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FILE NAME Brakes BRK DATE 1968 DOC BRK303 DOCUMENT DESCRIPTION Letter to the Editor - Asbestos and Mesothelioma silica Smith personal communication used chrysfroomtAirilzoena Letters prepared by the Badollet and Gantt method to produce mesotheliomas in hamsters _ Weobtsa imili ar rn esule ts wd ith pure chrysotile in mice These in Smoking and the Coronary Arteries findings indicate that asbestoisn var formi s co au u ss e thelioma in both animals and man thoughtful the Editor Seltzer's To and documented re- of Smoking and Coronary view Disease 203 1968 makes no reference to personality factors Perhaps there are no re- search data about personality dif- ferences of the cigarette smoker in contrast to the pipe or cigar smoker but popular attitudes generally suggest that the pipe or cigar smoker is more phlegmatic and less likely to suffer from tension states A striking difference in the incidence of coronary disease is found be states Wagner's findings that the time lag between last exposure and tumor formation was always long averaging 40 to 50 years However Kleinfeld et al reported onset of exposure dea totdeh ath was 29.5 years witha range of 15 to 40 years patient a chrysotile worker died 23 years after the first three exposure Another pa- tient we have seen died of mesothelioma afte1r5 conotf i connti-n- uous expo We hs aveu alsr o se een a young man who died of acute Apparently tween the two groups the Surgeon General's Advisory Committee on Smoking and Health quoted by Dr. Seltzer in its list of predisposing factors mentioned only occupations involving and ignored individual personality factors basic to psychomatic dis turbances which may predispose to coronary heart disease BURRITT S. LACY Jr. MD Manhattan Kan Asbestos and Mesothelioma To the Editor recent letter 1142 1968 states that the problem of mesothelioma formation is not one that involves the whole asbestos industry but only users of crocidolite and this mineral represents a relatively small proportion of total consumption It has been workers that mesothelioma chrysotile_er- who worked in a Canadian asbestos mine five years and who died of pleural mesothe 15lyeiaro s amftaer the first expo Anals ysiu s ofr tise sue by ray diffraction indicated that chrwy as s theo onlt y fi orml of e as- bestos present Wagner and Skid- more induced mesotheliomas in the pleura of rats that inhaled chrysotile crocidolite amosite and 674-684 1965 2. Wagner J. C. and Skidmore J.W A bestos Deposition Dust and RetentiniRoatns Ann NY Acad Sci 77-88 1965 peritoneal Acute Toxicity of Asbestos in Mice Enviroa Res - to be published 4. Wagner J.C Proceedings of the Pneumo- consosts Conference Johannesburg A. J. Aren- stain ed London J. & A. Churchill Ltd. 1969 5. Kleinfeld M Massite .; and Koojman .: Mortality Experience in a Group of Asbestos Workers Arch Environ Health 117-180 Aug 1967 Intrauterine Rubella Transmission To the Editor recent articles by E. B. Buynak et al 204 1968 and others demonstrating the feasibility of attenuating rubella virus in a manner acceptable for vaccine use provides great expectation that this disease will soon be controlled Unfortunately during the time required to produce sufficient immunity in the population many women and their physicians will be faced with the problem of rubella occuinrthr e i firsn t tg ri- tion another woman who experi- . enced rubella in the first trimester has come under our observation upon termiofnta he t pri egnoann cy the fetus from this woman was infected with the virus Thus in lab- IAMA 6.202 A SAR -VMI -VMI -VMI --