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AR226-3187 DuPont-4739 TRADE SECRET Study Title H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 4 o f 5 Laboratory Project ID: DuPont-4739 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) Author: Don A. Delker, Ph.D. Study Completed on: October 23,2001 Performing Laboratory: E I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 MWork Request Number: MService Code Numbers Sponsor Study Number: B fjp p w f Smftfeedl, Does not com* ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX L (CONTINUED) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS 938 Company SanK!ze& Dees m l eonfaln TSGA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings ____ 641234 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : . ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 939 Sew pay SmWzed. Does not confato TSCA Cl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641237 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. UTERUS : DILATATION, LUMEN, minimal. NOSE : .. ' DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 641237 Continued on the next page .... 940 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641237 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641256 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS,' HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, - FEMUR/KNEE JOINT, STERNUM, NOSE 641256 Continued on the next page .... 941 Setnpamf Saraltked, Dees net eentaln TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641256 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 641259 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641259 Continued on the next page .... 942 Sanitized Dm s p-j?&; fefe Tse. ei! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641259 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. . No Microscopic Abnormality Observed : THYROID GLAND, NOSE 641264 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS; MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : . INFLAMMATION, SUBACUTE/CHRONIC, mxnimal 641264 Continued on the next page --- 943 Company Sanitized. Does not contain r SCA a H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641264 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. 641275 No Microscopic Abnormality Observed : NOSE Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal 641275 Continued on the next page .... 944 snptsnsr Sanitized. Does not contain TS-^A H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641275 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. UTERUS : DILATATION, LUMEN, mild. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 945 !nof cti*tan jug H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641278 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, . ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : ` INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 946 Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641279 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM' PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE,'SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : .. . INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. PARATHYROID GLANDS : NOT PRESENT. 641279 Continued on the next page .... 947 C"mpa* *"*" * not < * * , tsca R H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641279 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, . PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641282 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS,' HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, - FEMUR/KNEE JOINT, STERNUM, NOSE 641282 Continued on the next page .... 948 C0mwnr no, contain T8CA - H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641282 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. 641299 No Microscopic Abnormality Observed : NOSE Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : SPLEEN : DISCOLORATION, BROWN. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641299 Continued on the next page 949 gjoupangrHanitigedLDoes notcontain TSC CBt Sanitized. Doe ___ . .. _ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641299 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, minimal. UTERUS : . DILATATION, LUMEN, minimal. NOSE : .. . DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 950 i sn * <n H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641300 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : ' INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : .n INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 641300 Continued on the next page .... gSaBa^aagSaaSfed, Etes 951 sonSafc TSQA CBt onspany Smffeed. B@s not eonfan TSi H-24616: Subchronic Toxicity DuPont-4739 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________ _____________-- -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females____ Animal Ref Microscopic & Macroscopic Findings 641300 Continued from previous page Histopathology NO "kidS s^ loS s! 1^ ? sX S S ! muscle, spleen. aorta. BRAIN SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, p S S i / S S ; EYE(S) WITH OPTIC NERVE, SKIN MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641301 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : N `L ^ r ^ D M ^ ' S o s T S S r S K E L E T R L MSCLE. SPLEEN, AORTA BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM i l e u m ! PANCREAS, CECUM, COLON, RECTUM, m e s e n t e r i c l y m p h NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGU , PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMAR GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641301 Continued on the next page .... H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641301 Continued from previous page Histopathology : LIVER : n INFLAMMATION, SUBACUTE/CHRONIC, minimal. 641314 No Microscopic Abnormality Observed : THYROID GLAND, NOSE Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy ' Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : ., . INFLAMMATION, SUBACUTE/CHRONIC, minimal 641314 Continued on the next page .... 953 .Mipan^ Sanitized. Boss not contain TSCACB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641314 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : ... DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, . STERNUM, BONE MARROW 641326 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM,. ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 641326 Continued on the next page .... 954 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641326 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 955 Hwfftad. Does not contain TSCACBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641327 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : .. . DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 641327 Continued on the next page .... 956 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641327 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641352 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, - FEMUR/KNEE JOINT, STERNUM, NOSE 641352 Continued on the next page .... 957 mpamj? Sanitized. Does not contain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641352 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 641356 Found Dead Duration of dosing-days: 121 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : BRAIN : MIXED GLIOMA [M]. [B]=BENIGN, [M]=MALIGNANT 641356 Continued on the next page .... 958 spauf Sanitized, Does not contain TSCA Cb'| H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641356 Continued from previous page Histopathology : ILEUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. CECUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. COLON : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. THYROID GLAND : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. EYE(S ) WITH OPTIC NERVE : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. SKIN : NOT PRESENT. MAMMARY GLAND (FEMALE) : NOT PRESENT. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, PANCREAS, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 959 CMwpanf Sanitized. Does not contain TSC CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641366 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 960 Company Sanitized. Doe contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641377 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : . LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 961 ^ P a n y Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641380 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. SCIATIC NERVE : NOT PRESENT. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. ' NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 641380 Continued on the next page .... 962 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641380 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641385 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS,' HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641385 Continued on the next page 963 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641385 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 641387 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, .COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641387 Continued on the next page 964 IkMqpany Sanitized. Does no! contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641387 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. . 641390 No Microscopic Abnormality Observed : NOSE Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE - 641390 Continued on the next page 965 S M itte l m m not coniata TSCACl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641390 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, mild. PARATHYROID GLANDS : NOT PRESENT. EYE{S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. NOSE : .n DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 966 l*0a?panf Sanitized. Does not contain TSCA CbI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641395 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUm ! PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : . INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN-CLEFT, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 967 Company Sanitized. Does not contain TSCACBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 1000 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641399 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : ,,,,,, LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : .n INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. No Microscopic Abnormality Observed : NOSE 968 Banpanr Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX M REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi MALE RATS 969 Company Sanitized. Does no! contain TSCACB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________ REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi MALE RATS EXPLANATORY NOTES Notes: Test Days 7 1 - 8 5 = Cohabitation period DuPont-4739 970 Sanitized. Does net contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Px MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 641174 641107 641072 641053 641168 71 78 85 92 100 660.5 568.4 500.1 547.1 495.4 651.9 501.5 547.3 528.5 464.4 638.4 521.5 529.2 653.6 494.6 492.4 517.3 495.1 569.3 527.7 668.9 592.7 508.7 562.3 507.2 684.7 510.9 568.1 541.7 484.6 655.5 540.4 535.1 665.6 500.9 508.8 518.4 501.2 584.3 537.8 685.4 597.2 513.9 579.1 518.6 697.4 520.0 574.7 552.7 490.8 671.2 558.5 545.6 686.7 512.5 515.6 534.1 510.0 597.1 552.6 675.2 595.7 520.3 594.4 531.5 719.1 528.4 589.4 561.5 501.0 696.9 572.9 558.8 706.5 535.1 528.5 556.7 512.7 600.5 561.0 681.6 588.8 522.2 614.3 533.5 736.4 532.6 606.1 560.1 502.9 716.1 589.1 563.0 714.0 536.0 534.2 568.0 527.6 633.6 573.5 971 Sanitized. Does not contain TSka H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi MALE RATS GROUP: III-O DOSE: 50 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 641103 641181 641171 641111 641062 641156 641173 641121 641074 641191 71 78 85 92 100 555.4 501.6 559.5 572.0 459.2 563.5 482.5 484.7 516.8 534.7 622.9 559.6 598.6 515.3 524.2 576.3 556.4 524.6 582.5 570.1 583.1 451.6 567.0 586.5 464.5 563.3 508.1 497.9 522.4 548.3 616.3 579.2 617.5 522.0 536.6 587.9 563.9 552.9 600.3 569.2 594.2 495.0 577.3 597.4 484.3 564.5 513.9 502.5 538.4 554.7 627.7 584.5 622.4 524.3 539.7 607.9 574.3 557.9 610.3 562.3 610.7 520.3 602.6 595.8 498.3 578.3 