Document qkpVXVym1JVqqmNBraOnLyGrE

wilih OATE c AMAT! RPTR January 23, 1961 O .T Dr. W. M. O'Donnell Lancaster Genaral Hospital Lancaster, Pennsylvania Dear Doctor O' Doncell: A few days a.39 1 had aa opportunity cf studying oectioas cf *.. .* .tisanes obtained at autopsy fro m tra former employees of the asbestos plant in Mannheim, which has proved to bo.according to your .eaperi- * eace, a rich scarce of asbestosis cancer ef the lung. While ccn of the s workers seemed to have died from a multi centric adenocarcinoma of the lung without showing any asbestos bodies in the lung, the second one had scattered asbestos bodies in the lung in addition to aa euteosivc mesothelioma cf the peritoneum. Similar cancers involving the pleura and the peritoneum have occasionally been observed in Germany, while a rather largo cumber of such cancers has been found among South African miners of blue Capa asbestos. I am enclosing photocopies of two papers dealing with such ob servations since they may not readily be available to ycu and because you may have come across similar casco in ycur own work. - . i.. i - i. = . ; : .c . it V- . : .. " :*T .: ' Ycu may be ini ores ted to know that -Dr. Therms' Mane use, ' '' Columbus, Ohio, has recently conducted an epidemiologic analysis of the occurrence of censors of nil oite3 among present end former employ * ees cf the hrannkeim'plaui, which seems to have yielded acme interest * lag results. If ycu should hove hep: alive your ccicnsiHc interest in this problem, I wonder whether it might be mutually profitable if ycu -* and Dr. Mancaoo weald get together to euchange ereperisnees. -I am certain that Maacnso's interest in this occupational cancer knoard is essentially limited to epldemiyclegic observations ns they could be ascertained from a follow-up of data provided by the Bureau cf Cld-Age and Survivors' Insurance, although he has also some information cn. pathologic aspects. - In view of the defective data and misleading if not false con- . elusions recently published bv Broun end Truan who mis 2ed 3-1 casco of asbestesis cans er of the lung studied at Saranac Lake l aboratoriu.: for the asbestos interests of Cue bee by Yorwnld (1 e cases) and later on Scanners (13 car-;-.), it would he mee.et imsorlani, in mv ooiaioc. if I DC j-~_(?c :: /r>crjr u %; y-i v, _ 1 * * Ci'* . *. i f.-i rv. -'S'.v- r-r jrs-.LSv;? o* r'r=.:' . a.- v1 /:: ; . ** *V* ":. ff* ' 5*; __ v * - -j-% - -r Pa'2? `-4 - * .- c r ' ,r L.rr.- .y-r v..- ; ;c c. . h Dr." W. M.rO'-DortniU'f*' <W2- ;** a--- 1/23/61 t- ,, .r *. * sr.y>;~':/ ; .< !*`T * , ;a"o': your~o2>aefrations 6a cancers cTtha lung in wofhars' having contact "r ' with Canadian asbestos would hemade the subject of a comprehensive' report. -'Perhaps 1* tfay add fo the'significance of Such a'contribution ' ` if such a'paperof ysnrf would be'pab*Ishe=d at the'sama tirrio and ia the aarr.e-Jourhal together", but-eapafately with-the"'report on the epidemiologic survey cl "Maneuso. - I am" certain that l^fahcnao would lei you have all the pathologic data-he had available for you toinclude ia your'paper if you so casim. - ftt" Jf. s f - - i .* ; ^ % > ' > V. i . . i w | - - < If this"proposition "should appeal to you'l should ha glad to" approach Mancuso on this matter so aa to bring you two together. Will you kindly let me have your reaction? ' ; .* . *T ** c" - ~ o-.-a-';. o-:* sv-' ' i*. * / ' : - r;i r*--Cordially youf-s, " -V /c < . . A`1 . * * i .t- * ^.C. Ehopcr, M. D.t -CHef:- Environmental Cancer Section' National Caacov Institute : Enclosures' * *'T* W5, c- . :;*.r> r. Leicher,;^1. , Prirnarer Decks disc,turnor des Bauchfells bei Ashestcse. 1 ?v?/rchiv fur Gewerbepathoiogie unu Gewerbehygiece. 13:302-392,1954; ^agner, J, -C, Sleggs, - G-.. A*, and Mar chand, P., Diffuse Pleural Meso thelioma and.asbestos exposure in the XordfWe stern Cape Pro vine Brit. J. icriustr. Med. 17:260-271, Oct. JV60. cc - Dr.' Thomas F. Mar.cuso, Ohio St. Health/ W. C. Hueper, M.D., Chief ircrjtentai Cancer Section Na ional Cancer Institute Be hesca Ik, Md. Tear Dr. Muster: I as still accusulatin* data with respect t association of pulsenary asbestos is and bronchogenic carci -c" have 39 cases of proven puLto.nary asbestosis, 19 cf vr. associatec uroncr.oger.ic carcincsa. I-t had bee:; ay nope t o2~ ^0 cases of this disease to show our incidence cf carcino.ta. This would be a presentation cf a material comparable to Lynch. We have seen r.o case of mesothelioma of either pleura or oeritoneurn in our saterial. I will be glad to discuss this problem with Thcras fencuso if he desires to visit Lancaster. we / -- Very truly ycurs, 7jJ (S^J1 Ch <C 'O Ward M. O'Donnell, M.D. Director of Laboratory. /