Document qm4d522nEa4xk5LoxvbNo9dXM

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1949 Jan 31 DOC#: API 100 DOCUMENT DESCRIPTION: Minutes of the Technical Advisors of the Subcommittee on Carcinogenicity, Medical Advisory Committee, API with Attachments 1 A9 1 v-ixt-'''-'-,fJ T o d ) n} CoJ a S t a n d a r d O i l D e v e l o p m e n t Go m p a n y R esearch and Development Department 15 W e s t 51s t S t r e e t , N ew Y ork 19, N . Y. H . O. M . FISC H E R AMST. MANAOKR February 9, 2949 S rO T tT . Dr o Melver Woody Medical Department Building ^ mT IA L Dear Dr Woody: In response to year request as Chairman of the Sub immi':tee on Garclxicgsnicity of the Medical Advis ory Oommitl the A . P o l 5 dated November 2 2 # 2948, an invitation was e x tended to the members of the Medical Advisory Committee to a t tend a meeting for the purpose of considering the problem of sample testing T h e meeting was held on January ^I~-4rhi.9, in the AaPfllo Board Room 'nd' the" rec omme nda 1 1 on 3 arrived a t are given in the attached, The outcome of the discussion was reviewed by the writer at the meeting of the Subcommittee on Carcinogenicity on February 1* 1949s and since no serious objections were voiced by the members of your Committee, I assume that the technical advisors have discharged their assignment in a manner acceptable to the Subcommittee, I believe It was agreed that you will send copies of the attached review of the discussion to all members of the Medical Advisory Committee Very truly yours, HGMFsHC CC:Mr.D.V,,Stroop mU * I, yi, ^ t ia l 9T1230 BinEulM 01592 MEETING OP THE TECHNICAL ADVISORS OF THE SUBCOMMITTEE ON CARCINOGENICITY MEDICAL ADVISORY COMMITTEE AMERICAN PETROLEUM INSTITUTE January 31 ? 1949 Now York, N.Y.. A meeting of the Technical Advisors of the Subcommittee on Carcinogenicity was held in the A,,PJ., Board Room. 30 Rcckefeller Plazas Hew York City, at 10:00 A .Me, January 31,. 1949.. Present were: R 0 V/--1fC C o l e **-> . E. D c . j l e y .\'J0 OT Go Chard , . Hoag lx . . WJv Her ton. .-1 M ac k e n z ie H G, li,. P i s c h o r , H, L a n k a Ima W R.> Myors f o r H, iV, C, A , Sv/an P R., War^iok M, B-. w i l s o n f o r Hv licEver VJoody Ac t in g Chairman Field Euidema re-c e l y id from the f c l lowing n Uo vV Adams 7*> C s Board Ru s,, Eons it H ...0,1 c.0a,, regretting their in a b ility SEvitv of Discussion 1 Purpose of Meeting The acting chairman read his letter of January 7, 1S4S, to Mr. D., V,, Stroop {copy attached) outlining the purpose of the mooting to the effect that the technical advisors would redefine the objectives of the program to be co-ordinatsd by Dr. Horton and aid him with the selection of samples suitable for study by the Kettering Laboratory of Applied Physiology, University of Cincinnati, College of Medicine, under the direction of Dr. R. A,, Kehoe Tho group con curred In thi3<. 2 Objectives There appear to be two main objectives, which were worded as follows; (a) It is desired to establish in what crudes a tions thereof compounds are present that may possess carcinogenic properties and the type of processes that may either concentrate or create them and, if so, under what conditions 911230 BintulM 01593 -2 (b) Establish analytical procedures that will pe distinguishing betysen fractionsf according to biological costing.- that possess carcinogenic properties and those that do n o t0 it would be useful if an index could be devised whereby a refiner could m e a s ure the degree of carcinogenicity in fractions that are being handled in a refinery or in products that are delivered to the trade, M r 6 Mackenzie proposed that priority be given Item (b) because a suitable and reliable analytical procedure would deviate the need for biological testing of an unnecessarily large number of samples, The analytical procedure would screen the inactive or the least active from the most active materials for biological testing and would serve to avoid overtaxing the capacity of available-facili ties 0 The group agreed to the objectives as outlined, and to Mr, Mackenzievs proposal, 3, Selection of Samples for Testing, {a} Crudes The thought was expressed that the testing of various types of crudes from different sources {domestic and foreign': would produce information of value to the producing and operating oompanles, However, it was the concensus of the group that the test ing of crudes should be deferred until the examination of food s took:: from various sources to a variety of conversion processes and the study of products resulting therefrom discloses specific prooortic-r. that should be traced to crude