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19 S? CONFIDENTIAL / ; REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1987 PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1. The 10 new cases in the Register are the following: France 19, 20, 21; Germany 28, 29* 30, 31, 32; UK 13, USA 39- 2. There are amendments from the previous-Register against the following cases: France 15; Germany 23, 26. 3. I would like to thank the following for informing me of new cases - Dr Contassot, Dr Barrat, Dr Landers, Dr Friedel, Dr Williams and Mr John E Ertel. 4. For the case corrections I thank Dr Contassot and Dr Friedel. 5. For other corrections and information thanks to Mr John T Barr, Mr John E Ertel, Mr R T Gottesman^ Mr A King and I r N A Sulaiman. 6. I should be very grateful if all recipients of the Register could continue to keep me fully informed of any new cases or if they hear of other Companies who have acquired a case of ASL, it would be much appreciated if I could be notified by the appropriate person. It is very helpful if new information is supplied in tabulated fora, using the headings in the Register as far as possible. For this purpose I have added a blank form at the back of the Register. 7. I would also be glad of help to keep the mailing list correct, with news of retirements and successors, etc. 8. Research: (a) I am enclosing a letter which explains a research project in which I and Professor Carlo Tamburro hope you will be able to co-o>erate in the interest of knowledge. (b) I shall be very grateful if all individuals involved in research or surveys could keep me informed and if possible send me copies when they become available. Fnm: Dr Brian Bennett Occupational Health Department ICI Chemicals & Polymers Group Hillhouse Site P 0 Box 4 Thornton-Cleveleys Blackpool FY5 4QD England February 1907 098600 S9U ' ndex Table Sequence Belgium Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Case6 per annuiu (Table i) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) Distribution of Latency Periods (Tables 4B-4I1) Aj^ial Geographical Incidence W (Table 5) IS8680 SSH ICI CHEMICALS & POLYMERS GROUP WPX/ASO - LANGIOCASES,4 LIVER ANGIOSARCOMA CASES (REVIEW DATE - ? JANUARY 1987) Pat e 1 2-3 4 5-9 10-15 16 17 18 19 20-23 24-30 31 32 33 34 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Australasian PVC Producers - Start-up Dates (Table 14) Middle Eastern PVC Producers - Start-up Dates (Table 15) Blank form for notifying new cases Paj 44 45 46 47+4 49 50 51 52 53 54 35 36-42 43 * - IMtfi* I HU i.iOH t,in CHEMICALS POLYMERS GROUP LIVER An*lniirciMft Cases Review Date January 19RJ) ui-x/asl - laniJidcases.a 1 l1 I i oilhTky AND t REFERENCE I mi 1 1 BELGIUM m k 1 1 1 1 J | 1 J | | f | 1 f 1 1 2 NAHF. NR INITIALS 1 I1 F 1 1 date or | MR Til 1 1 1 1 |12,01.11 l I 1 I f | | 1 1 1 | 1 1 l I 1 1 | \ 1 1 1 1 1 1 1 Ml | SR | l | | | 1 1 i 1 1 | i ! 1 F79 09 AO 1 1 1 t ) \ | 1 | 11 A COMPANY Solvay Solway i 11 1 1 11 i * 1 6 1 7 1 a i 9 1 10 1 11 1 i 11 l 1 11 j l1 l \ 11 ! | MAST VC | DATE OF 1 ACE AT 1 YEARS OF | YEARS OF 1 DATE OF [ HISTOLOGICAL | FACTORY L EXPOSURE | DIAGNOSIS 1 DIAGNOSIS | EXPOSURE TO | EXPOSURE f DEATH | CONFIRMATION i t i i DIAGNOSIS i it i i t j________ l 1 ii 1 i ii 1 ii 1 i ii ii ii i i* i 11 11 ESTIMATED f ( EXPOSURE \ OCCUPATION | LEVEL ) \ 11 ii ii nI I* J------------------------------ OTHER CAREER HIGHLIGHTS | OttltH | COMMENTS 1 J____________________ t i { Jemeppe 1 00.07.1* 1 00.01.7* i1 1t i1 I1 I| I\ 11 11 11 i1 1| 11 |1 1r 1i 1t 1i i 1i Ii 1i ii ii ii |i ir ii ii i 1t ii it 1i 1 Jemeppe 1 20 08 62 1 00.10.7* i1 i i\ l 11 ii 1 1 ti ii 1I | 1 1 1 1 1 1 1 1 t 1 1 1 | i i i i i i i i i i i i i * i i i i i i 1 1 \ * 1 i i i i 1 63 39 1 it 1 i* t i i i t i i i i i 1 1 1 i i t i i i i i i i | i i t i 1 i L 1 1 17 t i i t * i * i t i i i i i 1 17 [29.0fc 76 | 1 ii 1 ii f ii Tee High fAutocleaner tOrtller In 11K yra |foundry 1*16-1*6* | 1(7 yr.) expoaed to)Polyworfcer |Paner i liepat 1 r teat* (In Oct 1974 |were nor**1. |Ret 1 red 1 11 1 ii 1 1i 100 pra |1 yr. for S hra [ per day | 1(11 yr.) | Feb 1975 (Work, in glaaa |Moapltallaed Find* A chml* | May 1976 1 ii 1 ii 1 i1 1 ii 1 i1 1 11 1 ii and | certainly | under | 100 PP tn 6 to 1 1 *j i autoclave*) teal | | 1 | t | Industry 1 j Complete (Clinical and fcareer deln1 la fare Riven In a (paper by IMublet et al 1 ii 1 ii 1 1i 1 i1 1 ii 1 it t ii 1*66-1*72 | eapnaed to] 50-200 ppn | 8 hr* per | day In 21a1 1 1 autoclave*) | f f | | t | [1n Arch* del*. |Med. Soc. t (Hy*. Had. |Trav. Med. (Leg. F1977 pages (601-622 \ ii 1 ii 1 i! 1 i1 f i| (*77-1*7* I expoaed to| 10-200 ppa| In auto- | clave rou| 1 | | 1 | 1 | t 1. I 1 11 1*74-100 1 | 1 1 i1 PP* 1 1 i 1 it 1975- 50 | | 1 1 i1 \ i1 PP RETIRED 1 | 1 | 1 i t 1t 1 Feb 19751 f 1 1 11 1 i1 | * in 10 *1 1 T. 1 11 1 11 1 11 1 11 1 11 I1 11 08.62-03. 61 01.67 -10.71 * 200 ppa Sh/day 0*.61-12. 66 * 200 Pt* !1 ll 1 |Autocleaner (flreusn ilnce (fat Ign July |1 yr* 1 ath.llO >1. |79: Thorar1c Itiperator 1 11 yr. *ath. .1 || I1 || (pain 07.79. |HepatIc teats lettered 10.79. |Poet11 we |echoRraphy 1t 111.79. Hep*- 11 11 1 11 i < i 11 f | i i 1 i 1 2S86S0 SSH --! i i i i | i ' 11 ectnay 07.80. |Chenot herapy. 11nfarmtt1 an Iglven In llettei 17 Now $ ( 984 f i ( Dr | lie SI nnve i . esseeo ssa IM^.' * I AN AH A si..... I I , CHEMICALS 4 POLYMERS CROUP LIVER Angiosarcoma Cant'S - (Review Date: I Jan 19S7) All dales ust* iih Nyst t UAY - HON1II - YEAR wpx/asl - i.ANcmrrASf.s, r in rm/Nm A*u KKIEKENCK NO WANE <>R INITIALS PATE OF SI RTH FIRST VC EXPOSURE OATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP death HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAKKKK IIICHU CUTS OTHER COMMENTS SHAWINICAH 01 1 1 1 I 1)2 1 1 t 1 1 111 1 1 1 1 1 04 I 1 1 1 1 l oi 1 * 1 1 1 06 1 1 I 1 1 Of 1 l 1 1 OR I 1 l 1 09 1 1 1 1 IIS.12.11 | 11 11 11 ms.oi.it i 11 ll 11 li ut.oe.n t ii ii il ii 105.0*.19 1 1 1 1 1 1 ioj.ns.li 1 1 1 t 1 i l l 1 I ns.n.t9 l l 1 i t i i i 109.11.19 i i i | 11 11 11 111.05.10 | 11 11 11 119.02.11 1 1t 11 11 i i 194* i 1955 i 41 i it i " 101.09.55 1 Yu 1 ii ii i l ii h _L_ i 11 t lI 1 1 ii i 1 l t 11 1 i i 19*1 i 1957 1 4] i u i 14 <11.11.57 | Y* | ii i 1 l ii i 1 l i 11 i 11 1 1 ii I _]_ __ L ......... t...... _JI ! ii i 1 1 i 11 1 i i 19(1 i 1962 * 1 42 1 21 i 10 111.01.41 1 Yc 1 ii i 1 1 i 11 1 ii i 1 l i 11 1 ii I 1 I i _]! t ti i 1 1 i lI 1 i i 19(5 i 1947 1 (S l 22 t 21 lll.ul.4f } Iti | ii i 1 1 i 11 1 ii i 1 1 i 11 1 ii t 1 1 t 11 1 ii l | 1 i t1 1 ii i 1 1 i t1 1 i i I9(( i I960 1 57 1 14 i Oi 105.07.40 | t 1 ii i 1 1 i 11 1 ii i 1 1 i 11 1 ii l 1 f i t1 1 ii i 1 l 11 1 i i 19(7 t 1971 l SI 1 24 i 11 MO.04.71 | t*4 1 ii i 1 1 11 1 ii i 1 1 11 1 i it1 11 1 ii i 1 l i 11 t i i 1946 i 1971 1 51 l 26 t 25 114.11.71 | Tea | ii i 1 1 i 11 1 ii t 1 1 i f1 1 ii I | 1 t 11 1 ii i 1 l i 11 1 i i 1961 i 1971 1 51 1 12 i 05 111.04.71 1 Yea | ii i t 1 i 11 1 ii I | 1 i 11 1 11 i 1 1 i 11 1 J 1 1946 i 1974 1 51 1 2B i 26 II 4.09.74 | Yea | 11 i 1 1 i 11 1 11 i l 1 i 11 1 11 i f | i 11 1 tReactor (cleaner (Operator |Smoker (polymertaatIon | i 1 (Maintenance (Operator 1*11lwrl*ht, IplpefItter (Worked (overtIme |Smoker i |Operator, |foreman 1 |Worked (overtIme |Mon-amoker i |Re actor 1c leaner t 1 J |Reactor |cleaner 1 j (Operator, (foreman, |weter cooling (unit | Worked (overtIme |Smoker I IVat er cool 1 or (Worked |unl t |overtIme (Smoker 1 lReactor |cleaner 1 t (Halntenance, (ml 1Iwrlght L Worked (overt Ime (Smoker - 1 IReactor (cleaner 1 i (Machine ahop (operator and (poly unit |Worked InvertIme iSmuker } |Reactor 1c1eaner i 1 Halnt enance |In p!anl {machine ahup 125 yral Smoker i I 1 Furnace op. Iplpef1t1er |nalntenance 1 Worked (ovritIme |Smok r r i r *Y IJ f DM nMHh In Anna Ira d'Analum e patho "Rlpie Pails, I9M VoL 21 Ho 2 pplUS- 114 cIaIma It cane had both i hepatoma and ASL a 1 ail t anenue1y. Fj**e 1 CANAHA Sit v el I country anii REFERENCE NO HAKE OR INITIALS DATE Or tlRTH 6.05. IS 1C I CHEMICALS 6 POLYMERS CROUP P LIVER Angloaarcoma Caeca - (Review Date: I Jan 199 DAY - MONTH -*YKAK All date* uee UK ayete* upx/asl - i.aw;m:asls,r 1 ; 10 o 14 factory nm vc EXPOSURE DATE OF 01 ACNOSIS ACE AT DIM! NOStS TEARS Or EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COHMT.NfS n1951 197* 61 14 00.04.T1 Reactor cleaner furnace op. alntenance, packa*inf Em-anokrr c:> frS860 S'Jd SS86S0 S'Sd ^jto 4 It CHOSI.OVAK 1A id chemicals a polymers croup LIVER Anglosarcoaa Caat* - (Review Ofltr: l J*n 87) WXfASL - l.ANGHM'ASh.S,* 1? 11 14 n l iMIKTHT AND REFERENCE Hi} NAME OR INITIALS DATE OF BIRTH FUST VC UP05UBE DATE Or DIAGNOSIS ACE AT DIAGNOSIS YEARS OF , EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER Cl IHHKNIS CZECHOSLO VAKIA 01 2A.06.7fl St *t e Co Novafcf 01.07.57 74.12.75 *5 16 16 74.17.71 Autoclave Cleaner IARC letter of 1-4-B2 giving det af I* f ro* Prof A David of Centre Ind Hygiene and Occ disease*. 07 06.07.27 Kovily 01.11.50 27.11.64 37 14 15 26.It.64 Autoclave Ct eaner IARC letter of t-4-82 gave ouewhat altered dates for this esse. I have accepted the change* alnce the dates coat Iron Prof A David of the Centre of Induat rIal Hygiene and Occupational Dtaeaaea, Hy date* cone ortglnally fro* NtOSH. ?<* } KANO!, She el I 1CJ CHEMICALS A POLYMERS CROUP LIVER AngloBarcna* Case* - (Review Rite: l Jen A7) WPX/AS1. - LAWilHCASKS, *11 COUNTRY AMO KfVFKENCtv HD NAME OR (NlTIALS DATE OF BIRTH 01 5.n*.a* 1 07 ) SIK i 1 1 i 1 i i 1 03 | NAV 11 10] 06.11 t PCUX ii 11 ii li 1i it ii 11 106 01.20 | RP 10 1 I 17 u 15 FACTORY FIRST VC EXPOSURE DATE Or DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE .TO DIAGNOSIS YEARS OR EXPOSURE DATE Or DEATH H1STULOGICAL CONFIRMATION ESTIMATED 1 EXPOSURE | OCCUPATION LEVEL | * ________ l__________ I OTHER I OTHER CAREER 1 COMMENTS HIGHLIGHTS | __________!_________ II Looaa11 Ion 00.01.46 16.OZ.67 43 Zl ii 1 |Itlgnoud 1 06.01.59 1 15.01.15 1 63 1 1 16 i1 1 1 1 i1 1 1 1 i1 1 1 i1 1 1 1 i1 1 1 1 i1 i1 11 11 1 1 _]_ 1 111 1 St Tone | 00.00.*ft I 15.01.15 1 55 1 19 II 19.OZ.67 High |AutocIeve |Ref . Rav ter el 1 worker end |a 1 Arch. Ha I (cleaner (Prof. 1 10 n' |19 yre I I 3 Nov 7 5 Ip 171-17/ J___________ 1 11 i1 1 1 11 124.01.75 1 Yea i High |7 jrra on (Italian 1 i 1 (NIOSH no i laonoaer forlgl n t i 1 cotnt) i 110 jrri on | 1 i1 i Ipolfur- | 1 i1 i (leetlon | 1 (Ref. |C lonneton el |el "Houvelte |preaae |wedlea It* t i1 ii i |5 Nov 1977 1 i1 ii i IP 135 1 _j _]_ _j___ i _____________1____________________ 1 i1 i1 1 1 1 19 119.06.15 1 Tea i High (Polyworfcer |VCH product font Ref Rely el |10 yre ee 16 ru 1*1 Arch. K* t . leutoclave tie)Ian PQW~ jprof. 1 il n' |cleaner 1 Confounding n rr Shepherd, Ib June 11 Sivfir, Heaon |p 551-555 I 17.01.11 ftrtgnoud If.10.A* It.01.1ft *9 1ft Ift Oft.01.1ft 19.01.J8 Brlgnoud 18.01.65 13.05.1ft 38 13.05.1ft 958600 HI Ah t Honoaer I product Ion luorfce H Tr* 1 fVC |(111i.tI on I 18 jrt J_______________ High I Polyuorfcer III jrr. I I I tJThoreciitonjr JRef. P Condere 9th feb 1976 |et el 'Sewaftie coetat |dee hoaplimi engloeerroaha 111) Septrwbre 7)Sc Ini tgraphjr| 1976 found ASI. fPrevlimaty hail DHeenorrhage |bone I roa ASI. t angloeaTCiBHa" *)*l*hr 1A1 mo Hepeteetnwy | PI I Irlinuali I et | a I "l.e Niuiv i* 11 IPf eaae Hedl*a I * | 7 11i Inly Mf/9 ____________________M`*R ?