty, demonstrated: FEC Is a very low hemolyzer. about 60% of PE: the PAH surfaces are poorer than PE. giving 120-220% of PE hemolysis depending on fabrication and shipment history; and TDMAC-heparIn I zed surfaces are highly hemolytic. In the range 160-440% of PE depending on substrate. Plastics used as substrates for the coatings cited above were also evaluated: Oelrln, Lexan. Nylon 6, propylene and a polyether urethane. Tentative explanations are advanced for homo lytic variations. In terms of surface chemistry and material Interactions with the blood. Descriptors: HUMAN TRI 1ODOOECYLMETHYL AMMONIUM CHLORIDE HEPARIN POl.Y CARBONATE SILICONE RUBBER POLY VINYL CHLORIDE POLY ACRYLAMIDE HYDRO GELS FLUORINATEO ETHYL CELLULOSE POLY ETHYLENE DELRIN LEXAN NYLON 6 PROPYLENE POLY ETHER URETHANE Concept Codes: BIOCHEM STUO-GENERAL(10060); BIOCHEM STUD-CARBOHYDR.{10068); EXTERN EFF-PHYSI CAL.MECH EFFECTS(* 106- 12): MOVEMENT(12iOO): 8LOOD/BOOY FLDS-BLOOD,LYMPH STU0(*15OO2) ; BLOOD/BODY F LDS -BLOOD CELL STUDS( * 15004); TOXI COL-GENL/EXP STUDS,METHS(*22501) B i osys t etna t 1 c Codes: HOMINIDAE ( 862 1 5 ) R&S 138407 DIALOG F 1 1 e5 : BIOSIS Prev i ews. 77-83/Jan BA7502;KHMi-.u*,___ 7 1020833 EXPERIMENTAL APPLICATION OF GAS CHROMATOGRAPHIC HEADSPACE ANALYSIS TO PRIORITY POLLUTANTS UMBREIT G R; GROB R L GREENWOOD LABORATORIES. 903 E. SQUARE. PA 19348. BALTIMORE PIKE, KENNETT U ENVIRON SCI HEALTH PART A ENVIRON SCI ENG 15 (5). 1980. 429-466. Coden: UESEO. Language; ENGLISH A general procedure for the headspace analysis of volatile organic pollutants in water Is examined in detail. Theoretical and practical considerations are discussed in depth. The experimental demonstration of tho method is applied to the analysis of .mu.g/1 concentrations of methyl chloride. ethyl chloride and vinyl chloride. Details of field samp ling, calibration. analysis, aliquot transfer and standard preparation are all addressed. Stability of prepared samples over the course of 16 days was examined. With ail data included over the course of the 16 day investigation. the standard deviation of analyses of the Individual components is approx 1ma teiy . + -. 20% of each average a t nomInal 30 .mu.g/1 Initial concentrations. Descriptors: WATER ANALYSIS METHYL CHLORIDE ETHYL CHLORIDE VINYL CHLORIDE Concept Codes: ECOLOGY-WATR RESRCH,FI SUERY BI0L(07517); COMPARATIVE BIOCHEM-GENL STUOIES(10010); 8I0CHEM METH-GENERAL- {*10050); BIOCHEM STUD-GENERAL( 10060): BIOPHYS-GENERAL BIOPHYS T ECH( * 10504 ) : MOVEMENT ( 12 100)-; TOX I COL -ENV I RONMNTL . INDUSTH( *2- 2506); ENVIRON HEALTH-S EWG DISP.SANITAR(*37014); ENVIRON HEALTH-AIR,WATR,SL POLLN(*37015) 71016037 EFFICACY OF PERMETHRIN EAR TAGS AGAINST FACE FLIES MUSCA-AUTUMNALIS AND HORN FLIES HAEMATOB1A-IRRITANS ON PASTURED CATTLE KNAPP F W; HERALD F DEP. ENTOMOL., UNIV. KY.. LEXINGTON, KY. 40546, USA. SOUTHWEST ENTOMOL Language: ENGL ISH 5 (3). 1980. 183-186. Coden: SENTD Two different ear tags, polyvinylchloride (PVC) and pol yuro thane (PU), both containing 5 and 10% pormothrtn. wore placed in each ear of cows and heifers. Face flies on tho cnttlo wore reduced throughout tho tost period by an average of 21 and 74% with the 5 and tO% PVC tags and 49 and 59% with the 5 and 10% PU tags, respectively. No horn files were ohsurved on any treated cattle during tho 1st 12 wk of the test per totj. Descriptors: COW HEIFER POLY VINYL CHLORIDE POLY URETHANE PERMETHRIN Concept Codes: ECOLOGY-ANIMAL(07 508); BIOCHEM STUD-GENERAL (- 10060): CHORDATE BODY RE GNS-HE AD( U304}; TOXI COL -GENL/EXP STUDS.METHS(22501); ANIMAL PRODUCTN-GENL STUDS,METHS(*26502): PEST CONTRL GENL/PESTICS/HERBICS(54600); ECONOM ENTOMOL-ANIMAL PE STS(60012): ECONOM ENTOMOL-CHEM PHYS CONTRL(GOO 16}; PARAS ITOLOGY-VE TER I NARY{*60506) (c. BIOSIS 1982) (Item 212 df 858) User 3614 25Jan83 2053 ABSTRACTS OF ENTOMOLOGY(96000) 7 10 14766 INTERACTION OF HUMAN ALPHA THROMBIN WITH ARTIFICIAL SURFACES AND REACTIVITY OF ADSORBED ALPHA THROMBIN CHUANG H Y K; MOHAMMAD S F; SHARMA N C; MASON R G DEP. PATHOL., COLL. MED., UNIV. UTAH. SALT LAKE CITY. UTAH 84132, USA. J BIOMED MATER RES 14 (4). 1980. 467-476. Coden: JBMRB Language: ENGLISH Thrombin adsorbed onto Cuprophane or polyfvinyl chloride) (PVC) was inactive with respect to amidase activity. Desorbed thrombin from these 2 artificial surfaces showed only low amidase activity. In the presence of albumin the surface-bound thrombin appeared to exhibit Increased amidase activity. This apparent activity may be due to the action of thrombin displaced from the surfaces by albumin. Thrombin bound to Cuprophane or PVC was capable of reacting with ant(thrombin III (AT III) only in the presence of heparin. AT III bound to Cuprophane or PVC was unable to react with thrombin In eIther the absence or presence of heparin. Fibrin formation on or at surfaces was demonstrated by phase contrast microscopy when Cuprophane or PVC pretreated with thrombin and carefully rinsed was Incubated in a fibrinogen solution. Tills fibrin format1 on Is time dependent and likely is the result of direct interaction of adsorbed thrombin with fibrinogen in solution. Gtass, Cuprophane and PVC pretreated with thrombin attracted more platelets than respective untreated surfaces. The enhancIng effect of adsorbed thrombin on platelet adhesion was similar to the enhancing effect of adsorbed fibrinogen. Thrombin adsorbed onto PVC and crosslinked by glutaraldeliyda trea tment was ant tgenically active with a 1251-labeled monospecific antitiiromb1n IgG produced in rabbits. No other plasma proteins adsorbed singly or from plasma or serum onto PVC reacted significantly with the anti thrombin IgG preparation. The possible significance of these observations is d1scussed. Descriptors: RABBIT CUPROPHANE POLY VINYL CHLORIDE ANT I THROMBIN III FIBRINOGEN PLATELETS HEPARIN Concept Codes: RADIATION BIOL-RADTN, ISOTOP IECII (06504); BIOCHEM STUO-GENERAL( 10060): BIOCHEM STUD-PROTEINS.PEPTI 0ES.A - MINO AC0( 10064); BIOCHEM STUD-CARBOHYDR. ( 10OG8); MINERALS(1OO- 69) ; BIOPMYS-BIOENGINEERING( + 10511); ENZYMES-ME 1 HODS( 10804 ) ; ENZYME S-CHEM, PHYSICAL S riJOI ES( * 10806 ) ; BLOOD/BODY FLOS - GENL STUDS.METHS(* 15001): BL000/80DY FLDS-BLOOD,LYMPH SIUD(* 15002 ) ; BLOOD/BCJDY FLDS -BLDOO CELL STUDS (* 1 5004 ) ; PI IARMACOL - BLOOD . I tEM- A10 AC.ENiSf 27008 ) B losystematIc Codes: LEPORIDAE(86040) DIALOG'' rle5: BIOSIS Preview r&S 138408 402(See F111 ee5^5)) (c. BIOSIS 1982) {Item 215 of 858) User 3614 25jan83 2054 71013877 THE EFFECT OF ETHYLENE OXIDE AND CHEMICAL DISINFECTANT RESIDUES UPON THE LARYNGEAL AND TRACHEAL MUCOSA OF RABBITS STAR E G; CASELITZ J; LOENING T INST. ANAESTHESIOL. , UNI VERS ITAETSKLIN. . LANGENBECKSTR. 1. D- 6 500 MAINZ. W. GER. ZENTRAL8L BAKTER10L BETRIEBSHYG PRAEV MED ZAOMD Language: GERMAN 1 170 ABT ORIG B (5-6). 1980. HYG KRANKENHAUSHYG 539-547. Coden: Residues of ethylene oxide and chemical disinfectants In anesthesia supplies can cause side effects In patients. For this reason 37 New Zealand rabbits were Intubated with po1yv1ny I chloride endo trachea 1 tubes of 3.0-3.5 mm Inner diameter. The tubes were sterilized with ethylene oxide and aerated for 24 or 48 h In room air. At this time .they still held 600 and 80 ppm ethylene oxide as determined by gas chromatography. For comparison tubes were soaked In 2% activated Cldex or 10% Gigasept and watered for 1 h In sterile water. 5 nonlntubated animal's served as controls. All rabbits were sacrificed after 48 h and larynx and trachea examined microscopically for histological changes. In all Intubated animals hyperem I a, edema forma tlon and cellular Infiltration were found. There were epithelial erosions In about 60*/.. and 4 ulcers. The findings were more pronounced In animals which had been Intubated with tubes containing 600 ppm ethylene oxide. Almost all tubes cause median leal Irritation of the respiratory tract. Additional chemical trauma is not to be expected 1f they are watered adequately after treatment with disinfecting solutions or aerated sufficiently after ethylene oxide sterilization. Descriptors: HUMAN COMPARISON CIDEX GIGASEPT POLY VINYL CHLORIDE TRAUMA EDEMA HYPEREMIA ANESTHESIA HISTOLOGY Concept Codes: MICROSCOPY-HISTOL.HISTOCHEM TECH(0105G): CYTOLOGY/CYTOCHEM-ANIMAL(02506); COMPARATIVE BIQCHEM-GENL STUDIESflOO10); BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL( 10060): BIOPHYS-GENERAL BIOPHYS TECH( 10504); EXTERN EFF-PHYS1CAL,MECH EFFECTS! 10612); ANATOMY/HISTOL-SIJRGERY(11105); ANATOMY/HISTOL-MICRO.ULTRAMICRSC(11108); MOVEMENT(- 12100) : PATHOLDGY-COMPARATIVE( 12503): PATHOLOGY-INFLAMMATN, IN FLAM 015(12508): METABOLISM-GENL STUD.MET AB PATHW(13002); BLOOD/BODY FLDS-OTHER BODY FLDS( 15010); RESPIRATORY SYST-GENL STUD,METHS{ 16001); RESPIRATORY SYST-PATHOLOGY(* 16006); NERVOUS SYST-GENL STUDS,METHS(20501): PHARMACOL-DRUG ME TAB.ME TAB S I I MU( 2 2003); PHARMACOL -NEUROPI1ARMAC0L0GY(2 2024 ); lOXICOL-GEN- L/EXP S fUDS.ME1115(*22501); IOX 1 COL-PI IARMAC01.0GICAL{* 22504 ); DISINFECT ION,DISINFECTANTS.STERL(*39500) Blosystemat1c Codes: LEPORI DAE(86040); HOMINIOAE(86215) Codon: IAOHD Language: ENGLISH The activity of mlcrosoma1 cytochrome P-450 monooxygenase and ultrastructura of the liver were studied In rats exposed dynamically to 50. 500 and 20,000 ppm of vinyl chloride (VC) (an Industrial hepatotoxln, mutagen and carcinogen) over 10 mo. After 1 and 3 mo. of exposure to 500 and20.000 ppm of VC. the cytochrome P-450 level was slightly 1ower than In the control animals and upon continuation of exposure It was restored to the original level accompanied by a slight Increase of aniline p-hydroxy1ase activity. Liver enlargement, developed In the course of the exposure. was accompanied by u1trastruetura1 alterations beginning In the 3rd mo. of exposure to all VC concentratIons. Development of hepatic alterations (hypertrophy of smooth and rough endoplasmic reticulum, swelling of m1tochondr1 a, accumulation of lipid droplets, focal cytoplasmic degradation) Is discussed wtttV regard to the activity of microsomal monooxygenase system In metabolizing VC to toxic metabolites. Descriptors: HEPATD TOXIN MUTAGEN CARCINOGEN CYTOCHROME P-450 MONO OXYGENASE ANILINE P HYDROXYLASE Concept Codes: MICROSCOPY-CYTOLOG.CYTOCHEM TECH(0 1054 ) ; ELECTRON MICROSCOPY(01058): CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENETICS/CYTOGENET-ANIMAL(*03506): BIOCHEM STUO-GENERAL(10060) I BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(10064); BIOCHEM STUD-LIPIDS( 10066): BIOPHYS-MEMBRANE PHENOMENA( 10508 ) ; ENZYMES-GEN,COMPAR STUD.COENZYMS(10802): ENZYMES-METHODS< 1080- 4); ENZYMES-PHYSIOLOGICAL STUD IES{*10B08}; ANATOMY/HI STOL-MIC RO . ULTRAM1 CRSC (* 1 1 108 ) : METABOLISM-GENL STUD,METAB PATHW(1300- 2); METABOLISM-LIPIDS(13006): METABOLISM-PROTNS.PEPTDS.AM ACDS( 13012); DIGESTIVE SYST-GENL STUDS,METHS( 14001 ): DIGESTIVE SYST-ANATOMY( 14002); DIGESTIVE SYST-PATHOLOGY( 14006) ; TOX I COL -ENVIRONMNT L, INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-CAR- CINOGENS( *24007 ); ENVIRON HEALTH-OCCUPATNL ENVIRON HEALTH-A[R.WATR.SL P0LLN(37Ot5) HEALTH(370 1 3 ) ; B1osystemat1c Codes: MUR I DAE(86375 ) 7 10 13B3 1 MONO OXYGENASE ACTIVITY AND ULTRASTRUCTURAL CHANGES OF LIVER IN THE COURSE OF CHRONIC EXPOSURE OF RATS TO VINYL CHLORIDE VISNIEWSKA-KNYPL J M; KLIMCZAK d; KOLAKOWSKI d DEP. BIOCHEM., INST. OCCUP. MED., TERESY 8, 90-950 LODZ, POL . INT ARCH OCCUP ENVIRON HEALTH 46 (3). 1980. 241-249 01 ALD R&S 138409 )e5: BIOSI 7502;RRM2402(See F1le55 ) (c. BIOSIS 1982) (Item 217 of B58) User 3614 25)an83 2055 71013825 VINYL CHLORIDE DETECTION AT SUB PARTS-PER-BILLION LEVELS WITH A CHEMICALLY SENSITIZED ELECTRON CAPTURE DETECTOR GOLDAN P D; F EHSENF ELD F C; KUSTER W C: SLEVERS R E PHILLIPS M P; AERONOMY LAB., ENVIRON. RES. LAB., NATL. OCEANIC ATMOSPHERIC ADM., BOULDER. COLD. 80303. ANAL CHEM 52 (It). )980. Language: ENGLISH 1751-1754. Coden: ANCHA The sensitivity of an otherwise conventional 63NI electron capture detector to vinyl chloride was Increased by almost 103 by doping the N2 carrier gas with 10-50 ppm of N20. The vinyl chloride detection limit for a s1gna1 -to-no1se ratio of 2 using a porous silica packed column was 1 owered from 1 .times. 1013 molecules (.apprx. 1000 pg) per sample to 1.4 .times. lO10 molecules {.apprx. 1.4 pg) per sample. the latter limit correspond 1ng to a volume mixing ratio of 0.5 ppb for *a 1-standard cm3 air sample. This dramatic Improvement Is achieved by a chemical sens 1 t 1 zat1 on within the detector arising from the reaction of vinyl chloride with 0- formed by the reaction of N20 with thermal electrons at 350.degree. C. By the use of this technique, vinyl chloride can be easily monitored In Industrial environments either by In-situ sampling or time averaged grab sampling at sub-ppb levels. Descriptors: INDUSTRIAL MONITORING Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY{05500): BIOCHEM-GASES(10012); BI0CHEM METH-GENERAL(*10050); BIOCHEM STUD-GENERAL(10060): BIOPHYS-GENERAL BIOPHYS TECH!10504); MOVEMENT{ 12100): TOXICOL-ENVIRONMNTL,INDUSTR(* 22506); ENVIRON HEALTH-OCCUPA TNL HEALTH(*37013); P0LLN(*37015 ) ENVI RON HEALTII - AIR,WATR.SL tho pH dependence of the membrane potential. Increasing the externa) [K+) did not affect the pH dependence. CN- partially depolarized the membrane. A parallel conductance model for membrane potential could explain the results qualitatively. Concept Codes: BIOCHEM STUD-GENERAL(10060): MINERALS(10069); BIOPHYS-GENERAL STUD IES( 10502); BIOPHYS-GENERAL BIOPHYS TECH{ 10504); BIDPHYS-MEMBRANE PHENOMENA(10508>; BIOPHYS-BI DE MERGE! I CS{ * 105 lO ) ; METABOLISM-ENERGY.RESPIRATION(13003); BAC TERIA - MORPHOLOGY .CYT0L0GY(30500); BACTERIA-PHYSIOLOGY.BIOCHEMISTRY(*31000); MICROBIOLOG APPARAT- .METHS.MEDlAt 32000) B losystemat1c Codes: BACILLACEAE(056lO) 7 10 12480' CONTROL OF MEMBRANE POTENTIAL BY EXTERNAL HYDROGEN ION CONCENTRATION IN BACILLUS-SUBTILIS AS DETERMINED BY AN ION SELECTIVE ELECTRODE/ HOSQI S; MOCHIZUKI N; HAYASHI S: KASAI M OEP. BIOPHYS. ENG., FAC. ENG. SCI.. OSAKA UNIV.. TOYONAKA. OSAKA 560. JPN, BIOCHIM BIOPHYS ACTA BBACA 600 (3). I9S0. B44-852. Coden: Language; ENGLISH The membrane potential of Intact bacteria was monitored by measuring tho totraphcny1phosphonIum Ion distribution across the membrane using po1y-(v1ny1 chloride) matrix-type electrode selective to te traphenyIphosphon1um Ion. The te t raphenyIphosp- honium ion was not counter-transported against H+ movement. The membra*w* potential of 8. subtil Is was estimated to be 80-120 mV Ins Ide-negat1ve at external pH 7.' . The effect of the external pH on the membrane potential was studied. It varied from 30-40 mV/decade change in the externa! [11+} in the pH region of greater than 6.5, Increasing pH making It more 1 ns 1de-negat1ve. The addition of carbonyl . cyanide m-chlorophenylhydrazone depolarized the membrane. and the membrane potential approached the 11+ equilibrium potential. The addition of N.N'- d1 eye 1ohexy!carbodI Im1de did not abolish DIALOG R&S 138410 17-83/Jan BA7502:HRM2402{See Flle55) (c. BIOSIS 1982} (Item 219 of 858) User 3614 25Jan83 2056 71011323 IN-VITRO ACTIVATION OF 1 2 01 CHLORO ETHANE BY MICROSOMAL AND CYTOSOLIC ENZYMES GUENGERICH F P; CRAWFORD W M JR; DOMORADZKI J Y; MACDONALD 7 L; WATANABE P G DEP. BIOCHEMISTRY AND CENTER IN ENVIRONMENTAL TOXICOLOGY. VANDERBILT UNI V. SCH. MED. . NASHVILl. E, TENNESSEE 37 2 32. TOXICOL APPL PHARMACOL TXAPA 55 (2). 1980. 303-317. Coden: Language: ENGLISH [ 1,2 - 1 4C ] ) ,2-DIch1oroethane [a tumorlgonlc industrial chemical ] was metabol ized by rat 1 Sver enzyme systems to nonvolatile products and to products Irreversibly bound to protein and calf thymus DNA. Cytosolic metabolism to all 3 types of metabolites was dependent upon the presence of reduced glutathione (GSH), suggesting the role of GSH transferases. Microsomal metabolIsm to alI 3 types of products occurred via mixed function oxidation; microsomal GSH transferase(s) catalyzed the formation of metabolites irreversibly bound to ONA.' GSH blocked microsomal mixed function ' oxidase (MFO)-cata 1yzed binding to protein but stimulated binding to ONA in a synergistic manner. 2-Ch1oroaceta 1dehyde. S-(2-ch1oroethyt)-GSH and 1-chloroso-2-- ch1oroe thane are proposed as major species 1nvolved 1n Irreversible binding but vinyl chloride, 2-ch1oroethano1 and chloroethy! radicals are not. The microsomal MFO. synergistic microsomal MFO-GSH transferase and cytsolSc GSH transferase systems differed In their preferences for Irreversible blnd1ng of label from dI chioroethane to various homopo1yr1bonuc1eotfd- os and only the latter system produced metabolites mutagenic to Salmonella typhlmurium TA 1535, Several 1,2-dI chioroethane actIvatIon pathways are operative which produce dlfferent adducts; the relative contribution of each pathway to total nonvolatile metabolites. mutagenic metabolites and DNA and protein adducts under these In vitro assay conditions was es tIma ted. Descriptors: SALMONELLA-TVPHI MURIUM RAT 2 CHLORO ACETALDEHYDE S-2 CHLOROETHYL GLUTATHIONE 1 CHL0R0S0-2-CNL0R0 ETHANE MUTAGEN TUMDRIGEN GLUTATHIONE TRANSFERASES CALF THYMUS DNA Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENET ICS/CY - TOGENET-ANIMAL! *03506}; COMPARATIVE BIOCHEM-GENL STUD IES( 10O 1- O); BIOCHEM STUD-GENERAL( 10060); BIQCHEM STUO-NUCL ACD,PURNS,PYRM( 10062); BIOCHEM STUO-PROTEI NS.PEPTIDES.AM I NO ACO ( 1006*1 ) ; REPL ICATN. TRANSCRIPTN, TRANSLATE 10300) ; B I0PHYS-M- OLECUL PROP,MACR0M0LEC( 10506); BIOPHYS-MEMBRANE PHENOMENA( 105 - 08); ENZYMES-ME THODS( 10804); ENZYMES-PHYSIOLOGICAL STUDIES<*1- 0808); METABOLISM-GENL STUD,ME T AB PATHW( 13002); METABOLISM-P R - OTNS,PEPTOS,AM ACDS< 130 12); METABOLISM-NUCL ACD,PUR I NS.PYRIM( - t 30 14); DIGESTIVE SYST-GENL STUDS.METHS( 14001); OIGESTIVE SYST-PATIIOLOGY(*14006); BLOOD/BODY F LOS -LYMPHA I TISS.RES(1500- a); ENDOCRINE SYST-THYMUS(17016); TOX I COL-GENL/EXP STUDS.METHS( *2250 1); TOXI COL -ENVIRONMNTL.INDUS fR{22506); NEOP- LSMS/NEOPL AGN TS-CARCINOGENS(* 24 007}; BACTERIAL AND VIRAL GENETICS(315 00); MICROSIOLOG APPARAT.METHS.MED IA(32000); IN VITRO STUDS-CELLVJLR,SUBCE LL(32600); ENVI RON HEALTH-A IR.WATR,SL POL L N(370151 [I ln^u*l ) nma r I r* 1FMT conn ArTcnt *rr nr / nun o'v . J M *> a |* # * r. . 