507.5 497.6 546.1 563.1 647.1 597.2 640.6 532.1 551.1 620.3 592.7 575.1 569.0 568.7 609.3 537.2 604.2 596.6 507.7 591.1 518.2 505.1 560.3 573.9 651.3 598.4 652.5 523.5 560.3 619.0 601.9 592.2 600.9 572.7 972 owpwif Sanitized Ones not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pj. MALE RATS GROUP: V --0 DOSE: 250 MG/KG/DAY TEST DAYS: - ANIMAL NUMBER 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 641124 641082 641151 641195 641122 641184 641142 641120 641179 641164 71 78 85 92 100 578.9 506.7 495.0 454.3 504.0 531.1 581.3 532.0 528.0 579.0 594.3 486.3 519.8 550.3 538.9 505.4 476.4 603.5 583.4 560.1 600.0 535.8 474.0 459.6 526.7 546.6 605.5 546.3 541.5 606.9 601.6 493.5 528.2 565.6 551.0 514.5 478.6 612.3 604.1 576.5 614.0 543.1 483.9 477.0 524.3 542.4 601.7 565.9 544.2 610.9 618.3 499.8 538.5 576.8 558.7 524.5 476.4 630.1 605.0 593.3 639.4 558.6 501.7 478.1 531.9 552.4 617.4 566.3 564.8 626.7 636.2 507.3 547.3 590.3 553.5 520.3 487.5 641.7 620.7 613.1 641.1 565.1 522.9 483.8 523.5 564.2 612.7 559.4 579.2 643.6 652.6 514.7 562.9 599.6 565.4 517.2 502.6 647.2 648.9 622.3 973 ComPanr Sanitized, Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pj. MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 641152 641182 641150 641211 641145 71 78 85 92 100 558.4 449.6 459.6 458.1 445.9 528.2 402.4 519.9 549.8 489.9 498.2 497.1 589.1 510.7 563.7 468.7 447.7 433.5 430.4 494.7 567.9 458.8 476.0 465.2 455.9 536.3 402.5 532.5 557.9 497.2 495.9 521.1 621.4 527.2 579.0 491.8 451.9 442.4 446.8 518.6 556.4 479.1 483.5 462.6 470.5 544.9 408.4 534.6 571.1 503.1 514.8 522.5 639.1 547.3 535.5 500.4 459.0 441.3 455.2 504.2 565.8 489.6 487.6 469.2 491.6 564.0 420.3 550.3 589.2 504.5 522.7 535.5 642.3 554.9 564.1 517.6 474.9 461.9 465.8 519.7 592.1 498.1 501.5 476.8 501.7 557.8 409.0 558.1 592.2 520.2 529.8 524.9 646.3 571.6 583.7 525.9 480.5 463.1 473.6 526.8 974 Cwpan]f Sanitized. Does not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX N REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS 975 Company Sanitized. Does not contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS EXPLANATORY NOTES Notes: Test Days 71 - 85 = Cohabitation period DuPont-4739 b 976 H-24616: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: I--0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 641174 641107 641072 641053 641168 71-78 78-85 85-92 92-100 71-100 8.4 24.3 8.6 15.2 11.8 32.8 9.4 20.8 13.2 20.2 17.1 18.9 5.9 12.0 6.3 16.4 1.1 6.1 15.0 10.1 16.5 4.5 5.2 16.8 11.4 12.7 9.1 6.6 11.0 6.2 15.7 18.1 10.5 21.1 11.6 6.8 15.7 8.8 12.8 14.8 -10.2 -1.5 6.4 15.3 12.9 21.7 8.4 14.7 8.8 10.2 25.7 14.4 13.2 19.8 22.6 1 2 .9 22.6 2.7 3.4 8.4 6.4 -6.9 1.9 19.9 2.0 17.3 4.2 16.7 -1.4 1.9 19.2 16.2 4.2 7.5 0.9 5.7 11.3 14.9 33.1 12.5 21.1 20.4 22.1 67.2 38.1 84.5 31.1 58.8 31.6 38.5 77.7 67.6 33.8 60.4 41.4 41.8 50.7 32.5 64.3 45.8 977 Sanitized. Boos not eoniaSn TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: III-O DOSE: 50 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 641103 641181 641171 641111 641062 641156 641173 641121 641074 641191 71-78 78-85 85-92 92-100 71-100 27.7 -50.0 7.5 14.5 5.3 -0.2 25.6 13.2 5.6 13.6 -6.6 19.6 18.9 6.7 12.4 11.6 7.5 28.3 17.8 -0.9 11.1 43.4 10.3 10.9 19.8 1.2 5.8 4.6 16.0 6.4 11.4 5.3 4.9 2.3 3.1 20.0 10.4 5.0 10.0 -6.9 16.5 25.3 25.3 -1.6 14.0 13.8 -6.4 -4.9 7.7 8.4 19.4 12.7 18.2 7.8 11.4 12.4 18.4 17.2 -41.3 6.4 -1.4 16.9 1.6 0.8 9.4 12.8 10.7 7.5 14.2 10.8 4.2 1.2 11.9 -8.6 9.2 -1.3 9.2 17.1 31.9 4.0 53.9 35.6 44.7 24.6 48.5 27.6 35.7 20.4 43.5 39.2 28.4 38.8 53.9 8.2 36.1 42.7 45.5 67.6 18.4 2.6 978 ^owspany Sanitized. Does not contain TSCACB ! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: V-0 DOSE: 250 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 641124 641082 641151 641195 641122 641184 641142 641120 641179 '641164 71-78 78-85 85-92 92-100 71-100 21.1 29.1 -21.0 5.3 22.7 15.5 24.2 14.3 13.5 27.9 7.3 7.2 8.4 15.3 12.1 9.1 2.2 8.8 20.7 16.4 14.0 7.3 9.9 17.4 -2.4 -4.2 -3.8 19.6 2.7 4.0 16.7 6.3 10.3 11.2 7.7 10.0 -2.2 17.8 0.9 16.8 25.4 15.5 17.8 1.1 7.6 10.0 15.7 0.4 20.6 15.8 17.9 7.5 8.8 13.5 -5.2 -4.2 11.1 11.6 15.7 19.8 1.7 6.5 21.2 5.7 -8.4 11.8 -4.7 -6.9 14.4 16.9 16.4 7.4 15.6 9.3 11.9 -3.1 15.1 5.5 28.2 9.2 62.2 58.4 27.9 29.5 19.5 33.1 31.4 27.4 51.2 64.6 58.3 28.4 43.1 49.3 26.5 11.8 26.2 43.7 65.5 62.2 979 Company Sanitized. Does not contain tsca CB1! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 641152 641182 641150 641211 641145 71-78 78-85 85-92 92-100 71-100 9.5 9.2 16.4 7.1 10.0 8.1 0.1 12.6 8.1 7.3 -2.3 24.0 32.3 16.5 15.3 23.1 4.2 8.9 16.4 23.9 -11. 5 2 0 .3 7. 5 -2. 6 14. 6 8 .6 5. 9 2 .1 13. 2 5. 9 18. 9 1 .4 17, 7 20 1 -43 .5 8 ,6 7 .1 -1 .1 8 .4 -14 .4 9.4 10.5 4.1 6.6 21.1 19.1 11.9 15.7 18.1 1.4 7.9 13.0 3.2 7.6 28.6 17.2 15.9 20.6 10.6 15.5 26.3 8.5 13.9 7.6 10.1 -6.2 -11.3 7.8 3.0 15.7 7.1 -10.6 4.0 16.7 19.6 8.3 5.6 1.2 7.8 7.1 33.7 48.5 41.9 18.7 55.8 29.6 6.6 38.2 42.4 30.3 31.6 27.8 57.2 60.9 20.0 57.2 32.8 29.6 43.2 32.1 980 Company Sanitised. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX O REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION 981 Gom pm j Sanitized. Does not contain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes ' a Dam delivered prior to collection o f day 21 body weight. b No litter was delivered; data were excluded from statistical analysis. c No gestation data were collected since no plug was observed; however, a litter was delivered. d No gestation data were collected since no plug was observed; no litter was delivered. . Abbreviations -- = No Data 982 ompany Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358* 641389* 641317e 641255 641403 641388 641261 641306 641349e 641346 641308 641289 0 7 14 21 277.4 294.9 324.8 325.8 274.0 288.1 322.6 331.2 300.7 297.7 -- 302.8 319.2 354.2 287.5 289.3 -- 321.8 281.7 300.8 289.9 330.3 356.9 352.1 309.6 318.0 345.4 360.4 309.2 309.9 -- 327.2 362.1 376.0 310.4 329.8 -- 359.8 306.4 330.4 309.3 366.7 383.8 381.6 331.5 350.2 380.0 405.4 314.4 317.2 -- 347.7 395.8 425.9 339.9 356.1 -- 382.0 342.6 366.9 __ a 461.3 450.2 455.0 430.1 438.3 484.2 498.0 311.7 314.9 -- 447.4 507.4 __ a 420.6 450.4 -- 473.5 419.0 441.5 983 Company Sanitized. Does not contain TSCACBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY GESTATION DAYS : ANIMAL NUMBER 641378 641263 641297 641304 641274* 641351 641272 641258 641276* 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 0 7 14 21 336.0 278.3 311.4 315.9 350.5 276.4 290.4 339.7 376.6 292.7 292.3 310.4 335.2 286.1 283.6 308.5 330.4 298.0 388.0 306.9 372.8 298.0 347.8 347.7 362.8 293.1 317.5 362.5 393.4 306.8 313.6 337.9 350.7 316.9 320.5 322.9 366.7 325.0 422.7 339.8 405.4 326.3 378.7 365.3 363.2 320.2 346.3 393.1 411.5 339.9 331.8 364.9 386.3 342.3 353.0 342.7 405.1 357.0 461.3 368.8 512.7 410.0 483.9 460.8 367.2 421.4 437.9 __ a 401.2 442.4 390.8 469.8 471.0 429.6 441.2 430.1 517.5 441.3 532.9 457.4 984 Sfflfflpasy Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641271 641280^ 641252k 641386^ 641277 641233 641238 641235 641392 641360 641381k 641333d 641239 641228k 641334 641347 641367k 641303 641339 641316 0 7 14 21 299.7 282.6 311.4 288.3 318.8 311.3 298.4 253.8 310.2 273.2 334.3 -- 333.1 334.9 285.0 315.2 350.5 286.2 321.0 293.1 319.4 313.4 326.0 315.8 352.5 343.5 312.7 282.8 327.8 297.8 351.5 -- 353.3 361.6 314.6 351.3 340.1 308.0 349.0 319.2 346.3 340.2 320.1 338.6 390.5 386.4 345.4 304.4 364.3 323.2 361.2 -- 386.0 389.4 342.4 394.3 350.5 329.0 378.0 349.3 448.1 334.2 328.2 317.6 489.0 480.7 438.2 362.1 440.3 408.3 363.3 -- 487.2 387.4 431.7 490.2 349.5 417.4 472.4 443.2 985 Company Sanitized. Does not contain TSC CB! H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS : ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242* 641284 641230 641273* 641296 641248 641370 641243 641329 0 7 14 21 298.6 291.3 267.6 264.9 321.2 256.8 281.2 274.4 311.5 348.6 301.9 343.9 304.4 279.6 286.7 279.5 346.4 310.9 312.0 264.4 319.8 312,0 281.4 279.3 333.2 292.7 309.5 297.6 330.6 369.1 340.9 336.9 336.5 297.2 318.6 295.3 373.1 337.5 335.4 281.6 354.7 349.2 302.5 311.0 374.7 328.7 336.6 317.2 362.1 411.8 373.2 346.8 365.3 325.9 329.4 329.9 409.0 370.3 372.3 313.0 451.3 443.6 368.9 390.5 471.9 406.9 437.4 405.7 476.1 522.0 472.8 346.9 485.1 408.0 320.0 421.7 519.2 444.3 470.0 409.1 986 Cnpan^ Sanitized. Does no? contain TSCA CEP H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX P REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION 987 ompany Sanitized. Does not contain TSC CB' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a Dam delivered prior to collection of day 21 body weight. b No litter was delivered; data were excluded from statistical analysis. c No gestation data were collected since no plug was observed; however, a litter was delivered. d No gestation data were collected since no plug was observed; no litter was delivered. Abbreviations -- = No Data 988 eomPany Sanitized. Does not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358-h* 641389^ 641317e 641255 641403 641388 641261 641306 641349e 641346 641308 641289 0-7 7-14 14-21 0-21 12.5 35.4 32.1 26.3 35.6 29.9 22.8 29.2 8.5 12.2 -- 24.4 42.9 21.8 22.9 40.5 -- 38.0 24.7 29.6 19.4 36.4 26.9 29.5 21.9 32.2 34.6 45.0 5.2 7.3 ______ 20.5 33.7 49.9 29.5 26.3 -- 22.2 36.2 36.5 __ a 94.6 66.4 73.4 98.6 88.1 104.2 92.6 -2.7 -2.3 -- 99.7 111.6 __ a 80.7 94.3 -- 91.5 76.4 74.6 __ a 166.4 125.4 129.2 156.1 150.2 161.6 166.8 11.0 17.2 -- 144.6 188.2 __ a 133.1 161.1 -- 151.7 137.3 140.7 989 C " W V D" ' T S C fl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641378 641263 641297 641304 6412743 641351 641272 641258 641276-k 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 0-7 7-14 14-21 0-21 36.8 19.7 36.4 31.8 12.3 16.7 27.1 22.8 16.8 14.1 21.3 27.5 15.5 30.8 36.9 14.4 36.3 27.0 34.7 32.9 32.6 28.3 30.9 17.6 0.4 27.1 28.8 30.6 18.1 33.1 18.2 27.0 35.6 25.4 32.5 19.8 38.4 32.0 38.6 29.0 107.3 83.7 105.2 95.5 4.0 101.2 91.6 __ a -10.3 102.5 59.0 104.9 84.7 87.3 88.2 87.4 112.4 84.3 71.6 88.6 176.7 131.7 172.5 144.9 16.7 145.0 147.5 24.6 149.7 98.5 159.4 135.8 143.5 157.6 121.6 187.1 143.3 144.9 150.5 990 Company Sanitized. Does not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641271 641280* 641252* 641386* 641277 641233 641238 641235 641392 641360 641381* 6413333 641239 641228* 641334 641347 641367* 641303 641339 641316 0-7 7-14 14-21 0-21 19.7 30.8 14.6 27.5 33.7 32.2 14.3 29.0 17.6 24.6 17.2 -- 20.2 26.7 29.6 36.1 -10.4 21.8 28.0 26.1 26.9 26.8 -5.9 22.8 38.0 42.9 32.7 21.6 36.5 25.4 9.7 -- 32.7 27.8 27.8 43.0 10.4 21.0 29.0 30.1 101.8 -6.0 8.1 -21.0 98.5 94.3 92.8 57.7 76.0 85.1 2.1 -- 101.2 -2.0 89.3 95.9 -1.0 88.4 94.4 93.9 148.4 51.6 16.8 29.3 170.2 169.4 139.8 108.3 130.1 135.1 29.0 -- 154.1 52.5 146.7 175.0 -1.0 131.2 151.4 150.1 991 w p a i* Sanitized, Does not contain TSCA f"r" Company Sanitized. Does not contain TSi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242* 641284 641230 641273* 641296 641248 641370 641243 641329 0-7 7-14 14-21 0-21 21.2 20.7 13.8 14.4 12.0 35.9 28.3 23.2 19.1 20.5 39.0 -7.0 32.1 17.6 31.9 15.8 26.7 26.6 23.4 17.2 34.9 37.2 21.1 31.7 41.5 36.0 27.1 19.6 31.5 42.7 32.3 9.9 28.8 28.7 10.8 34.6 35.9 32.8 36.9 31.4 96.6 94.4 66.4 79.5 97.2 78.2 100.8 88.5 114.0 110.2 99.6 0.1 119.8 82.1 -9.4 91.8 110.2 74.0 97.7 96.1 152.7 152.3 101.3 125.6 150.7 150.1 156.2 131.3 164.6 173.4 170.9 3.0 180.7 128.4 33.3 142.2 172.8 133.4 158.0 144.7 992 ompany Sanitized. Does no? contain t s c a cp H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX Q REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING LACTATION 993 Sowspamy HaniSlied. Does noeonSaln SC If H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes i a No litter was delivered; therefore, no lactation data were collected. b Weighing error. Data excluded from statistical analysis. c Animal was found dead on lactation day 13. All pups were cannibalized before lactation day 7. Animal was excluded from statistical analysis. Abbreviations = No Data 994 Smspany Sanitized. Does not contain TSCACBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY LACTATION DAYS : ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358a 641389a 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 0 7 14 21 295.3 356.4 394.4 369.9 313.9 314.5 367.4 388.7 -- -- 357.2 342.1 372.3 382.5 333.1 335.4 354.6 358.3 308.0 348.3 292.2 361.0 362.3 367.0 299.1 335.9 354.4 369.3 ______ 358.5 342.9 378.8 374.0 339.9 335.3 353.6 362.2 320.6 349.9 315.7 