source, in which case selected ormelee should receive closer scrutiny in the futures (b) Processes It appears that conversion processes, both thermal and catalytic, deserve prime attention. These were listed as follows: Thermal Gas .Oil . fiesids Reforming Coking Gas Reversion Steam Cracking In this connection, Dr, Lea Beard, in his letter of January 13 to H, G, M. Fischer, suggested that serious consideration should be given to "thermally cracked residuum from processes operating at high tern" peratures and on aromatic charge stock. If requested to do so, I b e lieve that it would be possible for ua to 3-u.pply you with a sample of vapor phase (Deplores) tar from an old DeFlorez unit operating on Mirando charge v/ith a transfer line temperature of about 900 911230 BinEulM 01594 1 3- Catalytic Hcudry TCC . Fluid ,, Houdriflow Cycloversion Hydroforming Catalytic desulfurization was also mentioned; however, It was decided that this v/ould he of marginal interest in vlev/ of the fact that the" operation is carried out. under relatively mild conditions with little., If any, conversion of the feed stock to lower or higher molecular weight products* This operation ma y merit consideration at a later date (c) M 1 eeellaneous Rod Wax Slack Wan Raw lube stocks *.vUa:.VJ.i.HiJu . Solvent extract iFurfural. ?he -Uv-' -i. , 3 G -,, A- In this connection, a sludge or oils derived from acid 3 ludge were mentioned The group agree would he of marginal interest in viev; OI ao fact that me contain relatively largo quantities of O-w,--"!fMi.lT-. acid and processing would he required to render them suitable for per mentation* The item will remain on the Vi-- rw aidsratioru procure :t acid . i#.1, u*i i. Referring to the previously quoted letter, Dr,, ice Beard also suggested "slack v/ax from pressing paraffin distillates, preferably where the paraffin distillate has had no acid treatment", and "Rod Wax - that paraffin which accumulates in the collecting ' lines and crude tanks, particularly from wells in California, which, because of their depth, produce 5warm* crudeo:! .It was agreed that Dr* Horton v?ill solicit from "ho companies participating in this program representative samples of the feed stocks to the processes listed and products therefrom, and whatever information can ha obtained on operating conditions and yields, and that he will concentrate his investigation primarily on queh samples as can be expected to yield the most pertinent informa tion for tying together the biological and analytical phases of the problem Dr, Horton briefly outlined the scope of his and lytlcal program* In this connection,, the acting chairman stated that extensive information had already been obtained v/hich may prove u s e ful to Dr, Horton and expressed the hope that all companies having such information in their possession would freely disclose it to him Dr. Horton stated that in his preliminary contacts with various com panies he had received excellent co-operation0 / 911230 BinEulM 01595 i... ! . . Samples Tostaci b?j the Kettering Laboratory Dr. Kcrion reviewed the results of the studies by tho Kettering Laboratory of Applied Physiology. College of Medicine, Uni versity -of Cincinnati,, on eight samples whi c h had been selected some time ago by the Subcommittee on Carcinogenicity* The results were rs = ported in detail under date of ilovsmber 5. 1943, by Dr. F, F- Kayroth; Only one sample, Oil No, W-3532 ia clarified oil from catalytic crack ing) disclosed a high order of carcinogenic activity, Another oil, W--353L, (a residual fron thermal cracking) produced only one tumor of a low grade of malignancy, A third oil, No* 11930, (a low-boiling dii tillats from catalytic cracking) produced changes in the skin cf two animals which gave a moderate evidence of malignancy.-. In this con nection, Dr. Horton stressed the need for subjecting as many animals aB possible to a pathological enaninaticn in order to avoid errors that frequently arise from gross observation, Ha cited an enamels- where lesions tbhoaat had boesen re ne-or ted as tumaoers by visual (Oil Ho* 3531; were f : nd to bo examined micros V - X -, "i mall grunt risen urea ..'.u:vi cnee '.0 1 1 was found that was not detected : 7 inure-:tion of i shin 2 :n turno:. The group agreed rune animals should re oc ivo a patholrgicdl results of the b i elogical testing a Gross euaminutior. appears to be rife samples which have a high carcerare- ho largest possible number of .nomination in ordot to nano the rolla els" and useful r-- -n qt rqor z;' *h**. ate fox' .