Document qdOkV2qvRmGVZQzavvGmzZrBR

- @UPOND January 28,2005 Beciven PPT CBIC WSR AHI:p 29 AR226-1941 fooSuHnasask rkd ELantosrseaayn Scinces Newark 08 oie0 poenpoeonnpcaeuiconrany UE] Via Federal Express Tg A 3p. Room 6428 `AOtftfeincteioofn:P8o(ll)utCiooonrPdrienvaetnotrion and Toxics U12S0.1ECnovnisrtoitnumteinotnaAlvPer,oteNcWt.ion Agency CONT.ANS no c8 Washington, D.C. 20460 Bet ols 1549/3, Dear (e) Coordinator: 1-Decancl, 33,44S,E5H,5Q.O63,-611,574,1882,99,10,10,10-heptadccafluoro- [CAS #678397) " m"Tehtiasbeotleisrmi, a0ndinefloirmimnyaotiuonoft(hAeDMreEs)ultsstoafya irnetcheentrlay,caolmopnlgetweidthabcsoomrppatriaotn,ivdeisitnrivbiutoion, 833 9523 N`"Tmohevitsealbmtobtleeirrsmi2s5e",xFp2oe0rr0iY2moe[unAtrRs2I2un6sf-ion1rgm1a4rt1ai)to,ann"dahsuamfaonllhoewp-autpocoytqeusalwiittahtitvheedaabtaovseuprpelfieerden(c0etdheteAstgmeantceryd5f3?, ~5~75 88 M0a.l5e% aaqnudefoeumsalmeetahtyslcweelrleulaodsmeivneihsitcelreedaathseintgalregeotradlodsoesleoevfeltshoe ftesmtgm/atkegriaalnf1o2r5mumlakte.d inTah--e bfloermnudleadtiendtodotsheesdwoeseresoflourttiifoinedprwiiotrhtoraaddimoilnaibsetlreadti[onC.]Iensatddmiattieorni,alm,awlheiacnhdwfaesmaulneifroartsmlwyere `amdemtihnyilscteelrleudloasesivneghliecldeeramtaaltaarpgpelticdaotsieonofoft1h25emegs/tkmga.teFroilallofwoirnmguloartaledanndtdheer0m.al5%dosing, ats awnedrfeehcoeuss.eTdhienddeivrimdaulalldyosien rgleamsasimneetdaibnocloinstmacutnwitistshtahbedloersfaolrstkheinsfepoarr6atheocuorll.eActtionthoeefunrdineo.f tdohsei6n-gh,oruartsexwpeorseuraen,estthheetaipzpelidcbayticoanrsbiotenwdaiosxwiadesheexdpotsourreemaonvdeseaxcrciefsisceddosbey. eAxslan1g6u8inhaotuirosn.posAtl- Saadcmriinfiicset,ereeldecdtoesdetwiasssuedsetweerrmeinteadk.en for adioanalysis, and distribution and total recoveryofthe Idnucotrcdaenrntuolraetseodlvmeatlheeaonrdigfineomfarladritosacwteirvietaydemliinmiisntaetreeddian stihneglfeecoerslfodlolsoewiofntghoeratlesdtosmiantge,ribaillein h12e50m.g5/%kgmedtohsyelcleelvellusl.oseFovlelhoiwcliengindcoosripnogr,artaitnsgwreardieohlaobuesleedditnesdtivmiadtuearlilayliantgbloatshs tmheeta5baonldism ucnoiutnstinBgile was collected for 120 hours and analyzed for total radioactivity by liquid scintillation MEER - MR 282945-- `Ipnesrefplauroarotoecetxapneoraiteme(nPtsF,OAth)ewpalsasdmeatekrimnienteidc.s oGftrhoeuptsestofmmataelreiaal,ndisfeamcaidlefroartms wanedreaamdmmoinniisutemred a tseisntglmeatoerrailadloasteoboftthes5tamnadte1r2i5almign/kthge. 