372.3 361.6 380.7 350.9 348.8 344.9 386.8 ______ 359.2 359.3 420.8 395.3 346.3 356.5 393.3 365.3 346.2 362.3 293.4 353.9 354.4 374.2 317.2 334.7 334.8 360.2 -- 360.7 346.8 389.8 384.5 335.2 340.0 361.9 357.6 340.5 352.4 995 Company Sanitised Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pj. FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY LACTATION DAYS : ANIMAL NUMBER 641378 641263 641297 641304 641274a 641351 641272 641258 641276a 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 0 7 14 21 373.6 321.8 376.7 386.1 -- 317.2 312.4 340.4 -- 335.1 312.4 --b 372.7 328.6 337.8 328.8 378.5 340.4 442.6 354.1 376.7 328.5 365.8 341.7 312.9 332.4 354.7 328.1 331.3 360.5 343.0 306.0 337.3 321.4 367.6 335.1 419.9 336.5 403.9 345.7 381.7 355.4 338.5 328.9 392.3 356.8 345.1 376.0 360.4 326.0 342.1 340.5 410.8 351.1 404.5 357.4 373.5 323.1 350.7 339.6 329.3 308.0 376.5 335.5 342.6 366.1 340.7 318.0 322.7 340.5 396.7 349.3 397.1 346.2 996 Company Smtxe, Does not ontan TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392e 641360 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 0 7 14 21 329.0 -- -- 392.8 361.1 333.4 301.4 342.6 299.7 -- 368.5 301.0 360.8 315.7 353.4 331.1 348.4 -- -- 377.8 351.8 318.1 302.0 329.3 322.8 -- 369.8 321.9 374.2 321.0 381.3 348.1 355.5 -- -- 379.7 374.8 342.6 322.6 338.3 -- 378.4 343.5 385.6 325.6 389.0 341.2 343.1 _--_ _---- 355.4 356.9 324.0 319.1 326.7 388.2 324.0 361.0 318.0 367.5 353.8 997 Company Sanitized. Does no?contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242a 641284 641230 641273a 641296 641248 641370 641243 641329 0 7 14 21 339.5 328.3 297.5 297.1 373.2 290.3 326.2 300.4 376.0 393.6 343.5 -- 358.9 320.7 -- 307.9 401.4 352.8 363.0 292.6 351.5 331.3 300.2 311.2 362.6 284.7 286.6 310.9 364.0 393.6 347.8 358.9 313.8 324.3 390.2 365.0 353.8 322.7 378.1 328.1 312.8 331.7 384.8 335.4 337.2 334.9 379.6 408.0 375.2 386.0 321.0 328.9 391.9 386.3 363.0 330.2 360.9 335.0 300.0 310.7 367.4 302.3 320.9 318.3 349.5 393.3 355.5 357.6 318.8 313.1 355.3 357.2 374.3 315.3 998 Company Sanitized Does not contain TSGA C H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX R REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING LACTATION 999 Company Sanitized. Does not contain TSCGBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No litter was delivered; therefore, no lactation data were collected. b Weighing error. Data excluded from statistical analysis. c Animal was found dead on lactation day 13. All pups were cannibalized before lactation day 7. Animal was excluded from statistical analysis. Abbreviations -- = No Data 1000 * W ' ***- Doe. not contain TSCACB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358a 641389a 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 0-7 7-14 14-21 0-21 -3.1 4.6 -32.1 -2.9 -14.8 21.4 -13.0 -19.4 -- -- 1.3 0.8 6.5 -8.5 6.8 -0.1 - 1.0 3.9 12.6 1.6 23.5 11.3 -0.7 13.7 51.8 12.9 -9.5 17.5 III 0.7 16.4 42.0 21.3 6.4 21.2 39.7 3.1 25.6 12.4 -22.3 -18.4 -7.2 -6.5 -33.7 -14.1 -10.1 -26.6 ______ 1.5 -12.5 -31.0 -10.8 -11.1 -16.5 -31.4 -7.7 -5.7 -9.9 -1.9 -2.5 -40.0 4.3 3.3 20.2 -32.6 -28.5 -- 3.5 4.7 17.5 2.0 2.1 4.6 7.3 -0.7 32.5 4.1 "S 1001 Company Sanitized. Does not coniaiz, 7>'.,.\- H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641378 641263 641297 641304 641274a 641351 641272 641258 641276a 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 0-7 7-14 14-21 0-21 3.1 6.7 -10.9 -44.4 -- -4.3 20.0 14.3 -- -7.0 18.9 __ b -29.7 -22.6 -0.5 -7.4 -10.9 -5.3 -22.7 -17.6 27.2 17.2 15.9 13.7 -- 25.6 -3.5 37.6 -- 28.7 13.8 15.5 17.4 20.0 4.8 19.1 43.2 16.0 -15.4 20.9 -30.4 -22.6 -31.0 -15.8 -- -9.2 -20.9 -15.8 -- -21.3 -2.5 -9.9 -19.7 -8.0 -19.4 0.0 -14.1 -1.8 -7.4 -11.2 -0.1 1.3 -26.0 -46.5 -- 12.1 -4.4 36.1 -- 0.4 30_._2V_ -32.0 -10.6 -15.1 11.7 18.2 8.9 -45.5 -7.9 1002 Company Sanitized. Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641271 641280a 641252a 641386a 641277 641233 641238 641235 641392e 641360 641381a 641333a 641239 641228a 641334 641347 641367a 641303 641339 641316 0-7 7-14 14-21 0-21 19.4 -- -- -- -15.0 -9.3 -15.3 0.6 -13.3 23.1 -- -- 1.3 -- 20.9 13.4 -- 5.3 27.9 17.0 7.1 -12.4 14.1 1.9 23.0 24.5 20.6 15.5 -- 8.6 ______ 21.6 11.4 4.6 7.7 -6.9 -24.3 -17.9 -18.6 -3.5 -11.6 -- 9.8 -- -19.5 -24.6 -7.6 -21.5 12.6 -37.4 -4.2 -9.4 17.7 27.0 -- 19.7 -- 23.0 0.2 2.3 14.1 22.7 1003 Company Santtfzed. Does no! contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pj. FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242a 641284 641230 641273a 641296 641248 641370 641243 641329 0-7 7-14 14-21 0-21 12.0 3.0 2.7 14.1 -10.6 -5.6 -39.6 10.5 -12.0 0.0 4.3 -- 0.0 -6.9 -- 16.4 -11.2 12.2 -9.2 30.1 26.6 -3.2 12.6 20.5 22.2 50.7 50.6 24.0 15.6 14.4 27.4 27.1 7.2 4.6 1.7 21.3 9.2 7.5 -17.2 6.9 -12.8 -21.0 -17.4 -33.1 -16.3 -16.6 -30.1 -14.7 -19.7 -28.4 -2.3 -15.8 -36.6 -29.1 11.3 -14.9 21.4 6.7 2.5 13.6 -5.8 12.0 -5.3 17.9 -26.5 -0.3 12.0 -1.3 -2.0 5.2 -46.1 4.4 11.3 22.7 1004 Company Sanitized. Does not contain TSC CBI H-24616: Subchronic Toxicity . 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX S REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL DAILY FOOD CONSUMPTION BY Pi FEMALE RATS DURING GESTATION 1005 spanf Sanitized Does no! contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL DAILY FOOD CONSUMPTION BY Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter was delivered; data were excluded from statistical analysis. b No gestation data were collected since no plug was observed; however, a litter was delivered, c No gestation data were collected since no plug was observed; no litter was delivered. . d Weighing error; data were excluded from statistical analysis. Abbreviations -- = No data 1006 ^o^peny Sanitized. Does not contain TSCA OBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pi FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358s 641389s 641317* 641255 641403 641388 641261 641306 641349* 641346 641308 641289 0-7 7-14 0-14 23.0 26.1 25.6 24.5 23.0 23.3 24.0 30.1 19.7 21.1 -- 24.2 24.7 25.7 22.9 24.8 -- 27.5 25.3 24.0 22.7 29.6 29.9 29.5 24.3 27.2 27.1 33.2 20.3 20.1 -- 25.7 29.8 27.9 25.4 25.0 -- 27.9 26.9 26.4 22.9 27.8 27.8 27.0 23.7 25.3 25.6 31.7 20.0 20.6 -- 24.9 27.3 26.8 24.1 24.9 -- 27.7 26.1 25.2 1007 Cwnpwf Sanitized. Does not contain TSC CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Px FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641378 641263 641297 641304 641274s 641351 641272 641258 641276s 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 0-7 7-14 0-14 28. 2 23. 9 24. 1 26. 6 27. 2 20. 1 25. 7 24. 8 26..4 19.,7 22..0 26..5 24..9 22 .3 26 .4 22 .0 31 .1 24 .0 31 .1 27 .0 30. 1 26. 6 28. 2 26. 1 24. 0 22. 0 26. 4 29. 6 28..7 24..0 22..4 25..8 28..8 24,.5 28 .1 22 .4 33 .7 23 .6 33 .5 28 .1 29.2 25.2 26.1 26.4 25.6 21.1 26.0 27.2 27.6 21.9 22.2 26.1 26.8 23.4 27.3 22.2 32.4 23.8 32.3 27.6 1008 .Company Sanitized Dees not contain TSCA CB^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Px FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641271 641280a 641252a 641386a 641277 641233 641238 641235 641392 641360 641381a 641333e 641239 641228a 641334 641347 641367a 641303 641339 641316 0-7 7-14 0-14 21.1 24.3 23.9 21.0 24.9 25.5 22.0 21.0 23.4 20.4 27.0 -- 24.7 23.7 23.0 27.7 20.2 24.1 26.3 25.2 23.2 26.3 22.8 23.8 29.1 29.4 26.8 21.3 25.4 20.9 25.7 -- 26.8 29.4 __ d 29.6 31.0 24.2 28.1 25.9 22.2 25.3 23.4 22.4 27.0 27.4 24.4 21.1 24.4 20.6 26.4 -- 25.8 26.6 __ ( 28.7 25.6 24.2 27.2 25.6 1009 Company SanfOred, n** w* H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Px FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 0-7 7-14 0-14 21.0 25.8 20.3 18.4 22.6 25.0 23.1 20.7 24.9 27.6 24.9 20.6 23.9 20.3 24.7 21.2 27.4 28.0 23.6 21.7 25.3 28.4 20.3 22.2 25.7 25.6 24.3 19.2 26.0 29.2 25.8 22.9 24.8 22.8 25.5 22.0 31.0 25.6 27.2 23.5 23.2 27.1 20.3 20.3 24.1 25.3 23.7 20.0 25.5 28.4 25.4 21.7 24.4 21.5 25.1 21.6 29.2 26.8 25.4 22.6 1010 Gompfflf Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX T REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS ion Company Sanitized. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 ALOPECIA LEFT LEG(S) SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 108 SORE TAIL SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA RIGHT FRONT PAW(S) ALOPECIA RIGHT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 ALOPECIA RIGHT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 100 107 100 108 78 108 100 108 85 108 107 108 78 109 109 109 1012 ------------------- Ih CompanySanitized. Does not contain TSC * ^ Rl IB H h M ill. tifa to la 'i.ii A n f a ilii T e r * H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641174 641107 641072 641053 641168 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 1013 Company Sanitized. Does no! contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations 1 DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: III-O DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 641103 641181 641171 641111 641062 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 107 LUNG NOISE SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED ' SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 OBSERVED LAST DAY OBSERVED 78 107 85 85 78 109 1014 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: III-O DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION 641156 641173 641121 641074 641191 ALOPECIA RIGHT FRONT LEG(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 FIRST DAY LAST DAY OBSERVED OBSERVED 78 110 1015 Company Sanitized. Does net contain TSCA C9 ! H -24616: Subchronic Toxicity 90-D av Gavaee Studv in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: V -0 DOSE: 2 5 0 MG/KG/DAY ANIMAL NUMBER - OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 641124 641082 641151 641195 641122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED . SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 . 78 100 1016 Company Sanitized. Dees not contain TSCA cert H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: V-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641184 641142 641120 641179 641164 ALOPECIA LEFT FRONT LEG (S) SORE LEFT FRONT LEG (S ) SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 107 H O H O 110 1017 Company Sanitized. Does no? contain t s c a CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations , DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP : VII-0 DOSE : 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA LEFT FRONT PAW(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 78 108 78 108 78 78 85 109 1018 j&ompanjrSanRfeedL Does nnf contain rer# H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641152 641182 641150 641211 641145 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 110 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 110 85 110 1019 Company Sanitized. Does not contain TSCA OBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX U REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION 1020 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____________ _____ DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Notes This appendix includes only signs from rats that delivered a litter. 1021 Company Sanitized. Does not contain TSC CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641345 641236 641337 641328 641310 641324 641371 641332 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LEG(S ) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA ABDOMEN NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 0 21 21 21 1022 Company Sanitized. Does not contain TSCA C^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER ' OBSERVATION 641378 ALOPECIA RIGHT SIDE(S) 641263 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) 641297 NO ABNORMALITIES DETECTED 641304 NO ABNORMALITIES DETECTED 641351 NO ABNORMALITIES DETECTED 641272 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) 641258 NO ABNORMALITIES DETECTED 641350 ALOPECIA LEFT FRONT LEG(S) 641376 NO ABNORMALITIES DETECTED 641315 ' NO ABNORMALITIES DETECTED 641286 NO ABNORMALITIES DETECTED 641231 641338 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 641318 NO ABNORMALITIES DETECTED 641373 ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH HIND QUARTERS ALOPECIA BASE TAIL ALOPECIA ABDOMEN 641365 NO ABNORMALITIES DETECTED 641348 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) 641323 NO ABNORMALITIES DETECTED FIRST DAY LAST DAY OBSERVED OBSERVED 7 21 0 14 14 14 0 21 7 21 21 21 0 21 0 0 21 21 21 7 21 14 21 1023 Company Sanitized. Does not contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION GROUP: VI- 0 DOSE: ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641271 641277 641233 641238 641235 641392 641360 641239 641334 641347 641303 641339 641316 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED . NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) 0 21 0 21 7 21 14 21 21 21 21 1024 Company Sanitized. Does no! contain TSCA CO! