Document qkpanOpK3edY80pjZ2YLO53jk

AR 336 -- 3237 | i 419 | | 09208aD5e1y6GGevaSavgueebeSStuodynciiTnnRRoattiviitthhOOnne:GGeeneerioonnRReepprreotdioonn vBaruaiionnss `TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats `with One-Generation Reproduction Evaluations Revision No. 1 Volume 4 of 5 AR2ReRvis6ed_Pag3e 237 DDuurpoon:s5t3s6 TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) AUTHOR: Gregory S. Ladics, Ph.D., D.A.B.T. ORIGINAL COMPLETED ON: December 3, 2001 REVISION NO. 1 COMPLETED ON: April 5, 2002 PERFORMING LABORATORY: E.L du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Nuvmz:[YD sevice Cone Novnex:{BY ronsonron Nowe: IIIS| - CompanySantized. ossrtcanTtSCiACnBI TT eee T ------------ ~ 8 3 3 = 8 ii i Y i 3Pol : :E go ifg of to Hal IEoo Bfaiittee, SgPoihw gdigliE aEe: 7icf .: g i 8 odiaEE e ggeRh REegp Egdidsi 1HI8T 1 gia oHgVpE NFi L1T: sil Hg bps EEE fed BgiE fiiTiSn-aat ifaddeeaslk 8 CC3fafa 2I OF dSpIilRgIiEEdItEEETr - ELEEGERazREs. BegEaiiier EpEaEin8 1.23f fy 8: Fleiss p gRUA0REEdE | Epes i i: i fs iEs: 1H 3 2 Tod 3 FzI is3 ggiiyif 8i :i 22 gifid -- 28 81513 -~ %g 88 : g 8 Eg d . a EFE o Cg o i ol: is . 4g.ai4t7 siis shodsty! Graft 1d 13 1FE :108 33 no _ 33 8 iogii fd fsBiifidiiggngdseay BEE 8 F EJgEReRfEtRgEeEC 2 gg ER gRRarant 2 FFEaLlL f igoefm Hohl. dh las 550 0 Fi21220% 5 By8 RNEGREEE | -EpPEpEEc : 511d i 81813 3 . 8 -2 3 i i po 3. 3 P ei op Hi0a8y4 i5o]e ~ gfsdgi HEfaEiLt Ll [i I 08 ngiDa gGg mia na B5 odaigg $8 GHD EL PHIESS ef gi SEEITS. g BRId ERE fDdodEiirSen aREnE Bpidxo ad 12 fie 3 Ph fheaias E43 5 faaige! 35 sli id FI --2 81313 z 3 . 8 : i 3 i AEE2 bo TN. 158 8 5 HE}.FEE ~ i Eo EgDEOBEiRRsElReL BRii fk P3 8ie1idl0ly offs d& iaiyf ridfEe 8 dfgpuiREiEnC nRyEF5 SE BGgguRlRE 51813 DEan ZaCEabzal g% NTT] Phaes lh inn EE al fff oaRla frel gfBREMEN EH itHEE1 8=| Bi1g8i1E3 B28BELD BSLE.EEMuEEREEE CC Egls k . cig ER SHEBwBe -- zg 8i18:3 3 3 5 8 : i i i a gd & 0 iB gens F LEREGTERE " 11 sg dhe 3 z T1813 PEGE 0 BRILL PoBBEuEES Sg&PopBBialicdfhiiyt Hs SRE d fof filE gRidcar igz HSFiI seZREGE {5 E(REEE GSUSSGSRESH ~~ pid . 8 Cy Poi Sil d8 oa fp dghEEy Ei SE yg he i Eo a REREEE 1 HEfiIl 2 E P15E1 EBoBEE 3L f57b Ea"RLEs 3E8gEaE gI48 BE gig BY 3gSE.iiel LE g8 EF oBiclniikel dSd fiwdgousgt b.o%f4 5 Bila p GEER MRSS cEsH MPE E 3 29 I5 s8 8EZ8 & |i } : E 3 4 3> _ : 3 2 i , :8 8 i g CL i 8 [I 5.820 on sEugiE gEE n Ets CEpdd og adn | Ff 1 : 8, iE Eughhhahm f EhRiEnD PEL Boz BiEiE 8 Gf i SET Blin GElogEgcED L.8% HELh Bl Taio als RAE GEZEEfGeEG. Seige pind --2 gi3i3 ig g i:5 3 i LE iEoo fsisafet,s iHkiEin 18 ig foomdatE Bl 0 i333 aie 10 Ef IE ia BE gE Eade BED io HE : i d 3 i1r 1 Hfl himhsefeEeaitatbyho E 73 EBigg Es SfEsadnEst Hi i[fLI 8 _3 8 3 i fo Hi PE ahi Co hm To ide ~ ls 4 Ege I: : 11 if all HE 3138 giaEr, pghglieaer sEpdl 3z i813 SuSBak a Ex LPPEoEiiIE dnd Uh hl 3 FRILiIEIN ELEotEraI HLge -- zg Rigid H8 - z2 :8 8g gE i3 Pio EEE ep EidPd 5" an 33 aPgoliPol FB fEaEtfe J8c 8 iHI HSEEERZ"SE ! oD g HI aHa E] Fifi . 1| 2 0a 08 Bigii BBoEE f-EBpZREEigTiEgEeRs" xEiN & i 08 ,iEailogppi dGiggufRaRiECsEEE go5n3 dF ES1E81 ogyf dpffaapgEEpsaedard 5FE88 2IFi Cif Glaifa88 d5B e.OEEBadErAS C8 o8 $ &2 i%is,n S $ifi ideRls . ifIdungdissgiee%sBigggeisetr | gEgiz3 3% 3 52% HPiEgiEELgESs F, EEELEEBELRELAR - OF BE yop : 2 alu 8 2 _iizs HHEEHE] 3 3 --- 8 2 3 8 I g& PHoI a HI SS=E ak BESy B Po ia 5 i 4B gee Po it Srgb i BonenHe . :: gf 0 uhasn 14 :83 q piiafl kBrFf BSmEEmPgEEkECReEEEShE. C2o0 dBoEg EGifli,igf.8 FPERgeERsTas.t fg d73 DE ohn dues 4% $ gt i gid. gEaicigs i 2i8i3fy | gee Biles i FFiiEiiiEiOERaE jSEEEgRRBEeSent paofs i8f HE ie LE iy $iyi i i _ 94 Bgiiadiief < = 23 8&8 8 - :3 5i3 3 8 i2 i { bo s I1 fila TEf 1hm ddehlaat 3388 iE Ehopor 3fhg3REgbEeiiaEye fi88 fEiIEaNp TiIb Ji Biel S| F hoaL dEd lint bgoo 5 Elie least CH BO is iid 8 ~ 4 5 i ohtadBR 3f5g IoED bgE giiPRe ptmeEp id 0 13 Gla dp EEE pp EII EA Lilt Hif 8 Biddy Bet SES ER 3 Lid ie Foggy g i3 = .' IREEEEE - JF EERE 5 BEE : 11 of fee digi Bp fin agit alt Gli 1g Ftliinn f Bgpihrf e Eh iFais,t 5 8iEiT 3 3 s ~3 g Po i 3 8 2 i3 3 g Lo EHI 3iS5diis l40%p Po gil - ls i Ea 1 2EI 8, PEeNi Lr5. Bopha gz8 "HBEELELETh iS = 18 ga ion ME 13 BEE 98 GEE Dr 51 8 mfieh Ln ff i fIFF Bgehiird o8f0 HGEiEs eiGmnimadasl gil $3 $BiIEiEE . BgFE Ba mRmR7 - h BEdEecBRs Ees 330. 3: Figg FEE Hi i iH FL 82 uaF LE oe it 18 3 22 2Ze3 ggiiyis 3 , f i 5 54 rt TE 238 3 2 i i g i i iPo o HLEN i g Ei G HgElag,ida ~ ly i Co, bJomppga of : ida8 Fil 33 aif gb1 BBDF FEE P BoRgimeae sit Het f Hi oS gw hE 8g mSiptily BEGREEngshr LREoEOhCrAE:E oy i Teg sg Ealing | B $5 =i ff if fig i 138 --~ iz giF:i8 i i z Eo Eo epddeis CFo o aiahe ~ (lsfp AdEEE oe 811088 l, falyy HBmeeEmEmLLEe oOnLof 2 i 35s fiiln BgistsHFs pgHOilHaE 3 SE GSapnEi ls sys sEEREE H23 ooStHEEN LEE ELH EI UET h : EEE : ; Es HE i: - ls og LEE IT f: ! i: Aiii 3 .Bg fk Lo EEE lg i, 368 ED pglgee I 0 Bpliaipn EGeeEt TSEEERIgiEnLe fHg L0aHds 5 [ERY 2% HEE pied RHEE siEE = is 3 = Ig LEE RE z z 88 ~x i z 2 Eo siioi iq 0 Bd z5 2 3i F g2 . H8i%s Ete Fi Sle&: I 13882 i E18H 18 aif U3 25 idiif 38 GEE 2x3 #z88 EE 3"B8 8544 HiSEs d25.e8 EER Ps$fig3o afd d 5 iE od FESR se SR BEE 8 Li 8FoghaPEtE?R 5 60H agyi BnoBRg E8 ET. BREE DE oDnloEe gpa dnd 3:$ gFSiii%lSliisyE fd4iaonzIatBreE 8Efg RcEiOEF 4[f3yL00fC12s4,IeF . ifgEEeRiFESsHy 5 [FIO BREESE 5 Raed FEAR p EINSRT Boos dF REE pry i: iio: Ho gigi f : B EH 2113 2 g 8 ~ :3: i ii2 [P iI o d i eh td 1 i seid co Pod hjEd Hgi ie; J&L SE i fi 8 1HI 1 08, Bdama dp iE ge oa)ir $874 BFI ohFL gf BR IE doF: EBdT idfdf dmheeEmt ES EE HEH gBgolg:s dyBonIfeaRdEE. PIiE ogoi naHnE RRDoonrn dLeii :i 5 $SfEilTe SES BfIiEtR POf oEo mpEEesipe diges | G.23F Ba eRiY ghi8t5g0d% figiga: F5H FTidai8b5sgEEdE F| e-Eolles O38EHEEHE p5 BEREEIE ios it EEE bg 33i0 HjslEyilLE8 i: 8] gig: i1: i:: : : - f : 5 3 2 i2 ] Eo ;2i co Pgoii Po f4:2l gE 4 Bla bs EcEoEg 43d Z [Sif gemS. lop HEL f50i Ediiiggsiiiye d3gg8EE3s0s pigis EE.: 0 EaladEds gfe Poc10EFf Ef CEHEREMl OSNSEEE : - 3438gE0a80 EH 2iFi3 -3 8 1: & g 2 g Fo s i i gsly a8 gi gE 888 Tt2 Pi om RaiERaEteTs TGsS 8 PE ogi hE fo 1189 8gi0ao6pp dmgin nby gbiu Bg go dpeft Eilifnel gm Betfedesss og CEE ieiEpE GE BEECHER 5 48 i Tai pnd FE 8 z i 3 g i 3 Sl hg i ii 5 dLIeETRRTEI d|SL!RbeidTdR 0 4 1PB0Ei4ala eBp omEgiiEeEEEny 10or0g 0 EISLI 1 I LF 5: BBiEhERk DRBEEoEaREmElE 1k RE yB o O ie ji it 8 - :3 | I4 8] 2 g [I Lapse is.2 LIE LH oF gin Ip dagfEREa 11 [heh Blum, gIi2 f3oillaiaiikned HpEin824e58t08 | ffi god LH pTOZiaEE ic2hgnSaTgEttGts oi je 2 id E pie: gz 3 2g iEi3 3 ~3 : 4 3 & i3 Pb it lL 0 is 80 fa. Ea 585g 8 iioli HooE giifegis Bob gs gEEhied th a EB REE : 11 23 db fpr Prop mele REEL 3 8118 z 3 8 - Z 3 z 5 23 i , 1 i i 0Pd 3. P iiod: idiis5s gf 5 Igiii LE1 Hfaisiilela 1 = FO igi itH . giEg.fRiEaEpEeL 1: LI i d38g i50E, uER ghBD eignRgEpeRecEad C4d 03 gail fF 5p igh ff 3Bi%ol fi0iE BpD eBD GmithEatiEslE B4C dge5 fibgii $ 8 gEza3s45t difiodaagiegdisds Ed 48.0 ith o[g 0osd Ey dBFiie BEE EB Sui. lmnhy cog BREE LE88 1 BH 2 E43 5 JRERRREEGE 5 2 45 al 3 Hi ER is [IEP -- 54 gifi3 3 EH 8igiT 3 2g 3 3 , Po ii g Po 20 i itl 35885 at siaaiis i 3 &i $ ue HEad ii 13fe 113,; i zig gWhEEdE nCo oLehdl: raflagel g9 zg8E.8 PE ai nul nn BfFF TI2 fRiidfitE 2Bi0a8l5z p.ofBg gAecTEU3EEESESE Ep.B0E%F0 Sff8alnBER P8Y fEg dlEaS0cneBniLieE hetSs 2h iE3o87 | g.e.s.%238 8 3 - 2 I 8 i i ; i LI ioi h0g irHils C8 id SE OE # ad HI iE Eu sgh oBgEEE 3I8f isnad; oHaegiE in GE op ED age ated g iki i 8 i 8gf EREESS Bee 3 dh gH Ek 3 HL : Liizl tMEhRiE isfs Esilyil s3 ~ ig iis Tz E g 3` 4 32 Z: ;g 3 3 i : i i _ : i3 & : fo i i eo i a lr mo gu gf gizis fe EB dRgEalig TE ogb [INH L IER fo E Ee Boole Fifi gBE.S off JE.EEE2 =8] 8&1 : 83 -~ 3 : i i 3 3g HE Po g Bis g i 4 giaz sih ii Co Basia gi iz 5.230508 Sgro Hoda DBoa 33088 gg (loan Bp HE SEFB 3&3 T d2o EH ~ 23] ffoae pFiail fdip fifi H0o gmitEaL%E gR5D 5pEo RRiEfRe cf dernE EE ai0, dBiiaRGl E dats sieiemsEen ht HE.ES CIHIAH LEHGE} REGEa ABEE SELLE BLLEL oi dE ci Bnd HEE 1313 f, lggaHUtoR HfEBASsELEdEHegEOiLRiELEal.I : : iv dy H5d8 Eb SEHgfi8L s3td EgE%H3 f i zg _ g 2 3 El ER Po A Po 1 ahd Pigalle lid gE %iLig i Bf 59 4 AEGgEa Fahd foe iast z 81813 2 ~ 3gi 831 ii | Eo @ vo BeLE gs 8 - lEs ooi, B seip zes 4 2 PR wf -BgEgEgy EE 18 sp Dodgy P3i8 cTieREnD pGeleafElelr 5 #iTi%lsk Beofuigdan Lid f{f eadE TE ha ff DEH Sel, BEE BoE : 1 IT 23 8i%ie ~3 a5 : : iii 0 : 8 & bo ZEEE. 4% E ii amkldgie,s _E J gp EJifafiegEEEs 4217 . 3 Eiozr gRfiBR fg 11 ist aE 18 sik del Z| 2 Bgiiag: lBuL 4B2g2lRBEaEbEEeLnES JE Citi dimes gif il E2 iZa CC 4g ffBoniDnIEgH RLHoOt,e a1E0k sd : -# 13  i8 -3 38 fd 2 8 z 3 2 ii Efii gLelsRaE ' i hEEid Ei, hha TE Bone i dass | diginE, fon IEEE Bn agtEabnelp BD Bl BE "leiEpdh a58gEab 8 fx 3 opliage Polit gown BIEIEEEE . fEgRaiiise | of (REE Fi ai FEAR p NRARRERGE ad HE iisk HfnE!E sa gi dian pala 2 8588 PRE EERE, FELELERS 8 ~3 z : : $ : I 1 &8 [oI l 02 % . BsoEk Sy oH i 52Eo PPoo 2mgE.H8, fl HEEES a _ P[oI Sgiuaga 4i 288%:: 52 . AIEEEI 3 fh : 15 08 P=E , mEgau . .13 0g oBuElEAdTM 11B38g sfBinhDif oBdmeEir pffireab oiBfr oanhiiflED EC0E8EIiLii+Iidf ASgghEeOEdRl Bg2 LE CoElESBHPELECDR VFI fEEzr8p%i8d% 3g f$PiI13O8ii1zE oc BBEeBRgRSEE.EC GH8a:Ed B8Bg5C ZgE3fn8gRft7 |RfBEgEEaEEaSenZRNd:Yt ct] 1ii8 SRRSE 5 Red IE ROHR p SENS 35 =i Ff EEE Of PE EX Ri5:3 3 3: 8 --_ 2 3 i <` iE i & Pi aP OEio EE ga| -~ lai Hy i$s0 E0ly GBSBE Paani Ahh BPeiggian llgee 13h mE 1815 288am 1g BDoELEBDog fi dB Sfs logdiugnent aha 3 8m 592% i gfHHeELiEEsEt EE LfhEe Gdidkn FEN Begg BF 3 Td Prey : Is 8] 81513 3 3 8 i2 1 2 2z Loa i oh EIB HE iz 8 io 2 5 i 4:8 1h 2 SE BEES sfg - En BE iy op phd s 10g iiafl gEnig P gfEEBF EEEEH 2 3138 gidfly oESnLEiR HE Eig pi HE pREEE 4 FFE zEelE BE ozg ED pgtEad i i : Ha 3 i = i383 : EE ; _i 5318 =8 8i15:3 g g 3 3 - g3 i i & PO oH z Pd i" 8 Pod g Poi id ~ ls ii iE z z i3i ri I dai BES 2 hselieddiee] EHH : of Hi8aiye : 13 siglo Eg bE diREE HDEFH EgEE RE,LE felSR H pgB EE 1205 sCihtyi ddizli gUiist dE gBrdcd dany EH &iEi3 3 3 8 i i :5 1 Lai gah dues PodLd iI gi 4 FH Pd dCoiRRlRTE IEii i 3 IfaEaEgiiEly SE5 PPo i FE3EE SigR8 gEgEiEiEeEiss 3IfHIdE ; siiiEgEEHlloy Sgg; EaEBtwEE,E SggpfEe Sg 3p8hEERa2E*IE 8EENgRa EE Hia: fgiiif PEyPoRE Slaabiie d 38 piEE BE HI, ggtaRe 4% Ei igi : Pffs digsi:l pslhnilnPgaisiiEf fo 5: BSiEgiEE cE5.% 5FE EE3E1f -NEPELgnesEsEL 2 $620 sTi i 3SEEEES2 ii: 38 2 Thi 2 23d HpiEglLE ,3 3: 24 -- 2g giiEfiiEd 33 3z 5 - : g 8 4 2 : i aa iPodd EL i 62E5 i vo i Pd 8 HI BRo : Sa ] EET: Po Hine ~ gsgls iGiio i if 7 PoE Gh 2BB EZ4FBHER cEReRiie <: 18 5, gs. B Pid aFEEjTig ERis Igf [SE ABFEoEE e 38 Fifd 0 EC BD pglhatiely $1 cit fie pha 82F55 z3 Gii% nei 8 i20 d dRg EBrEkGrtel aff2a4%Edirdeodress os 38 RHighid Eh Bdlk bBoafdaaly i aiff 5 iE 48 faE op inmREERR 4 g 7 siEdE i: e 3: 5 igis 3 3 ~ 88 grit 3 3 8 8183 z I a : IEF iog Eon 2 bo 8 bo 0oi ~ g : oHI It 3, 31g gialty 1Ba:o BoGiElL i3RR u eo 4 R3EDE jpuigdienBE i LE 3 Eq 8 GHoEinRgt a8 28fasxts dilly H GEUEEa EC.E eoanbtimh I dll phan EEG 2IB= ppd "lai fg g; l8 BBuRE2E86 t58ha8mEe8fgeErmts 222 Bqii#1d8 .5 BEeOdF EEoE fERE0E 5 ffHeGgAdSiRaEiEeSsE 8 8i : i i 8 3 ": & iy sing 9 Bigia * = = ~ 54 gifis 3 3 is 81&13 3 3 8 ~ i 3 gE i & g 8 i _ = id EEE | 8Jgi 11 iP:E Jfi< i 2 ~4 =8 og! EE gid gt fidbr f1o5e Hpohmamen. pGof gn gett opm Ho Silis ERENTSI PO FEN FT) SpPiiEEfiiEYl. Gg8RE8 gRgrAfiRn?E. o BBfEgREeRneRdnicGigeiEsf . GfERCplEl:l NEES i: iE glut 3 8 2 & glEi2 3 3 81513 3: 3 i - 3 iB 3 3 2 5 ' i 3 gi eels = io > ARgEEEz - gl 8 8 88 PrERERE EIT & iol a A8gB8ZEAES"F i ios! Gul gdm LEI FEL ff Dd LEH EMRE i Silly gf T5tr 4BdRgedife i z fiig8iiz% g8 g ZApBiEc . BfEoEBEhERchECC BE3 a od : ~ 54 gifis =8 815813 3 2 : 3 ]2 g 2 3 So i Lil ekafie SEEoi Eg5 aEeeEts g .: 1358 i5E 8BE wpRiERfEEiE 7fgy 92 gigi Bp SIghgheEt g 8 Bg Giliest dlBBmE 1a | 8 SifiT- 08 BRETT. 3g, Dg Parte PifiEiiE - ndgaand - gE Bit gieieaaz i Hf A & 2 81:3 5 --~ 3 3 : i :zi 3 i i Poo J s igoni L St E E Poi fHaiiaseia,d Sole2ig GgiREiEggEEr 4g1E : D Bg oifooer RHEuEeL fCfin ff fia fp sagegig spat 30 apn miguE, 42B%E& 8 $0 FRE edie igl Bon 53 igifivaiitsgaksg8d8 Lief i HfFESEEEGERS8 8OdAE"S TTI SIF iANAE gaghgqERel wld i= fod LIE gi: gu0 %4-g 88 Bee , E88 IE i52 = 9) digi - 28 gi8:0 zs gals & on 8 # }3 2 2 3 _ # Py 28:E83E2 ig v 1: LE 8 monde Ce 3 22 PiEieRiE . sdgfafiies gid &E5E p SHRHARAEEGE | o8fd &EEE wos 1 zg 8183  2 2 i g 8 io fai PL& oiRHI fii ; Egg. 8 gail . 43 31 on deat 110d 11 sigh phan fey 0 5 ss is --~ 54 EH Binh ledite BIDE gis fdr p SRORBRRRSE o Red FE il ge i5if gE @ : gifig 8i5iE os g z ERIE. EEE JE. 3E Eo oCo Po&& pHoE Si E00 g Pd ~ |ioi 33 388 i(LgBEil EBFfgE fHLEiT5 lTM afeirrgeide BBgeEeghitEaeiSsrs g3EegnsutgdiRfE3sE5cE8Ea8s 15. HFEEERF] !8 3 5 $ :&2H i Ei =2 Jd08 BpEhE e pPEPRmEE.L ffg o ip 1g1l 8= gi1v5i1i.g8dl8 Bidigsgs g Bi BydE cdas BREEETUOER 4 Fifi Leeaiie g~g~ 088 E1E0 52: PgiigFiigdaEaRl -gp GfREACNRRaRmEEReIfEt BiEgs Hi Ze iad os ii _ 2i:z gHiEH 8 : EH 818% 8 -3 3 iz ii& z 2 g 8 I] < 8Po LE et BEEa3"E _ Jf iPi h MEE ER3ES :N 83 E 5 pEF PgRiseHicehd 3i J1F1 pBiEx gp Hagadihesllry sfda B1DP0ioghpteisiatlt IilelEmmeaEs o0d 0 nlan Laie BH _ $i8 : ii 3} 5 bor coi i. 8& Pboo Hy isl 3 EITEERR] =2 = le iE BEER i : 3S83onyiEED BoBopEf dgYRrggaErteEidsEag,,l L1o0hgo 11 sigh pha og 8 nba andi GH i Blige Diag gL 2 givens gaRRgdEisl 4-REE 2 "i 3 i =8 815813 f8 3 ) fi g 3 8 s 4& Pol g Lo g ii i ii a8 F]I i dal = F554 88 EPERFNggEBE 2 Lo gS EEIEE FERRI LLC 5 2 iE Eg E SEE: a8 18 Dinos aetgatiely op EE Dios gdm nn a BE Ciiif.ef BgBudedad 3g E.o8 i$ i Bilan FOOSE Eee 2 BifiE%ET . igdE.ESies 38 E37. B, iiB i BEia Za PE 8 Hi E ii71 1) 8 g -- 22 28] gli 8ig:i3 3 3 3 I 8 J 8 : 3 & 2 5i El aHmaElelEs _ol Eh diEsee dd , feo mime 1 : i 2 18 8 Engg Eo 11 n, meld gid 11 gif apn 8 i L 31:1NE fDy E mmdE A b 0EChan [Z IERHIEEL C YHEeiTe P10 : Pili. fgEEREEEi: 2 ig i 3i3i8 5 ie 2 1 # 9 si ! 8 88:3 8 oo. i "2 8g 0 ielagisl Eo BEES, _ E id aBgEEse0 i a gq og 30 EB 213 Su |oRlae 1gl & z ooh diaiac8" IRiEa8E Bela mbaeed 8 BE2RE pen fgdmes EEE 0 SEEESGE g el dd 584 fig (C0 8 3 oF 8 i0 gai2, 83 i --~ 54 gE Zz 81813 E J 8 5 2 2 i 3z i Y 5 5 Bo EEE g Eoi TdpiEetaEns ~ JFFigBp BpREslEEg := i30i 13 GiE EED gia Bp EGREERREESEE Mghlnh 144g dJF BpiEiieERo8iD gmuSfEiaafRiaeelrEt Tp go 2: gH ififH E4OEE5R[C REARAE REFAHE 5g if Eg RE I: if 2 _ 543 Biaila gidid = 5 giEie : 8 2 3 2 AEE.] go Pe iP} ae i H1Y0 G2E 0BE opltim Foadf 1I1:]1 4d(051 f5BF Hpp.%eghifeEbanlyR pfioEd iesd 3B F88 aFLdiEineg dEDgElREuReEEs:s fC0oEiAlfs Jf| 0 w2EiigbBi3i8EM8h LganEE grAEE a3kE S808E003 8a i: fe iis: ~ gs 8iEi% 83 -3 = ! a i Pol i 8 ii Ea BES4 B ii pn SEi PPii EE 28E:fE astE 4If : fi pion gin, LE) 4% Eig oa Hak gc ad 91 ppl BOGIES iE BHE oE eL l HEE 1 LETHE h 5 8 4g SEI IL g yo L i Pi EC: gd gidid EH 81518 os 83 ! a 2 2 2 E Eo s Bo iil, 3 Po dh io elf i figs 2 io SLEEZRER 5 ~ le, EEE 1 , g| - iB LE -BEEagidet' LI d1 oan of dg, 3 2 gig ar FgoBatEaka 1VE: oosime f dads i5 E8 12S:E13TS]7SI FBgFlESE od fd gan (18 2: 3588 2% gidiiEdT ; ngaBEiEdE [BREE 32 Tid LH ifs 5 Ha Z8 815:3 : 1 i8 -3 3 a 2 2 ii . 3 EL 5 E: oii sioeask, SEg Tg Ag Eio HgEEFREaI 35 fo. : 1188 dEa Hon dpehbde BiDgl B1S0g:3 fgiiigisls80 FlBglBanaggdmend Hi Biocg .i% LJ EpEhaDn C EEL RE pnEdR dd ff2 s Fiiii EY%7 H. iEgdGdedRiiEes Ja2n.8e3t8 o8f4 no: i ho 52 gi | 3g= po< 5EB 0% 9% =| gigs i ] a HE i io Be PonNI gokgd Saf2 Pykoh BoEgts : 1g 0 8 fide [Eoin 5 FE LiEiEt-z dam BEGTEE 3 i I TI ied ~8 HE 8 ~3 i ii2 1 5 IRE | EEE HE hil E I o smaik dgie,s 5 ~ JB|: idialy pHsahilEiSCiSi ggf 5: BS| g8 gi4f gBY A[gRHgtEEesEcELE f4gg#4 d 353adHiiEaD n5gd BHpfgeegtilisdgr' HFpE oicziai 10 Jif Bete EjERE BE iritzgs gREggEas EEE 5% wififht HERG j Jolt 0 1 g4z wEiod gi g djiEEEHSEEE J1 _ 88 gidid i 8 8i%!3 3 \ :g o i Bfooiil Ei Sol @ Hgld galas 2 ae 11d ed a 308 iEiE, Bt of PIi8 oEaede EhRiEa Imb g (E1815 ENBgacBEr f-g i g g s siik is dpe | lil iokaag fDiiUohdhe EiE,SE RE HEE HGH EE 52 Lig $88 ; 8 HE] TH a --~ 23 iEi3i3 3 z g 10 md 0 i g Eoi afs g i: o o i828 - rE x HE gx io Iii i I, &iid2 33g8: ffgiiiigiir dIoNoEgnE IERIE 2 FE givin 9E. g208 f$Biiie%fliidyd fT$ai8ggEgD sf8 sBiIlLiE oi p mH l s 2 jile3g I ii(c:8 15: gof LEEPR ECoH; S.aE8kEs gaad EE8fE.88 ohf.m5 mBeERtEiR En25y.2 gS88EiRE3f5z58ii8 it gigi} g ~ 223 fgiigdiizd : ia iz5 i3 F a o: 3 12 2:. 8 1i 8 g _x i gE PCPo oi0 hHgillEti siBoioighhl,lfd UE 8 gehifen gen GgiLgEiE =: i5 88 pflF EpBRoi%EaRE zBEr gLohRedReadoipdd 3Ji8 fEliat GhEEaEESdE. dopf ERgeoilaeldcs Bi 001 glen en hilo 85 gitip dgaffefer drs dgiBadedsd o igm Ba sEiniiiTEh 3 s enigi i HoH 40 i i - 3 pif i : 8 | i 2 io HiT g i i 3 cid 5 4is 5, gioi z: sEkeEgt I&H n 18 GE, Fo THE ISFi i6hE op egfifdisn ISANES FpiHel F PEB RETR REais 55 Rp PEELED Had B15 0 Eoeangd Bnd BEEESSESES 2i3: EA i R 23E 5ET Eg3E2 8 2 3 3] 35 3 z a ; 3g LE < I hE gi 8 bo Bil gE 882 I oid dul . Sf8 iisfl E57y RdsEfiEBasEELf sg. : 131f7 81i igiEleBErD oapaf ohpgdRigsRilenRctlEyl Bln tfFooioFd:g (ify Ji F pmiiglliinsgisn EaRifeahdatn. 42 StiBiiEi8%hEgy. HBgME.IEREH H EEEEELS 88 l d3% HH SH 2 : 3 glx} : --~ E23 gigi 8 zPoii iE 55n 4 io fiigie - 88Eoi HE EaEiEZE.Eig8E gogiteaiy i 2 3g3 8g& iEEE10REBEDF 3fCgREfEEadmEgdsdEindgded G3 HEiaid . Ba silat alipmE 3iB8 pi2e1i8i.n0g3d 5.g8gdz5dodaEiF 19 aLo;% i3E8 ff HnEiHn H LiHmeH A fin -- 8 gigs 8 i fii Sil SEPolen h a aiE i :s 3388 gi5d B2% igguaERaEeLiER 4LniE $2 gia oop dghely fh HITEHI EF|I J sin pena 4 i Ping Pita BE 3 SEs 2 RERRRIE 58 = imped f - zg 21g: o g Co g i 4 a & . Poi Hii g Ei usb gis 3 ~ 8 0G0 E E252E33S48 ifi 2 yg iB OBE FE iis Pponpeh JER cl 3 giz gp nanEh fea 208 fiEbol pgiEabnelE Fadl 8 5 piliied feted 8% 4 wills Lita 8 iHo:gi HE iiis -- Zz 815i iz ; g To { iii g Co 3 Tgo i ii drFEEEw HE grieiid PLEoE afi.3hE36,EE 1 ff ~ B8215Hda gff JGEEE EOBELEES He iIf of a3 22 38J&gi2 HBgilSEEE2 dE EOeEEia C.nEE iD8ii4fd%l% 16 83g 2: i i233 8 ~ 488 iin dae gBiiffiigZdg3dfs -BIuEeEeR42E8uEz.sCE MEH ELE fapibaaiie sii se Bt-iiidd gi}3. Sigis dgii5z:ii0 00d . {-23:F 88 GfFf 5 oogfgd f 2 fice gE i5 -1 : i f z 2 3 g2 el 0 din abet --- JFEoyHI g pg.aBgafhpitgEies: HBgEdL 5 EL dl 3 dial fg 372 ciiBfig.sED EERE BE Einiial 53 TiE8E0E 2 gi 32:% HsEuIi dgtaigEy FpEgdmsdSfigeElErS LT dgEiEs 5 JRAGRRERE fe : TED a #B3r 8E%f od: LP Srp of JEEELE ILELH 1: 0f 20d i ig --~ 5 81Fi% 3 g 3 $l 2 i 3 2 & 2 3 2 5 Eo g Po od g8o Pl ah ra > FsReEEEAeEsE 5 i"k S3ALEgf & bo Po PEEEE WofagBE BEEZ, EE gg iB Png 0 MELEE $8 fizil HEED Gh Hg J3 pGgH ogafitgedlt oHuEn 0 ngifn $i MiDBiTy Ep8e4.d0EaE iGemen FL gEEBEAsy gu 3 80d 3% aiwl 8 HEE PR : 1 z EH gifig 3 2 = #3 81813 3 3 . --~ EF 3z ; 8EP o o Pol m2B5r% gqfd$ ~ ole i gE iomE Ed PiG5 2 Bhs digid amga=" 1293g fd 94 EVEE EitiiEs oa38d% g iehgeen'. 5i}d FBEIREREIE A5 foBE [of Bab Blais fay ER] 53 go PE es : 2 5 i2 i &i : 3 2 1 _ : i i 2 vo g i. 8 bo @ ogi 4: <EBE = } LE aw BEEa 2 Po a sid ~ gr HEE REEEL 2 Pi azhgaaE 2zEigEis = HI [EH PEE -IN EE 28 HE 3 EEau 3137 dHirzi EhEEaEEnCEkRE 8f,f BhigauEsdEs, B1e0 sGilEi iBy hijafd eLdidnige. i nll ph aly inti i: gSiEgid . E PEZERe ESNE ifokgf i- DEHERMiE 2: i2f3 LalIu E2 i2 2 -- ig gig 3 I : i i 5 \ i . Hpi! i #989 8. 8 i Pi q 4 cfp.aegsa8st 8 i ca gia ~ lg i io: gazsiz 3 11 in 3g is Lg 3 2B3F BiEfyL EBR EOEER Be p 2% d guiai gg IH Bg RE g 351 85 gERE8E 5 BEG oF. 2i3 BigifBo E -EoE RBpuiE etheBuf BRBfEing 23 gig o38 #888 i - 8 siEiE 81513 - : i3 ] po i 5 Pi PERsRE g ~ l2 eg ibEB EhSaSiE gi 3. 1810gif bbgi egghlgieeic i o1F: dsiitizipil Sbhbfanfll L1s1 i $iligfs? Fiota eset gt 2: f5 FIRER SERRER piu ~# Hi 8 3 i 0% 2z 8 g i 3i z EE LI EE TEJE ~ |g i, EE iH B1EE8wEERENT1I8LII8wd CHSREREN fLile = fis SWw E 4 3Hi2 oSidfpeEsE lpglgaiEelEr Bnrif2d Jf5 FFFE adpiivEsiiiE-aiAfRr 0 agaubfeamrlg lalk B85 5e0 s2olg : of Hinds flmit pofie o 5% HEEH johgietd f - giil cgiiiziisi :i ! Cog& Pi 2 RB dhe E402 shoadeks qd EF PELE] BgREg0e . :Poo gigs uGJElRESeRES BbP oLvovEiRESsRR 1 0g; Landy oo Grad 1PD00oipLinn dLGapoitiiedL1 nn GE bleidaeGd :: REA 3 gi 3% je 8 32 1 ~ 33 ii3 2 i 8 o i3 3 igoi Pi gsoiiknag 388 ef SE ERE. Elaine 5 HI EH SF wg, oBgiEge 3fg c8 ofaxiitdisEeEdigzg EigaRnEisnE f3g2 cEiEfT BBIRCEEEigd EmplaResnnad gg5 p(t1i5 ESRpE YiHI.E LGhHRiEign.eigg gi HREyE BeHpEheHlaEmS IHEORiEIEt 3252 gmilloos3s8 8EE8 8B3 4 Jel B - 3 81518 i HE i iq : oi FdiRnEgy - tw =: Po RbEED AREEERzEE Gf7 :> Bp ofpof ddl 1% Gia EafuieiE fo pii-tiitfnyeBls B3EfBaEdRagEsRr ied fii S200E8 is HH id (REE 1&3 gPiibgiiEfdetdEs - fBe,g.E.aE0ddBECS . AE83E3 % GREENE 5 fRgsianas FPG LEE i il 5 i 3 5 i i Biofleh EE OBS Pi mpl iPo Po 8 dal sik, a soingkn TEPo Lp aihEh BE :: 18 50 cilf o o |11 idE fBE d SEUAARg EEC JF fin ED mgtmgiielR 888 1Hd Br E30: J E5 grisaifipe 5dg BEapllhe HTT BEG dgBpdedsr 8GL IlEEEhe alniillaeiEgE EHPgili? Foti: id rE : : 2s glut 8 3 % HE gidi8 i -~ gg gigi :  ii 2 3 Co 3 P oli giiggsi aieb EE ~ IFh3 sli aHiiricaddd3h 0ix O2l3E:i8t8 z 8 Big BEE HE CR 1 pi PEREEI SG Lil : gigi 8 Bu% ogg fst EEAREE 2: Sido BYE GUESSNRES Ege gp IREREES FE ti wg = 5 8 ik : : 3 ~i 5 i z : 8 i2 ; 5E 0EE Bd . SE joli gE EgiEz gd nieE 5 d3p8 diGt3ih EgEEE gifiiild 00 His mR piEifg I8FElE5:E gigiia J dEEeCmH EERE &filg 1 F iptiyf odalte Hifsts&:oa gl gigi. Ease g-835 a8 ii SEE 3 fedds 5 Sis i 55 8p g 3iosee l 3 22 gifi3 = zg gig: gE oggi f g2 3 8: a 33 { i5 gE g Po z Po : i ha g gi i Ei 2 iPo d - IlRrE gE y SH ee ifPRyD: g 2HE] i EH5888 5 ih gg HEiTpEe SEZ IE 0 fRggoREeEiSpEtSR SBEIB.Bakaeug i !3 35 g; iaBE ZH3I i 3 11 @op dpb Lpogd HpdoopSiiligasLyE f3l 08BE LEE Fieiizds $58 Giia%iiaidss,ss & Fifideds 2325| gsTiiIfSEiiEfEEcAAhBTEE 2 gp dliGEEE pga BRS eEEgBpRtaaZtEaRsl PRoHE0RJzUaSmScERE p JSPEEEEREERR4MNEHRIEEEASSSEE fe iEEeCsPL i Rig dR BBE ogE.2 85 33 Ei EE88 2Bo8A2 o- RbRng-iEBt8h8adfo 3a dg ii Bef oe ao i iE gig! g 3 9 Sigiy : 28 gifi3 EL 8i&1T f 3 5 3 i Po da i 5 i gE.088d LL me, ~ Ele o BJREEREED OoHf .: 3sgg EiHB gf E=EE35.88 EiE { 3 38 dgiisd goHf HfEeREiREnC.E BLEE 3 10 GD Emel gr ITE 1 They pLIGE i ik gl 8 Joni dim fad J&2 322 2 2xH4E --2 SidibEsd BZEEE855S cE BE UB .u%@ REESE S2i1E8i1E88088F. agidd id ggiig!, sifid i%i3 BEER | 8 SgeE.EHCEEEe3s 2if: : 8 Beinn EE 3-EERJEELEoREEmR-Sd IE4 f2gF 258:g8 & 3 :8 :5 i g : ; i g Pi gi f iE ~ ls i 01g1:o j0iiE,b B2onBene JEFE diitis :8 i & g 5 dHEpdR iisk, seaogd SEHE GHaaiil. fie sa | , Dhl 5 Ba : i 5 mon89iF ELnL oBR iCBElEEE ogpainh nondg Bioanal of Sh jh en ik 1C1C na Bg.