15 ) ; MURIDAE(8G375 > 138411 rfs /y-a:i/onn UA 7602 ; RRM2402 ( Son FIloSS) {c. RIOS IS 1982) (Item 220 of 058) User 3614 25Jjuj|i3 2057 7 1007659 HUMAN RED BLOOD CELLS WITH NORMAL OR IMPROVED OXYGEN TRANSPORT FUNCTION PREPARED AND FROZEN IN THE PRIMARY POLY VINYL CHLORIDE PLASTIC BLOOD COLLECTION CONTAINER VALERI C R; VALERI D A; DENNIS R C; VECCHIONE J d; EMERSON C P NAV. BLOOD RES. LAB., BOSTON UNIV. SCH. MED., 615 ALBANY ST., BOSTON, MASS. 0211B. USA. REV FR TRANSFUS IMMUNO-HEMATOL 467-486. Coden: RFTID 22 (5). 1979 {RECD. 1980>. Language: ENGLISH This Is a report of a new system for freezing human red blood cells [RBC] In the same polyvinyl chloride plastic container In which the blood Is collected and separated Into components. This polyvinyl chloride plastic collection bag with Integrally attached transfer packs for blood collection, component separation RBC b tochemleal mod 1f tea t ton, freezing, storage and post-thaw dilution before washing, represents a major advancement In the freeze-preservatlon process. The label with the donor's blood type and tdenttf1catI on number affixed to the bag at the time of collection remains In place throughout the freezing and thawing process. The transfused RBC are of superior quality, and the processing cost is less than with other methods of freeze-preservat1 on. There Is a lower risk of contamination with these RBC because manipulation of the product Is kept at a minimum. Rejuvenation a bioengineering process by which outdated RBC can be salvaged, can be Incorporated Into the preservation process using one of the attached transfer packs of the primary collection bag. This process has been Introduced as a possible means of alleviating the dramatic blood shortages which occur periodically. RBC may also be rejuvenated after storage In the liquid state to Increase .their 2,3 DPG [d iphosphogl ycerate] and ATP levels to 150-20054 of norma 1 , and these RBC with Improved 02 transport function were administered to anemic patients w.lth and without cardiopulmonary Insufficiency, patients undergoing cardiopulmonary bypass and treatment with hypothermia during cardiac surgery and In Instances where nonhemolytic transfusion reactions might be expected. Oescrt p tors: STORAGE TRANSFUSED BLOOD CELLS COST CONTAMINATION RISK REJUVENATION 2 3 01 PllOSPItO GLYCERATE ATP ANEMIA CARDIO PULMONARY INSUFFICIENCY CARD 1D PULMONARY BYPASS HYPO TUERMIA REACT IONS CARDIAC SURGERY NONHEMOLYTIC TRANSFUSION Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(02508}: B I OCHEM-C.ASE - S(*10012): BIOCHEM STUD-GENERAL(10060); BIOCIIEM STUD-NUCL ACD.PURNS.PYRMt 10062): BIOPHYS-B10ENGINEERING( 1051 1); EXTERN EFF-COLD( 106 16); ANATOMY/HISTOL- SURGERY(11105); PATHOLOGY - THE - RAPY( 12512); CARDIOVA SC SYST-HEART PATHOLOGY( 14506): BLOOD/BODY FLDS-GENL STUDS.METHS(* 15001); BLOOD/SODY FLDS-BLOOD.LYMPH STUD{15002); BLOOD/BODY FLDS-BLOOD CELL STUDSt* 15004); BLOOD/BOOY FLOS-BLD,LYM.RES PATH{ 15006): RESPIRATORY SYST-PATHOLOGY( 16006); TEMPERATURE-CRYOB IOLOGY(23 - 004) ; TEMPERATURE-HYPO,HYPERTHERMI A(23006); IMMUNOL/IMMUNOCHE - M-IMMUNOHEMATOLt 34 506) BlosystematIc Codes: HOMINIOAEC86215) 71002319 FATE OF SALMONELLA-INFANTIS STAPHYLOCOCCUS-AUREUS AND HAFNIA-ALVEI IN VACUUM PACKAGED BEEF PLATE PIECES DURING REFRIGERATED STORAGE KENNEDY J E UR; OBLINGER J L; WEST R L FOOD SCI. HUM. NUTR. DEP., IFAS. UNIV. FLA., GAINESVILLE. FLA. 32611. USA. J FOOD SCI 45 (5). 1980. 1273-1277, 1300. Coden: JFDSA Language: ENGLISH The fate of S. Infantls, S. aureus and H. alvei Inoculated onto vacuum packaged and polyvinylchloride {PVC) packaged fresh beef plate pieces after O. 3. 7, 14. 21 and 28 days of storage at 1.7.degree. C was Investigated. Aerobic plate counts (APC) of representative beef pieces were also monitored during storage and the effect of heat shrinking on both Inocu1 a and APC In vacuum packaged samples determined. APC of vacuum packaged beef pieces Increased slower and attained lower final numbers than did PVC wrapped pieces. Levels of S. Infantls In PVC and vacuum packaged samples declined at similar rates during 28 days of storage with overall decreases of 52 and 5554, respectively. The most rapid decreases occurred during the 1st wk of storage. S. aureus levels In PVC and vacuum packaged samples declined at simitar rates during 28 days of storage with over a 1 1 decreases of 90 and 8054, respectively. H. alvei Increased In numbers by approximately 4.45 and 4.60 log cycles/g In vacuum and PVC packaged beef pieces, respectively. during 28 days of storage. Levels of 1nocula In vacuum packaged samples were significantly 1ower Initially and during storage than respective tnocula In PVC packaged samples. Heat shrinkage of vacuum packages had no significant effect on levels of tnocula or subsequent APC. Descriptors: POLY VINYL CHLORIDE AEROBIC PLATE COUNTS HEAT SHRINKAGE Concept Codes: BIOCHEM-GASES(10012); BIOCHEM STUD-GENERAL( l- 0060): EXTERN EFF-PRESSURE{10606); EXTERN EFF-TEMPERATURE( 106- 14 ) ; EXTERN EFF-C0L0(* 106 16); EXTERN EFF-HOT{ 106 18 ) ; METABOLISM-ENERGY,RESPIRATI0N{ 13003); FOOD TECH-MEAT.MEAF BY-PRODUCTSt* 135 16 ) ; FOOD TECH-EVALNS PHYS.CHEM PROPS(* 13530); FOOD TECH-PREP,PROCESSNG,STORAGE(* 1353 2); TEMPERATURE-GENL.ME - THS{23001); TEMPERATURE-CRYOBIOLOGY(23004); BACTERIA-PHYSIOLO GY , B I OCHEM 1 STRY { 3 1000): MICROBIOLOG APPARAT.MEII IS,MED IA(3 2000) ; MED/CLIN MICROBIOL-GEN.METH.T ECH(36001 ); MEO/CLIN MICROBIOL-BACTERIOLOGY(*36002); PUB HEALTH-LAB METHS(37006); PUB HEALTH-INANIMATE DIS VECTORS(37060 ) ; PUB HEALTH MICROBIOL! 37400); FOOO/INOUS MICRO-FD/BEV SP CNTAM( 39002 ) B losys toina t Ic Corios : B AC T E R I A - UNSPE C I F I EO (04000 ) ; ENTEROOAC- TER1 ACE A E(04 010); MICROCOCCACEAH(05510); BOV I DAE(857 15 ) mDIALOG e5 : BIOS I: R&S 138412 '502;RRM2402(See F11e55) (c. B1QSIS 1982) (Item 222 of 858) User 3614 25Jan83 205 8 71002239 PREPARATION AND PROPERTIES OF BETA GLUCURONIDASE EC-3.2.1.31 IMMOBILIZED ON A POLY VINYL CHLORIDE MEMBRANE HIROSE S: HAYASHI M; TAMURA N: KARUBE I; SUZUKI S CENT. RES. LAB.. MITSUBISHI PETROCHEM. CO. LTD.. AMI, I NASHIKI , 18A RAGI 300*03, JPN. 0 MOL CATAL 9 (1). 1980. 115-124. Coden: JMCAD Language: ENGLISH .beta.-Glucuronidase [from bovine liver. EC 3.2.1.31) was Immobilized on various carriers. .beta.-Glucuronidase Immobilized on a polyvinylchloride (PVC) membrane showed the highest activity (300 mU/g wet carrier). Then .beta.-glucuronidase was Immobilized on various PVC membranes. The highest activity was observed when .beta.-glucuron1dase was immobilized on a swollen PVC membrane. The membrane prepared from the casting solution of B% PVC was suitable for the immobilization of .beta.-glucuronidase. The activity yield of . be ta .-g 1 ucuron I dase-PVC membrane was from 30-50/1. No significant difference in pH and temperature stabilities was observed between 1 mmob 1 1 I z eJd . be ta . -g 1 ucuron idase and nat I ve .beta.-g1ucuron1dase. The .beta.-glucuron1dase-PVC membrane reta 1ned Its original activity for 2 mo. at 5.degree. C. Descriptors: BOVINE LIVER Concept Codes: BIOCHEM STUD-GENERAL(10060); 8I0CHEM STUD-PROTEINS,PEPTIDES.AMINO ACD{ 10064 ) ; BIOPHYS-BIOENGINEER I - NGt* 10511); EXTERN EFF-TEMPERATURE( 10614); ENZYMES-METHODS(* 1 - 0804); ENZYMES-CHEM.PHYSICAL STUDIES(* 10806); DIGESTIVE SYST-PHYSIOL.BIOCHEM(14004); TEMPERATURE-GENL.METHS(23001) B tosystematic Codes: BOVIDAE(B5715) 71000557 AN IN-VITRO EVALUATION OF A NEW PLASTICIZER FOR POLY VINYL CHLORIDE MEDICAL DEVICES JACOBSON M S: KEVY S V; PARKMAN R; WESOLOWSKI J S DEP. MED.. CHILD. HOSP. MED. CENT.. BOSTON. MASS.. USA. TRANSFUSION (PHILA) 20 (4). 1980. 443-447. Coden: TRANA Language: ENGLISH The rate of Hatcol-200 (H-200) leaching from polyv1ny1 chi or 1de (PVC) by serum Is t/100 that of dI - 2-ethy1hexy1 phthalate (DEHP) as determined by radioassay. There Is a proport1ona1 decrease In 1eachablllty of OEHP but not of H-200 as the plasma proteins are diluted. Saline extracts of DEHP demonstrated a low but progressive rate of leaching with an accumulation of 11 .mu.g/ml after 7 wk whereas H-200 showed only a constant residue of 0.35 .mu.g/ml. Normal human serum 1ncubated for 3 wk at 37.degree. C with PVC strips plasticized with OEHP produced significant growth-Inhlbit1 on of human diploid fibroblasts. Human serum Incubated In' an Identical manner with PVC plasticized with 11-200 for up' to 4 wk demonstrated no offect on tissue culture. 11-200 deserves further evaluation ns a replacement for DEHP In PVC biomedical devices. Descr Ip tors: HUMAN 01 Pl.OID F IBROBLAST CELL GROWTH INHIUIIION PLASMA PROTEINS SERUM 1IAIC0L 200 DI-2 EIHYLHEXYL PHTHALATE LEACHABILITY Concept CocJai: C Y T OL OGY/C Y T OCHE M - HUMAN ( 02 508 ) ; RAO I AT ION 8I0L-RADTN.ISOTOP TEC1M0G504); BIOCHEM METH-GENERAL(10050); BIOCHEM STUD-GENERAL(* 10060): BIOCHEM STUD-PROT I NS,PEPTIOES . - AMINO ACO ( 10064 ) : B I 0PI1Y S - B I OE NGI NE E R I NG ( * 105 11): METABOL I SM - - PROTNS.PEPTDS,AM ACDSI 13012): BLOOD/BOOY FLOS-GENL STUOS.METHSf 15001): BLOOO/BODY FLDS-BLOOD.LYMPH STUD( * 1 5002); BLOOD/BODY FLDS-BLD . LYM.RES PATH(15006): BONE.JNTS.FASC.CONN/- ADIP-GENL{ 18001); TOXICOL-GENL/EXP STUDS.METHS(2250 I ); DEVELOPMNTL BIOL-GEN MORPHGENSIS(25508) : TISS CULTURE-APPARAT- .METHS.MEDIA(32500): IN VITRO STUDS-CELLULR.SUBCELL(32600) Blosysternat1c Codes: HOMINIDAE(86215) 21064681 TOXICITY OF VINYL CHLORIDE IN A CHRONIC EXPERIMENT GLUSHCHENKO V I; FOMENKO V N; PAVLENKO G I; SEMILETKINA N N; GRODETSKAYA N S: PANKRATOVA G P; VORONTSOV R S: GRACHEVA K M INST. IND. HYG. OCCUP. DIS.. ACAD. MED. SCI. USSR. MOSCOW, USSR . GIG TR PROF ZABOL 0 (9). 1980 (RECD. 1981). 44-46. Coden: GTPZA Language: RUSSIAN Descriptors: NOTE RAT ARRHYTHMIA MOTOR ACTIVITY RESPIRATION RECTAL TEMPERATURE OXYGEN MEMO GLOB IN ERYTHROCYTE LEUKOCYTE RETICULOCYTE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); BEHAVIOR BIOL-ANIMAL QEHAVI OR(07003); BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACO(10064); BIOCHEM' STUO-PORPHYRNS.BILE P1GM( 10065): EXTERN EFF-TEMPERATURE{ 10614) T PATHOLOGY -COMPARAT IVE( 12 503): METABOLISM-GENL STUD.METAB PAT HW( 13002): METABOL!SM-ENERGY,RESPIRATION{ 13003); ME TABOL I S- M-PROTNS.PEPTDS.AM ACDS(* 130 1 2); METABOLISM-PORPHYRI NS,BILE PIGMN(* 13013); DIGESTIVE SYST-PATHOLOGY(*14006); CARDIOVASC SYST-HEART PATHOLOGY(14506); BLOOO/BODY FLDS-BLOOD CELL STUDS(* 15004); BL00D/80DY FLOS-8LD,LYM.RES ' PATH(* 15006); BLOOD/BOOY F LDS-L YMPHAT TISS.RES(15008); RESPIRATORY SYST-PATHOLOGY(* 16006); MUSCLE SYST -PATHOLOGY(* 17 506); NERVOUS SY S T-PA THOLOGY( *20506); TOXICOL-GENL/EXP STUDS.METHS( *22501 ): TEMPERATURE-GENL.METHS(23001); TEMPERATURE-THERMOREGULATION(*23012) 8losys temat Ic Codes: MURIOAE(8637 5 ) D I ALQj 1e5: BIOSIS Pre\ R&S 138413 RM2402(See F1 ) (c. BIOSIS 1982) (Item 225 of 858) User 3614 25j 2059 21052453 LABELING IN THE WORKPLACE AS REQUIRED BY THE OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION USA FERRANDINO D; REICH A; RYER F H OEP. LABOR. OCCUP. SAFETY HEALTH ADM.. WASHINGTON. O.C. 20210. USA. MORRIS, L. A.. M. B. MAZIS AND I. BAROFSKY (ED.). BANBURY REPORT, VOL. 6. PRODUCT LABELING AND HEALTH RISKS. XVI+328P. COLD SPRING HARBOR LABORATORY: COLD SPRING HARBOR. NEW YORK. N.Y., USA. ILLUS. ISBN 0-87969-205-7. 1981). P37-54. Coden: BANRD 0 (0). 19B0 (RECD. Language: ENGLISH Descriptors: HUMAN ASBESTOS CARCINOGEN VINYL CHLORIDE ARSENIC LEAD BENZENE COKE COTTON OUST 1 2 01 BROMO-3-CHLORO PROPANE ACRYLONITRILE Concept Codes: GENL BIOL-INST I TUT.ADM IN.LEGISLN(00508); GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00520); SOCIAL BIOL/HUMAN ECOLOGY- (05500): COMPARATIVE BIOCHEM-GENL STUOIES(10010); BIOCHEM STUD-GENERAL(10060); MINERALS(10069); PATHOLOGY-GENERAL STUDIES( 12502) : RESPIRATORY SYST-PATHOLOGY( 16006); TOXICOL-EN- V IRONMNTL,INOUSTR(* 22506): NEOPLSMS/NEOPL AGNTS-CARCINOGENS ( - 24007); PUB HEALTH-GENL.MISCELL(37001 ); ENVIRON HEALTH-OCCUPA - TNL HEALTHf -370 13) ; PLANT PHYSIOL-CHEM CONSTITUENTS(5 1 522) Biosysteinat 1c Codes: MALVACEAE(26330): HOMINI DAE(862 I 5) 21052434 DIRECT DETERMINATION OF POLLUTANTS IN AIR BY GAS CHROMATOGRAPHY HELIUM IONIZATION DETECTION BRAZELL R S: ANDRAWES F F: GIBSON E K AMERICAN CYANAMID, STAMFORD. CONNECTICUT 06904, USA. U HIGH RESOLUT CHROMATOGR CHROMATOGR COMMUN 4 (4). 1981. 188-190. Coden: HCJCD Language:'ENGL ISH Descriptors: VINYL CHLORIDE SAMPLING TECHNIQUE Concept Codes: ECOLOGY-GENL STUDIES,METHODS(07502) ; ECOLOGY-BIOCL1MAI0L.B10METE0R0L(07504); BIOCHEM-CASES(10012); BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(10060): BIOPHYS-GENERAL BIOPHYS TECH(10504): MOVEMENT(12100); TOXICOL-ENVIRONMNT L,INDUSTR(22506); ENVIRON HEALTH - A IR.WAIR,SL POLLNl*37015) Language: ENGLISH Descrtptors: HUMAN RAT MOUSE VINYL CHLORIDE LUNG LIVER OCCUPATIONAL HEALTH Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS,REVW(00520): CYTOLOGY/CYT OCHEM-HUMAN(02 508); BIOCHEM STUO-GENERAL( 10060); PATHOLOGY-COMPARATIVE{ 12503); METABOLISM-GENL STUD,ME TAB PATHWt13002); DIGESTIVE SYST-PATHOLOGY(14006); RESPIRATORY SYST- PATHOLOGY(* 16006); TOX I COL -ENVIRONMNTL.INDUSTR(*22506 ) ; NEOPLSMS/NEOPL AGNTS-CARC INOGENS(24007); ENVIRON KEALTH-OCCU- PATNL HEALTH(*37013); ENVI RON HEALTH-A IR.WATR.SL POLLN(*37015 ) ; EPIDEMIOL-ORGANIC 01S,NEOPLASMS(37054 ) Biosysteinat1c Codes: C T ENOOACT Y LI DAE(86315): MUR1DAE(86375) 2 1045864 EFFECT OF VINYL CHLORIDE ON RAT EMBRYOGENESIS SAL'NIKOVA L S; KITSOVSKAYA I A INST. IND. HYG. OCCUP. DIS.. ACAD. MEO. SCI. USSR, MOSCOW. USSR. GIG TR PROF ZABOL O (3). 1980. 46-47. Coden; GTPZA Language: RUSSIAN Descriptors: NOTE HUMAN ERYTHROCYTE URINE HIPPURIC-AC ID INHALATION MORTALITY OCCUPATI0NAL- HEALTH Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); CYTOLOGY/CY- TOCHEM-HUMAN(02508); BIOCHEM-GASES( 10012): BIOCHEM STUD-GENER- AL( 10060); BIOCHEM STUD-PROTEI NS,PEPTIDES,AMINO ACD(10064 ) ; PATHOLOGY-COMPARAT IVE(12503); PA 1HOLOGY-NECROSIS( 12510): META - SOL ISM-GENL STUO,MET AB PATHW( 13002); METABOLISM-PROTNS,PEPTOS- .AM ACDS(* 13012); 8L00D/80DY FLDS'BLOOO CELL STUDS{* 15004); BL00D/80DY FLOS-BLD.LYM.RES PATH(* 15006); URIN SYST/EXT SECR-GEN STUO,METH(15501); URIN SYST/EXT SECR-PATHOLOGY(1550- 6); RESPIRATORY SYST-GENL STUD.METHS(16001); IMMUNIZ,INFECT,THERAP(22100); ROUTES OF TOXICOL-ENVIRONMNTL,INOUSTR( *22506) : OEVELOPMNTL BIOL-PATHOLO- C.ICAL( *25503) ; OEVELOPMNTL B I OL - E XPER 1 MENTAL (* 25504 ) ; OEVELOP MNTL BIOL- GEN MORPHGENSIS{*25508); ENVIRON HEALTH-OCCUPATNL HrALTHt *3701 3 ) ; ENV I RON HE A l.T It-A I R , W A T R . SL POL t N ( * 370 I 5 ) BfosystematIc Codes: HOMINIDAE(862 1 5); MUR I DAE(86375 ) 21049227 EVIDENCE TOR THE CARCINOGENICITY OF SELECTED HALOGENATED HYDRO CARBONS INCLUDING ETHYLENE DI CHLORIDE INFANTE P F; MARLOW P B OFFICE CARCINOGEN IDENTIFICATION CLASSIFICATION, OCCUP. SAFETY HEA1.IH ADM., US DEP. LABOR, WASHINGTON, D.C. 22010. USA . AMES. B.. P. INFANTE AND R. REITZ (ED.). BANBURY REPORT. VOL. 5. ETHYLENE DICHLORIDE: A POTENTIAL HEALTH RISK; MEETING, LLOYD HARBOR, N.Y. . USA. NOV. 14 - 17 , 1979. XI+350P. COLD SPRING HARBOR LABORATORY: COLD SPRING HARBOR. N.Y.. USA. ILLUS. ISBN 0-87969-204-9. 0 (O). 1980. P287-308. Codon: BANRD mDIALOG 1 e5: BIOSIS Previews R&s 138414 :(See FI 1e55 (c. B10SIS 1982) (Item 229 of 858) User 3614 25Jan83 2060 2 1042859 THE DANGER OF VINYL CHLORIDE MIGRATION INTO WATER AND FOOD PRODUCTS SHEFTEL' V 0 ALL-UNION RES. INST. HYG. TOXICOL. PESTIC. POLYM. PLAST., KIEV. USSR. GIG SANIT 0 (2). 1980. 63-65. Coden: GISAA Language: RUSSIAN Descriptors: REVIEW HUMAN RAT LIVESTOCK POI.Y VINYL CHLORIDE FOOD TOXICITY WATER POLLUTION PLASTICS Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); CYTOLOGY/CY- TOCHE M-HUMAN(02508 ) ; ECOLOGY -WATR RESRCH,FI SHERY BI0L{075!7): BIOCHEM STUD-GENERALt 10060): PATHOLOGY-GENERAL STUOIES( f2502); PATHOLOGY-COMPARATIVE( 12 503); META80LISM-GENL STUD.ME TAB PAT HW( 13002): NUTRITION-PATHOGENIC D I ETS( 1 32 16 ) ; FOOD TECH-GENL STUDS,METHS(* 13502); FOOD TECH-EVALNS PHYS.CHEM PROPS( 13530) ; TOXI COL-GENL/EXP STUDS.METHS{*2 2501}; TOXICOL-F- 000.RES IDS.AODIT.PRESRV(*22502); TOXICOL-ENVIRONMNT L.INOUSTR(* 22506); TOXICOL-VETERINARY(*22508); ANIMAL PROOUCTN-FEEOS.FEEOING(265- 04): ENVIRON HEALTH-AIR.WATR,SL POLLN(*370 15) ; SCI-PATHOLOGY(*38004) VETERINARY B1osysteraat1c Codes: VERTEBRATA-UNSPECIFI ED(85150); H0M1NID- AE(862 15 ) ; MUR I DAE(86 37 5) 21042674 PRODUCTION USES AND ENVIRONMENTAL FATE OF ETHYLENE DI CHLORIDE AND ETHYLENE DI BROMIDE FISHBEIN L DEP.- HEALTH EDUC. WELFARE. FOOD DRUG ADM., NATL. CANCER TOXICOL. RES., JEFFERSON. ARKANSAS 72079, USA. AMES. B.. P. INFANTE AND R. REITZ (EO.). BANBURY REPORT. VOL. 5. ETHYLENE DICHLORIDE: A POTENTIAL HEALTH RISK; MEETING, LLOYD HARBOR, N.Y. . USA, NOV. 14- 17, 1979 . XI+350P. COLD SPRING HARBOR LABORATORY: COLD SPRING HARBOR, N.Y., USA. ILLUS. ISBN 0-87969-204-9. 8ANRD 0 (0). 1980. P227-238. Coden: Language: ENGLISH Descriptors: HUMAN VINYL CHLORIOE FUMIGANT CARCINOGENICITY OCCUPATIONAL HEALTH AIR POLLUTION WATER POLLUTION ENVIRONMENTAL TOXICITY AUTOMOBILE EXHAUST Concept Codes: GENL BIOL - SYMPOSI A.PROCDNGS.REVW(00520): CYTOLOGY/CYTOCHEM-HUMAN(02508): ECOLOGY-BIOCLIMATOL.BIOMETE0R0L(07504); ECOLOGY-WATR RESRCH,F- ISHERY BIOL(075 1 7); BIOCHEM-GASES(10012); BIOCHEM STUD-GENERAL( 10060); PATHOLOGY-COMPARATIVE{ 12 503) ; METABOLISM- -GENL STUD.METAB PATHW( 13002): TOXI COL-ENVIRONMNTL.1NDUSTR(*2 - 2506); NE OPL SMS/NEOPL AGNTS-CARC INOGENS( *24007 ); ENVIRON HEALTH-OCCURA TNL HEALTH(*37013); ENVIRON ) IEALTH-A IR.WATR.SL POLLN( * 370 15); PEST CONTRL GENL/PEST ICS/HERBICS(* 54600) Dlosystemattc Codes: HOM]NIDAE(86215) SOLVENTS INTO THE AIR FROM PAINTED AND VARNISHED SURFACES DERGACH E A; KATISHONOK L A; KHAIKINA N M LENINGR. SCI.-PROD. ASSOC. "PIGMENT-. LENINGRAD, USSR. GIG SANIT 0 (2). 1980. Language: RUSSIAN 76-77. Coden: GISAA Descriptors: NOTE HUMAN VINYL CHLORIDE ACETONE GLYCERIN AIR POLLUTION ENVIRONMENTAL TOXICITY Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(02508); EC0L0GY-BIOC- LIMATOL.BIOMETEOROLt*07504); COMPARATIVE 8 IOCHEM-GENL STUDIES- ( 10010): BIOCHEM-GASES( 10012): BIOCHEM METH-GENERAL(* 10050): BIOCHEM STUD-GENERAL( 10060); EXTERN EFF-HUM10 ITY( 10620) : PATHOLOGY-GENERAL STUD IES( 12502); METABOLISM-GENL STUD.ME TAB PATHW(13002); TOXICOL-ENVIRONMNTL.INDUSTR(*22506): ENVIRON HEALTH-OCCUPATNL HEALTH(37013): POL LN(*37015) ENVIRON HEALTH-A IR,WATR.SL Biosystematic Codes: HOMINIDAE{86215) 21042587 A STEP TOWAROS PREVENTING ACID PRECIPITATION KLEINERT J SLOVAK UNION OF NATURE AND LANDSCAPE PROTECTORS. DISTRICT COMMITTEE IN BANSKA BYSTRICA, UEBE SAV VS, CS 97602 STARE HORY, CZECHOSLOVAKIA. ENVIRON CONSERV EVCNA 7 (4). 