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641284 641230 641296 641248 641370 641243 641329 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES' DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) ALOPECIA LEFT FRONT LEG(S) 7 21 14 21 0 21 21 21 7 21 21 21 7 21 14 21 1025 Company Sanitized. Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX V REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION 1026 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note This appendix includes signs from lactating rats only. 1027 Company Sanitized. Does not contain TSCA OBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER ' OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641345 641236 641337 641328 641310 641324 641371 641332 641317 641255 641403 641388 641261 641306 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 0 21 - 1028 Company Sanitized. Does not contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641349 641346 641308 641289 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA ABDOMEN ALOPECIA LEFT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 0 21 14 21 1029 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641378 641263 641297 641304 641351 641272 641258 641350 641376 641315 641286 641231 641338 ALOPECIA RIGHT SIDE(S) SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 126 ALOPECIA LEFT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES' DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 0 14 0 210 ll 210 0 21 1030 Company Sanitized. Does not contain TSCA CB. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641318 641373 641365 641348 641323 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH HIND QUARTERS ALOPECIA BASE TAIL ALOPECIA ABDOMEN SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 0 21 0 21 0 21 0 21 0 21 0 21 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641271 641277 641233 641238 641235 641392 641360 641239 641334 641347 641303 641339 641316 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 ALOPECIA BOTH FRONT LEG (S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 FOUND DEAD TEST DAY 107 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST' DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 124 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 114 0 21 0 21 0 210 21 13 13 0 21 0 21 0 21 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER ' OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641284 641230 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 116 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 115 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 117 0 21 0 21 0 21 0 21 14 21 1033 Compaq SanSffeed. B0es not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION 641296 641248 641370 641243 641329 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG{S) SACRIFICED BY DESIGN TEST DAY 114 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 114 ALOPECIA LEFT FRONT LEG{S ) MASS 1 3.5 cm RIGHT SIDE(S) MASS 2 2.0 cm LEFT SIDE(S) SACRIFICED BY DESIGN TEST DAY 117 FIRST DAY LAST DAY OBSERVED OBSERVED 0 21 0 21 0 21 0 21 14 14 14 14 1034 Company Sanitized. Does nol contain tsca net H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX W REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Pj FEMALE RATS 1035 Company Sanitized. Does not contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Pi FEMALE RATS EXPLANATORY NOTES Footnotes: a No evidence o f copulation was found, but animal was pregnant. Data were excluded from statistical analysis since the animal was pregnant during part of the estrous cycle evaluation. b No precoital interval could be calculated since no evidence of copulation was found. c Mean cycle length was not calculable due to insufficient data. Abbreviations: -- = No Data 1036 Company Sanitized. Does not contain TSCA Ctl? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 641389 641358 641332 641371 641324 641310 641328 641337 641236 641345 641289 641308 641346 641349a 641306 641261 641388 641403 641255 641317s 22 22 25 22 23 21 23 23 26 23 25 26 23 35 22 25 26 24 26 35 5% 23% 24% 23% 22% 24% 13% 4% 23% 22% 8% 31% 13% 14% 18% 24% 12% 25% 31% 9% 82% 64% 64% 77% 65% 71% 74% 74% 58% 61% 76% 65% 74% 80% 59% 72% 88% 50% 62% 74% 14% 14% 12% 0% 13% 5% 13% 22% 19% 17% 16% 4% 13% 6% 23% 4% 0% 25% 8% 17% 4.50 4.00 4.00 4.00 5.00 4.00 5.33 4.67 4.75 4.50 6.67 4.20 4.00 4.50 5.00 4.00 10.50 4.00 4.75 4.00 1 1 4 1 2 1 2 3 5 2 4 5 2 __ jb i 4 5 3 5 __ jb 1037 Company Sanitized. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP IV-0 : 50 MG/KG/DAY ANIMAL NUMBER 641350 641276 641258 641272 641351 641274 641304 641297 641263 641378 641323 641348 641365 641373 641318 641338 641231 641286 641315 641376 NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS 25 12% 24 25% 34 9% 22 18% 22 18% 29 24% 22 32% 23 26% 23 13% 21 10% 22 23% 22 18% 23 22% 26 23% 25 40% 23 22% 25 28% 26 19% 28 32% 25 28% PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 76% 67% 76% 68% 68% 69% 50% 74% 87% 71% 77% 68% 61% 65% 48% 61% 52% 65% 64% 64% 12% 8% 15% 14% 14% 7% 18% 0% 0% 19% 0% 14% 17% 12% 12% 17-% 20% 15% 4% 8% 5.00 4.75 5.40 5.00 4.00 6.67 4.00 4.00 __ c __ c 4.00 5.00 4.00 4.75 5.25 5.00 4.20 5.00 4.20 5.67 5 4 13 2 2 8 1 2 2 1 1 1 2 5 4 2 4 5 7 5 1038 Company Sanitized Does not contain TSCA CBI H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VI-0: 250 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 641360 641392 641235 641238 641233 641277 641386 641252 641280 641271 641316 641339 641303 641367 641347 641334 641228 641239 641333 641381 24 23 23 22 22 22 22 22 22 22 22 23 24 27 25 31 25 24 33 23 21% 26% 22% 32% 23% 18% 27% 23% 27% 14% 23% 26% 21% 19% 28% 35% 4% 13% 15% 26% 54% 61% 52% 50% 68% 73% 68% 64% 55% 68% 68% 70% 54% 70% 48% 61% 68% 75% . 79% 61% 25% 13% 26% 18% 9% 9% 5% 14% 18% 18% 9% 4% 25% 11% 24% 3% 28% 13% 6% 13% 4.00 4.00 4.00 4.50 4.00 4.67 4.00 4.00 4.00 5.00 4.00 4.00 4.00 4.60 4.00 5.00 7.00 6.33 4.00 5.67 4 2 2 1 1 1 1 1 1 1 1 2 3 6 4 10 4 3 __ b 2 1039 Company Sanitized. Does not contain TSC CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VIII-0: 1000 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRTJS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE PRECOITAL LENGTH INTERVAL (days) (days)__ 641343 641368 641307 641401 641353 641320 641246 641402 641393 641265 641329 641243 641370 641248 641296 641273 641230 641284 641242 641254 24 13% 75% 13% 5.00 3 23 26% 70% 4% 4.25 2 22 23% 77% 0% 4.25 1 22 27% 64% 9% 4.00 1 22 23% 55% 23% 4.00 1 26 12% 77% 12% 5.67 5 22 27% 50% 23% 3.67 2 22 23% 73% 5% __ c 3 23 22% 74% 4% 4.00 2 25 24% 64% 12% 4.00 4 25 24% 72% 4% 4.00 4 22 41% 45% 14% 5.67 1 26 15% 77% 8% 5.00 5 26 27% 54% 19% 5.00 5 21 5% 76% 19% 5.00 1 22 36% 55% 9% 5.33 1 24 29% 50% 21% 4.75 4 22 36% 64% 0% 4.67 1 27 33% 67% 0% 4.60 6 23 22% 52% 26% 4.00 2 1040 Company Similized. Does not contain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX X REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS 1041 Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS EXPLANATORY NOTES Notes: Refer to footnotes located in Individual Animal Estrous Cycle Parameters During Premating and Cohabitation appendix for individual animal variation. Test Days 50-70 = Premating Test Days 71-85 = Cohabitation period Abbreviations: D = Diestrus E = Estrus P = Proestrus X = No sample or stage could not be defined from sample. 1042 gonipany Sanitized. Does not contain tsca CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY ANIMAL NUMBER 641389 641358 641332. 641371 641324 641310 641328 641337. 641236 _6_41_3_45_ 49 641308 _6_41_3_46_ 641306 _6_41_2_61_ 641403 641255 641317 E D 11 DPE D L_ D P E;D D _D__1D DD 58 D D D TEST DAYS 60 61 62 63 64 65 66 67j68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 D D D DD DDD D D P E T_ T_ D E El D m ~d ~"b " P rs- E "d ""d " D E E "d ""d ~ D " E ~D~ D D E D T5" D D p D D P E B B "d " D "d - D P E B B B B B 1"d " D D E D D d;P 1P E d D E :B P ,B T T T T B E B fi "d " " __ Ttw l D E :b D; P BP E 'D "5" "b "~D~ D ~D~ "d """" D E~ DP "5" "b ""b ~ D D D1 E "d " D E ;d T T - w DDD D D D D T T ~s: D B B I e ~D~ "fi" bD DD 1 D "d " p E Bp T5 ID D" D E ~D~ D I D 1 E iB B ~ flg| LL 1DD D 1 P 1 E l p ~5~H ~D~ "d" "fi" td ~"d ~ p 9 ^ U |SI8 S *>w4s!ui0 HOU IS> 1043 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP IV-0 : 50 MG/KG/DAY DuPont-4739 .Qompany Sanitized. Does not contain 7SCA CBI 1044 H-24616: Subchronic Toxicity 90-D ay Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VI-0: 250 MG/KG/DAY 71 72 D "5" g E P 74 75 76 11 78 79 80 81 82 83 641239 641333 641381 DD DXX DDD z H-- 1 P ~ P p5T "EH DQ ~D~ r u T n H ~ D. d m m DE -- D~ E D ;D ;T>' ~ D 1 z HZ j _ "d" "d " "d ""ET 'D D "d *"ET "5" __ _____1 ____ .Bspaey Sanitized. Does not contain TSC CO" 1045 H-24616: Subchronic Toxicity 90-D ay Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VIII-0: 1000 MG/KG/DAY 1046 iww Ujeiuoa PM s@0 "P021SWS Iw d n egi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX Y REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS 1047 Gpnpm^f BmMked, Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS EXPLANATORY NOTES Footnotes: a No sperm. Data excluded from calculations. 1048 (SwFtpMtf Sanitized, Dees not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS GROUP I--0 0 MG/KG/DAY Animal Percent Number Motile 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 90 97 93 95 96 86 91 92 94 95 GROUP V-0 250 MG/KG/DAY Animal Number Percent Motile 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 92 91 90 93 92 95 91 95 94 91 GROUP III-O 50 MG/KG/DAY Animal Number Percent Motile 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 96 89 87 94 96 90 95 95 92 95 GROUP VII-0 1000 MG/KG/DAY Animal Number Percent Motile 641110 641096 641212 641068 ' 641093a 641054 641208 641193 641207 641139 95 91 93 92 -- 75 97 92 85 91 1049 mpanySanitized. Does nocontain TSCA C8I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX Z REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS 1050 Company Sanitized. Does not contain TSCA < H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS Footnotes: EXPLANATORY NOTES a No sperm. Data excluded from calculations. 1051 m p m i Saniiked. Does not contain H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS j GROUP 1-0 : 0 MG/KG/DAY Animal Number 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 Total Normal 199 196 200 194 198 198 196 196 199 195 Tail Abnormal 0 2 0 3 0 1 2 1 1 1 Head Abnormal 1 2 0 3 2 1 2 3 0 4 Tail & Head Percent Abnormal Normal 0 99.5 0 98.0 0 100.0 0 97.0 0 99.0 0 99.0 0 98.0 0 98.0 0 99.5 0 97.5 GROUP III-O: 50 MG/KG/DAY Animal Number Total Normal 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 195 199 193 194 199 194 195 196 198 198 Tail Abnormal 1 0 0 4 1 0 1 1 2 1 Head Abnormal 4 1 7 2 0 6 4 3 0 1 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 97 .,5 99..5 96..5 97,.0 99..5 97 .0 97 .5 98 .0 99 .0 99 .0 1052 Cempanf Sanitized Does not eonfain t?ca csi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS GROUP V-0: 250 MG/KG/DAY Animal Number 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 Total Normal 199 199 196 199 197 195 190 194 194 195 Tail Abnormal 1 1 4 0 2 2 2 3 2 3 Head Abnormal 0 0 0 1 1 3 8 3 4 2 Tail & Head Percent Abnormal Normal 0 99.5 0 99.5 0 98.0 0 99.5 0 98.5 0 97.5 0 95.0 0 97.0 0 97.0 0 97.5 GROUP VII-0: 1000 MG/KG/DAY Animal Number 641110 641096 641212 641068 641093a 641054 641208 641193 641207 641139 Total Normal 196 196 198 198 -- 195 190 198 195 192 Tail Abnormal 1 1 0 1 1 3 1 3 2 Head Abnormal 4 3 2 1 4 7 1 2 6 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 Percent Normal 98.0 98.0 99.0 99.0 97.5 95.0 99.0 97.5 96.0 1053 Company Sanitized. Does not contain TSCA cbi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX AA REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN Pi MALE RATS 1054 Company Sanitized. Does not contain T$CA C8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Pi MALE RATS GROUP 1-0 : 0 MG/KG/DAY Animal Number Epididymal Sperm______ Testicular Spermatids Per cauda Per g cauda Per testis Per g ______________ testis 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 298.1 266.6 302.8 347.2 355.4 301.6 298.1 319.2 322.7 327.3 1226.2 822.1 1252.7 1298.4 1271.5 1040.0 1163.1 812.3 1195.4 1016.2 140.9 119.3 123.4 109.3 147.3 190.6 178.3 190.6 157.8 144.4 93.8 77.2 85.9 77.5 89.5 103.9 107.6 102.9 101.2 98.5 GROUP III-0: 50 MG/KG/DAY Animal ___ Epididymal Sperm______ Testicular Spermatids Number Per cauda Per g Per testis Per g cauda _____________ testis 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 288.8 370.6 306.3 308.6 334.4 313.3 370.6 336.7 281.7 333.2 1263.7 1468.8 1198.3 1113.7 1263.1 1164.2 1136.0 1190.9 1079.0 950.0 118.1 137.4 140.3 146.1 151.4 151.4 170.1 157.3 177.7 175.4 79.8 105.5 96.4 80.8 101.7 105.2 112.2 102.9 105.7 102.2 1055 Company Sanitized. Does not contain TSC CS! