Document qdbvdDnN3nGovDbad9mx5bM8R

R&S 025367 K.r p.ii*., i 1st., *'. A.; ! Unlit, ' Carcinogenesis Abstracts . .> - 1 VVwTw41''! ' Abstract and Citation # 0601-1200 vi; February, 1976 4'IM' T/f % ' i; t'-CUPA /<-^64'5' K' /7" THE MUTAGENICITY OF 'CHI QROFTHYLENcioxlDE---- CHLOROACiTALPEHYDE, 2-CHL0R0t'THAN0L AND ,'CHLOROACETIC ACID, CONCEIVABLE 'MEtABC?LITES Of gymi" CHLORIDE". fCne.) Rannug, U. (Wallenberg Lab.. niv. Stockholm, S-104 05 Stockholm, Sweden).; `Cothe, R.; Wachtmeister, C. A. Cheni Biol InteraoL .2(3-4): 251-263; 1976. he ability of four conceivable metabolites o vinyl chloride - chlorocthylone oxide, chloroacetaldehyde, 2-chloroethanol and chloroacctic Shield - to cause base-pair sabsc I r.ution directly in ^Salmonella typhimiriien TA1535 was compared. The ^attain comparison was performed at initial concen trations from 0.1-1.5 mM, In this region, however, fa mutagenic effect was observed only with chloro;)ethylenc oxide and chloroacctaldehyde, the former being approximately 20 times more effective than Tthe aldehyde when compared on a molar basis. 2Chloroethanol and chloroncetic acid were also