1980 (RECD. 1981). 332. Coden: Language: ENGLISH Descriptors: NOTE PLANT ANIMAL SULFUR DI OXIDE NITROGEN DI OXIDE HYDROGEN CHLORIDE POLY VINYL CHLORIDE AIR POLLUTION ENVIRONMENTAL TOXICITY Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); ECOLOGY-8IO- CLIMATOL.BIOMETEOROLt *07504); ECOLOGY-PLANT{*07506); ECOLOGY - - ANIMAL(*07508); ECOLOGY-WATR RESRCH,FISHERY BIOL(07517): BIOCHEM-GASES(10012); BIOCHEM METH-GENERAL(10050); BIOCHEM STUO-GENERAH* 10060); PATHOLOGY-GENERAL STUD IES( 1 2502); PATHOLOGY-COMPARATIVE(12503); METABOLISM-GENL STUD.METAB PATHW(13002): TOXICOL-ENVIRONMNTL,INOUSTR(*22506}: ENVIRON HEALTH-AIR.WATR.SL POLLN(*37015); PLANT PHYSIOL-TRANSLOC.ACCU- MUL(51520); PHYTOPATHOL-NONPARASITIC DISEASE(*54512): INVERTS PHYSIOL-GENERAL STUD IES(64001) BIosystemat tc Codes: PLANTAE-UNSPECIFIED(11000); ANIMALIA-U- NSPECIF1ED{33000) 21042622 THE EFFECT OF RELATIVE HUMIDITY ON THE RFI EASE riF ORGANfC .*1 e5: DIALOG BIOSIS Previews 77-8 R&S 1384T5 F 1 1 e55) (c. BIOSIS 1982) (Item 233 of 858) User 3614 25jan83 206 1 2 10399 IB USING AN ELECTRIC VACUUM BRUSH AND A POLY VINYL CHLORIDE ADHESIVE BAND TO EXAMINE COMMON EVERYDAY OBJECTS IN CHILDRENS INSTITUTIONS FOR THE PRESENCE OF PINWORM EGGS/ BEREZANTSEV YU A; MEZHAZAKIS F I DIV. EPIDEMIOL. PARASITOL.. LENINGR. SANIT.-HYG. MED. INST., LENINGRAD, USSR. LAB DELO O (7). 1979. 438-439. Language: RUSSIAN Coden: LASDA Concept Codes: GENERAL FIELD APPARATUS(*01010); B10CHEM STUD-GENERAL(10060); PEDIATRICS{25000): DEVELOPMNTL BIOL-GENL- .DESCRIPTIVE(*25502): PUB HEALTH-HEALTH SERV.MEOL CARE(37012); PUB HEALTH-INANIMATE DIS VECTORS(*37060); PARASITOLOGY-MEDICA- L{*60504); INVERTB PHYSIOL-ASCHELMINTHES(*64016) B losysteraat Ic Codes: NEMATODA(51300): HOMINIDAE(86215) 21038496 BINDING KINETICS OF VINYL CHLORIDE AND VINYL BROMIDE AT VERY LOW DOSES BOLT H M; FILSER J G: LAIB R J; OTTENWAELOER H INST. TOXICOL. . UNI V. TUEBINGEN, WIUIELMSTR. 56, D-7400 TUEBINGEN 1. W. GER. CLEMMESEN, J. ET AL. (ED.). ARCHIVES OF TOXICOLOGY. SUPPL. 3.. QUANTITATIVE ASPECTS OF RISK ASSESSMENT IN CHEMICAL CARCINOGENESIS: SYMPOSIUM, ROME, ITALY, APRIL 3-6, 1979. VII+336P. SPRINGER-VERLAG: NEW YORK. N.Y., USA; BERLIN, WEST GERMANY. ILLUS. PAPER. ISBN 0-387-09584-5; ISBN 3-540-095B4-5. 0 (O). 1980. P 129- 142. Language: ENGLISH Coden: ARTOO Descriptors: GLUTATHIONE' RAT CARCINOGEN HEPATO CELLULAR CARCINOMA Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS,REVW(00520): BIOCKEM STUD-GENERALt 10060): BIOCHEM STUD-PROTE1 NS,PEPTIDES,A - MI NO A CD( 10064 ); METABOLISM-GENL STUD.METAB PATHW( 13002 >: DIGESTIVE SYST-PATHOLOGY< * 14006); TOXICOL-GENL/EXP STUDS.METHS( *22501): NEOPLSMS/NEOPL AGNT S - C ARC I NOC.E NS ( * 24 007 ) BlosystematIc Codes: MUR IDAE(B6 37 5) 21038487 PROCEDURES FOR ASSESSING RISK AT LOW LEVELS OF EXPOSURE CORNTIELD J: RAI K; VAN RYZIN J BIOSTAT. CENT., GEORGE WASH. UNIV., BETHESOA, MD. 20014. USA . CLEMMESEN, J. ET AL. (EO.). ARCHIVES OF TOXICOLOGY. SUPPL. 3. OUANI I.I AT IVE ASPECTS OF RISK ASSESSMENT IN CHEMICAL CARCINOGENESIS; SYMPOSIUM, ROME. ITALY, APRIL 3-6, 1979. VI I+336P . SPRINGER-VERLAG: NEW YORK, N.Y. , USA; BERLIN, WEST GERMANY. ILLUS. PAPER. ISBN 0-387-09584-5; ISBN 3-540-09584-5. 0 (0). 1980. P295-304. Coden: ARTOD Language; ENGLISH Descriptors; ANIMAL HUMAN NITRILO TRI ACE I IC-ACID VINYL CHLORIDE CARCINOGEN Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520) ; ft 1 OCUFM STIirs-OFUFRA) < 100601 TOXTCm-OFMI/FXIl 611 in 6 UCMlU 17- 501): NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007) Blosystemat Ic Codes: ANIMAL I A-UNSPECIFIEO(33000); HOMINIDAE- (86215) 2 1038484 EPIDEMIOLOGICAL ASSESSMENT AND ANIMAL DATA AS A BASIS FOR RISK PADDLE G M IMP. CHEM. IND. LTD., P.O. BOX 3. FULSHAW HALL. WILMSLOW. CHESHIRE SK9 10B. ENGL., UK. CLEMMESEN. J. ET AL. (ED.). ARCHIVES OF TOXICOLOGY, SUPPL. 3. QUANTITATIVE ASPECTS OF RISK ASSESSMENT IN CHEMICAL CARCINOGENESIS: SYMPOSIUM. ROME, ITALY. APRIL 3-6. 1979. VII+336P. SPRINGER-VERLAG: NEW YORK, N.Y., USA; BERLIN, WEST GERMANY. ILLUS. PAPER. ISBN 0-387-09584-5; ISBN 3-540-09504-5. O (0). 1980. P263-270. Language: ENGLISH Coden: ARTOD Descriptors: CARCINOGEN HUMAN ETHYLENE 01 BROMIDE VINYL CHLORIDE Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); BIOCHEM STUD-GENERAL( 10060): TOXI COL-GENL/EXP STUDS.METMS(* 22- 501); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(24007); LABORATORY ANIMALS-GENL STUDS{2B002); EPI DEMIOL-ORGANIC 0 IS.NEOPLASMS(*3 7054 ) BlosystematIc Codes: ANIMAL I A-UNSPECIFIED{33000): HOMINIDAE(86215) 210251B5 MUTAGENICITY OF GASES IN THE CHINESE HAMSTER OVARY CELL ASSAY BARSKY F C: KRAHN 0 F-; IRR J D E. I. OU PONT OE NEMOURSftCO., WILMINGTON, DEL. 19898. 10TH ANNUAL MEETING OF THE ENVIRONMENTAL MUTAGEN SOCIETY. ENVIRON MUTAGEN 1 (2). 1979 (RECD. I960). 167. Coden: ENMUO Language: ENGL ISH Descriptors: ABSTRACT SALMONELLA RAT LIVER VINYL CHLORIDE Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS,REVW(00520); CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENE TICS/CYlootNET -AN IMA L{*03506); BIOCHEM-GASES( * 10012); BIO- CtlEM STUD-GENERAL ( 10QG0); DIGESTIVE SY ST-P1IYSI OL . B I OCHEMt 1400 - 4); REPRODUCT SYST-PI IYSIOL.BIOCHEM( 16504 ) ; TOX I COL-GFNL/EXP STUDS.METIISt *22501 ) ; BACTERIAL AND VIRAL GENETICS(31500); TISS CULTURE -APPARAT.METHS,MED I A(3 2 500) BlosystematIc Codes: ENTEROBACTERI ACEAE(04810); CRICETIDAEf - 863 10): MUR I DAE(86375) DI ALOG^^l e5 : BIOSIS Previews 77-83/Ja R&S 138416 1 e55) (c. BIOSIS 1982) (Item 238 of 858) User 3614 25jan83 2062 21025171 CHROMOSOME GAPS ARE ASSOCIATEO WITH CHEMICAL MUTAGENESIS ANDERSON 0: RICHARDSON C R CENTRAL TOXICOL. CHESHIRE. U.K. LAB.. ICI, ALOERLEY PARK. MACCLESFIELO. 1OTH ANNUAL MEETING OF THE ENVIRONMENTAL MUTAGEN SOCIETY. ENVIRON MUTAGEN ENMUO 1 (2). 1979 (RECD. 1980). 179. Coden: Language: ENGLISH Descriptors: ABSTRACT RAT ETHYL METHANESULFONATE MITOMYCIN C TRI METHYL PHOSPHATE BENZENE VINYL CHLORIDE Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS,REVW(00520): CYTOLOGY/CYTOCHEM-ANIMAL{*02506); GENETICS/CYTOGENET-ANIMAL(*03506}; PHARMACOL-GENERAL STUD IES{- 22002); TOXICOL-GENL/EXP STUDS.METHS(22501); TOXICOL-PHARMAC OLOGICAL (22504); CHEMOTHERAPY-GEN STUO.METH,METAB(38502) Biosystematlc Codes: MUR I DAE(86375) 21023781 HUMAN MALFORMATIONS INDUCED BY ENVIRONMENTAL NOXAE HECKER W C: ANGERPOINTER T A KINDERCHIR. KLIN.. UNIV.-KLINDERKLIN.. OR. VON HAUNERSCHEN KINDRESP3TAL. LINDWURMSTR. 4, 8000 MUENCHEN 2. FORTSCHR MED 98 (47-48). 1980 (RECD. t9Bt). 1867-1870. Coden: FMOZA Language: GERMAN Descriptors: DRUGS THALIDOMIDE CYTOSTATIC AGENTS POLY VINYL CHLORIDE TRI CHLORO PHENOL TERATOGEN GEOGRAPHIC AREA OCCURRENCE ALCOHOLIC EMBRYOPATHY CLEFT LIP OCCUPATIONAL CONNECTIONS Concept Codes: RADIATION BIOL-RADTN EFF.PHOTECT(06506); BEHAVIOR BIOL-HUMAN BEHAVI0R(O7OO4); BIOCItEM STUD-GENERAL(100- 60): DENTAL/ORAL 8 IOL-PATHOLOGY( 19006); PSYCHI ATRY-ADD ICTION(- INC SMOKNG)(21004); PHARMACOL-GENERAL STUDIES(*22002); PHARMACOL-CLINICAL PHARMACOL(22005): TOXICOL-GENL/EXP STUDS,M- ETHS(*22501 ) ; TOXI COL-PHARMACOLOGI CAL( * 22504) ; DEVELOPMNTL BIOL-PATHOLOGICAL(*25503); DEVELOPMNTL BIOL-DESCRIP TERATOL(- 25552): ENVIRON HEALTH-OCCUPATNL HEALTH( * 37013); EPI DEMIOL-OR- GANIC 01S.NEOPLASMS( *37054) Blosystemat1c Codes: H0M1NIDAE(86215) CYT0L0GY/CYT0CHEM-ANIMAL(Q2506) ; COMPARATIVE BIOCJIEM-GE NL STUDIES( 10010) : BIOCHEM METH-NUCL ACD,PURNS.PYRM( 10052 ) ; BIOCMEM METH-PROTNS.PEPTDS.AM AC( 10054); BIOCHEM STUD-GENERAL - (10060); BIOCHEM S1UD-NUCL ACD.PURNS.PYRM{10062); BIOCHEM STUD-PROTEINS.PEPTIOES.AMINO ACD(10064); METABOL1SM-GENL STUD.ME T AB PATJIW( 13002); METABOLISM-PROTNS.PEPTDS.AM ACDS(*13- 012); METABOLISM-NUCL ACO,PUR I NS,PYRIM(* 13014>; DIGESTIVE SYST-GENL STUDS.METHSt 14001): DIGESTIVE SVST-PATHOLOGY( 14006 ) ; TOXICOL-GENL/EXP STUDS.METHS(* 22501 ); ENVIRON HEALTH-MISCELL STUDS( 370 19) Biosystematlc Codes: MURIDAE(86375 ) 2 1017881 UNCLASSIFIED DISEASES PARASITIC INFECTIONS ANCYLOSTOMIASIS OTTO G F OEP. ZOOL., UNIV. MD.. COLLEGE PARK. MD. LAST, J. M. MAXCY-RDSENAU PUBLIC HEALTH ANO PREVENTIVE MEDICINE. 11TH EDITION. XXV+1926P. APPLETON-CENTURY-CROFTS: NEW YORK, N.Y., USA. ILLUS. MAPS. ISBN 0-8385-6186-1. O (O). 1980. P478-484. 497. Coden: 09800 Language: ENGLISH Descriptors: NECATDR-AMERICANUS ANCYLOSTOMA-DUOOENALE HUMAN INTESTINAL PARASITE ANEMIA USA DIAGNOSIS EPIDEMIOLOGY SANITATION MAL NUTRITION PYRANTEL PAMOATE TETRA CHLOROETHYLENE BEPHENIUM HYDROXY NAPHTHOATE ANT I PARAS ITIC-DRUG Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(O0520 ) : BIOCHEM STUD-GENERAL( 10060): PATHOLOGY-01AGNOSTIC(* 12504 ) ; PATHOLOGY-THERAPY(12512): NUTRITION-MALNUTRITION.OBESITY(13203): DIGESTIVE SYST-PATHOLO- GY{14006); 8LOOD/BOOY FLOS-BLD.LYM,RES PATH( * 15006); PHARMACOL-CLINICAL PHARMACOL(22005); ENVIRON HEALTH-SEWG DI SP , SANI TAR( 37014 ) ; ENVIRON HE A1. TH-A I R . WA T R . S L POL LN ( 3 70 1 0 ) : EPIDEMIOL-COMMUNICABLE 01SEASES(*37052); CHEMOTHERAPY-ANT I PAR - ASITIC AGNTS< 385 10)': P AR A S I T OLOGY - ME DI CAL ( * 60504 ) ; INVER TB PHY SIOL-A SCNELM1NIHE S{*64016) Biosystematlc Codes: NEMATODA(51300): HOMINIDAE(86215 ) 21021019 ALKYLATION OF RNA BY VINYL CHLORIDE AND VINYL BROMIDE METABOLITES IN-VIVO EFFECT ON PROTEIN BIOSYNTHESIS LAIB R U; OTTENWAE LOER H; BOLT H M ABT. T OX!KOL. . PHARMAKOL. INST.. UN IV. MAINZ. D-6500 MAINZ I. JOINT MEETING OF THE'SCANDINAVIAN ANO GERMAN PHARMACOLOGICAL SOCIETIES, LUEBECK-TRAVEMUENDE, WEST GERMANY. SEPI. 16-18. 1980. NAUNYN-SCI IMIEOEBERG'S ARCH PHARMACOL 3 13 (SUPPL. ) . 1980. Rfi 3 . Corlen: NS A PC Language: ENGLISH Descriptors: ABSTRACT RAT LIVER KINETICS DNA Concept Codes : GENL B1 DI. - SYMPOS1 A , PRDCDNGS , RE VW( 00520) ; ' DIAL0^Wle5: 8I0SIS Previews 77-03/d R&S 138417 I 1 e5 5 ) (c. 8I0SIS 1982) {Item 242 of B58) User 3614 25jan83 2063 21016641 OCCUPATIONAL CARCINOGENESIS THE LOUISVILLE EXPERIENCE WITH VINYL CHLORIDE ASSOCIATED HEPATIC ANGIO SARCOMA DANNAHER C L: TAMBURRO C H; YAM L T COLUMBUS HOSP. REGIONAL ONCOL. CENTER. P.O. BOX 5013, GREAT FALLS. MT 59403. AM d MED 70 (2). 1931. 279-287. Language: ENGLISH Coden: AJMEA Descriptors: REVIEW HUMAN BIOPSY CHEMO THERAPY PROGNOSIS Concept Codes: BIOCHEM STUD-GENERAL(10060}; PATHOLOGY-0lAGN OSTIC f 1 2504): PATHOLOGY-THERAPY( 12512) : DIGESTIVE SYST-GENL STUDS.METHS(14001}; DIGESTIVE SYST-PATHOLOGY( t4006); CARDIOV- ASC SYST-BLO VESS PATHOL(* 14 508); PHARMACOL-CLINICAL PHARMACOL(22005); PHARMACOL-CARDIOVASC SYST(22010): PHARMACOL- -DIGESTIVE SY ST(2 20 1 4); TOXICOL- ENVI RONMNTL . I NDUSTR ( * 22506 ) : NEOPLSMS/NEOPL AGNTS-DIAGNS METHt*24001): NEOPLSMS/NEOPL AGNTS-CARCINOGENSI *24007 ) ; NEOPLSMS/NEOPL AGNTS* THERAP . AC.NT ( *- 24008); ENVIRON HEALTN-OCCUPATNL HEALTH!*37013); CHEMOTHERAPY- -GEN STUD.METH.METABC38502) Blosystemattc Codes: HOMINIDAE(86215) 21016017 ATTACHMENT OF VIRAL AND SPOROZOAL ANTIGENS AND ANTIBODY TO PLASTIC CARRIERS FOR ENZYME LINKED IMMUNO SORBENT ASSAY TESTS WARD L: SEVER d; SHEKARCHI I; MADDEN D NI NCOS. NIH, BETHESDA. MO. BIST ANNUAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, DALLAS. TEX., USA, MARCH 1-6. 1981. ABSTR ANNU MEET AM SOC MICROBIOL 81 (O). 1981. 286. Coden: ASMAC Language: ENGLISH Descriptors: ABSTRACT MEASLES POLY VINYL CHLORIOE POLY STYRENE Concept Codes: GENL BIOL-SYMPOSI A.PROCONGS.REVW(00520): BIOCHEM METH-GENERAL( 10050); BIOCHEM METI i-PROTNS.PEPTDS.AM AC(10054); BIOCHEM METH-CARBOHYDRATES(10058): BIOCHEM STUD-GENERAU 10060); BIOCHEM STUD-PROTEI NS.PEPTIDES,AM]NO ACO( 10064); BIOCHEM STUD - CARBOHYDR .( 10068 ) ; B I OPHYS-MOLF.CUL PROP,MACROMOLECt10506); PATHOLDGY-DIAGNOSTIC(12504); VIROLOGY- -ANIMA L HOST V I RUSES(* 33506); IMMUNOL/IMMUNOCHEM-GEN METH(34 502); IMMUNOL/IMMUNOCHEM-BACT.V IR,FUNG( *34504 } : IMMUNO LOGY - PARAS IT0L0G1CAL(*35000): MED/CLIN MlCROBIOL-V IROLOGY(* 36 - 006); MED/CLIN MICROBIOL-SERODIAGNOSIS(*36504 ) ; INVERTB PHYSIOL-PROTOZOA!*64002) Blosystemat1c Codes: ANIMAL VIRUSES-UNSPECIFI ED(02 200); PARAMYXOVIRIDAE(02228); SPOROZOA(35400) Language: ENGLISH Descriptors: ABSTRACT MAMMAL CALCIUM ION Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.R E VW(005 20); CYTOLOGY/CYTOCHEM-ANIMAL!*02506): MINERALS{ 10069); B10PHY5-GE - NERAL STUDIES! * 10502) : BIOPHYS-GENERAL BIOPHYS TECH! 10504); BIOPHYS-MEMBRANE PHENOMENA(* 10508); MINERALS(* 130 10 ) ; CAROIOV- ASC SYST-GENL STUDS.METHS(* 14501 ): CARDIOVASC SYST-PHYSI 0L.BI OCHEM (*! 4504) ; MUSCLE SYST-GENL STUDS.METHS( 1750l) Blosystemat1c Codes: MAMMALIA-UNSPECIFI ED ANO EXTINCT(85700> 21010343 ESTIMATION OF EXPOSURE TO ALKYLATING AGENTS USING GAS CHROMATOGRAPHY MASS SPECTROMETRY FARMER P 8; BAILEY E MRC TOXICOL. UNIT. CARSHALTON. SURREY. 2 1ST ANNUAL GENERAL MEETING OF THE BRITISH ASSOCIATION FOR CANCER RESEARCH. SOUTHAMPTON. ENGLAND. MARCH 31-APRIL 2, 19B0. BR d CANCER 42 (1). 1980. 193. Coden: BdCAA Language: ENGL ISH Descriptors: ABSTRACT RAT HUMAN METHYL ME THANE SULFONATE VINYL CHLORIDE HEMO GLOB IN TOXICOLOGY Concnpt Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); BIOCHEM MF.TH-GENERAL ( 10050) ; BIOCHEM S IUD-GENERAL ( 10060 ) ; BIOCHEM SIUD-PROTEINS.PEPTIDES.AMINO ACD(10064); 8I0CI1EM STUD-PORPHYRNS.B1LE PIGM( 10065); 8 IOPHYS-GENERAL BIOPHYS TECH(* 10504); BIOPHYS-MOLECUL PROP,MACROMOLEC! 10506); BLOOO/B- ODY FLOS-BLOOD CELL STUDS(* 15004): TOXI COL-GENL/EXP STUDS.METHS!*22501) B losystemat1c Codes: HOMINIDAE(86215): MURIDAE(86375 ) 2lOI1978 CALCIUM SELECTIVE MICRO ELECTRODES WITH OEVELED SU0MICRON TIPS CONTAINING POLY VINYL CHLORIDE GELLED NEUTRAL LIGAND SENSOR RINK R d: TSIEN R Y PHYSIOL. LAB., CAMBRIDGE CB2 3EG. MEETING OF THE PHYSIOLOGICAL SOCIETY, dULY 10-11. 19B0. . d PHYSIOL (LOND) 308 (0). 1980. 5P-6P: Cnrtoiv .IPHVH dialcA 1e5: BIOSIS Previews 77-83/Jan R&S 138418 ) (c. BIOSIS 1982) (Item 246 of 858) User 3614 25J 2064 21010302 SINGLE ION MONITORING OF STYRENE IN FOODS BY COUPLED MASS SPECTROMETRY AUTOMATIC HEADSPACE GAS CHROMATOGRAPHY GILBERT J; START1N J R MINI ST. AGRIC.. FISH. FOOD. FOOD SCI. DIV., HALDIN HOUSE, QUEEN ST.. NORWICH NR2 ASX. J CHROMATOGR 205 (2). 1981. 434-437. Codon: JOCRA Language: ENGLISH Descriptors: NOTE CREAM YOGHURT COTTAGE CHEESE MARGARINE CHOCOLATE SPREAO HONEY MONOMER VINYL CHLORIOE FOOD TOXICITY Concept Codes: COMPARATIVE BIOCHEM-GENL STUDIES(lOO10): BIOCHEM METH-GENERALC 10050): BIOCHEM STUD-GENERAL(10060); 8I0PHYS-GENERAL BIOPHYS TECHt10504); MOVEMENT{12100): NUTRITION-PATHOGENIC DIETS{ 13216): FOOD TECH-FATS,01LS(* 13514) i FOOD TECH-DAIRY PRODUCT S (* 1 35 1.8 ) ; FOOD T ECH-SUG AR ( * 1 3 524 ) ; FOOD TECH-EVALNS PHYS.CHEM PROPS(13530); FOOD TECH-PREP,PROCE- SSNG,STORAGE( 13532); TOXICOL - FOOD,RESIDS.ADD]T,PRESRV(*22502): ENVIRON HEALTH-MISCELL STUDS(37019); FOOD/INDUS MICRO-FD/BEV SP CNTAM(39002) ; ECONOM ENTOMOL-API CULTURE(60018) 8losystematic Codes: HYMENOPTERA{75326) 21010227 THE THERMAL DECOMPOSITION OF PHTHALIC-ACID ESTERS 20. ANALYSIS OF PHTHALIC-ACID ESTERS IN POLY VINYL CHLORIDE AND THEIR THERMAL PROPERTIES SAIDO K; MOTONASHI S; SATOMI M; KIRISAWA M OEP. PHARM., COLL. SCI. TECHNOL., NIHON UNIV.. NO. 8. 1-CHOME. KANDA-SURUGADAI, CHI YOGA, TDKYO 101, JPN. 6TH SYMPOSIUM ON ENVIRONMENTAL POLLUTANTS AND TOXICOLOGY, NAGASAKI. JAPAN. OCT. 4-5, 1979. J PHARMACOliIODYN 19 80. S - 12 , S - 28. Coden: JOPHD 3 (4). Language: ENGL ISH Descriptors: ABSTRACT FISH GAS CHROMATOGRAPHY HEAT WATER POLLUTION Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS,REVW(00520): CYTOLOGY/CYTOCHEM-ANIMAL(02506): ECOLOGY-ANIMAL(*07508); ECOL- OGY-WATR RESRCH.FISHERY BI0L{07517): COMPARATIVE BIOCHEM-GENL STUDIES( lOO10): BIOCHEM METH-GENERAL( 10050): BIOCHEM STUO-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH(10504): EXTERN EFF-HOT(10618 ) ; MOVEMENT(12lOO): METABOLISM-GENL STUD.METAB PATHW{ 13002); TOXI COL -ENVIRONMNTL, INDUSTR(*2 2506); TEMPERATURE -GENL,METHS123001); ENVIRON HEALTH-AIR,WATR.SL POLLNf*370 15); ENVI RON HEALTH-MISCELL STU0S(37019) BiosystematIc Codes: PISCES-UNSPECIFIED{85200) 21009424 INDUSTRIAL AIR POLLUTION BRITISH UK PROGRESS A REVIEW NONHEHEL G 18 DUNNINGS LANE, SOUTHAMPTON, 505 9GL. ENGLAND. ATMOS ENVIRON 15 {3). 198 1. 2 13-220. Codon: ATE NB Language: ENGL ISH Descriptors: VINYL CHLORIOE POLY CHLORINATED HI PHENYL FLUORINE TOXIC METALS RADIOACTIVE MEIALS Concept Codes:. RADIATION BIOL-HADTN EFF.PROTECT{*06506); ECOLOGY -BIOCLIMATOL,BIOMET EOROL(*07504); COMPARATIVE BIOCHEM-- GENL STUDIES(10010): BIOCHEM-GASES(1OO12); BIOCHEM STUD-GENERAL( 10060) : MINERALS( 10069); TOX I COL-ENVIRONMNTL. INO- UST R(22506); ENVI RON HEALTH-AIR.WATR.SL POLLN(* 370 15); ENVIRON HEALTH-RADIATION HEALTM{* 37017); ENVIRON HEALTH-MISCELL STUDS(37019) 21004056 ISSUES RELEVANT TO THE ASSESSMENT OF CHEMICALLY INDUCED CHROMOSOME DAMAGE IN-VIVO AND THEIR RELATIONSHIP TO CHEMICAL MUTAGENESIS ANDERSON D; RICHARDSON C R CENTRAL TOXICOLOGY LABORATORY. ICI. ALDERLEY PARK, MACCLESFIELD, CHESHIRE. UNITED KINGDOM. 9TH ANNUAL MEETING OF THE EUROPEAN ENVIRONMENTAL MUTAGEN SOCIETY, MARKASKA, YUGOSLOVIA. SEPT. 30-0CT. 5, 1979. MUTAT RES 74 (3). 1980. 223-224. Coden: MUREA Language: ENGLISH Descriptors: ABSTRACT RAT ETHYL METHANESULFONATE MITOMYCIN C TRI METHYL PHOSPHATE BENZENE VINYL CHLORIDE MUTAGENS Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520): CYT OLOGY/ CYT0C1IEM-ANI MAL ( *02506 ) ; GENETIC$/CYTOGENET-ANIMALt *03506); BIOCHEM STUD-GENERAL( lOOGO) ; PHARMACOL-GENERAL STUD IES(22002): TOXICOL-GENL/EXP STUDS.ME IMS(*22501): TOXI COL-PHARMACOLOGICAL{2 2 504 ); CHEMOTJIE- RAPY-GEN STUD,ME TH,MET AB(38502) B 1 osystematIc Codes: MURIDAE(B6375) 21003880 TESTING VINYL CHLORIDE MONOMER IN THE MAMMALIAN SPOT TEST PETER S: UNGVARY G STATE INST. HYG., LAB. HUM. GENET., BUDAPEST, HUNG. 9TH ANNUAL MEETING OF THE EUROPEAN ENVIRONMENTAL MUTAGEN SOCIETY. MARKASKA. YUGOSLOVIA, SEPT. 30-OCT. 5, 1979. MUTAT RES 74 (3). 1980. 