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Pi MALE RATS GROUP V-0: 250 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 370.6 316.8 286.4 286.4 320.3 242.0 353.1 322.7 376.4 339.0 1281.4 1265.2 1375.0 1218.8 1244.9 1080.8 1029.6 1046.2 1063.6 1144.2 Testicular Spermatids Per testis Per g testis 169.5 142.1 138.0 119.3 125.7 100.0 180.0 208.7 172.4 203.4 114.4 101.9 101.6 90.1 82.2 56.9 102.9 128.4 101.3 113.2 GROUP VII-0 : Animal Number 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 MG/KG/DAY Epididymal Sperm Per cauda Per g cauda 367.1 300.5 312.1 264.2 272.4 301.6 343.7 316.8 351.9 382.3 1275.9 897.6 1352.4- ' 1094.9 986.2 990.8 1258.9 1191.9 1052.9 1247.2 Testicular Spermatids Per testis Per g testis 173.6 162.5 139.1 128.6 107.6 155.5 174.2 129.2 190.6 143.8 99.4 100.2 99.1 82.7 91.2 100.8 124.0 96.6 106.2 102.8 1056 Company Sanitized. Does not contain TSCA ( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX BB REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION 1057 osmjWnfI m I W . Does ms?eonfefret s c a C H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION EXPLANATORY NOTES Note Column labeled "Plug Observed" + indicates that a copulatory plug was observed - indicates that no copulatory plug was observed Column labeled "Litter Produced" + indicates that a litter was produced - indicates that no litter was produced Footnote a Because a copulatory plug was not observed, the start of gestation is unknown and, therefore, gestation length cannot be determined. Abbreviations -- = No Data 1058 Company Sanitized. Doem *con!a,n TSC H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 FEMALE ANIMAL# 641345 641236 641337 641328 641310 641324 641371 641332 641358 641389 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: 11-0,1-0 DOSE: 0 MG/KG/DAY MALE #1 ANIMAL# 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 641174 641107 641072 641053 641168 PLUG OBSERVED + + + + + + + + + + + + + + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER GESTATION PRODUCED LENGTH(days) 21 22 22 22 22 23 22 22 + _a + 22 + 22 + 21 + 22 + 22 + _a + 22 + 22 + 21 1059 Compmsf Bmfflze Does m <oonMn TSCA CS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: IV-0,III-O DOSE: 50 MG/KG/DAY FEMALE ANIMAL# 641378 641263 641297 641304 641274 641351 641272 641258 641276 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 MALE #1 ANIMAL# 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 641103 641181 641171 641111 641062 641156 641173 641121 641074 641191 PLUG OBSERVED ,+ + + + + + + + * + -f + + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + * + + + + + + + + + + + + + GESTATION LENGTH(days) 22 21 22 23 21 22 22 22 22 22 22 22 22 22 22 22 22 21 1060 Company Sanitized, Does not contain TSC C5 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 FEMALE ANIMAL# 641271 641280 641252 641386 641277 641233 641238 641235 641392 641360 641381 641333 641239 641228 641334 641347 641367 641303 641339 641316 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VI-0,V-0 DOSE: 250 MG/KG/DAY MALE #1 ANIMAL# 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 641124 641082 641151 641195 641122 641184 641142 641120 641179 641164 PLUG OBSERVED + + + + + + + + + + + - + + + + + + + MALE #2 ANIMAL# PLUG LITTER OBSERVED PRODUCED + - - _ + + + + + + - _ + _ + + + + GESTATION LENGTH(days) 22 -- -- -- 21 22 22 21 22 22 -- -- 22 -- 23 23 22 22 22 1061 Company Sanitised. Dees not contain TSCACBl ') 2) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 FEMALE ANIMAL# 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242 641284 641230 641273 641296 641248 641370 641243 641329 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VIII-0,VII-0 DOSE: 1000 MG/KG/DAY MALE #1 ANIMAL# 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 641152 641182 641150 641211 641145 PLUG OBSERVED + + + + + + + + + -f + 4* + f + + + + + + MALE #2 ANIMAL# PLUG LITTER OBSERVED PRODUCED + + + + + + + + + + _ + + + + + + + GESTATION LENGTH{days) 22 22 22 22 22 22 21 22 22 22 22 -22 22 22 22 22 22 22 1062 Company Sanitized. Does not contain TSCA CBf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX CC REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY 1063 Company Sanitized. Does not contain TSCCB) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY EXPLANATORY NOTES Footnotes a Number o f pups bom exceeded the number o f implantation sites counted. b No litter was delivered. c No implantation site data recorded; Animal No. 641392 died on lactation day 13. Abbreviations - = No data 1064 Company Sanitized. Does not contain TSCA C8I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: II-O DOSE: 0 MG/KG/DAY Animal Number 641345 641236 641337 641328 641310 641324 641371 641332 641358^* 641389b* 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Number of Implantation Sites ' 13 17 9 16 17 17 17 16 0 0 6 12 17 16 11 15 19 19 15 17 Implantation Efficiency 100.00 100.00 88.89 68.75 94.12 70.59 ___a 93.75 -- -- 100.00 ___a 100.00 93.75 100.00 100.00 94.74 78.95 93.33 82.35 1065 Company Sanitized. Does not contain TSCA Cl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: IV-0 DOSE: 50 MG/KG/DAY Animal Number 641378 641263 641297 641304 641274-k 641351 641272 641258 641276b 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Number Implantatic 18 13 15 12 0 15 14 16 0 16 9 18 13 16 16 16 17 14 15 15 Implantation Efficiency 94.44 100.00 86.67 50.00 100.00 92.86 100.00 100.00 77.78 100.00 ___a 93.75 81.25 93.75 94.12 92.86 100.00 93.33 w 1066 Company Sanitized. Does not contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VI-0 DOSE: 250 MG/KG/DY Animal Number 641271 641280* 641252* 641386* 641277 641233 641238 641235 641392e 641360 641381* 641333* 641239 641228* 641334 641347 641367* 641303 641339 641316 Number Implantatio 15 0 0 0 13 16 17 12 -- 15 0 0 18 0 18 17 0 15 17 15 Implantation Efficiency 100.00 100.00 93.75 76.47 83.33 86.67 88.89 88.89 64.71 93.33 82.35 86.67 1067 Company Sanitized. Does not contain TSCA CSf 3 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VIII-0 DOSE: 1000 MG/KG/DAY Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242k 641284 641230 641273^ 641296 641248 641370 641243 641329 Number of Implantation Sites 16 16 15 13 17 16 15 15 17 15 20 0 18 14 0 17 13 11 15 15 Impiantati Efficienc 75.00 93.75 93.33 92.31 88.24 100.00 100.00 86.67 100.00 ___3 95.00 -- 88.89 100.00 -- 88.24 ___3 100.00 100.00 100.00 1068 Company Sanitized. Does net contain TSC H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX DD REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL PUP SURVIVAL: Fi GENERATION 1069 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL PUP SURVIVAL: Fj GENERATION EXPLANATORY NOTES DuPont-4739 Footnotes a No litter delivered. b Dam was found dead on lactation day 13 (test day 107). All pups were dead before day 7 of lactation. 1070 Company Sanitized. Does not contain TSCA Cl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358s 641389s 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 BORN 13 17 8 11 16 12 18 15 -- -- 6 16 17 15 11 15 18 15 14 14 NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 13 13 8 8 17 16 8 8 8888 11 10 8 8 14 14 8 8 12 12 8 8 18 18 8 8 15 15 8 8 ---- -- -- -- _____ -- -- 6666 16 16 8 8 17 17 8 8 15 14 8 8 11 11 8 8 13 13 8 8 17 17 8 8 15 15 8 8 14 14 8 8 14 13 8 8 14 DAY 21 88 88 88 88 88 88 88 88 ---- ____ -- 6 8 8 8 8 8 8 8 8 8 VD.COcocococococococo 1071 Company Sanitized. Does net contain TSCft c at H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358a 641389a 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 BORN 6 6 5 5 9 4 8 10 -- 3 5 9 8 3 9 8 7 8 6 NUMBER OF MALE PUPS BORN ,PRECULLING POSTCULLING ALIVE* DAY 4 DAY 4 DAY 7 6 64 4 6644 5555 5544 9944 4444 8 84 4 10 10 4 4 3333 5544 9944 8833 333 3 8844 8844 7744 8844 6544 DAY 14 DAY 21 44 44 55 44 44 44 44 44 3 4 4 3 3 4 4 4 4 4 1072 Compasiir Sanitized. Does not contain TSCCB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358a 641389a 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 BORN 7 11 3 6 7 8 10 5 -- -- 3 11 8 7 8 6 10 8 6 8 NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 77 11 10 33 65 55 88 10 10 55 44 44 33 44 44 44 44 44 -- -- 33 11 11 88 76 88 55 99 88 66 88 33 44 44 55 55 44 44 44 44 44 DAY 14 DAY 21 44 44 33 44 44 44 44 44 33 44 44 55 55 44 44 44 44 44 1073 Company Sanitized Does not contain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358s 641389s 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 NUMBER OF PUPS SEX RATIO (MALES) BORN ALIVE 0-4 DAY VIABILITY 0.46 0.35 0.63 0.45 0.56 0.33 0.44 0.67 _--_ 0.50 0.31 0.53 0.53 0.27 0.60 0.44 0.47 0.57 0.43 100.0 100.0 100.0 100.0 87.5 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 86.7 94.4 100.0 100.0 100.0 100.0 94.1 100.0 90.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 100.0 100.0 100.0 100.0 100.0 92.9 DuPont-4739 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1074 Company Sanitized, Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358a 641389s 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 . -- -- 100.0 100.0 100.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 83.3 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1075 Company Sanitized. Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358 641389 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 NUMBER OF FEMALE PUPS BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 71.4 100.0 100.0 100.0 100 0 90 9 100 0 83 3 100 0 100 0 100 0 100 0 1UU.U 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 83.3 90.0 100.0 100.0 100.0 100 0 100 0 100 0 85 7 100 0 100 0 100 0 100 0 100 0 100 .0 IUU .u 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1076 Company Sanitized. Does not contain TSC CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER 641378 641263 641297 641304 641274s 641351 641272 641258 641276s 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 BORN 17 13 13 6 -- 15 13 16 -- 16 7 18 14 15 13 15 16 13 15 14 NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 4 DAY 7 17 17 13 13 13 12 66 ---- 14 14 13 13 16 16 ---- 16 15 77 18 18 14 14 15 14 13 13 15 15 16 14 13 13 15 15 14 14 88 88 88 66 ____ -- 88 88 88 ____ -- 88 77 88 88 88 88 88 88 88 88 88 DAY 14 DAY 21 88 88 88 66 ---- 88 88 88 ---- 88 77 88 88 88 88 88 88 88 88 88 1077 Company Sanitized. Doss not contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER 641378 641263 641297 641304 641274 641351 641272 641258 641276 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 BORN 9 3 7 1 -- 6 5 6 -- . 8 4 9 8 5 4 7 9 10 8 6 NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 9944 3333 7644 1111 ---- -- -- 6644 5544 6644 ---- -- -- 8844 4444 9944 8844 54 4 4 4444 7744 9844 10 10 5 5 8844 6644 DAY 14 DAY 21 4 3 4 1 44 44 44 44 44 44 44 44 44 44 44 55 44 44 CO pH 1078 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER 641378 641263 641297 641304 641274a 641351 641272 641258 6412763 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 BORN 8 10 6 5 -- 9 8 10 -- . 8 3 9 6 10 9 8 7 3 7 8 NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 8844 10 10 5 5 6644 5555 -- _____ -- -- 8844 8844 10 10 4 4 -- _____ -- -- 8744 3333 9944 6644 10 10 4 4 9944 8844 7644 3333 7744 8844 DAY 14 DAY 21 4 5 4 5 4 4 4 44 33 44 44 44 44 44 44 33 44 44 ^ m ^ tn i^ ^ 1079 Company Sanitized. