Document qmDLyzMr4DrMBqLyxE6wjeOVx

AR226-2834 Material Tested: Copies to: E, I, du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial! Mejdicine HASKELL IABOBATORY REPORT NO. 16Z-73 HaskelliNb.: 7857 Material Submitted by; lOrganic Cheniicals department, Jackson Laboratory Other Codes; ACUTE ORAL TEST Procedure: The tent material, as a suapenton in acetone:corn oil (15;85), was administered by to young adult ChR"C;D male rats in single doses. Survivors were sacrificed 14 days later; liver gravimetric analysis. i-i-r--.-i----------------i - . . ' Dose (nig/kg) 2,250 670 450 300 200 130 60 tiuspensio:a (%) 10 10 10 3 3 3 3 Mertaljl .ty* D 0 D - 4 d. 4 d. 4 d. S - 14 d. S - 14 d. a - 14 d. ;i - 15 d. Liver .^-.-..(Si " 18.8.3 15 27 13.91 17.46 L iver Wt. S odyWt. x l,,,w,. - 5.79 5.23 4.81 4.95 Clinical Si^ns Lethal Doses: Belly-tcl-cage postu mg/kg on day of dosing; ruffled fu weight loss from 1-3 ;days after do neal area on 3rd day :ater dosing Nonlethal Doses: Rufifl'ed fu.- at 6 above, lethargy at 130| ing/kg and a dosing; initial weight loss. --a ------------ f ^^^^--^^----lk------ ------------------"------------------- ...---- ------""," ""---------- |jmUHfl'-g Summary; moderately toxic when administered orally Co young adult Chit-CD male ra its Approximate LethaT Dose (ALD) is 450 mg/kg of body weight. Doses of 200 mg/kg and above pro animals 14 days after dosing. D - ( ) d. = Found dead ( ) days after dosing, S - ( ) d. = Sacrificed ( ) days after dosing. NCD:dhg Date; April Report by: Approved by; '~^L^,^/ ^f J3ra Company Sanitized. Does not contain TSCA CBi