232. Coden: MUREA Language: ENGLISH Descriptors: ABSTRACT MOUSE CYCLO PHOSPHAMIOE SOMATIC COAT COLOR MOSAICS MUTAGENS Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520): CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENETICS/CYTOGENET-ANIMAL(*03506); BIOCHEM STUD-GENERAL(10060) INTEGUMENT SYST-GENL STUDS,METHS(18501); INTEGUMENT SYST-ANATOMY(18502): PHARMACOL-GENERAL STUOIES(22002); TOXICOL-GENL/EXP STUDS.METHS( *22501 ): TOX I COL-PHARMACOLOG ICAL- (22504); NEOPLSMS/NEOPL AC.NTS - THE RAP . AGNT ( 24008 ) ; C1IEMDTHF.RAP- Y-GEN STUD.METH.METABt38502) BlosystematIc Codes: MAMMAL I A-UNSPECIFI ED AND EXTINCT(85700) ; MUR10AE(86375) DIALOG 1 e5 : BIOSIS Previews 77-83/0 R&S 738419 i 1 o55) (c. BIOSIS 1982) (Item 251 of 858) User 3614.25Jan83 2065 210037B6 METHODS FOR THE DETECTION OF MUTAGENIC GASES AND VOLATILE LIQUIDS IN THE SALMONELLA-TYPHIMURIUM MICROSOME ASSAY RUSSELL J F JR; SIPPEL M E: KRAHN D F E. I. DU PONT NEMOURS CO., WILMINGTON, DE 19898. t1TH ANNUAL MEETING OF THE ENVIRONMENTAL MUTAGEN SOCIETY, NASHVILLE, TENN., USA, MARCH 16-19, 1980. ENVIRON MUT 1980. 307. Coden: ENMUO 2 (2). Language: ENGLISH Descriptors; ABSTRACT RAT LIVER METABOLIC ACTIVATION VINYL CHLORIDE VINYLIDENE CHLORIDE METHYLENE CHLORIDE FREON 11 FREON 12 FREON 22 FLUORO CARBON 31 Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520); CYT 0 LOGY/CY TOCHEM-ANIMA L(02506); GENETICS/CYTOGENET-ANIMALf*03506); BIOCHEM-GASES(*tOO12): BIO- CHEM STUD-GENERALt10060); B10CHEM STUD-NUCL ACD.PURNS.PYRM(10* 062); METABOLISM-GENL STUD,METAB PATHW( 1 3002); METABOLISM-NUCL ACO,PUR INS,PYRIMf * (30 14>; DIGESTIVE SYST-PHYSIOL,BIOCHEM( MOO 'D; TOXICOL-GENL/EXP STUDS.METHS{*2250t); BACTER1 A - PHYSIOLOGY- . BIOCHEMISTRY(3IOOO); BACTERIAL AND VIRAL GENETICS(31500); MICROBIOLOG APPARAT.METHS.MED I A(32000) Blosys tema t1c Codes: ENTEROBACTERIACEAE(04810); MURiDAE(B6375) 2 1002823 EXTERNAL STANDPIPE DRAIN SYSTEM FOR FISH TANKS PARKER N C; JACKSON G A U,S. FISH WILDL. SERV., SOUTHEASTERN FISH CULTURAL LAB.. MARION. ALA. 36756. PROG FISH-CULT PFCUA 42 (1). 1980 (RECD. 1981). 53-54. Coden: Language; ENGLISH Descriptors; NOTE WATER LEVEL ADJUSTMENT FLUSHING PARTICULATE REMOVAL POLY VINYL CHLORIDE PIPE Concept Codes: GENERAL LABORATORY METHODS(*01004); GENERAL LABORATORY APPARATUS(*01006); ECOLOGY-AOUAT IC WILDLIFE MGMT{*07516); ECOLOGY-WATR RESRCH,FI SHERY BI0L(07517); B1OCHEM STUO-GENERAL( 10060); MOVEMENT ( 12100); CHORDATE iAXDNOMY-PISCE- S(*62510) Blosys tematIc Codes: PISCES-UNSPECIFIE0(85200) POLY CAPROAMIOE TUBE POLY UNOECAMIDE TUBE POLY ESTER ELASTOMER TUBE SILICON RUBBER TUBE POLY VINYL CHLORIDE TUBE POLY URETHANE TUBE Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520): BIOCHEM STUO-GENERAL( 10060); BIOCHEM STUD-PROTEI NS.PEPTIDES.A- MINO ACD( 10064); BIDPHYS-BI DENGINEERING(* 10511); ENZYMES-METH- ODS(* 10804); ANATOMY/HISTOL-SURGERY(* 11105); METABOLISM-PROTN- S.PEPTOS.AM ACOS( * 13012); NUTRITI ON-PROPHYLAC.THERAP DIETS(*1- 3218): DIGESTIVE SYST-GENL STUDS.METHS(14001); DIGESTIVE SYST-PATHOLDGY(* 14006); CAROIOVASC SYST-GENL STUDS.METHS(* 145- 01 ) : CARDI OVASC SYST-BLD VESS PATHOL( 14 508) ; 8LOOD/BOOY FLDS-GENL STUDS,METHS(15001): BLOOD/BODY ELDS-BLOOD,LYMPH STUD(* 15002); BLOOD/BODY FLDS-BLD,LYM,RES PATH( 15006); PHARMACOL-GENERAL STUDIES(22002); PHARMACOL-ORUG METAB.METAB STIMU(*22003): PHARMACOL-CLINICAL PHARMACOL(22005); TOXICOL-G ENL/EXP STUDS.METHS(2250I): NEOPLSMS/NEOPL AGNTS-PATH.CL IN!C{24 004 ); NEOPLSMS/NEOPL AGNTS- THERAP.AGNT(*24 008); CHEMOTHERAP Y-GEN STUD,METH.METAB(*38502> Blosys temat1c Codes: HOMINIDAE(B62 15 ) 200G4009 DEVELOPMENT OF THE POLY VINYL CHLORIDE ENDO TRACHEAL TUBE WATSON W F PORTEX LIMITED, KYTHE, KENT. BIOMATERIALS 1 (1). t980. 41-46. Coden: BIMAD Language: ENGLISH Descriptors: REVIEW HUMAN INTUBATION ANESTHESIA Concept Codes: 81OCHEM STUD-GENERAL( 10060): MINERALS( 10069); RESPIRATORY SYST-GENL STUD,METHS{* 16001 ): NERVOUS SYST-GENL STUDS.METHS(*2050i) Blosystematic Codes: HOMINIDAE(862 15) 210003 2 7 ANTI THRGMBOGENICITY OF URO KINASE IMMOBILIZED POLYMER SURFACES SUGITACHI. A; TANAKA M; KAWAHARA T; TAKAGI K DEP. SURG.. OSAKA NATL. HOSP.. OSAKA 540. JPN. 26TH MEETING OF THE AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS, INC., NEW ORLEANS, LA., USA, APRIL 17-19, 1980. TRANS AM SOC ARTIF INT ORGANS TAIOA 26 (0). 1980. 274-278. Coden: Language: ENGLISH Descr iptors: HUMAN DIGESTIVE TRACT SURGERY CARCINOMA PLASMINOGEN ACTIVATOR FIBRINOLYSIS INTRA VENOUS HYPER ALIMENTATION INTRA ARTERIAL CATHETER INFUSION OIIFMO thfdapv 01 ALO 1 1 e5 : BIOSIS Previews 77-03/Jan BA75 R&S 138420 20060577 ANIMAL MODEL OF HUMAN DISEASE HEPATIC ANGIO SARCOMA HONG C B; WINSTON J M; LEE C C LIVESTOCK DISEASE DIAGNOSTIC CENT.. UNIV. K Y,. PIKE. LEXINGTON, KY 40511. 1429 NEWTOWN AM J PATHOL AJPAA lOI (3). 1980 (RECD. 1981). 737-740. Coden: Language: ENGLISH Descriptors: MOUSE RAT VINYL CHLORIOE CARCINOGEN OCCUPATIONAL HAZARD Concept Codes: BIDCHEM STUD-GENERAL(10060): PATHOLOGY-COMPA RATIVE ( 12503); DIGESTIVE SYST-PATHOLOGY(* 14006); CAROIOVASC SYST-BLD VESS PATHOL(* 14508): TOXI COL-GENL/EXP STUDS.METHS(22- 501): TOXI COL-ENVIRONMNTL.INDUSTR(22506); NEOPLSMS/NEOPL AGNTS-PATH.CLINtC{*24004); NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(*- 24007); LABORATORY .ANIMALS-GENL STUDS(*28002): ENVIRON HE AL TH-OCCUPATNL HEALTH(37013) B1osystemat1c Codes: HOMINIDAE{86215); MUR I DAE(86375) 200585 17 EFFECT OF ACRYLONITRILE VARIOUS INFLUENCING THE MUTAGENICITY OF DUVERGER-VAN BOGAERT M; LAMBOTTE-VANOEPAER M; OE MEESTER C; PONCELET F; MERC IER M LAB. BIOTOXICOL.. 73 AV. EMM. MOUNIER. 1200 BRUSSELS. 9TH ANNUAL MEETING OF THE EUROPEAN ENVIRONMENTAL MUTAGEN SOCIETY , MARKASKA, YUGOSLOVIA. SEPT. 3O-0CT. 5. 1979. MUTAT RES 74 (3). 1980. 207. Coden: MUHEA Language: ENGLISH Descriptors: ABSTRACT SALMONELLA-TYPHI MUR IUM TA-1530 TA-1535 TA-1950 RAT LIVER MOUSE LIVER HUMAN PROPENENITRILE VINYL CHLORIDE CYANO ETHYLENE INDUSTRIAL CHEMICAL Concept Codes: GENL BIOL-S YMPOSI A,PROCDNGS.R EVW(00520); GENET ICS/CYTOGENET-ANIMAL(*03506}; GENETICS/CYTOGENET-HUMANt *03508); BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-NUCL ACD,PURNS,PYRM(10062); METABOLISM-GENL STUD,ME TAB PATHW( 13002); METABOLISM-NUCL ACD.PUR INS.PYRIM( * 13- 014); OIGESTIVE SYST-GENL STUDS.METHS{ 1400 I ): DIGESTIVE SYST-PHYSIOL.BIOCHEM(14004); TOXI COL-ENVIRONMNTL,IN0USTR{*2 2506); BACTERIA-PHYSIOLOGY.81DCHEMISTRY(31000): BACTERIAL AND VIRAL GENE 11CS(31500); MICROBIOLOG APPARAT,ME IHS.MED I A(32000): ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013) B losyr. t oma t Ic Codes: ENI EROBACTER I ACE AE ( 048 10 ) ; HOMINIDAEtB- 6215); MURIOAE(86375) (c. BIOSIS 1982) (Item 255 of 858) User 3614 25jan83 2066 Language: ENGLISH Descriptors: ABSTRACT HUMAN POLY VINYL CHLORIOE PYROLYSATE Concept Codes: GENL BIDL-SYMPOSI A.PROCDNGS.REVW(00520): BIOCHEM STUD-GENERAL(10060): EXTERN EFF-HOT( 10618 ) ; RESPIRATORY SYST-PATHOLOGY(* 16006); TOXICOL-ENVIRONMNTL.I NOUS- TR( *22506); TEMPERATURE-GENL,METHS(23001 ): IMMUNOL/IMMUNOCHEM - -IMMUNOPATHOL(*34508); ALLERGY(*35500): ENVIRON HEALTH-OCCUPA - TNL HEALTH(*37013) B (osystematIc Codes: HOMINIOAE(862 15) 20053780 OXIDATIVE AND DE TOXIFYING ABILITY OF LIVER MESENCHYMAL VS. PARENCHYMAL CELLS IN THE METABOLISM OF XENOBIOTICS DU J; TAMBURRO C H LIVER RES. LAB.. DEP. MED., UNSV. LOUISVILLE, LOUISVILLE. KY. 31ST ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER OISEASES AND THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF THE LIVER. CHICAGO. ILL.. USA, NOV. 5-10, 1980. GASTROENTEROLOGY 79 (5 PART 2). 1980. 1013. Coden: GASTA Language: ENGLISH Descriptors: ABSTRACT VINYL CHLORIOE CARCINOGEN HEPATO TOXICITY Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS.REVW{00520): CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM STUD-GENERAL(10060); METABOLISM-GENL STUD.METAB PATHW(* 13002): DIGESTIVE SYST-PHYSIOL.BIOCHEM(* 14004); DIGESTIVE SYST-PATHOLOGY(* 14006 ) ; PHARMACOL-DRUG METAB.METAB ST I MU(22003); TOXI COL-GENL/EXP STUDS.METHSt*22501 ); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(24007 ) B1osystematIc Codes: VERTEBRATA-UNSPECIFIED{85150) 2005 4 2 G9 FACTORS CONTRIBUTING TO SYMPTOMS IN MEAT WRAPPERS ASTHMA SK1RBALL D V; CHESTER E H; SCHWARTZ H J: DEAL E C; TUIHILL T M: PRESTEL T F; BARANCIK d I; 9DZ1CH T CLEVELAND, OHIO. 36TM ANNUAL MEETING OF THE AMERICAN ACADEMY DF ALLERGY. ATLANTA. GA.. USA. FEB. 16-20, 1980. J ALLERGY CLIN IMMUNOL -* i'll. 1980. 169. Coden: JACIB 138421 reviews 77 - 83/Jon BA7502 ; RRM2402 { See F11a55) (c. BIOSIS 1982) (Item 259 of 858) User 3614 25J 2067 /UU3Jb17 CHLORINATED WATER CONTAINING ORGANIC SUBSTANCES LEVENTON 0 L ALL-UNION RES. INST. WATER SUPPLY SEWER SYST. HYORAUL.-ENG. STRUCT. HYOROGEOL. ENG. , MOSCOW, USSR. GIG SANIT O (1). 1980. 52-53. Language: RUSSIAN Coden: GISAA Descriptors: REVIEW HUMAN VINYL CHLORIDE CHLOROFORM METHANE ACETOPHENONE HALOID DERIVATIVES ACETALDEHYDE FULVIC-ACIO ACETONE CARCINOGEN WATER POLLUTION Concept Codes: ECOLOGY-WATR RESRCH,FISHERY BI0L(075t7): COMPARATIVE 8 IOCHEM-GENL STUDIES( 10010); BIOCHEM METH-GENERAL- (10050): BIOCHEM STUD - GENERAL( 10060); PATHOLOGY-COMPARATIVE(12503); MINERALS( 10069); TOXICOL-ENVIRONMNTL, INDUSTR(*22506): NEOPLSMS/NEOPL AGNTS-CAR- CI NOGENS{ * 24007): ENVIRON HEALTH-S EWG D1SP.SANITAR(* 37014 ); ENVIRON HEALTH-AIR,WATR,SL MICRO-FD/BEV SP CNTAM(39002) POLLN( *370 1 5 ) ; FOOD/INDUS Blosystemat1c Codes: H0M1NIDAE(86215) 20053547 MAXIMUM PERMISSIBLE CONCENTRATION OF VINYL CHLORIDE IN AIR MURATOV M M; TAKHIROV M T UZB. RES. INST. SANIT. HYG. OCCUR. OIS.. TASHKENT, USSR. GIG SANIT O (11). 1979 (RECD. 1980). 74-76. Coden: GISAA Language: RUSSIAN Descriptors: NOTE HUMAN RAT CARCINOGEN RNA IMMUNITY MUTAGENICITY TEMPERATURE LIVER KIONEY BRAIN HEART OCCUPATIONAL HEALTH Concept Codes: GENL B IOL-INST I TUT,ADMIN,LEG ISLN(00508): C YT O LOGY/CY T OCI1EM-AN IMAL(*02506); BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-NUCL ACD,PURNS.PYRM(10062); REPLICATN,TRANSCRIPT- N,TRANSLATE 10300): EXTERN EFF-TEMPERATURE( 10614); PATHOLOGY - - COMPARATIVE( 12503); METABOLISM-GENL STUD,METAB PATHW( 13002>; METABOLISM-NUCL ACD.PUR I NS,PYRIM( 13014) ; DIGESTIVE SYST-GENL STUOS,METHS( 14001); DIGESTIVE SYST-PATHOLOGY(* 14006); CARDIOV- ASC SYST-GENL STUDS,METHS(14501); CAROIOVASC SYST-HEART PATHOLOGY(* 14506); URIN SYST/EXT SECR-GEN STUD.METH( 1 550 1 ); URIN SYST/EXT SECR-PATHOLOGY{*15506): NERVOUS SYST-GENL STUDS,METHS(20501 ): NERVOUS SYST-PATHOLOGY(*20506); TOXICOL-E- NVIRONMNTL,INDUSTR{22506 ) : TEMPERATURE-GENL.METHS{2 3001): NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); 1MMUNOL/IMMUNOCHEM-- GEN ME TH(34 502); ENVIRON HE ALTH-OCCUPATNL HEALTH( * 37013): ENVIRON HEALTH-AIR.WATR.SL POLLN(* 37015) 8losystematIc Codes: HOMINIDAE(86215); MUR 1 DAE(8637 5) Descriptors: HUMAN LYMPHOCYTE MUTAGEN CARCINOGEN Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(*02508); GENETICS/C Y - TOGENET-HUMAN(*03508); BIOCHEM STUD-GENERAL( 10060): QIOCIIEM STUD-NUCL ACD.PURNS.PYRM( 10062): METABOLISM-NUCL ACD.PUR I NS.P- YRIM(13014): BLOOD/BODY FLDS-BLOOD CELL STUDS( * 15004 ) ; BLOOD/BODY FLDS-LYMPHAT TISS.RES( 15008); TOXI COL -ENVIRONMNTL- .INOUSTRC*22506); NEOPLSMS/NEOPL AGNTS-CARC INOGENS(24007); TISS CULTURE-APPARAT.METHS.MEDIA(32500); IN VITRO STUDS-CELLU- LR.SUBCELL(32600): ENVIRON HEALTH-AIR,WATR.SL POLLN(*37015) Blosystemat1c Codes: HOMINIOAEI86215) 200429 t7 REPEATABILITY AND REPRODUCIBILITY OF MEASUREMENTS OF VINYL CHLORIDE CONCENTRATIONS IN MATERIALS AND ARTICLES MADE OF POLY VINYL CHLORIDE ROSSI L; WAI BE L d; VOM BRUCK C G COMMUNAUTES EUROPEENNES. DIRECTORAT GENERAL III. BRUXELLES. BELGE. FOOD COSMET TOXICOL Language: ENGLISH 18 (5). 1980. 527-536. Coden: FCTXA Descriptors: REVIEW CHROMATOGRAPHY STATISTICS Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500): BIOCHEM METH-GENERAL(* 10050): BIOCHEM STUD-GENERAL( 10060):1 B1OPHYS-GENERAL 8I0PHYS TECH( 10504); MOVEMENT( 12100 ); TOXICOL-GENL/EXP STUDS.METHS(*22501); TOXI COL-ENVIRONMNTL.IND USTR ( 22506 ) : ENVIRON HEALTH-MISCELL STUDS(*37019) 20047608 CYTO GENETIC ANALYSIS IN WORKERS OCCUPATIONALLY EXPOSED VINYL CHLORIDE ROSSNER P; STRAM R J; NOVAKOVA U; LAMOL V INST. HYG. EPIDEMIOL.. 100 42 PRAGUE.. CZECH. MUTAT RES 73 (2 ). 1980. 425-428. Coden: M1JREA Language: ENGLISH TO DIALOG le5: BIO; 138422 R&S A7502:RRM2402(See F11e55) (c. B10SIS 1902} (Item 263 of 058) User 3614 25Jan83 2068 20042661 OCCURRENCE OF PHTHALATE ESTERS IN HUMAN KIDNEY OVERTURF M L; CAPRIOLI R M DRUILHET R ; KIRKENDALL W M; LIEHR J G; DEP. INTERN. MED., UNIV. TEX. MED. SCH.. HOUSTON, TEX. ANNUAL MEETING OF THE AMERICAN FEDERATION FOR CLINICAL RESEARCH, SOUTHERN SECTION, JAN. 18-20. 1979. CLIN RES (6). 1970 (RECO. 1979). 781A. Coden: CLREA 26 Language: ENGLISH Descriptors: ABSTRACT POLY VINYL CHLORIDE DI-N BUTYL PHTHALATE DI-2 ETHYLHEXYL PHTHALATE NEPHRO SCLEROSIS CHROMATOGRAPHY LIPID TEXAS USA ENVIRONMENTAL TOXICITY WASTE DISPOSAL Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS,REVW(00520): CYTOLOGY/CYTOCHEM-HUMAN{02508); SOCIAL BIOL/HUMAN EC0LOGY(O55- 00): BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(10060): BIDCHEM STUD-LIPIOS(10066); BIOPHYS-GENERAL BIOPHYS TECH(10504); MOVEMENT{121OO); METABOLISM-GENL STUD/METAB PATHW( 13002 ) ; METABOLISM-LIP10S( 13006); URIN SYST/EXT SECR-GEN STUD,METHf 15501 ) : URIN SYST/EXT SECR-PATHOLOGY( * 15506); TOXI COL -ENV1RONMNTL,INDUSTR(*22506); ENVIRON HEALTH-SEWG DISP.SANITARO7014); ENVIRON HE ALTH-AIR , WAT R , SL POLLNl *37015) Blosystemntlc Cories: HOMINIDAE(86215) 20038503 BIOCHEMICAL AND IMMUNOLOGICAL SURVEILLANCE OF A GROUP OF VINYL CHLORIDE WORKERS PAGE M; DELORME F; AUDETTE M DEP. BIOCHEM., UNIV. LAVAL. LAVAL. OUE.. CAN. 4TH INTERNATIONAL SYMPOSIUM OF THE INTERNATIONAL SOCIETY FOR PREVENTIVE ONCOLOGY ON CANCER DETECTION AND PREVENTION. LONDON. ENGLAND, JULY 26-31. 1980. CANCER DETECT PREV 3 (1). 1980. NO PAGINATION. Coden: CDPRO Language: ENGL ISH Descriptors: ABSTRACT CARCINOGEN ANGIO SARCOMA CARCINO EMBRYONIC ANTIGEN FERRITIN ALKALINE PHOSPHATASE GLUTAMIC OXAL ACETIC TRANS AMINASE GLUTAMIC PYRUVIC TRANS AMINASE LACTIC DEHYDROGENASE Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00520): CLIN 8I0CHEM-GENL STUDIES(* 10006); BIOCHEM STUO-GENERAL( 10060); BIOCHEM' STUD-PROTEINS,PEPTIDES,AMINO ACD(10064); BIOCHEM STUO-CARBOHYOR.( 10060); ENZYMES-PHYSIOLOGICAL STUOIES( 10008): MET ABOLISM-GENL STUD , METAB PATHW( 13002): METAIJOLISM-CARBOHYDR- ATES( 13004); METABOLISM-PROTNS,PEPTDS.AM ACOS( 13012); CARDIOV- ASC SYST-BLD VESS PAT MOL{14500): TOXICOL-ENVIRONMNTL.INDUSTR- (*22506); NEOPLSMS/NEOPL AGNTS-IMMUNOl.OGY( * 24003); NEOPLSMS/N- EOPL AGNTS-CARC1NCJGENS(*24007); DEVELOPMNTL B1OL-GENL.DESCR1P- TIVF(25502) : IMMUNOL/IMMUNOCUEM-GEN MEm{* 34602) ; ENVIRON HEAL III -(JCCUPAINL HEALTH! *37013) Blosysloraat1c Codes: HOMIN[DAE{86215) MED. RES. COUNC. RES. UNIT EPIDEMIOL. PREV. MED.. UNIV. WEST. AUST. . NEDLANDS. WEST. AUST. . AUST. 4 TH INTERNATIONAL SYMPOSIUM OF THE INTERNATIONAL SOCIETY FOR PREVENTIVE ONCOLOGY ON CANCER DETECTION AND PREVENTION, LONDON, ENGLAND, JULY 26-31. 1980. CANCER DETECT PREV 3 (1). 1980. NO PAGINATION. Coden: CDPRO Language: ENGL ISH Descriptors: ABSTRACT HUMAN ARSENIC ASBESTOS CHROMIUM SOOTS TARS MINERAL OILS VINYL CHLORIDE CARCINOGEN OCCUPATIONAL CANCER Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-LIPIDS( 10066); MINERALS( 10069); TOXI COL-GENL/EXP STUDS.METHS(* 22501): T OX I COL -ENVIRONMNT L,INDUSTR(22506); NEOPLSMS/NEOPL AGNTS-CARC- I NOGENS { * 2.4 007 ) ; ENVIRON HE ALTH-OCCUP ATNL HE ALTH( * 370 13 ) B1osystemat1c Codes: HOMINIDAE(86215) 20033681 CORRELATION OF INTERFACIAL ENERGIES WITH PLATELET RETENTION ON ARTERIAL ENDOTHELIUM AND ARTIFICIAL SURFACES MCIVER D J L; COLES J G: SCHURCH S DEP. PHARMACOL., UNIV. WEST. ONT.. LONOON, ONT. ANNUAL MEETING OF THE CANADIAN SOCIETY FOR CLINICAL INVESTIGATION. OTTAWA, ONT., CANADA, OCT. 1-3, 1900. CUN RES 20 (3). 1980. 6GOA. Coden: CLREA Language: ENGLISH Descriptors: ABSTRACT THROMBOSIS POLY ETHYLENE POLY SILOXANE POLY VINYL CHLORIDE Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520>; CYTOLOGY/CYTOCHEM-ANIMAL(02 506): BIOCHEM STUD-GENERAL( 10060); 8 IOPHYS-8!OENGINEERING(*10511); CAROIOVASC SYST-GENL STUDS.ME- THSC 14501): CAROIOVASC SYST-ANATOMY(* 14502): CAROIOVASC SYST-BLD VESS PATHOL(*14508): BLOOD/BODY FLOS -BLOOD CELL STUDS(15004) 20039477 EPIDEMIOLOGIC IDENTIFICATION OF CARCINOGENS ARMSTRONG B K DIALOG Ftle5: BIOS IS Pre R&S 138423 IRM2402(See F11e55) (c. BIOSIS 1982) (Item 267 of 858) User 3614 25Jan83 2069 20021149 COMPLICATIONS FROM POLY URETHANE AND POLY VINYL CHLORIDE UMBILICAL ARTERY CATHETERS WIGGER J: PEREZ A; KOONS A; BOYO L DIV. NEONATOL.. COLL. PHYSICIANS SURG.. COLUMBIA UNIV.. NEW YORK, N.Y., USA. MEETING OF THE AMERICAN PEDIATRIC SOCIETY AND THE SOCIETY FOR PEDIATRIC RESEARCH, SAN ANTONIO. TEX.. USA, APRIL 30-MAY 2. 1980. PEDIATR RES PEREB 14 (4 PART 2). 1980. 592. Coden: Language: ENGLISH Descriptors: ABSTRACT HUMAN NEW BORN THROMBOSIS Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS,REVW(00520): BIOCHEM STUD-GENERAL( 10060): BIOPHYS-B10ENG INEERING(* 1051 1): CARD IOVA SC SYST-GENL STUDS.METHS(* 14501); CARDIOVASC SYST-BLD VESS PAIHOL(* 14508): BLOOD/BOOY FLDS-BLOOD.LYMPH STUD( 15002); BLOOO/BODY FLDS-BLD,LYM,RES PATH(* 15006) ; TOXI COL-GENL/EXP STUDS,METHSt*22501); PEDIATRICS(*25000): OEVELOPMNTL SIOL-GEN- L.DESCRIPTIVE(*25502) Blosystemat fc Codes: HOMINIDAE(86215) . 20019832 HYGIENIC EVALUATION OF FIRE DE CONTAMINATION OF WASTES FROM THE PRODUCTION OF DI CHLORO ETHANE AND VINYL CHLORIDE/ LUBYANSKII M L; LEVINA M M; GRONSBERG E SH: MIKHNO V B GORKI RES. INST. IND. HYG. OCCUP. . DIS. . MINIST. HEALTH RSFSR. GORKI. USSR. GIG SANIT 0 (3). 1979. 61-63. Coden: GISAA Language: RUSSIAN Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM-GASESt 10012 ) : BIOCHEM METH-GENERAL( 10050); BIOCHEM STUD-GENERAL{ 10060); TOXICOL -ENVIRONMNTL. INDUSTR(22506); ENVI RON HEALTH-SEWG DISP.SANITAR(* 37014); ENVIRON HE ALTH-A IR.WATR- .SL PDLLN(*37015) 200 1316G A NEW CELL CULTURE BIO COMPATIBILITY TEST SYSTEM FOR MATERIALS 1MA1 Y; WATANABE A; MASUHAnA E INST. MED. DENT. ENG.. TOKYO MED. DENT. UNIV., SURUGAOAI , KANDA, TOKYO, JPN. 25TH MEETING OF THE AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS. NEW YORK. N.Y.. USA, APRIL 20-21, ARTIF INTERN ORGANS 25 (0). 1979 1RECD. Coden: TAIOA 1979. TRANS AM SOC 1900). 299-304. Language: ENGL ISH Descriptors: HUMAN GINGIVAL CARCINOMA CELL LINE SILICONE RUBBER TEFLON POLY URETHANE POLY VINYL CHLORIDE D1RtCT CONTACT METHOD Concept Codes: GENL . 