*H5 ZS86C0 SSH V** K Cl CHEMICALS A PU1.VHLRS CROUP WKX/ASI. - LANG UI CASKS, M l K ANi'K Mi*ei 2 ' LIVER Angloptsmina Cases - (Review Date: 1 Jan OHM 1 t1 |2 i^1 1 i1 1 1i COUNTRY ANII | NAME OR | DATE OP i |REFERENCE I INITIALS 1 BIRTH Nil l 11 1 11 FRANCK 1 l i1 i1 A COMPANY flh IP* 1 1 1 l 1 1 1 1 1 1 1 <12 | Cl R 1 1 1 1 1 1 OR IB l 1 1 1 1 IH.04.1t 1 rent 1l 1l 1t 1l Il 1I 1I 1l 1l 11 1l 126.04.31 l *f 1I 1l 1l 1i I 1l 101.04.14 | Solagy 11 11 t1 11 11 11 1116 11 11 7 1 0 1 9 1 10 1 11 ii 1 12 1 11 1 14 i H 1 IN 11 1i 1 | FIRST VC I FACTORY | UPOSUBt 11 1 1 DATE OF 1 DIAGNOSIS 1 1 1 1 ACE AT 1 DIAGNOSIS 1 1 1 1 YEARS OF t EXPOSURE TO 1 DIAGNOSIS 1 J 1 YEARS OF I EXPOSURE f 1 DATE OF DEATH J__________ j 1 HI*STOLOGICAL | ESTIMATED 1 | |CONFIRMATION f EXPOSURE | OCCUPATION LEVEL t OTHER CAREER HIGHLIGHTS 1 I | 1 OTH1K COHHFNrS 11 11 11 11 1i 1t 1Btlgnood 101.03.18 12.08.76 1 42 | 19 11 1t 1 1t l1 11 11 t 11 11 11 11 1t 11 11 t1 11 11 11 .1 J__________ J 11 1i 11 1i t 1 ii 111.01.76 f Tea 1 Moderate ({1118-1160/ i 1| |2 yra i 1 i*y I lllltratIon i 1 112.01.76)1 |I0-II yra i t 11 |potyworker i 1 11 land worka t 1 11 llabT i 1 11 t t 1l 1i 1 11 ti J 1 1 | Title m*n had | AOL prior t * (AS, Ann. <te (Hal. Prof. (July *77 (p 6AS 6 6. |AOL wee found 11n 1971 live lyre helot* IASI. 11 1t | St Auban | 01.01.10 11 r1 it i1 Al ter death HI OSH tey* 00,07*76 1 1 1 1 1 1 1 41 1 1 1 1 1 1 26 1 JL J__________ j 1 11 i\ 1 22 102.07.76 Tea | High (Plant fore* 11177-6 ad.In I Died of 11 (ItlOSH no 1 1a*n In laectlon In 1 a epttrace)a 11 11 coeeient) \ (polyner(fiat Ion I St Auhan 1 ISeall liver |l ealon f mind t1 1 (after eutopay i i ITavaux 1 1 I 21.01.17 01.12,71 1 1 1 42 1 1 | 11 11 11 1 11 110.01.77 j________________ J t1 Tee | Moderate |6 yra packer! i 1 |Hait been 11 11 1t 11 11 1t 11 11 11 11 11 11 11 11 t1 |4 autoclave | 1c fnr 1 \ M yra \ (autoclave | (worker | (tunnel worker (previously 1 1 1 III!1I--------------------------------------------------------------------- j---------------- L 119 (AFX 1 l ) ( 1 1 1 t 1 1 1 I 1 1 1 I 1 1 1 10R,I0. 16 | RP ii 11 ii i ii 11 1i 11 ii 1 tt 11 1i r i1 i1 ii i1 il l St rone i 10.01.69 | 26.06.76 i 63 I 71 ii i i i ii i i i ii i i i it i 1 i ii i i i| ii ti i1 i i i ii i i i it i i i t i1 ii i i i 1i 1i ii ii i1 i i 1 11 i i ii i ii i i 1i 1l 1i 1 1 28 1 1 1 1 1 1 1 1 1 1 1 1 r i i i i i i j2S 12.77 | ti ii ii ti ti ii it ii ii ii ii i ii i1 ii ii ii ii ii Tee 1 Very Higi |poljrer- |10 yra In | I969~t96* (iaatlon (sulphuric (acid factory ( Eapoeure lautocleaner storekeeper ' t 1966-1976 lent :tave (general | laah.temnce 1aervli ea ii i ii i ii i ii i it i ii i ii i ii i 11 i ii i ii i 11 i 1f 1 11 J |Operaled 4. 7h Ifni reuovel of | I uaflur f rm 11 Iver and Idled after | second Irurgfca 1 loperatInn tor 1b 11 In |t ronrhf a t 1(1 etui * |Paper by | Dr Ret y el < 11 n Arrhl vet. di< | Ha 1 ad i'M | Prof eta Um.i t n | Vot 41) N.i t. 1 [111 1/41-1. 1 f*f ICI CHEMICALS t POLYMERS CROUP UPX/ASI, - I.ANOIOCASES.ll RANGE 1( LIVER Angloarreuaa Casta - (Review Date 1 Jan I9R7) l COUNTRY AND khUKENCK HI) h r a in e in II 11 2 1 1| A (1 11 NAME UR | DATE OF 1 INITIALS 1 BIRTH | COMP AH If tl l1 1i *i 1 VP 124 .01.19 1 RP Il 11 || ii i.1.02.12 ! 11 1 i i i i1 (1 i 1 l \4 1 1 Ia i i 1 10 i 11 1 12 i n 1 14 i 1 1 1 J! 1 i1 i i 1( 1 1 1 \1 l 1 1 ( FIRST VC | DATE OP | ACE AT YEARS OF 1 tears op 1 DATE OF | HISTOLOGICAL | ESTIMATED | l FACTORY 1 EXPOSURE | DIAGNOSIS | DIAGNOSIS | EXPOSURE TO | EXPOSURE r DEATH ( CONFIRMATION 1 EXPOSURE | OCCUPATION 1 11 t | DIAGNOSIS i * ii ( LEVEL 1 1 11 i r i ij J J________ 1_ i1 ii i ii ii i i1 t i ii i i 1 it 1 1 OTHER 1 \ CAREER | HIGHLIGHTS 1 J 1 1 16 OTHER COMMENTS Y (St Pona 1 i i i St Pona 1 00.12*14 | 10.01.78 1 1i 1 1t 1 1I 1 1i 1 1 (500T J! Toon it tt 1 71 1 1 1 1 IT 1 21 1l0.01f7E ( ii i 1i i 11 i 1i j II J TTTTTTFj Tea 1 High |Autoclave |10 yr. In |Dled of 1 (cleaner |aechanlcal |pul nonary 1i jengineer 1n* leabollia 1 1i i1nduatry (daya after 1 tutt-mt | aurge ry J j__________ j___ : High Il44l-I1tt j fpolyaer- |litlon 11 nI | 1 | | 1 1 It.0E.It rcuK Irlgnoud 01.01.t1 00.0i.11 ts 10 17 ll.0t.11 1.* 111.01 11 | Solr.y t 1 1 1 1 1 \ 1 1 1 Cti t I (Fora RP) |Tavaua i i 1 i i 1 i I 1 i ll.01.tl j lt.06.l4 i1 p1 i1 i1 i1 t1 i1 I p1 _L t 1 1 t 1 1 1 1 1 | 1 1 to L 14 . 1 1 1 1 1 1 ---1-- 11 11 :.0iJl t *] | Tea i i 11 i 11 i 11 i 11 i 11 I 11 i I1 i 1 t I - tpurpoae (worker llltt-iill |CM |.ynthe.l. IfHCI 1 IAc.tyl cnc) I fOTMifl |{*g*nt |j MltTlIt) 11171 High I r *t 1 red I -1 1Honoaer lytoductton fond polyaer- | loot ton i i i i i i i i 1 \ .i _ X Autocleaner |2 yra aa cyrl e(Clgaret te il rr*. (Auto- faechanlc. 110 yr. .. laaoker until 11974. Ill all (operator fenaaetler In 'of 197 7 due to 11 yr. (aanltary ware Ocaopliageal (Copol* irra It yr. | | | 1 Inanufaci -ire i i i i fvirlcea* I Su rf 1 c a 1 11 nt e( vent 1 on I 21.01.79 1 ( r 1 gl> I |hepatectuay) 1941-1921 |AII type# of(aalntenance nd [Joba on (work (nteraftt-|Manufacture ently |4 Maintenance 1971-1979 Itn VGH Poly | ______________ ( Proceaa * 8S86S0 S$H 6S86C0 S'Sa UFX/AS(. - LANCtOCASt S,l I fllANl K Sliret A LIVER Angtonarcoma Canen - (Review Date: l Jan 19B7) ii 1 - ii ii1 4 I1 ii il { (lUHTWlf AND | NAHE flR | DATE OF 1 1 KFFEKENf.'K 1 INITIALS I RUTH I COMPANY I FACTORY NCI 1 1 i t1 i I1 i F i am e 1 i 1 I 15 IDEP 1 (01.01.37 ] Cliloe 1 | Chlale I St Tone i 1 1 | (formerly i 1 l l w) i 1i i ii i ii t 1 A r <: LH 1 I11.0J.22 l Chtoe \ | St Font I 1 I Chlmle i 1 1 | (Formerly i 1 1 t u>> t 11 1 11 1 11 1 11 1 11 i 11 i 1I 1 n 1 HAS; 111.01.2) 1 Chloe |SC Fona t 1 1 Chlmle i I 1 | (Formerly i I 1 1 V) i tt t t( t 11 i 1i 11 i 11 i 1 u |K l |14.07.4? | Solvay 1 (Tavern tr i i1 i i1 i i1 i i1 i i1 t i1 i i1 i i1 1 i1 tt i I i1 1 1 i1 1 i1 I 6| 7 FIRST VC | DATE OF EXPOSURE | DIAGNOSIS 02.01.)) |2S.09.fl2 I 17.10.41 1 03.01.43 I1 IT.Ot.AB 1 03.04.43 0).09.43 t 21.03.44 s ACE AT DIAGNOSES i 11 1 9 1 to 1 1 _L_ 1 1 11 | YEARS OF |YEARS OF| | EX FOSURE TO I EX FOSIIRE | | D14CNOSIS i t 1 j_ i 1 ii t i1 11 DATE OF D EATH 4) M 1 to 42 1 27 1 1 1 1 1 1 1 1 41 1 1 1 t 1 I l t 1 1 t 34 | 1 1 1 1 1 1 1 1 1 21 1 1 1 1 t 1 1 1 t 1 1 1 l 1 i i i t i i j__ i i i t t i i 21 |AlIvt i i i i i _J 1 34 101.04.83 i t i i 1 i _1_ i i t i i i k i i 1 t i 1 i i i i i i i i i i t | 1 i _j t 14 103.04.43 1 1 1 1 1 1 t 1 1 11 127.12.BA i i i i i i i i i t t i i i i 1 12 i i i HISTOLOGICAL | CONFIRMATION t I J i i n1 U i 1 i ESTIMATED | 1 EXPOSURE | OCCUPATION | LEVEL 1 t ____ 1_________________ 1 n OTHER CAREER HIGHLIGHTS 1 1 (A J____ 1 | OTHER | COHHENTS 1 J (Left Nrpat ect imy 1194) Yea |Htgh-20 yr (Autoclave |Noderate |cleaner U r* l I I 11935-1941 |eutoc1 art (opera!or |t9*2-1982 J ____ 1________________ 1( Yea 1Hl*h-33 yralPolymer 1aa!' |Moderate - |lon Proceaa 1 Low - 5 yr* fHan ii i |Hatntenance i |Worker |J C Contaaaot t Letter of |5 10 19B1 i i i j 1 |Ret 1 red 1 Jan 1979. |J C Contaaaot |Let 1 era of (5 10 1961 and |?} 7 84, l |Health 4 i IS.r.t? Ag.nt| i j 11 i 11 Yea |HlRh - |Autoclave |Other aectore |Ret Ite<f 113 r. |CR 'aner |of St Fona | Cl | .01.7* 1 119 4-1971 ir.ccory 1971- | J C Coot aaaot t1 (1474 (Letter of 11 n to 1981 1t 1 t1 1l 11 1 J _____1________________ 11 21.03.BA lttlgh-11 yra|Autoclave J 1 I09.01.R4 |Lov - 9 yre|Cleaner i*igi.i ti 1| 1i 1t 11 11 t1 1| 1| 1| 1I 1| 1i | He pat ect omy |05.OS.84174.09.84 Ichemot tierapy (for lung* (partial |r eulaaIon. (08.84 - liver |recurrence. I10.B4 - lung (evolution of |the dlaeaae 1i tci CHEMICALS i POLYMERS CROUP UpX/ASt. - LANGKlCASES J4 RANGE JlfCt 3 LIVER AngloaerronabCanes - Review Hale: Jen I9B7) , (.(IIINTKY AND REFERENCE NO FRANCK 19 in 2\ 1 2 13 4 i 1 NAME OR | DA or INITIALS 1 BERTH COMPANY 1 i i ' HAZ i i MS.11.11 AC oeheo 1 1 1 1 1 BR 102.01.21 Atoche* 1 | t 1 1 \ 1 | 1 1 1 Fa 101.10.*0 tr 1 1 1 1 1 1 1 1 111 | || | || 1 |1 111 t ir 1 fi i ii i it ill i ii , ,t ii i ii i ii j ri i ii , ji i ii i1 1 * I6 ii ii i i rust vc | FACTORY l tivosutk 1 DATE OF DIAGNOSIS il it il il 1 1BriRnood 1 07.04.SI i1 14.10.04 i1 it i1 i1 |Brl|nowt i ii mi 17.11.6S ii ii ii ii ii ii ii it i 1 |SEP l i 1 IIH 01.04.14 |Hontluconl i1 i1 i1 i1 i1 i1 iJ III 11 1 11 1 11 1 III ill iii ii t ii i ill ii ii i t ii i ii i ii i iii ii ii i i ii t ft I 1 9 1 in 1 11 11 1 1 ACE AT 1 DIAGNOSIS 1 1 YEARS or EXPOSURE TO DIAGNOSIS j 1 mu of 1 DATE OF HISTQLOCtCAL EXPOSURE t DEATH 1 CONFIRMATION 1 J_ j 1i 1i 1 SI t IS i IS I04.11.SS Tea 11 11 11 _L i 63 i 14 ( J 1 II 126,11.03 i Yea 1i li ii ii ii li li tt 1 l 4S l 17 i i A I1B.04.S4 Tea 11 l1 i1 l1 t1 i1 i1 _L 11 _L J________ III 11 t 1f 11 III 11 III 1 11 1M ii t it i i*iii i i . .i . i i ii iti i iiii ii ill ii ill ii ill ii ill ii i ii ii ill ii ii 'ii i it ^ 986eo ssy 1i n 1 14 1 n 1 14 j i ESTIMATED i EXPOSURE | OCCUPATION | 1 OTHER CAREER J______________ I | OTHER | COMMENTS LEVEL i | HIGHLIGHTS i j i {Autoclave i |Myocardial {Infarction {operator and| 11960.Coronary High |cleaner i t i (bypaee !9ftl. {Letter fro* IOr Contaaaot 13.4,06 | AmjIoc live J_______________ |ln other partatfortal High loperator ant |of factory (Hbroila Iron {cleaner i i i i Jalnce 1946 176.04.74, The 111 Ineaa waa {dlagnoaed aa |preu*abl jr {work related i {on 10.04.74, i (Letter froa i IDr Contaaaot i IOS.04.86 High j _J____________________ 11 |Autocleaner |Ha1ntenance 1 Hepatic teat 14 v*.r. |worker | Ha y 64 noma 1, 1 IHepatlc teat 1 {Hay 06 thawed 1 lebnomal It lea, 1 1 Let ter Iron 1 I Dr Barret 1 f10.07.0ft. J II 1 1 1 It t 1 II 1 1 11 1 1 11 1 1 ii ii i i i i ii i i ii i i ii i t ii i t ii i i ti i i it i i it i i ii i i ii i iii i i iii i 1.98600 Parv 10 GERMANY Sheet 1 1 1 | 1 COUNTRY AMO I REFERENCE 1 NO 1 | GERMANY ( 1 01 | 1 07 2 NAME OR INITIALS 3 TIATE OF RUTH 00.00,)0 00.00,31 01 00.00.10 l 04 | | 1 1 1 | 1 1 1 * 1 1 1 1 l 1 1 1 00.00.30 I Cl CHEMICALS 1 POLYMERS CROUP LIVER Angloaarcoaw Caaea - (Review Date: l Jan 1967) WPX/ASL - LANCl(lCASKS,13 A COMPANY t i s 1 ft i - | FUST VC i FACTORY | EXPOSURE i i i i 7 DATE Or DIAGNOSIS ft 1 9 ACE AT | YEARS OF, DIAGNOSIS | EXPOSURE .TO t DIAGNOSIS A i 4 | Ot.10.lt tt.Ol.40 JO i ii i i A i A I I4.10.J1 1J.01.10 31 i n i ________________ i |ii i ii 01.04.J1 00.03.JJ 4) t ii i i t i i i i i i i i p t i i i ( t:i r 0 i | I4.04.J7 74.tl.14 / AA t ii i i i i i p i i i i i i i i i i to 1 II YEARS OF ( DATE Or EXPOSURE | DEATH J 17 HISTOLOGICAL CONFIRMATION 1 I 1 1 14 i ESTIMATED 1 | EXPOSURE | OCCUPATION | LEVEL 1 1 i i P *3 1 OTHER J I | CAREER 1 HIGHLIGHTS 1 J i p 14 OTHER COMMENTS 12 115.01.41 Yea (HIOSH) | Polyworker i i j n 114.11.11 Yet (NIOSH) i tPolyworker i J _______________ j J 14 110.10.13 Ya (NIOSH) i iriltlng i (peetlcide i J i i i 1 |Reported under loon polywer- (aeroaol canal [with VC p Meat Ion (worker# In i PN10SH Hat ol i 131.3.II. i [Thti ol course i 11 a at r let ly ji (correct. i (However 1 i Iwonder t whether this i loan had high i leapoeore to p (VCH In hla i Plan f 111 Inn i (opera!lonf j 11 11 I1J.II.14 til (NIOSH) 200-300 pj|Polyworker L|1939 vaa i 1 (Clinical but high ftewporary |autocleaner |detal1 a In during 1 yr|autocleaner |lor 1 yr Ipapar b( autocleenert 1 ICokel et at 1 (Vlrchowa Arch P (A Path 19/6 t 1 m P I93-7IU 1i 1i 1i ti Ii 1i 1i 1t 1i 1i 11 > RHANY beet 7 COUNTRY AND REFERENCE NO HAHF, OR INITIALS DATE Of BIRTH GERMANY 05 (H10SH jive* a* C** 06} 00.00.56 06 ( NIOSH ft Lvea aa Caae 05} 07 00.00.12 00.00.it 00.00.17 I '1 CHEMICALS 6 POLYMERS LlVE.1t Anftloaarroaa Case* - {Review 0 e: l Jan 193?) VPX/ASL - I.ANOlOCASHSJh fACTOtT II mat vc exposure BATE or DIAGNOSIS 02.04.60 10.12.7) 16.11.62 00.00.75 11.04.54 11.11.71 11.07.14 06.04.)