Document qd4Qx1d20NJ64RL6DKLQv7gX5

5-A* Wv \3 ?* ( 0 N J) 5TABUSH 0 iaC< E. I. du Pont de N emours & C ompany IN CO R P O R A TED W il m in g t o n . D elaw are 19898 POLYMER PRODUCTS DEPARTMENT EXPERIMENTAL STATION PERSONAL AND CONFIDENTIAL cc : A. J. Dahl B. w. Kar rh L. J. Papa Pral File I.C. - 353 - Nil 400 - 269 _A/2. 2 < 2 4 - 51! July 24, 1981 DR. D. 0. INSLEE SPRUANCE TEXTILE FIBERS RICHMOND, VA ANALYSIS OF BLOOD SAMPLES FOR PERFLU0R00CTAN0ATE (Job No. 811-601; PRAL Nos. 81-2958-2959; Notebook Nos, E22514.E26238) As requested in your letter of 7/20/81 to L. J. Papa, the 2 blood samples submitted then have been analyzed for perfluorooctanoate (Cg) . Results and sample identification are given in the attached table. As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10/1 relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of % 0.004 ppm which can be distinguished from the reagent background but not well quantitated. Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. W. Raines or L. F. Percival. S/i'l! m 1'2 ^ S. S. Stafford Attachment jah Key Words: Perfluorooctanoic Acid Perfluorooc tanoate Blood Analysis GC Thr-f- p wo'lr* '<*f-.nor w** r* ri 000110 '* EXP000044 E ID713858 / TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a_X Sample PRAL No. Date Sampled 81-2958 6/9/31 81-2959 7/6/81 P.R.No 1286 Name GC Analysis__ Date Analvzed 7/15/81 7/15/81 ____________ 0 ilL*_ V Z P/g bloc'. 0.008 n.d . (a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard. (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit for quantitation is 0.007 pgF/g. The detection limit is a . 0.004 pgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [cg ] < 0.004 ppm. which cannot be distinguished from reagent background. ^ 000111 REDACTED* EXP000045 EID713859