Document qk58mD4xV39EYg2GZG6rJGrRx
Original Contributions
7^203^
2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels in Adipose Tissue of Exposed and Control Persons in Missouri
An Interim Report
Donald G. Patterson, Jr. PhO: Richard E. Hoflman. MD; Larry L. Needham. PhO; Daryi W. Roberts. MEd; John R. Bagby, PhD; James L. Pirkle, MD; Henry Falk, MD; Eric J. Sampson, PhD; Vernon N. Hook, MD
The compound 2,3,7,8-tetrachk>rodibenzo-p-dioxin, commonly known as dioxin,
was measured *m the adipose tissue of 39 persons with a history of residential,
recreational, or occupational exposure in Missouri and in 57 persons in a
control group. All participants had detectable levels of 2,3,7,8-tetrachkxodiben-
zo-p-dioxin in their adipose tissue, but the exposed group had significantly
higher levels. Levels of six of the exposed persons were more than five times
greater than the level of the highest control. Measuring 2,3,7,8-tetrachlorodi*
benzo-p-dioxin in adipose tissue provides a much improved index of exposure,
an important advance for research studies evaluating the possible health
effects of fhis compound.
{JAMA 198656:2683-3686)
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jama. Me 2 i. 19S6 --Vol 2S6. No. 19
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2684 jawa. Nov 21. 1986 --Vof 2S6, No 19
Oown Le-vds --Panefscn el at
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18
te
14
I? IO Controls
8
6
aZoo0cor.i)
4
2
0 4 e 12 16 20
Levels of 2 13.7.Btetrchiorod<beni*p-dio*in. com monly known as dioxin, in exposed and control persons in Missouri.
Exposed
I Residential H Occupational
Recrea lional
7^ I .4 8 12 16 20 24 28 32 36 40 44JL4^8L5_225L6J6H0 100 k200 300 400 500ja6_00 700I_60_0
Dioxin Adipose Level (P arts.per Trillion)
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11 i-nv 11 1
ATadbipiosel.--TisCsoume poafrEisxopnooseidthaendLeCvoenlstroalt G2r,3o,u7p,s6-Telrachkxodibenzo-p-dioxin (Parts per Trillion) in
V ariable
Arithmetic mean Median Ranpe Geometric mean Mean ape. y (SO) % Men
Control*
7.4 6.4 1.4*20.2 6.4 52.6(15.7) 35.1
Total
39 79.7 17.0 2.6*750 21.8 44.3 (13.7) 61.5
Exposed Recreational RaaidanOaf
8 16 90.8 21.1 23.5 14.5 5.0*577 2.8-59.1 24.8 15.3 42.1 (14.7) 39.7 (14.9) 37.5 43.8
O ccu pation al
IS 136.2 24.7 3.S-750 29.8 50.3 (9.8) 93.3
KTanbolwen2T.--CDCDomExppaorissuorne*of Che Adipose Tissue Concentrations of TCOO in Populations With No
Source of Specim ens
N
Uean, Part per Trition
Range, Parta par TrtiMoo
Present study: elective surgical pelieoia in Missouri 57 6.4 f 1.4*20.2
Aulopsy specimens from Oho"
6 5*12
AuatodpipsyossepeIrcoimmevnesteIrraonms"Si Louts" and Canada1end 611 7.5
1-15 ,
Aulopsy specimens Irom sudden deaths in Si Louis'* 35
7,21
Aulopsy specimens Irom Georp>S*and Utah'1
35 7.M 2.7-19.0
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JAMA, Nov 21. 1986--Voi 256. No 19
Oo**n l C-V1.4S--Partin son el al 2685
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Reference
6tAeA5eptHis4em3MiDFB2AEin1.n.uoto.nno.m.u.iooiurgnPtsedgnaFotLdoirPneAelFhtJAEchxlctayhmdendeioehli-iemtcsopC..pC-cbtinnrif,mp6ecbtdeysleApreaOehh0theoxesosT,seaee2rln.e0sesueneocseardn^1ui/ntanesxtltotn2Pfi9t7Rubpeoloo-nks8W3C^-tef1m81SefpCr0eio1opMc-u9Rp90o,F.ep,,fthirie8D8r-one,tfcotpFP1ae6rt6hi21GrUtrCe-cmn9^e.o^rt9gecL^tPd87orrT,s8rr8ee,p3iue.e.inc7m:3-.se1iqo.lq7tm7tHhc7e.,ol9uU1ttt08fe1ucmi.lroe8ymJ98moso5o3t-ihaS5recr8-tl-tn-arsenr^eiThle7f7h3AoocenoGr7fttt1.1fECreldsre!irm..noao63-taoDTnrain2ar.ri.MbcsveWJnnMviO7DgtonhSeteia1Dieoo.vnBrehnlirt,7l:osgohnnGyteDuxi-,sernnrte2osCLAmo,ooardm7imrDyd-agusind2etphtppdLenrueieyStn-buCieihoietpanxi,.ndbexdcnmyfuatthtireasMmdDrM/dyeomrenha)Fhlriixoieo:nctipsu!ECoiAogi,-PttnaomnD;xiRop-hbrEaosJMiapD-po-,enieAtond,dr-siihtniinedroiteiet:saeperaoisicnstiTrsroottoxaetobtiosAisrahnlndmuuoueeurieoleaSdninlrynle.k.;f;i,.