-Eedan fias HSenEdnLds E i TE EEeEl Cif a --2 iEi3 g 2 a t : 5 Poli ad - 3l2s 1318 iF 5bi o E B28y2 1 gidly dgSihpf ind amefr ; F# H 5oF ouB10 BoRp fel RE ar oaR 8 pKE EE Afgteane nglsed 4 RD Be ffnnE Loh g ~ FB z 151 48358 B En "g%a 488258, fgiifdiisd - f12e2a8s8t . SgFi-8Eafd i3i4f7 - BRRfIRNqE4EsS, Z| R153 3 3 ~5 g LL 3 gL Hk { i a i i 3 5 0 i i5 Eo gE, Ld 28 po Euka a8 8 - $8l=s HE iE GH22eE88 ligEzf 3 os g= E9o8. FfiiEgi;p EfagEl t 23p8 g H3Fa18 dHiE3nE I rEilalE l EE fg&FiL3i8E5 15 85 fPEpf MEE g No8 g"5 l C3 as d2 Jg fR PiirniD nn KEiffHs ai3E0ig iBEf Hihns i: soi: fEifg i1H3 B[iEoE D% A REER EE gid 2 <8 Blale 2 Er gif ET 81%13 32 - 28 : 23 z z g i Co he Eo Pi gi 4 [HI Bi z BEE dxEazds TLEEodel Lp ddgahfnaailate g4:E 5g 3a iiE egEp gfgiffsEEeRdEcRged ESEoEf 4 3388 qSiiafio05p% dpgglhagElaEdy Gfe1o iE |]3 dEigii,.pe3n% 2pRagrBine cst gg sod gg HH giE88 Linh dziivsiitiErssde wilh BiBgRdEydgEdas8 Lita oud E; 08JE. JU BBE ER Hilal 3}$I QSIiBEIiEdSERASE - jREERERRgEnEeEedl 5. cBEnEEzRELCERfEaREdgSisR i: gd HF iE ig: gl i23] Eo R fi : 9 EE BFi EH 15! i i &) Biaile = 22 giiE - Z] 8iEiE 3 ~: : ;8 [I Po1 Ei i Pd ~ ei EI fag gloalts aREEREg CLEELTT Co gnEE :2 3 i }33 i fHsis ERs 204f EE z DPE 8 I: Cqigud 30i dibniE iE Ltd gdgddaiprnieenn Bp Snioghds fREEEiSsRaai LsfLt gLeiEidghl: i3 F alT.Fng PlRa ES aafpt BaEnRNdAL 3% Bigid 5 E38 EEE ELIE I LEEEH HIN bEEx gi mio S 38 88 3 2 30 3 3i = 28 81513 3 3 :i 3 Po0 8as2 EEE izE4% --- TE2 REod SHE Ez fe iE, BEEO.T ELBEB BF Len VE gis Ep Bg oan gl LiEiS HE2GE 8 EF zivip defsE fggY- afws p[eEgtg EgaRre ZB.88% lilll didads ii EE I Hi i a = Aas g en 25 28 8&3 3 3 :8 23 -3 "| gs 3: i3 i0 LE i i be ed ~ 5 ii ol 2 ini fh id qo" iL =5 H3E8 oxii3Eiy mEEER gEfRE3RdE 1dg3FE fpoiifxnpdr dmOfEsEElE, s pgypgEogdld onzaisyggty ygdddfmtr 0000 EoErEm og JgBf efien Eloonp RR itA ion 0 os 0 2 id 3 2Id3 BgigEi LG8 24 EE 8] 81%: 3 gEEER SC & i& ~3 E 2 i8 i i & io Lo 8 HE i 8 Pd i Eon BEd 8 HEE RY daEadis sg gesEEage 5 Sr11 0 B0 RnEdEa g 18iofna fogpf Bmrgaianeedys sfda Bgonpet ogi fg 8HHI E5 g 7:3S 4 es Hl ie EE --2 S zpiisziiiffaaend ai2iEgf8augydagozdauseos"8 ihigeee fist Bgii18df1ii55f3E8iE7g-e| jf85Ee8EiRndEns8ea802 i 1: Bid 2 Hgiog! :2 gif, gifi3 81513 g8 s3 i3 . gBE hg iB8fe Ll if # 2ii 9102-4D5a1y6:GavSaugbcehSrodniyc iTnoxRiactistwyith OneGeneration Reproductive Evalations DuPon5386 APPENDIX O REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P; MALE RATS ~ -_-- `Company Sanitized. Does not contain TSCACBI ww 9H-02-4D5a1y6:GavSaugbcehSrtourdiyc TinoxRiactistywithOne-Generation Reproductive Evaluations -- REPRODUCTIVE TOXICOLOGY DuPont5386 INDIVIDUAL BODY WEIGHTS OF Py MALE RATS EXPLANATORY NOTES Notes: Test Days 75-89 = Cohabitation period - Company Sanitized. Does not contain TSCA CBI eee 9H-02.4D5s1y6:GavSaugbcehSrtonuidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPout-5386 - INDIVIDUAL BODY WEIGHTS (grams) OF Py MALE RATS Group: 1-0 DOSE: 0 MG/KG/DAY DATYeSs:t 7 8s 52 FS 106 ANINAL NUMBER 4433227309 6S0124.28 651389..27 652572..76 6s2e5a.l4s 6s4e8s.l8d saGa3312e8s4 561250055 e52a0.l4 54379.s2 e5e3d6.3y seesaillsl 664433129269 4s6a51.l50 4a8s0e1l7s 4assaslys ass026lls3 Sa1s3l3o 6s4a33127168 5S2e20a5 557353.64 s5s9e5l.s5 6s0e89.l03 6s276s.l0e 64433220870 556007..03 52728..77 552886..48 553388..71 sealiallss sasa33221711 562355..91 s6a306..55 6ss419l.s3 5&7s09..5s s6e7a6l.o4 sasa33i1ess7 6Se5s1.71 7s580..10 6S5926..5 760044..46 761167..04 sa433225412 S5e274.045 Ss9a1z1 e55r7..9 652673.12 6S371.19 s4a33114s7s Sse622.80 559774..92 05817..15 6e0x0i1s eea0nslizs ~ s4a33225746 687271.32 6s9a5l.e5 msie2llae 7522251s5 msellzs CompanySnitized. Doesnotcontain TSCA CBI - es -- H9-02-4D5a1y6:GavSaugbcehSrtoundiycTionniRcaittsywith One-Generation Reproductive Evaluations DuPont 5386 -- INDIVIDUAL BODY WEIGHTS (grams) OF P, NALE RATS GROUP: 111-0 DOSE: 25 MG/KG/DAY TDAEYSST. 7s os 02 9 106 ANTMAL NUMBER s6a433218887 456236..84 4G7a3l.s5 468600..63 469709..80 469955..93 663333127300 455750.053 sseusss SS38032 5s9a7.s3 6s1a0n.s4 64433124747 4S7076.83 1as9s.i3s 6a4s2.e7 s&o6a2llls 6s7u8.s7 sGaa33226114 SS686956 6s0e77..35 62s4e.31z 6s4e6s.l74 6e5172.l49 66a433216563 s5a29s.'1s ssae2a.r3 ssesoellas S57977.88 eseladlse 64433119787 s6s2a3.0z5 567387..21 654e3s..98 e558330s 659620..15 sa433i2e9s1 sS7a4s0 4s6e0l.l9 45792.l75 4e3l5a0s 467263.s3 64433122637 S51574.33 ss7295l.68 5s3e0a.l9 559373..77 650454..27 6343128333 4S6e5a.l17 0B2s7 459934..32 S6015.33 selleddz = 64433221693 s56a9.s3 5s9002..00 s61o5l.o5 se2a3s5 s6336z.l2s `Company Sanitized. Doesnotcontain TSCA CBI -- -- we 9H-02-4D5a1y6G:avSaubgeehSrtoundiyc TinoxRiactistwyith OneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL BODY WEIGHTS (grams) OF Py MALE RATS GrovP: V-0 DOSE: 100 MG/KG/DAY DATYESS:T 7 8s 2 9 106 ANIMAL NUMBER sa4z3i3s123 55616..63 $S1950..0 562074..81 653308..88 653366..46 sasa331341s2 s51s2e0l4s 5s2736l.s7 559373.37 esalillss 6s1s0o.l9s 564433129697 554473.040 sssee8l.s7 5s7s2i.17 s58saa. sSs6all.2s s3a32241s6 s5s027'.52 6S1146..76 652229..73 62s0s.l14 8S4s20 54433234051 456i65..61 4s7e41.l0s 4se8l9.0 4s9e6e.s6 469030..39 5s4a33220505 566001.17 6s0706ll00 Ess1z.04 6e3o7s.i4e 6604.037 s5a433125378 s5s328l0s6 sS4m6s3 s53e8s.?2 s5e3a8l.s8 653075.34 s4a332i2e7s s5e9a2l.s7 6s0ez4.7 6s1e6l.l0 6G2o6i.l2z 664106..00 sa433115564 40969.00s 6S1085s8 3S230s2 64asssil21 e4377s4 -- 543200 643150 5S2563.27 5S350165 ssisl2l.s4 s5a607l.s7 a5s6s3i.s9 -- Company Sanitized. Doss not contain TSCACBI we 0H--2D4a51y6G:avSaugbeehSvtonuidcy iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL BODY WEIGHTS (grams) OF P, MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY DAeYsSt: ANIMAL NUMBER s54a33127819 sa433125485 4433214681 s6a433228758 554433229794 ssaa33129222 sa433110610 6sa433228023 56s44a333332010271 7 8s 02 9 106 450336..63 4s3:12.l40 4s4e0a.l0s 4e4l9l.s3 46s2a726 547979.03s Sssaemls esissa. ese2s4.7 653726..17 5s0259.076 saasz7..48 5a6e7d..1s 4S176914 538977.007 a3%303l1a7 asosiles 450173.07 s8203ls8 5as3si0s is9710l50 Ss0os6l77 sse;lso ssaia s ssiilsa S541231s ssie2als7 557290.017 5S9376.l4s 650348.053 45s019l.s4 5a1s9s..2a 543885..35 459288..48 55025193.7 557183.34 59399.040 562569..83 5e734450 see7a4l5s 44a373l0s6 47amm32lls1 sdo7aolss Sdasaellel sseslss 53005 538s saals sass seols -- Company Sanitized. Does not contain TSCA CE ww 5204:5D1a6y;GovSaugbeehSvtoundiye nToxRiactistywith One-Generation Reproductive Evaluations Dupont5386 APPENDIX P REPRODUCTIVE TOXICOLOGY - INDIVIDUAL BODY WEIGHT GAINS OF P; MALE RATS -- ompany Senilizad. Doss not contain TSCA CE ws 9H0--2D45a1y6G:avSaugbechSrtoundiyc TinoxRiactistywith One Generation Reproductive Evaluations DuPont5386 - REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P; MALE RATS EXPLANATORY NOTES TestDays 75-89 = Cohabitation period - Jompany Sanitized. Doesnotcontain TSCA CBI me 0H2-4D5a1y6:GavSaugbcehSrtoundiycTionxRiactistywithOne.Generation Reproductive Evaluations DuPont $386 = INDIVIDUAL BODY WEIGHT GAINS (grams) OF B, MALE RATS Group: 1-0 DOSE: 0 MG/KG/DAY TaEvSsT: 78-85 85-92 92-99 99-106 78-106 ANIMAL NUMBER 864433223790 2m50a5 a12sls 120030 2s3e4 4s6s..02 sa643321848 13a0l6s a3s4s 1177as 11622 5s.e6s s6a433212996 115002 9 wF is R] 163 12004 asr2ils0 sa64s3211786 nwlio 2w00l1 1122ss 16ss selal.s 664433228007 11857a a517 110303 13628 aslass ssuussaann as1lao 11020ss 2130020 161ss asiellsl 64su3s119673 2304le 1l6ss 1sl7o 111340 selsys sa543322e521 137 216827 sslzs 11007 ssoasz s4a331i4s7s 1u505a w3m2l 11220072 1577a aalso - 6G4a33227564 112073 1as9lso ssis w14h3 eslaos ~ --- Sompany Sanitized. Doesnotcontain TSCA CBI wm F9-02-4D5a1y6:GavSaugbechSrtoundiycTionxiRcaittsywith One.Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF P. MALE RATS GRovR: III-0 DOSE: 25 MG/KG/DAY DATYESS:T ANIMAL NUMBER sa6433218878 646333213700 54433124707 s4433221601 6s4e3a1t8s3 54433119787 prsse3r2e0n1 4433212637 sa43312e333 ssaa33221693 78-85 85-92 92.99 $9-106 78-106 1530.27 17817 1108.72 eslss aessies "200 1a6l6s 1546h 123.16 assosn 18225 1203047 197008 a528 3es6iss 1i2o7 11863s 2122.26 1107057 aeslro s 11322 1m6lhs 1192 w1s5 esleois 21030060 7x6 2001 a7s3 n37l0s s2l1s ams7e 21210s4 aaslns a1s2sa 25a0s3 3si s a2lss a7lso s2o7las s2i0s zans 1usa 5791 s29s0s 2207 s1lss s5lss 5573 easscs - Company Sanlized. Does not contain TSCA CBI wm `H9-02-4D5a1y6G:avSaugbcehSrtoundiyciTnorRiactistwyith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF By MALE RATS ----------R--owe-- : v--0 ------DOS-- E: -- 100 -- MG/K-- G/DA--Y ---------- DEa5vs7: 78-85 85-52 52-99 99-106 78-106 ANIMAL NUMBER 4433311632 pre 2330.75 11200 126007 2s2s 205.00 1s alo 11 als saa s5a413311929 43267 u15zs s5l.a7 s1l7s s1lao sulsla 23 so 120 233 a0 Gsaa3322146 643245 22s1l2a 1s2l0o 2s2a1 4s7l7a oanlis 7a 1slo 26 32 268 664433320010 61883 119063 nslls a5l3s ssoslsa sa6433z1s5s7 Swas s1l1o eal2a 3s5a3 3s9ass 64433223287 17376 sslao 0o1s 1ilsa aarzs 4433116500 43156 26020 masiisa a1s0h2 120s3 42703 12s asin als 7s aia _ 54433129008 "3lss 1o3s 1ssllso swlaloa -1s000l78 Company Sanilized. Dosnotcontain TSCA CBI --TT ---- 9H0-2-4D5a1y6:GaSvuabgeehrSotnuidcy iTnoRxaictistywithOneGeneration Reproductive Evaluations Dupont 5386 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF Py MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY DEAYsSt: ANIMAL NUMBER s64e32m89 cSiai32s4e5 6G4a332681 664433227885 6sa43322799 4433129222 646433116901 6G4i332z0832 s88a44333233001127 78-85 85-52 92-99 99-106 78-106 235s07 2a065 189035 14958s;oe 21980ss 215680 1s0l0as 1704s 7saale 836207 26077 assil o1o0;s asiilss u1l3e5 1ess. 176s1 wazs asisa 8 177 9235 asl1o 1ass asroiss S2ol6s 11s70 wesls 1717 zeala 3sss 1a011 salss 0elss mas 2a8l0o7 220a3 21523 2s0ss msezn 32ss 2607 27031 11007 140s7.0 es ss sls mz 30 - --- Company Sanilized. Does notcontain TSCACB wm H-24516: Subchronic Toxicity 2900--DDaayyGGaavvaaggeeSSttuuddyyiinnRRaattsswwiitthhOOnnee.GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt:5386 APPENDIX Q REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P, FEMALE RATS DURING GESTATION EL Company Sanitized. Does not contain TSCA CEL -- 20H9:02-D4D5ea1yy6G:GaavvSaauggbecehSSrttouunddiyyciTinnoRxRaittcisstywwiitthhOOnneeGGeenneerraattiioonnRReepprroodduucetiivveeBEvvaalluuattiioonnss ____DDuuPpoonntt:55338866. _ REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P FEMALE RATS DURING GESTATION EXPLANATORY NOTES Foomotes a b NNooligtetsetratdieolnivdeartead;sidnacteaneoxccloupdueladtfironomplsutagtiwsatiscaolbasnearlvyesdi;s.no litter was delivered. 4 DNoaltitveortdceollilveecrteedd,dhuoewteoveerr,rimplants were observed at necropsy. Datawas excluded rom statistical aNnoalygseisstation data since no plug was observed, however a litter was delivered. J&f DAcacimdedneltiavlelryekdilplreidorTetsotcoDlaleyc9ti1on(DoafyDa1y4G2)1. body weight. --~ - Company Sanitzed " Sanitized. Does not contain TSCA Car Tw 9H-02-4D5a1y6G:avSaugbeehSrtonuidcy TinorRiactistywith One-Generation Reproductive Evaluations DuPont-5386 ~ INDIVIDUAL BODY WEIGHTS (grams) OF P; FEMALE RATS DURING GESTATION GRoUR: 11-0 DOSE: 0 MG/KG/DAY GEaSTvAsT:ION 712 ANIMAL NUMBER s4a333z4s32a 2370461.21 23s2a0l.s5 333292.034 332924.47 6s4a333a9ss48 5310821.32 333535078 saesa2l0s 478.0 dass 6644333381090 30-46 33-87 363-.5 as- i s4a333365308 633.6017 3316.10s 342070.13 341786.s2 sa6433a32917 s269a05 330312.072 33639.053 -e -e s4a334a1z908 33675.68 13905300 2268..82 3s9a7.l9 sas3aa310a1d 236390s6 23s1slss 431362lss 3a7l00y9 664433337585 23891015 331833l3s 431490..92 aaamails7 6644334349735 322-.0 350-.3 394-.3 -- c - 64433437886 2288710077 3300s8l105 333a70.l5s 4a3z36..17 -- -- wo Company Sanitized. Doesnotcontain TSCA CBI H9-02-4D5a1y6G:avSaugbechSrtonuidcy TinonRiactistywithOneGeneration Reproductive Evaluations DuPont 5386 = INDIVIDUAL BODY WEIGHTS (grams) OF P, FEWALE RATS DURING GESTATION GROUP: 1v-0 DOSE: 25 MG/KG/DAY GeDsaTyAsT:ION 712 ANIMAL NUMBER 564433339390 23027.a2 3a4r1i.a6 3s6e6l.s8 447-.e7 p6r4e3r3e69 3320790178 a35s2i0ns 3e8e6l1s7 499-.c2 6s4a33435802 33051008 33a705l.s2 341725033 s43u7.o9 6s4a333a3a85a 33016ss 3a2i5s.l8e o4a5s.e9s 440282..77 554433131285 330633008 03345..76 e38a8.s7 assssi.a5 sasa33aa0r3sae 207-.8 323-.0 33-.3 a-s 6G4a333a7262d 3s8s90s0 33376825 4s0e1s.s0 400C.F1 66a433a35725 3331605107 339758137 3389321093 a30d6s.l7 66433347020 32155.a4 3283791035 s32e2l0s8 aasmsiss - 663433335557 230875.027 331361s7 333698..38 --ee - Company Sanilized. Does not contain TSCACBI wm 29H00---2DD4a5ay1y6GG:aavvSaauggbecehSSrttouunddiyyciTinnoRxRaiatctisstwwyiitthhOOnnee.GeGneenerraattiioonnRReepprroodduuccttiivvee EEvvaalluuaattiioonnss DuDPuoponntt:55338866 ~ INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY eDsATYASTION 7 fn 21 ANIMAL NUMBER 6s4a333a2s0aa 321028.055 33382.6 332761023 3a0n8.e7 s4a334a3z9e 2320140s4 3328711s5 3367090012 aasesaisz 5G4a33335s3sa 331000040 331426l8s 338311.67 43s021.s3 p6r4e3v3e3e5t] 237044.127 238383101s 330s16 296-.&6 sa5433a313e7 a2s7l1os 3sa1l 327970057 Ze aes. 5s4a33430s77a 2372860162 3258831043 240857.135 e 202.7 646433343217 2na7lss a3s3s0i7s 333636ss 3a6l1o4s 5544334437400 207-.8 338-.5 362-.3 asa-.e s5a433a3s3a9 3310245131 a34s2l2 3a7m60r0 ase-.7 - 554433333630 2360651046 33311175 3sa6sas 3as7il3e.0 - Sompany Sanitized. Doss notcontain TSCACBI wm 9204-5D1a6y:GaSvuabgcehvSotnuidcy TinoxRiaciistywith One-Generation Reproductive Evaluations DuPont-5386 --~ INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY GEDSAYTSA:TION ADHAL wUMBER ei6433144637 64433441173 644333333580 si6z43a4c4e0 6ca43344330125 664433332665 s6a433332785 pr4e3e3n46s) 6ci433a4z495 643420 o 7n2 22565.060 30109.s8 334356.02 4461.s3 3a1l0s7 330674s1 3a9192 aasisley 235-i 322-1 sal:e ari:s a22l0s0 33207006 334673..33 vas6o.6 27:24 28>06 282:12 267..0 3328.'0s 335205018 336620.80 aa3sssiias 3S0a2i0s1 3ea6l071 saeoaas e 3260570.75 22766036-298304 2e3-.g7 332480011 6318s0 3s0e6l.s4 3a1s4s 208 267.8 201.8 283.8 - we Company Sanitized. Does not contain TSCA cat 22H00-:2-D4D5aa1yy6G:GaavvSaauggbecehSSrttouunddiyyciiTnnoRxRaiatcsistwwyiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt-55338866 APPENDIX R REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING GESTATION Pa - Company Sanitized. Doesnotcontain TSCA CBI we 012-4D5a1y6:GavSaugbcehSvtoundiyciTnoxRitcstywith One-Generation Reproductive Evalusions --- REPRODUCTIVE TOXICOLOGY Dupont 5386 INDIVIDUAL BODY WEIGHT GAINS OF Py FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a Nolitter delivered; data excluded from statistical analysis. b NDaotagneosttacotliloenctdedatdauesitoncceron.o copulation plug was observed; no litter was delivered. d NNoolitgteesrtdaetliiovenrdeda,thaoswienvcere,niompplalnutgs wwearseoobbsseerrvveedda,t nheocrwoepsvye.rDaatlaitwearsweaxsclduedledivreoremd.statistical analysis. f Dam deliveredpriorto collectionofday21G body weight g Accidentally killed Test Day 91 (Day 14G). --- ompany Sanitized. Does notcontain TSCA cat ww H9-02-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont5386 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING GESTATION _-- DOSE: MG/KG/DAY GDEASYTSA:TION 07 7s wm om ANIMAL NUMBER s4a333345320 2220.28 128004-1762060 11260.26 psrae3saests] 337.64 21601s3 sseso 1a89n.v7 pr64e3v3e1n90 3021 280:8 se2r 17:0 544333365308 25a091 318633 7o6a4 13192a 46a333a9271 as1e w37a8 -ee --ce 6644334412508 33724 32230028 12085.73 137:6213 663a334a011ad 543455 33700083 3a3l0s0 nsaesae 1287117 3208 263 1045 163.6 6644333379830 23~l8 3-6s sao 112.:4 - ssaa33344778 22823 asals0 s-ac asi-ac Ga33ss 2003 29s ssz 190 Sompany Sanltized.DoesnotcontainTSCACBI _-- 08 H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ~~ INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING GESTATION -_-- GROUP: 1V-0 DOSE: 25 MG/KG/DAY GEDASYTSATION 07 7-4 wer oem ANIMAL NUMBER 643399 643334 34.4 25.0 25.2 412 80.5 40.5 -c -e 6s4433d36649 4202..46 3384.34 1-2c.5 189.-4c 664433439402 32990.44 3375..15 6928.70 113e6s.29 6644334434858 1243.0 2109100-162218 13002029 664433a31285 3s1lss l2i80o5 16866..86 114971.036 6443344709388 25-.2 103 19.4 16.1 s644333a7262d 2250.36 2362..44 R - EY-f 646433447552 32890.66 1s6i6s 52380 1401902 664433347020 2l4s5 135815 11391.20 1s7l2o --- 664433435975 3227.07 22.6 2809 -c -c le -c - ompany Sanitized. Does not containTSCACEH ws 0H--2D4a5y16G:avSaugbcehSrtoundiyc TinorRiactistywithOne-Generation Reproductive Evaluations DuPont$386 - INDIVIDUAL B0DY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING GESTATION _-- GROUP: VI-0 DOSE: 100 MG/KG/DAY GEDSAYTSA.TION 07 724 mem on ANIMAL NOMBER s6a43338280a 2226013 3125.16 1672..60 12109.578 664433843258 23720057 332003s 1706303 1le3sss 6644333358350 3284s aaslls 27907s 14a2l.s3 6sa433a3n3s9a 2B8l0e8 3m00l4 s s-oe 22.l4e sa6433a31367 2206016 32860.46 sse. 13.l7o 6644332305772 332072 seal2s -aes 4le 66443332317 22370017 2a0207 aaraae 10ssslss 46433443700 a1: ma: sa:s astr:o s6a433a3s45a a29l0o9 aollss 122-e.7 1saleeo --- 664333333630 a2l2i1 3las 2ee7r5 110463..62 - Company Sanitized. Does not contain TSCA Cay wm -- -- H9-02-4D5a1y6:GaSvuabgcelrSotnuidcyTionxRiactistywith One-Generaton Reproductive Evaluations DuPont 5386 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING GESTATION GRovP: VIII-0 DOSE: 250 MG/KG/DAY GDEASYTSA:TION 07 714 wm om ANIMAL NUMBER 664433434637 4433441137 s4a3333338se s4a334a4s0e 6s4a334a33018b 6s4a3333266s 664433337285 6644333343680 663433343299 saza2aa 4a3s.l2s 2slss o79na 11s6e0.17 2323026 a3l8o3 s9a6ss 1lead 2-67 3-2s s-as 18-23 3352s 3s7l.s3 w9i3.z0 1e6d6ise 5- 2 1- 6 si- z sla - 312013 3169.09 selsse 11166.5 a8sl5o ellss --ee -ee 1a0l0s3 73.4 033 18".50 3a3llss aaelss 1m0l70zs 16ss.s 2700 slo 20 ao -- Company Sanitized. Does not contain TSCA CBI wm -- 0H--2D4a51y6:GavSaugbcehSrtourdiyciTnoxRiactistywith One-Generston Reproductive Evaluations Duoni-5386 APPENDIX S REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P, FEMALE RATS DURING LACTATION - `Company Sanitized. Does not contin TSCA CBI H9-02-L4D5a1ye6G:navSgaugbechSSrtouunddiycTiionnrRiRacatitstswywiitthhOOnnee-GGeenneerrastiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss REPRODUCTIVE TOXICOLOGY DDuuPPoonnt.