! ACE AT DIAGNOSIS 38 43 41 IS YEARS OF EXPOSURE TO DIAGNOSIS TEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION 05 16.12.74 Ye* CNIOSH) 13 12 Of.01.75 21 21 11.11.71 (Ml OSH 11) 10 10 11.11.7V n 14 -L \ ESTIMATED | EXPOSURE | OCCUPATION LEVEL | 1 1 I | IG Die*! e ('cheat*try |Iaboretorlan fin the |Techno|Iof(caI (Reeaarch . |Departaent" |(N10SH aar* |*aaiatant (factory (cheat at (which aay be (wronf |tranalat ton) t j__________ I |PVC - Kami|facture (Shift Leader I j__________ |fC H.nu ll.cture and ,.11 mock |lnct .uto|cleaning 111 T' 1(1114-46) IforMan Tech |Pe* 8 fra 1(1167-11)1) _1 | Polywn rltr OTHER CAREER HIGHLIGHTS OTHER COMMENTS |Coni 1raerf I 1 Reported under (non-polfaer- |f aatIon |worker* In INIOSH Hal nl 111.1.77 and 11.78. t don11 11ht nk Ihla la la correct |cjt aaa I flctInn \hj HtnsH. Hie Jaan a*y have Ibeen Invnlved l1n VCH Ipolyaert aat1 cm 11n pilot pi ant Jor In ailn (plant J______________ Z9860 SVU 98620 p*k* 12 CFKHAKT Sheet 1 COUNTRY AND REFERENCE NO NAME OR INITIALS OATR Of BIRTH COUPANT GERMANY 03 00.00.14 10 (HI OSH give <i Caae II 00.00.36 1 (HlUSH Rlvea aa Caae 10) 00.00.29 oo.oo. is (Cl CHEMICALS 4 POLYMERS CROUP LIVER Angloaarrona Cane* - (Review Date: I Jan 1367) WPX/ASL - l.ANCIOCASESJJ FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS 20.02.61 16.06.76 01.01.61 00.01.77 10.10.53 26.06*77 OO.OO.M 00.10.17 ACE AT DIACNOSIS 41 40 47 ) TEARS OF EXPOSURE ,tO DIAGNOSIS 16 II 16 10 )1 TEARS OF EXPOSURE DATE OF DEATH 24.01.76 10 07.03.77 n . 14 HISTOLOCICAL CONFIRMATION Tea ESTIMATED | EXPOSURE \ OCCUPATION LEVEL | LI I I High peaka f!2 fra poly |worher loci 117t auto- |cIae |cleaning (Control rooai M J* I I i I High peaka f 10 jrr poljr- Iwrk.z Incl lift auto(clave |e leaning I I OTHER CAREER HICHL1CHTS II 26.06.77 01 1.7J T*. High x I |3 yri auto- (clave (cleaner 113 yre |f1Iter (operator x I |PVC Mami- |I.cturc |AutocI... Iwtker for I* ft* I OTHER COMMENTS in/; s Conf I med Average enpoaure fI rat 3 fra 15U pi-, occ 100(1 p|. Next 1 yn #vt 7 5 ppw. Last. ft av IS ppw Average eapoaore IIri 3 )rre ISO pf* occ I OfMl ppi La a t yr av 75 ppw. Ctfll letter of 21.04.76 13 FRHAHT lieet 4 CM'M.RY ANO KF.JfiHF.NCE. NO NAME OR INITIALS date or BIRTH fOMPANT GERMANY n 0.00.U ( NtOSH glvea thla aa C**e 11) lb 00.00.l4 oo.oo.li ICE CHEMICALS 4 POLYMERS C LIVER Ann,QtirrnA Caaea - (Review Da 1 J.n IIS?) MVX/ASl. - LAIOlnrASt.S.lH FACTORY FUST J_. VC ere oi nposu*e Uk.N051J 00.00.CO OS.04.78 i*.io.ii oi.io.ii 10.01.Si oi.6i.ii (Lelbach uapeeted ' ASL at M 1975 1apirotoey *98e eo f * ;e at AGNOStS 61 "IF ir 1 * l 10 i i. -------------- n------------ i--n 1------------rc IB | TEARS Or 1 ii ii 1 TEARS or | DAI OF | HISTOLOGtCAL | ESTIMATE!) 1 OTHER 1 EXrOSUAE TO 1 EXPOSURE | 1 i)t ACNPSIS i i JtATH t CONFIRMATION \ EXPOSURE | OCCUPAT ON 1 | t.EVEL i CAREER HIGHLIGHTS i1 i i( 1j ti i i ii ii t i ii ii 1 IB 1 14 |IB.0B.7B 1 1i I| 1 1i 1 t 11 1t 1 1 11 1i 1 1 11 1i 1 t 11 1i 1 1 11 1i i 1 1 1 (Hot an | i 1 1 1 (Angloaarcon* J i l 1 1 |tn hla letter | i 1 1 lof 11 11 t|, 1 i 1 1 1 (Mr Prledel 1 i 1 1 1 |n1d thla mi \ i 1 1 1 fa mt1attenepi-1 i 1 1 1 ItheUartUoa \ i I 1 1 |0r | i 1 1 1 |Spelaerobre* | i 1 1 1 |(a earctnoea | i 1 1 1 lof th* | | 1 1 1 |oaopha|ua) | i 1 1 1 |not attribute | t 1 1 1 labia to VCM A | i 1 1 t (not reeogniaed| i 1 1 1 |aa an 1nduat- \ i 1 1 1 Irlal dtietie | i 1 ~l--------- TT~ 1 I is I21.I0.7B i * | 1 \i I I 1i 1 \ 1i l i 1t t | |i I i 1i 1 if i t i t i i _i_ JAutoclave (cleaner and (worker. |Drier (operator. (Later ehlft |1eader | i fi it t 1 2) | ( l | f 20 ii i it ii ji__________ ___ | Tat ( High |ASL and | IHepatocellular| (Carelmaa | it IAutoclave (worker till 11164. (Leader and loaater i 1 t ii it | | 1i ii 1 I ti ii | t ii 1 | ri ii t( ( t ii ii | I ii ii | I i1 | 1 i1 1i 11 1 i i1 i _j 1 11 11 1H J______________ | OTHER ( COHHKHrs i J______________ 1 1 1 (1" V Seat 11et ter of (30th Jun I960 (enrloalng data (f roe (Mr H P Ktledel (of SC Cheale [t U Beat (letter of |1Uth June 19fl<) |enclosing data (f ron |H P frledel of (BC Chenle |wlthdrawlng |thla caae i i | i i 1 i | i _j____________________ J Angloa arriHia |con( 1 med 109/71. Sum (detail of thla 14 atao caaee i9f nf nk ib (4 17 given In (HRW Report for 1197B |Anglnearcoma (coni 1 ned, Hull del all a (of Itlneaa la 1 nee han-h I 1973 given In (NAW Med Invp (Rep for 197R. |0llf Ffrill (del all a given (In "VC |Aaanc f at ed (Olaeaae- hjr ll.elhaiti and IMaratcllei lUSHI) nJI. Page |i* GERMANY Sheri 5 COUNTRY AHD REFERENCE NO NAHE OR [NTTEALS DATE OF BIRTH GERMANY 17 (HIOSH gives m Case IS) 00.00.17 20 21 TT 00.00.13 00.00.25 GO.00.15 00.00.11 Mzmrn S986E0 IC1 Cl I EH 1 CALS 6 POLYMERS CROUP LIVER Angloearcona Caaee - (Review Deter I Jan 1987) WPX/ASL - I.ANCIOCASKS J 4 7 10 11 11 14 16 FACTORY FUST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE Of DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 01*11.El 14.OR.7ft oo.oo.tl 757TOF ta.io.U oo30T 66 i* U.oiTTl oo.oi.i6 01.01.62 00. L pronounced cItnlcal liver syvtoaa) n .or. so-" TT 16 "IT TT TT IF "TT 20.06.7ft Yea TT IsTTTTTF TT 71. ..TIo" Tt Hetaataatng ASL lk.io.i6 Tea Ha MAglo Endothe1 Iowa of liver with IT iToi.AO Tc Hacaanglo EndothetIowa of liver with Hetaataaea or. r;:rr To. Hrta.t..Ing ASL High Autoclave worker High Aut oc l.vc Worker Aut.cl... Worker High AutocI... Worker Angtoaar curui conf(reed. Annual report of the North Rhine Ue alphaI1 a Medlea| Inspectoral e for 1978 pages 147-177 gives full detalta. Vinyl chloride d laease <11 agnoaeit 07-02-71. OeaophageaI vart tea. Rad I ol ogl ra 11 y confirmed aero oiteolyala. Dr Beache tetter of 11-04-R7 to Dr W G F Ada Dr fteache tetter of I1-04-R2 to Dr V G F Ada High Autoclave Worker and worked In drying ahop Dr Beache tetter of I1-04-ftI in Dr W C Y Ada Ttgir Autoclave Worker Chargehand, subsequentty Foreoan br Resthe letter of 11-04-02 in Or W G F Ad.io* Pafle SCI CHEMICALS i POLTHERS GROUP WPX/ASL - LANG I UCASKS, Jtl . GERMANY Sheet b LIVE* Ang!oasrcoma Caae* { Key Dale; I Jan 19 it 1 1 1 11 1 12 1 1 14 i 51 8 |i f 1 1 1 11 I1 COUNTRY AND ) NAME OR 1 DATE OF | i | FIRST VC REFKKFNCE 1 INITIALS | BIRTH lCOMPANY|PACTOR! 1 EXPOSURE NO t 1 111 GERMANY 21 ( 1 1 1 f1 1 t 11 ino.no.27 t e 1 ft i ms 1 t t t1 1 1 l1i 1 f l 1t 1 1 l 11 1 1 l 1t 1 24 1 1 11 100.00.28 1 A \ 8 I 1969 1 11i 'l 1 1 1 11 | ft A2) 100.00.2) 1 1 oio 1 1 11 1 1 11 1 1 11 | !1 1 1 26 100.00.22 t 2 iT5Ti 1 111 22 1 1 ' 2ft 11 1 1 1t 1 1 i 100.00.2ft 1 I 1 1 liHs 1 < t1 1 111 1 121.li.1i i ) ( t 1 01.10.id 1t 1 t 1 1 1 i1 1 1 1 11 1 1 1 1t 1 1 1 11 1f 1 1 1 1 1 1 11 1 1 1 1 1 19 I 11 11 11 11 i1 100.00.21 1 1 1 11 1 21 t l 1 1 1 2 1 1982 1 11 1 lit t 1 1 11 | 11 f00.00*17 ( 11 11 (110.00.21 l 4 ft 1 4 | 19)1 1 1 A 1 mi 1 1 \7 1 l 11 11 1I1IUK1.1D | ft 1 1 A 1 19)) 1 111 11 A 1 9 t 10 1 11 1i i 12 1) 1 14 i 15 | lb 1 DATE <>^'1 DIAGNOSIS , _____________ L AC1t AT f1 l DIAGNOSIS TEAKS OF i EXPOSURE TO1 l DIAGNOSIS j 1 TEAKS OF \ EXPOSURE | 1 DATE OF OEATH HI. TO- LOGICAL CONFIRMATI ON 1 1_ J__________________________________ 1i i ESTIMATED 1 i OTHER I EXPOSURE 1 OCCUPATION i CAAEER | OTHER COMMENTS LEVEL i i highlights i *J 2t.01.79 1 !U 1 24 1 21 129.09.81 Tea High 1 1 | Ch ml t ry i i i i i (Primary hepatocel1 nr 1 100 ppm) (Worker i (card none; |1 1i (proliferation uf the 1 i lalnualodal cella ultli 1 1i fafnuaotdal erlaats* i IFrtedcl letter 21.l2.Kt,. *1 U.10.82 | ! TOOT 1 54 58 |14.04.74 , St J______Li ___________ t _l_ il i 12 I28.0S.S1 Tea HTgK (Autoclav* i 1 (*100 ppa) 1 Cleaner t t 1 i)ii iit.di.il Tea 1 hT|K 1 |Polyclave |Worker and i J_ i i 1 l 11 t1 11 til.n.si Tea HlgTi |Autoclave 1 Cleaner 1, I Polyworker ti _L i 1, (Prof Eder (Munich) 11ettcr 22.08,81. |Trtedet letter 19.U4.ft5. J__ ,__ ____ |Prof Selnalr (Munich) (letter 22.Oft.ft1* (Filedel letter 19.04.H5 i |Chronic hepatitis, l 1t langloaatoa1 a, a 1 nuHti t <1* 1 t |i (ectaala. Frtedet letter | lt.01.il | !i 1 1 1idi.dl.it 11 1 16 Tea 1 l Higii 1i j________ _L (Autoclave i (Cleaner tlll| 1 1972 t I21.I2.B6. 1Lelbach. |Frfedel letter 119.04.86 ll.08.8S | 41 [__l_i __ 1 11 1is.0A.il Tea Higi J|_P_r_o_c_ea_a_____ 1 i _]_______ __________________________ (Annual VCH arreenlng 1 1 1 1 1* t 1 1 (worker 1942 1 184 {01. tO.60| 1-11.01.84 i (PVC product -| | Ion, i 1 h11 aior i (re*). 1 i i |24.04.fl5r no couplatnt. (no abnormal tty delected. |1970 Iwb-thirda Iftaat reqtoay fur tilrera. (1971 Cdronary thfnptmft1 a 11981 Itaoral |tap 1anj at ton 11984 Puluonary eubitllsn t 1i | and pi europfleunoulit* 1 |i (Landera letlera lft.U9.KS 1 1i land 04.D2.A7. li.02.il 1 61 ii 1 id iis.oi.it Tea Higii 1 _L idieuI nt ry I _J|_H__a_e_n__a_n_g__t_u__a_a__r_k_o_m__a__._________ 07.01.80 1 42 1 (worker I 29 J1 1 25 125.05.81 L-. ( Tea High |Polyworker I 1 (Shift leader! (Frtedel letter 21.l2.fth. 1 (llaeaenRtoaerVuiftA. (Frledel letter 21.U,fth. 10.06.85 | 61 1 12 I 20 iAi1vc 1 T |AutocIave 1 |c1eauer I _J(_ll_a_e__ia__a_n__R__lo__s_A__rk__ti_n_i_A__._________ (Frledel letter 21.1/.Ml,. 00.D4.ft) 1 55 TO 11 1 1 ?l IAl1vc 1 (polyviirker I f ]Au tnrlave ( 1 J llaentA np t n*.i r k onn, (Frit,del let lei 2 1.1.'.Mr., 998690 S'Sd Page 16 CTAf.V 11 1 CHEMICALS 6 POl.lHtKS i.MJMlL1VF.R Angina art orn Caaea - (Review Date: 1 Jan 1967) i.98600 SSd UPX/ASI. - l AHtilOi AM S.M i 11 1 1 commit and | HFFERENCE | WO i 1 1 TALT I t Ji i ( NAME OR ( INITIALS t i i i i DATE or MATH 4 COMPANY i ii i i i | PACTORY 1 1 I 6 PtRST VC EXPOSURE 1i ii i 1 a i V i 10 i 11 1X ii 1l 1i DATE OP 1 ACE AT l YEARS Of ( YEARS OF | DATE OF DIACWOStS 1 DIAGNOSIS l EXPOSURE TO i EXPOSURE f DEATH 1 I DIACWOStS i .L 1 i ii ii >7 1 HISTOLOGICAL 1 CONFIRMATION | it n 1 14 1 1t 11 ESTIMATED 1 1 EXPOSURE | OCCUPATION | LEVEL i i JL n OTHER CAREER HIGHLIGHTS 1 1 _i 1 | | 1 i 1b OTHER COMMENTS \ 01 (On HIOSH a kippl eentity [ 1 at ) 03 01 04 1)1 1 i.o hj.os.u PANSAC 1 Ml r* 00.00.15 ii (Venice ii i 1i i 1i i 1i i 1i 1i i____.______ i 1i 1 | SK in.it.2* HontedlionlPorto 00.00.17 i1 1 Ha rghera i1 |I 11 i | VC 114.01.30 Sotvay 00.01.11 11 i 11 i 1i 11 i 1 i| i 1i 1 1 Fft 120.07.11 ANIC 1 Ravenna 00.04.14 11 i i1 i 11 i 1i 11 11 11 ( i i 1 1 t1 i J1 l1 l| 1 1 1i 11 i 11 11 |C Danes In 119.01.17 11 11 I| 11 11 PAHSAC 1 ]Ktra |Venice 1 i 1 1 oo.oo.tr IV.04.71 i i i i i i i j_ 11.12.72 IG.07.75 oo.oi.ai i i i t i i t i i t i i i i i i i i i i i i l i i i 07.01.81 i i i i t i i ! 18 *1 11 *1 46 l l t l l 1 l X i i i 1 i 1 i i 1 i 1 l i i l 1 i i i i i i i I 1 l i t i i 1 r i X 06 n 31 21 16 i 01 118.04.71 i1 it i1 i1 i1 i1 XJ t1 i 06 127.12.72 i1 tJ1 i1 i It 110.07.71 t1 i1 i1 t1 XJ 11 1 21 fjo.03.ai 1i 1i 1i 1i ti 1i 1i 1i 1i 1i 1l 11 1i 1i 1 j___________ 1i 1 a 108.04.81 11 1I 11 11 _L 1 TYea Yea Tea Tea Yea \ IfVC 1*8 1 |eit,oder | (Primary imom (ay have been ii (pericardium. 1| (Not homo- ii tt ii Igeneooa with (other caaea. | a * JL ( tPolyworker | ii j 1 1* t ** JL i i 1 High |Autocleaner | I97J-9 did i ||B yr. (1911-1 a variety n |6t) Autoclave Jobe 1 (operator | 1 ncludl ng i 111 yr. (1461- PVC packing .1 XUL i i | 13 pr* - II rr - 1 Never cleaned i Very High |Monoae r | utoc1avea. i (operator | See paper by t ** 44 1 r. - 1 Medium |20 yra - 1 CHIAPPIHO et |Non-amoVer. | al Med Lavoro | Co named 4 rr. Low 1 Hedliea-T muh (Aotoela.e ( Vol 6 (1482) (operator i | M> 111-561 (other dutlea| 11 n auapen< - | |lon poly* r*| llaatlon. | 11 |Area Poreaan| (In aaae Oeptl |atnce 1973. 