0F.o5l%lomweithnygldcoeslilnugl,osreatvsewhiecrleemianicnotrapionreadtiinnggrlaadsisolabeled c`emnettraibfoulgiesdmtuoniitssolaantde psleraisamlab,lwohoidcshamwpalsesanwaelryezecdolfloercottedalporsatdi-odaocsteivfiotry7bdyaylsiq.uiWdhsocilnetiblllaotoidonwas `mcaotuenrtiianlg,bfyorLCth-eMtSe.st material by GC-MS SPME, and for PFOA and the acid form ofthe test `Inmeatnabaotltiesmmpotfttoesgtaimnatienrsiiaglh,t rianttoansdpehcuiemsasnimhielpaarittoiceystaensdwdeirfefeirnecnucbeasteidntihneacclleoasreadncceonatnadiner with (thdeistaepstpemaartaenrciea)l bayndGsCe-riMalStiSmPeM-cEo.urAsdedsiatmipolnaels winecruebattaikoennswaenrdemcoonnidtourcetdedfowritthhertaedstiomlaatbeerlieadltest `material to aid in metabolite identification. fRerpormesraetntaantdivheusmaamnplheespoaftoucryitnee,infceucbeastieoxtnrsa,ctwse,rbeilperoefxitlreadcbt,yaLnCd-pAlRasCmraaedxitroacchtrso,maantdogerxatrpahcytsand screened by LC-MS, along with matrix control samples to resolve metabolites as a resultofthe test material exposure. Ifnoltlhoewoirnaglastudmige/skdeessiignngleedotroalasdsoessseodfistthreibtuetsitomnaatnedritaoltatlormeacloevearnyd, tfheemarelseulattss,shaoppwrtohxaitmately p3o7r%toiofnothfeuandambisnoirsbteedrepdadroesntetarlacnoshiotlewdtahse1G.I3-tfroalcdthaisgihnetraacttptahere1n2t5a-nmdg/wkags-ndoosteablsevoerlbe(d~5.0%T)h.e tBhaastewdaosnaabnsaolrybseids offolfleocweisnagnad5thaendbil1i2a5rymegl/ikmginsaitnigolnesotruadliedso,steoheftpehrecetnetsotfmaatdemriinailswtearsed dose mapapirnolxyiimnattehleyfe5c2es%vainadth2e6b%ilereasspgelctuitvaetlhyi.onTehceontjeusgtatmeast.eriEalliwmiansatmieotnabvoilaitzheeduarnindeewlaimsianamtiendor `ehlyidmrionpahtiiloinc pmeattahbwolaiyte(s<.4%)T.issTuheereusriidnueecloenvtealisnoefdtoltoawl lreavdeilosacotfivPiFtyOwAer(e<1g%en)eraanldlynugmreeartoeursthoatnher tlheeveflsa,inlitvheer,wthhoylroeidb,loaonddaatdr7endaalyss,paonsdt-wdaosse.genTehrealglryealteesssttchoannc5en0tpraptmi.onofradioactivity was in wFoalslhoiwnignagtdtehremeanldaopfpltihceat6i-ohno,utrheextpeostsumraet.eriSaylsvtoelmaitcizaebdsofrrpotmiotnhefoslklionwsiunrgfdaceermoarlweaxsproseumroevteodtbhye test material was negligible. lPilvaesdmfaolklinoewtiincgsoofrtalhedotseesst.maTtheerimalaxatibmoutmh tchoencenatnrdat1i2o5nm(gCr/nkagx)doofstehleevteelsstwmeatreerilaolwfaonldloswhionrgt`ormaalxaidmmuinmisctornacteinotnraatti5ona(nTdm1a2x5) mwga/skgslwigahstlnyoltopnrgoeproarttitohneahlitgohtdhoesdeosleev.elT. hFeotlilmoewitnogreoraaclh dosing aftetmhaele1s2o5n-lmyg,/wkhg-ednocseomlpevaerle,dthteortehwea5s-magp/rkogp-ordtoisoenalleveiln.crTeahseepilnaasrmeaa utnerdmeirnatlheecliumrivnea(tiAoUnCp)hasfeo.r was principally governed by PFOA, which was typically longer in males than in females. Ihneptahteoicnytveistrtohmaentfaobrohluismmanexhpeepraitmoecnyttse,s,clseuagrgaenscteionfg tthhaettienstvmiavtoehreipaaltwicasfimrsotr-epasrsapcildeafroarnrcaetofthe tHeoswtemvaeterr,iaglivaebnsotrhabtead fsirnogmlethseubGjIecttrarcetpmreasyenbteedmtohreeheuxmtaennsihveepaftoorcryattes tshaamnplfeo,r hburmoaandsi.nterspecies conclusions could not be drawn. A copyofthe final report for this study will be submitted to the Agency when available. Sincerely, ADi.rMecitcohrae-lRKeagpullaant,orPyhA.fDf.airsand Occupational Health AMK/WIF:clp (302) 366-5260