-55338866 INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes. a Nolitter delivered. b Nolte delivered, statistical analysis. however, implants were observed at necropsy. Data was excluded from d Found Dead Accidentally Test Day 99 (Day 22G). killed Test Day 91 (Day 14G). Founddead Test Day 106 (Lactation Day 0). - Tw JompenySantizd. Does not contain Tsca cay H-24516: SubchronicToricity 90-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPont-5386 = INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING LACTATION Grove: 11-0 DOSE: 0 MG/KG/DAY LAaCTvAsT:ION ANTAL NUMBER 712 s6a4333354328 297-.4 315-.0 335-.8 336-.3 6sa433a359940 360-05 37:84 3s22.7 37!7i prseav3e3n1)08 331-.7 383-.2 361e.0 330:.8 4a333365308 367-.4 380-.0 392-.4 37-91 s6a433a32971 33526011 33200012 2s3e.l8s 32866.13 s64a334412908 412-.6 398-.0 414-.8 402>.9 sa433a011ab 32:.9 32:00 3383 .7 : 320.0 sa4z3a3s7s8 330ssis 3327720022 339853039 a37n60e7 - psar3e303a 543478 387-.7 376-.9 387-.2 365-.9 32005 321s 355s 339 sa3386 32900 3392 347.9 sais --- ompany Sanitized. Does not contain TSCA cB ww 9H02-4D5a1y6:GavSaugbeehSrtonuidcy TinosRiatcsiywthOneGeneration Reproductive Evaluations Dupon-5386 - INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING LACTATION GRoUE: 1v-0 Dose: 25 Mo/Ka/oAY LADCATYAST:ION ANIMAL NUMBER 646343333989 sipr3e3e6e9 s5a43334a520 ssaa3zas3a8sa 6s4a333a2l5a Gi433aa70528 r64e3v3e75 ssaa3zai7s2 584433347020 sisa3334597 o " 14 2 3208.'9s 3e:l2s7 330770.067 aazs.so 3360928 3s0l60s1 wdeesins d3e7n7iss 3325s07 3613 33s9aa0s5 3ea9ee7slllsan se3i5ll3oe7 32-.7 Bsa a3lss 2a6np8a1 4608-..7 3-2 01- 7 37:02 se~ls 3323-0.79 337-.a0 3s7-a 337656-..09 3637090 rmallss 33s7a8l3o deeealrs 333061142 30s 0a32ss2ss ddaaaeiassr a3s5me0.ao8 --- omPpany Sanlizad. Boosnotcontain Ts cay w H9-02-4D5a1y6G:avSaugbcehSrtoundiyciTnoRnaitcistwyithOne-Generation Reproducive Evaluations DuPont-5386 _ INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING LACTATION Grove: vI-0 DOSE: 100 MG/KG/DAY LADCATYAST:ION o 712 ANIMAL NUMBER 6s4a33342808a 36-.8 371-.7 370-.7 367-.8 56433412389 335543.081 337543..90 3379a.l66 338e03l.06 63433385530 379-07 37-.0 393-.0 3s0..3 64c3a3a3m9aa 36-.5 346-.9 7.2 5 353-.0 646433333176 336370.087 337139.05s 338590.021 3a6i1l.s7 6644333305778 36- 1 328-.4 34.14 3560-3 664333343217 229982.079 334385i.:0 3s7a9.z3 337289.032 644333437408 335..9 355E.2 376-.9 360-.8 6s4a333a4s5ac 35.41 369-03 390-01 3es- .z _ 46433333630 237803.066 33a113..23 33573..20 a36e0.s0 -- - `ampanySanitized.Doesnotcontain TSCAcay 9H024D5a1y6:GavSaugbehvSotnuidey iTnoxRiactistywith OnGeeneration Reproductive Evalutions Dupont5386 - INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING LACTATION Rov: vITI-0 DOSE: 250 MG/KG/DAY LaDcATYASTION ANTAL NOWBER sassi3i3a3isia77s 554433431338 8p4e3335 ssie33aa43000 siszasszansa rssi4e33e33r7258 sic3i3z3aae8d2 s6i43s1s4a5se anna '12 3ss5ie.ee3ns 3a40m0sll1s a3s2seos s230a98s0..34 Sse2l0s2 ssaasa saemlss essree Ssi2s8l7s smellss wdaosa ea1lslas Ms: s 0:2 sa! s 30!0s 36-.2 se- s as- a de- s 3S56733023s sdselaeass aeesmsiass asdmisezsn . :: : :> 3.: 0 : wo: . : am: a : am2 a : _ -- Tw SompanySsanitzad. Doesnotcontain TscA car H-24516: Subchronic Toricity 90-Day Gavage Study in Ras with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX T REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING LACTATION i --- Tw Company s,enitzed. Doosnotcontain Ts cy 910.-24D5a1y6G:ovSaugbcehSrtoundiyc TinoRsaitcistywith One-Generaton Reproductive Evaluations REPRODUCTIVE TOXICOLOGY Dupont 5386 INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a Nolitter delivered. b No litter delivered, however, implants were observed at necropsy. Data were excluded from statistical analysis. Found Dead Test Day 99 (Day 22G). d Accidentally killed Test Day 91 (Day 14G). e Found Dead Test Day 106 (Lactation Day 0). _ - SompanySanitized. Does not contain TSCA CBI ew 9204-5D1a6y:GaSvuabgcehrSotnuidycTionxRicaistywith One-Generaton Reproductive Evaluations DuPont-5386 --- INDIVIDUAL BODY WEIGHT GAINS (grams) OF ?, FEMALE RATS DURING LACTATION GRovP: 11-0 DOSE: 0 MG/KG/DAY LDAACYTSA:TION 07 74 wm om ANIMAL NUMBER 644233354238 - - a7 16.7 . - 0.5 3.9 [4e3r3e902 - ls - ls al. s 1-0 644333318908 2-s 7: .8 30:.2 0.: 544333365308 12-.6 12-.4 cm- a 1-7 s5a433a3z917 sloso -3s60a3le 22053 asslo 6644334412908 "4- 6 16:.8 a1 92.7 4a334a011ab m-2 a-s 7- 1-a 664423347585 720173 13671 auose 1oa2sis 644333349732 so- s 1-03 21J 3 21. s _ 554433437886 10i0o2 a5l7o cl6ss 2185l3s -- Company Sanitized. Doss not contain TSCA CBI es 9H-02-4D5a1y6G:avSaugbcehSrtourdiyc TinoxRiactistwyith One-Generation Reproductive Evaluations DuPont-5386 ~ INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING LACTATION GROVE: 1v-0 DoSE: 25 MG/KG/DAY LDAACYTSA,TION 07 2s wen om ANIMAL NUMBER 654433333349 pr63e3v3e6n9 64433340520 prseavaeansa sa6433a31285 6644333407398 6s4a333a7262b 664433445725 654433330702 s5a433a3s975 1w8e3 23.a9 1ea5s.7 2610ss -f3s7a 7292l615-200si2s 217707 2"0a032 23030s5 3a4l7o z0a2l 3- 6 a-ls 16- 7 1-s s0ol7s 13807 c2ae17-269037 se-ls e.ss cl- s 1-7a 6:s 3:s 5:.0 232.0 9s.74 4m1l3s 0sa4 sa0;3 a2s1l 2m023 21736 1se4e 2930 1w9ml 1z4aa 12463 -- - CompanySanitized,"Does notcontain Tsca cy ww 10-2D5a1y6:GavSaugbcehSrtoandiyciTnriRcaittywithOneGeneration Reproductive Evaluations Dupont 5386 -- INDIVIDUAL BODY WEIGHT GAINS (grams) OF Py FEMALE RATS DURING LACTATION Grove: vI-0 DOSE: 100 HG/KG/DAY LAoCaTtAsT:ION ANIHRL NUMBER 64ci333a2s00a Gi5433a42389 5s4a3m3e5s3a 64Sa33343792a 6G4i333a3176 GiGa33a305778 4433343217 ss0433a437808 si8z43a3s4a9c 8s6433313630 07 7a wm om sao a05 2p as:o 0"0i a1sls 1m0i0s assles si-r asl-o ma: al:s e:a olpe asfts us: ailsas sols aeres olwollss 13: 10: 1sL 3a: a50l3s : 3e4ps3 zao0: s36e:3 1193023 22008 eaens aitlas s7o0l0s6 0: al:a 39lr 7 76:a ea ~ --- Company Sanitizad. Doss not contain TSCA cat ww 9102-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywithOne Generation Reproductive alton Dupon.5386 - INDIVIDUAL BODY WEIGHT GAINS (gras) OF , FEMALE RATS DURING LACTATION Grove: vizz-o Dose: 250 HG/Ka/oRY LaacTean:ron Anas wovsER SSsaai2334461s377 pSar4ea2s4sa GiC2ide0 SSSiiiaaesi2st60ea SaGaiaanreas prCG4ie33e4s4an5eyd SGiaa2ias2a0a0 07 7 am om 0 1a5s2 z1C2se7l oasenasas oassossa A B 20 E as n so Tdmeailn eBT35ene aS1 EE an :: nenn : wNnl : was: aBces asB oun asBs EBS 2vo oaMo :: wehe andad :: vNe : al3e ca: -: aa: B BE B B - -- CompanyanysiSanitized. Does otconstoaaicany wm `0H9--0D2-4Da5ay1y6G:GaavvSaauggbeceShStrtouunddiyyciTinnoRxRaiacttistwywiitthhOOnnee-GGeenneerartaitoonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonnt-t55338866. APPENDIX U REPRODUCTIVE TOXICOLOGY ~ INDIVIDUAL DAILY FOOD CONSUMPTION BY P, FEMALE RATS DURING GESTATION --- Company Sanitized. Does not contain TSCA CBI Tw H902-4D5a1y6:GavSaugbeehSrtoundiyc iTnoxRiactistywithOne-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont5386 INDIVIDUAL DAILY FOOD CONSUMPTION BY P; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a Nolitter delivered; data excluded from statistical analysis. b No gestation data since no plug was observed; no litter was delivered. No litter delivered, statistical analysis. however, implants were observed at necropsy. Data were excluded from d No gestation data since no plug was observed, however a liter was delivered. e Accidentally killed Test Day 91 (Day 14G). - Company Sanitzed. Does not contain Tc cay ww 290H0-:-2D4Do5ay1y6GG:aavvSaauggbeecSkSoutnudidcyfiTnnoRvRaiatctsistwwyiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt:-55338866. -- INDIVIDUAL DAILY FOODDCUORNISNUGMPGTEISOTNATI(OgrNams) BY P, FEMALE RATS GROVE: T-0 DOSE: 0 MG/KG/DAY GeDsaTyasT:ION 07 2 wen om ANIMAL NUMBER s54a333345328 543459 2200.05 a25s.i8 a1s9l.o8 2233.074 2613 2707 252 264 6644333389002 2175047 o3a0si0s assioa 21a82 5443333159004 26: 26-3 ae: 23>2 64333336537 2s9l0s6 3221s 2380a1 3207.07s sasa33aa22018 233s3 m3sls 22602 saolls 6s4a334a1n9ae G43401 330008 2302032 32:326 2nls1. 2sls 20 2904 2800 664333335758 22370'2s 3nlas zles 22893. 544333349735 22.22 31:4 30:s 29-. - s4a33437s8s 2a8l5a3 22227 2m6s3 2a6l3e _ Company Sanitized. Does not contain TSCA CBi-r or -- 2904-5D1a6y:GaSugbechrSotnuidcy TinoxRiacittywithOneGeneration Reproductive Evaluations Dupont 5386 - INDIVIDUAL DAILY FOOD DCUORNISNUGMPGTEISOTNATI(OgrNams) BY 5, FEMALE RATS Grove: 1v-0 Dos: 25 Mo/Ka/oAY cEDsATYAST:ION Ane NowseR 07 71 wen om i43333399 Gidaes 32s1 2al5o mams 2as6ia 23s 21 wma ss csiis33e90 si3342 2aiss 2297aa 2241s0 salesls ls oasis a aals ssaise3s3aaai31s88a 22064 3sl2 228:24 265 2s6sa aaa 3203 oasis p8r4e3v3e2r5d FES.O CH: : EH: cei333a703a sie2ze 22.69 m2asls 2w6s4 msaole 2001; ah ae s4ia33343i77s52 236107 als wasaz zm aeasa 32s aasrle sa - 580033349050 S015 3al7o 22as azsilso 2als43 ls 2els 264 ses EE SompanySanitized. Dos not contain TSCA caf -- 02-4D5a16y:GavSaugbeehSrtoundiyc TinoxRiactistywithOne-Generation Reproductive Evaluations Dupont 5386 ~ INDIVIDUAL DAILY FOOD DCUORNISNUGMPGTEISOTNATI(OgrNams) BY P, FEMALE RATS GRouP: VI-0 DOSE: 100 MG/KG/DAY GBDsATYASTION 07 74 wm oa ANIMAL NUMBER sa4331382802 2262.s8 3224.24 21965s 2291..62 sa343a42389 2255162 22s1l7s 2268711 2276..47 sa433z3s5s3a 2280003 32040 31803s 22900.66 saca333a3793a 222638 227:1268 218570 227:.37 646433333176 2203135 2279l8s 3231.04 22600048 644333450772 217705 3m0027 21628 21090a8 664433333217 222l0s8 2257.20 2233.4 2234.17 644334437000 300: 0 28:0 26:3 : 28a 6s4a333a3s8a 2265067 2268017 226s06 2247.16 - 646433333630 2263189 2296008s 2266 227.68 - SompanySaniized. Doesnotcontain TSCA CBI ww 9H0--24D5a1y6G:avSaugbcehSrtoundiycTionxRicaistywith One-Generation Reproductive Evaluations DuPont:5386 - INDIVIDUAL DAILY FOOD DCUORNISNUGMPGTEISOTNATI(OgrNams) BY P, FEMALE RATS GROUP: VITI-0 DOSE: 250 MG/KG/DAY GDESATYAST:ION 07 7a een oa ANIMAL NUMBER 654433434637 3252015 3260123 2337s 3as1i3a 654333481137 22790001 a2sl8s 21a8l73 2oa5s.i5s 6534333333850 250:3 as;l 3:2:la 280:0 s54a33334608 2286075 223.l7s a2ssls3 2278s2 6643344331008 as:a 21: 1.:3 21:6 664433332665 1 2906 a307ls 227700 2297020 664433337258 23070s m32l.n2 l27o.0 22s9l9s 5644333324588 21630 2 36s62-:e 24l0e [Grae3vae29 231s0 228631 218.38 a28b07 -- ca3a2ea 14 27 20 a0 ---- `ompany Sanitized. Does not contain TSCA CBU ne 9H-02-4D5a1y6:GavSaugbechSotnudiyc iTnonRiactistywith One-Generaion Reproductive Evaluations DuPont-5386 APPENDIX V REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P; MALE RATS -- Company Sanitized. Doss not contain TSCA CBI TI05 -- 9H02-4D5a1y6:GaSvuabgcehrSotnuidcyTionxRicaistywith One-Generaion Reproductive Evaluations DuPont-5386 _ INDIVIDUAL CLINICAL OBSERVATIONS IN By MALE RATS GROUP: T-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER. OBSERVATION FOBISRESRTVEDDAY LOABSSTERDVAEYD saaz39 43270 sa3148 643204 643229 e319 643176 sa3218 643207 643280 sa32m sa3am1 54163 43197 NSOACARBIFNIOCREMDALBIYTIEDSESIDGENTETCETSETD DAY 107 SNOACARBIFNIOCREMDALBIYTIEDSESIDGENTETCETSETD DAY 107 SNOACARBIFNIOCREMDALBIYTIEDSESIDGENTETCETSETD DAY 107 SNOACARBIFNIOCREMDALIBTYIEDSESIDGENTETCETSETD DAY 107 NSOACARBIFNIOCREMDALIBTYIEDSESIDGENTETCETSETD DAY 107 NSOACARBIFNIOCREMDALIBTYIEDSESIDGENTETCETSETD DAY 108 NSOACARBIFNIOCREMDALBIYTIEDSESIDGENTETCETSETD DAY 108 NSOACARBIFNIOCREMDALIBTYIEDSESIDGENTETCETSETD DAY 108 AALLOOPPEECCIIAA BROITGHHTFRFORONNTTPABNA(WS()S) SACRIFICED BY DESIGN TEST DAY 108 NSOACARBIFNIOCREMDALBIYTIEDSESIDGENTETCETSETD DAY 108 NSOACARBINFOIRCMEADLIBYTIEDSESIDGENTETCETSETD DAY 109 NSOACARBIFNIOCREMDALBIYTIEDSESIDGENTETCETSETD DAY 109 NSOACARBIFNIOCREMDALBIYTIEDSESIDGENTETCETSETD DAY 109 NSOACARBINFOIRCMEADLIBYTIEDSESIDGENTETCETSETD DAY 109 s9s2 1088s --_ -- Company Sanitized. Doesnot contain TSCA CBI ww -- 9H-02.4D5a1y6:GaSvuabgeehrSotnuidyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 o~ INDIVIDUAL CLINICAL OBSERVATIONS IN 7; WALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANTAL NUMBER OBSERVATION OFBISRESRTVEDDAY LGABSSTERDVAEYD 643242 SNAOCARBIFNIOCREMDALBITYIEDSESIDGENTETCETSETD DAY 108 643251 SNAOCARBIFNIOCREMDALBIYTIEDSESIDGENTECTTEESDT DAY 109 643155 NSOACARBINFOIRCEMDALIBTYIEDSESDIEGTNECTTEESDT DAY 109 643147 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 109 643276 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 109 643254 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 109 -- `Company Sanitized. Doos not contain TSCA CBI we 0H--2D4a51y6:GavSaugbcehrSotnuidcy TinoxRiactistywith One-Generaion Reproductive Evaluations DuPont 5386 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py MALS RATS GROUP: III-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER oBSERVATION OFBISRESRTVEDDAY OLBASSTERDVAEYD 643207 sasies 63230 643170 preeen 643277 pee sa3261 643166 sa31s3 643177 sa3198 sa3201 a318a SNOACARBINFOIRCMEADLIBTYIEDSESIDEGTNECTTEESDT DAY 107 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 107 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 107 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 107 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 107 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 108 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 108 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 108 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 108 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 108 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 109 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 109 SNOACARBINFOIRCMEADLISTYIEDSESIDGENTETCETSETD DAY 109 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCBTSETD DAY 109 -- EE `CompanySanitized. DossnotcontainTSCA CBI 0H--2D4a51y6:GavSaubgcehSrtoundiyc iTnonRiactistywith OneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL CLINICAL OBSERVATIONS IN P, MALE RATS GROUP: 11-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY LOABSSTERVDEADY 643167 643223 43233 saan63 sa3219 42263 NSOACARBIFNIOCREMDALIBTYIEDSESIDGENTETCETSETD DAY 109 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 109 NSAOCRAIBFNIOCREMDALBITYIEDSESDIGENTECTTEESDT DAY 109 NSAOCRAIBFNIOCREMDALBIYTIEDSESDIGENTECTTEESDT DAY 109 `NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 109 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 109 EE Company Sanitized. Doss not contain TSCA CBI 9H0-2.4D5a1y6:GavSaugbcehSrtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANDHAL NUMBER. OBSERVATION OFBISRESTRVDEADY OLBASSTERDVAEYD 43313 NSOACAREINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 107 saste2 NSOACARBIFNIOCREMDALIBTYIEDSESIDGENTETCTEESDT DAY 107 sa3146 SAALCORPIEFCIICAEDBOTBHY DFERSOINGTNPTAWE(SST) DAY 107 sa3m12 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 107 43198 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSEDT DAY 107 543267 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTETSETD DAY 108 -- sa3216 NSOACARBIFNIOCREMDALBIYTIEDSESIDGENTECTTEESDT DAY 108 pee NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 108 3285 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 108 43301 AALLOOPPEECCIIAA LLEEFFTT FFRROONNTT 1P2AGN((SS)) SACRIFICED BY DESIGN TEST DAY 108 643200 NSOACARBIFNIOCREMDALBIYTIEDSESDIGENTECTETSETD DAY 109 643255 NSOACARBIFNIOCREMDALBIYTIEDSESIDGENTETCETSETD DAY 109 43157 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 109 sa3238 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 108 8s 107 88s5 110088 --_-- ompany Sanitized.Doesnotcontain TSCACBI mw H902-4D5a1y6:GavSaugbechSrtoundiycTionxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN Py MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESTRVDEADY OLBASSTERVDEAYD 643227 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 105 sa3164 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCTEESDT DAY 109 sa3154 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 109 43156 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 105 643208 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 109 643190 NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 109 5 EE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 --- INDIVIDUAL CLINICAL OBSERVATIONS IN P, MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY OLBASSETRVDEADY 4328s NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 107 saan TCEOELTOHRECDLIDPIPSECHDARGE RIGHT EYE(S) RED AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) SACRIFICED BY DESIGN TEST DAY 107 sane NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 107 43249 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 107 sane1 TSEAECTRHIFCILCEIDPPEBDY DESIGN TEST DAY 107 43208 `TCEOELTOHRECDLIDPIPSECHDARGE NOSE BLACK - TCEOELTOHREDCRDOIOSKCEHDARGE BOTH EYE(S) RED CSAOCLROIRFEIDCEDDISCBHYARDGEESIGRNIGHTTESTEYED(ASY) 10R8ED 4328s NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 108 sa3z78 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 108 sa3zss NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 108 sa3274 TSEAECTRHIFICCLEIDPPEBDY DESIGN TEST DAY 108 sans2 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 109 43222 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 109 88s5 9o2s 55 110077 8s 8s 98s 10962 95 110086 108 108 8s 8s -_-- Company Sanitized. Doos not contain TSCA CBI ww 5102-6D5a1y6:GavSabgsehrSonoiyeTin oRatcwith One Genero Reproduce Evasios Dopons3%6 - INDIVIDUAL CLINICAL OBSERVATIONS IN , MALE RATS Grove: vio nose: 250 wo/KG/oRY smn woven opservaTION Csionsearnamv woansstmnovnEyD casio wSoACaRIsFwIoCwEmDwrBTYizDsESIpGeNTacTrEESDT DRY 109 cas wSoACrRIsFwIoCwEnDwrBTisDsBSIoGeNraTcErSeR DAY 103 3200 wSoACARImFoICmErDTBiYsDsESIpGeNTecTTEaSD DAY 103 isan: wSoACaRIsFvIoCnEmDwrBTYizDsESIoGeNracTTEeSD DRY 109 coz TSAeCRmIFIcCuEoDrBeY DESIGN TEST DAY 105 cnr wSoACsRIsFvIoCmEmDurBTYizDsESIpGeNmeTcErS DAY 109 cer wSoACrRIeFvIoCmEmDwrBtYisDsESIbGeNeTeESn3 DAY 108 os 2 - --_-- CompanySanitized.Doesnotcontain TSCA CBI w= 1.24516: Subchvonic Toxicty 30-DayGavageSuudyinRats with One Generation ReproductiveEvaluations DuPont-5386. APPENDIX W REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P; FEMALE RATS -- DURING GESTATION - - Tw Sompany Sanitized. Does notcontain TSCACBY 9204:5D1a6y:GaSvuabgherSotnuidcyiToxRiactistywithOne Generation Reproductive Evalusions DuPon5386 - REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN Py FEMALE RATS DURING GESTATION Footnotes EXPLANATORY NOTES a Copulation plug observed but no liter delivered. b Data not collected on day 21 due to error. Nolitter delivered, however, implantation sites observed at necropsy. Notes `This appendix includes only signs from rats with copulation plug observed. Company Sanitized. Doesnotcontain TSCA CBI --- w= H-24516: Subchronic 90-Day Govage Study iTnorRiactistwyithOne-Generation Reproductive Evaluations DuPont5386 _ INDIVIDUAL CLINICAL OBSERVATIONS IN P; FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY OLABSSTERVDEADY 6433522 NO ABNORMALITIES DETECTED 43343 NO ABNORMALITIES DETECTED sa3ass NO ABNORMALITIES DETECTED 6433942 NO ABNORMALITIES DETECTED 643480 NO ABNORMALITIES DETECTED 6433502 NO ABNORMALITIES DETECTED 643363 NO ABNORMALITIES DETECTED 6433970 NO ABNORMALITIES DETECTED 6434216 NO ABNORMALITIES DETECTED 6434202 AALLOOPPEECCIIAA RRIIGGHHTT FFRROONNTT LBAEWG - ASLOOREPERCIIGAHTRISGHHOTULSDHEORULDER 643419 NO ABNORMALITIES DETECTED 6434146 NO ABNORMALITIES DETECTED 43301 NO ABNORMALITIES DETECTED 63455 NO ABNORMALITIES DETECTED 43378 NO ABNORMALITIES DETECTED 6433470 NO ABNORMALITIES DETECTED 43478 NO ABNORMALITIES DETECTED 643386 NO ABNORMALITIES DETECTED 22 2211 22 221 - Company Sanitized. Dossnotcontain TSCA CBI ee 9H0:-24D5a1y6G:avSaugbechSvtoundiyc TinoxRiactistywithOne Generation Reproductive Evaluations Dupont:5386 INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION - GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL WOMBER OBSERVATION OFBISRESTRVDEADY OLBASSTERVDEADY 643399 NO ABNORMALITIES DETECTED 6433365 NO ABNORMALITIES DETECTED 43464> NO ABNORMALITIES DETECTED 643365 NO ABNORMALITIES DETECTED 643490 NO ABNORMALITIES DETECTED 643342 AALLOOPPEECCIIAA BROITGHHTFRFORNOTNTLELGE(GS()S) 643638 NO ABNORMALITIES DETECTED 6434450 NO ABNORMALITIES DETECTED 643616 NO ABNORMALITIES DETECTED 643325 NO ABNORMALITIES DETECTED -- 6436038 NO ABNORMALITIES DETECTED 643376 NO ABNORMALITIES DETECTED 6434220 NO ABNORMALITIES DETECTED 643452 NO ABNORMALITIES DETECTED 63475 NO ABNORMALITIES DETECTED 663372 NO ABNORMALITIES DETECTED 643800 NO ABNORMALITIES DETECTED 6433955 NO ABNORMALITIES DETECTED 6434570 NO ABNORMALITIES DETECTED 1 27 = Company Saritized. Does notcontain TSCA CBI _---- H9-02-4D5a1y6:GavSaugbcehSrtoundiyc TinoxRiacistywith One-Generation Reproductive Evaluations DuPont5386 INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION - GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION BFISRESRTVEDDAY OLBASSETRVDEADY 43320 NO ABNORMALITIES DETECTED 6434882 NO ABNORMALITIES DETECTED 643428 NO ABNORMALITIES DETECTED 643439 NO ABNORMALITIES DETECTED 643353 NO ABNORMALITIES DETECTED 6433852 NO ABNORMALITIES DETECTED 643339b NO ABNORMALITIES DETECTED 6434732 NO ABNORMALITIES DETECTED 643337b STAINED ABDOMEN YELLOW sa3ar6 NO ABNORMALITIES DETECTED 643407> ALOPECIA LEFT FRONT LEG(S) - 6433574 STAINED PERINEUM YELLOW FIEEEH NO ABNORMALITIES DETECTED 43827 NO ABNORMALITIES DETECTED 643433 NO ABNORMALITIES DETECTED 43349 NO ABNORMALITIES DETECTED 6434545 FOUND DEAD 03/20/01 (Test Day 99) 643333 NO ABNORMALITIES DETECTED 643460 AALLOOPPEECCIIAA LBOETFHT FFRROONNTT LLEEGG((SS)) 7 1 2 22 1o 27 _ - Company Sanitized. Dossnotcontain TSCA CBI ow. H-24516: Subchronic Toricity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION GROUP: VITI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY OLBASSETRVDEADY sa3467 AALLOOPPEECCIIAA RLEIFGTHTHISINDDE(QSU)ARTERS oo 22 43843 NO ABNORMALITIES DETECTED 643417 NO ABNORMALITIES DETECTED 643413 NO ABNORMALITIES DETECTED 43338 NO ABNORMALITIES DETECTED sa3ace NO ABNORMALITIES DETECTED 643440 NO ABNORMALITIES DETECTED 6434304 643326 SWETTAINPEEDRINPEEURMINEUM YELLOW NO ABNORMALITIES DETECTED o 0 sa3365 NO ABNORMALITIES DETECTED - 643375 NO ABNORMALITIES DETECTED sa3328 NO ABNORMALITIES DETECTED 6433483 NO ABNORMALITIES DETECTED 43336 ACCIDENTALLY KILLED 03/12/01 (Test Day 91) 1 1 643839 NO ABNORMALITIES DETECTED 643429 AALLOOPPEECCIIAA RBOITGHHTREFARRONLTEGL(ESG)(S) `ATLEOEPTEHCICALIRPIPGEHDT FRONT PAW(S) DWEITARURNHDEEARBODY. SWETAAKI.NED PACE BROWN 0 21 2o 2o 22 22 22 22 6434248 NO ABNORMALITIES DETECTED ~~ `Company Sanitized. Doesnotcontain TSCA CBI wm -- 9H0--24D5a1y6G:aSvuabgcehrSotnudiycTionxRiactistywith One-Generaton Reproductive Evaluations DuPont 5386 APPENDIX X REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS - DURING LACTATION = --- Company Sanitized. Donotecontsain