tNt(prp92nC8iAaI1hPDS7tty11anania.noJy0..4eae.mhseCn.l.tt.d,l1tvs7fcrieMyaMP,Rie4auSeKesm.oNrCcn.8rAREtnyteineicnhuoiisi-.yahsatpmnacNogenaTllt,smgenioxaltteeflvnuCoeaimrFrrnniioae1srltfMi,JrOoteFadpnin6niyoJCcsAnrdra,WirHaDae.hpntaeedtherlMpW1,oseoeCnm:npyWte9rssfidss.Se8iomnP.SeCiuecCilr5ynimHSgc,n2ossclid.hh2mlcoettN^hnaoipEieea9imacabn,nplsmtfmomi-7nltlmareseaoMoiuto.Svoitnaueilah8snncstcsilnoxniePoiaeek-rsadeoau.pcytnroreDlnl!-emAioof,aypne-t3rSJERsMRrtSbC-mto:,Bees(ovdoAxesm:meMd.cc1ceapinAataMptho9ririRydiodoPeptatil8xoWCreohcotscsahlc5einyeiuaooprnh.atbcu,btoKnrtcrfpalriaethoteeo1nadm5ehA-AfCtfe9dgr5itioa.obiiMa,o8mCh,y,inrnsrtcc3WneeeL:osedEuao,noWnmouaxtlAnneikpc1eayefiodits9aivyticdtchntih-1nt8tstJiobapaesho51rheeOcGlrelaDo-7e);tliy(idnr.lio,.nSnnEei:cscliauogFeoFmrUii1gosoPodsxtmttci4oxmtoftfeiAi0tiaaountieoonananh6nha)hd-stff,t-
HGtFD3CCbHTorO1s1ROpr1BAoe3Zui5ne4i3eaeihh-dueatfd:ufeof..A.pltrr2ftallecmovrtaxieCmhoo-6dhkscCGPriGwddirr1asceo.hgen.aoaiirr-onbharfnlosrnIW2aotcWsaoroe,lntaox6yhaytstoehrfuaahtatO8iasrVf.eoairfeeanndnbtn.esCsosmrcdeSrmdiidhPotaoeMdepntimoeintnentDoiGaneFmpR1ntbssLeMsthcgdh6ittiaeMeieeonmifeet-ouDm.rcnloti11xtr,mLamDnnhiid8i6nCtiHFdttoan,aa,ttaei.aae,ooHe-oyislivadt1nn1nplIDeuaxde9ie9nyaH-ttriJSCC8mi8thdUnet,noatpOef5oe4yhe,meiodsnonSaor.S.orlxm.marl1ndnseaxIRpeaVHns9eppnaLnpiron2a8senFtoteteToys^1md.ilettsaDauoJ.ou1,oeiriF7lpStl7rsnnnnuxrRe.etE,eDs,la,hdi6amvadeuecnnW1s.l-etPslSeiLsvC,9El.atAosSo8eimteKoSBoRfrneAv5.ntsfnimoyrid.ibeaaeandratde2nmaliyacmhlpccmtid^CCttraoSnhpsape,dohui7iagbySRonulDnooiemnlJmetsoJtepoirfJsJ,hdif,esaoop-ur.po,s,2ttTHidsomr,o,ereneeJCiaWeuRest1lBa,bttpniD79rteittueaebre8odhioaa(aaDnym8seLs4idslnendtt*--:;;.,
2686 JAMA. Nov 21, 1986 --Vol 266. No 19
Doun Levais--Petier son el al