8 IDL-SYMPOSIA,PROCDNGS.REVW{00520); CYTOLOGY/CYTOCHEM-HUMAN(*02508); BIOPHYS-BIOENGINE ERING(*10511): DENTAL/ORAL BIOL- PATHOLOGY( 19- 006); ' NEOPLSMS/NEQPL AGNTS-CELL CULTURE - APPARAT,METHS.MEDIA! *32 5(701 LINE(24005); T1SS B losyslemat1c Codes: HOMINIDAE(86215) 20010985 CONTACT DERMATITIS 1980 HUORTH N DEP. DERMATOL.. GENTOFTE HOSP.. DK-2900 HELLERUP, DEN. 60TH ANNUAL MEETING OF THE BRITISH ASSOCIATION OT DERMATOLOGISTS. OXFORD, ENGLAND. JULY 9-12. 1980. DERMATOL 103 (IB). 1900. 19-20. Coden: B JDSA BR d Language: ENGLISH Descriptors: HUMAN KERATOTIC ECZEMA IRRITANT HANO ATOPIC DERMATITIS HANO PSORIASIS FRAGRANCE MIX PATCH TEST EPOXY CHROMATE CEMENT FERROUS SULFATE DIETARY NICKEL SESOUI TERRENE LACTONES OUINONES POLY VINYL CHLORIDE PLASTICS PROPYLENE GLYCOL PARABENS LANOLINS Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520); BIOCHEM STUD-GENERAL(10060); MINERALS(10069): CHORDATE BODY REGNS-EXTREMITIES! 1 1318); PATHOLOGY-COMPARATIVE( 12503); PATHO LOGY -0 IAGNOSTIC( 12504 ) ; PATHOLOGY-I NFLAMMATN.INFLAM OIS( 12508) ; NUTRITION-MINERALS(* 13206); NUTRITION-PROPHYLAC.THERAP DIETS(* 132 1S ) ; INTEGUMENT SYST-GENL STUDS.METHS( 1850 1 ) ; INTEGUMENT SYST-PATHOLOGY(* 18506); PHARMACOL-DRUG ME TAB,ME T AB STIMU(22003): PHARMACOL-IMMUNO PROCES.ALLERGY(22018); TOXICOL- -ENVIRONMNTL,INOUSTR(*22506); IMMUNOL/1MMUNOCHEM-GEN METH(345- 02): IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(*34508); ALLERGY(*35500): ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013); ENVIRON HE A L T H - A I R . W - A TR.SL POLLN{*37015); PLANT PHYSIOL-CHEM CONST ITUENTS(5 1522 ) ; FORESTRY AND FOREST PRODUCTS(53500) B iosys tematic MOMINI0AE(86215) Codes: SPERMATOPHYTA-UNSPECIFIE0(25000) : 20010387 DETERMINATION OF VINYL CHLORIDE IN POLYMERIC MATERIALS MODELED MEOIA AND FOOD PRODUCTS TARASOVA N A; KATAEVA S E MOSC. TECHNOL. INST. MEAT DAIRY IND.. MOSCOW, USSR. GIG SANIT O (3). 1979. 48-50. Coden: GISAA Language: RUSSIAN Descriptors: CHEESE GAS CHROMATOGRAPHY Concept Codes: BIOCHEM ME III-GENERAL( *10050); BIOCHEM STUO-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH(10504); MOVEMENT! 12100) ; FOOD TECH-GENL STUDS,METHS( 13502); FOOD TECH-DAIRY PRDDUCTS( 1 35 18 ) ; FOOD TECH-EVALNS PHYS.CHEM PROPS! 13530); TOXICOL-GENL/EXP STUDS,METHS(22501) D I ALO le5: SIOSIS Prevlews 77-03/Jan i R&S 138424 ) (c. BIOSIS 1982) (Item 272 of 858) User 3614 25jan83 2070 20010361 PHARMACO KINETICS OF VINYL CHLORIDE IN RHESUS MONKEYS RATS AND MAN BUCHTER A; FILSER J G; PETER H: BOLT H M INST. OCCUP. SOC. MED.. UNIV. COLOGNE. COLOGNE. W. GER. 2ND INTERNATIONAL CONGRESS ON TOXICOLOGY. BRUSSELS, BELGIUM. JULY 6-11, 1900. TOXICOL LETTERS (AMST) O {SPEC. ISSUE 1). 1980. 22 4. Coden: TOLED Language: ENGLISH Descriptors: ABSTRACT Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(005 20); BIOCHEM STUD-GENERAL{10060): PHYSIOLOGY-COMPARATIVE(12003); PATHOLOGY-COMPARATtVE(12503); METABOLISM-GENL STUD,METAB PATHW( 13002); TDXI COL-GENL/EXP STIJOS,METHS( *22501 ); TOXICOL-ENVIRONMNT L, INOUSTR(2 2506); NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(2 4007) ; ENVIRON HEALTH-A IR.WATR.SL P0LLN(37O15) Blosysternat1c Codes: CERCOPITHECIDAE(86205); HOMINI DAE{8621 5); MUR 10AE(8637 5) 20003781 VINYL CHLORIDE DIRECT OR INDIRECT MUTAGEN DE MEESTER C; PONCELET F; ROBERFROID M; MERCIER M LAB. BIOTOXI COL., EC. PHARM.. UNIV. CATHOL. LOUV. 73.69. 73 AVE. E. MOUNIER. B-1200 BRUXELLES, BELG. tOBTM MEETING OF THE SOCIETE BELGE DE BIOCHIMIE (BELGIAN BIOCHEMICAL SOCIETY), LOUVAIN-LA-NEUVE. BELGIUM, FEBRUARY 24 . 1979. ARCH INT PHYSIOL BIOCHIM 620-62 1 . Coden: AIPBA 87 (3). 1979 (RECO. 1980). Language: ENGLISH Descriptors: NOTE SALMONELLA-TYPHIMURIUM STRAIN TA-1530 MOUSE LIVER S*9 FRACTION HUMAN CHLORD ACETALDF1 !YDE CARCINOGEN INDUSTRIAL CHEMICAL OCCUPATIONAL EXPOSURE Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS.REVW(00520): CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENETICS/CYTOGENET-ANIMAL(*03506); GENETICS/CYTOGENET-HUMAN(*03508); BIOCHEM STUD-GENERAL{10060): BIOCHEM STUD-NUCL ACO.PURNS,PYRM(10062); METABOLISM-GENL STUD,METAB PATHW( * 13002 ); METABOLISM-NUCL ACD.PUR I NS.PYRIM( * 1 - 3014); DIGESTIVE SYST-PHYSIOL.BIOCHEM( 14004); TOXICGL-GENL/EXP STUDS,METHS(*22501); TOXICOL-ENVIRONMNTL,INDUSTR(22506); NEO PLSMS/NEOPL AGNTS-CARCINOGENS!*2 4007); BACTERI A- PHYSIOLDGY.BI OCHEM I S T R Y ( 3 10OO ) ; BACTERIAL ANO VIRAL GENET ICS(31500): MICROBIOLOG APPARAT.METHS.MED IA(32000): IN VI1R0 STUDS-CELLUL- R . SUBCELL ( 32G00) ; ENVIRON HE AL TM - OCCUP A TNL HE A1. TH ( * 3 70 1 3 > B losys tenia t Ic Codes : ENT E ROB ACT ER I ACE AE ( 04 8 10) : 110MIN [ OAE ( 8- 6215): MURIDAE(86375) PRDBL GEMATOL PERELIV KROVI 54-56. Coden: PGPKA 24 (It). 1979 (RECO. 1980). Language: RUSS I AN Descriptors: HUMAN POLY VINYL CHLORIDE BAGS PRESERVATIVE TSOLIPK 7B CENTRIFUGATION EPINEPHRINE CARDI 0VASCULAR- DRUG F ACTOR -VItI Concept Codes: GENERAL LABORATORY APPARATUS(*01006) : CYTOLOGY/CYTOCHEM-HUMAN( `02508): BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUO-PROTEINS.PEPTIDES.AMINO ACO( 10064); BIOPHYS-GENE - RAL BIOPHYS TECH( 10504); EXTERN EFF-TEMPERATURE( 106 14 ) ; BLOOO/BODY F LOS -GENL STUOS.METHS(* 1500l); BLOOO/BOOY FLOS-BLOOD,LYMPH STUO(15002); BLDOO/BODY FLOS-BLOOD CELL STUOS( * 15004); ENDOCRINE SYST-ADRENALS( 17004); PHARMACOL-CL IN- ICAL PHARMACOL(22005) ; PHARMACOL-BLOOD,HEMATO AGENTS(2200B ) : PHARMACOL-CAROIOVASC SYST(22010); TEMPERATURE-GENL.METHS(23001) BlosystematIc Codes: H0MIN1DAE(86215) 20000859 DEMONSTRATION OF POTASSIUM ELECTRODE SUITABLE FOR USE IN-VIVO IN MAN BAND D M; LINTON R.A F; TREASURE T DEP. PHYSIOL.. ST. THOMAS'S HOSP. MED. SCH.. LONDON SE1 7EH, ENGL.. UK. BIENNIAL MEETING OF THE EUROPEAN SECTION OF THE INTERNATIONAL SOCIETY FOR HEART RESEARCH. DIJON, FRANCE. SEPT. 13-15. 1979. J MOL CELL CARDIOL 11 (SUPPL. 2). 1979 (RECO. 1980). 2. Coden: JMCDA Language: ENGLISH Descriptors: ABSTRACT BLOOD POTASSIUM POLY VINYL CHLORIDE Concept Codes: GENL B1OL-SYMPOSI A.PROCDNGS.REVW(00520): BIOCHEM METH-MINERAl.S(*10059): MINERALS( * 10069); BIOPHYS-GENE- RAL BIOPHYS TECH(*10504); BLODD/BODY FLDS-BLOOD.LYMPH S T UO( * 15002) B 1 osys terna t 1 c Codes: HOMINIDAE ( 862 1 5 ) 20000931 USING PLASTIC CONTAINERS FOR . THE PREPARATION OF A THROMBOCYTE CONCENTRATION AT 22 CELSIUS CHERNYAK N B; EVLENT'EVA N E; GURTOVOI I M; KOSHEVAYA V P; KHAMETOVA R N CENT. INST. HE.M AT OL . BLOOD TRANSriJS.. MIN1S1. HEALTH USSR, MOSCOW, USSR. DIALO 1 e5 : BIOSIS Preview's 77-83/Jan BA7502;RRM2. R&S ^425 SIS 1982) (Item 276 of 858) Usor 3614 25J* 207 1 70082286 PHOSGENE IN THE THERMAL DECOMPOSITION PRODUCTS OF POLY VINYL CHLORIDE GENERATION DETECTION AND MEASUREMENT BROWN J E; BIRKY M M CENT. FIRE RES., US DEP. COMMERCE, NATL. BUR. STAND., WASHINGTON. D.C. 20234, USA. J ANAL TOXICOL 4 (4). 1980. Language: ENGLISH 166-174. Coden: JATOO An analytical study was made to determine whether the toxic product carbonyl chloride (phosgene) Is formed during the thermal decomposition of poly(vlnyl chloride), PVC. Four methods of decomposition were studied: thermal degradation of PVC In a resistIvely heated furnace, electrical over loading of a PVC clad wire, electrical arcing betueon electrodes partially covered with PVC, and electric arc Initiated flaming combustion In a cup furnace. Significant quantities of phosgene were generated from PVC by the electric arc method. Lesser amounts were found In the other scenarios. The measurements, identification and quantification of phosgene In the decomposition product. were obtained through the use of gas chromatography, IR spectroscopy and mass spectroscopy. While the study was not mechanistic In nature, phosgene Is postulated to result from secondary reactions of the PVC products. Reaction mechanisms are suggested. Descriptors: TOXICITY Concept Codes: BIOCHEM METH-GENERAL( 10050); BIOCHEM STUO-GENERAU 10060); BIOPHYS-GENERAL B10PHYS TECH{10504); BIOPHY S-MOLECUL PROP,MACR0M0LEC( 10506); EXTERN EFF-ELECTR.MAG NET , GRAVITY ( 106 10) ; EXTERN EFF-H0T(106 18); MOVEMENT( 12100): TOXICOL-GENL/EXP STUDS,METHS{* 22501 ): TEMPERATURE-GENL.METHS(*23001 ) STUO-NUCt. ACO , PURNS . PYRM( 10062 ) : BIOCHEM STUD - PRO! E I NS . P E P T I 0 - ES,AMINO ACD{ 10064); META80LISM-GENL STUD.MET AB PATHW( 13002 ) : MET ABOLISM-PROT NS.PEPTDS.AM ACOS{ 13012): METABOLISM-NUCL ACD.PURINS.PYRIMt13014); RESPIRATORY SYST-GENL STUD.METHS(160- 01); RESPIRATORY SYST-PATHOLOGY(*16006); PHARMACOL-DRUG METAB,METAB STIMU{* 22003); ROUTES OF IMMUNIZ.INFECT.THERAP(22 - 100): TOXICOL-GENL/EXP STUDS.METHS(*22501): TGXICOL -ENVIRONMN- T L,1NDU STR(22506); NEOPLSMS/NEOPL AGNTS-CARC INOGENS(24007 ); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-A IR.WA- TR.SL POLLN(37015); PEST CONTRL GENL/PESTICS/HERBICS(54600) B1osysternat1c Codes: MUR I DAE(8 6375) 70082270 CHARACTERISTICS OF HALO ETHYLENE INDUCED ACETONEMIA IN RATS FILSER d G; BOLT H M AST. TOXIKOL. . PHARMAKOL. INST., UNIV . MAINZ. OBERE ZAHLBACHER STR. 67, D-6500 MAINZ, W. GER. ARCH TOXICOL 45 (2). 1980. 109-116. Codon: ARTOD Language: ENGLISH A series of halogenated ethylenas {vinyl chloride, vinyl i done fluoride, els- and trails- 1,2 - d t ch 1 oroe thy 1 ene, perch 1oroethy 1ene) induces increased acetone exhalation In rats. Exposures of differently pretreated rats to vinylIdene fluoridn suggost that a metnbollto of the holoethyleno must bo involved In eliciting this formation of ncntono. This conclusion Is based on dependence of acetone exhalation on the concentration of vIny1 1 dene fluoride; effect of Inducing agents [phenobnrblta1 and ODT]; effect of pyrarole, a motnbollc l.nlillil tor; offoct of cystoino; effect of hypoxia amt the time course of acetone nxhnlntIon. Descriptors: PYRAZOLE METABOLIC-DRUG PHENO BARBITAL DDT VINYL CHLORIDE VINYL 1OENE FLUORIDE CIS- 12 01 CIU.ORO ETHYLENE TRANS-1 2 DI CHLORO ETHYLENE PER CHLORO ETHYLENE HYPOXIA CYSTEINE EXHALATION Concept Codes: COMPARATIVE B10CHEM-GENL STUDIES( 100 10); BIOCHEM-GASESt10012); BIOCHEM STUD-GENERAL(10060); BIOCHEM DI ALOC? le5: BIOSIS Previews 77-83/Jan BA7502;RRM24Q2(See File55) (c. R&S 138426 of B58) User 3614 25janB3 207 2 70079430 A GENERAL SCHEME FOR THE INCORPORATION OF PHARMACO KINETICS IN LOW DOSE RISK ESTIMATION FOR CHEMICAL CARCINOGENESIS VINYL CHLORIDE EXAMPLE ANDERSON M W; NOEL 0 G; KAPLAN N L LAB. PHARMACOKINETICS. NATIONAL INST, ENVIRONMENTAL HEALTH SCIENCES, RESEARCH TRIANGLE PARK. NORTH CAROLINA 27709. TOXICOL APPL PHARMACOL 55 ft). 1980. 154 -J61. Coden: TXAPA Language: ENGLISH A general scheme is proposed which relates the carcinogenic responses to the amount of DNA-carcinogon adduct formed instead of applied dose. Based on the present understanding of the mechanism of carcinogenesis, may be a more rational approach to the low-dose extrapolation problem. In addition to specifying the low-dose extrapolation routine. It is necessary in this scheme to construct a pharmacokinetic model relating exposure concentration to the amount of DNA-chemical adduct formed. Two pharmacokinetic models are constructed for vinyl chloride. Low-dose risk* estimates are determined from dose-response functions corresponding to the problt and multistage models. The estimates obtained using the probit model vary considerably when the pharmacokinetics parameters are changed whereas for the multistage model the low-dose estimates have less variability, varying in genera) by no more than one order of magnitude. This is not unexpected since the probit dose-response function is very flat in the low-dose region whereas the multistage dose-response function is analytic. In some cases a detailed pharmacokinetic study of the carcinogen may be as important as the bloassay study for low-dose and across-species extrapolation. It Is important to realize that even though the Incorporation of pharmacokinetics into the low-dose estimation process better reflects reality, it does not help In resolving the Issue of which underlying mode! to use for the low-dqse extrapolation, o.g., probit vs. mu 1tis t age. Descriptors: DNA PHARMACO KINETIC MODEL Concept Codes: MATHEMATIC BIOL/STATIST IC METH(04500): COMPARATIVE BIOCHEM-GENL STUD IESt 10OI 0): 8I0CHEM STUD-GENERAL- (10060): BIOCHEM STUO-NUCL ACD.PURNS,PYRM{10062): BIOPHYS-MDL- ECUL PROP,MACROMOLECt 10506); BIOPHYS-BIOCYBERNET[CS(* 10515); METABOLISM-GENL STUD,METAB PATHW(13002); METABOLISM-NUCL ACD.PURINS.PYRIMt 13014) : TOXI COL-GENL/EXP STUDS,ME1HS< * 2250 i } ; TOXICOL -ENVIRONMNTL, INDUSTR(2 2506); NEOPLSMS/NEOPL AGNTS- CARO - I NOGENS(*24007); ENVIRON HEALTH-A IR.WATR,SL P0LLN(370I5) B(osystematIc Codes: VERTEBRATA-UNSPECIFIE0(85150) occupa tional details for those cases agreed as ASL by a pane! of h1stopa tho legists. Cases (28 men. 6 women and t infant girl) were agreed as ASL. The Increase In the Incidence of ASL observed in recent years was attributable to Thorotrast (thorium dioxide) usage (8 cases) and exposure to vinyl chloride (2 cases) in the past. In its clinical presentation and prognosis ASL resembled primary liver careinoma. except that extrahepatic metatases were found in only 8 (23%) cases, and hemoper1toneum was more common in those cases due to Thorotrast. There is a possible Increased risk of ASL In ttie electrical and plastics fabrication industries, but information on exposure was Inadequate to implicate speciffc chemicals. The clinical features of 1 case was Indicative of As intoxication. but medications in the other patients were not of etiological importance. Descriptors: HUMAN THOROTRAST ARSENIC VINYL CHLORIDE HEMO PERITONEUM METASTASIS ELECTRTCAL. INDUSTRY PLASTICS INDUSTRY HISTO PATHOLOGY Concept Codes: MICROSCOPY-HISTOL,HISTOCHEM TCH(O1056): CYTOLOGY/CYTGCKEM-HUMAN{02508); SOCIAL BIOL/HUMAN EC0L0GY(O55- 00); RADIATION BIOL-RAOTN.ISOTOP TECH(06504); COMPARATIVE BIOCHEM-GENL STUD IES( 10O10); BIOCHEM STUD-GENERAL( 10060); MINERALS( 10069); ANATOMY/HISTOL-MICRO,ULTRAM ICRSC( 1 i 108): CHO- RDATE BODY REGNS-THORAX(1 I 3 1 2); METABOLISM-GENL STUD,METAB PATHW(13002); MINERALS(13010); DIGESTIVE SY5T-GENL STUDS,METUSt14001): DIGESTIVE SYST-PATHOLOGY(*14006); CARDIOV- ASC SYST-GENL STUOS,METHS(14501); CAROIOVASC SYST-BLD VESS PATHOL ( * 14 508 ) ; COELOM MEMBRANES , ME SENTERI ES , ETC( * 18200 ) ; PHARMACOL-DRUG METAB,METAB ST I MU(2 2003): PHARMACOL -CLINI CAL PHARMACOL(22005); TOXICOL-PHARMACOLOGICAL{*22504); TOXICOL-EN- VIRDNMNTL.INDUSTR(*22506); NEOPL'SMS/NEOPL AGNTS-CARC I NOGENS( - 24007); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013}: EPI DEM IOL-OR GANIC DIS,NEOPLASMS(*37054) B1osystematic Codes: HOMINIDAE(862i5) 70079474 ANGIO SARCOMA OF THE LIVER ANNUAL OCCURRENCE AND ETIOLOGY IN GREAT BRITAIN UK BAXTER P J: ANTHONY P P; MACSWEEN R N M; SCHEUER P J EMPLOYMENT MED. ADV. SERV., LONDON NWt 50T. ENGL., UK. BR d IND MED 37 (3). 1980. 213-221. Coden: BJIMA Language: ENGLISH The annual occurrence of angiosarcoma of, the liver (ASL) 1 n Britain from 1963-1977 was studied. Including clinical and DIALOG^ 1 e5 : BIOSIS Previews 77-83/Jan BA7502;RRM2402(See File55) R&S 138427 280 of 858) User 3614 25jan83 2073 70072306 ISOLATION AND CHARACTERIZATION OF A SULFATED GLYCO PROTEIN FROM A TRANSPLANTABLE COLO RECTAL ADENO CARCINOMA OF RATS/ MUNAKATA H; YOSIZAWA Z DEP. BIOCHEM., TOHOKU UNIV. SCH. MED., 2-) SEIRYO-MACHI. SENDAI . MI VAGI 980, JPN. 810CHIM BIOPHYS ACTA BBACA 623 (2). 1980. 412-417. Coden: Language: ENGLISH A transplantable colorectal adenocarcinoma from rats of the ACI/N strain was extracted with 5 mM EDTA (pH 7.0), and fractionated by gel filtration on sepharose <10. followed by preparative poly(vinyl chloride) zone o1ectrophresis. An acidic glycoprotein (SGP) thus obtained was shown to be homogeneous by e1ectrophoresis on cellulose acetate membrane and on sodium dodecyi sulfate agarose gel. SGP contained 61.97. carbohydra t e, 28.97. total amino acids and 1.47. sulfate. The major monosaccharides in SGP were galactose, glucosamine and ga1 actosamine. Small quantities of sialic acid, L-fucose and mannose wore also present. Threonine, serine, proline, glutamic acid and aspartic acid were the major amino acids of the protein moiety. Concept Codos : BIOCHEM METH-PROTNS. PEPTDS, AM AC( 10004 ); BIOCHEM METH-CARBOHYORATES( 10058); BIOCHEM STUD-GENERAL( 10060) ; BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(* 10064): BIOPHYS-GENERAL BIOPHYS TECH<10504); BIOPHYS-MOLECUL PROP,MACR0M0LEC(10506); ANATOMY/HISTOL-REGEN,TRANSPLANT(11107) ; M0VEMENT( 12 too); META80LISM-CARBOHYDRATES( I 3004); METABOLI SM - PROTNS , P E PTD S . AM AC0S(* 130 12); DIGESTIVE SYST-PATHOLOGY(*1 - 4006) ; NEOPLSMS/NEOPL AGNTS-BIOCHEM{`2 4006) Blosystematic Codes: MUR I DAE(86375) the Immobilized enzyme for the hydrolysis of casein were higher than those of soluble bromelain; the immobilized bromelain showed no significant loss in enzyme activity after 3 mo. storage at 4.degree. C. In the presence of 0.05 M L-cystelne or 2-mercaptoethano1, the caselnolytic activity was Increased by 65 or 87%, respectively. When casein was used as substrate. the batch-type operational half-life at 40.degree. C and pH 7.O was 48 h, whereas the half-life at 30.degree. C and pll 7.0 was extended to 15 days. Descriptors: PINEAPPLE STEM JUICE FOOD PROCESSING PH TEMPERATURE CASEIN SUBSTRATE Concept Codes: BIOCHEM METH-PROTNS.PEPTDS,AM AC(10054); BIOCHEM ME Tf I-LIPIDS( 10056); BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD( 10064); 8 IOPHYS-GENE- RAL BIOPHYS TECH( 10504); BIQPMYS-BIOENGINEERING(* 10511); EXTERN EFF-TEMPERATURE( 10614); EXTERN EFF-C0LD( 106 1 6): EXTERN EFF-H0T(10618); ENZYMES-METHODS(*10804); MOVEMENT(121OO}: FOOD T ECH-PREP.PROCESSNG.STORAGE( 13532); TEMPERATURE -GE NL.ME T HS(2300 I); PLANT MORPHOL,EMBRYOL.ANATOMY(- 51000); PLANT PHYS10L-ENZYMES(*51518); PLANT PHYSIOL-APPARATU SES THOOS( 5 1524 ); HORTICULT-TROP FRUIT.NUT,PLANTAT(53004) Biosystemattc Codes: BROMELIACEAE(25235 ) 70071009 THE IMMOBILIZATION OF BRDMELAIN ON POLY VINYL CHLORIDE POWDER CHANG P-S; SHAW d-F OEP. CHEM.. TAIWAN PROV. KA0H5IUWG TEACH. COLL., KADHS1UNG. TAIWAN'. NATL SCI COUNC MON Language: CHINESE 8 (4). 1980. 313-322. Coden: KJIFKD The purified proteotytfc enzyme from pineapple stein Julco, bromelain, was covalently couplod to on Insoluble support, PVC [polyvinyl chloride] powder. In the preparation of Immobilized bromelain [used for food processing], the procodure Involved: controlled dertv11ze11 on of the PVC powder with e t hy 1 ened t am 1 ne or hex a me thy 1 ened lamina or 4 . 4'- d i am I nod ipheri- ylmethane In ethanol solutions to form alkylamlno or arylamlno derivatives. activation of the amino derivatives by various routes and enzyme at tachmont on t tie active suppor t in the various coupling times and pH values. The size of the currier. 