1 JL (Sag eat ruder) (1467-1475 | Kittle |*1 robot. Nn 1 AOL. i i i l 1 1 i j i IS f.KlIo- | Longa lei*'* at (Commercial | (Dept 1976- | 11963 | JL |I Aug IVFH 1 1 J HaI i <m. Hmt i Uvoio 6S p44S 1 9K Further del alia tn Inter from Ur Honteaann of IARC nn April 1t 19R3. Ms., him- Hall uni ami Pundle11 a In Acta Oncologic* Vo I 1 I9CI0 pages - A? KVAH Ill CHEMICALS t> I'Ul.YHKKS l.KlKJK LIVER Angloaarrona Carp** - (Review Date: I Jan I 9A 7> UPX/ASL - I.ANCllHASES.2 I I COUNTRY AND 1 NAME OR REFERENCE l INITIALS NO I I _____ DATE Of BIRTH FACTORY JAPAN 01 I | Tf o( I |H>rJ I I 01.OS.12 Hltaul Toat*u (no coaaant bj Jap PVC Aaaoc) Nagoya _L 1 0 2 ISO 1 I I 02.OR.35 FIRST VC EXPOSURE date nr DtACHOSIS 00,04.53 24.10,7* 00.II,5# 10.0S.7S ACE AT DfACNOSIS 53 37 1 1 1 YEARS OF | EXPOSURE.TO I 10 YEARS OF EXPOSURE DIAGNOSIS 1 1l L ITE or DEATH i ii i i 1 HTSTOLOC1CAL \ n ESTIMATED conn MAT] OH ( EXPOSURE LEVEL ___________________L i .. i i t i i OCCUPATION i i !________________ i 1 15 1 II. OTHER CAREER HIGHLIGHTS 1 i i i i nrm h COHHENIS J__ 111 III II II 22 1 13 in.io.n i Yea 1PVC Aaaoc 11 3 jrra 4 ito-| 1 11 |eaya not (clave | 1 11 1 11 1 11 Ifcnown. |4 Japan ITtaea IcU.ner | im* - t (assigned * 0 | 1 11 1 11 1 11 |Indicated (different Ion 13.10. 73tvork alnce (had III | | | 1 tt (often at (health | 1 11 1 11 (3000 ppa Pl Lto 1974 1 1 \ _J1-- ____ 1____________ _l1 1 (1 11 1 17 1 1) ti0.flt.7fc 1 Yea (Hot known (In polyner- | 1 11 i ' (laatlon uorfc| 1 tt | (Including | 1 11 | (autoclave ( 1 11 i tclc.nlng | J___ _J1 i _Jt _ (Japan Tinea Hi. in.7fc fc |Japanese PVC (Aaaoc letter ol 3I.03.2S 1 1 1 i t 1 1 1 (Japanese PVC 1AaunctatInn 11et t er ul 111 .(11. 7fl l 1 * In hi a letter of let April 1962, Or Honteaeno of I ARC aaya Japanese HlnUtry of Labour give Date of Hlagnoala - 71-06-74 Age of dlagnoala - 52 Yeara of exposure - 72 898680 SSH 698690 SH Pa Re lS NORWAY LIVER Anglosarcona Oaea - (Review Datet t Jan 19AJ) UVX/ASI. - l.ANCloCASKS,/ I 1 5 16 R 1 9 | 10 17 | n u COUNTRY AND 1 AEFERF.W i 1 NO 1 NAME OR 1NITIALS DATE OF 1 BIRTH 1 1 COMPANY t 1 FIRST VC i DATE Or t FACTORY | EXPOSURE t DIAGNOSIS 1i ACE AT i YEARS%PF DIAGNOSIS i EXPOS tr TO i DIAC.^S.S YEARS Or i DATE OF EXPOSURE DEATH i HISTOLOGICAL CONFIRKAT ON ESTIMATED 1 ( EXPOSURE I *> CUPATION 1 LEVEL 1 1 OTHER AREER HICK!ICHTS In OTHER amnuns NORWAY 56 22Ot | All 73.12.15 Morale Herojra 00.01.50 | 21.11.71 21 104.01.72 Yea Hyd ro Forcun A Autocl.ve ii|tervl .or | | | 1 1 1 1 l 1 1 1 ! 1 1 1 fConf1rnetl by |Dr Ihl1a(Evanaen nf NH, | At APHE htK |9 June 1 9 Jfl (Hr P Ran|tien latated dial AH |had Hern a (nenher of a latart-up lean, |VCN 4 PVC were lead* In sane IbuMdln*. lhe |VCH wee made |f ru* acet ylenr (Cl CIlLHI CALS 4 PULYHhkd LIVER Angiosarcoma Cases - (Review Date: 1 Jin 1987) UVX/ASL - LANi;ifK'AStS,M OUNTRT AHU KFTF.RENCE HO HAKE HR INITIALS DATE OF BIRTH COHPAHT 10 14 FACTOR* FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS TEARS OF EXPOSURE TO D1ACNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL COHFI RKATf ON I ESTIMATED | EXPOSURE f OCCUPATION LEVEL | _______________ 1_________________ OTHER | CAREER | HIGHLIGHTS | _____ I I DIMM COMMENTS 23.Q6.27 | Kemanord | Sundive 11( U.Ol.St | 20.10.70 43 19 IS 20.10.70 Yea XX XX oi 7 7.11.(1 | Konord fSundixllI 00.01.45 I 00.0t.71 IT IT 14.08.71 111- 10.06.10 | Kemanord |Sundiilt[ 00.05.47 f 18.03.76 63 29 1 04 | AL 11 11 1 i i 1(6.11 |4 | Kesanord |Sundays]1| 00.00.46 | 12.09.77 i 62 i 31 1 1t it i t i 1 Ii ii i i t | |I it i t i | 1i ii i i i 1| ii t t i 1 li ii i i i 11 i< i i t i ii ii t i i | Ii ii i i t t 1i ii i t i 1 I1 ii t i i |( |1 II i '______ i i _JL_____________ l i i (1.01.18 | geaanord |Sund.ll| 11.05.44 | 11.11.80 14 19.03.76 i i1 i u 111.05. 77 | i 1i t 1i i 1t i 1i i 1i i 1i i 1i i 1i t 1i i 1t i ti ii i ti 14 31.11.80 Tea High | Polywo rker J_____________ IVCM {production High X I | Roly worker i t High 1 1 1 1 1 1 t 1 1 11*44-1558 t | Ipoljra.rjlaatlon I | iHotk.r (11 | lift.) 4 1*58-1 (1977 foreaanl 1(1* rr.) 1 11 11 t 1 1 1 .1 High - 11 11 11 11 -1------------- ^--!-- 1 (1964-1970 4 r Low 10 Years Icentrlfuge (operator 11970-1980 |drier (operator J_______________ x (Hr SJoe11 n* n /letter of 12ft March 1978 |confirms RL (wee iQfliiaer Iworker who w JbeavlIf |enposed, (probably even (nre ao than |s normal (reactor (cleaner j____________________ 1 |1n first (2 lyre of ` (employment had (been heavlIf leaposed. In (1974* liver |abnormal 11 y (and necruals Idlagnoaed. | Dal a conftrmed (In Dr 0 Byren lletler 18.8.77 |!o CEF1C r __! |Letter of 12nd Hiv 19HI I f ro* |!ir David byrei* 1 I 1st April 19821 IM Hontesaim of IARC aay* In Sweden's Hath 01860 S5*y )?-70 a date of diagnosis for Case U1 and 15-05-72 for Case 07. U86E0 S^H I ,AL 2Q UK Slieet 1 lu ( nu,im*,n,.'> 1,1mm I,IVER Angiosarcoma Cases - (Review Date: I Jan 19B?) WPX/ASI. - I AN<: I lCASKa;, is COUNTRY AND REFERENCE NO KAHE OR INITIALS DATE OP RIRTH COMPANY PACTORY first VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS 10 YEARS OP EXPOSURE DATE Of DEATH HISTOLOGICAL CONFIRMATION n 14 -lL ESTIMATED 1 EXPOSURE | OCCUPATION LEVEL 1 _________l__________ n OTHER CAREER KtCNLICHTS OTHER COHMtNIS 01 2820*04.0l HI 1Ihouee 04.04.44 03.12.72 71 22 03.12.72 (Poa 4 ( Poa 4 Collier Col Her paper iiji 23.12.72) paper e*r 7: *2.72) 02 I 300 ppa H944-7 VCM (1947-8 Orlei 11948-61 lAutoctire (operator 11961-66 (Drier j__________ Lee and tlsriy Lancet 29-06074 pages lllti-A Dubious fabrication case 0003 02.06.37 tarry 00.02.66 .12.7a 37 09 3.5 24.12.74 High |AutocIsve 1cleaner Etposure 11alt ed in 2.66 - 9.69 ItJSR 21.06.20 1CI HI 1 Ihouee 26.04.54 00.06.79 59 25 12.10.79 Hedlu high 154-5 IlMtW |PI ant 155-6 (Drier Plane |5t-58 |Autoclave |worker 150-61 (Chargehand (Drier I Plant 161-72 |Poreaan |C 2/3 plant Pre-war flab packer >r.r vehicle alntenance liii-ii fish packer I 1 1 ( I i 21 l UINTA* AND -f FKRfrNCE HI) NAHT. OR tNCTlAl.5 DATE OP BIRTH 05 JK 10.01,14 1911 I 07 RCA 26.0i.20 ar oa.ni.2i 1i Rerry larry U rry larrf 1 ci client cals t folyhkrs croup WX/ASl. - LAWiinCASKS./b LIVER Angtoaarco** C-aae* - (Review Date: 1 Jan 1 9B?> 1------r I 10 ni 12 vcfirst exposure DATE OF DIAGNOSIS ACE AT 01 ACNOS I S TEAKS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HtSTOLOCtCAL CONFIRMATION 08.0l.il 00.10.2V Si 28 21 8.11.7* T5IF oi.01.80 TVJ=' IF ov.oi.ao -mr bd.6t,.i6 'W "FT TTT J.0 .80 TOOo 2*.II.81 TT TT 2i.l2.il I'. ESTIMATED | EXPOSIIRF. | OCCUPATION LEVEL |________________ I imi-si |Folycleaner 11912-55 OTKKR CARFiKR HIGHLIGHTS 11951-40 1 palyfloor 11940-44 iroir lOurfehand (1944-70 |Charging 1operator | 1970-72 |Drier (operator if Tr* ffoly Floor (Operator 15 yra (Greater on Ifoly Floor Poljcl.intl 11861-S |Xcovty 11861-1871 _L ivio-ma t 1910-il loo pr- (Autoclave 1868-1924 loperator 200 ppa 1 1951-1957 IChargeoan 1 autoclave (building 11957-1974 (Shirt I8ii-i848 Hotor Hechanlr 1948-1950 Operator on Acetylene frodurt ton Flant |aupervlaor 1 autoclave Ibulldlng - I Never (cleaned |autoclavea |but (aupervlaor'a (Job entitle lent erlng (autoclave* | to inspect Ithn. J_________________ OTttFH COMHKNfS 2Z860 SSfcf Z860 S$H I**-* 22 UK Sheet 1 101 CHEMICALS 4 POLYMERS CROUP LIVER Ann t otar ram Canes - (Review Date: l Jan (907) VPX/ASL - I.ANC INCASES,? 7 1I 1 COUNTRY AND | REFERENCE | 2i t NAME OR | INITIALS | j DATE Of BIRTH HO UK 09 i i icicp i io;.os.i5 l i i l l i l l I i i l in I CjT t 104.04.47 I 1 i 1 1 1 1 i i ii 1 11 (CLP roa.0s.2a ( t 1 1 ( 1 1 t 1 1 1 1 \ 1 i? 1 -IT 13*.01.17 1 l 1 i 1 1 1 1 4 COMPANY BP BP I5 1 i \ FACTORY i i IR.rrjr 1 1 1 1 I 1 1 1 t 1 1 1 (Barry 1 1 1 1 1 1 1 1 1 1 6I 1 FIRST VC DATE OP rifosune DIAGNOSIS 6 ACE AT DIAGNOSIS . ______________________ 13.02.50 02.03.83 58 9 1 10 1 11 YEARS OP | YEARS or I DATE OP EXPOSURE TO | EXPOSURE | DEATH DIAGNOSIS 33 . 1 29 )2*.07.83 1 1 27.0*,6b oi oi a* _________________________ 37 IB 1 4.2 116.05.84 1 1 I ________________________ j BP ICI t B.rry 1 1 t 1 1 1 r i i i i i i i \HI 1Ihouse i i 19.12*03 I6.0V.17 02.06.85 07.06.85 37 48 if \ 16 102.08.83 2B I 28 106.12.83 1 \ 1 1 1 12 1 11 t i* 1 15 1 11 HISTOLOGICAL 1 ESTIMATED | OTHER 1 CONFIRMATION f EXPOSURE | OCCUPATION 1 CAREER | | LEVEL j 1 HIGHLIGHTS ( ii Yea | Medlua |Polyworker |2 yeara on | (Acrylonitrile f 1 Reain Plant. | (Alto prior to | |1950. 4 yeara| (RAP | (aalntenance. ( |5 yeara aotor | (car palntahop.f (2 yeara in | (Craving Dock. | 16 OTHER COMMENTS Yea Yea ii 1 IHIgh - II 1 Poljrcl eaiter (Heavy gnode 1 (Information (onttia (500(1966-67. |vehlrle drlvertglven In IPP*). Lou -(Sprey-drl ;r (until final 118 aontha Ik.gger 1* T--(Ilinea. 1(50 ppm). ten. t (Medhat - | Blow-down | | 2 1 aontha |at ripper i 1(200 Ppa) (operator i 11968-70. i (letter |I8.D6.84 Ihhi |Dr D H J (Ullllaaa i i i ii ii IHIgh 1 (Polycleaner 1 - I |Let ter of 11965 -69 |Med 69-79 |Low 79-82 t1365-68. | |Service 1 (operator | (68-69. 1 t foil I (Operator | 169-79. | (Leading Hand! 104.06.85 (Dr Paul Sal tli land letter nf 104.06.85 |Dr It H I) Ivaiu |Oesophageal (hseanr rhsiie (due to 179-82. | loeaophageal 1 (va rl rea due <.. | 1AnglniarruiM 1 |o( 11ver 1 11 i Yea 1 Low 1957-59|Spare unt 1- IHIgh 59-74 lagging | (Low 74-05 |floor 1 11937-69. i (Autoclave i (Operator 11959-85 1 i i t f r | Letter I26.D6.85 (Or E 1 lee i i 1 i i t H* 25 IC1 CHEMICALS A POLYMERS CROtJP LIVER Ang!oaarcona Cate* - (Review Date ; t January 198?) PLASTICS DIVISION WPX/ASI.7 - I.ANCIlirASKS, l I 1? 1 1 i 'L _L_ I OlINTRY AND | NAME (JR | DATE OF I A t s I6 I 1_ | 1 7 1 ft J1 1V I 10 t _1_____________^ " I 12 i ii i i i* i i i 1 | |YEARS OP | v tHU <0- i i i imst vc lOATt or |ACE AT |XPOSURE JYEARS OP| DATE OF I LOGICAL |ESTIMATED! 1 13 I 1 I0THER KEERENCE 1 INITIALS) BIRTH i COMPANY t rACTORT |EXPOSURE IDIACHOS1S |DIAGNOSIS)TO 1EXPOSURE1 DEATH |CONFIRM- 1 EXPOSURE (OCCUPATION |CAREER m ii 1 i i i I 1DIACNOSISI | I ATION |LEVEL IHICHL1C11TS ii _L j J J11 - 1 J J________________________JL 16 OTHER COMMENTS UK iKt 1(12,03 aa lip 13 r i I 1i Ii I I 1i ri l I ii 1 fit rtf 1 IM 1 Jan (1 1 37 1 is i i I07.na.ai i r* i Hl*h IPolyclean* r|Moved to }Realned well, working actively, tint 1 1 1 1 1 it ii 11968-49 fAcrylonl- |Jen 1986 1 1 1 1 1 ii i i Lom (Cent rat Itrlle | 1 1 1 t 1 ti ti |Depot triant | 1 1 1 1 1 ii ii 11969-70 (until left) 1 1 1 1 1 i i i i High I Polyfloor |RP 1983. | 1 1 1 1 1 ii tl 11970-71 {Manager off 1C 4 SS Ltd t Cardiff Ai rport 1963-84 PZ86C0 SSU g860 I'ARC 21* USA Sheet 1 h:i chemicals t polymers group LIVER Angiosarcoma Caaea - (Review Date: I Jan 19B7) UK ayaten of dat ea DAY - MONTH - YEAR UPX/ASL - LANCIMCASKS , 2H - .6 10 COUNTRY AND REFERENCE NO NAME UR. DATE Or INITIALS fltRTH 01 Ea> 1 17*10.23 Parka 02 r f13.08.33 | RFC i 11 I 11 i 11 I 11 i 11 0} |Edward 1?1.01.11 | RFC |01nwlddle 1 1 1 11 1 JL Ot 11.01.1* ire FACTORY ritsr vc EXPOSURE DATE Or DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE Of DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS -L OTHER COMMENTS Lout a- 09*12*46 03*03*73 49 24 21 03*03.73 villa 1 *oula~ *111. | ,oula~ vitle 1 li.ll.il | 00.05.JO t1 11 11 11 11 | 28.11.45 | I3.I2.J3 |1 11 LL | 1 1 1 L 1 | 1 1 L 3? 1 1 it i 13 I2J.03.JI | i |(KIOSK | 1 i i*r I t t |28.03.Jl)| 1 1 18 1 26 1 1 i _JL_ i 11 i 28 II3.I2.J3 | i 11 t 11 --L_ ___L_ _Jl_ Tea Tea ( 1 1 1 1 1 | I 1 1 Pot Cleaner (flock Jaii 1974) p 5 Hlatoff Riven (Rolling Slime In Anna]* NY (Art ACAD SCIENCES I Ref I NY Acad Vot 329 (1979)|of Sc Symp page 190 In \ 1974 Paper by 1 Alao f1 urk 1 R Cottlne of|Jaa 1.7.74 OSHA Ip S3 1 Pot l<C( 1 1 1 1 irot l(cl 1 1 Cleaner i Slack) i i i j 1 Cleaner |Loutav1L1e Block) |Court er tJournal 102-09-60 i____________________ i IRef | Al ao Stock IJAHA 1.7.74 IP 53 _!