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER 641378 641263 641297 641304 641274a 641351 641272 641258 641276a 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY 0.53 0.23 0.54 0.17 -- 0.40 0.38 0.38 -- 0.50 0.57 0.50 0.57 0.33 0.31 0.47 0.56 0.77 0.53 0.43 100.0 100.0 100.0 100.0 -- 93.3 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.3 100.0 -- 100.0 100.0 100.0 -- 93.8 100.0 100.0 100.0 93.3 100.0 100.0 87.5 100.0 100.0 100.0 DuPont-4739 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1080 Company Sanitized. Does not contain TSC C3 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER 641378 641263 641297 641304 641274a 641351 641272 641258 641276a 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 85.7 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 100.0 80.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1081 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL NUMBER 641378 641263 641297 641304 641274s 641351 641272 641258 641276s 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 NUMBER OF FEMALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 -- 88.9 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 85.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1082 Company Sanitized. Does not contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER 641271 641280a 641252s 641386s 641277 641233 641238 641235 641392* 641360 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 BORN 15 -- -- -- 13 15 13 10 13 13 -- -- 16 -- 16 11 -- 14 14 13 NUMBER OF PUPS BORN PRECULLING POSTCLLING ALIVE DAY 4 DAY 4 DAY 7 14 13 8 8 ---- -- -- -------- ---- 13 13 8 8 15 15 8 8 12 12 8 8 10 10 8 8 13 12 8 0 13 13 8 8 -------- -- -- __ -- 16 16 8 8 -- -- __ -- 16 16 8 8 11 11 8 8 -- -- __ -- 14 13 8 8 14 14 8 8 13 13 8 8 DAY 14 DAY 21 88 ---- -- __ 88 88 77 88 ---- 88 ---- ---- 88 ---- 88 88 ---- 88 88 88 1083 .osnpOTf Sanitized. Does not contain t w a crK MM I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 ANIMAL NUMBER 641271 641280a 641252a 641386a 641277 641233 641238 641235 6413920 641360 641381a 641333a 641239 641228a 641334 641347 641367a 641303 641339 641316 BORN 6 -- -- -- 8 9 5 4 8 4 -- -- 12 -- 11 7 -- 8 6 6 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 6544 ------ -- ------ -- ---- -- -- 884 4 99 4 4 55 4 4 44 4 4 88 4 0 444 4 ------ -- ------ -- 12 12 4 4 ------ -- 11 11 4 4 77 44 ---- -- -- 8844 6644 66 4 4 DAY 14 DAY 21 44 44 44 44 44 44 44 4 4 4 4 4 1084 B p o if SanRhedL 5 ! m n M n r s m H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER 641271 641280a 641252a 641386a 641277 641233 641238 641235 641392-k 641360 641381a 641333a 641239 641228a 641334 641347 641367a 641303 641339 641316 BORN 9 -- -- -- 5 6 8 6 5 9 -- -- 4 5 4 -6 8 7 NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 884 4 DAY 14 DAY 21 44 55 4 4 4 66 4 4 4 rfLO 77 4 4 3 664 4 4 5 9 4 9 4 4 0 4 4 4 44 4 4 4 4 554 444 44 44 4 4 6 5 4 44 4 8 84 44 4 7 7 4 444 1085 ft'wyaw HanMkecL Bros rot contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392-k 641360 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY 0.40 93.3 92.9 0.62 0.60 0.38 0.40 0.62 0.31 0.75 0.69 0.64 0.57 0.43 0.46 100.0 100.0 92.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.3 100.0 100.0 100.0 100.0 92.9 100.0 100.0 DuPont-4739 LACTATION INDEX 100.0 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0 1086 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392* 641360 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 -- -- -- 100.0 100.0 100.0 100.0 100.0 100.0 -- -- 100.0 -- 100.0 100.0 -- 100.0 100.0 100.0 83.3 -- -- ----- 100.0 100.0 100.0 100.0 100.0 100.0 -- -- 100.0 -- 100.0 100.0 -- 100.0 100.0 100.0 . 100.0 ----- -- -- 100.0 100.0 100.0 100.0 -- 100.0 -- --~" 100.0 -- 100.0 100.0 -- 100.0 100.0 100.0 DuPont-4739 1087 CwsupOTf' Sanitized. Does not contain TSCA GBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392* 641360 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 NUMBER OF FEMALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 88.9 -- -- -- 100.0 100.0 87.5 100.0 100.0 100.0 -- -- 100.0 -- 100.0 100.0 -- 100.0 100.0 100.0 100.0 -- -- -- 100.0 100.0 100.0 100.0 80.0 100.0 -- -- 100.0 -- 100.0 100.0 -- 83.3 100.0 100.0 100.0 -- -- -- 100.0 100.0 75.0 100.0 100.0 -- -- 100.0 -- 100.0 100.0 -- 100.0 100.0 100.0 DuPont-4739 1088 Sanitized Does not contain TSCA CBi H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 BORN 12 15 14 12 15 16 15 13 17 18 19 -- 16 14 -- 15 15 11 15 15 NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 12 12 8 8 14 14 8 8 14 14 6 6 12 12 8 8 15 15 8 8 15 15 8 8 15 14 8 8 13 13 8 8 17 17 8 8 18 18 8 8 19 19 8 8 ---- 16 16 8 8 14 14 8 8 -- -- _____ -- 13 13 8 8 15 15 8 8 11 11 8 8 15 14 8 8 15 15 8 8 DAY 14 DAY 21 88 88 66 88 88 88 88 88 88 88 88 88 88 ---- 88 88 88 88 88 1089 Company Sanitized. Does not contain TSCA CO! 1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242a 641284 641230 641273s 641296 641248 641370 641243 641329 BORN 10 8 2 5 9 9 6 10 9 9 7 -- 6 4 -- 9 5 4 6 10 NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 10 10 6 6 7744 2 22 2 5 54 4 994 4 884 4 6 54 4 10 10 5 5 9944 9 94 4 7744 -- 6 64 4 4444 -- 7744 554 4 444 4 6644 10 10 4 4 DAY 14 DAY 21 66 44 22 44 44 44 44 55 44 44 44 44 44 44 44 44 44 44 1090 Sanitized. Doe? tv.r! o T H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242a 641284 641230 641273a 641296 641248 641370 641243 641329 BORN 2 7 12 7 6 7 9 3 8 9 12 -- 10 10 6 10 7 9 5 NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 222 2 7744 12 12 4 4 7744 664 4 7744 9944 3333 8844 994 4 12 12 4 4 _____ -- -- 10 10 4 4 10 10 4 4 6 64 4 10 10 4 4 7744 9 84 4 5544 DAY 14 DAY 21 22 44 44 44 44 44 44 33 44 44 44 -- 4 4 4 4 4 4 4 tf.ffs.tfs. tfi I its*rfs 1091 $Zompm% Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP': VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242a 641284 641230 641273s 641296 641248 641370 641243 641329 NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY 0.83 0.53 0.14 0.42 0.60 0.56 0.40 0.77 0.53 0.50 0.37 -- 0.38 0.29 -- 0.60 0.33 0.36 0.40 0.67 100.0 93.3 100.0 100.0 100.0 93.8 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 -- 86.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 100.0 100.0 100.0 100.0 -- 100.0 100.0 -- 100.0 100.0 100.0 93.3 100.0 DuPont-4739 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1092 O w sp f Sanitized. Does not contain TSCA CO! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 87.5 100.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 -- 77.8 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 83.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1093 ComPany Sanitized. Does not conta'n TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 NUMBER OF FEMALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-4739 1094 Company Sanitized. Doss not contain TSCA Q3I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation ReproductionJEvaluations DuPont-4739 APPENDIX EE REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL PUP WEIGHTS: Fi GENERATION 1095 Company Sanitized. Does not contain "^SCAf*BI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL PUP WEIGHTS: F, GENERATION EXPLANATORY NOTES DuPont-4739 Footnotes a No litter delivered. b No live pups on lactation day 7. Found dead test day 107. . One pup was incorrectly designated as female. Data were excluded from calculations. U 03 1096 Company Sanitized. Does no? contain Cft! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 0 Animal Number Pup Sex 641345 S 641236 641337 641328 641310 641324 641371 641332 641358a 641389a 9 3 9 3 9 S 9 3 9 < 9 3 9 3 9 3 9 3 9 Group: II-O 234 677 7~4 772 777 6.1 6.4 6.9 6.2 6.8 6.8 7.0 6.1 6.1 5.9 6.0 6.3 8.0 7.3 8.1 7.8 7.6 7.2 6.9 7.6 9.0 7.7 7.5 7.1 7.6 7.7 7.9 6.7 7.1 6.8 7.3 5.8 6.5 6.3 6.8 7.3 6.8 7.2 7.6 6.4 7.1 7.5 5.7 7.3 6.2 7.4 6.9 6.4 6.2 6.2 5.2 6.8 6.9 7.6 7.2 7.1 6.8 6.9 6.9 Dose: 0 mg/kg/day Pup Humber 567 771 6.4 6.8 6.1 6.8 T7 7.2 6.2 6.3 6.8 5.9 89 ~~ 6.1 6.2 8.2 6.8 8.2 6.5 6.7 5.9 7.0 6.5 6.8 7.2 6.6 7.2 7.0 6.5 6.4 6.9 6.4 5.7 6.6 5.5 6.2 6.3 6.8 7.6 7.4 6.6 6.9 6.8 DuPont-4739 10 11 6.8 5.4 6.2 7.2 1097 .ompOTf SmMm. Does not contain t** /eft H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 0 Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Group: II-0 Pup Sex 1 3 7.1 2 8.0 3 6.8 2 6.0 3 7.1 2 6.3 6.6 2 6.7 6 7.8 2 5.6 3 6.7 2 6.1 6 6.7 2 5.0 3 6.2 2 5.5 3 7.5 2 6.2 3 3.5 2 5.7 2, 7.9 7.2 6.6 5.4 7.0 6.6 7.2 7.1 7.0 6.9 6.8 6.1 4.4 5.8 5.7 6.0 7.1 6.6 5.9 5.2 3 7.6 7.0 7.0 6.0 6.7 6.9 7.5 6.5 7.5 6.8 6.7 6.1 4.8 5.4 6.3 5.6 6.9 7.5 6.0 5.4 4 6.5 6.4 6.6 6.4 7.8 6.8 7.7 6.6 6.7 5.5 5.3 6.4 6.1 5.4 6.6 5.6 5.0 Dose: 0 mg/kg/day Pup Number 567 8 6.2 6.3 6.5 6.6 7.3 6.6 6.8 6.7 6.0 5.5 5.8 6.9 5.8 6.1 6.3 5.9 5.3 5.9 6.5 5.9 7.2 6.6 6.7 6.8 5.7 5.0 6.7 6.5 4.0 6.3 5.8 5.2 6.4 6.5 6.4 7.2 6.6 6.5 7.2 5.2 4.2 6.1 5.9 6.6 5.6 6.2 7.5 6.0 7.4 6.3 6.3 5.8 6.0 6.4 7.5 5.8 9 5.7 6.3 5.2 DuPont-4739 10 11 6.0 6.1 1098 fiompony SanHIzed. Does no! contain tsca CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 0 Animal Number 641378 641263 641297 641304 641274s 641351 641272 641258 641276s 641350 Pup Sex a 2 a 2 a 2 a 2 a 2 a 2 a 2 a 2 <j 2 d 2 Group: IV-0 l23 6.8 7.0 674 6.3 6.3 6.3 6.0 5.6 6.0 5.2 5.6 5.6 7.5 7.6 7.9 7.2 6.9 6.8 7.9 7.3 8.0 7.6 Dose: 50 mg/kg/day Pup Number 4 5 67 8 6.4 "671 772 6.5 677 6.5 7.4 5.9 6.5 6.2 5.6 5.4 5.7 5.5 5.6 7.8 8.1 7.8 7.1 7.2 7.3 7.2 7.5 6.1 6.0 5.7 6.1 6.1 5.7 5.9 6.0 5 . 8 5 . 6 5 . 5 6.1 5.4 5.5 5.7 7.3 7.3 7.1 6.6 6.7 7.1 6.5 6.2 7.2 6.8 6.5 6.2 6.3 7.1 7.5 7.1 7.3 6.9 7.6 7.2 7.2 6.9 7.2 6.7 6.5 6.5 5.2 6.8 7.0 6.1 6.6 6.8 6.5 6.4 6.4 6.7 7.1 6.7 7.3 6.3 6.5 5.7 6.7 DuPont-4739 9 10 679 5.8 5.8 6.5 6.9 1099 ew iw f Sanfied Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: IV-0 Dose: 50 mg/kg/day Animal Number 641376' 641315 641286 641231 641338 641318 641373 641365 641348 641323 Pup Sex 1 S 7.1 9 6.6 6.3 9 7.6 9 6.7 S 6.4 9 6.1 6.5 9 6.2 6.3 9 5.8 S 7.2 9 6.8 S 7.6 9 7.5 7.1 9 6.3 6.1 9 5.9 U1 00 2 7.3 5.8 6.7 6.1 6.1 6.1 7.3 6.9 6.8 6.4 6.7 6.0 6.9 6.5 7.6 7.6 6.9 6.5 6.0 6.1 Pup Number 3456 6.7 6.7 5.8 7.0 6.8 6.8 6.4 6.4 5.9 6.3 6.4 6.9 6.9 6.7 7.4 6.4 6.6 6.3 6.4 6.7 6.9 7.3 6.4 6.1 5.9 6.9 6.5 7.0 6.0 5.7 6.2 6.8 6.0 6.0 6.1 6.5 6.3 5.9 5.5 6.0 7.0 7.1 6.7 7.3 6.5 6.8 6.6 6.7 8.0 7.3 7.7 8.0 7.0 6.4 6.3 6.6 6.7 6.5 6.5 6.3 6.6 6.7 6.1 6.3 6.7 6.3 6.2 5.8 6.0 78 6.7 5.4 7.1 6.5 6.3 6.1 6.6 5.9 6.7 6.7 7.6 7.1 6.1 5.7 5.4 6.1 6.2 6.2 5.7 6.7 7.4 6.8 5.7 DuPont-4739 9 10 5.7 6.2 6.2 5.0 6.1 7.0 7.8 8.1 1100 Sanitized. Bees not contain TSCA CBf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Individual Pup Weights (grams): Fi Gnration Lactation Day 0 Animal Number 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392-b' c 641360 Group: VI-0 Pup Sex l 2 3 6.9 6.6 2 6.6 6.0 3 2 3 2 3 2 3 6.7 6.0 2 5.8 6.0 3 5.7 6.3 2 5.9 5.8 3 7.5 6.9 2 7.1 6.2 3 6.2 6.2 2 5.5 5.8 3 6.7 6.7 2 6.4 5.9 3 7.4 6.9 2 7.3 7.2 3 6.4 6.6 5.9 6.2 6.7 5.8 7.3 5.4 5.5 5.9 6.4 6.2 7.5 6.9 Dose: 250 mg/kg/day Pup Number 456 6.0 6.4 6.6 6.2 5.9 5.8 7 6.8 6.6 6.0 6.4 6.0 6.1 6.0 6.1 6.5 6.2 6.5 5.8 5.9 5.7 7.1 7.1 6.2 6.2 6.9 6.6 6.1 5.8 5.8 5.5 6.4 6.5 5.7 6.0 5.4 6.4 6.3 6.5 6.6 7.3 6.7 8 5.8 6.6 6.2 5.8 7.5 9 3 !| 1101 'C&mpmy Sanitized. Does no eantan r^ A CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Individual Pup Weights (grams): Fi Generation ' Lactation Day 0 Group : VI-0 Dose:; 250 mg/kg/day Pup Number Animal Number Pup Sex 1 2 3 4 5 6 7 8 9 10 11 12 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 6 9 s 9 5.8 5.8 6.1 6.9 5.9 6.6 6.7 6.2 5.8 6.0 5.4 5.8 9 6.2 5.8 4.9 5.8 9 6.2 7.2 6.7 7.3 6.9 6.5 7.3 6.4 7.4 6.3 6.6 9 5.6 7.2 6.1 6.4 5.4 8.3 8.6 7.7 8.4 8.7 7.3 8.1 9 8.2 7.8 8.6 7.5 5 9 6 7.7 6.9 7.2 6.8 7.1 7.1 6.8 7.1 9 6.8 7.0 6.4 6.6 6.9 7.3 i 9 7.2 6.7 7.1 6.9 7.0 7.3 6.6 7.0 6.5 6.5 6.8 6.8 6.7 6.5 7.0 6.4 6.7 6 . 6 6.7 6.9 9 5.8 6.3 6.4 6.7 6.0 5.7 6.6 1102 Mfflpwf Sanitized Does not contain TSCA Cffl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ DuPont-4739 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: VII-0 Dose: 1000 mg/kg/day Animal Pup Number Sex 1 2 Pup Number 567 8 9 10 11 12 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 3 7.0 7.3 7.5 7.1 7.5 7.0 7.4 7.4 6.0 9 6.5 6.2 6.2 3 6.5 7.0 6.8 5.9 6.2 5.7 7.0 9 6.3 6.2 6.3 6.7 6.2 6.6 6.1 3 9 5.9 5.9 5.8 6.1 6.1 5.8 6.1 5.9 5.6 5.7 6.0 6.0 6.1 5.7 3 6.3 6.6 6.7 6.2 6.5 9 3 6.1 5.8 6.2 6.0 6.3 5.7 6.1 6.2 6.5 6.7 6.3 6.5 7.0 6.5 6.3 6.5 9 6.4 5.7 6.5 6.2 6.0 6.0 3 9 7.2 6.6 7.9 7.2 7.3 6.7 7.0 6.8 5.5 7.3 6.2 5.9 5.6 4.2 6.2 3 9 3 6.1 6.5 6.0 5.7 6.1 6.5 6.1 5.5 6.2 5.8 6.0 6.0 5.9 5.9 7.1 5.7 7.3 6.4 6.9 5.3 6.0 5.6 6.5 6.0 5.2 9 3 9 3 9 6.2 5.4 5.9 5.7 6.5 6.1 6.7 6.4 6.1 5.9 6.7 6.3 6.0 5.9 6.3 6.3 5.9 5.7 5.9 6 . 