TSCA CBI w= 012-4D5a1y6:GavSaugbesSotnuidcy iTnoxRiactistyvith One Generstion Reproductive ralutions -- REPRODUCTIVE TOXICOLOGY Dupont 386 INDIVIDUAL CLINICAL OBSERVATIONS IN P; FEMALE RATS DURING LACTATION Footnotes EXPLANATORY NOTES a No copulation plug was observed, however,a litter was delivered. b Found dead prior to collection ofDay 0 lactation clinical signs. Note "This appendix includes clinical observations from lactating rats only. - Company Sanitized. Doss not contain TSCA CBI _ 9H0-2-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING LACTATION GROUP: I1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY OLBASSTERVDEAYD 643343 NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DRY 122 sa3ase SNAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 120 643380 NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 122 san6a NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 122 643397 NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 120 sa3a21 NSAOCARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 120 ~ sa3419 NSAOCARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 122 6a3301 NSAOCARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 121 sa3ass NSAOCARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DRY 122 643378 NSAOCARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 125 43447 NSAOCARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 120 43478 NSAOCARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 122 643386 SAALCORPIEFCIICAEDLEBFYT FDREOSNITGNPTAHE(SST) DAY 126 2 2 CompanySenitized.Dossnotcontain TSCA CBI -- = H-24516:Subehronic Toxicity 90-Day Gavage Study in Ras withOneGeneration Reproductive Evaluations DuPont-5386 _ INDIVIDUAL CLINICAL OBSERVATIONS IN P; FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESTRVDEADY LOABSSTERVDEADY 643399 SNOACARBIFNIOCREMDALIBTYIEDSESIDGENTETCETSETD DAY 132 43330 NSOACARBIFNIOCREMDALBITYIEDSESIDGENTETCETSETD DAY 120 sa3a6a DSIASCCRHIAFRIGCEEDVABYGINDAELSIGONPETNEISNTG DRAEYD 121 643369 SALAOCPREICFIIACEDBOBTYH DFERSOINGTNBTAWE(SST) DAY 119 64340 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 119 43342 ASLAOCPREICFIIACEBDOTBHY DFERSOINGTNLETGE(SST) DAY 123 -- sa3438 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 121 preven NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTETCETSETD DAY 125 sa3s2s NSOACARBINFOIRCMEADLIBYTIEDSESIDGENTETCETSETD DAY 123 6434792 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 120 643376 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 120 sa3s52 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETESDT DAY 120 643475 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 120 ca3a72 ASLAOCPREICFIICAEDBOTBHY DFERSOINGTNPTAEWSST) DAY 122 7 2 2 7 2 `Company Saniized. Doesnotcontain TSCA CBI mm -- 9H0-2-4D5a1y6:GavSaugbeehSvtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py FENALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY LOABSSTERDVAEYD 643400 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 121 643395 NSOACARBIFNIOCREMDALIBTYIEDSESDIGENTETCETSETD DAY 120 sa3as7 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 120 ~-- Company Senitized. Doos not contain TSCA CBI mm -- 9H-02-4D5a1y6G:avSaugbcehSrtoundiyciTnonRiacsitywith One-GenerationReproductiveEvaluations DuPoni-$386 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY OLBASSETRVDEADY 43320 NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 122 sa3428 NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 122 sa3a39 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 122 43353 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 120 643339 SNOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 120 643237 SNOACARBIFNIOCREMDALIBTYIEDSESDIEGTNECTTEESDT DAY 120 --- 43416 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 122 643807 ASLAOCPREICFIICAEDBOBTYH DFERSOINGTNLTEGE(SST) DAY 120 643331 ACBONLOORRMEADLDGIASICTHAROGREMONBOISLEITBYROWN HDIUSNCCHHAERDGEOVVEARGINAL OPENING RED SACRIFICED BY DESIGN TEST DAY 120 sa3427 NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 122 sa3a3a NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 122 sa3349 ASLAOCPREICFIICAEDBOTBHY DFERSOINGTNPATWE(SST) DAY 121 643333 ASLAOCPREICFIICAEDRIGBHYTDEFSRIOGNNT TPEAWS(TS)DAY 120 643460 ASLAOCPREICFIICAEDBOBTYH DFERSOINGTNLTEGE(SST) DAY 120 2 oo o7 o 1 2 21 2 2 -- Company Sanitized. Does not contain TSCA CBI -- w= H-26516: SubelronicToxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont5386 INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY OLBASSTERDVAEYD 643467 NSAOCARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 125 643443 NSAOCARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 119 64317 ATLEOEPTEHCICALIRPIPEGDHT FRONT LEG(S) SALAOCPREICFIIACEDLEBFYT DFERSOINGTPNATHES(5T) DAY 115 43413 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 122 sa3a38 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 122 _ 6433350 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 121 sa3ass NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 125 43440 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 122 643326 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 122 643365 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 122 643375 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 121 sa3328 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 121 prev NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 125 643420 FOUND DEAD TEST DAY 106 17 22 2 2 o ---- Company Sanitized. Does not contain TSCA CBI ww 9204-5D1a6y:GavSaugbcehSvtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPon5386 APPENDIX Y INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Py FEMALE RATS EE Company Sanitized. Doos notcontain TSCA CBI 9H0.2.4D5a1y6:GavSaugbcehSvtoundiyciTnoxRiactistywith One Generation Reproductive Evaluations DuPont 5386 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS - DURING PREINMPA,TFIENMGAALNEDRCAOTHSABITATION EXPLANATORY NOTES Footnotes: a Mean cycle length was not calculable due to insufficient data. 5 No evidenceofcopulation was found; animal was not pregnant. No precoital interval could be calculated since no evidenceofcopulation was found. d No evidenceofcopulatiwaosn found, but animal was pregnant. Data were excluded from statistical analysis since the animal was pregnant during part ofthe estrous cycle evaluation. Abbreviations: -- = NoData - Company Sanitized. Does not contain TSCA CBI = -_-- 9102-5D1ay6:GavSaugbeelSvoundiyc TinoxRitcistywith One Generation Reproductive Evaluations Dupont5386 INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYRCRLBEITPAATRIAOMNETERS GROUP 11-01 0 MG/KG/DAY E mrs or or E or or cre smscorm IAMmSeElR COLDLEACATION DEASNTSRUISN _DDAIYSSSTAIUNS PDROABSSTRIUNS L(EdNayGsT)H IN(dEaRyVs)AL ssanirediren 2i 22i 5aa n7o oaaswke 224 6sG333i5se00 p31l a2i 5i7 i6TooNuWsnwe n3e sasansiisase iFie iiFso i77 2wYoosoanns 3i Gssaiansaisensss i2 iion ii5 w3o va amkks2 Gaaaannne FH73 52i 5a& n FpEO osoiem Ji2e SSGiaritazenere p25y Ei5H si5e nB5 oasnShn 331 - Ssiasaiz 5zs 5a a5 5 Bos um win = EE CompanySanitized. Docs notcontainTSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaion Reproductive Evaluations DuPont-5386 INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIROMNETERS GROUP TV-0: 25 MG/KG/DAY WOWSER OF oats or PERoCFENT PoERrCENT PERoCFENT cWuEeNs eRecormaL ANUNMBIELR COLDLAETCTAION DEASYTSRUISN DAYS IN DAYS IN LENGTH _DIESTRUS PROBSTRUS (days) INTERVAL (days) psaenarzs 226 2n6 07 2` i so 7s sar3eeir38 22 pre 26 n8w 2 n 56 n1o a21l3o3 33 i do 5 G88i44333a34s69a30 FH22 25 7so Bn 7s ss sloloo 1i 5 io 2 E8443333935 23 843457 23 221 02 7 F5O loo i2 ` ilo 2 sa3343090s pres 25 2 beF}d 2 a70 a ooo sallooo 23 3 aloo 3 SSa4z3as72 Gaaazs 22a 2 1257 s&s 25 50 0Bde der FH] 3ls0 113 - 4G433347063 32 preveet 5 o2s 57" 23S aialsnno l31e EL `Company Saniized. Does not contain TSCA CBI -- H9-02-4D5a1y6G:avSaugbcehSrtonuidcy iTnoxRiactistywithOne Generation Reproductive Evaluations DuPont-5386 INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIAOMNETERS GROUP VI-0: 100 MG/KG/DAY WoMaGtEsRopOF PERoCFENT PoERrCENT PERCENT OF MEAN crc pRECOITAL ama MMBER DATA COLLECTION DAYS IN ESTRUS DAYS IN DIESTRUS DAYS IN PROBSTRUS LANGTH (days) INTERVAL (days) 8a4a330367 803473 22235s 2220 a2 & pr"] s5l.0000 i 23. 5G0a3l3e3s9 Sa335 32 22 7& 2 FH ss 05 0 isios der 211 &84433443298 Si3as8 22255 ES 2 500 0 0 saleoro 4i 2 as h prGio3v3e2s0 43333 22s fr2} 2 2 ass 1228 a3iss i1 Bam 1 Ssaaa33s3aaass9ae b223y 2265 20 a& 7 nBo alsdoo 32 5 300 i prsaazi3ae4z7d708 25 2 5o1 5 n5 " 2o m 6.00 L.3 Wo soo 1 --- Gparriae0d7 =2 3502 &5 u3w dsoloo 12 ~ Company Sanitized. Dossnotcontain TSCA CBI nT H9-02-4D5a1y6:GavSaugbcehSrtoundiyciTonxRiactistwyithOneGenerationReproductiveEvaluations DuPont:5386 INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIROWNETERS GROUP VITI-0: 250 MG/KG/DAY aoa NMBER WbOWaBsERoOrF PERoCFENT PERoCFENT PERoCFENT cMyEcAiNs pRECOITAL DATA COLLECTION DAYS IN ESTRUS DAYS IN DIESTRUS DAYS IN PROBSTRUS LENGTH (days) INTERVAL (days) psSraae3ze4at3ny0d 32s 2 21 eo 17 u PaETmRI 3 5750 i pr43i3n35 Gass 32 2 n7 a7 2& 5os &sowo ol5e Bo as Y GGii3a0i1a7 Si3443 22s 2 25 52 55 B5s do0o0 :1 is 508 1 sGii33ie2647 si3420 22 27 7 26 10 & 25 ahe 3 `1 a a0 8 GSea23434456 8i3348 22 2i6 &2 2 25 7n 47s 3lo6o ilo 72 i Gi8830433333672s58 32 2 I1g 27 25 0n 5s1l0303 23 7 slo i . pe 2 2 & 12 aloo i - CompanySanitized.Doesnotcontain TSCA CBI TE 910.2-4D5a1y6:GavSaugbcehSrtourdiyc TinoxRiactistywithOne Generation Reproductive Evaluations DuPont-5386 APPENDIX Z INDIVIDUAL ANIMACLOHEASBTIRTOAUTSICOYNCILNEP;STFAEGMEASLEDURRAITNSG PREMATING AND -- _-- Comp`apnayny Saniized. Doesnotcontain Tsca ops ww 1902-5D1a6y:GoSvubeetSrotniyeiTnoxRiactistywith OneGeneration Reproductive Eralustions DuPon-5386 - INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND `COHABITATION IN P; FEMALE RATS EXPLANATORY NOTES Notes: `Test Days 54-75 = Premating `Test Days 75-88 = Cohabitation period Abbreviations: D = Diestus EP== EPsrtorsusstus X = No sample or stage could not be defined from sample. Footnotes: a No evidenceofcopulation was found; animal was not pregnant. bNo evidenceofcopulation was found; animal was pregnant. = --_-- Sompany Saniized. Doss not contain TSCA Car ww ~ i5 8 : EHR HHHHH i fE e H l He RH 5 Eso || E Er Rr E IR 3& E | E E Eree TCEel 33 8fF | E EO E E TTemTT g2 sg || EEaCleEs ara ealmaleleaR l|alaalaRre]l | [lal5e- EsElEa NEooN-OE0EEEEE-TNED S E5 |E[mFomle e c a ooalll BBaa oo Elo)! [[RE ERHlEennn0. oaEE8a-.0E<E6E.E8E-R0E8- B8E [aces EEE 668-68. - f g f a oo9|| EC llmecE lselolae lomaREou mel dF| Emap ecclem once IE = Cees sme, [I BREE &- -DEAREERERE EE | Splat d iz : | [BEElRElEEE-eEcElRo-l8s-clel0-58: - B5)f a EgiE2 l : [[22515f]eReBTEEncclo Bl[ooolPeEoo~l J ola He o =| || 24) 54 - z ] | | i -3 3| z E E ER g eT Te E Te : 5 || E E E e C r CE e 3:i P| ||EE ELMESe re e :i 3 35 ||[EFleepeemEBdar HleaT EelRET ee) 3 ii;|| FEEE8mEeCESH S REceeacRm cR a mooogclooe) 5io28|E[[EaeemlmEkMoaR]clclloolloooMoEolcElalEaolall~ol~oolTa0)) -J : Fo: % |[f FioEEeEgCegeEEce-NemabEscloololeoloail]eIel) "2 L24I R Sf||e[EREeoemcoaoslMeesgaecEelEkaBaooEg RoBEeE 1bgf f||| EEERoEcSRhbEokMcskegeeeNeslgeSlEEdeeoolCoele q|| d; ||| CC ECaMkEecR geE mE-loS Eeclo m Ee UigEFf || cEEoEeoEooEegccEmccemmeem:oBom-eecMol6m8g-EoeOlma]eE 2I3 | EFeafEcllocllollolisilaelcooioBllloagoMoolomoe]lo | H3H2 ERI E 1 | = #2 | ~ 3os! 3 a - 2 | HH 3 5 4 2 3 & 2 iEH 2 2 _ i4 Te I TT T FE Rg Fs HH fe grr 3 Eg rrr E (eg rrr i] Eg rr g ER Hi Eee 3 | Eee mel 4 i| pcleomeme- cl i : HENENENEEEENE5 N - HEE] i [Elelalc@ [alalIaaalallafg|al g H-BRRE - - 8 =BE SHEE] gz | Elelma-Esllalo aefa ala] e 3 [a2] [cE lcac fac fea Eaala) 2 2 [EERalc@alalaialo fe lolo GEN g [[F@alalalalap [cRCBl Ea PEERHEEE 08- 8-08-5858 Bi g = "zai flelslo alas aloo] FEFREA-E 8 BEE- 5 BE a5] 2 7 | EReRBEREkaEa ema] CEE -RRERE- 2 BREE- - BEE- BEB 2 & | zlaafglaleanaaaaaaalgamols| CEAEEE E [=[a]a) 2 [lafalalxalala) BEB JE = 2 [glajalalalo@ala falcEa(a flalalala] EB Eel Emc Rage ka alsa lamas] a HEEREER-- BARE- A:- A8E- 5) 2 [zeal @ccE@ cla a lc al 8 [Ee@sla@alala] [=lalaf= a] zlalalcfa EacE Elan ala g [FEsEa] Jala]a ~~ENE ~[a] = Elolslalaalalalala@alsla lalla ap a] Hannan ake El B33) 5|3(3(3[3|3)3) 2|E|[33353] 8 g3 5gs 3 5 8 3 3 5 2 f | | les = ~ o3f a EH El Te TT TITTTITTT ERs rrr [2] He HHH HHH ela Ta 5 [Ee Terr g [Ela eT FH] [lal e a 2 [fal Tal TT fala TTT g [lel maT alTTT] [Ea ala al fala TTTTT] z 2 HN AEEENNEN- - RENE 8 _[a[a[a[a[laaClEE [al lala) g [Ela][aja[affala[allaal=[la[Hllalal FREER- BRE-- - AREEE BE - g | Elgal [c[a[a[a[a[c@=alalalalala] o | [E@elelalaklalalala] [s@alsla) 2 |EERaallalaalalaaEialaalalalalalal g - |.Ee@alale] BE -22lo) a & [EE[llala] 5 [o@a@alolo) - g [lajalalalalalalalalalalala Ea galala) iz HaEbE|EHCl-opAeEleElRoRRREa EEoE-oloBlEaiE- BEE,Ee 3 FEEEEAE- EB= 0- BE = 8 - BEE- - B) 2{g8fo|| E[gElaelaElaElaR<ElaEa[Ealaafc@alaalloaafeelaa la] 2 g [g]alalalala BREEE BE 8 HE- AREER [2@a alala] 53 BEE -AREER-- HEEE- 6) 2 E [glaalalalalalalalalalalalalalalalalalal | i H-BARE- - [a[ala/a fala] 92 Elo@alce@alalalcfom@alalalalalal |8 BE BRREREEE - BE- 3 = BE) 3& [Ea goclc@alc@alnlaf@alalal 23 g [Fala oo EE -[~IEo ~~ [E 2 = [ERaEe~E- Ee Elaalaa ga) 3 Z2<Z3% ~ 34 [ERE EERE RRR EE |2z[z[zfzzlzelcz5)e3 3 01 0 | 3 3]s 83 2 g H 3 g 3 3 3 8 lee = | | | | || | 9H-02D4a51y6G:avSaugbcehrSotnuidcy iTnoxRiactistywith One-Generaion Reproductive Evaluations DuPont 5386 APPENDIX AA REPRODUCTIVE TOXICOLOGY INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN P; MALE RATS --_-- Company Sanitized, Doss not contain TSCA CBI 91.02-4D5a1y6:GaSvuabgcehrSotnudiyc iTnoxRiactistywith One Generation Reproductive Evaluations Dupont5386 INDIVIDUAL ANIMAL SPERM MOTILITY DATA INP, WALE RATS oGwroku/p o1R-0e MBouibseer pheoxtcielnet asaanirzeo3s0 555 GGaitaazzeezeo 555% aGaanan2n0ee7 a55 Gaze 5 2a5 Woo/R1G11A-Y0 Siupbear pMeortceinlt Gs6ia4rr3t22o03n70 s22s% GaGGsaas1nt4rnao 325 GGiearertetes a55 ans 5 10r0 oWvGe/KGv/-D0AY 25c0ovNeG/XvBi/z-ooRY TAininmbearl p_e_hrocteilnet aSnuibmearl pMeortcielnet cGGaaarsrtieenne 5556 sSfioorri2s0ne9 a&5 - fcaaitss 5a GParEzaE 35 EGGa2ar2n26te7ss s55s sGaaGr32zzte7ss 2a5 GGar32e0s 52 6a32n09 a5 --- Company Sanitized. Does notcontain TSCACBI ww 9102-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX BB INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P MALE RATS ~ -_-- Tw `Company Sanitized. Doos not contain TSCA CBI 9H0--24D5a1y6G:avSaugbcehSrtoundiyc iTnoxRiaciistywithOneGeneration Reproductive Evaluations DuPont 5386 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P, MALE RATS GROUP 1-0: MG/KG/DAY ANniimebaelr sap3e2e39 psr8a6ez32c282y89 G0e3i1s7s6 s8i633221087 si3280 TNootmaall AbnToarilmal AbnHoeramdal TaAlblno&rmHaelad PeNrocmeanlt 210909 1 o fe s oo 190.0.50 975 11957 1 o5 198 2 o 559s5 3500 119915776 23 23 2 588''ss 5800 1% 2 970 GROUP III-0: 25 MG/KG/DAY ANniimmbaelr NToortmaall AbnToarimlal AbnHoeramdal TaAiblno&rmHaelad pNeorrcmeanlt - sasiss2i0s7s 191599 o 11 sa3230 198 2 00 955.85 350 ssuasznerso 115585 21 0 59's pr4e3a277 151525 12 5o saz261 200 o 90s0 0 100.0 Gaanness 1is9s7 1 22 589s0 CompanySanitized, DoesnotcontainTSCA CBI -_-- ww 9F0--24D5a1y6G:avSaugbcehrSotnuidcyTionxiRcaittsywithOneGeneration Reproductive Evaluations DuPont 5386 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P, MALE RATS GROUP V-0: 100 MG/KG/DAY ANniimmbaelr ssiuaanss2 GGaitaensz 880433216979 siG3a3221061 Gp4e32t45 NToorrmaall AbnToarimlal AbnHoeramdal TaAiblno&rmHaelad PNeorrcmeanlt 11955 o1 is 198 i 1 0 957%.05 0 3970 201155909 11 0 19302.01.580 11909 1 11 158 3 1 F39e7d0 3970 159 1 595 GROUP VIT-0: 250 MG/KG/DAY aNaoismbaelr NToortmaall AmToarilal AbHteoardeal TalAlbno&rsHaelad PeNrorceeanlt - p54r3e2a89 191563 52 2i Gannse 199 1 o S58s.0 S58 prGraee3re2e49 220019007 5 ooo 11500800..s00 psrasae6s 113578 o 23 G43295 200 o oo 5S.550 0 105.0 Sa3274 is 5 o 58.5 -- `Company Sanitized. Doesnotcontain TSCA CBI wm -- 5102:4D5a1y6;vaSugbeSotnuidcy iTnoRiaisywithOne Genertion Reprodacive Evalsions Duron APPENDIX CC INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN P, MALE RATS - --_-- Company Sanitized. DoesnotcontainTSCA CBI wm H-24516: SubchronicTonicity 90-Day Gavage Study in Rais with OneGeneration Reproductive Evaluations DuPont:5386 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN P, MALE RATS GROUP I-0: 0 MG/KG/DAY AnNainnbaelr ssuiazse sSuiemss sGiutzees ssSuuu2a0esr Sue PrEpciaduiddaymalFesrpermcaus a20i9o3 1120156770.8 22554690 25588.16 aanieo 115040074.4 33222ml00s 1f6r15i9.t5i15d 2666 582 PTeersttiecsutliasr spermaPtoirds5 testis 110298.09 6a.l0s mlrles 9f0z0 reilvesd oBv64o 10e3esn 0s0a's 11s8'73 #81s GROUP IIT-0: 25 MG/KG/DAY ANniinmbaelr PerSpcaasidaayma)PesrpgermCauda PTeersttiecsutliasr spermaSteirds5 cootie Gcaotzeesr 222901m u85s0a5 1262.0 5s4.s8 - sGGai1ms0o 2323420600s60 1m500465s1.71 11386.078 10700 27508 Jey GGis2217a 22a0s0l0e6 8e5r6e3 size 2303 3955 s17a2l0e8 1245 n79o7s5 8612 sRiEteTs 3379 2Se88..a0 1ni0l6e i5l5i EE `ompany Sanitized. Does notcontain TSCA CBI 9H-02-4D5a1y6G:avSaugbcehSrtonuidcy iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN P, MALE RATS GROUP V-0: 100 MG/KG/DAY Afnimeal a sdiayna) spea rm Testicua lar spermactoisdtsis sGamtne 2290.083 1i23s5e.5 115508.033 sone 30s 57010 166.0 110061.03 1031 Gsnsas 2206010s8 78723366 Gazer ams priv 11688.003 1585 9a8210 sis GGGiaa3zm2aeesa a2a8m7900 68551400.0225 11666263'.7s6 111000862.363 Gar mz nse 16575 120s GROUP VIT-0: 250 MG/KG/DAY ATnotneealr TEiRdiaymalFesrpgernau FTeersttiecsutliasr spermaPtiedrss sSciaonsiemsse 332622810.3s3 1a825s84a0.l.7s8 11034'.s4 13309 5s76i9.l11o1 - GGaaztee aazms 191767..77 1216210312 Ssaes 2043 506.5 15403 1a01s8 Frey SGiinaaers 231s00 8z97es 116669.50 1807.38 GGaasnees asmiise 88559536 1is4i206 0501037 Sompany Sanitized.Doesnot contain TSCA CBI 3 H9-02-4D5a1y6:GaSvugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX DD REPRODUCTIVE TOXICOLOGY -- INDIVIDUAL MATING DATA AND GESTATION LENGTH: P, GENERATION Sompany Sanitized. Doesnotcontain TSCA CBI -_-- ww 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc TinoxRiactistywithOne.Generation Reproductive Evaluations Dupont5386 ~ REPRODUCTIVE TOXICOLOGY INDIVIDUAL MATING DATA AND GESTATION LENGTH: P, GENERATION EXPLANATORY NOTES Notes: Column labeled "Plug Observed" + indicates thata copulatory plug was observed - indicates that no copulatory plug was observed Column labeled "Litter Produced" + indicates thata litter was produced indicates that no litter was produced Footnotes: a No litter delivered, however, implantation sites were observed at necropsy. No copulation plugwas observed, however,a litter was delivered. Gestation length = unknown. Found dead on Day 2G (Test Day 99). d Accidentally killed on Day 14G (Test Day 91) Found dead on Lactation Day0 (Test Day 106). - --- Company Sanitized. Doesnotcontain TSCA CBI w= 0H2-4D5a1y6:GavSaugbechSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evahations DuPons-5386 --- INDIVIDUAL MATING DATA AND GESTATION LENGTH: Py GENERATION GROUPS: 11-0,1-0 DOSE: 0 MG/KG/DAY AFNEIMMAALLES GGi33423 33340589 sGais3ssieo0 GGan3d3e9s7 sGi3naazz0 GGaelsa Gsi03i1ss S83337983 sia3r4e7 suse MAANLSI1L ecaaszaazrso ccaarrzdess escaaannsn2nzees e64a3t20s7 eearazem0 ecaarines ccaanrasstz ccaarneeys eeaa3rznreer eaazse OBSPELRUVGED :. :: ::: :: :: :: :. :: :+ : AMNAIEMALWSZ OBSPEORGVED PLRIOTDTUECRED ::2 ::: +::: :: .: :: :. : LGoENSoTTAHT(IdOaNys) 2-3> n2= 2222 F=r 2= 22 F>y 22FA -~ - Company Sanitized. Does notcontainTSCA CBI ww 01.-2D4a51y6:GaSvuabgcehiSotnuidcy TinoxRitcistywithOne-Generation Reproductive Evalusions DuPont5386 - INDIVIDUAL MATING DATA AND GESTATION LENGTH: Fy GENERATION GROUPS: 1v-0,111-0 DOSE: 25 MG/KG/DAY eDmAesLisY cGGuaneisas GGaeisso GGGoiodzss ffasis GGEoaoanraseb Gizse GGaaumss aGGaassos AwNaIMsALnS eccaaasnaenss ecaanma eenaam eeaasee eaeinansns csaroiems eeearm nesaairsen ie OMwERoVED NWMMDEALSS2 OBSFEIRGVED PRLOIDTUTCEERD LEGNEGSTTHA(TdIaOyNs) :.: :.: 3=FH] ::: ::: i3pH ::: ::: 22z ::: :S i= : = ::: :: =zn : = ::: ::: 3522 :: :: 32 = -_-- Company Sanitized. Donote contsain TSCA CBI ww 9H-02-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL MATING DATA AND GESTATION LENGTH: P, GENERATION GROUPS: VI-0,V-0 DOSE: 100 MG/KG/DAY FAENMIAMLAELS sGanme SS33ia5na3zs SG3e3s5 G63a3m3s7 sGiis0a7s SG3333s17 GSGa3iu7a0 GGie3a3i4s5ac GGia3is30 WANEIMAL#S1 cearatenz ce6aaxrnn9ld0zs ccaarraneer ecaarrnaeeds ccaarrssoonn ecaannassys escaaraiaests ccaannss seaamdseo OBPSLEURGVED .: ::: :: :: ::: :: .: :: :: MANMIEMAL OBSPELRUVGED RLOIDTUTCEERD .: ::: ::: ::: :: :3: 2: :: LGENEGSTTHAT(IdOaNys) 2z 222 2>= 223 n= 2-2 3jo 2= Company SaniDotesznotecodnta.in TSCA CBI TST H24516: Subchronic 50-Day Gavage Study TinoxRiactistywithOne-Generation Reproductive Evaluations DuPon-5386 - INDIVIDUAL MATING DATA AND GESTATION LENGTH: P: GENERATION GROUPS: VIII-OVII-0 DOSE: 250 MG/KG/DAY AeNmGsLE GGoaaesr GG3437 GGa3s8h iGGii3ss3aiie00s GG302 GG33a3e7zs5 GGGiiidaianesd sGeasuizise WMNAISMA9L1 ecaaanzems ceaaznzsaes ccaarneen eccaaasssaeaess ceaarnessz cecaaarnnaez;oz 6c4a2s2s0e0s aczaaas0rz cae OBSPELRUVGED :. :: :: ::: :: ::: .: ::: WAMNIEWAL#Y2 OBSPEURGVED PRLOIDTUTCEERD .. :. .: 2:: :: :. ::: ::: LEGNEGSTTHA(TdIaOyNs) 2F F=Y 2= 23 2= 33 5=bo 23= EE `Company Sanltized. Dossnotcontain TSCA C1 9H0.2-4D5a1y6:GavSaugbeehSrtoundiyc iTnoxRiactistywith OneGeneration Reproductive Evaluations DuPont $386 APPENDIX EE REPRODUCTIVE TOXICOLOGY INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY = Company" Sanitized. Does notcontainTscA cay 1 9H-02-4D5a1y6:GavSaugbechSrtoundcy iTnoxRiatcslywithOne-Generation Reproductive Evaluations DuPont-5385 - REPRODUCTIVE TOXICOLOGY INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY EXPLANATORY NOTES Footnotes: a No implantation efficiency can be calculated. 