_____ | Ref 1 Al ao Stock 1 _J_____ Lou 1 a - Ot.OJ.il If.OS.tJ 43 13 13 OJ.OI.t8 Ttl *111* fot Cl.n*r (Cf Hock) I Kef t (Alao Block 01 Ii.OI.lt arc Loula- I3.0t.44 03.0t.tt 12 20 20 03.04.tt Tt. *11 It Bar Auat In Joneaf 73.11.26 Lout avtlU 17*01*62 00.07.74 4S 24*07*75 OJ Char lea 03.05.27 T Smart S Charle aton 27.Ofl.44 00.00*66 45 24 23*03*66 06.09*20 Goodyear Nl agara 07.10.46 00*06*61 41 ts 29*06*61 fot Clttntr (Cl Block) US Air force fot Cleaner (Cf flock) I 1 Bcf I lAtao Block J_______________ I IRef I * 1 LouIav111e |Tinea 2).7.75 1 Ret 1 red April 11974 |Alao Block J____________________ | Ref I IRef I t,lCl CHEMICALS POLYMERS WX/ASL I - LANCUiCASFS. 25 UK ayetem of datca LIVER Angtoaareona Cane* - (Review Date: I Jan 1987) DAY - MONTH - YEAR 10 12 11 t A IS mr AND PENCE JO KANE OH INITIALS DATE OR 81RTH COMPANY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS Of EXPOSURE TO DIAGNOSIS ' years or EXPOSURE DATE or DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS f OTIltR COMMENTS tf unionH OB.ft.il RFC au1- 28.05*45 01.03.7* A) 29 24 1.03-75 Yea /000 pp O tU- villa Finger? f |ReJ I hae (wrong f 1 gurea |re 11rat | exposure, |Loutevl11e |TUm 129.10.74, MT.i.n. I 10.1,76 16.00.11 Coodyeer Niagara 12.06.51 00.05.60 55 17 17 10.05.68 Yea 27.05.09 Goodyear Niagara 14.10.46 00.01.70 61 21 23 16.03.70 Yea I | Ref l J_____ i l*.f i J_____ I ? Francla A 17.11.18 Ft reatone Pottitwn 13.07.49 02.05.69 50 20 19 02.05. Bachaan Fa High 10 fra 10 yrt aa Utility A |He f l fetter reactor op. Service op, fof 76 April (not cleaner Bagger 11978 from - aeparata Dtyer op. (Ruaaelt A Park crew cleaned Stripping op. 11o J T Seawell autoclave*) 3 yra prior |cf MCA aervlce In l tyre plant | _________________1____________________ 11 Rlcha rri 01.*2.21 liCC S Charle 11.12.42 0X0*.`| * 52 32 76 07.04.74 l Yea 2000 ppa Edward ston Clendenln |Charleaton |Dally Malt 121.7.75 I (Never dtag1noaed ax anglloaarroax of II Iver. Infnim|at Ion given In (letter 27 Hay |1964 |rnn I) A Salg. J___________________ | Arrmtnt h nl ; |ASl. - Hu rvl - |d i-itrn nl VCH | r i (him n r <. I_____ ________ 9Z86S0 S'SH 2.2.86E0 SSU PRr 26 ns Sheet 1 ICI CHEMICALS 4 POLYMERS LIVE* Angiosarcoma Cases - (Review Date Jen I raft 71 10 UK. System of date* DAY - MONTH - YEAR WPJt/ASI. 2 - i.ANUHn:ASES,t 11 14 15 1h COUNTRY ANO REFERENCE NO HAKE OR INITIALS DATE OF MATH rACTORr FltST VC EXPOSURE DATE Or Of ACHiVtS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DeATH HISTOLOGICAL CONFIRMATION ESTIHATED EXPOSURE LEVEL occur vn on OTHER CAREER HIGHLIGHTS rmim COHN*NTS I A Jane* 04.11.37 arc Inward xiutavine 08.05.50 00.00.69 41 19 17 Peerenboo* 06.05.31 arc b4Mlisvilla 23.06.55 M.10.74 45 19 1 11 Ifl |Charlie 132 04.28 1 RPC 1i i 1 1 | Avon Lake) IS.08.J8 t 00.00.7S 1 8t 1 21 |Arthur i i ii 1 1 1 1 1i ir t 1 t 1 i ii 1 1 1 t 1i 1i 1 1 1 || I r1 1 1 t J ii tt 1 1 1 1 i i__________ i ____ L 1 _J___ 1 19 Virgil 00.00.15 Christ 1 an S Charle 00.00.43 ston 19.06.75 60 33 ?0 11.08.17 Goodyear HI agara 00.00.55 30.01.76 21 Hi eater 02.09.09 UCC Hinkle S Charle- 00* 12.46 aton Early 77 58 67 30 04 27.03.69 16.10.80 tea on lt.IO.74 but no post-norten 16.10.80 1951-4 1 CM pol jnaeitaatIon I t From 1954 |Table 4 In oiwirdi In |UaRoner Amy and other|Teat loony ti service. |US Senate 46-50 Aroy | Coni 1 med I it |H N Johns nit |1tr 07.DA.7B J__________________ |Or N U Johnson (letter of I 24.2 .A I rnn| f t med death |6 year* alter ti t IS 102 11.75 | i i1 r i1 i i1 i i1 i tI i t1 i ....i_ 1 32 06.04.76 Tea 18 30.01.76 32 02.01.77 i 111 rr. i IN.., (autocleaner | 18 jrr. on t Itatol |Tyre Store IplatIclser| (4 Carboaet | (operation | 11L 7000 pps ii 1 f Coni t med 1 *< | |H N Johnson 1 111 r 07.0B.7R | |AIso Roll1ng | 1 St one nag. | 115.01.7b 1i ___________________ t___________________ I | W11 H ana pr I |Sun Caret t * | 2 I June 1 97 S 1 Char Iea t un |Da IIy Halt 171.7.75 j__________________ IN10S11 l ell *t |of 75.10.79 -L 1 12ft yra with liter ai SC |Ret 1 red | News rele,iN*> 121.2,77 j_________________ tC| OfKM l CALS 6 POLYMERS GROUP n WPX/ASL 2 - LANCIfiCAM S , UK ayat em nf datei LIVER A/tftloaarcoma Ca*e* ** (Review Date*. 1 Jan OR?) DAY - MONTH - YF.AR 11 \ 1 1 Intry and IfEHKNCK 1 NO 1 J | 1 i t 1 72 l I 1 t i i I l 1 ? NAME DR INITIALS 1 i 1 l I 1 I 1 r 1 31 i i i i 1^ t (Char tea t Mv. rd |Honre t | 1 | ) J 1 I 1 | I 1 1 1 --nvr I 1 I 1 I I ( 1 13 1 1 4 1 t *> 1( 11 | DATE OF I | MATH 1 COMPANY 1 i i 1 FACTORY l1 i ir s1 i i 1t 102.10.23 ( RFC | Loti 1 a - it im 11 1 ii 1 11 (! fI 1 1 1 ii tt i ( 11 1 ii i ii 1| i | 11 ( it i ii i 11 l ii i ii i ii 100.00.2) I Great | | American l |Fitchburg (Hate. f 1 Ghent cal | | Company IIM5.D } ucc i ($ Chart* 11 I a ton 1l i tl i 11 i 1l i 1l i l1 || t |t i 11 i 1 1 11 ll 1t i i i i 11 1 i1 1 ii 1 1l I j Ri*m<iva1 ItoH reglater nir ii it 1 l 6 FUST VC EXPOSURE ll.0J.t7 O8.0t.SS rtrt mail In R 7 DATE OF DIACMOSIS 00.01.78 06.0t.jj iJ.di.JJ antnahl le t 11 ft t t L in t 11 1 11 j 1t 1 \1 ACE AT | TEAKS OF 1 years nr ( DATE OF | KISTflI.OGICAI. DIAGNOSIS 1 EXPOSURE TO | EXPOSURE 1 DEATH | CONFIRMATION 1 DIAGNOSIS ii l i i. i ii si i h i i t i i i i i i i i i i i i i i i i 50 t IS 1 1 60 1 3ft i i i J i i i i i t\ i \i | i '. i i 1 1 1 4*r tif 5 Nvemher 1 1 ISBO t 78 104.12.7b 1 Yea ii ii ii ii ii ii ii ii ii ii ii <i ii ii ii ti ii ii ji t It 106.04.73 | ii it Tea ! ut |lj.04.jj idiol.nglo- lOHOSW |<*j. 16) | 1 | (aareon* |(1 KamtnaM | 16/7/78) 11 11 1< ( ~J 11 11 11 11 1 t" 11 11 _J1 11 11 11 t1 11 11 1 i n1 i It 1 11 |1 ESTIMATED | | EXPOSURE | OCCUPATION | LEVEL J | 11 \1 14 OTHER CAREER HIGHLIGHTS 1 lb 1 \ OTHER 1 COMMENTS i J______________ Hedturn to Mgh for 24 yra ~ ii ii ii 1| (LouJav(lie (Time. 2b.1 ,7h |ald he was (the 1011. AS |vlrtIn at ii ii ii J ft*11 a Lane nl |whom ft h ad Idled by ii ii ii it ii (2b. 1.76 |tn hi* letter (of (6.09.ft 1 (Or H N Jnlmaon (conf1rma Mil a ii ii. *it* ii ii ii (caae described |by Oannaher (Tamburrc* 4 Yam ii (In Feb IVfttl it (Am J Medicine j1 | Vo 1 70 p2hf) ii i it 1 ii i 1tttl-65 non-l)4)7-4t wo. (solvent |off and on (vinyl realn |labourer (unit and IJ939-41 may i (N H Vhee1*r (letter nl |lll.ft.J 7 t n | J Stall or d |dl*peratin (have been (vinyl realna(eaposed aa |g1ves deta 11 a (Rose fcamlnnV.1 (unit llrat |ractor 11et1er nl 176/1/J8 [helper, then|1943 became |R Kant nab 1 liMft HMft fitter 1(4 Hov 188(1) (utility man 11946 became taunarata thai | (ahlft ut111ty (NI0SH w|If 1 (nan (retain on 1 (76.04.63 | reg 1 at er m (in r | |employment wa*|th)a neoplaam 1 (terminated (may he ntfHm t- J! l1 (ated with ASL. (ft N V^eeler 11 (letter nl 11 |20/7/79 and iI tI | Hnse Kami isA 1 J1 et t i*rs< of iI | 76/7/79 .m.hI 1 1 4/ 1 l/Htl s1^9Z.86 (-88600 SSH r**e 30 USA Sheet 7 tCl CHEMICALS 6 POLYMERS GROUP LIVER Angfovarcona Cases - (Review Oate: I January 1987) vpx/asl? - i.aw:iik:asfs(i, UK ays t en f date* DAY - MONTH - YEAR 10 n 14 COUNTRY AND REFERENCE NO USA 17 IS 19 1 11 INANE UR | DATE 0F| IIHtTtALSI mm | COMPANY 1 11 1 11 1 | Hr J 11 129.08.291 BFC |Rayton 1 II I1 1 11 tI 111 ||| 1 11 I t | JWB | 11 1 1 is.oa.niAi r | (Producta i 11 J Kenlee 77.06.18 1 1 | FACTOAT t 1 1 |Louia| vl Me 1 1 1 r 1 1 1 1 1 |Clrt ICItT 1 Paaaafc 1| 1 irntsr vc |DATE Or (ACC AT 1 YEARS OP | l (HISTO- II | EXPOSURE | TEARS Qf{ DATE OF fLOGICAL |ESTIMATED! II (OTHER | lEirosute |DIACNOSIS|DIACM0S1S|TO |EXPOSURE! DEATH | CONFIRM'*|EXPOSURE (OCCUPATION 1 CAREER I OTHER COMMENTS l| | |DtACN0SISI ] |ATION (LEVEL ( J________!11!l ) J (H1CHLICHTS1 \ 1 1 1 11 i1 1 t1 1 ITS J (06.08.84 1 58 1 M 1 22 106.08.84 | Tea t High |Worked | (Information given tn letter 09.08.84 | t t 1 1 1 1 1 Ir.gularly | |froa Or M H Johneon 1 1 1 1 1 1 1 1 |1n PVC areal 1 1 1 1 11 11 (In the 1 1 t ( 1 1 1 1 1 (early day* | 1 1 1 1 11 11 |w. . 1 1 1 1 1 1t 11 (reactor | 1 1 1 i 11 11 (cleaner 1 | | I 1 ) | 1 1 1 1 1 1 1 1 11851-75. 1 t1 1 1 1 j J J1 1 1 1 1 11 11 ( | 100.02.68 Hi.01.a* 1 61 1 10 1 10 IT8.l0.ai 1 Yea 1 High (Nonaal | 1 t 1 1 1 1 1 11963-198?(progression) 1 1 1 1 1 1 1 1 Jftom helper] (to senior t j (Throebo cytopenle and leukopenia alnce lattice 1978. Cold treatment (or arthrllla 1 1976. Under Or * a care about 6 months (before death, had paused standard physical liiulmttoA 3 months edrtter. J Harr (operator. 1 |1ettera of 21.10.84 nd 21.Ot.85. |c leaned 1 |reactors, 1 1 .tripping 1 (and 1 (recovery 1 (areas ae 1 iv.11 .. t Ich.rging 1 (operator. 1 I960 March 65 24 25 29.06.84 1984 Low j 11 (29.09.60 - |Worked (K*t 86 |before IVInyt 11860 (Never in hoipltil fat any chronic or (ecute Kdlcat problMa. Death certlllrai latatee cauee of death catd(o-pulnonary larrtat aecondary to angiosarcoma of |fabrication!wlth US High irl.nt |H.y 66 1 Aug 70 lUtilily |Alr 1 force. |United |Uool tLetter of 15.07.06 fro* John E Ertel [of Pantaaote with letter of 24.02.06 I from Dr Auerbach, Pathologist. |Rea In (Dyer. (Operator 1 and ((Inc Jul 66|Okanlte Low I- Sep 67 |Reactor (Operator) 1S.p 70-67 (Monomer (Operator (1982-81 (ML (1 (Operat or, | Ca I e nd h r | Sh(l|l , 88 01 1 1 1 1 t 1 1 t 1 1 1 I Cl CHEMICALS A POLYMERS GROUP Z71 VPX/ASL 2 - I.AW;im,ASKS. 1 1IK system of date* LIVER Angiosarcoma Cartes - (Review Oatei 1 Jan 1907) DAY - MONTH - YEAR Il 1 12 1 13 t A 15 11 1 NTHY AND EfERKNCK 1 HO 1 | l 1 1 NAME Olt | INITIALS ( t DATE OF BIRTH COMPANY 1 1 | FACTORY t 11 i 1t i 1 33 1 1 I t idi.tn.ji 1 BEG i 1 Lou 1i- |tlt< 11 11 1 11 t Il 1 I1 1 11 1 1t 11 11 1 11 t I1 1 }I 1 lI t 1I 1 1I 1 1I 1 1| 1 1 31 1^ r i i l ichartea |Edward i 100.00.3) 1 1 1 ttj.os.ir' 1 Greet American Oiealcet Company UCC 1 1 ruchborg IMeee. i |9 Oiarlt1 eton lMoore 1 i 1t i 1I t tl i I1 t l| i 1t 11 t 1i t i | i t 1i t ii i ti t --nvr 1 1 I t 1 1 i t l (f 1 l1 1 I J Removal 1 tom t eglster run I1 1 1i l & msr K exposure ll.0J.5J 08.09.5* rm rued In It 7 DATE Or DIAGNOSIS 00.0l.J8 06.04.7) iJ.4i.J7 amt nub 1 le i ft t 9 1 1 AGE AT | YEARS OF DIAGNOSIS 1 EXPOSURE TO f DIAGNOSIS 1 t i 57 t 3 t 1 1 t 1 1 t 1 t 1 1 1 1 1 1 1 1 1 J 50 1 1 1 15 to 1 i i i t t i t i if i 3* i er of i t l 1 i 5 November 1 1 1900 10 1 11 12 YEARS OF 1 DATE OF EXPOSURE l DEATH t( 1 STOt.OGICAt, CONFIRMATION j* 104*12.76 Yee _____________ i 18 108,08.JJ Ye# Ut (HtOSH r 18) J inrof.Tr Cholenglourcoei (t Rem!oakI 16/I/J1) ti tr 1 18 15 t 16 1 1 ESTIMATED 1 EXPOSURE | OCCUPATION OTHER CAREER 1 l 1 OTHER | COMMENTS LEVEI. i t HIGHLIGHTS i __________ J____________________ i 1^ * >. i t 1 Lou 1av111 e t |Time* Ib.1.76 i |aald be was 1tbe 10th AS Jv1ctIm at i |Be|le Lane nt t |whom 0 had i Idled by i 136.1.76 t 11n hie 1etler i |of 16.OS.A1 t | Dr H N Johitaon i Icon!1rma thie i 11 a the i (case deacrIked t (by Daitnaher i (Temburra A Yam t (In Teh 1900 i (Am J Hedlrfne j 1 Vo! 70 pIHO tt i1 i1 Medium to 1lfttl-65 non- i4)Mi u.. 1 IN H Wheeler high lor |eolvent off end nn 11 eller of 18 fra | v!njrJ realn 1 abouter |unlt end 16)9-81 .y |10.0.77 to 1J Stafford (dlrperiloR have been |gIvee del el 1 a IrlAfl reefna eapoeed ee l Rose Rami naV. 1 |unlt fleet reactor 11elter of |a. Otter c leaner )38/2/11 (helper, then 194) became JA Kaminakl |eMf t ehfft litter 1(5 Nov nan) (ut(1Ity man 1944 became laoggeata that i ihtft utility INIOSH will t man Iretalo on i J8.tl8.6 5 | register a line i employment witltMn nenplaxm i ~i t 1 e rml na t ed (may be nuiitn 1 __________ fated with ASL. |R N Wheeler i (letter ul t 120/2779 and 1 | ftuke Kami n-ill 1 1 f 1 et 1 er). ul 1 126/7/hi .nt.! 1 |S/1 l/HII 8i.860 ~-*SE3TS& I1*** 29 MSA Sheet 6 CHKHICAI.S 6 POLYMERS CROUP D LIVER Angiossrcona Canes - (Review Date: 1 Jan 1967) (IK ayat en of dat ea DAT - HCINTJI - YEAR n WPXfASL 7 - LANGim ASKS. COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH US 1? C U Giroux 21-01-06 FIRST VC EXPOSURE DATE OF DIAGNOSIS Sprtnfflei I5-10-51 Hat a 00-07-79 us n S Ferguson 06-10-27 Jnr US 14 Hr Byru 29-01-14 LoulavtIle 09-09-54 11-05-62 Loulavl11 1955 01-11-62 US 15 M . 