Document qake1aVREmZvkebJ6XE4YdByM

AR226-2757 Fr " PONT USE ONLY E. l. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19/11 HASKELL LABORATORY REPORT NO. 1005-80 Study initiated/Completed 10/'/80 - 10/9/80 Material Submitted by rolymer Products Dept, Washington Works Parkersburg, V/V EYE IRRITATION TEST IN RABBITS Procedure: One tenth milliliter of undiluted test material was placed i n t o ^ the right conjunctival sac of each of 2 male New Zealand Whi.eraobits. Afte* 20 seconds, 1 treated eye was washed with tap water for 1 minute. The .reated eye of the other rabbit was not washed. Observations of the cornea, iris^anu conjunctiva were ms.de with an ophthalmoscope at 1 and 4 hours, and at x, and 3 days; Fluor-i-strlp stain and a slit-lamp biomicroscope were use a examinations after the day of treatment. . Results Dose 0.1 ml Treatment Not Washed 0.1 ml Washed Cornea Ocular Effects Iris Conlunctiva . General area of slight clouding at 1 hr; decreas ing to a small area at 4 hr ' No involve ment. Redness: None. Swelling:Slight 1-4 hr, Discharge:MiId at 4 hr. Smal.' area of slight clouding at 1 hr. decreasing to a local area 4 hr-1 day. No involve ment. Redness: None. SwellingiSlight 1-4 Discharge:None. Company SanWzed. Does not contain TSCA CBt -1 ...... . Nn---- - SSHr.Suuuaryt W = a U8ed sllghr ii=Md y. In an aya stud and pronpaly .an corneal clouding and slight conjunctivitis. Both -nsheu anu were normal 2 days after treatment. This compound may produce slight to mild eye irritation, eye contact, flush with copious amounts of water. In the event of Purity: Contaminants: Synonyms : Report by: S' J Lynn S. Silber Technician Approved by: Gerald L. Kennedy Chief, Acute Investigations Section LSS:jrg Study Director: 0 L. Dashiell date issued:_December 9, 1980 feport 5-80 | - 2- company Sanitized. Does not contain TSCA CBI