5 Nolitter produced; no implantation efficiency calculated. 4 dead Day 22G (Test Day 99); the uterus contained 17 fetuses. ally killed Day 14G (Test Day 91); the uterus contained 12 fetuses. e rounadead Lactation Da0y (Test Day 106). Abbreviations: -- = Noda `Company Sanitized. Does not contain TSCA CBI --_-- wm 9H02-4D5a1y6:GavSaugbeehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: II-0 DOSE: O MG/KG/DAY AHnuimmbaelr BPourpns. ImSpulrabnetratoifon ImEpelfainciteantciyon sites sa33a3 12 10 ea sa3ass 15 16 93.8 sa3480 15 15 100.0 643363 1 18 94.4 6s4a333a9271 1126 1 13 54.1 92.3 ca3419 16 15 Sa sa3a1ab o 2 ee 43401 15 16 3.8 sazass 16 15 100.0 643378 8 s 100.0 43447 15 19 100.0 643478 15 15 100.0 43386 15 16 03.8 = Company Sanitizod. Does not contain TSCACBU EL -- H-24516: SubchronicToxicity 90-DayGavageStudyinRats withOneGeneration ReproductiveEvaluations DuPont:5386 - INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION BFPICIENCY GROUPS: 1V-0 DOSE: 25 MG/KG/DAY ANnuinmbaelr sPourpns InNpulrabnetratoifon IEnfpfliacniteantciyon sites 643399 1 1 82.4 643334 15 16 93.8 sa3a64 1 10 643369 18 1 1l00a.0 643450 1 4 100.0 43342 16 16 100.0 ca3azs 1 IY 82.4 sa3a10 15 15 100.0 643325 15 16 92.8 643479 2 5 77.8 643376 15 sa3a22b o 162 9p3o.8 sa3as2 12 1 80.0 643475 2 4 50.0 43372 17 18 94.4 643400 15 15 100.0 643395 5 5 100.0 - 643457 16 16 100.0 -- --- `CompanySanitized.DoosnotcontainTSCA CBI hs H90-.2D4a5y16G:avSaugbcehSrtoundiyc TinoRxaictistwyithOneGeneration Reproductive Evaluations DuPont:5386 - INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION BEPICIENCY GROUPS: VI-0 DOSE: 100 MG/KG/DAY HAunribmearl BPourpns ImNpulmabnetratoifon IEmeptliacntiaetnicoyn sites 643320 Bg sa3a28 1 15 16 0.0 07.5 43439 1 643353 s 15 1n 97.5 sis 643339 62237 15 15 16 1 93.8 8.2 43426 5 643407 15 8 1 75.0 ea 64321 s 643427 1 12 15 75.0 93.3 643430 43349 16 1 4 18 a 200.0 sa3a54C ee 43333 2 1 5 77.8 643460 rl 1 100.0 "ompany Sanitized. Doos notcontainTSCA CBI TST H9-02-4D5s1y6:GaSvuabgeelrSotnuidcyiTnoRniactistwyithOneGeneration Reproduciv Evalustions DuPont-5386 - INDIVIDUAL THPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VIIT-0 DOSE: 250 MO/KG/DAY ANnuimmbaelr BPuoprsn. IaNpulnabnetratoifon Sites InEpflfainctiaetnicoyn 643467 643843 5 12 12 1 pe a 643417 43613 10 12 13 12 76.9 100.0 643338 643335 1 1 16 16 7o.r5s s6a433a4c4s0 4 10 18 18 7.8 100.0 643326 63365 1 5 16 s 7.5 a 643375 643328 5 u 1 12 earned just 2 3951..77 jo. 643449 sa3azse 1 16 1 it 1a 00.0 - `ompanySanitized. DoesnotcontainTSCACBt TT 9F0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One. Generation Reproductive Evaluations DuPont$386 APPENDIX FF REPRODUCTIVE TOXICOLOGY _ INDIVIDUAL PUP SURVIVAL: Fy GENERATION = ompanySanitized. Does not contain TSCA CBI eeeepesee 5 ---- S---- ----r -- e-- e 9H-02.4D5a1y6G:aSvuabgeehSotnuidcy iTnoxRiactistywith One-Genersion Reproductive Evaluations - REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP SURVIVAL: Fi GENERATION EXPLANATORY NOTES DuPont5386 Footnotes a Nolittr delivered. b AFcocuinddendteaaldlyteksitlldeadyte9s9t (Day 22G). day 91 (Day 14G); no litter was delivered. d Found dead test day 106 (Lactation Day 0); data excluded from statistical analysis. Number bon includes 13 unsexable fetuses. - Sompany Sanltzed. Does not contain TSCA CBI Tie 9F-02:4D5a1y6G:avSaugbeehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evalustions DuPont-5386 ~ INDIVIDUAL PUP SURVIVAL: Fy GENERATION F-- E ----G-- ROUP: T1-- -0 D-- OSE: 0 -- MG/KG/DA-- Y ---- waGER OF PUPS apm Bom ABLOIRVNE BREDCAUYLL4ING PODSATLCUL4LING DAY? DAY DAY 31 TovsER paar3e3as20 12Sizass 1s 12. 5 12. is Si330aa p - . 5. :` 8.: a.: 55: GSae3nisi0e 1sGeazson - 5- 1- 1" 1" wv s.- 5a- 5a- - 5: pSSraaez3a3z917 126 1162 112 Gi34200 - - : s5 : 5|: 88: 5s: GiG3ia31aa9a 1: Si3a01 1s 6: 1 51: Sasass i is 5 ?a 55 : .8 .: s5 s 85 4i33379030 5GGea334a778 11 - 5- 1is i1s so :e 55 :` 55 :: 5` G43386 is i 1 s 5 5 8 - Company Sanitized. Doesnotcontain TSCA CBI oTI6r T ---- 9H-02.4D5a1y6G:avSaugbeckSotnuidcy TinoxRiactistywith One-Generaion Reproductive Evaluations DuPont-5386 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: 11-0 DOSE: 0 MG/KG/DAY aSomweEnn Bmw Sseianasean -5 Sia333a0sa90 12: pprreeyd 5GSaiazzesson 7: G4r33e97 55 GGeeeazr0s0 n: pGreenrneeys 122 8S4a33a7s0 10s Gea3aa4s7an 12: S4u3n4e7s0 05 MBER OF MALE PUPS ABLOIRVNE PRECDUALYLI4NG PODSATYCUL4LING DAY - - i- :5 2: 2p 5: 5: 5: s: a- i: .2 5: h3 +-i s 6$ 3: i: un3 n> 1 12 `: 5 `: 5 s5: 55: 5a: 5:: 1102s 112o ii 5 i3 3 DAY 14 DAY 21 :- n- :: 5: `- 4: `- -a ii: ai: a! i: 5: 3s s: 5: 5 +H ` i ~~ CompanySantized.Dossnotcontain TSCA CBI Te 9H0--24D5a1y6G:avSaubgcehSrtoundiyc iTnoxRiactistwyith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: 11-0 DOSE: 0 MG/KG/DAY oANuIsMEARL Bo p84r43e33v35i42]30 &-5 44338389000 5Gaannissoen -prG4e3e3r9t7 105 GGeiuazne :` SSSiei3aiaz011se 35: 4Ge3a3s7s 35 Gee3aa4s7ae 7: S54i3n4e7s8 s7 MMBER OF FEMALE PUPS ABLOIRVNE SRECDUALYLI4NG PODSATYCULLING DAYT s5 3-` 5- 5- -: -: 05 0 5: 5: 5: 5: 53 s5 52 5: 72 2a 5 s 3- i- 3- -3 z- psi: i` i 3i3 a3: a:3 33 33 33 5: ii ii 3 i DAY 4 DAY 21 3- i- -5 -3 :-` -- `` 5 aaa `!i i:: a3 i3 53 3: 3: ii i 3 CompanySanitized. Doss not contain TSCA CBI -- ie -- H-24516: Subchronic 90-Day Gavage Study iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: T1-0 DOSE: 0 MG/KG/DAY ANoMwBER 5a4a3z3s4z3a GGae33a3505aa SGeea3nai8s0e 5504333365300 4e3334817 SSai33aa12900 pSr38e0 asnaa3s7s0 GZai333a973a SSa3334e80 NowsER OF PUPS SEX RATIO (WAISS) % BORN ALIVE 0-4 DAY VIABILITY 0.- 50 100.-0 100.-0 00..:5800 110000..:00 110000:00 2: :2 p: oo'as0 Lo 1000 0:50 10.0 1100000000 10000 0.p 69 10p0y.0 100.;0 0-80 100.:0 100.-0 ol0e'ss : 10503.'20s 110000.000 00..6533 ole 11S000000000 110007000 1000 LAC`ToAeTxION 100-.0 00- 0 100:.0 111000000.000 100: .0 100; .0 10000?..00 110000.00 00 Company Sanitized. Doesnotcontain TSCA CBI Te 501.2D45a1y6:GaSvuabgcehSounidc iTnoxRiactswithOneGenerason Reroducive Evaluations DuPont5386 - INDIVIDUAL PUP SURVIVAL: F, GENERATION erGROeU-- eP:et1e3-0creD-- OmSE:e0 eMG/eKG-- /D--AY ----e-- eee [p---- snmesn Nsom ALIVE 0-4 ONY VIADILITE iacGmWOaErKon i spiaesssan 10100.0.00 pe : 1i00e0.0 5 1i00n0.0 : "fEdadiaisinosens 100.::0 200.:E0 100::0 f"pirheee 2li0a00e0'0o piel : 11i000700o70 : 1ii0oi0i08oo0 fCis0ne 11000007:00 120000:00 12000000:00 pr"eiasssis 510000:0 iild:o 1i9o0e0:0 pprrrieetdd i11000%70080 1fl00oi70cxo 1Rl0io00o0 ompany Sanitized. Doesnotcontain TSCA CBI TE H9-02-4D5a1y6:GaSvuabgcehrSotnuidcyTionxiRcaittsywith One-Generation Reproductive Evaluations - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: 11-0 DOSE: 0 MG/KG/DAY ajnener spe3m3s20 sSpiie33aae8s0an GGaaanasoonn 88G44a33n4329e17 GS4a3a4a12900 SGaa3aaa0n1se S8a4z3a3s7s8 Ss4aa334na74s87a sazses BORN ALIVE 100-0 110000.:00 -: 111000000..000 100;0 110000.00 100.:0 02000.00 1000 NOWSER OF FEMALE PUPS 0-4 DAY VIABILITY LACDTWADETXION 1000-0 100-0 1000.0 100.:0 100.0 . 200.-:0 101007000 110000..00 100.B0 00;0 100.:0 100.;0 11000000 110000.00 1000 0.:0 11000000 110000.00 1000 1000 DuPont$386 ---- mpany Sanitized. Doesnotcontain TSCACBI ue 9H0.2-4D5a1y6:GaSvuabgeehvSotnuidcy iTnoxRiactistywithOne-Generation Reproductive Evalusions DuPont 5386 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY Taonmeesr mn S00323949 11s 5p0r33e69 1i SSSi2as5as0z bu3d SSSaii3anaaessa 55: 4SS3i64a770653a 5a: poSeis2tieslz} 2> Spr0t75 32 SSSiie3aa20s90s 465 wnmER oF PUPS BAOLRINVE PREDCAUYLLI4NG PODSTACYUSLLING DATT i1s 113 s. s5 11 1u0 s. 5s 111 1156 5:s 5:s 151 32 :: :: 15 : kdi: ':! 35: 14 1: .: 5 22 22 :2 52 01 012 5s 55 15 55 5s 5s DAY 14 DAY 21 08 o8 88 88 e8 8o :0 :o :55 825 0: 5: 2a 3 88 i8 8: s -_-- `Company Saniized. Doosnotcontain TSCA Cat ww. 'H9-02-4D5a1y6:GavaSguebchSrtuodiycTionxiRactistywithOneGeneration Reproductive Evaluations DuPont 5386 -_ INDIVIDUAL PUP SURVIVAL: F: GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANDGL BORN Sseaannas 10` s8Si4i333a35e609 102s GGeeanses H5 GeGeialniese 5 fG434e73 11 4Ga333470630 1Gi34e2n20 7Ss4a33437752 1o 43400 s Sa3as7 0 NOWBER OF MALE PUPS ABLOIRVNE PREDCAUYLLI4NG PODSTACYUALL|ING DAY 7 10a 10. .i i 105s 105s ii5 i:3 s` 5 i5 ii :. 3: i: i: nH u1 ii i1 0- 0- `- i- 7 7- :: i: 10o 10o 40 h0 3 o 3 3 10 1 i i DAY 14 DAY 21 ` "i 333 aai 3a ia i: ': i1 s1 i: +: i: : i2a i5a i i - "ompany Saniized. Does not contain TSCA CBI ww 9H-02-4D5a1y6G:avSaugbeehSrtoundiyc iTnoxRiactistywithOne.Generation Reproductive Evaluations DuPont5386 --- INDIVIDUAL PUP SURVIVAL: . GENERATION GROUP: TV-0 DOSE: 25 MG/KG/DAY NUMBER OF FEMALE PUPS ANIMAL BORN ABLOIRVNE PREDCAUYLLI4NG RODSTACTUALLING DAYT DAY DAY 21 NBER 864433333919 s5 5o 5. :. i" i" 3+ s4e3s3s6e9d n5 n5 n5 33 i: is 33 pG84ae334e5z0 85a 538 78a 3hh 5ii iii 3h3 GGia3aaai1sea 7: 7: 6: h: i: i: h` G4e33437255 54 Gaaa03 $ 5H: 5i s3: 5i2 :i: :3 G54i333a72620 i: - i: i: i: a: :: 8G4i333a7s52 35 25 25 2i 2i 2i 2a 84433337020 57 53 a2 33 ii ii 3qi p84e33d95 :a 5a 5` ih i4 ii a3 - `ompany Sanitized.Doesnot contain TSCA C1 165 9H0--2D4a5y16:GavagSeubcShrtoundiyciTnoRriacsitwyithOne-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL PUP SURVIVAL: F GENERATION GROUP: IV-0 DOSE: 25 WG/XG/DAY Tammsan pprrees sGaan3aeesi S4a33445z0 SSa333aa0sa sea3za1z0s Ssaa33a470s30 8G4a3a3a7z6an i43345725 iSe337a020 eGi333a9s7 SEX RATIO (WALES) 00.6073 00.3336 o0.n50 o: a 00.7533 o: m o: m o0.s0s0 oolsl0 0o's e oWBER OF PUPS BORN ALIVE 0-4 DAY VIABILITY 101000.000 1010001.00 11000000 1100001100 11000000 1010001700 100;0 5p20i5 10000.00 18060.07 0.p0 00p.i0 51:a a0: 110000..00 110000.00 10903.30 1080..70 1100000.00 105030a0 LACTAwToIEOxN 110000.l00 1100000000 11000700l0 100l80 1100000l00 10080 100.80 110000.00 110000100 11000000 --_-- `ompanySanitized.Doesnot contain TSCACBI ww 01.-2D4a5y16G:avSaugbcehSrtoruidcy iTnoxRiactistywith One.Generation Reproducive Evaluations - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY oamneon G0a33239394 SGSaiiaisaeeses0 Spie3rsrayz SSiiesaisea pGae3ae15 GGaiaa30726a GG4ia32u4iz7sz52a GaE4243233497052 pe BORN ALIVE 110000..00 1012000000.000 110000..B00 101000.000 100.80 50. : 1007-0 1100[00r0.e00] 100.0 NUMBER OF MALE PUPS 0-4 DAY VIABILITY wacITNaDETXION 110000.'00 210000.000 11100000000 111000000.00000 010.0.:00 210000..200 1a07%.0 110000.000 100.20 100.fy0 100.20 100.i0 200:70 100A00 12100007000.00 11100000000.000 10020 100.0 DuPont5386 -- mpanySanitized. Donotecontsain TSCACBI TT H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations - INDIVIDUAL PUP SURVIVAL: F. GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF FEMALE PUPS aWmNGsER i613333399 iSi3du6e9s ssii33344520 sSii3aeansa ssaazaaazlse Gsai33aa7003a 8s4i333a72620 psee3nas2 Gi643433334970s20 rere BORN ALIVE 0-4 DAY VDABILITY fNDEX 110000..00 100 101100000..00 111000000...000 11000070 1100070000 110000..00 1010000700 10700s0 110000..00 100.:0 85.:7 1000-0 110000500 101000..800 110000.:00 100:0 100.20 100:0 110000.00 000 110010000...000 111000000.000 102000..00 1060.770 110000..00 10000 [Ee] 100.0 DuPont-5386 - Company Sanitized. Does not contain TSCA CBI -- wm 9102.6D5a1y6:GavSaugebSotnudiy TinoxRiactistyithOne Generation Reproductive Evaluations Dupon386 INDIVIDUAL FUP SURVIVAL: , GENERATION Grou: Vi-o DoSE: 100 MG/KG/DAY wen or sus aTmoamns sow dsoonme praocuaLaG PoasTCeULLING owo mwa mwa l sfuaasmzoe u. x.: u`: .:: .:: `:: ":t wrasrlr on3 iS: is: ::: ::: ::: ::: afansaitte ow ou 5H: ii: i:: ::: i:: ::s ErireE : a:: ::: ::: ::: ::: ::: pfpriereds 5 2 +4: +:: wns ow we i ::: : ::: : :5: : ::: : _ aGans3ss s i 5 i5: i3? and PM i 5:: : 3:: : :: 5: :: 5: _ -- Compaanyny Sanitized,Doss notconTtsacaicany wm H-24516: Subchronic Tovicity 0-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPont-5386 PS INDIVIDUAL PUP SURVIVAL: , GENERATION _-- GROUP: VI-0 DOSE: 100 MG/KG/DAY NOMBER OF MALE PUPS NANoIHMBAELR BORN ABLOIRVNE PRECDUALYLI4NG PODSATYCU4LLING DAY 7 DAY DAY 21 s6sa4i333a3iz2ss08n -3 7 27 2: 2- 7 hn 2: i 2: : a2: ssii3333593 55 Geazesa : s7: 7:: a5! :s: 5!i 5a` sis3i3u3m3a9e : 583337 5 `: 8 `: . i: :: hl3 i . ii! 443342067 3s si3zs7a ! 35: i : Ho : i3 i: 3: 4Se333i3217 i5 Geau708 : s : s : 0a: s03 h0i h! s43e3s45s. s2 Ga34sad : hs` s 3: ii: ii! +a` airsesrnze s2e s7e 32 i3 s3 h3 :3 - CompanySanitized. Does not contain TSCA CBI -- wm 9H-02-4D5a1y6:GaSvuabgeehrSotundiyc iTnoRxaictistwyith One-Generation Reproductive Evaluations DuPon-5386 - INDIVIDUAL PUP SURVIVAL: F: GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NOMBER OF FEMALE PUPS AMNBIELR BORN ABLOIRVNE PRECDUALYLI4NG PODSTACYUSLLING DAT DAY 1s OAT 21 Ssia33a3s2s0e -5 43420 7 72: 72: 2i -2 32- 2: a p4r3e3a39 5i 3i i5 3: 35 :5 H5 G5i13333e3s9e s- 5- 5: i- - `- +: G5S6ii3333aa317763e 7: 1 71 7: 1 i: 1 i:1 a: 1 h:1 G5a333340s77a 5: 5: - : : - : 4i3332371 55 434708 : o5 - 5 :: a: h- a : G4i333a4se5 n10 n1u0 01 hli Geaasad - : : : :i : i3 : ba: apir3aa)ne a3 a3e a3 ai 3 ai +3 ~ CompanySanitized. Does not contain TSCA CBI wm H9-02-4D5a1y6:GaSvuabgeehrSotnuidey TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL PUP SURVIVAL: F GENERATION -_-- GROUP: VI-0 DOSE: 100 MG/KG/DAY NuMBER OF PUPS MmBaErR SEX RATIO OLES) % BORN ALIVE 0-4 DAY VIABILITY AcTEATIxON Gi8343e3s2s0e sa3a20 00..: 5500 6.7 10000 120000.:00 1100007.400 854433333593 Geazesa oolsess : 10l0;e0 101000.p00 110000.500 si8343i3m3a9e si5433a31367 0.: 40 100.0 o0.l5s3 101000710 0 100:0 10500370 100.40 110000700 5a4i3a3z0s77a 843331 o: a 04s 100.-0 00 0:] z :: 5G4a334a27708 isis 0.: 36 038 100.:0 10000 100.0 10070 110000..:00 G4a33344s5ad 8Gi433436303 00:3433 100:0 1000 54s 1000 o's 10000 100.0 100:0 1100010000 --- Company Sanitized. Does not contain TSCA CBI me H-24516: Subchronic Toricity 90-DayGavageStudyinRatswith One-GeneratonReproductive Evaluations - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY aWnMBuER sa54n3a32s0e spav3ea29 rsiezeerse 6S4i333a3793a 6i43331367 sasna3a3s077a p43a3t31 ssii33ia37a00 ssiiz3i3s9ab pSie35r33 BORN ALIVE 6..7 1700800 100-10 100> .0 110000..00 100.20 1000000 10000..00 1002.0 100.0 NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACITNADETXION 100.0 1000 110000.-00 110000..00 110000.00 100-.0 100-.0 100-.0 0.0 100-.0 10000 :0.0 :- 100-.0 200.0 100-.0 100- .0 5>17 200: 00 110000.000 110000.00 DuPont-5386 Company Sanitized. Does notcontain TSCA CBI _--me--_ TT --_------ 0H--2D4a51y6:GaSvuabgeehvSotnuidcy iTnoxRitcistywithOne-Generation Reproductive Evalustions - INDIVIDUAL PUP SURVIVAL: , GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GuEnRa eGE3i34r22n0e G6s4ar3ze3a3os3se psSriii3a3a3n7e GG2r1a0e7 spGraaizzsesre siSpraeoiertyo]n S6Sa5ara3osa BORN ALIVE 1G00:6.10 10500.0 100-.0 110000:0.00 15002 0.00 21000-0.00 10:00 110000.00 [Ep 0-4 DAY vmBILITY 110000:..00 110000300 100:-.0 1i00a00l.0o0 : 1100002..00 10200 11000..00 wacDrEaTKIon 110000>..00 110000..0 100-:.0 110502..00 100::.0 110%02-..0 110000.008 Dupont 5386 --~ CompanySanitDoissnzotecondta.in TSCA CBI TeCT Ti --,------ 9H-02-4D5a1y6G:aSvuabgeehSrtoundiyc iTnoRriacistwyith One-Generaton Reproductive Evaluations DuPont:5386 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ABNEIRL BORN ssseae323a4146737 1110 G4e3i3n38 1is2 sis834ie333ei3s05e i1ss FH] sip3re4v3e0n0) -: 4i3332356 15 Gi8433332785 ns SGii3a3z4s0s8e -: GiG3i4a4z5sde 116 NoMBER OF PUBS ABLOIRVNE PREOCAUYLL4ING PODSATYCUL4LING DN 7 1n10 12103 5s5 5s 5 11 112s 88 s5 1u 1 i1 1 55 : .58 : ? : :` n5 125 s 5o n1 1 15 5 - -- 2- :: v E1B .: 5- DAY 14 DAY 21 oa s5 55 8s 55s 8s8 5: 5: :. a 08 55o -- ?: 5: s- ~~ - Company Sanitized. Does not contain TSCA CBI ww 9H0--2D45a1y6:GavSaugbcehSrtoundyicTionriRcatistwyith One- GenerationReproductiveEvaluations DuPont-5386 ~ INDIVIDUAL PUP SURVIVAL: F: GENERATION GROUP: VITI-0 DOSE: 250 MG/KG/DAY AWODMBLER RY sai3344637 7. 84433441137 s7 8Sa4333333s8 2 s8i633i4c0e0 55 sSiezaena0a0 saas3s3e2s6 5a 54e3332785 `5 Gsiesasziesne :- 3sa3z4a3z00d 1 pit - NOMSER OF MALE PUPS BAOLRINVE PREDCAUYLLI4NG PODSTACYUSLLING DAT s52 so2 ii hh 35 2 38 7 ii i 33 3 55 55 ii 3i :: :- : :s 73 5` i5 o o5 5: s: a: 3! 0- 0- i- a- 2 :: :: :: DAY 4 DAY 21 i. h" ii 33 ha 3: hs ii :: :: 5i 3 i` oa` i: a- :: :: - CompanySanitized.Doesnotcontain TSCACBI hw . 9102-4D5a1y6:GaSvuabgcehrSotnuidcyTionxRiactistywithOne-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY NUMBER OF FEMALE PUPS ANAL BORN BAOLRINVE PREDCAUYLLI4NG PODSATYCUL4L|ING DAY7 DAT DAY 21 joey sSai3344s37 ss Saar : Hs5 5:` :si i.i is .33 sSia3a3l30 s5 s5 `5 ii hi ii 3s sia33a3s3e 7s 3s 35 ii 3h 5i 3i si8433a43400 5- 5: 5: i: i: i: i` 80r33e26n 5: `: s i: i i: a: sis3i3336755 25 si3328 5 s1 5 sa3 Hi5 :5 s5 b5 sis3a3z3aassne - - :- ps- ph: ph: : S6i43344s2s54 73 o5 7! : i: i: P: Ga2i24a : : : B : : : - Sompany Sanitized. Doesnotcontain TSCA CBI ww H902D4a5y16:GaSvaugbechrSotundyiciTnoxRitcistwyithOne Generation Reproductive Evaluations DuPont 5386 -~ INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VITI-0 DOSE: 250 MG/KG/DAY wER OF PUPS MIMI SEX RATIO GMIES) % BORN ALIVE 0-4 DRY VIABILITY wacraTToiomn sGGiraaasreey7 0ool.ls6e2 211000000..000 211000000.000 111000000...000 aGaadannes aloollgs%s 1110000000 11100000000 11100000007000 ESG33ia42s008 oolless 1000000 110000-00 110000..:00 Graerea)na ol:s7 sais: 52.:3 1000:0 GaGGrzaizreees ooollsle 120a00.o00 11070020..007 1100E00H00] GaSarrieeees : -: :: : GGaar2aazsasd ools la 10a0o0 100:0 10080 --~ -- `CompanySanitized. Doss notcontain TSCACBI ww 9H-02.4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generaton Reproductive Evaluations - INDIVIDUAL PUP SURVIVAL: , GENERATION GROUP: VIII-O DOSE: 250 MG/KG/DAY maneax s44a33344a461377 sai3a33n8 Gi8d43i3e3s5 sGie3eee300n GS4i3e3n2n6a GiS3i3337655 sGaaazteese sSaa33aa4s5 SGaa3aaa229n8 BORN ALIVE 1110000001.000 11000000 101000..00 100-0 ss750000 1000: 0 100.-0 -B NUMBER OF MALE PUBS 0-4 DAY VIABILITY LACTTNADTEIXON 101100000.0.000 111000000.000 120000000 11000000 01000.00 110000.00 100.-0 100.-0 as.-7 100:0 1006..-07 0000 100.0 -z -- 1000-B0 100.:BN0 DuPont 5386 Company Sanitized. Does notcontain TSCA CBI -_-- ws 124516: Subchroni Toxicity 2-Day GovegeSud InRigwiteOveGuerinReprodusive Bunions.Dif. onc. ssss - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY wonszz or rms pups fr BORN ALIVE 0-4 DAY VISTLITY wacDrNaDrEiKon saff2aa4ia67 111000000.0000 111000000.000 110000.00 100.0 fffaaeae 1011000000000 1110000000.7000 111000000000 aaasde Eiion 101%00:00 1100.0.i00 1100000.:08 pEEaahndieas 1010000:00 1100007:00 12000:00 GGaanzea Ganson 10S0o.l0o 1a000.:00 10o0:o0 faCCnaasnaiiseo 10x0:} 10070 :: 1000:0 fia p BN : - --- ompanySanitized. Do note conts ain TSCA CBI ww 1.24516: Subchronic Toxicity 20-DayGavageStudyinRatswithOneGenerationReproductive Evaluations DuPo-5366 APPENDIX GG REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP WEIGHTS: F; GENERATION - `Sompany Sanitized. Does not contain TSCA CBI | 9204-5D1a6y:GavSaugbcehSrtoundiyc iTnonRiacistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP WEIGHTS: F; GENERATION DuPont 5386 EXPLANATORY NOTES Footnotes: a Nolitter delivered. b Two pups were missexed; data excluded from male and female mean pup weights. One pup was missexed; data excluded from male and female mean pup weights. d No male pups born. e Nolive pups at birth. J Found dead Day 22G (Test Day 99) Recording error, data excluded. No male pups bom alive. i Accidentally killed Day 14G (Test Day 91) J Founddead Lactation Da0y (Test Day 106) Nolive pups on Lactation Day 4. 