1 he amount of activating reagent, the procedure for the activation of PVC and the time for coupling reaction affected the amount of enzyme immobilized and its relative activity. The maximal amount of bromelain 1 irnnob111 zed was 58 mg/g of PVC and the maximal relative activity was 49.57.. 1 tie optimal tempera turn. optimal pH, thermal stability and Km values of Ot.ALQG FlleS: OIOS1S Previews 77-83/Jan 0A7502;RRM2402 { Seo X ) (c. BIOSIS R&S 138428 J) User 3614 2 2074 70068637 DESIGN AND TESTING OF A MICRO LYSIMETCR FOR WETLAND RICE 0RY2A-SATIVA TOMAR V S: O'TOOLE 0 C P.O. BOX 933, MANILA, PHILIPPINES. AGRON J 72 (A). I960. 689-692. Coden: AGJOA Language: ENGLISH Assessment of water loss as transpiration and evapotransplratlon for each hour or for each day In the field (s difficult because the available methods are either very expensive or Inaccurate. This paper introduces a simple, sensitive and accurate microlysImeter for wetland rice (0. satIva L.) fields. The mlcrolysIraater was designed and tested to measure transpiration and evapotransp1rat1 on In wetland rice fields. It consists of a poIy-v1ny1-chI or 1de cylinder, sealed at the lower and end and connected to a water reservoir/manometer through flexible tubing. A constant water level Is maintained In the m1cro1ys1 meter with a Marlotte system and water loss from the reservoIr/manometer Is measured. Total water toss as evaporation from free water surface In the cylinder and transpiration Iron canopy was measured as evapotransplratlon. To measure transp1rat1 on. the cylinder was covered to stop evaporation from free water surface In the cylinder. The mtcrolysImeters were 1aboratory-ca1 I bra ted and compared In the field with large square tanks. Water use pattern as evapotransplratlon per unit land area was essentially the same with both the units. The m1cro1ys 1 me ter Is accurate even for time Intervals as short as 1 hour and can be fabricated locally. Descriptors: TRANSPIRATION EVAPO TRANSPIRATION Concept Codes: PLANT PHYSIOL-WATER RELATIONS(*51502); PLANT PHYSIOL - APPARATUS.ME THODS(51524); AGRONOMY-GRAIN CROPS(52504) ; SOIL SCI-GENL STUDS.METHS(*52801); SOIL SC I-PHYSICS.CHEMIST - RY(*52805) Blosystemattc Codes: GRAMINEAE(25305) (Occupation Safety and Health Administration). Room air concentratIons for the 12 degradation products for which TLV are assigned, based on overage values per cut, were no greater than 0.3% of accepted limits. Room air concentrations of DOA (d1octy1 adIpateJ are not determinable from available data, but present Information does not Indicate that exposure to 00A causes airway hyperreactivity. The coot rod. rather than the hot wire, is recommended as good Industrial hygiene practice, producing no apparent PVC degradation products, even though similar amounts of DOA are volatilized. Descriptors: 01 OCTYL AO I PATE THRESHOLD LIMIT VALUE MINIMAL DILUTION VENTILATION Concept Codes: GENL 8 IOL-INSTI TUT,ADMIN,LEG ISLN(00508): ECOLOGY-BIOCLIMATOL.BIDMETEORQL(07504); BIOCHEM STUO-GENERALt- 10060): BIOPHYS-BIOENGINEERING(10511): EXTERN EFF-HOT( 106 1 8 ) : PATHOLOGY-INFLAMMATN.INFLAM DIS(12508); FOOD TECH-MEAT.MEAT 8Y-PR00UCTS( 135 16): FOOD TECH-PREP.PROCESSNG.STORAGE(*13532 ) ; RESPIRATORY 5YST-PATHOLOGY(16006); TOXICOL-ANTIDOTES,PREVENT I - VE(22505); TOXI COL -ENVIRONMNTL.IN0USTR{*2 2506); TEMPERATURE-G- ENL.METHS(23001): IMMUNOL/IMMUNOCHEM- IMMUNOPATHOL(34 508); ALL- E RGY(35500): PUB HEALTH-ADMINISTR.STAT I ST ICS(37010); ENVIRON HEALTH-OCCUPATNL HEALTHt*37013); ENVIRON HEALTH-A IR.WATR.SL P0LLN(37015) 70067906 INDUSTRIAL HYGIENE EVALUATION OF THERMAL DEGRADATION PRODUCTS FROM POLY VINYL CHLORIDE FILM IN MEAT WRAPPING OPERATIONS COOK W A UNI V. MICH.. ANN ARBOR. MICH. 48109, USA. AM IND HYG ASSOC U Language: ENGLISH 4 1 (7). 1980. 508-512. Coden: AI HA A An Industrial hygiene evaluation Is presented concerning experimental data on thermal degradation products from hot-wire and cool-rod cutting of PVC [polyvinyl chloride] film used in meat-wrapp1ng operations. Room air concentrations of less than 0.2 ppm MCI and less than 0.05 ppm benzene can be maintained by a number of factors. Including minimal dilution ventilation. Estimates of room air concentrntIons of degradation products are presented using overage values of amounts produced per cut. The relation of these concentrations to TLV [threshold limit values) Is given, with methods of suggesting TLV for substances not 1Isted by ACGIH (American Conference of Governmental Industrial Hygienists) or OSHA 01 ALO CH e5: B10SIS Proviews 77-83/Jan BA7502 ; RRM2402 { Sea F I 1 70064539 MUTAGENIC ACTIVITY OF VINYL COMPOUNDS AND DERIVED EPOXIDES SIMMON V F; BADEN J M GENEX CORP., 6110 EXECUTIVE BLVO.. ROCKVILLE. MO. 20B52. USA . MUTAT RES 78 (3). 1980. 227-232. Language: ENGL ISH Coden: MUREA Man/ vinyl compounds. such as v1n/1 chloride and some Inhalational anesthetics, are mutagens. Ten vinyl compounds or derived epoxides, widely used In Industry, were assayed In' the Sa1mone11 a typhImurlum/mamma 11 an mlcrosome system. Three histidine-dependent S. typhlmurtum strains (TA 1535, TA 9B and TA 1O0) were used. Of the 10 compounds, 9-v1ny1 anthracene. v1ny1carbazo1e. 3-vIny1 - 7-oxab1 eye 1o{4. 1.O)heptane 3-epoxyethy 1 -7-oxab1 eye 1o[4. 1.O]-heptane were mutagenic. and The the overall genotoxlclty of vinyl compounds and epoxides Is confirmed; these compounds should be carefully screened for mutagenic/carcinogenic effects. [The other compounds screened for mutagenicity wore 2-viny1 naphtha 1 one, 2-v1ny1b(phony 1. 2-vinylpyrldlne) 4 -v1ny1 pyridine, 5-vtnyl-2-norbornene and N-V(ny1-2-pyrrol id!none. Human applicability Is Implied], Descriptors: SALMONELLA-TYPHIMURIUM TA-98 TA-IOO TA-1535 STRAINS MAMMALIAN MICROSOME HUMAN INHALATIONAL ANESTHETIC VINYL CHLORIDE 2 VINYL NAPHTHALENE 9 VINYL ANTHRACENE 4 VINYL BI PHENYL 2 VINYL PYRIDINE 4 VINYL PYRIDINE VINYL CARBAZOLE 5 VINYL-2 NORBORNENE N VINYL-2 PYRROL IDINONE 3 VINYL-7-OXA BI CYCLO 4.1.0 HEPTANE 3 EPOXYETHYL-7-OXA BI CYCLO-4.1.0 HEPTANE GENO TOXICITY CARCINOGENICITY INDUSTRIAL CHEMICAL Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); CYTOLOGY/CY- TOCHEM-HUMAN(02508 ) ; GENETICS/CYTOGENET-ANIMAL(03506); GENETI CS/C YTOGENET-HUMAN(*03508); BIQCHEM STUD-GENERAL(10060); METABOLISM-NUCL ACD,PURINS,PYRIM(* 13014); RESPIRATORY SYST-GE- NL STUD,METHSt16001); PHARMACOL-NEUROPHARMACOLOGY(22024); ROUTES OF ' IMMUNIZ.INFECT,THERAPC22lOO); TOXI COL-GENL/EXP STUDS,METHSt *22501 ) ; TOXICOL-PHARMACOLOGICAL{22504 ): TOXICOL-- ENVIRONMNTL,INDUSTRt*22506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS- (24007); BACTERIAL AND VIRAL GENET ICS(31500); MICROBIOLOG APPARAT.ME THS,MED I A{3 2000); TISS CULTURE-APPARAT.METHS,MED IA{ - 32500); IN VITRO STUDS-CELLULR,SUBCELL(32G00); HE A LTH-OCCUPA TNL HEALTH(37013) ENVIRON Blosystematlc Codes: ENTEROBACTERIACEAE(04810); MAMMA LI A -UN- SPECIFIED AND EXTINCT(B5700); H0MIN1DAE(86215) (c. BIOSIS 1982) (I R&S 138429 36 14 25J an03 2075 marrow chromosomes were analyzed for Induced chromosono aberrations and slstcr-chroraatId-exchanges (SCE) 26 h after beginning of exposure. The frequency of VC-induced chromosome aberrations and SCE both depend on dose and length of exposure. The highest measured effects were 33.25 SCE/cell after an exposure to 2.5% VC for 24 h and 25.7% mctapliases with aberrations, when exposed to 5% VC for 24 h. Descriptors; HAMSTER BONE MARROW SISTER CHROMATID EXCHANGE METAPHASE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL{*02506); GENETICS/C YTOGENET -ANIMALt*03506); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUO-NUCL ACO.PURNS.PYRM( 10062); METABOLISM-GENL STUD,METAB PATHW( 13002): METABOLISM-NUCL ' ACD.PURINS.PYRIM( 13014); BLOOD/BODY FLDS-GENL STUDS.METHS{15001): BLOOD/BODY FLDS-BLOOD.LYMPH STUO(15002); BLOOD/BOOY FLOS-BLOQD CELL STUOS( 15004); BLOOD/BODY FLOS-8LD.LYM.RES PATH(* 15006); BLOOO/BODY FLDS-LYMPHAT TISS.RES{15008); RESPIRATORY SY ST-GENL STUD.METHS( 16001 ); BONE.JNTS.FASC,CONN/AO IP-GENL( 18 - 001); BONE,JNTS.F ASC.CONN/AOIP-PATHOL( 18006) ; ROUTES OF IMMUNIZ.INFECT,THRAP(22lOO): TOXI COL -E NV1RONMN T L,INDUSTR{*22506); ENVIRON HEALTH-AIR,WATR . - SL POLLN(37015) Blosystematlc Codes; CRICETJOAE(86310) 70064463 VINYL CHLORIDE AN EXAMPLE FOR EVALUATING MUTAGENIC EFFECTS IN MAMMALS IN-VIVO AFTER EXPOSURE TO INHALATION BASLER A; ROEHRBORN G INST. HUMANGENET. ANTHROPOL. UNIV., UNIVERSITAETSSTR. 1.GEBAEUDE 23. 12. 0-4000 DUESSELOORF 1. W. GER. ARCH TOXICOL 45 (1). 1980. 1-8. Coden: ARTOO Language: ENGL ISH As part of a program of 1nves tIga t1ons on the mutagenic effects In mammals in vivo after Inhalation of environmental chern teals, the effects of the 1 ndus trial compound vinyl chloride (VC) were analyzed. Chinese hamsters wore exposed to 1.25, 2.5 or 5% (vol/vol) VC In air for 6, 12 or 24 h. Bono DIALOG F11e5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See F11e55) {c. BIOSIS 1982 R&s 138430 er 361 A 25Jan8 3 2076 70061552 DETERMINATION BY ELECTRON CAPTURE GAS CHROMATOGRAPHY OF MONO-2 ETHYLHEXYL PHTHALATE AND DI-2 ETHYLHEXYL PHTHALATE IN INTRA VENOUS SOLUTIONS STORED IN POLY VINYL CHLORIDE BAGS ARB IN A; OSTELIUS J RES. DEP. . AGO LAKEMEOEL AB, BOX 3026, S- 171 03 SOLNA 3, SWED . J CHROMATOGR 193 (3). 1980. 405-4 12. Coden: JOCRA Language: ENGLISH D1(2-ethylhexyl) phthalate (DEHP) Is used as a plasticizer In polytvlnyl chloride) (PVC), which is frequently used In medical items such as bags for blood transfusions and !.v. solutions. A gas chromatograph 1c method was developed for the simultaneous determination of mono- and d1(2-e thy1hexyt) phthalate (MEHP and DEHP), The compounds were extracted with methylene chloride at pH 2.5 and the monoester was alkylated to t lie hexyl derivative by solid-11quId phase transfer catalysis In methyl ethyl-ketone. Ouant11a 11 on was effected by electron-capture gas chromatography. The sensitivity limits of the method are 4 .mu.g/1 of bEHP and 1 .mu.g/1 of MEHP. The relative SD are 4.2*/. for DEHP (31 . mu. g/1 ) and 3.7% for MEHP (27 ,mu.g/1) (n = 10). Descriptors: PLASTICIZER BLOOD TRANSFUSION BAGS Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES(10010); BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUD-GENERAL{10060): BIOPHYS-GENERAL BIOPHYS TECH( 10504); MOVEMENT( 12 100): CARD I OVA SC SYST-GENL STUDS,METHS( 14501 ): BL0DD/B00Y FLDS-GENL STUOS,METHS(* 15001): ROUTES OF IMMUNIZ.INFECI,THERAP(22100): TOXICOL-GENL/EXP STUDS.METHS(*22501) 70061522 TRANSPORT CONSIDERATIONS OF POTENTIAL MIGRANTS FROM FOOD PACKAGING MATERIALS GILBERT S G; MILTZ J: GIACIN d R FOOD SCI. DEP., COOK CDLL.. RUTGERS STATE UNIV.. P.O. BOX 231. MEW BRUNSWICK, N.J. 08903. USA. J FOOO PROCESS PRESERV 4 (1-2). 1980. 27-50. Coden: JFPPD Language: ENGLISH Migration from polymeric packaging materials to contained foods Is essentially a desorption process 1nvo1vlng low MW species in a polymeric matrix. Such desorption can affect Intrinsic quality and safety of Ingested packaged food. A legalistic problem also exists because of present regulations of zero tolerance where a possible migrant is a potential carcinogen. The precise elucidation of desorption, at extremely low levels of Initial migrant concentrat1 on, has become a major Issue. but desorption at such levels has not been adequate!y studied. Sorptlon/desorptIon studies conducted with food simulating solvents and foods In classical phase distribution systems show marked concentration dependence for certain poly (vinyl chloride) resins. The thermodynamic relations between selected monomer/polymer systems were futher studled by Inverse phase gas chromatography for poly (vinyl chloride) and poly (aery 1 on 11rtle) and some of Its copolymers. for transpor t. Descriptors: DESORPTION MOLECULAR WEIGHT POLYMER CARCINOGEN CHROMATOGRAPHY Concept Codes: COMPARATIVE BIOCHEM-GENL STUDIES!lOO10): BIOCHEM STUD'GENERAL{* 10060): BIOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHY S-MOL ECUL PROP.MACROMOLE C( t0506); MOVEMENT - (12100): FOOD TECH-GENL STUDS,METHS(* 13502); FOOD TECH-EVALNS PHYS.CHEM PROPS(* 13530) ; FOOD TECH-PREP.PROCESSNG,STORAGE( * 13- 532): TOXICOL-FOOO.RES IDS.ADDIT,PRESRV{*22 502); NEOPLSMS/NEOPL AGNTS-CARCINOGENS!*24007) 70061083 ANAEROBIC TOXICITY EVALUATION BY BATCH AND SEMI CONTINUOUS ASSAYS STUCKEY D C; OWEN W F; MCCARTY P L: PARKIN G F CIV. ENG. DEP., STANFORD UNIV.. STANFORD, CALIF. USA . J WATER POLLUT CONTROL FED Coden: JWPFA 52 (4). 1980. 720-729. Language: ENGL ISH The results of a sImple batch assay techn1que (anaerobic toxicity assay) for evaluating toxicity thresholds (in anaerobic sludge digestion systems] are presented for 4 chem(cats (methylene chloride, vinyl acetate, ethylene dlchlorlde and vinyl chloride) and are compared with those obtained from a semi-coatInuous assay. The batch method 1nvo1ved the 1nocu1 a t(on of the chemleal together with anaerob 1c seed, nutrient med1 a and ethanol Into a serum bottle under anaerobic conditions. Sem1-contInuous studies were carried out using 1.5 1 digesters with a detention time of 15 days. Toxicity thresholds for batch and semi-continuous assays are similar unless acclimation, biodegradation or volatilization occurs. When these occur the batch assay provides a conservative estimate of the threshold. Batch assays are quick, cheap, flexible and accurate. Semi-cont1nuous assays are slow and expensIve, but give a more useful assessment of toxicity when acclimation, biodegradation or volatilization occurs. Descriptors: ANAEROBIC SLUDGE DIGESTION SYSTEM METHYLENE CHLORIDE VINYL ACETATE ETHYLENE 01 CHLORIDE VINYL CHLORIDE ACCLIMATION BIO DEGRADATION VOLATILIZATION Concept Codes: ECOLOGY -WATR RESRCH.FISHERY BI0L(07517 ); BIQCHEM-GASES(1OO12): BIOCHEM STUD-GENERAL(10060); BIOPHYS-BI- OENGINEERING(* 1051t); TOXICOL-GENL/EXP STUDS,METHS(22 50 1 ) : TOXICOL-ENVIRONMNTL.INOUST R(*22506); MICROORGANISMS-GENL.MIXED,UNSPEC(29500); MICROBIOLOG APPARAT,- ME THS.MED I A{3 2000); ENVIRON HEALTH-SEWG 0 ISP.SANITAR(* 370 1 4 ) ; ENVIRON HEALTH-AIR,WATR.SL POLLN(37015); FQOO/INDUS MICRO-BIODEGRAD,DETER(39006); FOOD/INDUS MICRO-GENL.MI SC STUDSt *39008) Blosystemat1c Codes: MICROORGANISMS-UNSPECIFI ED(010O0) DIALuWrlleS: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See Flle55) te. BIOSIS 1981 R&S 138431 Iser 3614 25jan83 2077 70058053 PHARMACQ KINETICS OF VINYL CHLORIDE IN THE RHESUS MONKEY BUCHTER A; FILSER J G; PETER H; BOLT H M INST. POLIKLIN. ARB. SOZIALMED., UNIV. KOE1.N, JOSEF -STELZMANN-STR. 9. D-5GOOKOELN 41. W. GER. TOXICOL LETT (AMST) Language: ENGLISH 6 (t). 1980. 33-36. Coden: TOLEO The me tabolie elimination of vinyl chloride carcinogen] In Rhesus monkeys Is a dose-dependent, f VC. a sa tii'rab 1 e process, as In rats. Below 200-300 ppm of VC In atmosphere, elimination obeys a Ist-order law; the clearance rate Is much closer to that found In man than the vatues for rats, mice and gprblls. The maximal velocity of metabolic elimination of VC at high concentrattons In Rhesus monkeys Is only about 1/2 that of rats when related to kilograms body weight. Rhesus monkeys evidently mimic the quantitative aspects of VC motabolism better than do rats or mice. Descriptors: RAT MOUSE GERBIL HUMAN CARCINOGEN Concept Codes: B1DCHEM STUD-GENERAL(10060); PHYSIOLOGY-COMP ARATIVE ( 1 2003 ) ; PATHOLOGY-COMPARATIVE]12503); METABOLISM-GENL STUD.METAB PATItW] * i3002) ; TOXI COL-GENL/EXP S TIJOS , ME THS ( * 22501 ) ; TOXI COL -ENVIRONMNTL,INDUST R(2 2 506); NEOPLSMS/NEOPL AGNTS-CA- &C I NOGENS ( * 2 4007 ) ; ENV I RON HE A LTH-A I R . W ATR . S L P0LLNO70I5) B tosysternat1c Codes: CERCOPITHECIOAE(8 6205); HOMINIDAE(8 62t- 5); CRICETIDAE(86310); MURIDAE(86375) 70056329 RADIOLOGICAL OBSERVATIONS DURING TRANS PYLORIC TUBE FEEDING IN INFANTS OF LOW BIRTH WEIGHT MERTEN 0 F: MUMFORD L; FILSTON H C; BRUMLEY G W JR; EFFMANN E L: GROSSMAN H OUKE UNIV. MEO. CENT., BOX 3834, DURHAM. N.C. 27710, USA. RADIOLOGY 136 {!). 1980. Language: ENGLISH 67-75. Coden: RADLA Perforation of the duodenum Is a serious complication of transpylorlc tube feeding in Infants of low birth weight. Polyvinyl chloride and (less commonly) silicone tubes are implicated. Altered radiographic configuration of the tube in the region of the superior or inferior flexure associated with cl fnlcal deterioration, pneumoperitoneum. peritonitis or a retroper 1tonea1 fistula is diagnostic of duodena! perforation. Conf1guration of the tube may vary during uncomp 1 Ica ted transpylorlc alimentation and Is frequently Incompatible with the oxpoctod anatomical course. Contrast examination may demonstrate normal anatomy or mobility of the distal duodenal loop as an adaptation to rigidity of the tube. Possibility of perforation appears to be Increased at or adjacent to the flexures. ` Descriptors: HUMAN DUODENAL PERFORATION PERITONITIS PNEUMO PERITONEUM RETROPERITONEAL FISTULA POLY VINYL CHLORIDE SILICONE Concept Codes: PHOTOGRAPHY-METHS.MATLS.APPARAT(01012) ; RADI AT ION BIOL-RADTN, ISOTOP TECH(06504 ); B1OCHEM-GASES( 10012}: BIOCHEM STUO-GENERAL( 10060): ANATOMY/HISTOL-RAD IOLDGIC(* 1 1 106) ; CHOROATE BODY REGNS- ABDOMEN{ 11314); MOVEMENT( 12100): PATHOLOGY-DIAGNOSTIC{ 12504); PATHOLOGY - INFLAMMATN.INFLAM 01 Si 12500); PATHOLOGY-NECROSIS{ 12510) ; NUTRITI ON-GENL.NUTR STATUS.METHSt* 13202); DIGESTIVE SYST-GENL STUDS.METHS( 14001>: DIGESTIVE SYST-PATHOLOGY(*14006); COELOM MEMBRANES.MESENTERIE- S, ETC( 18200); PEDtATRICS(*25000); OEVELOPMNTL BIOL-PATHOLOGIC- AL(*25503) B losystemat1c Codes; HOMINIOAE(86215); BIOSIS INTERNAL USE(97000) 70054660 MIGRATION OF INDIRECT FOOD ADDITIVES A PHYSICAL CHEMICAL APPROACH KASHTOCK M E; GIACIN J R; GILBERT S G DIV. CHEM. PHYS. . US FOOD ORUG ADM. WASHINGTON. D.C. 20204, USA . 200 ST . S.W. J FOOD SCI 45(4). 1980. 