0 6.8 6.7 6.6 5.8 6.5 7.0 6.7 6.6 6.9 6.9 6.9 6.5 6.3 6.5 6.8 6.0 5.2 6.6 1103 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 0 Animal Number 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 Pup Sex 3 9 3 9 3 9 3 9 3 9 S 9 3 9 3 9 3 9 3 9 Group: VIII-0 l234 6.2 6.1 4.8 6.5 5.8 5.7 5.9 5.3 7.8 7.5 7.1 6.8 6.7 6.6 6.4 5.6 6.0 6.4 6.6 6.4 6.2 6.2 5.5 5.4 5.5 6.0 6.5 6.5 5.1 5.3 5.8 5.9 7.1 8.4 7.6 7.4 6.7 7.1 6.6 7.0 6.8 7.2 7.2 6.5 6.6 6.7 6.7 6.2 6.8 7.3 5.9 6.1 6.0 5.9 6.5 5.8 6.7 6.2 6.7 6.5 6.4 6.7 6.6 Dose: 1000 mg/kg/day Pup Number 5 6 7 8 9 10 6.2 6.0 5.6 5.5 5.8 5.7 6.4 5.6 5.5 8.1 7.2 7.4 6.9 6.9 6.7 7.6 7.0 6.0 6.2 5.5 5.9 6.0 5.6 6.2 6.2 6.3 5.3 5.7 7.6 5.8 6.3 6.0 7.0 6.3 6.2 6.3 7.0 6.3 6.3 6.3 6.6 5.6 6.4 6.1 6.5 5.8 6.9 6.3 6.4 6.2 5.9 6.2 6.5 DuPont-4739 11 12 6.4 5.3 1104 Company SanlUzed. not contain TSCA CBt 2) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: II-O Dose: 0 mg/kg/day DuPont-4739 Animal Pup Number Sex 1 2 641345 641236 641337 641328 641310 641324 641371 641332 641358 641389 3 12.1 9 10.3 3 10.4 9 9.5 3 12.8 9 13.5 3 14.6 9 12.9 3 10.4 9 11.2 3 12.0 9 13.6 3 11.5 9 9.6 3 10.7 9 10.0 3 9 3 9 10.8 11.0 10.9 9.0 13.2 14.2 12.6 13.7 9.8 10.3 12.5 12.0 9.0 9.8 9.9 9.9 3 11.9 11.0 11.1 9.7 14.7 14.2 15.1 13.5 10.5 10.7 13.0 9.5 9.8 10.1 9.4 10.0 4 11.4 11.4 11.7 9.2 14.8 13.7 13.9 10.9 11.2 13.6 13.3 11.5 9.2 10.5 9.1 Pup Number 56 11.4 9.6 11.3 10.5 13.1 11.6 11.4 10.1 8.3 13.3 13.1 11.4 11.2 11.6 13.1 11.3 8.1 9.5 9.3 12.7 9.5 10.5 11.1 7 10.3 10.0 9.5 11.8 11.7 10.3 10.8 8 9.4 11.6 14.2 9.4 10.2 9.3 9 10.4 11.6 9.8 10.2 10 10.7 7.9 11.6 1105 CwjpMf SanSirod. Bom Ml eonfain TSCACBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Group: II-0 Dose: 0 mg/kg/day Pup Number Pup Sex l 2 3 4 5 6 7 8 <? 15.0 14.6 12.7 2 13.5 14.3 14.1 3 2 9.9 10.4 10.4 10.7 10.7 9.9 9.4 9.5 8.8 8.8 8.5 9.8 8.6 3 2 3 11.1 11.0 11.6 11.4 11.4 11.1 11.2 11.6 9.7 11.4 11.4 11.0 10.3 12.0 11.2 10.8 11.1 12.4 11.6 12.9 12.4 12.2 12.1 12.0 2 11.3 11.4 11.4 11.2 11.0 11.5 3 2 3 12.5 12.6 11.8 10.0 11.0 11.9 11.2 11.8 10.6 12.6 11.0 10.1 11.5 10.8 11.4 10.9 10.9 9.7 9.8 2 3 2 3 2 3 2 9.5 11.9 9.1 12.6 11.9 11.5 11.2 11.0 8.3 11.0 11.6 10.5 11.5 10.8 9.6 10.2 8.6 12.7 10.6 10.8 12.2 9.4 9.3 9.2 10.3 11.0 12.3 12.6 10.3 10.8 10.4 11.7 11.5 10.0 10.7 10.5 9.9 11.5 11.3 11.0 10.5 9.6 9.6 11.7 11.1 7.5 10.7 10.5 11.8 12.1 3 2 9.2 10.1 8.2 10.2 9.5 9.2 8.8 8.1 7.5 8.1 9.6 9.1 8.6 9 DuPont-4739 10 11 8.4 ; 1106 ompany Sanitized. Does not contain TSCA BI J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Preculling GROUP: IV-0 DOSE: 50 MG/KG/DAY DuPont-4739 Pup Number Animal Pup Number Sex 1 2 3 4 5 6 7 8 641378 641263 641297 641304 641274a 641351 641272 641258 641276a 641350 3 9 9.9 '10.3 10.5 10.4 10.9 11.6 10.5 11.5 10.5 10.5 9.9 10.1 10.9 9.3 8.0 10.5 9.6 10.0 10.0 9 9.6 10.0 9.5 9.1 9.3 9.8 9.2 3 11.7 12.6 13.1 12.5 12.4 13.0 9 11.2 11.6 12.4 12.3 12.2 11.2 9.9 3 16.6 9 16.0 15.5 15.5 12.7 15.2 9 a 9 9.4 9.8 9.0 8.6 10.0 9.4 8.8 10.2 9.2 9.9 9.5 9.2 9.5 9.6 3 9 11.5 12.6 11.4 12.2 12.4 12.6 11.2 11.3 ' 12.0 11.4 11.2 12.2 10.2 9 11.0 10.8 11.5 11.6 9.8 11.6 11.4 11.5 8.5 12.0 11.0 10.9 11.1 9.1 3 9 3 9 12.0 10.0 11.3 12.2 11.6 10.1 11.6 10.1 9.0 10.6 11.1 10.6 10.9 9.7 10.7 9 9.5 9.0 10.3 10 9.7 10.2 1107 Company Sanitized. Does not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: IV-0 Dose: 50 mg/kg/day Animal Number 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Pup Number Pup Sex i , 2 3 4 5 6 7 8 9 10 S 12.6 12.3 00 r-4 13.0 9 12.0 10.8 10.0 a 10.4 10.6 10.4 10.0 9.4 8.7 10.7 9.9 9 9.4 10.5 11.0 9.4 10.1 9.4 8.8 9.3 7.3 9.7 a 10.3 11.2 11.4 11.3 10.0 11.1 11.4 10.1 9 9.6 10.5 10.6 9.9 10.4 10.4 a 9 12.2 11.7 12.0 12.6 10.9 12.0 11.5 11.3 12.0 11.2 8.9 11.7 11.5 11.1 a 9 12.1 11.0 11.8 12.3 11.2 10.3 11.5 9.5 12.0 10.7 10.9 11.1 10.3 a 10.1 9.0 10.0 9.8 9.9 10.1 9.4 9 8.8 9.0 9.1 9.4 11.0 9.2 9.7 9.3 a 9.9 10.7 10.0 10.4 10.3 11.0 9.6 10.3 9 a 8.1 10.0 9.4 9.5 10.8 9.9 11.3 12.7 11.3 12.8 12.5 12.3 11.3 10.5 12.1 12.9 9 a 11.9 11.7 12.0 10.6 11.5 12.2 12.2 12.4 12.5 11.0 12.2 9 10.8 11.3 11.0 12.1 12.1 11.6 11.2 a 9 9.5 11.0 9.7 10.2 9.9 10.7 9.9 10.4 10.0 9.4 10.0 9.1 9.2 10.2 )> __ _ ;" ~ ' " 1108 Company Sanitized. Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Animal Number 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392-k; c 641360 Group: VI-0 Pup Sex l 2 3 8 10.4 10.9 10.4 2 9.7 10.0 10.8 8 2 8 2 8 2 8 11.6 11.8 12.1 2 11.0 10.9 10.5 8 10.9 10.0 9.9 2 10.2 9.6 10.3 8 13.3 13.5 12.4 2 12.3 13.0 10.8 8 10.5 10.7 10.5 2 10.1 9.6 9.9 8 6.8 6.5 6.4 2 6.3 7.2 6.4 8 11.4 11.8 12.1 2 11.4 11.2 9.7 Dose: 250 mg/kg/day Pup Humber 4567 T O io.7 -- 10.0 9.4 9.9 10.1 8 -- 9.3 10.4 10.7 10.9 9.7 13.5 12.0 9.7 9.3 7.1 6.3 10.1 11.4 10.1 10.4 9.5 9.5 12.9 11.9 9.5 6.8 10.9 11.2 10.1 9.4 12.4 9.6 6.9 10.9 11.1 10.8 12.2 5.9 11.9 10.4 10.2 6.6 11.8 11.1 11.4 1109 Company Sanitized. Does no! con!ai CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: VI-0 Dose: 250 mg/kg/day Pup Humber Animal Number Pup Sex 1 2 3 4 5 6 7 8 9 10 11 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 3' 9 3 9 3 9.6 9.6 10.8 9.2 9.1 9.4 10.5 9.0 8.9 10.3 9.3 9 9.0 9.5 7.5 10.1 3 9 3 9.9 9.0 9.6 8.9 10.6 8.4 9.7 10.0 10.7 9.5 8.8 9 9.0 8.5 10.2 7.5 8.8 3 14.1 11.7 14.7 13.9 13.0 14.2 13.9 9 14.1 13.9 13.5 11.8 3 9 3 12.3 12.0 11.8 12.1 12.5 11.4 11.3 12.7 9 12.0 11.8 11.7 10.8 12.1 3 11.9 11.6 11.3 11.2 12.1 11.5 9 10.8 10.3 11.3 11.9 10.3 11.1 11.2 11.3 3 11.4 11.4 11.7 11.2 11.0 10.9 9 11.0 11.4 10.5 11.8 10.0 10.4 10.6 12 9.1 1110 Company Sanitized Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-D av Gavaae Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Number Pup Sex 1 2, 3 4 5 6 7 8 9 10 3 13.6 12.6 13.3 12.9 13.4 12.7 13.5 13.6 11.4 11.6 2 11.6 13.0 9.3 9.4 11.3 11.3 10.3 9.3 10.5 2 10.6 10.6 11.3 10.9 10.3 11.1 11.1 a 2 8.7 9.1 9.8 10.1 8.9 9.3 9.0 7.3 8.9 8.9 8.5 8 .b 3 10.9 10.6 10.9 11.8 11.7 2 a 10.5 10.1 10.9 10.5 10.6 11.5 10.3 11.5 11.2 10.7 10.9 10.1 10.1 10.0 12.1 11.6 2 10.0 10.3 9.3 10.0 10.5 10.6 a 10.4 10.7 10.7 10.0 11.1 10.2 10.5 11.3 2 11.3 8.6 9.0 9.0 10.4 7.1 9.5 a 8.2 9.1 9.7 10.1 10.2 5 9.9 9.8 9.0 8.9 9.1 10.2 10.0 9.5 9.7 a 10.8 11.9 11.3 11.5 11.3 10.3 10.0 10.2 10.7 9.6 2 a 10.4 11.0 9.2 10.9 9.1 10.2 9.6 7.7 10.6 10.0 11.3 10.1 2 a 2 10.3 10.7 9.4 10.1 12.1 11.4 9.0 12.3 11.7 9.2 11.5 10.8 8.3 10.8 11.3 10.3 9.4 11.9 10.0 11.6 11.8 9.3 11.3 11.0 11.1 10.4 11 9.2 12 8.7 mi Company Sanitized. Does not c H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Animal Number 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 Group: VTII-0 Dose: 1000 mg/kg/day Pup Sex 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 Pup Number 123 567 8 8.7 6.8 11.1 7.6 10.3 10.4 9.8 8.8 10.3 10.8 8.6 9.9 9.4 9.2 8.4 9 9.3 10.6 10.0 10.5 10.1 10.7 8.8 10.5 10.2 10.5 9.8 10.1 10.3 12.2 10.1 10.5 10.4 10.6 10.2 10.1 10.1 10.8 10.5 11.4 9.6 10.6 9.1 10.9 8.3 9.5 8.9 11.8 10.9 12.5 11.8 10.1 9.6 10.3 10.8 9.8 8.6 12.4 9.8 12.2 12.3 10.0 9.6 10.0 10.8 10.5 9.4 12.1 10.5 12.8 11.3 9.5 10.1 10.2 10.0 10.4 10.1 11.4 11.1 12.7 12.0 9.9 9.4 9.8 10.6 9.6 10.0 12.0 10.6 11.8 9.3 8.8 9.7 9.9 9.5 9.6 11.0 11.3 9.6 9.1 10.6 10.6 10.5 12.0 9.8 10.2 11.3 10.3 10.7 9.7 9.6 10 7.3 11.6 9.7 9.9 10.4 11 8.4 12 9.5 1112 Company Sanitized. Does not contain TSC G81 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling GROUP: II-O DOSE: 0 MG/KG/DAY Animal Number 641345 641236 641337 641328 641310 641324 641371 641332 641358s 641389s Pup Sex 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 2 $ 2 l 10.8 11.0 10.9 9.0 12.8 13.5 14.6 12.9 9.8 11.2 12.0 12.0 11.5 8.1 9.5 10.0 Pup Number 234 11.9 11.4 11.1 9.2 13.2 14.2 12.6 13.5 10.9 10.3 12.5 12.7 9.8 10.5 11.1 9.9 11.4 11.4 11.7 10.5 14.7 14.2 15.1 13.9 11.4 11.2 13.0 11.8 11.5 10.3 10.8 10.0 11.6 10.3 10.1 10.7 14.8 13.7 13.1 11.6 11.2 13.6 14.2 11.3 9.8 10.2 9.1 DuPont-4739 1113 wmpf SanlNzed. Does not conta'n tsoq ^gg H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Individual Pup Weights (grams): Fy Generation Lactation Day 4 Postculling Group: II-O Dose: 0 mg/kg/day Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Pup Sex 1 3 15.0 9. 13.5 3 9.9 9 9.4 <3 11.1 9 11.0 3 12.4 9 11.3 3 12.5 9 11.0 3 11.4 9 11.0 3 11.9 9 9.1 <5 12.6 9 10.6 3 11.5 9 10.8 3 9.2 9 8.8 Pup Number 234 14.6 14.3 10.4 8.8 11.0 10.3 11.6 11.4 12.6 11.2 10.9 9.6 8.3 11.0 12.7 11.5 10.0 12.6 8.2 7.5 12.7 14.1 10.4 9.8 11.4 11.2 12.4 11.2 11.8 11.8 9.7 9.4 10.2 9.2 10.3 11.3 11.0 10.7 10.2 9.6 10.7 8.6 11.1 10.8 12.1 11.5 10.6 9.8 10.3 9.3 10.5 11.7 11.8 7.5 10.5 9.5 9.1 DuPont-4739 1114 Company Sanitized. Dees not cnmta'r* *S'V H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group : IV-0 Animal Number 641378 641263 641297 641304 641274a 641351 641272 641258 641276a 641350 Pup Sex 3 9 3 ? 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 1 9.9 10.5 9.6 10.0 12.6 11.6 16.6 16.0 9.8 8.6 12.6 12.6 11.0 8.5 10.0 10.6 Dose: 50 mg/kg/day Pup Number 234 10.3 10.1 10.0 9.3 13.1 12.4 11.5 10.9 10.0 9.2 12.5 12.3 9.5 8.0 9.9 12.4 11.2 5 15.5 15.5 12.7 9.0 9.9 11.4 11.3 10.8 12.0 10.2 9.5 12.2 12.0 11.5 11.1 9.2 9.5 12.4 11.4 9.8 9.1 11.3 11.1 12.2 10.9 11.6 9.7 DuPont-4739 1115 Company Sanitized. Does not contain TSCA C8I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Postculling Group : 0 Animal Number Pup Sex 641376 , 641315 641286 641231 641338 641318 641373 641365 641348 641323 S 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 d 9 l 12.6 12.0 10.4 11.0 10.3 10.5 12.2 11.3 12.1 11.5 9.0 8.8 9.9 10.0 12.7 11.9 10.6 10.8 11.0 10.4 H <i Dose: 50 mg/kg/day Pup Number 234 12.3 10.8 10.6 10.1 11.4 10.6 11.7 11.2 11.0 9.5 10.0 9.0 10.7 9.5 11.3 11.7 12.2 11.3 9.7 10.0 11.8 10.0 9.4 9.4 11.1 9.9 12.0 8.9 11.8 12.0 9.8 9.1 10.3 10.8 12.8 12.0 12.4 11.0 9.9 9.4 13.0 8.7 9.7 11.4 10.4 12.6 11.1 12.3 11.1 9.9 9.7 11.0 9.9 10.5 11.0 12.1 10.7 9.2 5 12.1 DuPont-4739 1116 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains): Fi Gnration Lactation Day 4 Postculling Group: VI -0 Dose: 250 mg/kg/day Animal Number Pup Sex 1 Pup Number 23 4 641271 6412803 6412523 641386 641277 641233 641238 641235 641392-k' c 641360 S 10.9 10.4 10.3 10.7 5 9.7 10.0 10.8 9.3 3 9 s 5 3 9 3 11.6 10.1 11.2 10.4 ? 10.9 10.5 10.7 10.4 3 10.9 9.5 10.8 10.2 $ 9.6 10.3 9.7 9.4 3 13.5 12.4 13.5 12.9 9 13.0 12.0 11.9 12.4 3 10.5 10.7 10.5 9.7 9 10.1 9.3 9.5 9.6 3 6.8 6.5 6.4 6.9 9 6.3 7.2 6.4 6.3 3 11.4 11.8 12.1 10.1 9 11.4 11.2 11.4 11.4 DuPont-4739 1117 Company Sanitized. Does not contain TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group: VI-0 Dose: 250 mg/kg/day Animal Number 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 Pup Sex a 9 a 9 a 9 a 9 a 9 a 9 a 9 a 9 a 9 a 9 i 9.6 9.0 9.6 9.0 14.7 14.1 12.1 12.0 11.9 10.8 11.4 11.0 Pup Number 23 9.2 9.1 9.5 7.5 10.6 10.2 13.0 13.9 8.4 7.5 14.2 13.5 12.5 11.8 11.6 11.9 11.4 11.8 11.4 11.7 11.3 10.3 11.7 10.0 4 8.9 10.1 9.7 8.8 13.9 11.8 11.3 10.8 11.2 11.1 11.0 10.4 DuPont-4739 1118 Company Sanitized. Does not eorrtatr* '"soft H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Postculling Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Sex l Pup Number 234 13.6 12.9 13.4 12.7 9 11.6 13.0 3 11.3 11.3 10.3 10.5 9 10.6 10.6 10.9 11.1 3 8.7 9.1 9 7.3 8.9 8.5 9.2 3 10.9 10.6 10.9 11.8 9 10.1 10.9 10.5 10.6 3 11.2 10.7 10.9 12.1 9 10.3 10.0 10.5 10.6 3 10.7 10.0 10.2 11.3 9 8.6 9.0 9.0 9.5 3 8.2 9.1 9.7 10.1 9 9.8 9.0 9.5 9.7 3 11.9 11.5 11.3 10.2 9 10.4 11.0 9.2 3 9.1 10.2 9.6 11.3 9 10.3 10.1 8.3 9.3 3 10.7 11.5 10.8 11.6 9 11.7 11.9 11.8 11.0 6 11.4 DuPont-4739 1119 Cwnpany SanRfeed. Does no! contain tsca H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Postculling Group: VTII-0 Animal Number 641254 641242a 641284 641230 641273a 641296 641248 641370 641243 641329 Pup Sex 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 Dose: 1000 mg/kg/day Pup Number 1234 6.8 7.6 10.3 10.4 8.6 9.9 9.2 8.4 10.5 10.0 10.5 10.2 12.2 10.1 10.5 10.3 10.6 10.8 10.1 10.4 10.1 10.6 10.5 10.1 9.5 8.9 12.4 9.8 12.5 12.3 10.1 9.6 10.6 10.8 10.5 9.4 12.1 10.5 12.2 11.3 10.0 10.1 10.2 10.0 10.4 10.0 11.4 11.3 12.8 11.8 9.5 9.1 9.6 10.6 9.6 9.6 12.0 9.7 12.7 11.3 9.3 10.3 10.4 9.9 DuPont-4739 1120 cM8pi? Santesd. Boss nocontain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 7 Group: IX-0 Dose: 0 mg/kg/day Animal Number Pup Sex 641345 641236 641337 641328 641310 641324 641371 641332 641358a 641389a 3 9 3 9 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 1 18.2 18.2 17.8 15.3 20.3 19.2 21.7 20.4 18.6 17.8 22.3 19.0 16.3 18.2 16.5 17.2 Pup Number 2 34 18.7 16.6 19.4 18.1 19.5 20.2 22.0 20.3 15.2 18.0 21.5 20.4 20.1 15.0 16.4 15.2 17.5 18.9 16.3 14.5 21.2 20.5 18.8 19.6 16.2 16.7 20.4 21.4 19.8 17.5 17.7 16.6 18.6 17.4 14.2 17.1 19.6 20.0 20.4 17.8 17.6 21.0 23.3 17.9 17.6 17.1 15.5 DuPont-4739 1121 Company Sanitized. Does not eonfafn TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams) : F3. Gnration Lactation Day 7 Group : II--0 Animal Number, 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Pup Sex 1 3 20.8 9 20.1 3 16.6 9 14.6 3 18.6 9 18.8 3 20.0 9 18.9 < 19.0 9 18.1 3 15.7 9 17.9 3 16.5 9 16.5 3 21.2 9 18.2 3 17.5 9 14.7 3 16.0 9 15.0 Dose: 0 mg/kg/day Pup Number 234 21.5 20.9 16.2 13.7 18.5 17.1 19.6 18.0 19.6 17.1 19.0 14.6 14.2 16.7 20.3 20.4 18.6 16.0 13.9 15.1 18.9 20.6 17.2 15.4 18.3 18.3 19.6 18.2 19.0 18.8 17.9 15.9 16.5 16.1 21.0 20.2 11.5 17.1 14.7 14.3 16.7 16.6 19.2 18.3 18.8 18.3 16.6 17.1 19.7 18.0 17.7 19.8 15.0 17.3 15.1 12.4 5 DuPont-4739 1122 Cosnpany Sanitized Does not contain TSCA Cel H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations . Individual Pup Weights (grains): Fi Generation Lactation Day 7 Group: IV-0 Dose: 50 mg/kg/day Animal Number 641378 641263 641297 641304 641274a 641351 641272 641258 6412763 641350 Pup Sex ? 