1 Nolive pups on Lactation Day 7. - Sompany Sanitized. Doss not contain TSCA CBI ww H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont-5386 --~ Individual Pup WLeaicgthattsio(ngrDaamys)0: Fi Generation Group: 11-0) Dose: 0mg/kg/day ml Naber mp Sex 1 2 3 4 PupNumber 5s 6 7 8 3 111 -_ sa sa3ess sa33040 77..4500 67.1500 77..6000 77..0400 77..4300 77..7400 87200 s8l3a0 771.2500 5100 840 7.70 8.20 8.20 8.30 8.70 8.10 8.20 se34s0 aamsa 76..5200 88.4500 78..4000 78.14100 87..0300 77..9500 7.80 7.90 7.70 sansson suze se3307 56..6700 671.2100 66..2200 66.18400 661.3400 66..4000 66..6200 6.40 6.00 6.20 730 7.20 7.30 7.50 30 7.00 7.00 7.20 sam 765.5000 66.2700 57.1200 66113300 66.2600 66..3700 s.e0 6.50 67 6550 630 6.20 5.20 s.60 -_-- Company Sanitized. Dosnotcontain TSCA CBI TIE H9-02-4D5a1y6G:avSaugbechSrtoundiyc iTnoxRiaciistwyithOneGeneration Reproductive Evaluations Dupont-5386 - Individual Pup WLeaicgthattsio(ngrDamasy):0 Fy Generation Group: 11-0 Dose: 0mg/ka/day a PupNumber Wamber Sex 1 2 3 4 5s & 1 8s 3 0 nu wm EE -- saa10 sasan4a 75.15600 76.5200 76..3500 66..5000 76..0000 7.10 6.60 6.00 5.60 6.90 6.40 sa2e0 seis nme per 55.3100 65..2000 65..6200 6.30 6.20 6.90 6.00 6.20 6.40 5.40 6.10 5.30 75104000 6519500 6613600 66.5900 66..6700 75..500 7.00 7.20 6.90 88.7100 69..6200 77..3500 7.30 8.60 sasaar 561.2600 66l.6300 661.2200 66.15400 66..4700 76..0600 76..5200 6.50 6.60 5.50 7.10 6.50 e347 5S110700 671.2000 66.l4s00 66..6500 56..4500 66..4200 6.80 5.80 5.60 se3306 s6i1s400 261030 56117300 6613300 66..0400 6.70 6.20 7.00 6.40 6.30 - Company Sanitized. Does not contain TSCA CBI iw 9H0-2-4D5a1y6:GaSvuabgcehSrtouidcyTionxiRactistywithOne-Generation Reproductive Evaluations DuPont $386 Pa Individual Pup WLeaicgthattsio(ngrDaamys)0: Fy Generation Group: 1-0 Dose: 25 mg/kg/day aMnuibmearl anne esses saase ere sasnaz sa3a38 sesaise Speuxp 1 2 3 4 5sFup lu&mber. 7 8 5 1.0 um E75E5T0 s7.m40 s7.w50 8T11e0 7.50 7.60 7.80 7.50 7.00 7.00 663300 6703100 66.2200 76..4300 56..2600 6.60 7.00 6.40 7.00 6.00 683100 770.4500 671.5400 8.20 7.20 8.20 7.60 6.90 7.20 7.50 6.80 6610500 56157300 66.0300 66..5100 66..2500 57..0600 66..8100 5.20 5.10 6.00 5.60 75..0600 663400 656700 66.4400 66..2500 6.80 6.60 6.70 5.00 761:6200 762300 77..3400 66.3000 65.i5500 66..5700 66..5600 67..9200 660200 6613300 553.8300 56..8100 56..4000 56..6000 6.20 6.40 seats 761.0800 66.18100 66..3600 64..6300 66..9300 66..7000 66..8400 6.90 sazzs 76:8200 66.5800 57..8500 77..1200 7.10 6.50 7.00 7.50 6.30 6.70 7.30 ~ Somp`apanynySanDioestnoticonztaie nTSdCAc.pt he 1902-4D5a1y6:GavSaugbcelSrtoundiyciTnoxRitcistywithOneGeneration Reproductive Evaluations Dupont5386 -- Individual Pup WZeaicgthattsio(ngrbaamys)0: Fy Generation Group: 1v-0 Dose: 25 mg/ka/day Wreoesrs Smep 12 3 4 sPBeusnter 1 8 5 10 wm sanvoan E0w0 7.50 7.70 7.60 7.30 7.20 aaa sarumn 6o.p50 56.5700 76.7400 66..9500 7.40 6.60 7.40 6.80 6.90 7.10 siausz carursd san a3a00 sanose sist 7.750 27.5300 67.s00 77.1300 67..9500 7.80 6.60 77.6400 60 2760.1003000 651.0500 67..2000 s7.s3o0 77.00 74..5900 6.00 6.70 7.20 sSl6i0 7150 5614000 630 s61l0o0 610 s5.i5e0 5al.d3o0 55.3100 5.50 5.70 613400 S40 5615000 600 6615400 620 6.0300 sim 66.1200 00 55.5900 5.80 5.30 6.50 6.90 - EE ompany Sanitized. Does not contain TSCA CBI | -- 0H--2D4a51y6:GavSaugbeehSotnuidcyTionniRcatistywithOne.Generation Reproductive Evaluations DuPont-5386 - Individual Pup WLeaicgthattsio(ngrDamasy):0 F; Generation Group: vI-o Dose: 100 mg/kg/day iE Waber ne Sex 1 2 3 4 Pup Number. 5&1 8 5 10 nm wm Geaesea 2m000e7w.30 e220 se3a39 sansa sessese 661.0400 66.10700 66..7700 67..4000 76..2000 56..8500 56..4800 66117800 7s1l0s00 65.11300 5.70 5.40 6.90 6.80 571.1500 781.4500 78..4500 87..3100 8.30 sens sama 671.3400 661.5800 66..3500 66..3700 66..4200 66..2700 6.20 6.50 5.80 03337 661.5400 561.5200 66..6400 66..5800 66..5400 67..1200 65..2600 7.20 sesae 67..0000 6:20 7.20 7.60 7.00 _-- ampany Sanitized. Does not contain TSCA CBI ToT 2904-5D1ay6:GaSvuabgcehSotuidcy TinoxRiactistywith OneGeneration Reproductive Evaltions DuPont5386 - Individual Pup WLeaicgthattsio(ngrDamasy)0: Fy Generation wigie Weber ToT sasasza Group: vI-0 Dose: 100 mg/kg/day 20 Sex 1 2 3 4 up umber ss 1 ss E50w0 4R5w0 E54w0 s4w0 5e.2w0 5E.m20 6E.0m0 6.30 5.40 wm om seamne e3027 as3e08 67870 677000 67.7000 67.7800 77..3000 7.00 7.30 7.30 7.10 sasa3a sass 657500 650 56..7000 5130 665255000 66.2500 630 s57e0 6.40 66.2500 6.20 66.370 6.50 5.80 5.90 saaeset 620 610 610 6.00 5.60 6.70 6.00 5.60 6.20 6.40 6.00 sarang se3460 82.6200 57.02500 73.2600 67.7700 87.3200 87.200 27.3300 ~~ ompany Sanitized. Doss not contain TSCA CBI --- wm 20H0-:5DD1aa6yyG:GaaSvvuaabggeeehSrStotunudidycyiTinnoRsRaiacttisstwywiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuattiioonnss DDuuPpoonntt-55338866. -- Individual Pup WLeaicgthattsio(ngrbaamys): Fy Generation Group: vizio Dose: 250 ma/ke/day AWneibmearl PSuep 1 2 3 a Nuspumser 1s 5 1 WE casas T65I0 200 esoe 620 ewwm 720 Tcma 320 T7.m00 640 TT 730 Th 70 Te po s3a0 750 e61a0 sao 6s0o so 65o3o0 rao 56900 6.00 sane dSo3o0 c7a0o 6 G0 7ce2o 25.3s0 sao 30 anne cans SS6E0 50 6s3s0 em 6c230 530 caa0 730 s0ee ceo 6T840 060 cso 6.80 6.0 caaass 28o00 Tso 25l100 ea s78s0 le 7s6a0b eso 600 7s 1s.a6o0 a5.090 70 7.60 caus sara208 63000 0 60 csulbo ss0o 6s3o0 6S8eo0 661500 62..000 65..1600 caranna _ - SompanySanhized. DoesnotcontainTSCA CBI wm F0--2D4a51y6G:avSaugbcehSrtonuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 ~ Individual Pup WLeaicgthattsio(ngrDamasy):0 Fy Generation Group: VIII-0 Dose: 250 mg/kg/day mw wp Naber Sex 1 2 3 4 upNumber 5s 5 7 8 3 10 ww S 30wefso s61w0 esswo e63m0 6e.0s0 em sezss 7s000 765600 27.0300 7.20 7.50 sazarsh 5.30 suze se33a0n SS3800 s5.l3o0 6s.s0o0 4si9200 5s.o2o0 sso 6a2a6t pe Ge3a293 6s.40s6o.80 6s.2200 s6.i9s0 66.2800 s6.e1o0 65..2700 6.50 5.80 6.10 ry -- ompany Sanilized. Does not contain TSCA CBI hw 29H0-0-2-D4Da5ay1y6GG:aavvSaauggbeeehSSrttounudidycyiTinnoRxRaiatctsistwywiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt--55338866 ~~ IndividualLaPucptatWieoinghtDsay (4grPamrse)c:ulliFnygGeneration Growp: 11-0 Dose: 0 mg/kg/day J Number Sex 1 2 3 4 Pup Number 5 71 a 35 1 nu 1 EE 3343 si3uss sansa 11221.1100 1132.9000 1122.07000 11221.1300 1132..1200 1122..1600 1112111300 1120113100 11031.5200 13180 1350 14.20 12.10 13.00 12.70 13.80 13.60 13.30 43400 sansa 11361.4600 1144.12300 1132.03700 1112.17500 1133..2900 3122..3900 12.20 12.40 12.40 seaasoa suze 31001.5200 11001.4900 11001.3200 191..5100 1120.14400 13021.4700 2101..0700 3.90 3.20 10.90 a7 20.60 9.20 12.00 10.90 1160 12.50 12.80 12.30 11.90 11.40 12.70 10.50 10.40 9.70 11.50 10.80 saan 1120 920 11120 8.60 8.80 11.60 5.10 9.30 10.90 10.20 10.20 10.20 - ompany Sanitized. Doesnotcontain TSCA CBI ----ie---- H-24516: Subehronic Toxicity 90-Day Gavage Study in Rats with OnGeeneration Reproductive Evaluations DuPont$386 ~ IndividualLaPcuptatWieoinghtDsay (4graPmrs)e:culliFnygGeneration Group: 11-0 Dose: 0 mg/kg/day ANnaibmearl Speuxp 1 2 3 4 5s Ri6p uns1er 8 a 1 nu au we sa3a1s saaanea 1121.5700 1121.05400 1112..6200 192..7200 150..8600 12.50 10.60 5.80 12.10 10.80 9.30 sasa01 sanass 43378 sa330aa 150..0100 190..2300 180..4000 11.00 10.10 9.70 9.80 10.00 9.60 10.20 10.70 9.70 150..3100 1501.8300 190..7500 190..7900 1110..6500 1110..3300 11.60 10.60 10.30 1365.5200 1125018500 1153..7400 16.60 14.70 se3aa7 190..5700 1100..8800 95..8300 93.4600 53.9500 190..7000 65..3800 11.00 9.50 11.00 10.90 9.90 se3a78 3201..8700 1302111200 1101/.0400 1100..5400 1101..5900 2200..3900 1131..9600 11.30 pees 191..5200 11001.4000 190..5400 1102..5600 190.5600 10.50 12.10 9.80 10.20 3.40 -- EE mpany Sanitizad. Does notcontain TSCA Cat -- F9-02-4D5a1y6G:aSvuabgcehrSotnuidcy TinonRiactistywithOne-Generation Reproductive Evaluations DuPont 5386 -- IndividualLaPcutpatWieiognhtDsay (4graPmrs)e:culliFn;gGeneration Grove: 1v-0 DOSE: 25 MG/KG/DAY Manuiwsearl WS sane se3i6a se3369 sesso e302 sa3a38 Garsasa sass sanzs Spuepx iz 3 4 5 up u&mber 1s 3 10 mu D131e20 1n2/w40 1E2.R30 E12.O60 m11.e80 E12.n50 11.60 11.50 1100.17000 1200/0800 1200.2000 190..7700 1100..0800 11.30 11.00 10.50 10.30 10.80 2133..0200 1113./7300 1112./8200 1113..8200 1122..5600 11.80 12.00 13.90 11.50 190..5200 180.15700 5.90 10.10 59..4400 3.30 95..1700 8.70 69..9500 1111..5200 190..8200 10.20 10.50 9.40 10.10 9.70 39..8400 1100..2200 10.50 193..0000 183..0200 160..3800 180..3200 10.00 12.60 12.50 12.10 1120..2000 1101/4200 1112..0000 2100/.4500 131..6800 1100..5500 11.70 11.20 9.30 10.10 10.80 9.50 10.50 9.80 10.30 11.70 11.10 11.30 31.00 11.00 10.10 10.80 21.20 11.20 11.70 11.60 10.60 6.10 1112.5400 113214500 1122.3300 1131..0500 12.80 13.60 12.60 13.20 12.80 12.90 12.80 - `Sompany Senitizod.DoesnotcontainTSCACBI Tw - H24516: SubchronicToxicity 0-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont 5386 ~ IndividualLaPcutpatWieiognhtDsay (4graPmrse):culliFnygGeneration Group: 1v-0 Dose: 25 ma/ka/day NAabaesr Speuxp 1 2 3 4 5heslabe 1 8 5 10 nm Tes sassona 1m21a70 14.50 13.70 13.70 14.40 14.20 sa3376 sesizan 190..5400 1103..5400 1101..0100 2100..5100 10.50 20.80 11.10 5.80 5.70 11.70 seni sanarse ann 6a3400 sasses sanes7 1121.6600 1322..7400 1111..0800 1111..5700 1112..7700 12.30 11.10 1150.11100 11301.2500 11.10 11.10 10.40 10.00 12.20 13.00 11.00 3.60 170.17300 180.17900 170.11200 190..7900 93..2000 93..5300 88..6600 7.30 1876.600 1830.800 1821.1400 173..8000 1123.17200 1123110200 1124.14300 2122..6500 11.30 11.20 11.60 10.80 10.50 11.50 1200 10130 20.50 11.20 11.70 -- - ompany Sanitized. Does not contain TSCA CBI ww 9102-4D5a1y6:GavSaugbeehSrtoundiyc TinoxRiactistywithOGneneration Reproductive Evalustions Dupont-538 -- IndividualLaPcutpatWieoinghtbsay (4graPmrs)e:culliFingGeneration Group: VI-0 Dose: 100 ma/ks/day M[eeberr se 1 2 3 4 5Es upNNu&umsbbeerr 1s 3 0 um ann T241H10 T1400 caressa aaa 151..3200 1130..0500 1100..6500 151..5100 190..2400 1110..0700 2100..2200 cars 1$20..0300 1133..3600 1102..4400 13.30 10.20 13.60 12.30 cans 1104.75400 1163..7700 1145..7400 3164..5600 15.00 cannese ans 11901.0500 1101.16300 151..6700 1110..2300 181..4300 190..5400 11.20 10.60 10.30 numa carn 1310.10600 1111..4400 1122..0700 1103..9700 1121..7000 181..5500 1112..5500 11.10 saaa1s 1103.17300 13740 13.90 13.00 - Sompany Sanltized. Doesnotcontain TSCA CBI Ti 0H--2D4a51y6:GavSaubgcehSrtoundiyc iTnonRiactistywithOneGenersion Reproductive Evaluations DuPon-5386 _ IndividualLaPcutpatWieiognhtDsay (4graPmrse)c:ulliFyngGeneration Group: vI-0 Dose: 100 mg/kg/day wp Mer Tp Sx 1: 2 3 4 Pup unber ss 1s 5 1m ou a ears same e327 a3ar08 ana sa3a0 pre 643333 sa3460 12.50 11190 11.70 13.30 11.00 11.60 12.10 11.50 11.50 13.10 11.70 11.70 11.40 12.00 39.2900 89.5900 160..9000 1100..3800 35..4100 87..8100 8.80 8.70 3.80 3.00 16.30 10.10 10.20 10.40 5.00 10.60 8.30 10.00 9.80 5.40 8.60 10.50 8.90 9.00 9.80 8.30 8.10 11451.8600 1143.06400 1133..0800 13.50 1122112500 1122..2400 1122.,2300 1121118400 11220.0900 1122..2800 1121..6300 -- CompanySanitized. DoesnotcontainTSCACBI THO H902-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont 5386 -- IndividualLaPcuptaWteiiognhtDsay (4grPamrse)c:ulliFnygGeneration Group: vITI-0 Dose: 250 na/ka/day Wseabsesr S pp 42 a =up womber as 6 1s sw Tamer T5o50e T83e0 1S0.E00 sSeIo 1B0.e00 7% 5 5 a0 11133%0 i13l3o0 11215300 1s2.o00 112680 12.40 13.30 saonr SS5500 1e0e 90.30 17..2800 9.40 10.70 sae 0S.4800 1171.17300 1110.7500 1121.4700 191..2600 12.30 10.90 ane iilloo n12l0s0 1m1a3e0 1n1.s30 11317 m 190..3400 31.00 10.70 sans Saas 004400 1530 180.3800 12.20 38..2400 10.20 11075500 1040 1916400 12.50 11101.5000 11.7 1102..1300 5.60 8.20 10.80 sees 15060 990 a5.6l0 5l% 11.04300 0.60 11112200 1050 1110..0000 5.70 190.0.09 1100.3300 1101.0800 1101..2100 sa3a300 aes --- `Company Sanitized. Doesnotcontain TSCA CBI Tr 9H-02-4D5a1y6G:avSaubgcekSrtoundiyc iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5386 ~~ IndividualLaPcutpatWieoinghtDsay (4graPmrse):culliFingGeneration Group: VITI-0 Dose: 250 mg/kg/day sigs TD PupNumber Naber Sex 1 2 3 a s 1s mE T11W70 m10e2r0 W11.w10 T11.m30 1s0.e50 w10.w30 643365 lols 5.30 12.10 5.70 11130 11.30 10.80 10.20 seaarsh e332 se3sesn 1508200 1111.3700 191.4200 171..5400 sw seanesd si30e9 6436299 15.5000 1102..8200 1100..3400 1110..3100 89..0900 89..6700 88..4600 10.10 $.70 8.60 Geae2an - ompany Sanitized. Does not contain TSCACBI 207 9H-02-4D5a1y6:GaSvuabgcehrSotruidcy TinoxRiaciistwyithOneGeneration Reproductive Evaluations DuPont5386 - IndividualLaPcutpatWieoinghDtasy (4grPamoss)t:eullFiingGeneration Group: 11-0 Dose: 0ng/ka/day wan 7m Wober Se 1 wm up Number 2 3 4s 643343 1132.0000 1m2i.s3o0 1122.1200 1122.16300 ears 112203300 11008000 1135.200 1420 12.70 senses sium 14600 113.030 1133.2500 1122..2300 suanoa sesso anes 00.4200 1s0s.500 1111..000 192..2700 43397 0105600 1112..3000 192..7800 10.40 10.80 saz wa 10050 1902.200 1102.200 1s0.e20 - `Company Sanitized. Does not contain TSCA CBY T308 9H-02D4a51y6G:avSaubgcehSrtoundiyc iTnorRiacistywith One Generation Reproductive Evaluations DuPont5386 ~ IndividualLaPcutpatWieoinghDtasy (4grPaomsst)o:ullFiingGemeration Group: TI-0 Dose: 0mg/kg/day air Nimer Bp sex 1 upNumber. 23` s mE seaa29 si3a1ea 11.060 1m0i.6o0 1102.600 192..8100 saza01 sans 643378 anon 15..0000 190..1100 89.4800 10.00 10.20 1100.3500 1$17.500 191..7300 1110.6600 1151050 1125..8500 1153..7400 2660 10.70 aaa7 190..5600 1603.600 99..8900 190..9500 srs 120 1000 10.30 31.30 10.0 10.50 10.30 11.60 saree 120 10ls0 10.50 310 5.50 10.00 10.5 3.60 - Company Sanitized. Doss not contain TSCA CBY Eg 1902-4D5a1y6:GavSaugbehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont 5386 --- IndividualLaPcutpatWieoinghDtasy (4grFaomsst)c:ullFiingGeneration Group: 1V-0 Dose: 25 mg/kg/day rote up Pup umber Weber Sx 1 2 3 4 ss D wwem12o 040 12e .30 1n 2.60 1e 3.80 mn aan 110007800 1100.18200 351..7000 1100..3000 sees 113116500 1122..2600 3123..0200 1122..500 63369 1#051200 1100..2700 150..4200 153..1500 snes 5Si0o0n 88..7000 180..3500 180..3200 ane 1101.18400 1102..0000 1220..5500 1112..1700 ase39 1100702800 152..5000 190..6500 190..5500 sarsise sae 1111..0300 1100..6100 1111..2600 161..2700 saazs 1121.03400 1121.08400 1123..6300 11311.2500 - Company Sanitized. Doas not contain scacal 05 0H--2D4a51y6:GSauvbagcehrSotnuidcy TinoxRiactistywith One-Generston Reproductive Evaluations DuPont5386 . IndividualLaPcutpatWieoinghDtasy (4grPaomsst)c:ullFiyngGeneration Group: 1v-0 Dose: 50 mg/kg/day otis op Puptuner Naber Sex 1 2 3 4 5s m12s 170 14.50 13.70 1m 3.70 14.40 14.20 se3s030 643376 senaz20 150..5400 1120..2500 1100..0500 1101..2700 sasas2 sanarsd sanz 4300 Geass eae? 11121.6400 1122.04700 1111..7500 1112..7700 1151.1200 11031.4500 12.20 13.00 180.3700 170.9100 190.10200 37..2500 182..6600 163..0800 153..1400 173..8000 1131112700 1123.10200 1142.14100 1121..5200 12700 10.30 10.50 11.20 ~ --_-- `CompanySanitized. DoesnotcontainTSCACBI 'H9-02-4D5a1y6:GavSaugbcehSrtaundiyc TinoxRiactistwyithOneGeneration Reproductive Evaluations DuPont-5386 ~ IndividualLaPcutpatWieoinghDtasy (4grPamoss)t:cullFiyngGeneration Group: VI-0 Dose: 100 mg/kg/day Si Wurber mmm pe 0 up Number Sex 12 3 4s 1o6m12e0 m16.m00 saraz0 se3039 sa3ss3 sesasse 11.00 9.90 10.40 10.20 1200..5200 1103.16600 1113.3100 1101..2000 13.60 1126..0400 1136.13700 1206..4500 15.80 10/60 13.70 15.40 18.60 su339 senna 1100.0500 150..6600 191..9200 1110..2400 5337 12.70 11.90 11.50 12.50 12.00 1.70 8.90 11.50 senate 1103.17300 13040 13.50 13180 EE Company Sanitized. Does not contain TSCA CBI 1902.4D5a1y6:GaSruabgleoSnuidcy iTnosRiactstywithOneGeneon Reproductive Evalstions Dupon5356 _ IndividualLaPcutpatWieoinghDtasy (4grFaomssc)c:ullFiyngGeneration Group: v0 Dose: 100 ma/k/day ASnoimmbaelr RIoa up aNumber es mmm pre pre csaannee?s 11126500 1112.5700 1111..0700 1121..3400 sane sass C5.a30 1030 1T0i.0o0 10.40 1ss0.0o30 a58.6k400 sunset Soo 830 a0 850 cnn 1150.8600 1130..4600 1134..6000 13.50 canes 1E5h0 0 A 1a30s 2 a1l2s0e - Company Sanitized. Does not containTSCACBI TE H9-02-4D5a1y6G:avSaugbeehSrtonuidcy TinoxRiactistywith One-Generaion Reproductive Evaluations DuPont:5386 -- IndividualLaPcutpatWieoinghDtasy (4grPaomsst)c:ullFiyngGeneration Group: VIII-0 Dose: 250 mg/kg/day NAnuimmbaelr TET saan pe sa3413 suze sana senses ssaa0 aa3e308 PSuxp 1 2 53S ss W8.3m0 230.030 T8.s80 1S0.o00 1.20 12110 12.80 12.30 152..5300 1131..6000 192..3300 172..2000 190.55300 961.2500 182..3300 1110..8800 1121..0300 1101.17300 1131.14300 1111.16700 110106400 1111112700 1121114500 191..3000 11020.4200 1815.700 38.i4600 180..2500 95..5500 1110.14300 1101..0200 1110..0800 10.60 10.50 3.70 11.00 --- Company Sanitized. Does not contain TSCACBI T5 9B-02-4D5a1y6G:avSaugbcelSrtoundiyc TinoxRiactistywith OneGeneration Reproducive Evaltions DuPont-5386 ~ IndividualLaPcutpatWieoinghDtasy (4grFamoss)t:cullFiyngGeneration Group: vIII-0 bose: 1000 n/kg/day SAonmimmearl Pup. oaa a BopSuper as E E111%w T D110R30w 1050 2w 0030 canes 130.03800 131.7100 1111..3300 10.60 10.20 saazrsh s.00 canna 130.8300 1111..3700 191..2400 171..5400 cannaen pre sans 1120.4200 1110.1300 98..0900 150..6100 eaau2s sarees - `Company Sanitized. Doesnotcontain TSCA CBI i 9H-02-4D5a1y6:GaSvuabgcehrSotnuidcyTionxiRactistywith One-Genersion Reproductive Evaluations DuPon-5386 _ Individual Pup WLeaicgthattsio(ngrDaamsy):7 Fy Generation Group: TI-0 Dose: mg/kg/day aMnmtbrearl SPuepx 1 wm 2 Nupum5ber 4s Genes seuss u3ssan 1158.4400 1196..0700 1189..6700 1169..8700 2127700 220105700 12521.0700 22.40 20.30 sa3480 sannsn 2Isl20 221..1400 2220.2200 220.1900 sansa anes 1197.3400 11660.3900 2108..7200 1188.5300 ener 160 20000 22.10 1830 16.90 19.40 16.80 18.10 sen 36.00 13.70 14.40 16.90 10.50 15.00 15.10 15.80 - Company Sanitized. DossnotcontainTSCA CBI Ti H902.4D5a1y6:GaSvuabgeehrSotnuidcyiTnoRxaitcistywithOne-Generation Reproductive Evaluations DuPont 5386 - Individual Pup WLeaicgthattsio(ngrDaamys)7: Fy Generation Group: 11-0 Dose: 0ma/ka/day Min 29 Number sex 1 upNumber 25 s -_-- e309 sesanea 1692.500 1179..9000 2180..4000 1186..2700 se3s01 Genus 43378 sansa 1174.l000 1175.15500 1175.10500 17.40 16.60 a6500 11871.7400 1177..2300 1165.3500 11580l4000 2220..5000 2125..0600 23.00 13.70 43447 1167..5200 1188..7700 1185..3800 1157..2700 coun 116i0700 1176..1400 1157..7500 1155..6200 643386 1168.600 11970.0400 1159..4600 1178..3800 - Company Sanitized. Doesnotcontain TSCA CBI mT 9H-02-4D5a1y6G:avSaubgcehSrtoundiyc TinoxRiacistywith One-Generstion Reproductive Evaluations DuPont 5386 ~ Individual Pup WLeaicgthattsio(ngrDaamys)7: Fy Generation I Dose: 25 ma/ka/day ia. Moher Wp sec 1 upNumber. 2345 Tm G191m30 1E9n70 L19.H20 L18.o80 sane 1176..6700 1184.4000 1198..3500 1159..8400 sense 1166..5900 1167..5300 1169..1300 1178..1000 senzes 1155.0500 1174..7600 1166..3400 1176..5400 saaas0 1520 17.00 17.20 26.30 14.90 15.60 16.00 15.70 sanez 1166112800 1189..0400 1187..8500 1198..3300 sa338 11761.1400 1157..8500 1166..4700 1178..4400 sarsasa sana1e 9.20 15.30 17.80 18.80 17.20 17.70 18.80 18.20 6a332s 2115..7000 2125..3600 2201..7500 1292..7800 Company Sanitized. Doss not contain TSCA CBI Eg 9H-02-4D5a1y6G:avSaubgcehSrtoundiyc iTnoxRiacistywith One-Generation Reproductive Evaluations DuPornt5386 ~~ Individual Pup WLeaicgthattsio(ngrDaamys)7: Fy Generation Group: 1-0) Dose: 25 mg/ks/day I PupNuumsnbbeer Number Sex 1 2 3 4 5 m21.e00 21.40 19.10 16.10 19.60 20.50 sana0a san76 sanaze 11571.0700 1196..2600 1255..6100 1167..2800 saasz sa3arsd sunm 43400 sanss saaas7 19.40 16.30 20.10 19.30 19.60 18.40 18.00 28.20 2227.15500 2107..6000 18.80 17.50 1127115100 1187..4000 1153..5000 1150..8600 1139004400 2101.5500 2120.4800 2221..2200 11591.5300 2109..6000 1138..0700 1270..5400 16.20 18120 17.80 17.30 -~. Company Sanilized. Does not contain TSCA CBI Eg H9-02-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont:5386 -- Individual Pup WLeaicgthattsio(ngrDaamys)7: Fy Generation Group: VI-0 Dose: 100 mg/kg/day aNnismmbaelr wm seaasn saaaze saaa30 as aannese e333 saan sa337 pee SPeuxp 1 2 op u3mber 4s m211m30 a2.m60 17.10 17.40 18.10 17.80 1270.17500 1167..9800 2108..8500 1166..3500 20.00 1273.11500 2138..3000 2210..3000 23.50 20.80 22.40 20150 16.20 1177..5700 1186..1000 1177..1500 1175..0300 1260..5300 1159..5300 1291..4700 30.30 15.70 11751.7000 18.10 13.20 19.00 -- Company Sanitized, Does not contain TSCA CBI Es 9H0-2-4D5a1y6:GavSaugbcehSrtoandiyc iTnonRiactistywith OneGeneration Reproductive Evaluations DuPont-5386 _ Individual Pup WLeaicgthattsio(ngrDamasy):7 Fy Generation Group: VI-0 Dose: 100 mg/kg/day aNnmibmearl pSuepx 1 2 upNu3mbers. 5 wer sansna saasne e327 Gasar02 ee saases saaasaf saan sa3a60 19.80 17.80 15.50 19.20 19.20 15.00 15.30 15.30 1174.1200 1105..5800 1151..3400 1160..3700 16160 15.40 17.60 13.70 17.60 14.80 15.40 14.00 2200..9600 2123..7700 2201..2300 19.50 1166112200 2156.10000 11551.9100 1135..9500 --~ Sompany Sanitized. Doos not contain TSCA CBI Es 9H-02-4D5a1y6G:aSvuabgeehrSotnuidcy TinoxRiactistywithOne.Generation Reproductive Evaluations DuPont 5386 --- Individual Pup WLeaicgthattsio(ngrDaamys)7: Fy Generation Group: VIII-0 Dose: 250 ma/ks/day wa upNumber Wrber sex 1 2 3 ` s wwe mmiasre 1W36m0 1m5.w60 1m1.w30 si34a3 1l8e0i3s0 1230.2000 1139..5600 1290..5200 swa17 2100000 1172..2900 19.6s0 194..0500 suas 1le0s0 1168500 1166..2500 1185.14200 sease 11667500 1165..0900 1145..0800 1166..5300 ans 1192500 119s.6.0 1178.3600 1175..8200 si3ese pllaao 16100 1127.000 1177.2%0 as3us0 11222700 112300 11208800 11117500 saana0n senna Company Sanitized. Donote contsain TSCA CBI Ey H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont 5386 _ Individual Pup WLeaicgthattsio(ngrDamasy):7 Fy Generation Group: VIII-0 Dose: 250 mg/kg/day --" PupNusber Humber sex 1 2 5 . 