16 09-01-12 S Charle 21-07-44 ston 16-07-63 77-08-12 The Genera 1 re and Rubber Co Aaht ab Ula I |-06-e6 2 -06-61 086o ACE AT DIAGNOSIS 71 54 46 71 50 TEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE 26 14 (In PVC autoclave area) DATE OF DEATH 7-05-60 HISTOLOGICAL CONFIRMATION ESTIMATED l EXPOSURE | OCCUPATION LEVEL I 1 An autopay vaa done and t The death 11940-1951 cert IfIcat e|Vartoua Jobs (Mediate *a*a fin polymer cauae of Nr Giroux' loanulacture death given aa ' Angiosarcoma* usual | BlfTVAR oecupatIon LUSTREX aa *kettl e|1951-1964 operator* (Various jobs I n |ln and Vhralct la leround PVC 1 nduat rj", |autoclaves |1964-1971 1Varloua |c1erlcal |)e a In PVC Ipoiynarlaati IfacHlty/ |Ret I red 101-01-73, OTHER CAREER HIGHLIGHTS 26 26 Alive Tea iHultlple 1 )ob# | Including I Poly (Operator 4 (Polycleaner. 27 10 04.06.63 Tea I IPoly (Operator 4 1965 left to becone (Autoclave Clergyman. ICteaner 1 1955-65, 1 39 14 16-07-6) Nigh 1944 from to J______________ I | 1 1955. | Med Its* frnis| 1955-1958 | 27 27 All/* ' Hnderate (1956-56 11abourei 1 1956-57 (prod helper (1957-70 (operator 11970-75 le1ert r tc tan | 19 75-preeent |operalnr J_________________ (lTMi.M CttHHFNIS Infornat1nn gI wen In letter ot iU February 1962 fro- Dr Valter C Barnes ol Htmsant o Springfield in Dr A ttnnn nl Hnnaanto Europe, Prof Tanburru letter ol 17 Aug 1961 < Dr H N Johns.i 1etter ol 26 Teh 1961, Dr M N Jnlitian letter of 1 Nov 1962. 26 Feb 1961 and 9 Aug 1964. Ur Decry letter of 5 Sept 1961. R W l.anndr I letlei of 17 Sept 1VH (: apntled at mrtl I ca I Hay 1961. Teat Ing i Mftnrm i>.t H.* y I4rtl 6Z.860 P*R^ 20 USA Sh<et5 ICl CHEMICALS A POLTHERS CROUP LIVER Ai.gloaarcoem Caaae - (Revlta Date: 1 Jan I960 UK a)rste of dates DAY - MONTH - YEAR IfPX/ASL 2 - LANCl ((CASKS ,*4 i 1t i COUNTRY AND 1 REFERENCE | NO USA t 1 i NAME OR INITIALS 1 DATE OF BIRTH 36 (John Berry ftf.07.11 f \ i i l 1 i 1 1 1 f i i 21 U 1. I.OS.It |Fnr reat t i i i 1 i 2% i 11.04.1) 1 i 19 t 12.10.07 i 1 JO | UVH 1 1 i i i i i It 1 1 1 1 1 1 1 1 i i i t i 22.02.21 oe.ii.2) t A COMPANY 8 FT, 11 1 51 6 11 | | 21RST VC | FACTORY EXPOSURE i i 1 |Loots- IvlM* i t 01.10.47 1 ii ii ii it ii ii it tt ii ti ii tree UCC (S Charl*-| 01.02.21 \ Itofl 1 11 11 11 11 11 11 |S Ch.rl.-t | aton 00.OR.24 UCC |S der!e-| 00.05.42 \ aton 1 Tenneco ii 1 1 . .... (Fle*lngton It.08.44 Cheatcals i i ii ii ii it ii UCC ii IS a.rlc-l 12.OS.46 t aton t ii ii ii ii tt ii ii ii ii 11 11 t1 ii i 7r DATE Of DIAGNOSIS s ___________J M AT DIAGNOSIS 1 91 YEARS OF I EXPOSURE TO | DIAGNOSIS j 1 ii i ! 14 1H 1 12 t n yearA of 1 1 l1 | LATE OF | HISTOLOGICAL t ESTIMATED 1 EXPOSURE t DEATH | CONFIRMATION | EXPOSURE | OCCUPATION JL_ | LEVEL j________ ii i ! n *6 _!____________ OTHER 1 nniiH CAREER \ CIIHHLHIS HIGHLIGHTS _J___________________ 1 00,00.77 (up to 2 year* *f c.r death) 52 (death) p Jo.n.JA 62 oTrrnr* oo.ol.Ao 30.I2.A0 61 72 SR 01.OR.SI S7 28 (death) ... JJ 1 ts ni.oi.7i i 1 ii 1 i< 1 ii 1 ii 1 ii 1 ii 1 ii 1 ii 1 ii 1 ii 1 ii 1 ii 1 if _1 1 20 | (RIOSH I25.II.7R | 11 l*T* 17 1 land C 1 1Dilf N.III 1 1 | (75) 1 t 1 11 ir 3R 1* 15 1 1 t t 1 1 1 t 1 1 f 1 1 t 1 i i i i i 1 i 1 1 1 i 1 1 1 _J 11 101.11.71 | 11 11 14 IOI.01.RO I 11 1t 15 no. 12.so i 11 11 tI 11 11 11 11 n I02.04.S2 | 11 11 11 91 11 11 11 11 11 11 11 1 >1 _!L Yea Tea Tea Tea Tea Tee liapoaed In IVarloua |oba |R Rani rink I leone degree!In PVC (letter nt (to 22 Iplente froa (76/2/ 79 amt Ichealcala leotd roon to |pro!. Taabuiin (but naln Ipstt* (letter ul (evpoaure (recovery to 19/1/79 |va* to VCH ,|fvc charging |probably loperator to 1 t thi*h 1 i (charging. i 1111 Auguat 1 1 i 11965. | |Ter*1nated 1 | i teaployaent 1 j_________ 1Jan 1966 _J____________ 1 High lOperetor to Eipoaure In JR H Wheel er 1 110.10.76 bulk and |1lr of 4 Jan |1 dlepereton PVC|1979 and 1| anuf ecture J Charleston 11 IDalty Hall 11 |1 J_________ 1 11 (10.lt.76 ami |R ftaninakl 126/2/79 |R fcaalnnkl 11 1| t1 11 et t er of 16/4/79 |R KtaintVI |1 |Lettera of || |19th June I9HH J_________ J_________________ f4 - Unknown[Maintenance If - HI nine!| Mechanic i 16 gra i Itlaevhere (4 5th Nov I960 1 1 1 1 t mi ft. | (Boiler houaef 1 | i lOperetor | |i 1* T" |Hlgh (But Chemical 1 froa 1959 to (Dr Decry |not ee high!Operator In 1976 Al 1 pliat Ir J1 et t er fee reactor (charge |c leaner. I react or |would 1 Jeapertcrire) | |Worked aa | Chenlcel a operator ant (I6.HJ.AI and |R N Wheeler I iota July t97b|letler ! to date (9.1 1.61 a Fortman ) A 1 a u Dr Unify |1abourer 1 Al1 phot 1c (tetter ul | f rn \ |June 1941 1 Chrwlrat Operatton 1117.(1 l.fl l re (date of dMt It. Itu Huy 1946| |anil may i thave i Jr t trailed 1 1 n-.n l urn l 11 lull l late _i__________ 1 1 J 1 _J__ ( :e ?7 t jet 4 (Cl (lit. K( CALS A I'OLYHFKS CROUP L. IVF.R Rnglovarcoita Cine a - (Review Date: I .fan (9fl7) UK eyaten rf date* DAY - MONTH - YEA* UPX/ASI. 2 - LANUI IK'ASt'S , 1 l t1 1 t mum and | ^Terence } NO 1 1 SA 2? 1 1 | 1 | | 2 NAME OR INITIALS | | | | | | J 1 71 1 r i i 24 | Char 1 ee ( | --nw~ | | | \ \ | 1 1 1 l |) 1 1 | DATE OF 1 birth \ t 1 A COHPANY ti i ii 151 t i i 1 o1 9 11 i 11 11 i 11 1 t msr VC | DATE or 1 AGE AT | TEARS OF | FACTO** 1 EirOSlIRE | DIAGNOSIS | DIAGNOSIS | EXPOSURE TO 11 i t i DIAGNOSIS t \ t JL ii 11 |02.IO,21 1 RFC lLoute~ (villa 1 11.07.AT | 00.0l.7t 1 11 i 57 I i 29 1 11 1 ii 1 I1 1 i> | 1t t I I | I| 1 ii |1 | t i | \\ 1 i i | 1I 1 i i | I( 1 i i | 11 1 i i | 1| 1 i i | || 1 ii | 1I 1 ii | 11 1 1 1 I \1 1 ii | 1\ 1 i i f [i 1 i i | ii 1 ii i 100.00.21 1 1 1 liTojTTT Great American Oienlcel Company UCC ii 1 X FItchborgl 08.0.I* | |Hea. | 1 ii 1 i t --rro--I |S Oiarlt-| 06.04.71 UM.v i 1 t 1 1 I i SO I 1 1 1 Eoi IS | | aton | i t i | 11 t i i | 1I 1 i i | I| I i i | ii i 1 1 |1 |1 f| 1 | 11 1 | | .| 1 | | 11 1I ii 11 tt ii 11 i i t i i t1 |j \ | 1| 1 . ii ii 1 ti i 1 ii i i < 1| 11 1 11 i 1 1 11 11 | Ki-n ival lriM register rnnll naeri In R tCanlnnhl letter nf 5 Nnvenher 1990 |1 11 1 it it 1 in | TEARS OF | EXPOSURE 1 29 1 14 1 I ill KNIOSM la.y* 16) 1 1 11 1 17 1 1) J t | DATE OF | III STOCK!TCAL 1 ERTI HATED | DEATH | CONFIRMATION | EXPOSURE | LEVEL J 1 104.12.76 1 Tea 106.04.7) 1 Tea I17.0S.7J | CfrioiangtoInrcMi |( Kaalnikl | 16/1/7*) 1 "* i i i i 1 i i t i i 1 i i 1 i i i i i j i i i i______ (Hedliaa to thigh for |14 jrr. 1 1 1 l 1 1 t 1 1 1 1 1 1 |- 1 1 1 1 1 1 1 1 14 I 15 l 16 | | OCCUPATION \ | OTHER CAREER HIGHLIGHTS I | OTHER | COMMENTS i j____________________ | | Lou titvlllr (Tinea 2 b . 1,1h faald lie wan i | the Kill. AS |vt ctIn at |Be 11 a Lane ot |vhon 9 had Idled by (76.1.76 (In hta let ter tof ib.09.ni [Dr H H Jnbneon (coni 1 rna till a 11 a the Icnee deecrfhed (by Uamtaher (Tanburro 4 Ye* (In Feb 19fll) | An J Hed L-1 ne 1 To l Ml p2Htl 1 l i j___________________ 11141-65 non -1ll)7-)9 urn. |H h Wheeler (aolvent (off and on 11 el ter nf (vinyl renin (labourer | IB.A.77 (n (unit and 119)9-41 .y \J St it Turd |d iaperainrt (hive Keen |Rlvei delnl1 a Ivtnyl reatna(eapoaed aa |foae KanlnaH (unit lira! 1 react or 11et t er nf |aa fitter |c leaner 126/1/71 [helper, then||94J becane 1 ft Kami nafc | lahtft lahtft Mtter |(S Ha* 14611) |ut11 it y nan 1194b hecane leugueata thal lahlft utilll)- |HI OSH wilt tnan |ret at n un 176.04.6) (register si 1 in e |enploynet wae|tMsi neoplasm 11 era!nat ed |nay be asjnu 1 - |eied with ASL. (ft N Wl.eeIer 11et t er nl 1 20/ 2/71 xml | Rune Ka<*l usl. I 11 el t ers. nl 1 ?6/T//*l ..... 1 IS/I 1 /Hit 8V JIINTRY AND NAME OR FERENCE INITIALS r 4 i 5i4 7 18 19 10 1 it | 11 13 14 IS FIRST VC exposure DATE or DIAGNOSIS ACC AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATETM DEATH HISTO1 LOGICAL fCOHFIRH!ATION ESTIMATED EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS KlSLAVl A ' 01 05.04.14 J*o Vlnll Split 00.00,53 OI.OA.73 59 5,11.31 Jugo Vt nil Split 00.00.50 2.07.73 A2 20 0S.04.73 iM 23 10 12.07.73 Te* 11.06.30 Jugo Vlnll Spilt 15.I2.5S 03.09.7$ 40 20 IS 03.09.7S VCN Production SARIC et il paper Env Health Ferapectlv* Vol 17, pp 1S9-192 1976 *In hto letter o! J Oct 19/8, Or Spin ah of JtOSH changed the ititui of Cnee 02 to VCH roductlon employee. Dr Splrtas also notified new Cite 01 ileo a VCH produt-tluu worker. Roee Rpnineki letter of 19 June I960 end tARC letter of I Apilt 1962 288600 s$fcf it it 'V ~'h ni Page 32 88620 SSU TABLE (Review Date - 1 Jan 1987) Incidence of ASL Cases Per Annum By date of death 1955 6 7 8 9 1960 1 2 ........................................................................................... .. .......... i......................................... ^............................... ............................................... ........................................... ........................................................................................... ........................................................................................... ............................................................................................. ... ................... ... ...................... 1 0 1 0 0 0 1 1 3 ............................................................................................................................................... 0 4 ............................................................................ 5 ........................................................................................... 0 6 ...............................................................................................0 7 ...................................................... rr.............................. 1 8 ................. 5 9 ........................................................................................... 3 1970 ............................................................................................ 2 1 ...................................................... r............................. .. 3 2 .................................. 5 3 .................................... 8 4 ........................................................................................... 5 5 ............................. 11 6 .............................................................................................11 7 ........................................................................................... 9 8 ........................... ...............................................................10 95 1980 ............................................................................................ 10 1 ........................................................................................... 5 2 ........................................................................................... 2 3 ............................................................................................ 10 4 ........................................................................................... 7 5 ........................................................................................... 5 6 .......................................................................... ..............___2 Total 125 2 .` I t Does no t i nc 1 ud e Italian 01 hut does 1 nc 1 ud e German 03 . 