1008-1011. Coden: JFOSA Language; ENGLISH Active site binding of vinyl chloride monomer by polyvinyl chloride was demonstrated In 2 of 3 unplasticized resins, by equilibrium partitioning studies. The magnitude of this effect was less than what was observed In previous studies. The potential for active site binding to be a limiting factor for the migration of Indirect food additives may depend upon chemical and morphological features of the particular resin used to manufacture the food contact article. Inverse phase gas-so I Id chroma tographic studies have also shown active site binding In the unp1 ast1c1 zed resin sample studied by this method. Simple dissolution was the predominant mode of monomer/potymer Interaction for the plasticized counterpart of this resin. These studies showed the potential for obtaining reliable data for Interaction of po1ymer resins with indirect food additive type mol ecules by this more quickly performed technique. Descriptors; RESINS ACTIVE SITE BINDING CHROMATOGRAPHY Concept Codes: COMPARATIVE BIDCHEM-GENL STIJOlES(10O10): BIOCHEM METH-GENERAL(10050); BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-MOLECUL PROP,MACROMOLEC( 10506); MOVEMENT( 12100) ; FOOD T E CH-GENL STUDS.METHS(13502); FOOD TECH-EVALNS PHYS.CHEM PROPS(* 13530); FOOD TECH-PREP.PROCESSNG.STORAGE( 13532 ) ; TOXI COL-F000 . RESI OS.ADD!T.PRE SRV(*22502) DI ALO le5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See F1 ) (c. BIOSIS 1982 ) R&S 138432 3614 25 J an83 2078 70054657 DETERMINATION OF OLIGOMERS IN VINYL CHLORIDE POLYMERS BY STERIC EXCLUSION CHROMATOGRAPHY GILBERT d: SHEPHERD M J; WALLWORK M A FOOD SCI. Drv. . MINI ST. AGRIC. FISH. FOOD. HALDIN HOUSE. OUEEN ST.. NORWICH NR2 4 SX. NORFOLK. ENGL., UK. J CHROMATOGR t93 (2). 1980. 235-242. Coden: dOCRA Language: ENGLISH Low MW materials were loslated from polyfvinyl chloride) resins by diethyl ether Soxhtet extraction and these were subsequently fractionated on a combination of sterlc exclusion columns. Estimations of oligomer levels In the Isolated MW fractions were made on the basis of gravimetric measurements and micro Cl determ 1nat1ons. The presence fn each fraction of a large number of species was demonstrated by high-performance sterlc exclusion chromatography and mass spectrometry was employed for attempted characterization. [The quantification of constituents d1scussed.] In plastic food packaging materials Is Descriptors: PLASTIC FOOD .PACKAGING MASS SPECTROMETRY Concept Codes: COMPARATIVE BIQCHEM-GENL STUDIES( 100 10); BIOCHEM METII-GENERAL(* 10050); BI0CHEM . STUD-GENERAL( 10060); BIOPHYS-GENERAL 8I0PMYS TECH( 10504); MOVEMENT( 12lOO); FOOD TECH-GENL STUOS.METHS{ 1 3502); FOOD TECH-PREP.PROCESSNG.STORAG ES 13532) ; TOXICOL-FOOD.RES IDS,ADDIT.PRESRV(*2 2502) 70054080 POLY VINYL CHLORIDE WORK BOOTS IN THE MANAGEMENT OF SHOE DERMATITIS IN INDUSTRIAL WORKERS MATHIAS C G T; MAI BACH H I DEP. DERMATOL.. UNIV. CALIF. MED. CENT.. ROOM 342-A, SAN FRANCISCO, CALIF. 94143, USA. CONTACT DERMATITIS 5 (4). 1979 (RECD. 1900). 249-250. Coden: CODED Language: ENGLISH A sugar refinery worker developed allergic contact dermatitis of his feet secondary to rubber accelerators In his work boots. The dermatitis resolved when polyvinyl chloride work boots were substituted. The importance of controlling hyperh1dros1s In the management of foot dermatitis In workers Is d1scussed. Descriptors: SUGAR REFINERY WORKER HYPER HIDROSIS ALLERGIC CONTACT DERMATITIS RUBBER ACCELERATOR Concept Codes: CHOROATE BODY REGNS-EXTREMITIES(II318); PATHOLOGY-INFLAMMATN.INFLAM 015( 12508); FOOD TECK-SUGAR( 13524) ; URIN SYST/EXT SECR-PATHOLO&Y(* 15506); INTEGUMENT SYST-PATHOLOGY(* 18 506 ) : TOXI COL -ENVIRONMNTL.INDUSTR(*22 506); IMMUNOL/IMMUNOCHEM- IMMUNOPATHOL(3 4 500); ALLERGY(* 35500); ENVI RON HEALTH-OCCURATNL HEALTH(* 37013) B1osystemattc Codes: HOMINIOAE(86215) NORPOTH K; GOTTSCHALK D; GOTTSCHALK I; WITTING U; THOMAS H; EICHNER 0; SCHMIDT E H INST. S T AtJB LUNGENF ORSCM. AHBEITSMEO., UNIV. MUENSTER. WESTRING 10. 0-4400 MUENSTER, W. GER. J CANCER RES CLIN ONCOL 97 (t). 1980. 41-50. Coden: JCROD Language: ENGLISH Male Wlstar rats (240-320 g body wt) were partially (2/3) hepatectom1 zed and Immediately thereafter exposed to inhalation of vinyl chloride monomer (VCM) over 28 h at concentrations of O, 50, 125 and 500 ppm. Following partial hepatectomy, rats of 130-150 g were infused by the caudal vein over 28 h with As203 (AT) at concentrations of O. 1. 2 and 10 mg/ml. The total volume of the Infusion was 16.8 ml. Following treatment, the liver was removed and proliferative activity In the tissue was studied. With preparations from VCM-treated animals. Investigations were made of the mitotic. Index (histologically), the 3H-thym1d1ne Index (autorad 1ograph lea 1 1 - y) and the Incorporation of 3H-thym1dfne in DNA (using liquid-scintillation counting). ONA synthesis In nuclei of these tissues was studied by 1mpu1se-cytophotometry determining the proportions of cells In S-phase to those in G1. Incorporation of 3H-thymld1ne and mitotic activity was also determined using tissue from AT- treated animals. The tissue alkaline phosphatase activities in liver preparations from VCM- and AT-treated animals were also measured. In all measured parameters. an Increase was observed over values found 1 n cont ro!s and those Increases were dose-re 1 a ted. Adm1n1stra11 on of VCM or AT leads to stimulation of cell proliferation (n regenerating rat liver. The increase of alkaline phosphatase activity could not be referred to preferential effects of VCM and AT on endothelial cells. As shown by hIstochem1caI Investigations. the alkaline phosphatase activity was localized mainly In bile-duct canal icult, not In sinusoids. (VCM and AT are carcinogens.) Descrfptors: CARCINOGEN ALKALINE PHOSPHATASE DNA SYNTHESIS Concept Codes: PHOTOGRAPHY-METHS,MATLS.APPARAT(0 10 1 2 ) ; MICROSCOPY-CYTOLOG.CYTGCHEM TECH(01054); MICROSCOPY-HISTOL,HI - STOCHEM TECM(01056); CYTOLOGY/CYTOCKEM-ANIMAL(*02506 ) ; RADIATION BIOL-RADTN.ISOTOP TECH(06504); BIOCHEM STUD-GENERAL - (10060): BIOCHEM STUD-NUCL ACD.PURNS.PYRM(I0062): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO AC0( 1006 4); MINERALS(10069) ; ENZYMES-PHYSIOLOGICAL STUDIES( 10808); ANA TOMY/HISTOL-EXPERIME- NtAL( 11104); ANATOMY/HISTOL-RADI0L0GIC( 11106); ANA!OMY/HI5TOL - -REGEN.TRANSPLANT(* 11107); METABOLISM-PROTNS,PEPTOS.AM ACDS( 1 - 3012): DIGESTIVE SYST-GENL STUDS.METHS(1400 I ): DIGESTIVE SYST-PATHDLOGY(* 14006); CARDIOVASC SYST-GENL STUDS.METH5( 1450- 1); RESPIRATORY SYST-GENL STUD,METHS(16001); ROUTES OF IMMUNIZ.INFECT,IHERAP(22100); TOX I COL-GENL/EXP STUDS.ME!HS( *2 - 2501): NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007) B I osystematIc Codes: MUR I DAE(86375) 70052153 INFLUENCE OF VINYL CHLORIDE MONOMER AND ARSENIC TRI OXIDE ON RAT LIVER CELL PROLIFERATION AFTER PARTIAL MCPATECTOMY DIALOG" 1 e5: 8I0SI5 Previews 77-03/jan BA7502;RRM2402(See Ftle55) (c. B10SIS 1982) (Item 295 of R&S 138433 2079 70052 127 EXAMINATION OF WORKERS IN POLYMERIZATION PROCESS OF VINYL CHLORIDE MONOMER HASEGAWA H; SATO M; OKONOGI K: SHIMAOKA A; TSURUTA H NATL. INST. I NO . HEALTH, NAGAO 6-CHOME, TAMA. KAWASAKI. KANAGAWA 213. JPN . IND HEALTH 17 (3). 1979 (RECO. 1980). 153-186. Coden: INHEA Language: ENGLISH The results of health examinations of VCM [vinyl chloride monomer) workers In 1975 or 1976 are described. All workers examined were healthy, and liver or spleen enlargement was not observed. Worker blood catalase activity was seriously significant for VCM exposure. The decrease of blood catalase activity In rats exposed to VCM corresponds to the concentration of VCM. The decrease of catalase activity In man was significant when the activity value was < 90)i. When the activity value was In normal range, the difference between the value and that obtained by later tests was cons Idered. Diastolic blood pressure rose In some cases, but the rise could be explained by the results on catalase activity and blood platelets, etc. Although the activity of .gamma.-GTP [.gammag1utamyI transpoptIdase) was an Important factor for discerning the Influence of VCM, It should be carefully treated by taking Into account the other tests . results when the Increase Is sma11. Measurement of serum 1 Ip Ids such as tr1glycer ides and free fatty acids, etc. should be considered as a co-factor with the synthetic result of . gamma.-GTP., blood platelets, reticulocytes, blood pressure and catalase activity. As the result of tracing VCM workers for .apprx. 1 yr who were exposed to VCM of 0.2 ppm or less for at least 1 yr. It was assumed that serum proteins and surum bilirubin were scarcely Influenced. Measurement of aspartate transaminase. alanine transaminase and alkaline phosphatase may be necessary for finding soma disordered states of the liver, but not as serious for finding VCM Influence In the 1st screening. As a screening test for VCM workers, blood catalase activity, .gamma.-GTP, blood platelets, reticulocytes and blood pressure should be studied, and the results of the tests should be considered together. Since .gamma.-GTP value increases by dally drinking and decreases fairly quickly by discontinuation of drinking, the test must be carried out In an accustomed life-style, and the result shouId be carefully considered by making reference to the amount of drink ir the worker drank habitually. The amount of VCM in the blood of workers was several ppb, and In 1976 It was less than that In 19 75. In some workers. a I though the metabolic speed of VCM 1n the body was considered to be rapid. VCM In the blood was detected after 4 8 h apart from VCM works. care 1 nogen, J [VCM Is a Descriptors: RAT CARCINOGEN LIVER PLATELFIS RETICULOCYTES BLOOD PRESSURE CATALASE GAMMA GLUTAMYL TRANS PEPTIDASE ASPARTATE TRANS AMINASE ALANINE TRANS AMINASE ALKALINE PHOSPHATASE SERUM LIPIDS DRINKING Concept Codes: BEHAVIOR BIOL-HUMAN BEHAVIOR(07004); CLIN BIOCHEM-GENL STUDIES(* 10006) ; BIOCHEM STUD-GENERAL( 10060 ) ; BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACD(10064); BIOCHEM STUD-PDRPHYRNS.BILE PIGM(100651: BIOCHEM STUD-LIPI0S<10066): EN7. YMES- PHY SI0I.0G1CAL ST UD 1 E S ( 10808 ) : ME T ABDL I SM - G F HI. STUD,ME T AB PA T HW( * 13002); METABOL1SM-LIPIDS( 13006); METABOLIS- M-PROTNS.PEPTDS.AM ACDS(13012); METABOLISM-PORPMYRINS,BILE PIGMNf 13013): CARDIDVASC SYST-PHYSIOL.BI0CHEM( M504 ) : BLQQD/B00Y FLDS-BL000.LYMPH STUD(150O2); BLOOD/BODY FLOS-BLOOD CELL STUDSt15004>: BLOOD/BOOY FLDS-BLD,LYM,RES PATH(55006); PSYCHIATRY-ADDICTI0N(INC SMOKNG)(21004); TOXI COL-GENL/EXP STUOS,METHS(*22501); NEDpLsmS/NEOPL AGNTS-CARC1 NOGENS(24007): ENVIRON HE AL TH-OCCUPATNL HEALTH(*37013) Blosystemat tc Codes: HOM1HIDAE(86215); MURIDAE{06375) DIALOG F11e5: BIOSIS Previews 77-83/Jan BA7502 ; RRM2402 ( See F i 1 e55 ) (c. BIOSIS 1982) (I tern R&S 138434 25J an83 2080 70049504 EMBRYO TOXIC EFFECTS OF DI-2 ETHYLHEXYL PUT) IALATE ANO DI-N BUTYL PHTHALATE IN MICE SHI OTA K; CHOU M J; NISHIMURA H DEP. ANAT., FAC. MEO., KYOTO UNIV,, KYOTO 606. JPN. ENVIRON RES 22 (1). 1980. 245-253. Coden: ENVRA Language: ENGLISH Two major compounds of PVC [polyvinyl chloride) plasticizers, d1-2-ethy 1hexy1 phthalate (DEHP) and dl-n-butyl phthalate (OBP). were mi.xed with food at levels of 0.05, 0.1. 0.2, 0.4 and 1.0 wt% and given to pregnant mice of ICR-JCL stra In throughout gestation. Treatment with 0.2, 0.4 and 1.0'/. DEHP and 1.0/. DBP resulted In decreased maternal weight gain and Increased resorptIon rate. All of the Implanted ova died In utero at 0.4 and 1.0% level of DEHP, The malformation rate In term fetuses Increased at 0.2% level of DEHP and 1.0% level of DBP, the difference f rom the control group being at the borderline level of significance. The major malformations observed In the treated groups were neura1 tube defects (exencephaly and spina bifida). suggesting that the phthallc acid esters [PAE] could Interfere with the closure of neuropores In developing embryos. Treatment with the compounds caused Intrauterine growth rotnrdatlon and delayed ossification with an apparently dose-related response pattern. These results Indicate that DEHP and DBP at a high dose level could be embryotoxic and possibly teratogenic to mice. The maximum no-effect love) of the PAE on mouse fetuses was 70 mg/kg per day, which Is far higher than the estimated human current Intake from the environment. Descriptors: HUMAN COMPARISON POLY VINYL CHLORIDE PLASTICIZER NEURAL TUBE DEFECT INTRA UTERINE GROWTH RETARDATION TERATOGENESIS Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES( lO010): BIOCHEM 5 TUD-GENERAL( lOOGO): PATHOLOGY-GENERAL SIUDIES( 12502); PATHOLOGY-COMPARATIVE( 12503); METABOLISM-GENL STUD,ME T AB P A THW( 13002); REPRODUCT SYST-GENL STUDS,METHS( 16501 ): DENTAL/ORAL BIOL-GENL STUD.METHS(19001); NERVOUS SYST-GENL STUDS,METHS(20501 ) : NERVOUS SYST-PATHOLOGY(*20506); ROUTES OF IMMUNIZ.INFECT,THERAP(221OO); TOXICOL-GENL/EXP STUDS.METHS{*2- 2501): TOXI COL-ENVIRONMNTL,INDUSTR(22506): OEVELOPMNTL BIOL-PATHOLOGICAL(*25 503): DEVELOPMNTL BIOL-EXPERIMENTAL( *255- 04); DEVELOPMNTL BIOL-GEN MORPHGENSIS(2550B); OEVELOPMNTL BIOL-DESCRIP TERAT0L(25552); DEVELOPMNTL BIOL-EXPER TERATOH*25554); ENV1 RON HEALTH-AIR.WATR.SL P0LLN(37015) B tosystema11c Codes: HOMINIDAE(86215); MUR I DAE(063 7 5) m1croscopy [SEM] using latex replicas. The latex replica was composed of a blend of vinyl chloride latexes using a plasticized vinyl chloride copolymer with a vinyl chloride copolymer. The polymerized latex produced a cast of the pulmonary arterial vascular tree, Including the capillary patterns, which freely anastomose, thereby draining blood into pu1monary velnules and veins. Latex was injected via a gravity flow system modified from Its earlier application In guinea pig lungs. Apparently normal lungs from 2 recently deceased humans (dead for 5-6 h and held In refrlgeratlon) were perfused with heparinized Ringer's solution and subsequently Injected with latex. Resulting latex casts of the cap 1 1larles revealed a 3-d I mens 1ona1 network arranged In Irregular vascular rings or ovals. This pattern was most conspicuous In deep and Intermediate bronchopulmonary segmental areas. Subpleural capillaries produced casts that often terminated blindly, as observed with stereo SEM, suggesting that these vessels may tend to form thrombi more easily compared to capillaries from other regions of lung alveoli. Pulmonary arteriolar replicas contained Indentations representing endo thellal coll nuclei. Capillary replicas projected ova 1 evag1na t1ons that may represent discrete loci or capillary mural a t t eriua t ions. Descriptors: GUINEA-PIG APICAL BRONCHO PULMONARY SEGMENT ENDOTHELIAL CELL THROMBUS Concept Codes: ELECTRON MICROSCOPY(01056); CYTOLOGY/CYTOCHE- M-HUMAN(*025081; BIOCHEM STUD-GENERAL(10060); BIOCHEM STUO-CARBOHYDR.(10068); EXTERN EFF-COLO( 10616): ANATOMY/HISTO - L-MICRO.ULTRAMICRSC( 1 1 108): CHOROATE BODY REGNS-THORAX( 1 1 3t2 ) ; PATHOLOGY-NECROSIS(12510): CARDIOVASC SYST-GENL STUDS,METHS{ 14501 >: CAROIOVASC SYST-ANATOMY{* 14502 ) : CAROIOV- ASC SYST-BLD VESS PATHOL(* 14508); BLOOD/BOOY FLOS-BLOOD , LYMPH STUD{* 15002); RESPIRATORY SYST-GENL STUD,METHS(* 16001) : RESPIRATORY SYST-ANATOMY{*16002); RESPIRATORY SYST-PATHOLOGY(- *16006); COELOM MEMBRANES,MESENTERIES,ETC(18200); TEMPERATURE- -GENL.METHS(23001): TEMPERATURE-HYPO.HYPERTHERM[A(23006) B iosystemat1c Codes: HOMINIDAEt86215); CAVI IOAE(86300) 70048064 SCANNING ELECTRON MICROSCOPIC EXAMINATION OF HUMAN PULMONARY CAPILLARIES USING A LATEX REPLICATION METHOD KENDALL M W; F.ISSMANN E DEP. ANAT., SCH. MED. SCI.. UNIV. NEV., RLNO, NEV. B95&7. USA . ANAT RFC 196 (3). 19B0. 275-204. Coden: ANREA Language: ENGL ISH Human pulmonary microvasculature from the apical bronchopulmonary segment was studied hv sr;mnlnn plprtrnn DIAL! kl!e5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See FI 700-17854 EXPOSURE OF PATIENTS TO ETHYLENE OXIDE DURING CAROIO PULMONARY BYPASS USING GAS STERILIZED PUMP COMPONENTS LINDOP C R; WILLCOX T W; MCKEGG P M; HARRIS E A CLIN. PHYSIOL. DEP.. GREEN LANE HOSP.. AUCKLAND 3. N.Z. J THORAC CARD1DVASC SURG JTCSA 79 (6). 1980. 045-850. Codenr Language: ENGLISH Ethylene oxide (EO), absorbed by polyvinyl chloride (PVC) and rubber components of the cardiopulmonary bypass {CPB) circuit during sterilization. Is subsequently eluted by the circulating blood-prime mixture and enters the patient. The amoun t of ED available for elution Is dlmlnlshed by 1ncrensIng the airing period of the tubing after sterilization, but It Is still appreciable after 72 h airing. When tubing Is used after 24 h airing, the amount of EO which enters the patient during 90 min of CPB Is probably at least 70 mg. During the first few hours after CPB, the amount of EO recoverable from the patient's blood rapidly diminishes, probably because of the binding of EO In Irreversible chemical combination. Descriptors: BLOOD POLY VINYL CHLORIDE Concept Codes: CLIN BIOCHEM-GENL STUD IES( 1000G)r COMPARATIVE BIOCHEM-GENL STUD 1ES(10010); BIOCHEM STUD-GENERAL( 10060): ANATOMY/HISTOL - SURGERY(11 105): METABOLISM-GENL STUD.METAB PATHW( 13002); CAROIOVASC SYST -GENL STUDS.METHS{ 1 4501 ); BLOOO/BODY FLOS-GENL STUDS,METHS(15001); 8LOOO/BODY FLDS-BLOOD,LYMPH STUD(* 15002); RESPIRATORY SYST-GENL STUD.METNS(16001): TOXICOL-GENL/EXP STUDS.METHS(*22501); DISINFECT ION,DISINFEOTANTS,STERL('39500) Biosystemat1c Codes: HOMINIDAE(86215) (c. BIOSIS 198 R&S 138435 Jser 36 14 25nWB3 208 1 administration of the 3 compounds. Dally administration of compounds transformed Into reactIvo metabolites may load to a progressive decrease In hepatic cyt P-450 concentrot1 on and to the accumulation of metabolites Irreversibly bound to proteins t nthe 11ver. Descriptors: RAT LIVER BROMO BENZENE TRI CHLORO ETHYLENE VINYL CHLORIDE CYTOCHROME P-450 GLUTATHIONE DEPLETION PROTEIN BINDING TOXICITY DRUGS PHARMACO KINETICS Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACD{10064); BIOCHEM STUO-PORPHYR- NS.BILE PIGM(10065); ENZYMES-GEN.COMPAR STUD,COENZVMS(*10802); ENZYMES'CHEM,PHYSICAL STUDIES{10806): CHOROATE BODY REGNS-ABDOMENt11314): METABOLISM-GENL STUD.METAB PATHW('13002) ; DIGESTIVE SYST-PHYSIOL,BIOCHEM(14004); DIGESTIVE SYST-PATHOLOGY1* 14006); PHARMACOL-DRUG METAB.METAB STlMUl'220- 03); ROUTES OF IMMUNIZ.INFECT,THERAP(22t00); TOXICOL-GENL/EXP STUDS.METHS('22501); TOXICOL-PHARMACOLOGICAL('22504) Biosystemat1c Codes: MUR IDAE{8 637 5) 70047759 CUMULATIVE EFFECTS OF REPEATED DOSES TRANSFORMED INTO REACTIVE METABOLITES OF COMPOUNDS PESSAYRE O; WANDSCHEER J-C; OESCATOIRE V; OOLDER A; DEGOTT C : BENHAMOU J-P UNITE RECH. PHYSIOL. HEPATIQUE. HOP. BEAUJON. 92118 CLICHY. FR . BIOCHEM PHARMACOL Language: ENGLISH 29 (7).1980. 