5 Tm W1.7e0 16700 m17a.8o0 w15.s80 sa3zes 114206300 11420500 1124.8300 13.60 14.60 saamshil a3nze saznaea 1127..2600 1156..0000 1167..2300 1174..3600 saszast sa344s 6434299 1155..2800 2170.3100 1175.06300 1153.5800 preven -_-- Company Saniized. Does notcontain TSCA CBI mw H902-4D5a1y6:GaSvuabgeehSotnuidcy iTnoxRaitcstywith OnGeneration Reroducive Evalustons DuPone:5386 _ Individual Pup WLeaicgthattsion(grbaamys):14 Fy Generation Group: 11-0 Dose: 0 mg/ka/day et Ter Zo S12 Pup number a 4s FE ce 3376.0300 4a0s.9e0 1397.2200 3370..3700 cusass BSeilo 14v.0e0 a40e.s500 400 45.20 presen coaeno 13.s30 4a5n.0s0 4a3.070 436.s30 cuamsa casason cases 33s0i.c2o0 43283800 036..1800 4401..1000 cans H30e0 3353800 33.el0ke 335..2200 ean 0S1060 33303600 3320.3100 3342..1800 - Sompany Sanitized. Does notcontainTSCA CB pg 9H0-2-4D5a1y6:GavSaugbechSotnuidcy TinorRiactistywithOne.Generation Reproductive Evaluations DuPont 5386 -. Individual Pup WLeaicgthattsion(grDaamys):14 Fy Generation Group: 11-0) Dose: 0mg/kg/day FR PupNumber Narber sex 1 2 3 a s wm pee Gaara 348.5300 4421.1100 4402..7900 4411..6300 saas01 Guess 643378 senasan 3355..7000 335..3700 3363..3800 37.40 35.30 33260.3200 3305.16300 3354..3500 3350..2500 3160.07100 3369.l9600 3338..6200 37.30 10.60 pe 3394.0500 3367..4500 3375..3500 3348..3000 sams 3376..2500 3376..6500 338..8800 3387..7400 anne 3379.02600 33991.2600 1307..2500 4307..3400 -- ~ompany Sanitized. Does not contain TSCA CBI 0 9H-02-4D5a1y6G:aSvuabgcehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont:5386 -- Individual Pup WLeaicgthattsion(gDraamys)1:4 Fy Generation Group: 1v-0 Dose: 100 mg/kg/day RT Nimber Gx 1 Pupdunes 2345 6 Tm 3m7.w40 3m7.w30 m 38.70o36.30 sas3se 3378.11300 33841.5600 3376..6000 3385..2300 Genes 3378..5300 23081.1200 3387..2900 137..1400 643369 3356.13000 3377..9200 3345..4700 3386..3200 ree 35.10 37.70 34.30 36.50 reer 3339.18300 2441..8700 3383..2700 3862..3700 e330 3354118500 3302.15800 3307..3700 3396..1900 37110 34140 36.50 32.50 sesaase e310 35.00 37.80 38.30 25.10 37.60 36.10 37.90 38.10 sa3azs 4472011200 245018200 3465..9400 4440..9600 ~ `ompany Sanitized. Does not contain TSCA CBI 5 1902-4D5a1y6:GoSvuabgcelrSotndiyc TinoxRiactistywith OneGeneration Reproductive Evaluations Dupont5386 - Inaividusl pup WLeaicsthattsion(gDraayms)1:4 Fy Generation Group: 1V-0 Dose: 100 ma/ks/day WTmeEr Sex 1 2 Pu3pNumbe4r s 6 w casa03e w 33130 35.w 90 40.20 36.70 31.30 34.40 ca3376 3314/.2700 3341..4000 3335..6700 3392..9200 canazn sansa 3366..2400 3387..0000 3356..8700 3364..9600 saaarsd ann 2398..8400 3390..6500 27.00 37.00 63400 33521.4200 2359.9800 2373..3900 3320..6700 32.20 30.00 20.50 29.50 sans 3577175300 3365..5300 3367..5000 338..1200 caus 3480.73300 4308..0600 32891.3700 3367..3800 _ `Company Sanitized. Does not contaln TSCA CBI 3 H9-02-4D5a1y6:GavSaugbcehSrtoundicyTionnRiactistywith OneGeneration Reproductive Evaluations DuPont-5386 - Individual Pup LWeaicgthattsion(gDraayms)1: Fy Generation Group: VI-0 Dose: 100 mg/kg/day Sotpit Number mmm Geaesan up PupNumber Sex 12 3 4s awleso ws1lw20 43428 su3a39 sass sanaesa 3366..2100 3346..4400 3323..6700 34.50 33.60 3366.18400 3357..8000 38.70 34.80 32.50 38.80 305.12400 3386..4200 3319..4600 3309..8300 643339 sasama 33691.5100 3384..0200 3385.5900 3357..8100 43337 38.40 41.30 38.80 40.70 38.50 37.70 39.60 33.20 seas 3326.13200 26.10 35.30 30.20 - Company Sanitized. Doss not containTSCA CBI E23 H9-02:4D5a1y6:GaSvuabgcehrSotnuidcy iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont:5386 --- Individual Pup LWeaicgthattsion(gDraayms)1:4 Fy Generation Group: VI-0 bose: 100 mg/kg/day aMnaimmbaelr SPuepx 1 wer 2 uptu3sber. 4s eansn some saaez7 saaar0n sanaan 439 Geausat san sa3460 35.70 36.50 29.90 37.40 36.20 38.20 36.80 36.70 23311.5600 2374.14900 3370..3100 3342..3600 23001.3200 3342..3200 3314..1400 32.00 29.90 3368.13800 3385..0800 3450..7300 35.60 3323111400 3224..2900 3323..2500 3334..4500 - Company Sanitized. Doesnotcontain TSCACBI TI 9H0-2-4D5a1y6:GavSaugbcehSrtoundiycTionxRiactistywith One.Generation Reproductive Evaluations DuPont5386 --_ Individual Pup LWeaicgthattsion(gDraayms)1:8 Fi Generation Group: VITI-0 Dose: 1000 mg/kg/day aNnuimmbaelr sPeuxp 1 2 RupesN5aumkbeer a s Tw awsasno m24e20 3m0.w50 W23.a60 sasae3 3320020 aalo0o 33523500 3343e800 sa2a17 335400 2169..9600 22705.5900 2248..5200 suas 22855800 22s6i.00 2268.0600 2226..3300 ane s30i07e0 32.90800 3312.2000 u3s30o sess 2299006600 3271.3100 23010200 2269.5800 eaese 332605800 335020 233l0e0 3381700 se3e40 22s8i0s00 2256.9500 2296..0000 2390..7300 sesar08 sna --~ Company Sanitized. Does not contain TSCA CBI TI 9H-02-4D5a1y6G:aSvuabgcehSrtoundiyc TinoRxaictistwyithOneGenerationReproductiveEvaluations DuPont-5386 --~ Individual Pup WLeaicgthattsion(gDraayms)1:4 Fy Generation Group: VITI-0 Dose: 1000 mg/kg/day aWnonmbaer PSuepx 1 2 Bel3 es . s wm m30w0 ms0 mBlwo w38m0 sasses 23000000 2299.3000 2203..2300 26.90 26.30 sasarshl sansze aa3300n 2205.800 2276.400 226001400 2255.6200 seaaasd pre se24285 33s2.500 3363.600 3218.8800 3331.6300 serena -- Company Sanitized. Does not contain TSCA CBI 6 H9-02-4D5a1y6:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Genestion Reproductive Evaluations DuPont-5386 _ Individual Pup WLeaicgthattsion(gDraamys)2:1 Fy Generation Group: 11-0 Dose: 0 mg/kg/day soit WE Naber Sex 1 Pup Number 234 s we 43343 sans sansan S660.7500 6614..3000 6654..5000 5632..3700 7627.4000 6e7s.i8e00 969..1900 71.70 74.60 samo seaman 77205.03 7792.8000 7T7s.4o0 6713..2400 aanson ane 6675..6300 6681..3800 6665..3200 6723..0600 cane 62120 60l10 58.10 64.60 Ss.60 57.60 57.40 55.10 sanam 4si70 47.60 44.20 49.50 45.30 47.70 43.0 45.50 Company Sanitized. Doss not contain TSCACBI 7 `H9204-5D1a6y;GavSaugbcehSvtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 --~ Individual Pup WLeaicgthattsion(grDaamys):21 Fy Generation Group: 11-0 Dose: 0mg/kg/day oy BG Nmber Sex 1 EE Pup user 2 5 4s -- sans prey G6e2l.s5o0 6s2e..3s00 6663..3700 6630..7500 sano sanass ssn enna 5567..7200 6516..0000 5506..3200 57.40 58.20 S56i.2500 4535..5200 5478..5400 4564..5000 6656..5700 6514.3600 6630..1400 $9.60 67.20 caauar SSei.8c0 6520..6700 5576..5200 s59..4500 sa3a78 S60e8s0 s619..3000 6631.3500 5538..7500 sense GGi6l3t 367..7900 6606..6300 6538..0300 `Company Sanitized. Dossnotcontain TSCA CBI 8 9H0-2-4D5s1y6:GavSaugbcehSrtoundiycTionrRiactistywith One-Generaton Reproductive Evaluations DuPont:$386 --- Individual Pup WLeaicgthattsion(gDraamys)2:1 Fy Generation Grou: 1v-0 DOSE: 25 MG/KG/DAY smn Wh Naber Sex 1 PupNusber 2345 6 To T555718400 E625.5600 6645.2900 6617..4500 334 5620..0300 6621.5800 6516..3600 5683..5200 ee 7605..5200 6616..8500 763..8700 6638..3100 snes 55361.3800 55541.5600 5575..2700 5566..4300 43450 5S56..2400 5675..2400 53.80 52.70 55.10 54.50 sansaz 671.15700 6612.8100 6617..5800 6654..3500 ears 55421.3000 6533..0500 5568..8500 5692..1000 sanaisa sa3a18 6517..6000 3569..2300 5569..2400 60.20 59.90 sanszs &668..4700 6767..6900 7702..2300 7629..9000 ~ "smpany Sanitized. Does notcontainTSCA CBI 2 9H-02-4D5a1y6:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPo-5386 -- Individual Pup WLeaicgthattsion(grDaamys):21 Fy Generation Group: 1v-0 Dose: 25 ma/ks/day AMnmipmealr mE canon pSuxp 1 2 b pup3 yd umb4er 5&6 60.40 69.60 60.20 66.10 61.20 60.50 are seamen 4549.10500 5556..7600 5508..0200 4644..8300 sesas2 anand sanz 643400 Geass sanast 602..4500 6660..6300 6610..0900 6518..7300 56260.5000 6667..2000 62.90 63.80 4575..0600 4587.3000 5611..5100 4526..1500 4651..6000 6403..6500 5488..2300 4569..7500 5570..0500 5661..8400 5588..4800 6536..5000 56150 55.60 58.80 59.00 -- *mpany Sanilized.DoesnotcontainTSCACBI 0 9H02.4D5a1y6:GaSvuabgcehSrtoundiyeiTnoxRiactistywith OneGenerationReproductiveEvaluations DuPon5386 ~ Individusl Pup WLeaicgthattsion(grDaamys):21 Fy Generation Group: VI-0 Dose: 100 ma/ks/day aTneimra eukp 12ERN3sgsmbeer 4s wT Go.6500 6e50.5700 carson saraze e339 ans case cans cama an cans 4Se..0400 5567..2700 5584..7200 52.20 52.20 $603.14000 5616..4500 5553..1100 60.40 48.20 GG5i.i3300 6S00.2300 5696..7100 5663..3000 5553.14300 6s0a.l3g00 5567..6700 5556..8600 62.60 55.30 64.20 61.40 64.40 52.80 60.70 62.50 GSeill30 caso e230 59.90 --- Company Sanitized.Doesnotcontain TSCA CB r e massTe H r rere e 9H204D5a1y6:GavSaugbeehSrtonuidey iTnoxRiactistywith OneGeneration Reproductive Evaluations Dupont 5386 - Individual Pup wLeaicgthattsion(gDraayms)2:1 Fy Generation Group: VI-0 Dose: 100 ma/ka/day Mnoetra PSukp 1 EL 2 upg3ue 4s asra anne saan caaeron sas canes saauset ann sae60 1Go.01.800 $671..7300 5672..4800 6660..0400 3550.3200 030 4550..3300 se0 4586..0100 sie 5513..5400 55.80 46.20 48.90 51.60 49.30 S505.6000 3720 6661..6700 6450 6630..7100 64.50 5596..5100 S170 57.00 56.00 60.10 `Company Sanltized. Doos not contain TSCA C81 --_-- TE 9102-4D5a1y6:GavSaubgcehSrounidc iTnoxRitcistywithOGneeneration Reproductive Evaluations Dupont-5385 ~ Individual Pup WLeaicgthattsion(grDaamys):21 Fy Generation Group: vIII-0 Dose: 250 mg/kg/day T Mwmmieweernr fwep 1A E2 TupBet>musN berOR. S s sara iSSss3ld2ko0o aaemoiee sme0e so s1e3o0 380 pr cane Sealoo S30 sae0o els 00000 woo 2401..0300 ose ane D36i3s0 S50 seoaoe sea seszswo s3e8m0 ac sans snes DS5l0o0 D0 assesmo saa ssieosno sme 4sso2l0n sao sass fG(3l50o00 sseeeo dm smssoiomo 4as5ss.ll6so0e snuz0n carne - Company Sanitized. Doesnot contain TSCA CBI TeSe 9F-02-4D5a1y6:GavSaugbeehSvtonuidcy iTnoxRiactistywith OneGeneration Reproductive Evaluations DuPont-5386. -- Individual Pup WLeaicgthattsion(gDraayms)2:1 Fy Generation Group: VIII-0 Dose: 250 mg/kg/day pint NFuwembbeeerr anes Gaarshid sanz ceaneen " eSxor 2 Pup umber 3 as EE SS5lR40 S50.60 53.050 5H2.E20 33541.5700 4437..8200 462..5500 44.00 43.60 13561.5600 4379..5700 4451..6000 4430..4400 sunnust aa34a9 6434293 452.040 s53e.l2400 6504.3400 5551.5700 reves -~ Company Sanitized. Dogsnot contain TSCA CBI J C2 ------------ H-24516: Subchronic Tovicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont-5386 APPENDIX HH REPRODUCTIVE TOXICOLOGY INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F; GENERATION - Company Sanitized. Doesnotcontain TSCA CBI - ms 9204-5D1a6y:GavSaugbcehSrtoundiyc TinoxRiactistywith One.Generation Reproducive Evaluations DuPont 5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION EXPLANATORY NOTES Footnotes a Nolive pups bom = Company Sanitized. Does notcontain TSCA CBI I: H-24516: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont-5386 --- INDIVIDUAL LITTER CLINICAL OBSERVATIONS: P, GENERATION GROUP: 11-0 DOSE: 0 MG/KG/DAY WAoNMIBMEARL LACTDAAYTION INsCIaDxENCE OBSERVATIONS 643343 643459 sa3a80 643363 643397 sa3a21 sa3a19 43401 sa3ass 543378 43347 - 43478 43386 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - CompanySanitized. Doesnotcontain TSCACBI - 910.2-4D5a1y6:GavSaugbechSrtoundiy iTnoxRiactistywith One-GenerstionReproductiveEvaluations Dupont 386 ~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION AMNBIMEARL LACTDAATYION GROUP: IV-0 DOSE: 25 MG/KG/DAY INsCiIoDnENCE oBSERVATIONS 643399 43334 ere 43269 s42430 643342 sasa20 se3a10 seaazs S447 643376 = sa3a52 se3475 e337 s43400 sa30s seas NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED XO ABNORMALITIES DETECTED Yo ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Yo ABNORMALITIES DETECTED Yo ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Yo ABNORMALITIES DETECTED Yo ABNORMALITIES DETECTED -~ Sompany Saniized. Does notcontain TSCA Cat ------------------ 9H0.-24D5a1y6G:avSaugbechSroundiyc iTnoxRiactistywith OnGeeneration Reproductive Evalations Dupont-5386 ~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: 7) GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NAOVNIBNELR LACDTAAYTION INSCIIGDNENCE OBSERVATIONS 643320 sesazs 03439 603353 643339 643337 02416 s03407 sana s43427 seen - 643349 03333 sa3460 HO ABNORMALITIES DETECTED HO ABNORMALITIES DETECTED HO ABNORMALITIES DETECTED XO ABNORMALITIES DETECTED O ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED XO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED = "ompany Sanitized. Doosnolcontain TSCA CBI --_---------- H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with OneGenertion Reproductive Evaluations DuPont 5386 -- INDIVIDUAL LITTER CLINICAL OBSERVATIONS: P; GENERATION GROUP: VITI-0 DOSE: 250 MG/KG/DAY NAoNMIEMEARL LACTDAAYTION INsCtIaDnENCE OBSERVATIONS 643467 NO ABNORMALITIES DETECTED 643833 NO ABNORMALITIES DETECTED 643317 DAY 21 23 0O0F 88 wDIESACKHARGE NOSE BLACK LITTER SUMMARY: 32 DWEIRSKC.HARGE NOSE DAY 21 PUP DATA: PUaP: DISCHARGE NOSE BLACK b WDEIASKC.HARGE NOSE BLACK WDEIASKC.HARGE NOSE BLACK 43413 NO ABNORMALITIES DETECTED 43020 NO ABNORMALITIES DETECTED - 643335 NO ABNORMALITIES DETECTED sa3a6e NO ABNORMALITIES DETECTED sa3a40 NO ABNORMALITIES DETECTED 43326 NO ABNORMALITIES DETECTED sa3365 NO ABNORMALITIES DETECTED 43275 NO ABNORMALITIES DETECTED sa3328 HO ASNORMALITIES DETECTED preres NO ABNORMALITIES DETECTED sa3a208 CompanySanitized. Doesnotcontain TSCA CBY --- mw 012-4D5a1y6:GavSaugbeehSvtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont 5386 APPENDIX II REPRODUCTIVE TOXICOLOGY -- INDIVIDUAL BODY WEIGHTS: F; GENERATION --- `Company Sanitized. Does not contain TSCACB ww H-24516: Subehronic Toxicity '90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: F, GENERATION EXPLANATORY NOTES Notes Dayofweaning = Test Day | a No data due to weighing error. DuPont5386 = `Company Sanilized. Does not contain TSCACBY = --- H-24516: Subehronie Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont-5386 -- INDIVIDUAL BODY WEIGHTS (grams) OF F, MALE RATS GRovR: 1-1 DOSE: 0 MG/KG/DAY onDTaEvSsT: ANIMAL NUMBER 654477006689 64477007710 864477007732 554477007753 554477007767 54477007789 47080 1 5 1s 2 29 36 s62l.s7 110332.022 1205760.85 220749.50 23521..77 43013.79 7233062 113w0s0l1o 21s020l1s 224684.28 331306.72 333:63.86 s4a5i'ss sslalo7 i1smelso 221433057 236075..86 332657..30 6S3e0l7l 0s7el2s 117s6a17s 2251050.09 3225871.43 332134.33 6Sa2lo aisa3lls7 117s93lls0 221s803s 2218920126 236864.75 5s9e.l7s 0915.12 1s6e7l.s6 222207.37 2370321.s6 33295.a9 6300 10900 1623 227.5 285.8 302.2 `CompanySanitized.Dossnot contain TSCA CBI ms -- 2H90-0-2-D4D5aa1yy6G:GaavvSaaugbgeceShrStotunudidycyTiionnrRiRacatitstsywwiitthhOOnnee-GGeenneerartaitoonnRReepprroodduuccttiivvee EEvvaalluuaattiioonnss DDuuPPoomntt:-55338866. ~ INDIVIDUAL BODY WEIGHTS (grams) OF Fy NALE RATS Grove: 111-1 DOSE: 25 MG/KG/DAY onoaTressT: ANIMAL NUMBER s6a7n112z4a 4477112256 s4a77112267 a77113209 8477113312 654477113331 s4a77113365 s64a7m133s7 1 s 15 22 2 36 6673.25 110086l.s2 1177261.24 223360..48 230021..66 343-.a9 6Se8l1a 1s073l1s3 s1esellss 22113520 227786..24 333064..78 GS8a1l1s 01035'7s 116636..75 223225083 229407.02 334461.24 s602l020 1100271021 116e78.l0s 223347.s8 226903..13 238633.85 77200059 112320018 118776.l50 221321.04 321898..27 338431.s2 664137 1100881137 e1s7iss 223214047 2300085s 337062..15 462418 1m03314 1nseallsa 212m51 222725022 321716.s8 6s3a1iss 1s0s8l22 u16s5.0 220270..34 227621..85 332345..00 ompany Sanitized. Doesnotcontain TSCACBI EE 20H---D2D4aa5y1y6G:GauSvauabggceehSrSoutnudidcyTIioonxRRiacatisstwywiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveePEvvaalluusattiioonnss ______ DDuuPPoonn-t55338866 --- INDIVIDUAL BODY WEIGHTS (grams) OF Fy MALE RATS -_-- GROVR: v-1 DOSE: 100 MG/KG/DAY onaTvEsST: 1 ANIMAL NOMBER 5 1s 2 20 36 477118854 554477118867 ssaa77118a8s 6a6477113910 45477119923 ssaa77119945 5620..15 asl ssasiss 115s1o.l80 221172.156 227694..54 22796..26 sis 153 200s 232.7 sen 6S661.36 607 1s1e4l4s 106ls 11811s3 16817 2224061 23102 330125..25 267.4 33850..57 295.1 5696..90 0ssllos 11s7s5l1s 223273036 227050..27 330080..15 s5s3s4 ssaelidn 115570.77 222150013 228764.07 330000..12 5693..67 1s0l6s7 117630s0 222235.142 228830..57 331134..45 Company Sanilized. DosnotcontainTSCA CBI ws 00H--2D4Da5ay1y6G:GaavvSaauggbecehSSvtuounddiyycIiTnnoRxRaiatctsistwywiitthhOOnnee- GGeenneerraattiioonnRReepprroodduuccttiivvee BEvvaalluuasttiioonnss _________DDuuPPoonnt-55338866 ~ INDIVIDUAL BODY WEIGHTS (grams) OF Fy MALE RATS GROUP: VII-1 DOSE: 250 MG/KG/DAY onDTaEsST: ANIMAL NUMBER 64477223310 4477223323 64477223350 64477223376 664477223389 6s4a77224401 1 5 15 2 20 36 4a2.36 89.6135 1a3l7.s5 2a0n0l.s2 a2s:s2e7s 33118.s3 ssollos ss2ell17 117300lss 219274.03 325424.62 421870..05 5500077 5204 ssesllas s1eal3lss 220201017 228851.35 22795..50 87.3 18313 20901 239.0 318.9 aslisz ssaailse 11331lsa 2115000095 224320.88 226959..35 44601a5 sso0lls3 1313s1lss 120827000 227a0..4 32717.37 557 000s 155s 21403 za6.2 327.4 ----------t---------- 3 ----Co--mpa-- ny Sa-- nitiz-- ed. D-- oes-- not c-- ontai-- n TSCA CBI 9H0-2-4D5a1y6:GavSaugbcehSrtoundiycTionxRiactistywithOneGeneration Reproductive Evaluations DuPonc5386 -- -_-- INDIVIDUAL BODY WEIGHTS (grams) OF F, FEMALE RATS Grove: 11-1 DOSE: 0 MG/KG/DAY onDasyss: 1 ANIMAL NUMBER . 15 22 25 36 6s4a77227787 45477227890 sa477228621 54477226603 554477228856 66a4r7z20687 Gar209 5529..13 67.4 19063.10 1038 113309.035 131s 1l5e60.l9s 1522 117872..17 170.8 220001.44 175.7 5652..10 45.9 99691046 si 114438.171 1203 11e850..5s 16303 120949.87 1927 2a1291.4e 23g 050..53 ds 983520 7eln 11232910s3 13107 11759802s Isso 21071373 176. 220105..96 1s.0 8538..14 58.5 10e2s.i2s 540 11:50613 13500 e1sailss 167.0 221107..27 1s46 1a1lloe 10 58.3 ols 12603 102 let i767 = - Company Sanitized. Dos not contain TSCA CBI mm H9-02.4D5a1y6:GaSvuabgcehrSotnuidcyTionrRiactistywith One-Generation Reproductive Evaluations Dupont-5386 --~ TNDIVIDUAL BODY WEIGHTS (grams) OF F, FEMALE RATS GROUP: 1V-1 DOSE: 25 MG/KG/DAY onDTaeyssT: ANIMAL NUMBER 4477332276 477332298 664477333301 46477333323 564477333354 54477333367 64477333389 64477330410 ar302 1 5 15 22 2 36 5618.54 9971.70 11833..69 11s6e1..54 2s04e.3 223-.a5 5s63.l3s 9ss6l.0 113a76.z7 l1e8s1s1 129025..18 220268..55 5sasll5 150260l1s 11s1el0a 127162..93 224060.14 222833..29 s5e9l.19 s55e.l4l 1lass0.ls 113s60..40 212933..64 224023..17 Sso0l5o 10080l0s3 la10mlls7 2l2e021.4s 21372.37 219870.77 asesa 7975.165 113174.88 113m7l39 114965..58 212624..79 seelos 8s7s.l9o 1127410 115m5l.s7 127040.77 129168..81 4sselo7 ssells? 1122300036 1155101s 118702..41 119962..27 sso s7ls 10a esis 1961 219.3 ~~ "ompany Sanitized. Does not contain TSCA CBI mm --- 1902-4D5a1y6:GavSaugbeevSotnudiyeiTnoxRiactistywith OneGeneration Reproductive Evaluations DuPont-5386 -- INDIVIDUAL 20DY WEIGHTS (grams) OF , FEMALE RATS Group: vi-1 DOSE: 100 MG/KG/DAY onoTresst: Ana woNEER s5447733955 s6i477339976 sii7733998 si&sr4a7raaic0o20n siGir7aio0d Garios i s is 2 2 5 6sa.i7 $31 1e0e1lss sols 11335025 als 1de7es deal 115ma aslo misz oes sslsos e205 sseis eso moalsiss 1422 m1las iss a16l70s7 ws adseina ase SGsei4as sseerrlsss 1ma2ll0ss0 d1G7e07e32z z210e0sas saa1msssi3 #s9e3 61 meeilss sels aamriis alo waaslle amlo Ilsalss 1s 1176a 9 zis _ - Sompany Sanitized. Doss not contain TSCA CBI ww 910.-24D5a1y6G:ovSaugbeehSrtoundiycTionxRiactistywith One.Generation Reproductive Evaluations DuPont5386 INDIVIDUAL B0DY WEIGHTS (grams) OF F, FEMALE RATS ---- eee-- Grove: v-- izeIc-1 --DOS-- E: 250 H-- O/Ka/DRYmt owoasresr: : . 