Document qdxnmNoZ3ny879Kbv4ezLLqnj

Dr. A. J. Lanza, Aaalatont Madloal Dirae*.or, L*atropolltaa Lira Inauranc* Cm my, Ha* York, H.7. Daar Dr. Lanza: Z m aaeloaine tha rr^ort of Dr* Millar, Mr. Proaka, Ur. Brubaab, and Ur. Stoll, for tba aoath rf January, 1935. Slnoaraly youra, 3 -'3 'i IS t '> ' *? January, 1W. Monthly pert of Dr. y. *r. aur, ar. s. o. rmto, Sfr. X. r* Brubeeh, u4 Ur. B. J. Stoll. Xatraperitones1 Injection tacts. 90 day Injection tests aere conplatad on 3 samples of asbestos, via. Canadian, Croeldollte, and iaoalta. These *sta hosed that tha notarial produead as inert typa of reaction. This region ee baa baaa Interpreted aa eharaetarlatlo of a dust capable of ^reducing pneumeeonleale other than allleoala. 30 day taata vara completed on a atnple of doloeuboi*ted for taat aa to ita suitability for uae in rock iwtii.-. Ti.v taata s':iov**i thl* material. to ba absorptive in eharcetsr and therefore rot of ecy rreat poten tial Uanfulneas. frparlaaata with variable Quantities of duata. Three rrr-.ira tf animals injected respeetltely with 6.005, O.06I end C.0005 gn. of olr aanaratefl quarts vara killed aad ssaalaed SO days after Injection. Dust nodules ware aaaa is tha anlnala, lajaetad *1*1' the larger doee -roup, but aare absent la tha 0.Q0QQ 91. sroup. This presumably ladleataa that 0.009 of alllea aaa ba absorbed without gross Injury la SC days. Anothar aarlaa of experiments af 90 days duration ara now on taat. ykelaidaal aanlnHleu. A aat of luags ware raealvad for examination, history nan not jut Wan racalvad bat Is rspeftad to ba on tha way. factions aad ansaim specimens aera praparad. The rross appsaranae la that of aliiconsthreaorta. ftotgdarogaaha. A oorlaa of 19 phofoalerompha showing tha hlatolagleal eeveiopaeat of nodules paodnead by quart*,limestone, and aathracita coal vara oada. lhaaa platuzea ara 633 mngniflcati oas and sho tha nodulaa T. 30, 90, 180, and 390 days aftsr lnjactloa. They *111 ba uaad a a 1'.lus trations for tho paper on tha histology of dust nodulaa. goal aids cih eeattai^- a paper aa tha parltonaal response to various duata was glass at tka Matin# of tha Conlslda Club in 7e.ahington.Muaeua apeelnana of tha gross tlaaoaa and photomicrographs vara uaad. Snaetroaaoale wort. Ur. Armstrong emtinued azparlaants on tha apaetroscopic datarainations of adnata quantities of alllaa, both soluble aad insoluble. A qonlltlotiT* aetbod la complete and a quantitative detera!nation net hod la in progress* illeroacgple examinations. Tha histologic study of nodulaa produead by various duata In tLa paritossal cavity was continued. laboratory administration. The shop *aa rnnovad fro* tha preeant laboratory to a reoantly squired roan next door. A dark roon for apaetroscopic aork was constructed la another roc* adjacent to tha aaa ahap. Thraa hunrtrsd tad sixty dty UiU aara eoaplstsd on 2*"oolta ahlta (t tlllostt used s pslnt baaa tad fillar) tr.d " tale* Tha satroalts fblt* shoaad a sary ale* #>*ooTfti.on rtact'on. Last of tha duat praaaat than vtt ori*J tally lntroducad, thtugh It had tot aatirsly dlaappsarsd In 340 dtya. 7h* talc sia typically tnart lr lto rotation lo tba i<srl*oaaua Aa **"* of tha talc was found la tba tlssuso la ?40 dtya to aaa let-oduead Into tha pa-1 tonoal aatlty. St*WtlOCTS OUKTIOH T.3T3 A aortas of rats aara lajsstsd subsutaaaoualy alth four d Ifftrait dusts aosordl&4 to tha taahalfaa of Gya tad lattls* Thay aara klllsd tad 100 days tftsr lajaatloe. Tha r"<-lta aa-*a as follsss: Ctlslts. All of tha orlflttl Jnst has dlaappaarsd, only t faa aaell arasa of s* -*r broan at *><* tits of Injection la tha suboutnnaoua tlsaua rasalnad. oosl lha soat dust ass found diapsrsal throughout tha tohsuttasoua tlsaua tround a iarja flattsaad aran of d'iat a' alts of tn'actlor. As auoh duat ass present aa aaa latrodu*d jj^trta. A aodarata alr.ad aodula consisting of a eaotral aa,ss of usSffaotsd dust, su roundad by a fairly thick fibrous capsuls **a found at tba alt# of lajsatlsa. Tha alas of this aaa c-ly sllchtly larjar than tba blab fc"~ad fcy tha lajaatad d"*t. S&ert (Chat). produce4 i.cduLaa I dentiel to thoae of quarts. Tbe calotte and blturilaeu* "'1 beheved tr *:;`>.'taBeoue tleauee elullerly to tbeir notion in tbe p-rltosaal cavity. Ibe reapooae to quart; -<* chart nn not ca *!'. dfflBed. 2eoatae of their er.cepau- latiea the*e la sr JcuM that aoaa Irritative reap r.aa ana elicited, yat tic aod>.le ear*- rot celi-lr in atnjetura 11'-. foee fitrd U the paritr.raua. '.etioh 1" . .arltoraO ' oaout xueh so'- dee lrhi a fer uaa a; t Molo*lcal taat of the bamf'.lsaaa of a t.s'.. :tsucu:ius The paper for presentation at the Clovalnnd aaatlnf of the Aaarleas Uadiaal daaooletloo uaa oaapleted and aa aubaittad to tha editor of tha Journal of the iaarioaa Medical deeccletloo for publleaties* It eoeara tbe aerlea of duete rapvtod in the public eealth fieporta, Jaa. lt( 1994 end la additloo loeludaa tbe ieo "* 564 day t*ate, thus eoapletlae th4 7fc-,ee of etudy. rBTBKffiinfclC e^LXSB fotrtjraphlo ecalyaaa have been uada on *11 duets used 1* these atudiaa. the aaal.r ca wara replied by tha courtaay of the U. 8* Bureau of lllaee. 3Be eericlte aapl* aubaittad v 2r. . McConnell es-.t<nd: ^arta 50JC; kuecovite (ear. rieita, <?; fibrous e--`',tte 5.1.