1041-1048. Coden: BCPCA Several drugs and chemicals are transformed In the liver by cytochrome [cyt] P-450 Into reactive metabolites that may destroy hepatic cyt P-450, deplete hepatic glutathione,1 and covalently bind to hepatic proteins. The possibility was Investigated that dally administration of the parent compounds may have cumulative effects on some of these phemonena. Rats received 1-3 i.p. doses of bromobenzene [BB[. 0.25 mmol/kg dally, trichloroethylene, 1 mmol/kg dally, or vinyl chloride, 0.5 mol/kg dally. Cyt P-450 concentration was not significantly decreased after n single dose. but was progress 1ve1y decreased after repented doses of the 3 compounds. Although hepatic glutathione concentration was decreased 4 h after the administration of a single dose of BB, It was not decreased 24 h after a single or repeated doses of BB. The amount of metabolite irreversibly bound to proteins progressively Increased In the liver during repeated DIAL le5: BIOSIS Previews 77-B3/jan BA7502:RRM2402(See I &S 138436 !) (Item 300 of 858) User 3614 25jan83 2082 700 <12628 ASSESSMENT OF THE TERATOGENIC POTENTIAL OF PLASMA SOLUBLE EXTRACTS OF DI ETHYLHEXYL PHTHALATE PLASTICIZED POLY VINYL CHLORIDE PLASTICS IN RATS LEWANDOWSKI M; FERNANDES d; CHEN T S DEP. TOXICOL., 60085, USA. ARNARSTONE LAB., INC.. MCGAW PARK. ILL. TOXICOL APPL PHARMACOL TXAPA 54 (1). 1980. 141-147. Coden: Language: ENGLISH Plasma extracts of2 polyvinyl chloride (PVC) plastics (designated PL-130 and PL-146) containing dtethylhexyl phthalate (DEHP) as a plasticizer and used In the manufacture of parenteral fluid storage bags were administered l.v. to pregnant rats dally from day 6-15 of gestation. Two groups of rats received PL-130 extracts In doses equivalent to 1.3 and 4.7 mg DEHP/kg per day, and 2 groups received PL-146 extracts In doses equivalent to 1.4 and 5.3 mg DEHP/kg per day. The higher doses are similar to those predicted to be received by a 60-kg human undergoing an .exchange transfusion of 2 1-day-old blood. A control group of rats received the plasma vehicle only. No differences were seen In the growth rates or behavior of the control and treated groups. There were no significant effects on feta! weights. or on crow-rump and t ransurrb 1 1 I ca 1 distances In offspring. The number of live and resorbed fetuses was not significantly different In control and treated groups. The incidence of gross external, skeletal and visceral defects among offspring was similar In all groups, and there was no statistically significant difference between control and treated groups. Plasma extracts of PL-130 and PL-146 were not teratogen1c when administered l.v. to pregnant rats during the critical period of organogenesis. Descriptors: HUMAN COMPARISON PARENTERAL FLUID STORAGE BAG TERATOGENESIS NEGATIVE Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES(10010); BIOCHEM S T UO-GENERAL( 10060); PATHOLOGY -COMPARATIVE( 12 503); METABOLISM-GENL STUD,METAS PATHW(13002); CARDIOVASC SYST-GENL STUDS,METHSt14501); BL00D/800Y FLDS-GENL STUDS.METHS(15001): BL000/B0DY FLDS-8LOOO,LYMPH STUD(`15002); REPRODUCT SYST-GENL STUDS,METHS( 16501 ) ; ROUTES OF IMMUNIZ.INFECT,THERAP{22100): TOXICOL-GENL/EXP STUDS.METHS(2250 1 ): TOXICDL-ENV!RONMNTL.IND- USTR(22506); DEVELOPMNTL BIOL-PATHOLOGICAL(25503): DEVELOPMN- TL BI0L-EXPER1MENT AL(25504): DEVELOPMNTL 8 IOL-GEN MORPHGENSIS- (25508); DEVELOPMNTL BIOL-EXPER TERATOL(*25554) B losys tenia t Ic Codes : HOMINI DAE ( 862 15 ) ; MUR IOAE ( 86375 ) most frequently used for blood storage bags (s DE(1P [ d 1 e thy 1 -2-hexy 1 phthalate]. In this study, a method for labeling DEHP with 14C from 14C phthallc anhydride was given. A piece of PVC from a commercial blood bag was labeled with 14C DEHP and was used to follow the kinetics of DEHP leaching In blood during storage. It was also used to study the Influence of some parameters such as the amount of blood tfplds, shaking, and plastic sterilization on this leaching. DEHP leaching was a 3-step phenomenon and the level was not correlated to the Ifpid content of the blood. Thermal treatment of PVC and shaking had an Influence on leaching. DEHP was not metaboltzed during blood storage at 4.degree. C and could not be detected as a free molecule: It was absorbed on plasmatic proteins. Descr Iptors: PLASTICIZERS Concept Codes: RAOIATI ON BIOL-RADTN,I SOIOP. TECH{06504); BIOCHEM STUO-GENERAL{ 10060): BIOCHEM STUD-PROTEINS.PEPTIDES.A - MINO ACD(10064); BIOCHEM STUD-LIPIOS(10066); EXTERN EFF-PHYSICAt.MECH EFFECTS( 10612): EXTERN EFF-COLD( 106 1 G ) ; METABOLISM-GENL STUD.METAB PATHW(13002); 8L000/B0DY FLDS-GENL STUOS,METHSt* 15001 ): BL00D/80DY FLDS-BLOOD.LYMPH STUD(* 15002 ) : TEMPERATURE-GENL.METHS(2 300 1 ); TEMPERATURE-CRYOB IOLOGY(2 3004 ) BIosysternat1c Codes: VERTEBRATA-UNSPECIFI ED(85150) 70028109 RELEASE OF DI ETHYL-2-HEXYL PHTHALATE IN STORED BLOOD IN CONTACT WITH POLY VINYL CHLORIDE nilOCOURr M P; P[CART O; SALEUN J P; FLDCtl H H LAB. BIOCHEM.. FAC. MED., BP 815. 29279 BREST CEDCX. f R. REV FR TRANSTUS IMMUNO-HEMATOL 22 (4). 1979. 343-358. Coden: RFTID Language: FRENCH Softness and Flexibility of PVC [polyvinyl chloride] are duo to the addition of plastlclzors In high concerntrnt1ons; the DIALOG F11e5: BIOSIS Previews 77-83/Jan 8 R&S 138437 ) (c. BIOSIS 1902) (Item 302 of 85B) User 3614 25J 2083 70028019 PH PARTIAL PRESSURE OF CARBON 01 OXIDE AND PARTIAL PRESSURE OF OXYGEN IN HIGH VOLUME PLATELET CONCENTRATES PREPARED BY DISCONTINUOUS FLOW CENTRIFUGATION AND STORED IN POLY VINYL CHLORIDE AND POLY ETHYLENE CONTAINERS ROSENSTEIN R; LAWE J E; NORTH U G VETERANS ADM. MED. REG. OFF. CENT.. WHITE RIVER JUNCTION. VT. 05001, USA. AM J CLIN PATHOL 73 (3). 1980. 397-399. Coden: AJCPA Language: ENGLISH High-volume (200 ml) [human] platelet concentrates prepared by discontinuous-flow centrifugation, with counts as high as approximately 2.0 .times. 1012/1, were stored In GOO ml-capacity polyvinylchloride bags or 800 ml capacity polyethylene bags. Polyvinylchloride and polyethylene bags appeared adequa te for 24 h storage of paltelet concentrates with counts greater than 0.5 .times. 1012/1. At 24 h the platelet concentra tes In polyvinylchloride bags showed a reduction In pH and an Increase in PC02 [C02 partial pressure] that were proportional to the platelet count. Only with storage in polyethylene bogs did the pH and PC02 of tho platelet concentrates show little change for periods of as tong as 120 h. BaserIptors: HUMAN Concept Codes: B1OCHEM-GASES( 10012): BIOCHEM STUD-GENERAL(1- OOGO): niOPtlYS-GENFRAL RI0P1IYS T ECI t( 10504 ) ; MOVEMENT ( 1 2 10Ol ; BLOOD/BODY FLDS-GENL STUDS,ME THS(* 15001); BLOOD/BODY FLDS-BLOOD CELL STUDS(* 15004) Blosysternat1c Codes: HOMINIDAE(06215) 70025664 COMPATIBILITY OF VERAPAMIL HYDRO CHLORIDE INJECTION IN COMMONLY USED LARGE VOLUME PARENTERALS CUTIE M R; LORDI N G DEP. PHARM., COLL. PHARM., RUTGERS UNIV., BUSCH CAMPUS. NEW BRUNSWICK, N.J. 08903, USA. AM J HOSP PHARM 37 (5). 1980. G75-676. Coden: AJHPA Language: ENGLISH The visual and chem teal comp a t Stoll 1 ties of verapam 1 i hydrochloride Injection In 10 commonly used large-volume so 1ut1ons packaged In glass, polyolefin or polyvinyl chi or 1de containers were studied. The mixtures, each containing 40 mg/1 of verapamil hydroch1 or 1de, were stored away from light for up to 48 h at 25.degree. C. The solutions were examined visually for haze, precipitate formation, color change, and evolution of gas Immediately after mixing and at 0.25. 1. 3, B. 24 and 4B h. Spectrophotometry and TLC were used to test for drug decompos1tIon or chemleal 1ncompattbllltles. All test methods used showed that no significant degradation of verapamil hydroch1 or]de had taken place In the solut Ions or through contact with the contaIners. Slightly higher spectrophotometr1c readings for dextrose-conta 1n1ng solutions, though within experimental error, could have Indicated the presence of dextrose degradation products. Evidence from this study suggests that verapamil hydrochlortdo Is compatible with the large-volume parenterals studied. Descriptors: DEXTROSE GLASS POLY OLEFIN POLY VINYL CHLORIDE DRUG DEGRADATION Concept Codes: COMPARATIVE BIOCHEM-GENL STUD 1CS( lOOIO):' BIOCHEM METH-GENERAL(* 10050); BIOCHEM METH-CARBOHYORATES1 * 100- 59); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-CARBOHYOR.(100- 68) ; BIOPHYS-GENERAL 8I0PHYS TECH( 10504 ) ; BIOPHYS-MOLECUL PROP,MACROMQLEC(10506); EXTERN EFF-TEMPERATURE( 10614) MOVEMENTt 12tOO); PHARMACOL-GENERAL STUDIES(*220021; PHARMACOL- -DRUG MET AB,ME T AB ST I MU(* 22003); TOXICOL-PHARMACOLOGI CAL{2250- 4): TEMPERATURE-GENL,METHS(23001) 70024649 HEPATIC LESIONS CAUSED BY VINYL CHLORIDE MONOMER IN HUMANS 8 CLINICO PATHOLOGICAL CASES PIALAf J; PASQUIER B; PHAN M; KOPP N LAB. ANAT. PATHOL., CENT. HOSP. UNIV. LYON. FAC. ALEXIS CARREL, RUE GUILLAUME-PARADIN, 69372 LYON CEDEX 2. FR. ARCH ANAT CYTOL PATHOL 361-375. Coden: AACPD 2 7 (6 >. 1979 (RECD. 1980) . Language: FRENCH Six hepatic angiosarcomas, 1 hepatoma and 1 hepatic fibrosis with portal hyper tens Ion In patients chronleally exposed to vinyl chloride monomer (VCM) are reported. The Industrial methods of synthesis and current knowedge on the carcinogenic role or VCM are reviewed. Hlstogenetlc and pathogenetic concepts of fibrosis and angiosarcomas of liver are discussed. Descriptors: CARCINOGENESIS ANGIO SARCOMA HEPATOMA FIBROSIS PORTAL HYPERTENSION Concept Codes: MICROSCOPY-HISTOL.HISTOCHEM TECH!0 1056): CYT0L0GY/CYT0CHEM-HUMAN(02508): SOCIAL BIOL/HUMAN EC0L0GY(055- 00): BIOCHEM METH-GENERAL( 10050): BIOCHEM STUD-GENERAL( 10060); ANATOMY/HISTOL-MICRO,ULTRAMICRSC{11108): PATHOLOGY-COMPARATIVE(12503); METABOLISM-GENL STUD.METAB PATHW( 13002): DIGESTIVE SYST-GENL STUDS.METUS( 1400t 1 ; DIGESTIVE SYST-PATHOLOGY( 14006); CAROIOVASC SY ST-GENL STUDS,METHS( 14501 ): CAROIOVASC SYST-BLD VESS PATHOL(* 14508) : TOXICOL-ENVIRONMNTL.INQUSTR(*22506): NEOPLSMS/NEOPL AGNTS-CAR- C3 NOGENS(*2 4007); ENVIRON HEALTH-OCCUPATNL HEALTH(370 1 3 ) : ENVIRON HEALTH-AIR,WATR.SL P0LLN(37015) B losystomat1c Codes: HOMINIDAE{86215) DIALOG e5: BIOSIS Previews R&S 138438 2(See F1t 70022724 THE RESISTANCE OF PACKAGING FOILS AGAINST THE LESSER GRAIN BORER RHIZOPERTHA-DOMINICA THE DRUGSTORE BEETLE STEGOBIUM-PANICEUM THE RUST-RED FLOUR BEETLE TRIBOLIUM-CASTAN- EUM AND LARVAE OF THE INDIAN'MEAL MOTH PLODIA-INTERPUNCTELLA SCHMIDT H-U PF LANZ ENSCHUT ZAMT BERL.. ALTKIRCHER STR. 1-3. D-IOOO BERLIN 33. V. GER. MATER ORG (BERL) Coden: MTOGA 14 (4). 1979 (RECO. 19B0). 241-258. Language: GERMAN The resistance of packaging foils made of cellulose acetate, cellophane. polyacrylonitrile. polyethylene, polyester, polypropylene. polystyrene and polyvinyl chloride (PVC1 against 4 stored-products pests was tested with an apparatus especially developed for these experiments. PVC foils (60 .mu.) as well as foils of polyester (50 .mu.) and polypropylene (30 .mu.) were not penetrated by S. panlceum and T. castaneum, and not as often as the other materials by P. 1nterpuncte11 a, but foils of cellulose acetate (50 .mu.), cellophane (50 .mu.) and low. dense polyethylene (50 .mu.) were penetrated and not insect resistant. The smoothness, rigidity and thickness could be the reasons for the Insect resistance of the tested material. The gnawing ability of the Insects might be Influenced by the shape and size of the mouthparts as well as the position of the mandibles In relation to the axis of the body. Only I PVC foil was resistant against the lesser grain borer (R, dominlca F.) but. since this pest is a!most exclusively Important 1n exports to the tropics, the majority of the tested packaging foils will protect the packed goods sufficiently against stored-products Insects of central Europe. Descriptors: CELLULOSE ACETATE CELLOPHANE POLY ACRYLONITRILE POLY ETHYLENE POLY ESTER POLY PROPYLENE POLY STYRENE POLY VINYL CHLORIDE GNAWING MOUTH PARTS EUROPE Concept Codes: BIOCHEM STUD-GENERAL{ 10060); FOOD TECH-PREP,PROCESSNG.STORAGE(* 1353 2 ) ; OENTAL/ORAL BIOL-ANATOMY- (19002); PEST CONTRL GENL/PESTICS/HERBICS(* 54600); ECONOM ENTOMOL-STORED PRODUCTS(*60008}; ECONOM ENTOMOL-CHEM PHYS CONTRL(*600 16); INVERTB PHYSIOL- I NSECTA -MORPHOL{*6407 4 ) Blosystemat 1c Codes; COLEOPTERA(75304); LEPIDOPTERA(75330) (c. BIOSIS 1982) (Item 305 of 858) User 3614 25J 2064 ponderosa pine plantations during spring 1978 near Bly. Oregon lUSA). Mating disruption treatments, replicated 4 times. wore 3.5 g/hn from 100 releasers/ha spaced at 10 m and 14 g/ha f rom 400 releasers/ha spaced at 5 m. Both were equally effective; the number of damaged terminal shoots was reduced 83.OX with the low dosage and 04.2% with the high dosage. Descriptors: OREGON USA TERMINAL SHOOTS POLY VINYL CHLORIDE RELEASER Concept Codes: GENERAL FIELD METHODS(01008); GENERAL FIELD APPARATUS(OIOIO): BEHAVIOR BIOL-ANIMAL BEHAVI OR(*07003); BEHAVIOR BIOL-ANIMAL COMMUNICATN{*07006); BIOCHEM STUO-GENERA- L(10060); ENDOCRINE SYST-GENERAL STUDIES(* 17002 ) ; PLANT PHYSIOL-GROWTH,DIFFRENTIAT(*51510); ECONOM ENTOMOL-TREE.ORN.WO PRODS(*600 10): ECONOM ENTOMOL-BIOLOGICAL CONTRL( *600 14 ) ; INVERTB PHYSIOL-INSECTA - PHYSIOL(*64076) Blosys temat1c Codes: CONIFEROPSIDA (CONI FERAE){2 5102); L E PIDOPT ERA(7 53 30) 70022633 MATING DISRUPTION WITH SYNTHETIC SEX ATTRACTANTS CONTROLS DAMAGE BY EUCOSMA-SONOMANA LEPIDOPTERA TORTRICIDAE OLETHREUTINAE IN PINUS-PONDEROSA PLANTATIONS 1. MANUALLY APPLIED POLY VINYL CHLORIDE FORMULATION SARTWELL C; DATERMAN G E; SOWER L L; OVERHULSER D L; KOERBER TW PAC. NORTHWEST FOR. RANGE EXP. S TN. , US AGR!C. RES. , FOR. S F IIV . . CORVALLIS, ORE G . 97331. USA. CAN ENTOMOL 112 (2). 1980. 159-162. Coden: CAENA Language: ENGL ISH A chemical mixture highly attractive to males of western pine shoot borer, E. sonomana Kearfott. were dispensed from manually applied polyvinyl chloride ralensors on 15 ha of 0 t ALO R&S 138439 le5: BIOSIS Prsvi,,.. 1502;RRM2402(See Fil 70020350 A COMPARISON BETWEEN CHLORIDE POWOERS AND THEIR PIGOTT G H; ISHMAEL J IN-VITRO TOXICITY OF TISSUE REACTION IN-VIVO POLY VINYL IMP. CHEM. MACCLESFIELD ANN OCCUP Coden: AOHYA INO. SK 10 HYG LTD., CENT. TOXICOL. LAB., ALOERLEY PARK. 4T J, CHESHIRE. ENGL.. UK. 22 (2). 1979 (RECD. 1980). 111-126. Language: ENGLISH A range of formulations of PVC [polyvinyl chloride! ' was subjected to an in vitro test [rat perllonea1 macrophage cultures] for cytotoxicity In vivo [specific pathogen-free rats] assessment of f1brogen1c1ty. The majority of the formulations show low cytotoxicity. In the case of emulsion paste polymers the cytotoxic effects observed were attributed to the presence of Industrial surfactant In the formulation. A1 1 powders tested In vivo. Including an examp 1e of an emulsion paste polymer, showed minimal In vivo tissue reaction when administered by either Intratracheal or t.p. Injection. The tissue reaction to PVC consisted of either a foreign-body reaction or a thin fibrous capsule only and was quite distinct from the progressive changes induced by .alpha, quartz. Descriptors: SPECIFIC PAIMOGEN-FREE RAT RAT PERITONEAL MACRDPHACES FOREIGN BODY REACTION INDUSTRIAL SURFACTANT ALPHA QUARTZ Concept Codes: CYTOLOGY/CYTQCHEM-ANIMALt *02506); COMPARATIVE BIOCHEM-GENL STUDIES(100 10); MINERALSC 10069) ; CHORDATE BIOCHEM STUD-GENERAL(10060): ' BODY REGNS-ABD0MEN( 1 13 14 ) ; PATHOLOGY-NECROSISf 12510); METABOLISM-GENL STUD,METAB PATHW(*13002): MINERALSf13010); RESPIRATORY SYST-GENL STUD,METHS(160Ol): ROUTES OF 1MMUN1Z.INFECT,THERAP(22100); TOXI COL-GENL/EXP STUDS.METHS(*2 2501 ): TOXI COL-ENVIRONMNTL.INDUSTR(22506); LABO RATORY ANIMALS-GNOTOBIOLOGY(28004); TISS CULTURE-APPARAT.METH- S.MEOIA(32500): IN VITRO STUDS-CELLULR.SUBCELL(32600): IMMUNOL/1MMUN0CHEM-GEN METH(34502 ); IMMUNQL/IMMUNOCHEM-IMMUNO- PATHOL(*34508): ENVIRON HEALTH-A IR.WATR.SL P0LLN(37OI5) Blosysternat1c Codes: MURIOAE(86375) 70017687 EFFECTS OF GONADECTOMY ON FOREIGN BODY TUMORIGENESIS IN CBA-H MICE MICHELICH V J; BRAND K G OEP. MICROBIOL.. UNIV. MINN. MED. SCH., MAYO BOX 196. MINNEAPOLIS. MINN. 55455. USA. J NATL CANCER INST 64 (4). 1980. 807-800. Coden: JNCIA Language: ENGLISH Sarcomas were Induced by s.c. Implantation of unplasticized po1yv1ny1clj 1 or 1de-v1ny1acetate films In gonadectom1 zed and norma 1 male and femag CBA/H mice. Gonadec tomy did not demonstrably Influence tumor Incidence and tumor latencies In males but significantly prolonged tumor latencies In females. E strogcn apparent1y Influences the pace of foreIgn-body tumortgenes 1s In CBA/H mice. Descriptors: POLY VINYL CHLORIDE VINYL ACETATE CARCINOGEN SARCOMA ESTROGEN SEX DIFFERENCE Concept Codes : GENETICS/CYTOGENET- SEX 01T F ERENC(*035 10); Ic. BIOSIS 1982) (Item 307 of 858) User 3614 25janB3 2085 BIOCHEM S TUU - GENERAL ( 10060) : BIOCHEM STUD - S T E R01. S , STF.RO IDS( 10- 067); ANATOMY/HISTOL-EXPERI MENTAL(*11104); REPRODUCT SYST-GENL STUDS.METHSt 16501 ): REPRODUCT SYST-PHYSIOL.BIOCHEM{ 16504 ) ; ENOOCRINE SYST-GONADS.PLACENTA(17006); INTEGUMENT SYST-GENL STUOS .METHS( 18501 ) *, ROUTES OF 1MMUNI Z . INF ECT , THER AP ( 22 100) ; TOXICOL-GENL/EXP S TUDS . ME THS ( 2 2 50 1 ) ; NEOPL SMS/NEOPL AC.NTS-CA- RCINOGENS(*24007) B losystem.it Ic Codes: MUR I DAE ( 86375 ) 70013433 ROLE OF RESPIRATION IN VINYL CHLORIDE MONOMER EXCRETION IN RATS ZUCCATO E: MARCUCCI F; MUSSINI E 1ST. R1C. FARMACOL. MARIO NEGRI, VIA ERITREA 62 20157 MILAN. ITALY. TOXICOL LETT (AMST) 5 (3-4). 1980. 213-218. Coden: TOLED Language: ENGLISH Amounts of 1. 5 and 10 mg/kg vinyl chloride monomer (VCM) 1n aqueous solution were Injected l.v. Into male rats wtlh cannulated tracheas. Respiratory activity was regulated to permit Investigation of the effect of modifying pulmonary ventilation on VCM excretion In blood and expired air assayed at different Intervals for VCM. VCM excretion rate was found to be directly propert1onate to pulmonary ventilation. When respiration was stopped for 1 min after VCM injection, there was no decrease In blood VCM. the main route elimination of l.v. Injected VCM thus being pulmonary. Descriptors: BLOOD Concept Codes: BIOCHEM STUD-GENERAL(t0060); PHYSIOLOGY-COMP- ARATIV( 12003): METABOLISM-GENL STUD.METAB PATHW( 13002): CAROIOVASC SYST-GENL STUDS.METHS(14501): BLOOD/BODY FLDS-GENL STUDS,METHS( 15001): BLOOD/BODY FLDS-BLOOD,LYMPH STUD( * 15002) : RESPIRATORY SYST-GENL STUD.METHS( 1600 1 1 1 RESPIRATORY SYST-PHYSIOL,B!OCHM( * 16004); ROUTES OF IMMUNIZ.INFECT.THE RAP - (22100): TOXICOL-GENL/EXP STUDS.METHS(*22501) B 1 osys teraa t I c Codes: MUR IDAE (8'6375 )