2 The 1977 total Inc ludes US- case 24 which is a Cholahglosarcoma, 3 The total does not include US 33 and 36, F 15 and G31 and 32 who are alive WPX/ASI.2 MNC[OCASI-:S,8 Page 33 Distribution of ASL Cases by Country TABLE 2 (Review Date - 1 Jan 1987) USA W Germany France UK Canada Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway 36 *** 31 A A AAA 2 1 AA A 12 10 5 **** 4 ***** 4* 2 2 2 1 Total 130 * Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholanglosarcoma; & US 33 and 36, F 15 and G 31 and 32, who are alive. **** Includes one monomer worker. ***** Includes two monomer workers. i.e Western Europe North America Rest of World 76 46 8 ^88600 S$y Total 130 t A 1` I O I AMOmCASKS.9 S8860 S'Sd Page 34 Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1987) (a) W Europe Of the 76 cases In U Europe, 65 have occurred in clusters at 11 factories. Of the 31 German cases, 28 have occurred in clusters at 4 factories. ASL Cases Dynamit, Troisdorf, Germany BP, Barry, UK Via eke r, Burghausen, Germany Chloe Chimie (Formerly RP), St Fons, France PCUK, Brignoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Germany ICl, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium 12 9 9 8 7 5 A 3 3 3 _2 65 NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 46 cases in M America, 38 have occurred at four factories out of a total of 54 factories:- In N America 42 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawlnlgan, Canada UCC, S Charleston Goodyear, Niagara {^ 10 10 4 jr 3j NB* There are 28 pre 1962 PVC plants in N America;.12 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 8 ASL cases are believed to be in 1 cluster of 4 and 2 clusters of 2 cases. WPX/ LANGIOCASES ,10 ' j ; i Page 35 TABLE 4A (Review Date - 1 Jan 1987) Latency Periods (Years from first Exposure to Diagnosis) Count ry No of Cases W Europe Belgium 2 France 21 Germany 31 Italy A Norway 1 Sweden 5 N America UK 12 76 US 36 Rest of World Canada Czechoslovakia 10 46 2 Japan 2 Luminary Yugoslavia W Europe 4 8 76 N America Rest of World 46 / 8 130 Total Years 35 545 632 74 22 122 272 1702 910 204 1114 30 39 85 154 1702 1114 154 2970 Average 17.5 25.95 * 20.38 * 18.5 22 24.5 22.66 * 22.39 W Europe Average 25.27 * 20.4 * 24.21 N America Average 15.0 19.5 21.2 19.2 Ret t of Worl* Average 22.39 24.21 19.2 22.84 World Average * Of the countries with > |0 cases, France, aid USA have an average latency period above world average, Germany, UK and Canada below world average. Ul>v/A<0? - [.ANGIOCASKS.lt * " 9886E0 SSU Page 36 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1987) Z886C0 SSU 11 1 1 1 11 11 1 1 1 I1 1 0-9 yrs 1 10-14 yrs | 15-19 yrs | 20-24 yrs \ 25-29 yrs | 30-34 yrs 1 35+ yrs | 11 1 1 l1 1 1 1 Belgium 1 11 1 Canada 1 11 | Czechoslovakia 1 t111 1 11 1 1 2I 1 11 I1 \ 3| I 5| 2I 11f 1 It 1f 1 1 11 11 11 1I 11 11 1 France 1 1 f 1| \ 4f 1 31 7| 31 1 3I | Germany i i \l 1 1 1 5| 9t 10* i 5| 21 1 1 l Italy ) Japan | Norway | Sweden 1 1 I1 1 11 1 |1 1 11 1 1 1 I \ 11 1 1 21 21 1t 1 111 1 I 1 1 1| L| 1t1 1 ! 1 1 1 1 11 11 11 1 i l 1 21 1 2I 1 1 1 1 1 1 |I 1 1 1 1 UK I1 1 t1 11 1 5| 11 1 4 t 2i 1 1 USA | Yugoslavia 1 1 1 1 1111 11 f 21 7| 9t 8t 51 5| | 1 11 1 11 1 1 11 41 t1 11 1 1 1 1t | TOTAL 11 I 11 1 12 1 1 33 1 1 35 1 28 1 1 13 1 1 8I i1 1 t tl !1 1 1 Average | Total t 1 Latency [ 1 1 Period 1 11 I1 2 II J1 10 1 1 17.5 | 20.4 1 11 2 1I 15.0 | 11 21 t 1 11 31 11 25.95 | 20.38 | I! 4 II 18.5 | l1 2 tt 1I 11 1 11 19.5 | 22 | I1 5 II 11 12 1 I 11 36 1 1 24.5 f 2: .66 | 25.27 | 11 4 11 21.2 | 11 11 130 I 1 22.84 | tt * Includes G 03 aerosol can filler WPX/ASL2 - LANGIOCASES,12 Page 37 (Review dace 1 January 1987) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE 1 YEAR OF l LATENCY PERIOD | ARITHMETIC :;ean 1 1 LATENCY PERIOD | FIRST EXPOSURE 1 (NO OF YEARS) 1 OF LATENCY PERIODS 1 [ 11 1 11 47 I 1939 1 38* 46 1 ' .1940 1 11 1 244 s 34.86 1 1 J 45 | 1 1 37,21,37,41 44 1 2 1 32,38 17 1 1 1 20 43 1 1 | 3 1 38,14,32 1 1 4 1 28,11,24,20,24,34,39 1 718 = 26.59 1 5 1 27,22,28,29 1 27 1 <n o CO | 6 1 21,29,31,26,28,15,23,1 1 1 30,35 1 1 CO 1 co Oo 39 1 7 1 29,24,29,28 1 1 CO 38 1 8 1 28,24,34 I 1 1 9 1 30,26,20 1 521 24.80 1 I 1950 1 26,22,31,19,23,14,33 I 21 1 | 1 1 19,28,17,28,34,29 I' 1 t s 34 1 2 1 21**,15 1 1 33 1 3 1 25,22,23,22,20,31,22.| 1 1 32*** 1 1 1 1 4 1 21,21,25,25,21,28***,! 1 | 1 22 1 . 787 IB 22.48 1 | 5 I 22,23,24,14,19,21,27 | 35 1 ! 1 27*** 24,28,30*** 1 1 1 6 1 21,12,27*** 1 I 29 1 7 1 19,17,15,13,16,28 I 1 28 1 1 8 9 1 18,18,15,17,20 1 16,21,25,27 11 `1 490 m 18.14 1 j I 1960 1 13,18,21,25,24 1 27 ! | 1 1 15,16,16,16,19,19,12 | 1 24 1 2 1 13.18,17,12.18,21 1 1 23 | 3 1 16,17,20,21 1 4 1 16,17 11 1 180 is 16.36 1 | 5 1 11,19 1 11 1 1 1 6 1 9,18 19 1 7 1 16 18 1 8 1 18 19 | 1970 1 13 | 1 11 14 1 13 -1 21 1j 1 41 | TOTAL 1 130 CASES 11 11 11 1 31 m 15.5 1 I2 1 1 1 VIOLA 1 1 1 11 1 1 1 MALT0NI 1 1 GOODRICH ! 1 297 1 *s 22.85 1 11 1 130 1 * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; F15 and G31 and G32 still alive. WPX/ASL2 - LANGIOCASES,13 R&S 039889 Page 3 (Review date 1 January 1987) TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAX POSSIBLE 1 YEAR OF | LATENCY PERIOD 1 FIRST EXPOSURE | LATENCY PERIODS IN WESTERN EUROPE 1 NORTH AMERICA 11 1 47 1 1939 1 1 38* 46 1 1940 1 1 45 1 1 1 37,41 1 21,37 44 1 21 1 32,38 43 1 3 I 38 1 14,32 1 4 1 28 1 11,24,20,24,34,39 1 5 1 27 I 22,28,29 1 6 | 21,29,31,33 1 26,28,15,23,30,35 39 1 38 1 1 7 1 29 8 | 28,34 9 1 30,26 1 24,29,28 1 24 1 20 1 1950 | 26,22,31 1 19 1 1 | 19,28,34,29, 1 17,28 34 1 2 1 21** 1 15 33 1 3 I 25,22,22,32*** 1 23,31 1 4 | 21,21,25,25 1 21,28*** 1 5 | 22,23,24,27***24, 28 14,19,21,27 1 | 30*** I 6 1 21,12 1 1 27*** 29 1 7 I 19,17,15.13,28 1 28 1 8 I 18,18 1 15 24 23 - 1 1 1 1 1 1 9 1960 1 2 3 4 | 16,21,25,27 | 13,18,21,25 | 15,16,16,16,19,19 I 13,18,17,18,21 1 16,17,21 l 16 I 1 24 1 12 1 12 1 20 1 17 1 5 1 11,19 1 1 6 1 9,18 1 19 1 7 1 16 1 18 1 8 1 18 1 1 9 1 13 1 1 VIOLA 1970 11 1 1 1 | 1 21 1 1 MALTONI 3 1 TOTAL CASES 1 1 76 1 1 46 1 * Qiolangiosarcoma ' ** Aerosol can filler *** US33 and 36; F15 and G31 and 32 still alive 1 ROW 1 I i 1 1 1 1 1 1 I 1 1 1 23,14 1 1 22,20 1 22 1 1 1 1 16 1 17,20 1 11 1 1 1 I I 1 1 I 1 1 | 1 1 18 WPX/ASL2 - LANGIOCASES,14 TABLE 4E Page 59 (Review dace 1 January 1987) PLANT 1 START | LATENCY PERIODS OF ASL CASES | NO OF 1 AVERAGE 1 UP | IN SPECIFIC PLANTS | CASES | LATENCY PERIOD 1 DATE I (10 OR MORE CASES) !I 11 11 LOUISVILLE 11 I | 1940? | 12,14,15,19,19,20,24,27,28,28,28,29,29 1 1 14 | 23.07 USA 1 1 31 11 11 1| TROISDORF 1 1954 1 12,13,16,16,18,19,19,21,23,25,28,29 1 12 | 19.91 W GERMANY 1 1 1 1 11 li SHAWINIGAN 1 1943 | 11,12,14,21,22,23,24,24,26,28 1 10 | 20.5 CANADA 1(1941?) 1 1 S CHARLESTON I 1939? | 24,30,32,32,34,35,37,38,38,39, 1I ii 1 10 1 33.99 USA 1 1 11 11 11 R&s 039890 WPX/ASL2 - LANGI0CASES.15 Page 40 (Review date 1 January 1987) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) YEAR OF FIRST | LOUISVILLE | TROISDORF | SHAWINIGAN EXPOSURE I USA I W GERMANY | CANADA 1939 1 1 1940 1 1 11 1 21 21 1 31 1 14 4 1 20 1 11,24 5 | 28,29,27 61 7 1 29,28 I 22 | 26,28 1 24 8 1 24 4, 91 1 1950 1 19 11 | 29 2 1 15 1 3 1 31 | 23 4 I 28 1 21,25 ! 5 1 14,19 | 23,28 1 6! 1 12 1 71 1 13 1 81 1 -.9 1 1 1960 1 11 2 1 12 | 16,16,19,19, 1 12 1 18 S CHARLESTON USA 38 37 32,38 32 24,34,39 30,35 ' R&S 039891 WPX/ASL2 - LANGIOCASES.16 Page Al (Review date 1 January 1987) TABLE 4G PLANT START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES AVERAGE PERIOD BARRY 1 1948 | 9,17,18,28,31,33,18,19,18 1 9 | 21.22 years UK 1 1 BURC'-iAU SEN | 1933 1 11 Ij I 17,21,22,25,24,13,21,32,30 1 9 | 22.77 W GERMANY | 1 ST FONS | 1939 1 t 21,28,29,37,38,27,41.34 11 l| 1 8 1 31.88 FRANCE BRIGNOUD FRANCE SUNDSVALL SWEDEN NIAGARA | ! 1 1 1 1 1 1 1 1950 1945 1947 1 | 11,16,18,26,30,25,34 1 1 | 16,19,27,29,31 1 | 15,17,21,23 11 1I 1 7 | 22.85 11 1| 5 1 24.4 11 1| 1 4 1 19 USA I 1 SPLIT I YUGOSLAVIA! 1 MARL I 1950 1948 1 1 | 20,20,22,23 I | 15,16,22,21 1I 1| 1 4 1 21.25 11 || 1 4 1 18.5 W GERMANY 30 Bo (/) o co (O 00 CO ro WPX'ASL2 - LANGIOCASES, 17 TABLE 4H Page 42 (Review dace 1 January 1987) R&S 039893 WPX/ASL2 - LANGIOCASES,18 Page 43 TABLE 5 (Review Date - 1 Jan 1987) Annual Incidence-of A?L Case! (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 l 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 1986 TOTAL 1 1 Western Europe 1 North America 1 11 |1 i t1 |1 |1 |1 1 15 |1 12 11 |1 11 12 14 |1 11 t4 13 1 2 16 14 16 13 16 13 |7 |5 12 | 16 t4 |5 10 |l |1 |7 13 |5 12 15 1 12 t | 73* ** | 44** Rest of World 1 3 1 2 1 - 8 Annual Total 1 1 1 1 2 1 5 3 2 3 5 8 5 11 11 9 10 5 10 5 2 10 7 5 2 125 | Cumulative | Total 1 t 11 1 21 1 31 1 41 16 17 I 12 1 15 1 1 1 1 1 17 1 I 20 1 1 25 1 33 I 38 t 49 I 60 1 69 1 79 | 84 | 94 1 99 1101 1111 1118 1123 | 125 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I Key Events 1 1 1 1 1 1 1 1 l | Viola 1 1 | Maltoni | Goodrich t 1 1 1 1 1 1 1 1 1 I 1 * Includes C03 aerosol can. filler but omits It 01 bag extruder ** Does not include US33, aiid 36, F15, G31 and 32. All still alive. WPX/ASL2 - LANG10CASES,19 ^68600 m R&S 039895 Page 44 TABLE 6 (Review date 1 January 1987) ASL CASE NUMBERS YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) I KEY 1 | EVENTS 1 1 I 1 1955 1 0 17 18 19 1 1960 11 12 13 14 15 16 17 18 19 I Viola 1 1970 11 1 |Maltoni 1 |Goodrich 1 2 3 4 1- 5 16 17 18 1 19 J 1 1980 11 12 13 14 I5 16 1 Total 1 | WESTERN EUROPE i | NORTH AMERICA 1 | 11 11 1 Cl I 1 i C2 1 I i1 it 1 i | US8 I 1 | C3 1 1 | US5 1 I 11 1I 1 FI 1 G1 1 Swl | G2 1 1 C4,C5,US4,US7,US10 I US12.US16 | US11 I C6.US2 1 1 1 1 1 I N1,Sw2,UKl,lt2 I G3** I G4,G5,UK3 | F2^3,G6,G7,G8,It3 1 C7 I C8.US1.US3.US23 I C9.US13 | US6,US9,US18,US26 1 I 1 I 1 Bl,F4,F5,F6,F7,Sw3 1 F8,F9,G10,Gll,G12,Sw4 1 Fi0,Fll,G9,Gl3,G15 | US19,US20,US22, | C10.US21.US24* | US27.US28 1 1 1 1 G16.G17 1 1 F12,F13,UK4,UK5,G18 ! 1 UK6, UK7,G19,Sw5,G20,G21US | US17, US29 1 1 US30.US32I 1 lt4,Fl4,UK8,G22,G23 1 1 G26 I US31 | UK09,It5,Fl7,B2,G24,G25,G30 | US35, US34, US38 | UK10, F16, F18, G27.G29 | US37.US39 1 1 1 1 I UK11, UK12,Fl9,F20,G28 I F21.UK13 1 73*** 1 1 I 44*** 1 I 1 1 REST OF WORLD! | j Cz2 Y1,Y2,Czl Japl Jap2,Y3 Y4 8 iL I 1 1 1 t I I I I 1 i I * Cholangiosarcoma ** Aerosol can filler *** Does not include US33 and 36, F15 and G31 and 32. All still alive. WPX/ASL2 - LANGIOCASES.20 Page i+5 (Review date 1 January 1987) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) 039896 KEY '1 1 1 EVENTS ! WESTERN EUROPE i 1 NORTH AMERICA 1 1 REST OF WORLD 1 i 1939 i 1 1 US24* I 1 40 i 1 IFrl1,Frl6 I 1 C3.US27 1 I 21 1 US13, US29 1 3 t Frl4 1 C2.US19 1 4 IUK1 1 Cl ,C5,US5 ,US7 .US28.US35 1 5 1 Sv2 1 C4,US3,US9 I 6 1Frl,Fr3,Sw4 1 C7,C9,US8,US11,US21,US311 7 1 Sw3 1 C6,US22,US26 ! 8 1Fr9, Frl7 1 US1 1 9 |Frl2,Fr4 1 US12 1 50 |Fr7,N1,UK8,UK9 1 US16 IY2, Cz2 1 1awj UK5,Fr20,G30 1 US10, US32- 1 2 I G3** 1 US4 | 3 |G15,It3,G26,G31*** 1 CIO, US37 IJapl.Yl 4 |G7,G8,UK4,G19 1 US18.US33*** 5 |G11,G16,G18, Frl5*** 1 US2,US17,US20,US34 IY3 1 1G23,G28,G32*** 1 1 6 |FRIO,G1 7 |Fr8,G4,It2,G2,UK12 1 US36*** 1 | iCzl 8 |Fr6 ,B1 1 US23 |Jap2,Y4 9 | Fr2,It4,Fr l9,Fr21 1' 1 60 |G5,G13,G25,G28 1 US39 1 1 HG9,G10,G12,G17,G20 ,G221 C8 I ' 2* \Cf ,TTK6 ,G21 ,B2 ,G29 3 IFrij, UK7,Frl8 1 US6 1 US38 1 1 4 | Swc 1 US30 1 5 1Fr5,UK11 1 1 6 | UK"*, UK10 1 1 7- 11*"5 1 1 8 IUK13 1 1 9 I G24 1 Viola 70 1 1 1 1 1 11 1 1 112 1 1 1 Maltoni 31 1 1 1 Total 1 7 6 1 1 46 1 18 11 * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** US33 and 36. Frl5 and G31 and 32 are still alive. WPX/ASL2 - LANGI0CAJTS.21 Page 40 "KVAbLC - ^.^U^AOr.5,^ (Review date 1 January 19S7) TABLE 8 WESTERN EUROPE FVC PRODUCERS - START-UP DATES vs ASL CASES (CMITTING C03 & It.Ql) R&S 039897 START-UP | COUNTRY NAME I COMPANY NAJ i lcgaticn ( ASL CASE MM3ER | YEAR OF -- YEAR 1 1931 |LL_t Gernsny IBASF 1 1 Ludwigshaf en I 1 | 1st Exposure 1 1 1933 IWest Germany Ifecker IBuighausen 104,07,11,15,23,24157,54,55,53,55,69,60 1938 1939 1940 1945 1 1 (25,31,32 1 Italy (France IMontecatini |Acna IFhone Poulenc/ (St Fons 1 103,09,10,11,14 ! 