Document qdGQ4QyQMKR6q5d3aommGganq

March 27, 1975 Dr. Bernard 0. Greenberg School of Public Health - Dtalvwrslty of Worth Carolina Chapel Hill, Sorth Carolina 27511* Dear Dr. Greenberg: It la my understanding that you hare had preliminary discussions with Dr. Boss Adana of Hr Product* & Chanicala and a Maher of the Wteerlng CoMlttee of the Ad Boc VC and PVC Producers Cenittee of the ffl. Iafbrwatlna developed daring theae discussions leads us to believe that a statistically nssningful vinyl chloride doaa response carve for liimiana night be developed through the Investigation of nortallty and aorbldity data aa a re flection of tann exposure on both a retrospective ad prospective basis. The importance of aoch a stady fron both a health and economic point of view Is laodnark. Vinyl chlorlds nononer has been ad in a Iten of ecaerce for IT------r--for^ years, flu sponsoring eoavanlaa In tha 8PI desire to obtain a valid epldenlologic mvey of tana exposure to vinyl chloride. S&la sort la expected to be publishable* Ye oticipate tha very nature of the prohla vill require the nost sophisticated techniques available to allow all parties concerned to draw mesnlngfnl conrlnalona with respect to aanlfestatloa of bnn disease at low VCN exposure levels* fiieaa levels characterise the enrlroonat of plastic fabricators and neighborhood PVC ad vinyl plants. API's primary interest is a search for knowledge. We mold rellahlllty of the data In tbs research to be each to allow tree analysis of past experience ad allow responsible planning for the future. Aa added benefit is that these data will undoubtedly contribute to our understanding of 1 research In relations to clinical tateta epirifrtlogical findings. It would be the Intention of the AFX to use its good offices to place this stady on a basis ad to incorporate infonnetloa ddeh is sfallable fi any aouree9 nsaber companies; government agencies; sad fbreiga affiliates. Dr. Ados reports that the scfrftAl of Public Health has developed a sophisticated computer pxogra which would be useful In handling surrogates of vinyl chloride exposure. As yon know, estimates of vinyl chlorlds exposure in the past will be a particularly difficult profclat in establishing tbs validity of each a study sad this nrmputer program seems to uniquely qualify the School of Public Health fbr such work. SPI23264 2- - Would you be interested in undertaking such a study? If so, I would propose that as a first stage, perhaps on a consulting basis, a feasibility study be undertaken which will define the scope of the project; Its cost; the data input sod what aeaaingful conclusions night be drawn fron the project. Although the Ad Hoc VC and PBC Producers Committee of the 3PI has approved Halted funds for a feasibility study, it Is necessary to elicit an estimate from you as to the cost of developing a project scope as well as the timing. Cordially, RXEslj Ralph L. Harding Jr. President SPI23265