-uclginr the results of ,o activity. oi*. . -cn O ,.. a n C*-j ^'-7 '.vC- o*Ti'- "J sumplce vf-sri prcc.uocd. .?.::i nine :lh.i data ar.c. operating so::...'lit.Lorn . Mr, V/arrick, who had be on instrumental ir. oh coining the ss samples . stated chat such information had net boon re cues tod, ns it was do'ubteci that it would have been furnished: however. he agreed to acquaint Dr, Horton with his contacts in procuring these samples and Dr. Hereon will attempt to obtain whatever information th c respective ccapan13 a may be in a position to disclose to'him. products 3curc35. gas tar, i>~ Products from Other Indus tries In order to permit drawing suitable comparisons be freer, derived from petroleum and products from other' related it is recommended that samples be obtained cf coal tar. us.ter and shale oil (domestic and foreign; for study*5 5, Funds Available In view of the possibility that .appropriated funds m y not be adequate to finance the work to be undertaken by the Kettering Laboratory when tho full program goes into effect, the question was raised as to how much, money vias available. According to information supplied by Mr<, Stroop, the Kettering Laboratory received a grant of 911230 BinEulM 01596 5- $25/300 in 3,948 which appears to bo sufficient to cover their operat ing exp,,en3es until July 1, 1949* An additional $25,000 is on denosit which can than ba made available if needed. In addition, Mr<> Stroop has Included in his list of subscriptions a request for $25,000 to bo ready for Dr,, Kehoe on January 1, 1950, to cover the six m o n t h s ' period to July 1, 1950. 0r o Horton indicated that he expected to have laboratory facilities available by June 1, 1949, and that the biological laboratory will be in a position to handle about one h u n d red samples, with provisions for approximately 4,500 mice. It Is anticipated that in order to carry out the recom mendations arrived at by the technical advisors, the Kettering labo ratory may require the services of an additional pathologist, and D r 0 Horton may require the addition of another member to his staff* The meeting adjourned at 12:45 ?,!o Koxy Dowling Acting Secretary 911230 BinEulM 01597 (COPY) STANDARD OIL DEVELOPMENT COMPANY Research and Development Department 15 Vest 51st Street New York 19, N.Y. Mr. D. V. Stroop American-Petroleum institute 50 West 50th Street New York City January 7 ,19^9 Dear Mr. Stroop: You will recall that among the recommendations adopted at the meeting of the API Medical Advisory Committee Sub-Committee on Carcinogenicity on November 11, I9W , at Chicago, Item k (appearing in the minutes) reads as follows: "That the fundamental chemical and physical studies that are indicated to investigate the operational technical aspects of this problem may require considerably more money than anticipated; and it is recommended that the technical advisers group consider the problem again and present their recommendations to the Sub-committee on Carcinogenicity." In this connection, Dr. MeTver Woody, Chairman of the Sub-committee on Carcinogenicity, has written me as follows: "Now that Dr. A. Wesley Horton has been selected by Dr. Kehoe to investigate the chemical aspects of the problem, it will be greatly appreciated if you would call a meeting of the technical advisers to confer with Dr. Horton on methods of selecting samples for future testing, taking into account the nature of the crude, its source, the temperature . conditions, etc." As I understand the situation, it is desired that the technical advisers redefine the objectives of the program to be coordinated by Dr. Horton and aid him with the selection of suitable samples for study by the Kettering Laboratory of Applied Physiology, University of Cincinnati, College of Medicine, under the direction of Dr. R. A. Kehoe. I shall be glad to conduct this meeting in response to Dr. Woody's invitation and would suggest the date of January 31, 19^9, in the API Board Room on the 20th floor at 50 West 50th Street, New York City, at 10:00 A.M. Since the group will wish to arrive at definite conclusions and recommendations, it is hoped that the technical advisers will find it convenient to attend this meeting in person. If you are in agreement with this method of putting into effect the recommendation adopted by the Medical Advisory Committee, I shall appreciate your extending an invitation to Dr. Horton and the associate members of the Medical Advisory Committee to attend this meeting and to others who you feel would be interested in participating in the discussion. Please advise Very truly yours, HGMF:HC CC: Dr. Mcl.Woody Dr. J.P.Holt /s/ H. G. M. Fischer H, G. M. FISCHER noon 01598