1Atochsn 1 1'5,Vi, 17 I United Kingdom! ICI 1 Runcorn 1 Kingdom | IQ IttLllhouse 101,04,12 I Sweden IKaaanord |Sundsvall(Stockvik) 101,02,03,04,05 | Switzerland |Lonza/IQ slncelSins 1 ( 55 1 146,48,56,41,43, ( 55,41,48 . 1 144,54,57 151,45,47,46,64 1 1 1 1 1 1 1 1 1 1 1946 IFraixre 11982 1 IRhone-Poulenc IRousillon 1 (01 1 146 1 1 1947 1948 1949 1950 (Italy (Montedison (United KirgdanlBP (han/IQ 1 |since 1982 IWest Germany ICWl/Huls (Belgian (Solvay I France IPCUK/Atochan IRrrto Marghera IBarry 1 Itferl (Jeneppe (Brignoud 102 157 103,05,06,07,08,09166,51,62,63,50,50 110,11,13 166,65,68 109,10,26,29 161,61,53,62 (01,02 158,62 102,04,05,06,12,19159,49,65,58,49,59,51 1 1 1 1 1 | 1 | France |Holland 1 IRhone-Poulenc I St Auban iShell ' Demis 120 107 i I |50 1 1 I 1 |Norway 1951 I Italy (Norsk | Montedison IHeruya I Brindisi 101 1 150 1 1 1 1952 I Italy |Monedis<xi ITemi 1 1 1 1953 |Austria IHalvic IHallein r 1 1 (France (Solvay ITavaux 108,13,18 157,63,63 1 lltal.v (Solvay I Ferrara 103 153 1 |Spain - |Rio Rodano |United Kingdom |BIP 1 Bernard. | Aycllffe 1 '1 1 .1 A w IWest Germany IHoechst IGendorf 118 (55 1 1954 I West Getnany IDynanit ITroisdorf 101,02,08;12,16,17|56,57,54,61,55,61, 1 1 1955 1 Spain 1 | Monsanto IberiaIMonzon 119,20,21,22,27,30(54,61,62,61,55,51 11 1 I 1956 | Spain ICaiqsa ISabinanigo 1 1 1 1 (Hispavic 1958 latest Germany ISolvay (Torrelavega (Hreinberg 1 1 1 1 1 1 I960 IItaly |S C Ravenna I Ravenna 104 159 1 |West Germany |Lanza/IQ since |Waldstiit 106,13,28 162,60,60 1 1 11982 1 11 1 1962 (Portugal 1965 I France (Clres I Oporto | Rxne-Poulenc IMontlucon 1 121 1 |59 I 1 I Italy IPozzi IFerrandina 1 1 1 |West Germany IVfecker I Cologne i 1 1 1966 IWest Germany IHoechst I Knapsack( Frankfurt) 105* |60 t - 1 1967 1 France I Spain |AID Chimie |Rio Rodano |Balan |Miranda de Ebro 1 1 1 1 1 | Greece |Esso Pappas IDiavata Salonika 1 1 1 1968 I Belgian IBadiphil I Antwerp 1 1 1 1969 | United Kingdom !Vinatex IStaveley 1 1 1 (Italy IRunlanca |Cagliari Sardina 1 I 1 1970 I Italy ISIR I Porto Torres Sar 1 1 1 1 United Kingdom I IQ I Runcorn 1 1 1 1971 J Italy |S C Ravenna |Ravenna 1 1 1 1 Spain |Sweden |Hispavic IKenanord IMartorell iStenungsund I 1 1 1 1 J| |United Kingdom IBP them 1972 I Filled IPekana IBaglan Bay |Svartbock 1 1 1 1 i 1976 1977 (Holland 1 France 1 Spain IDSM IBeek Limburg |Soc Art D'vinyl |Mazlngarbe | Monsanto Iberia I Tarragona 1 1 1 1 1 1 i i i * Laboratory worker In Research Department '' f ^f j, - .. - -- m*,--- J-* fc-#- , +m~\ J ^ f-V-\ 43 P1 TABLE 9 Page 47 (Review date 1 January 1987) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP I COMPANY NAME I LOCATION 1 ASL CASE | YEAR OF | YEAR I 1 | NUMBER I 1st EXPOSURE I 1939? |*UCC 1 S Charleston 107,13,19,21,24,144,42,43,46,39, I 1 127,28,29,31,35 141,44,42,46,44 | 1940? | *BFG 1 Louisville 101,02,03,04,05,148,55,45,52,44, | 1 106,09,16,17,22,162,45,50,55,47, | 1 126,33,34,37 147,54,55,53 I 1946? |*UCC 1 Texas City (Partially closed 1977)| | 1947 | Goodyear 1 Niagara Falls 108,10,11,20 146,51,46,55 | 1948 | Firestone/ 1 Pottstown 112 149 I | Occidental 1 11 1 I Uniroyal 1 Painesville I I 1 1 (closed 1975) 1 1 1 1950 | Monsanto I Springfield 132 |51 1 1 (Closed 1975 1 1 1 1952 I Dow 1 Midland (No PVC since c 1975) I I .( BFG 1 Avon Lake 118 154` 1 1953 1 BFG Deer Park (Formerly Diamond) | | 1954 | Genr -al Tire 1 Ashtabula 136 156 I I(Closed 1984) 1 1 1 1956 I Air Products 1 Pensacola 1 1 1 | Atlantic Refining 1 Brooklyn(Closed late 1960s) I I | Borden 1 Leominster (Closed 1984) | I 1 Conoco 1 Hebronville (Closed 1975) 1 I 1 BFG 1 Niagara 1 1 1 | Great American 1 Fitchburg 123 158 I | Plastics 1 (Closed 1983) 1 1 1 1 Hooker 1 Hicksville (Closed 1980-81) | | | Pantasote I Passaic(Closed 1984) 39 |60 1 1957 | Atlantic Tubing | Tenneco 1 Cranston (Closed 1967) t ^lemirston NJ |30 I 159 I I 1 (Closed 1985) 1 1 1 1958 | Keysor Century 1 Saugus, Cal 1 t 1 1960 | BFG 1 Watson, Cal 1 1 1 | Air Products Calvert City 138 |63 1 ! (closed March 1982 Re-opened October 1983) I | Borden 1 Illiopolis 1 1 1 1962 | Tenneco/Occidental 1 Burlington NJ 1 1 1 1963 | Conoco/Vista 1 Aberdeen, Miss 1 1 1 | Stauffer': 1 Long Beach, Cal (Closed 1982) I 1 1965 | Conoco ** 1 Assonet, Mass (Closed by Olin 1975, see below) | Ethyl 1 Baton Rouge (Closed 1984) |! 1966 I Georgia Gulf 1 Delaware City (Formerly Diamond) I |Gen Tire/Pantasote 1 Mt Pleasant W Va |(Closed 1982) I I BFG 1 Henry, 111 11 | Stauffer Delaware City (Sold to Formosa 1983) 1 .1967 . | Allied *** 1 Painesville, 0 11 1 (sold to Robintech) 1 1 | Hooker/Occideutal 1 Burlington NJ 11 1968 | Firestone 1 Perryville (Closed 1982) 1 1 1969 I BFG 1 Pedrickton NJ 11 | Goodyear 1 Plaquemine 11 | Olin ** 1 Assonet, Mass (Closed 1975) (See above) I | (Formerly Conoco) 1 11 1971 | Conoco/VIsta 1 Oklahoma City 11 R&s 039898 WPX/ASL2 - LANGIOCASES,23 Continue d Page 48 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES ISTARf-UP I I YEAR 1 1 1972 | 1 1973 | | 1 1 1 1 1 1974 | | I 1 1975 | | | I 1979 | | 1 1983 | COMPANY NAME I Nat Starch Borden Robintech *** ! | | | 1 1 1 1 Atlantic Tubing/ | Tallyrand | Shintech 1 Certain-teed | Georgia Pacific | Tenneco/Occidentall Firestone/ Occidental Formosa | | i LOCATION | Meredosia. 111 Springfield Painesville, 0 1 | ; | (sold to Georgia | Pacific who 1 converted to | polystyrene) I Cranston RI (Closed Freeport, Tex Lake Charles Plaquemine, La Pasadena, Tex 1 | I | | Plaquemine 1 1 Point Comfort, Tex| ASL CASE NUMBER 1982) 1 YEAR OF | 1 1st EXPOSURE | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 * My databank has no information on UCC before 1946 or BFG before 1950 ** Refers to same plant at Assonet ***Rt_.Jjr to same plant at Painesville. Allied plant never operated again for PVC after it was sold to Robintech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. 37 So CO I 66eeeo WPX/ASL2 - LANGIOCASES.24 Page 49 (Review date 1 January 1987) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1943 (1941?) 1951 1957 1966 1979 COMPANY NAME Goodrich Monsanto Goodrich Esso Diamond Shamrock Alb 1 TCCATION | ASL CASE | YEAk OF 1 I NUMBER I 1st EXPOSURE 1 1 Shawlnigan 11 101,02,03,04,05 144,43,41,45,44, 1 106,07,08,09,10 147,46,61,46,53 1 11 1 11 1 La Salle (Closed 1975) 1 1 11 1 11 1 Welland 1 1 1 11 1 1 Sarnia 1 1 1 11 1 11 1 Fort Saskatchewan 1 1 ! 11 1 WPX/ASL2 - LANGIOCASES,25 30 &> CO O GO CO CD O O Page 50 (Review date 1 January 1987) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES I START-UP! COUNTRY NAME YEAR 1 Pre 1939|East Germany 1941 |Russia | COMPANY NAME 1 |State Company |State Comps 1950 1951 1955 1956 1957 I Yugoslavia (Jugo Vinil I Czechoslovakia |State Comps lEast Germany I State Comps 1 Rumania |State Comps 1 Poland |State Comps |Rumania (State Comps 1958 1959 1 |Rumania I Hungary 1 [State Comps |State Comps 1961 1963 1965 1967 1969 1970 1972 1975 1976 1977 |Rumania 1 State Comps I Yugoslavia ! Ohis 1 Bulgaria |State Comps I Poland (State Comps I Russia I State Comps |Rumania I State Comps 1 Russia |State Comps I Yugoslavia IVinilplastika |Czechoslovakia!State Comps I Russia I State Comps I Yugoslavia 1 Hip |Rumania |State Comps 1 LOCATION 1 ISchopau I Vladimir et al (Split INovaky |Bitterfeldt IIcechim IOsweicim (Dwory) |Tirnaveni ITurda IRisnov IBerente Borsod |Borzesti ISkopj e I Varna |Tarnow I Dierjinsk |Rimnicu Vilcea |Volgograd I Zadar |Neratovice IKalush Area IPancevo |Rimnicu Vilcea | ASL CASE | NUMBER 1 1 101,02,03,04 101,02 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 YEAR OF 1 1st Exposure 1 1 153,50,54,48 157,50 1 1 1 I ! 1 1 i 1 1 1 1 1 1 i R&S 039901 WPX/ASL2 - LANGIOCASES,26 R&s 039902 Page 51 (Review date 1 January 1987) TABLE 12 JAPANESE PVC PRODUCERS - STAPr-LT SATES vs ASL CASES START-' T1 COMPANY NAME YEAR 1 1950 1 Chisso Corp 1 Kanegafuchi Kag 1 Tekkosha 1951 1 Mitsui Toatsu 1952 1 Mitsubishi Mon 1 Sumitomo Kag 1951 1 Denki Kagaku 1 Nippon Zeon 1 Toa Gosei 1955 1 Ryo-Nichi 1956 1 Nippon Zeon 1 Nisshin Kagaku 1957 1 Kureha Kasei 1 Shinetsu Kag 1960 1 Denki Kagaku 1964 1966 1 Kanegafuchi Kag 1 Chisso Corp 1 Tokuyama Seksui 1967 1 San Arrow Kagak 1 Sumitomo Kag 1968 1 Ryo-Nichi 1 Shinetsu Kag 1970 1 Chisso Corp 1 Denki Kagaku 1 Kanegafuchi Kag 1 Kawasaki Yuki 1 Mitsui Toatsu 1 Nissan Kagaku 1 Shinetsu Kag 1971 1 Tekkosha 1973 1 Asahi Glass 1974 1 Toyo Soda 1975 1977 1 Central Kagaku 1 Toyo Soda 1 Unknown 1 LOCATION 1 | Minamata | Osaka I Sakata | Nagoya | Yokkaichi 1 Kikumoto | Shibukawa 1 Kambara | Tckushiir' I Uozu I Takoaka 1 '"akeo | Nishiki | Naoetsu | Ohmi I Takasago | Chiba I Tokuyama | Tokuyama ' | Chiba | Mizushima | Tokuyama | Mizushima | Goi (Chiba) ) Kashima | Kawasaki | Sakai | Chiba I Kashima | Yokkaichi I Hayatsuki I Sakata 1 Yokkaishi | Kawasaki | Yokkaichi | Kashima | ASL CASE I NUMBER 1 1 1 01, 02 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ! 1 1 | YEAR OF | 1st EXPOSURE 1 1 1 1 53, 58 | 1 1 1 1 1 f 1 I 1 ! 1 1 1 1 1 1 i 1 1 1 1 1 1 1 1 1 4 039903 Page 52 (Review dace 1 January 1987) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UPI COMPANY NAME YEAR 1 1953 I Monsanto Mexica 1954 I Policyd 1955 | Geon Do Brazil 1956 I Elchlor 1960 | Electrochlor | Viplastic 1961 I Indupa 1965 |(5QC Paramanga 1(1967 start up I PET Coluraviana 1966 | Carburo De Col 1967 | Plasticos Omega 1968 I : -imex 1970 I Policasa | Petro Dow 1971 | Polimeros Mex 1975 | Rico Chemicals 1976 | Petroplas 1977 | Indust Reslstoc 1978 | Huls Brasil I Polychem 1 Policyd 1979 | PET Camacari | LOCATION I 11 | Lecheria (Mexico) 1 I Mexico City (Mexico) 1 I Sao Paulo (Brazil) 1 | Sao Caetano (Brazil) 1 ICapitan Bermudez(Argentina) 1 | Mendoz (Argentina) 1 | Cinco Saltos (Argentina) 1 I Paramonga (Peru) 1 )1 | Cartagena (Colombia) 1 | Medellin (Colombia) 1 | Mexico 1 | Puebla (Mexico) 1 | Managua (Nicaragua) 1 | Conception (Chile) 1 I St Martin Puebla (Mexico) t | Guyanilla (Puerto Rico) 1 1 EL Tablazo (Venezuela) 1 | Tlazcala (Mexico) 1 | Cubato (Brazil) 1 | El Salvador 1 | Coatzacoalcos (Mexico) 1 I Camacari Bahia (Brazil) 1 ASL CASE NUMBER 1 YEAR OF I 1st EXPOSURE 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 I 1 1 1 I 1 1 1 WPX/ASL2 - LANGIOCASES,28 Page 53 (Review date 1 January 1987) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES I START-UP |COMPANY NAME | YEAR 1 1 1 Mid 1950s I ICI Australia 1 I 1960s | B F Goodrich i (Late 1970s | ICI Australia 1 1 | LOCATION | 11 11 | Botany, Sydney I i1 i 1 | Melbourne i l | Laverton i | | Melboui..<- | 11 ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE 1 1 | I I 1 1 1 R&S 039904 WPX/ASL2 - LANGIOCASES,29 Page 54 (Review date 1 January 1987) TABLE 15 MIDDLE EASTERN PVC. PRODUCERS START-UP DATES START-UP 1 COUNTRY NAME- DATE 1 1 Sept 1986 1 Saudi Arabia 1 1 1 1 COMPANY NAME 1 I1 LOCATION 11 | National Plastic I Arabian Petrochemical Company | Company IMadiant | (Ibn Hayan) IAl-Jubail 1 |Al-Sinahyah I R&S 039905 WPX/ASL2 - LANGIOuASE S,30 Count r ICI CHEMICALS t POLYMERS CROUP LIVER Angloaarcoua Casea - (Review Date: l Jan |9..) COUNTRY AND REFERENCE NQ NAME OR INITIALS DATE Of BIRTH COMPANY 10 II 12 11 K IS FACTORY FIRST VC EXPOSURE OATS OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OF DEATH HISTO LOGICAL CONFIRMATI ON ESTIMATED EXPOSURE OCCUPATION LEVEL OTHER CAREER .ICHLICI1TS VPK/ASl, - LANUIOCAStS, |i OTHER COMMENTS 9066o s*y