1s 2 2 3 Anos vosen GasGraarireze3ee7 8Sfi4ir7i4ii3o0 SCpiaroiess SSSiie7rr0ieaers 2s5904057 9aG7si2 I1amlaa e1d0ezan aaistsooss 21e9a7s 3Ws5is5sa 77oeelllse im1mlnss eddeahlna liiwsooee a3s0i5se0 a$2sll2o ree0alssz a1dmiaye 1IIm8sia9 dd1em3ala4s dsseaielsorns aGSllse emselhles allsamads 1lmmelas adeomersn ssieieeaee Company Sanitized. Donotecontsain TSCACB wm H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5386 APPENDIX JI REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: F; GENERATION -- `Company Sanitized. Doesnot contain TSCA CBI -- RP i------ 9H-02D4a51y6:GavSaugbcehSrtoundiyc TinorRiactistywith One.Generation Reproducive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: F, GENERATION EXPLANATORY NOTES Notes Dayofweaning = Test Day 1 a No data due to weighing error. DuPone-5385 -- mpany Sanitized. Does not contain TSCA CBI EE 9H-02-4D5a1y6G:avSaugbeehSrtoundiyciTnorRiactistwyith One-Generation Reprodcive Evaluations DuPont5386 _-- onaTvesst: ANIMAL NUMBER sa477006689 64377007710 854477007732 664a77007705 64477007767 54477007758 647080 TNDIVIDUAL BODY WEIGHT Group: 1-1 1-8 seis 4507..65 S15153s 456.85 smiilos @50s.24 6el6s8 4430..58 esszs 4379.027 esssils3 435055 eesliss 6.0 S33 GAINS (grams) OF 7) MALE DOSE: 0 MG/KG/DAY 15-22 22:29 29036 manys manag sss2o2 ee3s0o1 e7l2lsa 1a6l4s 657107 esai3s s5a3l2e 6m1l2s aslaa ae1so e7s0i0s s32o0l0s 8s3iss essesn amslss 253.35 esa sels ted RATS 1-36 a2m;a2 26503.24 a30r2e.s4 2s6o5l.e2 2203900037 22s69i6s.2 2393 -- >mpany Sanitized. Does notcontain TSCA CBI -YY Tm 9H0-2-4D5a1y6:GavSaugbeehSvtoundiyc iTnoxRaitcstywith One-Generaion Reproductive Evaluations DuPon5386 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF , MALE RATS --_-- Rove: 111-1 DOSE: 25 MG/KG/DAY onoTaEtSsT: 18 sas 15-22 229 2936 1-36 ANTAL NOMBER ssaann2ze 664477112256 saamn227e ssaa7n123s0 ssaa7m13a2 p4r71e33 ssaa771133s6 6caamn3e7 435837 3s 7e0l2 ssls seialaz sia 7s0e.z8 eslo eaa 20a0.7 263 2364 a45z.4 412 ssese3ll0oz0 s5sl33 esis esraad 147 ssoelza 329e00033 saz 276.7 4460025 4319 c6iallas 647 6e7s.o8 sas 2s5s3s 76s 270as adoasse eso 3l0.s 442020 470 e61l2s 61 sseslos sls sseanz 76s s2s:a0 227308..62 ers 3144 33062 387 s6l1s0 491s es3all0? e2l2 ssoolns sels 3si2e7 224314071 21 zeals 447 sels ssa 52.4 eels ansie EE .ompany Sanitized. Dass not contain TSCA CBI 0H--2D4a51y6:GavSaugbcehrSotnuidcyTionnRiactistywithOneGeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL S0DY WEIGHT GAINS (grams) OF Fy MALE RATS ----------Ro-- we: -- v-1 ------ DOSE:--10-- 0 MG-- /KG/D-- AY -------- onaTyessT: 18 as 15-22 22-29 2936 1-36 ANIMAL NUMBER s6a4n71188a5 ssaan7118876 saan71e8s9 6s4a7n119901 s4a7n1s9z3 s4a77119954 w309l.71 5521.22 6e5l.s8 4e6s.s8 1182..72 2a16e.1 aallle essaiiss ee3s0l32 2790.52 276.42 231160..45 4425.82 es2lls2 es3llss 3e6i2 733137 2e3l4s 43a28300l71s 6es0ils5 ells ecaalss 616 53774s eld 22090.23 22345110 13.5 46.8 s3l8o6 6se0l3s sseelas e6s3.s 226417 224449.039 49i2 eal s2l2 sal7 30.6 254.9 --- _-- _ompany Sanilized. Does not contain TSCACEL TE 2H90-0:2--4DD5aa1yy6G:GaavvSaauggbeeeShStrtouunddiyycTiionnxRRiaacttisstwywiitthhOOGnneeenGeerneartatiioonnRReepprroodduuccttiivvee EEvvaalluuaattiioonnss DDuuPPoonntt-55338866. -- INDIVIDUAL BODY WEIGHT GAINS (grams) OF F; MALE RATS r--r ------------G--ROU--P: --VII---1--------D--OSE--: 2--50--MG--/KG--/DA--Y ------------ onDTAEYSST: 1 seas 15-22 22-29 29-3 1-36 ANIMAL NOMBER s4a77223310 47232 4s3o.z7 s51320 e657740 sesoss s59e.s2 225905..67 s67 m1 sls 12006 72.4 370 4477223334 47235 4a537 es7llds se32l37 sseolzs 21850.76 224460.02 34s ssa s72 sae sis 224s 4477223376 647238 3ssllao 336 sssslns ass mesliss ssn aaslss asia s3a2l5a igeelss san ass 664477224309 47241 33370.81 ssasiss es3slas asseilal ea2l5z3 22361s.25 asiz sels sels oils ma 271 - ompany Sanitized. Does notcontain TSCA CBI wm 9H0--24D5a1y6G;aSvuabgcehrSotnuidcy iTnorRiactistywithOne Generation Reproducive Evaluations DuPont-5386 -- INDIVIDUAL 50DY WEIGHT GAINS (grams) OF F, FEMALE RATS Group: 111 DOSE: 0 MG/KG/DAY onDaTyess: ANTAL NUMBER 1 sas 1522 22.29 29-3 1-36 c4a7r227778 46477227890 si64r7z20012 6s4a7r226834 s4a77228865 c4a77228887 car28s a36l.o7 3e4l3s 2263.6 22012s 126837 l142e0 a 3a6l0e4 3aa0 13s67 l1a9sa a5es 1as2s0i3s a3832 47sl2 a3l1s0 2la9s4 120s1 elseisas 332707 4a6l7s 33s9l77 2s8o1 217ss 1isselo1 3326a a43llee a33.a3 2el1s8 a1za leelass a3lss salalzo 2230004 32710s6 119031 smslss 31 sls mls mls 1s aes o~ - sompany Sanitized. Doss not contain TSCACEU wm H9-02-4D5a1y6G:avSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 _ INDIVIDUAL BODY WEIGHT GAINS (grams) OF F, FEMALE RATS Grove: 1v-1 DOSE: 25 MG/KG/DAY onoTaEvSsT: ANIMAL NUMBER 1-8 sds 15-22 22:29 29-36 1-36 64477332267 64477332289 653477333301 564477333323 64477333345 54477333376 64477333389 46477333801 47332 33801.53 4d6l.s5 2a2l8s 214874 -18a.6 165a.0 33891037 lsols2 malas 2z3e37 114847 4173262 3a7l0d6 ssllss ssslls 23a02 23271s 21618.s7 33990050 s52l78 aasss 2n7la2 1l2e3s 118433.80 3l90s8 sso2lls9 a22s00 1s1lsa d2e6e0 1231710.27 3327008 a332 23as 2s3isz s26l.a5 1le2a001 33200 338611 a3187 2198080 1272.14 1154101 33200087 e3sllis 22s7l0ss 229136 21s0.06 1160..02 ls axis 270s 21s 232 160.3 - - = `Company Sanitized. Doesnotcontain TSCA CBI 2H9-202-4D85a1y6D:GoaSvvuaabggeeehSrStotunudidycyTIionnxRiRacatitstsywwiitthhOOnnee-GGeenneerartaiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt-5$338866. _ -_-- INDIVIDUAL 20DY WEIGHT GAINS (grams) OF F, FEMALE RATS GRouR: VI-1 DOSE: 100 MG/KG/DAY onaTesst: ANIMAL NUMBER 1-8 sas 15-22 22-29 29-36 1-36 654477339954 664477339976 477339998 64477430010 564477440023 564477440058 3366.80 372 a4asl1za 2361s0 320s 2220570..548 220100 1e30s2 as 153.7 43020035 215 aallea sez 3358032 421 3s3l7s 25s 2266a3 11ss0l0 asa aml 7322.2 361 4ssllsz 432 ssallaa 390s 22871s sols 2174.94 116a0i 1s erie 22000025 381 33990s3 wales 23a8l2s 3200 211778 253 115319 a1o4l4 246 sale - Company Sanitized. Does not contain TSCA CBI wo `3910.0:2DD4a5a1yy6GG:aavvSaauggbeceShSrttouunddiyyciiTnnoRRxiacstistwwyiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonnt--55338866. - INDIVIDUAL 50DY WEIGHT GAINS (grams) OF F, FEMALE RATS Grove: vizz-i DOSE: 250 MG/KG/DAY onoaTersst: mas, women 18 eds 1s: 2229 2903 136 sSaa7raa3z7e SsEaii77ra4a33as9o ppriioons pSraroasa GGaarraassse Sarasr 3de8l.s8 tz esalss oasis a321s aes 2da3la aaa 6a2 1ismis aris 2304 3s0e5es 3a a4r2iss usr a3z0o1 das 2sl7s ars s2salh0 siemo 134 ies 332022 327 aaaos a2 332s8 2007 2de6ls ea 2z4e 1daei 33 ise s3i3s Blo asoslss ass ddaalies als aa4i a0 3a074 idnesles os aris - Company Sanitized. Doss not contain TSCA CB wm -- 9H02-4D5a1y6G:avSaugn bechSrtoundiycTionn xRiactistywith Onnee-CGeeneerratioonnRReepprroodduuccttiivveeBEavaaltuaitoionnss DDuubPoonnets-533g866. APPENDIX KK REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: F, GENERATION -- - Company Sanitized. Doesnotcontain TSCA CBI mm 9H0-2-4D5a1y6:GavSaugbeehSvtoundiyc TinoxRiactistwyith One.Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: F, GENERATION EXPLANATORY NOTES Notes Dayof weaning = Test Day 1 DuPont5386 = Company Sanitized. DoesnotcontainTSCA CBI mw 5H-02-4D5a1y6:GaSvuabgcehrSotnuidyc TinoxRiacistywith One.Generation Reproductive Evaluations DuPont5386 -- INDIVIDUAL FOOD CONSUMPTION(grams/day) BY Fy MALE RATS Rove: 1-1 DOSE: 0 MG/KG/DAY onDATEYSST: ANTAL NOMBER s4a77006698 a4r70o7m0 sa477007723 6s4a77007758 564477007767 54477007785 647080 18 81s 15-22 22.29 29-36 1-36 1125.23 220058 22034 23.093 255.26 2a0l3o 110237 2200 2280011 236a7 2z6e1a a2:s2 1124s 120 2e0l0s0 2006 2233036 25.1 2za61 303 1s0l2s as 1182s m0 i1l2o7 11827 22221057 22310as m1238 21026 11230s s20l0s3 223s1l7s a2s5s0 s30l5 2222ss i1z0l1e eslleo 223e018 2297s0 226s2. a2ias - `Company Sanitized. Doos not contain TSCA CBY ws 0H--2D4a51y6:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Genertion Reproductive Evalutions Dupon5386 _ INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fy MALE RATS Grove: 111-1 DOSE: 25 MG/KG/DAY onoaTEtSsT: ANIMAL NUMBER Gsiannzaa seai7r11226s ssi7n12r8 ssiirn112390 ssaannaz esa771m33s sii7m336s ssearriias 18 sas 152 229 2936 136 1a.l5s nl 1a9l.e4 aslo 22.5 als 22a67 aslo a2sess ase 2as1. 0a mnlles Bz waszh 192 aallay 2s asslss ze a7s. asl iisnsa as 13232 183 120913 204 a2e4ss 2500 22aa 288 aml1s aes 233047 234 1n2l2s Wi ssllss mz 2ai0l0s als am3z7s oaamsiss laa 2i0e3s aa nsllsa wis 1sslis1 ss s19lso 20ls 2as2isa 228 aaasssaaa siisalals lo aslo 2lz zan iss aa = \ompany Sanitized. Doosnotcontain TSCA CBI ----e-- e T-- oe -- -- --e -- e 29H0-22-4DD5a1y6D:GaavvSaauggbeecShStotunudidycyiiTnnoRxRaiatctisswtwyiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonnt-t55338866. -_-- INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fy MALE RATS Grove: v-1 DOSE: 100 MG/KG/DAY onDTaEsST: ANTAL NUMBER 1-8 eas 15-22 22-23 29036 136 sasar7i1s04 46477118867 ssaa77118889 54477119510 s4a77119532 6477119950 07le 9.6 1as6ss 17.4 224147 als 229s4 2600 228a7 2s 2i1ssa 203 11230.07 1204 2200l0ss 20s 2e6l.o2 ass 2390023 261 1157.74 27.2 22015s 22s m12i0s9 1 120l06 ela 2as4i7a 2404 z2e6a2 290s 2285.24 246 s22i0e0 sie mm36 15.6 a1a7 212 a2l3s3 220s 226023 24s 224682 28s 2a0a3 ale -- EE Company Sanitized. Does not contain TSCA CBI 0H-24D5a1y6:GavSaugbeehSrtoundiy iTnoxRiactistywithOne.Generation Reproductive Evshations DuPon5386 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F, MALE RATS Grove: vI1-1 DOSE: 250 MG/KG/DAY onoaTvesst ANAL wovsER 8Ga477223310 s6i477223323 sea472ar3s sssaia777223333786 s6a477221309 sanz 18 eas 15-22 22.29 203 136 112l.s0is 1as8l0o ala 2l3.a4 alr 236s0 als 240s aa aiess iss 01250s 1003 1Is6lss es aa0slisa ans 2aaan aaa aslaoe 3s 12a 154 i11ml0o3 aaarlzss aaalllays aaalcneo s3aahsn 0 zaolns n01a 2s 1as6l2y als 2mlz0013a 3a 3: essa seo 0is4 2008 - --- Company Sanitized. Does not contain TSCA CBI ws 9102-4D5a1y6:GaSvuabgcehrSotnuidcy iTnorRiactistywith One-Generaion Reproductive Evaluations DuPoni-5386 IUDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fy FEMALE RATS GROUP: Tr-1 DOSE: 0 MG/KG/DAY onoaTtess: ANTHAL NUMBER 18 sas 15-22 2229 20-36 1-36 sasir7227778 64477227009 ssaar722s021 4477228834 sa477228865 scaarr228878 e428 1122.s1 az 116h1 sls a18e6s 154 118a5 14s 11795 15a 1le7.0 las uills s1l6ss 1slss 1ar8s7 1178ss s16os l1o4ls 11663s 210071 2180s 1188ss e17s2 1s2lss ssllsa 1a779 11627 11774 aassss uBliez 2s0l0ss 118835 2200063 210748 116s anllea asiez 1167073 116s0 11535 aiees = --- Company Sanitized. Does not contain TSCA CBI ww 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnorRiactistywith OneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F, FEMALE RATS GRovP: TV-1 DOSE: 25 MG/KG/DAY onDTAEYSST: ANIMAL NOMBER 1-8 ses 15-22 2229 2936 1-36 64477332267 12s0s8 1166lss a1s.3l 117.83 4169..84 2171.64 s4a77332289 1120s2 eelzs sllas w19a07 2m024 11763d 64477333310 sana32 l1o3l3s oaassils 123813 12e02 o1assis 1a163 us ala 2a als m7 19s 654477333343 1122533 210621 21734 212639 a1r4e7 2is1i0s 664477333356 1s3l1o m13l0z7 11a2ls 1142a iesois 1163ss 6477333378 sa7339 m10l0ss a1r6i3n e17l0s3 210a2 212735 1is8l3e 1007 14s sls sls isa 1407 477330001 47342 0100028 11s5l1a 1oa6si3s 1166ss 111626 115s.0 nls 167 wo ls 1a lez ~ Company Sanitizad. Dossnotcontain TSCA CBI we 9F-02-4D5a1y6G:avSaugbeehSrtonuidcy TinoxRiacistywith One-Generaton Reproductive Evaluations DuPont 5386 --- INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F, FEMALE RATS GRoUR: vI-1 DOSE: 100 MG/KG/DAY onDTaEsST: ANIMAL NUMBER 1-8 seas 15-22 2229 29-36 1-36 G4a77339950 554477339976 46377339985 64477440010 64477430023 564477440085 mm74 116537 a6lsr 116880 1179.47 11s6s 10017 e1l3s 1l90o8 1196s1 a1s6s0 147.84 1720ss 1186l03 1188lss 2m0i0 1auss 117s5 n1l0ss Bi 1167a 162 1199s7 19le 2109003s 1907 1290027 19ls a138 177 s5.a4 1oassis sellss 11s7s 117sa. 11s44 wr sla 200s als 205 187 ee --e ------------ Comp-- any Sanit-- ized. Does-- notcontain TSCA CBI 6 9H0-2-4D5a1y6:GavSaugbechSotnuidcy TinonRiactistywith One.Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F, FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY onDTAEYSST: ANIMAL NUMBER 1-8 eas as-22 22-29 2936 1-36 s4a774a3376 1122i0s 11s7l77 1186s 1s9l.s8 116452 1166.09 4477443389 09072 ualss aesles s1l7ss i1s9la 1asia6s 64477444010 0s0l2s aaslisn aasles a1r9ilsa 11378s lasiaes 664477444432 wsiles 160ls 2 172 1m0a 11805 a1sia5s 6a477a4a4s4 nsllss eallss 11260a0 1s6l7s 1198036 i1si7s s6a477a4a467 1s2l2o s1l8ss salsss 1290000s 210725 1176.97 `Company Sanilized. Does not contain TSCA CBI EE 9H-02-4D5a1y6:GavSaugbcehSvtoundiyciTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont 5386 APPENDIX LL REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS: F; GENERATION - "omeany Sanitzed. Doss not contain Tsca cay mm H24516: Subchvonic Toxicity 0-Day Gavage Study in Ras with One-Generaton Reproductive Evaluations _ REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS: F, GENERATION EXPLANATORY NOTES Notes Dayofweaning = Test Day | --_--_-- "ompany Saniized. Does not contain TSCA CBI 2904-5D1a6y:GaSvuabgeehvSoundiyc iTnoxRiactistywith One Generation Reproductive Evaluations DuPont 5386 --- INDIVIDUAL CLINICAL OBSERVATIONS IN Fy MALE RATS Group: 1-1 oose: o wa/a/ony ANAL wenER cassruaTion CFromssetRoDv aosmtszaovaErD 647065 PSRAECPRUITFIIACLEDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 1 1 647069 PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 1 1 647070 SPARCERUITFIIACLEDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 1 1 64707 SPARCERPIUFTIICAELDSEBYPADREASTIIGONN TCEOSMTPLDEATYE 40 20 20 47072 PSRAECPRUITFIIACLEDSBEYPARDAETSIIOGNN CTOENSPTLEDTREY 40 47073 PSRAECPRUITFIIACLEDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 1 1 1 1 647074 ESRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 1 1 - 647075 SPARCERPIUFTIICAELDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 1 1 647076 PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN TCEoSMTPLDEATYE 40 20 20 647077 SPRAECPRUITFIIACLEDSEBPYARDAETSIIOGNN CTOEMSPTLEDTAEY 40 20 20 64707 PSRAECPRUITFIIACLEDSBEYPARDAETSIIOGNN CTEoSMTPLDEATY 40 20 20 647079 PSRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 647080 SPARCERPIUFTIICAELDSEBYPADREASTIIGONN CTEOSMTPLEDTAEY 40 27 = 2 20 - Company Sanfized. Does nol contain TSCA CBI = --- H9-02-4D5a1y6:GavSaugbcehSrtonuidcy TinoxRiaciistywithOneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL CLINICAL OBSERVATIONS INF MALE RATS GROUP: III-L DOSE: 25 MG/KG/DAY ANIMAL BER oasgRuATION OFBISRESRTVEDDAY OLBASSETRVDEADY. amas SPRAECPRUITFIIACLEDSEBPYARDAETSIIOGNN TCEOSMTPLEDTAEY 40 14 1 47124 PSARCERPIUFTIICAELDSEBPYARDAETSIIOGNN CTOESMTPLEDTAEY 40 20 20 san125 SPARCERPIUFTIICALEDSBEYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 2 2 samze SPRAECPRUITFIIACLEDSEBPYARDAETSIIOGNN TCEOSMTPLEDATYE 40 2 2 san127 SPARCERPIUFTIICAELDSEBYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 2 2 san128 SPARCERPIUFTIICALEDSEBYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 2 22 camas PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN TCEOSMTPLEDTAEY 40 20 20 - 47130 PSARCERPIUFTIICAELDSEBPYARDAETSIIOGNN TCEOSMTPLEDTAEY 40 2 2 sam31 SPARCERPIUFTIICALEDSBEYPARDAETSIIOGNN CTOEMSTPLEDTAEY 40 2 2 sanz SPARCERPIUFTIICALEDSEBYPADREASTIIGONN TCEOSMTPLEDTAEY 40 2 2 7133 SPARCERPIUFTIICAELDSEBPYARDAETSIIOGNN TCOEMSPTLEDTAEY 40 22 = san13a SPARCERPIUFTIICALEDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 20 20 sass SPARCERPIUFTIICALEDSEBYPADREASTIIGONN TCEOSMTPLEDATYE 40 20 20 cams PSARCERPIUFTIICAELDSEBPYARDAETSIIOGNN TCOEMSPTLEDTAEY 40 2 2 647137 SPRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN TCOEMSPTLEDTAEY 40 26 2 san138 SPARCERPIUFTIICALEDSBEYPADREASTIIGONN TCEOSMTPLEDTAEY 40 22 2 Company Saniized. Does not contain TSCA CBI wm 2H0--24D5a1y6G:avSaugbcehSrtoundiycTionxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 = INDIVIDUAL CLINICAL OBSERVATIONS INP, KALE RATS GROUP: V-1 DOSE: 100 MG/KG/DAY ANTAL NOMBER oasgRvATION OPIBRSSETRVEDDAY 1OBaSSETRVoEYD anes SPARCERPIUFTIICAELDSEBYPADREASTIIGONN TCEOSMTPLEDTAEY 40 20 20 san185 SPARCERPIUFTIICAELDSEBYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 25 25 anise PSRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 25 29 pre SPARCERPIUFTIICALEDSEBYPADREASTIIGONN TCEOSMTPLEDTAEY 40 20 20 caren PSRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 23 2 sa7189 SPRAECPRUITFIIACLEDSBEYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 22 2 47190 SPARCERPIUFTIICALEDSEBYPADREASTIIGONN TCEOMSPTLEDTAEY 40 27 Ed - sano SPARCERPIUFTIIACLEDSBEYPADREASTIIGONN TCEOSMTPLEDTAEY 40 20 20 47192 SPRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 23 = san193 PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 2 27 pen SPARCERPIUFTIIACLEDSEBYPADREASTIIGONN TCEOSMTPLEDTAEY 40 20 20 47195 SPARCERPIUFTIIACLEDSBEYPADREASTIIGONN TCOEMSPTLEDTAEY 40 22 2 Pe - Company Saniized. Does not contain TSCA CBI wm 2-9H0D--2a4D5ay1y6GG:aavvSaauggbeeehSSrttouunddiyyciTionnxRRiaacttisstywwiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivvee EEvvaalluuaattiioonnss - INDIVIDUAL CLINICAL OBSERVATIONS IN Fy MALE RATS GROUP: VII-i DOSE: 250 MG/KG/DAY DDuuPPoonntt-55338866. ANIMAL NUMBER ossERvATION FOIBRSSETRVEDDAY O1BaSSETRVDEADY 47230 SPARCERFIUFTIICALEDSBEYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 san231 PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTEOSMTPLEDTAEY 40 47232 SPARCERPIUFTIICALEDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 2 2 2 2 20 20 47233 SPRAECPRUITFIIACLEDSEBYPADREASTIIGONN TCEOSMTPLEDTAEY 40 547230 SPARCERPIUFTIICALEDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 2 2 2 2 san23s SPRAECPRUITFIIACLEDSEBYPADREASTIIGONN TCEOMSPTLEDTAEY 40 20 20 47236 SPARCERPIUFTIICALEDSBEYPARDAETSIIOGNN CTEOSMTPLEDTAEY 40 2 2 A 647237 SPRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 2 2 47238 SPARCERPIUFTIICAELDSBEYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 2 2 a7239 SPARCERPIUFTIICAELDSEBYPADREASTIIGONN TCEOMSPTLEDTAEY 40 2 2 47200 SPARCERPIUFTIICALEDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 a7201 SPARCERPIUFTIICAELDSEBYPADREASTIIGONN TCEOSMTPLEDATYE 40 27 Fd 2 a - Company Sanilized. Does not contain TSCA CBI me 9H-02-4D5a1y6:GaSvuabgcehrSotnuidcy Toxicity in Rats withOneGeneration Reproductive Evaluations DuPont 5386 --- INDIVIDUAL CLINICAL OBSSRVATIONS IN 7) PENALE RATS GROUP: II-1 DOSE: 0 MG/KG/DAY ANTAL NOMBER oBsERvATION OFBISRESRTVEDDAY OLBASSETRVDEADY 47277 SVAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLETTEEST DAY 40 5 san278 SVAAGCIRNIAFLICEBDATEBNYCYDESCIOGMNPLTEETEST DAY 40 10 10 47279 SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLETTEEST DAY 40 5 5 sa7280 SVAAGCIRNIAFLICEPDATEBNYCYDESCIOGMNPLTEETEST DAY 40 1 1 san201 VSAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 47282 SVAAGCIRNIAFLICEPDATEBNYCYDESCIOGMNPLTEETEST DAY 40 12 12 12 12 647203 VSAACGRIINFAILCEPDATEBYNCYDECSOIMGPNLETTEEST DAY 40 Bn 13 - san280 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTETEEST DAY 40 13 1 647285 san2s6 SVAAGCIRNIAFLICEPDATEBYNCYDESCIOGMNPLTEETEST DAY 40 SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTETEEST DAY 40 12 12 1s 1s 647287 san288 SVAACGRIINFAILCEPDATEBNYCYDECSOIMGPNLETTEEST DAY 40 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTETEEST DAY 40 12 12 12 12 47289 SVAAGCIRNIAFLICEBDATEBNYCYDECSOIMGPNLETTEEST DAY 40 12 2 - CompanySanitized.Dossnotcontain TSCA CBI mm H-02-4D5a1y6G:avSaugbeehSrtoundiycTionviRcatistywith One-Generation Reproductive Evaluations DuPont5386 =~ INDIVIDUAL CLINICAL OBSERVATIONS IN F: FEMALE RATS GROUP: Iv-1 DOSE: 25 MG/KG/DAY ANIMAL --_-- VEER oBsErvaTION OFBISRESRTVEODAY GLRaSsZtRVDEaDy. TTT Tm 607326 vSAACGRDIuFLICEpDaTBEYNCDYEScIoGmNprTeTEEST DAY 40 2 2 6727 vSAAGChRIuFAILCEeDATBEYNCDYEScIoGmNpLeTTEEST DAY 40 n u 6728 VSAACGRIINFAILCEpDATBRYNCDYEScIoGwNpreTTBeST DAY 40. 1 1 6723 SVAACGRIINFAILCEsDaTBEYNCDYESCIoGwNpLTET2E5T DAY 40 1 2 6730 vSAACGRIINFAILCEPDATBENYCYDEcSIoGuNpLeTTEEST DAY 40 5 1s 87331 VSAACGRIINFAILCEpDATBEYNCDYESCIoGwNprETTEEST DAY 40 1 1 6471332 VSAAGCIRNIAFLICEsDaTBEYNCDYEScIowGpNLTeTEeST DAY 40 n n 67333 vSAaCGRmINFAILCEsDaTBevYcYDEScIoGwNprTeTEEST DAY 40 un 12 - 547334 VASALACOGRPIIENFCAIILCAEPDBAOTBTEHYNCDYFERSCOIoVGwTNpLFETATEW(ESST) DAY 40 "1 h1d 7235 SvAaCGRhIuFAILCEeDATBEYNCDYEScIoGMNpLTeTEeST DAY 40 n n 67336 vSAGCnRIuFwICEsDaTBaYvcDyEScIoGwNerTeBrSsT DAY 40 n u 61337 VSAACGRIINFAILCEsDarBsYNeDyEScIoGwNpr7er2e57 DAY 40. . o seme VSAACGRIINFAILCEmDaTBEYNCYDEcSIoGwNnieTrEeST DAY 40 n Bn 6739 SVAACGRIINFAILCEpDATBEYNCDYEScIoGwNpeTTEeST DAY 40 2 2 647300 VSAACGRIINFAILCEsDaTBEYNCYDECSoIwGNPLTETEEST DAY 40 n n 647341 VSAAGCIRNIAFLICEPDATEBYNCYDEScIoGwNpLeTTEeST DAY 40 n n 64732 VSAACGRIINFAILCEsDaTBEYNCDYESCIoGwNpLTEETSET DAY 40. n 3 - Tm Company Sanltized. Does not contain TSCACBI 0H--2D4a51y6:GavSaugbcehSrtoundiycTionxRiactistywith OneGeneration Reproductive Evaluations INDIVIDUAL CLINICAL OBSERVATIONS IN Fy FEMALE RATS GROUP: VI-1 DOSE: 100 Na/KG/DAY DuPont5386 _AI--L war OBSERVATION OPBISRESRTVEDDAY aCRSsERvDEaDy TTR ew 47394 SAVCARGIINFAILCEDPABTYENCDYESCIGONMPLTEESTTE DAY 40 12 12 647395 SVAACGRIINFAILCEPDATBEYNCYDECSOIMGPNLETTEEST DAY 40 1 1 sa7396 VSAACGRIINFAILCEBDATBEYNCDYESCIOGMNPLTETEEST DAY 40 n n 47397 SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTEETEST DAY 40 10 10 san398 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLETTBSET DAY 40 12 12 547399 VSAACGRIINFAILCEPDATBENYCYDESCIOGMNPLTETEEST DAY 40 1 1 47300 VSAAGCIRNIAFLICEPDATEBNYCDYESCIOGMNPLTETEEST DAY 40 12 12 --- sa7401 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOMGPNLTEETEST DAY 40 3 n sa7a02 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLETTESET DAY 40 n u 547403 VSAACGRIINFAILCEPDATBEYNCYDECSIoGpNLETTZEST DAY 40 12 12 47404 VSAACGRIINFAILCEPDATBENYCYDECSOIMGPNLETTEEST DAY 40 u u 647405 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETEST DAY 40 10 0 ~ - Tm Company Sanitized. DoesnotcontainTSCA BY 2H02-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistwyith One-Generation Reproductive Evalugtions DuPont5386 --_ INDIVIDUAL CLINICAL OBSERVATIONS INF, Peaus RATS GROUP: VIII. DOSE: 250 MO/Ka/DAY ANIAL WnaseR omsERvATION OFBISRESRTVEDDAY GaBsetsRvoEaDv sa7436 VSAAGCIRNIAFLICEBDATBEYNCDYESCIoGMNPLTEETSET DAY 40 10 10 47437 SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTEETEST DAY 40 u u sa7438 SVAACGRIINFAILCEBDATEBNYCDYESCIoGuNPLTeTBEST DAY 40 20 20 647435 SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLETTEEST DAY 40 n un sa7440 VSAAGCIRNIAFLICEPDATBEYNCDYESCIoGmNpLTEETSET DAY 40 1 13 47041 SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTETEEST DAY 40 12 12 sa7442 SVAACGRIINFAILCEPDATEBNYCDYESCIoGwNPLTEBTEST DAY 40 12 12 ~ 47443 SVAACGRIINFAILCEPDATEBNYCDYESCIoGmNpLETTEEST DAY 40 12 2 47440 VSAAGCIRNIAFLICEPDATBEYNCDYESCIoGMNPLTETEEST DAY 40 12 12 sa744s SVAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTETEEST DAY 40 2 1 sarads SVAACGRIINFAILCEPDATBEYNCYDESCIoGeNrETTEEST DAY 40 2 12 47447 SVAACGRIINFAILCEPDATBEYNCDYESCIoGMNpLTEETSET DAY 40 n u mw -------------- Company Sanitized. Doesnot contain TSCA CBE