Document qm0JwExpKRMEGXbqBy3jMX9Qn
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E . 1. d u P o n t d e N e m o u r s & C o m p a n y
INCORPORATLC
W i l m i n g t o n . D e l a w a r e 19898
POLYMER PRODUCTS OLTARrMENT HXPITR I M L N T A L S T A T I O N
PERSONAL AND CONFIDENTIAL
cc:
A. J. Dahl L. J. Papa Pral File I .C.
- 353 - 269
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July 16, 1981
DR. B. M. KARRH MEDICAL DIRECTOR WILMINGTON
ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 810-578; PRAL Nos. 81-1555-1557,81-1614-1619,81-1662-1671, 81-1713-1721,81-1816-1818,81-1848,81-1862-1865; Notebook Nos. E22514,E26238)
As requested in your letters of 4/20 through 4/30/81 to L. J. Papa, the 36 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table.
As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) hut results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10L relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of 'v 0.004 ppm which can be distinguished from the reagent background but not veil quantitated.
Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses.
Attacliment jah
Key Word s : Perfluorooctanoic Acid Pc-r fluorooctanoate Blood Analysis GC
S. S. Stafford
There's a w orld ol things wc re domg something about
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TABLE I CONCENTRATIOK OF PERFLllOROOCTANOATE IN BLOOD (a)
Sample PRAL N o . Date Sampled
81-1555
4/20/81
81-1556
4/20/81
81-1557
4/20/81
81-1614
4/21/81
81-1615
4/21/81
81-1616
4/21/81
81-1617
4/21/81
81-1618
4/21/81
81-1619
4/21/81
81-1662
4/22/81
81-1663
4/22/81
81-1664
4/22/81
81-1665
81-1666
4/22/81 4/22/81
81-1667
4/22/81
81-1668
4/22/81
81-1669
4/22/81
81-1670
4/22/81
81-1671
4/22/81
81-1713
4/23/81
81-1714
4/23/81
81-1715
4/23/81
81-1716
4/23/81
81-1717
4/23/31
81-1718
4/23/81
81-1719
4/23/81
81-1720
4/23/81
81-1721
4/23/31
81-1316
4/27/81
81-1817
4/23/81
81-1818
4/28/81
P.R.No.
Name
GC Ana 1v s i s _ _______________________ ( b ) Date Analyzed [Cr ], jr F/f. blood
4/22/81 4/22/81 4/22/81 4/23/81 4/23/81 4/23/81 4/24/81 4/24/81 4/24/81 4/27/81 4/27/81 4/27/81 4/27/81 4/28/81 4/28/81 4/28/81 4/28/81 4/29/81 4/29/81 4/29/81 4/29/31 4/30/81 4/30/81 4/30/81 4/30/81 5/1 6 5/5/81 5/11/81 5/11/81 5/2/81 5/4/81 5/4/81
n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d.
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TABLE 1 CONCENTRATION OF PERrmOROOCTANOATE IK BLOOD (a)
Sample PRAL No. Date Sampled
81-1848 81-1862 81-1863 81-1864 81-1365
4/29/81 4/30/81 4/30/81 4/30/81 4/30/81
P.R.N'o.
Name
GC An a_]ysi s____________________(b ) Date Analyzed [Cp ], Up F/p blood
5/4/81 5/4-5/5/81 5/4/81 5/5/81 5/5/81
n.d. n.d. n.d . n ,d. n.d.
(a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard.
(b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit for quantitation is 0.007 UgF/g. The detection limit is r 0.004 ygF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. Kone detected (n.d.) is reported for samples with [CgJ < 0.004 ppm, which cannot be distinguished from reagent background.
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