Document qao1OJVREX1rJ72LN820n0VBE

Figure 1 Relationship between log red cell ALAD activity and blood lead concentration, female dogs. Data obtained in previous study (11). Calculated regression: log y = a + bx wmmmmm--m *: ALAD activity not measurable. These points, arbitrarily placed below the limit of sensitivity ........ - , were omitted in the calculation of the regression. DUP040002035 Figures 2, A and B The effect of whole blood dilution with plasma upon the normal red cell ALAD activity. A: Optical density (O.D.), on linear scale, vs. percent of blood contained in sample. Calculated Regression: y = a + bx mmm--m--m + 95% confidence limits: ------------------ B: Log optical density vs. percent of blood contained in sample. Curve fitted to data "by eye." DUP040002036 Figures 3, A and B The effect of lead-containing blood on the red cell ALAD activity of normal blood. A: Units of ALAD activity, or linear scale, versus percent of normal blood contained in sample. Calculated regression, y = a + bx : ALAD activity not measurable. Not included in calculation of regression. B. Log units ALAD activity versus percent of normal blood contained in samples. Curve fitted to data "by eye." : ALAD activity not measurable. Arbitrarily placed below limit of sensitivity ---------------- DUP040002037 Figure 4, a Observed ALAD activity of mixtures of normal and lead-containing bloods versus predicted values. Calculated regression y= a + bx + 95% confidence limits DUP040002038 Figure 4, B Observed blood lead concentration and ALAD activity of mixtures of normal and lead-containing bloods versus values predicted by simple dilution: Calculated blood lead regression .................................. Calculated ALAD regression Individual datum points: blood lead concentration o ALAD activity a DUP040002039 Figures 5, A and B Red cell ALAD activity of mixtures of normal and lead-containing bloods versus resultant lead concentration of the mixtures. A. Units of ALAD activity, a linear scale, versus blood lead concentration. Calculation regression : ALAD activity not measurable. Arbitrarily positioned below sensitivity limit ----------------. Data not included in calculation of regression. B. Log units of ALAD activity versus blood lead con centration. : ALAD activity not measurable. Arbitrarily positioned below sensitivity limit ----------------- . Curve fitted to data "by eye," DUP040002040 Figure 6 Observed ALAD versus predicted ALAD: Regression calculated for values predicted by simple dilution "Ideal" regression, y = x, for all values of x Individual datum points for prediction of ALAD according to the equation log y = 1.549 - 0.01908 x unmixed samples DUP040002041