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 1 16.3 17.0 17.1 16.2 19.2 17.8 25.5 24.8 15.9 15.7 17.3 18.7 19.2 14.0 19.4 17.7 Pup Number 234 16.4 17.1 15.9 15.7 18.4 18.1 16.8 13.8 16.0 16.3 18.2 19.0 18.9 13.6 15.4 16.6 19.0 18.7 23.1 24.7 20.5 15.0 16.3 19.4 19.8 18.4 18.8 15.6 13.8 19.5 18.0 16.9 20.1 16.8 15.2 20.2 17.3 19.2 15.9 16.8 17.6 18.6 18.1 19.3 15.9 DuPont-4739 1123 'Company Sanitized Does not contain TSC CB^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group: IV-0 Dose: 50 mg/kg/day Animal Number 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Pup Sex l Pup Number 234 3 18.8 17.1 18.6 16.0 2 13.2 18.3 16.8 3 16.9 15.1 15.8 17.5 2 16.7 17.7 16.7 15.5 3 18.4 17.1 17.3 16.1 2 16.5 16.4 16.4 17.5 3 18.5 19.9 18.8 20.0 2 14.6 18.0 18.5 17.5 3 19.6 19.4 19.7 18.2 2 19.8 18.8 16.1 18.8 3 16.6 16.3 16.1 15.1 2 12.9 13.7 16.1 14.6 3 16.0 15.8 14.8 16.0 2 15.7 15.2 14.8 15.3 3 18.1 18.3 18.5 21.5 2 18.7 17.7 18.7 3 22.1 19.1 19.2 20.7 2 20.3 18.8 19.3 18.4 3 16.8 18.1 17.1 16.6 2 15.7 17.5 15.6 16.7 DuPont-4739 1124 Company SanWzed. Does nof confab Tera H-24616: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Individual Pup Weights (grams): Fi Generation Lactation Day 7 G r o u p : V I - 0 Animal Number 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392^'c 641360 Pup Sex 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 Dose: 250 m g / k g / d a y 1 17.1 14.9 Pup Number 23 16.0 15.7 17.0 16.1 4 17.0 17.0 18.6 17.8 16.0 16.0 20.7 18.9 15.0 15.0 19.5 17.3 17.3 17.0 21.3 20.1 16.0 14.7 17.6 17.8 16.9 14.9 20.7 20.5 17.1 14.7 17.0 18.1 16.4 14.6 19.3 18.9 16.2 16.4 18.1 18.2 19.1 18.3 19.2 18.1 17.1 18.0 DuPont-4739 1125 wpaWSanitized. Does not contain TSCR H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation ' Lactation Day 7 G r o u p : V I -0 Animal Number 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 Pup Sex 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 Dose: 250 mg/kg/day Pup Number l2 3 4 16.4 16.6 16.5 16.4 15.9 17.6 15.2 13.1 16.2 13.5 21.3 18.6 13.2 14.6 20.0 20.6 14.9 12.5 21.2 20.8 14.9 14.8 20.1 21.4 18.5 18.3 17.8 16.2 18.9 17.8 19.0 18.7 18.1 17.5 19.2 19.4 19.6 19.8 17.6 18.2 18.8 18.7 18.1 17 .7 18.5 15.9 18.5 16.6 DuPont-4739 1126 Company Sanitized. Does not contain TSCCB 3 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________ Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Sex 1 Pup :Number 234 3 20.7 20.0 20.9 21.3 17.9 20.1 2 20.3 18.4 3 18.3 17.2 17.9 19.4 ? 18.0 18.3 17.2 18.3 3 15.2 16.3 $ 15.5 16.2 15.3 13.6 3 18.1 18.1 19.5 17.9 2 16.5 18.0 17.8 17.5 3 19.6 16.5 17.3 17.5 2 17.1 17.1 15.5 17.7 3 17.8 16.2 17.8 16.9 2 14.8 14.3 14.8 15.5 3 15.3 14.2 14.4 13.0 2 13.6 15.1 15.5 14.5 3 19.2 18.8 19.0 15.8 17.0 2 17.3 14.8 17.3 3 15.8 18.1 18.0 16.3 2 14.1 17.8 17.3 16.0 3 18.5 17.9 19.6 19.8 2 20.1 21.5 17.5 18.8 DuPont-4739 1127 Company Sanitized, Does not contain TSCA CRf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams) : F]_ Gnration Lactation Day 7 Group : VIII -0 Dose : 1000 mg/kg/day Animal Number 641254 641242s 641284 641230 641273s 641296 641248 641370 641243 641329 Pup Sex 6 9 S 9 a 9 s 9 a 9 a 9 a 9 a 9 a 9 a 9 i 13.4 16.5 16.8 18.2 17.0 16.3 16.1 15.8 18.9 15.9 20.5 18.3 16.5 15.0 17.8 17.1 Pup :Number 23 18.3 15.8 12.7 14.7 20.0 17.3 16.4 16.8 17.1 15.7 17.0 16.5 16.4 15.3 19.1 18.6 20.1 20.1 16.9 16.2 16.4 17.1 17.9 15.4 18.2 16.9 20.2 18.8 15.5 16.9 17.3 16.9 4 18.6 12.6 16.9 17.1 16.9 16.8 17.2 16.6 19.0 15.9 20.3 19.1 16.4 17.7 16.7 16.3 DuPont-4739 1128 Company Sanitized Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: II-O Dose: 0 mg/kg/day Animal Number 641345 641236 641337 641328 641310 641324 641371 641332 641358s 641389s Pup Sex 2 2 S 2 6 2 S 2 <? 2 6 2 2 $ 2 q 2 1 38.4 38.2 37.9 32.3 38.7 37.5 43.7 40.3 38.2 36.3 40.7 42.4 40.3 36.5 38.5 36.1 Pup Number 234 37.4 38.0 38.7 35.2 40.0 36.7 39.4 40.1 35.9 35.5 43.4 42.8 38.7 33.0 37.4 35.9 36.3 35.2 37.8 36.1 39.5 38.6 41.9 40.8 36.8 36.6 41.8 40.1 41.0 36.9 34.9 34.0 39.3 35.7 34.0 37.6 37.7 39.1 39.8 32.2 37.1 39.7 38.9 35.4 38.0 35.9 35.5 DuPont-4739 1129 GwnpsMf SanHfeed. Does not eonialn TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group : II--0 Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Pup Sex l 3 37.3 9 35.7 3 34.5 9 30.7 3 41.7 9 41.4 3 39.9 9 37.7 3 41.4 9 38.8 3 38.7 9 32.8 3 39.5 9 37.7 3 36.3 9 37.1 3 28.8 9 35.7 3 33.4 9 32.5 Dose: 0 mg/kg/day Pup number 234 36.3 37.3 35.0 30.1 41.9 41.3 40.2 38.5 43.1 38.8 37.4 38.5 43.0 35.9 40.6 38.4 34.7 35.2 35.7 33.5 33.6 36.9 32.9 34.0 41.5 39.3 40.0 38.2 41.6 38.6 36.2 35.1 33.8 40.0 41.4 38.3 39.2 37.4 32.5 35.9 36.5 32.1 41.8 40.3 38.2 41.1 35.7 35.8 39.1 38.8 41.6 39.0 36.9 38.3 32.9 32.9 5 DuPont-4739 1130 CtoiwpanySanitized. Ooes no m * W n w i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: IV-0 Dose: 50 mg/kg/day Animal Number^ Pup Sex 1 641378 a 36.9 2 36.6 641263 s 35.5 2 35.4 641297 3 38.1 2 36.4 641304 3 49.2 2 46.1 6412743 3 2 641351 3 35.9 2 35.5 641272 3 39.2 2 37.2 641258 3 40.1 2 40.7 641276s 3 641350 2 3 39.2 2 36.8 Pupi Number 234 40.8 34.4 36.8 35.3 37.8 35.6 37.3 37.0 36.4 33.9 37.5 37.6 38.1 37.1 34.4 38.2 37.3 47.3 47.5 45.9 35.0 35.0 40.9 38.6 39.1 40.1 33.6 35.9 42.1 40.7 36.9 35.5 37.3 32.8 40.8 37.8 40.3 31.9 40.9 37.1 39.6 36.2 36.3 36.9 DuPont-4739 1131 Company Sanitized. Does not contain TSCA CI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: IV-0 Dose: 50 mg/kg/day | (I) H Animal Number 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 Pup Sex 1 Pup 23 4 3 36.0 33.8 32.8 35.3 9 34.5 33.4 29.2 3 35.5 38.7 40.9 36.9 9 35.4 38.5 37.6 40.1 3 38.1 36.0 39.7 34.7 9 36.0 35.6 35.8 35.8 8 37.7 38.3 38.2 38.2 9 37.0 32.3 36.9 35.2 8 38.9 39.9 38.2 39.1 9 34.3 40.0 37.8 38.0 8 33.6 34.7 33.9 32.1 9 34.8 30.8 30.7 34.1 3 35.4 36.2 35.1 34.8 9 33.9 33.7 34.1 34.0 8 38.8 37.6 38.5 41.8 9 37.1 37.0 38.9 3 38.6 42.3 42.4 39.5 9 39.2 37.6 37.9 39.9 3 36.2 36.1 36.9 37.8 9 34.9 35.6 33.7 36.0 DuPont-4739 1132 Company Sanitized. Does not contain TSCA CBI H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group : VI-0 Animal Number 641271 641280a 641252a 641386a 641277 641233 641238 641235 641392^ , c 641360 Pup Sex 3 2 3 9 3 2 3 2 3 2 3 9 3 2 3 9 3 2 3 2 Dose: 250 mg/kg/day 1 35.6 32.7 Pup Number 23 32.3 34.5 34.5 34.3 4 34.3 29.6 40.0 36.9 36.3 33.4 42.3 40.1 32.7 35.1 38.0 38.8 37.6 34.2 40.8 39.9 35.4 30.3 38.3 38.2 35.2 34.7 38.2 39.2 37.2 34.0 40.1 38.5 36.2 35.7 41.2 35.8 32.7 40.0 38.2 36.8 38.4 40.1 38.8 38.5 38.0 DuPont-4739 1133 Sanftfeed. Does no eonfarj tca CR H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: VI-0 Animal Number 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 Pup Sex 9 3 9 3 9 3 9 3 9 9 3 9 9 3 9 3 9 Dose: 250 mg/kg/day Pup Humber 123 4 38.6 37.1 34.5 39.5 36.6 32.9 34.7 26.3 30.5 30.7 42.3 41.5 34.1 33.7 39.6 36.7 34.4 30.2 42.7 42.1 34.0 34.2 41.5 41.3 38.5 42.2 39.1 39.1 37.7 39.0 38.5 38.2 39.3 38.1 39.2 39.5 39.8 40.7 39.0 36.1 40.1 35.7 40.6 37.8 38.5 35.1 39.3 37.5 DuPont-4739 1134 QMpatif Sanitized. Doe not contain TSC CRI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Sex l Pup Number 234 ,6 44.3 39.9 39.6 43.4 9 38.2 43.1 3 37.5 34.4 35.2 34.0 9 35.6 33.4 32.3 34.9 3 33.0 34.3 9 33.0 34.5 30.8 33.9 3 34.9 35.3 35.3 36.5 9 34.8 34.9 32.4 33.6 3 39.0 37.8 36.6 37.0 9 36.4 35.7 35.4 36.6 3 38.9 38.3 38.9 37.2 9 35.9 34.8 35.7 35.4 3 35.4 33.4 32.2 36.5 9 35.6 32.8 36.1 35.0 3 38.3 39.1 35.5 33.8 9 36.2 35.9 32.3 3 36.1 31.0 34.3 34.9 9 32.1 32.0 34.9 32.9 3 40.2 39.3 40.3 39.8 9 39.7 39.4 39.9 37.3 5 6 DuPont-4739 1135 Does not contain Tgc, nn) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains): Fi Gnration Lactation Day 14 Group: VIII-0 Dose: 1000 mg/kg/day Animal Pup Number Sex l Pup Number 23 4 641254 641242 641284 641230 641273s 641296 641248 641370 641243 641329 3 31.6 31.7 39.7 40.8 $ 36.8 36.6 31.9 34.3 3 9 3 38.0 37.6 38.2 42.5 9 37.4 35.6 36.4 37.5 3 34.9 33.6 34.5 34.0 9 34.1 33.3 33.6 33.1 3 9 3 36.9 35.2 34.7 34.3 9 34.4 33.0 36.1 33.7 3 40.6 39.2 40.7 42.3 9 36.4 35.3 39.3 35.5 3 43.1 42.0 40.4 41.9 9 39.9 41.6 39.2 39.9 3 35.3 35.9 33.8 36.4 9 36.7 34.1 32.9 34.8 3 36.6 34.4 33.9 35.5 9 33.8 35.3 37.1 33.6 DuPont-4739 1136 Company Sanitized. Does net contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group : II -0 Animal Pup Number Sex 1 641345 641236 641337 641328 641310 641324 641371 641332 641358a 641389a S 65.4 2 61.5 6 58.1 2 58.3 S 59.4 2 62.8 S 65.0 2 63.6 $ 56.4 2 54.3 S 69.5 2 67.9 6 64.5 2 58.4 54.8 2 57.9 2 2 Dose: 0 mg/kg/day Pup Number 234 59.1 59.9 64.8 60.4 59.8 58.7 69.7 63.9 59.2 55.9 70.4 65.5 66.6 58.4 57.9 57.2 60.1 57.6 65.8 55.9 63.9 59.0 68.7 59.8 52.6 65.8 67.9 61.3 63.1 57.4 56.5 53.2 65.6 62.1 59.3 51.2 56.8 60.8 63.4 57.4 60.0 65.9 66.1 53.0 60.9 54.9 56.6 5 60. DuPont-4739 1 1137 ^wpsstf SanRfeed. Does not co n iai H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________ ;__ Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: II-O Dose: 0 mg/kg/day Animal Number 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 Pup Sex l Pup Number 234 6 64.3 59.1 63.7 9 62.2 62.0 60.1 53.6 58.7 50.5 52.5 9 51.0 48.2 50.0 50.7 67.0 66.9 70.0 66.7 9 64.3 67.4 63.0 63.7 66.0 68.3 66.2 9 61.1 59.8 60.8 61.2 S 68.6 68.4 64.7 9 62.5 56.9 58.6 57.0 57.4 61.5 57.9 56.8 9 53.7 62.7 55.4 58.1 61.0 59.2 52.6 61.8 9 60.1 55.6 59.0 60.9 67.7 59.0 65.0 66.9 9 58.8 59.9 59.4 59.7 62.8 57.5 60.5 60.9 9 46.1 61.6 57.1 54.5 6 51.7 54.8 53.4 55.7 9 54.6 50.7 49.5 51.9 DuPont-4739 1138 nPny SanHfeed. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ___________ Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: IV-0 Animal Number Pup Sex l 641378 641263 641297 641304 641274a 641351 641272 641258 641276s 641350 3 60.6 9 59.5 3 57.2 9 54.2 3 62.2 9 60.0 3 82.3 9 72.2 3 9 3 56.1 9 53.7 3 61.2 9 53.8 3 60.2 9 53.1 <5 9 3 56.7 9 57.1 Dose: 50 mg/kg/day Pupi Number 234 58.0 56.0 56.2 55.2 62.3 63.9 59.8 57.5 56.1 54.6 61.5 62.4 58.5 52.7 54.2 59.9 59.6 72.4 76.3 73.9 51.0 65.3 52.5 54.7 60.1 62.4 64.2 67.0 51.4 52.9 59.6 55.3 65.3 57.0 50.2 49.4 60.3 52.1 63.0 66.3 64.4 58.1 61.5 57.7 61.0 52.5 DuPont-4739 1139 " *pai1ySan!*feeef. Does no?contain TSCA CS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: IV-0 Dose: 50 mg/kg/day Animal Number 641376 . 641315 641286 641231 641338 641318 641373 641365 641348 641323 Pup Sex 3 2 a 2 3 2 3 2 3 2 <3 2 3 2 3 2 3 2 3 2 1 54.4 57.5 68.7 63.2 66.1 59.1 59.0 54.3 64.0 59.8 51.9 55.7 61.7 58.7 63.8 58.8 70.3 65.9 57.5 55.1 Pup Number 234 56.7 46.1 63.0 61.6 62.3 61.5 63.2 51.8 63.9 57.0 57.2 55.6 60.7 57.1 59.6 60.2 72.9 63.7 57.5 52.1 54.7 49.4 69.0 67.8 64.5 63.3 61.5 57.1 62.4 60.0 56.9 51.5 62.5 58.0 62.5 55.7 63.7 58.9 53.3 54.4 55.0 62.5 65.6 57.6 57.9 62.3 56.8 58.3 57.7 59.0 51.4 56.9 56.3 61.7 60.1 63.0 54.3 55.4 DuPont-4739 1140 Coiwp9ny SanRfeed. es not contain TSC rm H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: VI -0 Animal Number 641271 641280s 641252s 641386s 641277 641233 641238 641235 641392h'c 641360 Pup Sex 3 9 3 9 3 9 3 9 3 9 d 9 3 9 3 9 3 9 3 9 Dose: 250 mg/kg/day Pup Number 12 3 57.8 58.3 52.5 46.9 56.0 53.2 4 57.4 52.7 56.3 58.6 56.0 51.2 61.1 61.8 59.2 48.0 59.4 58.3 60.3 54.4 61.7 63.4 54.2 55.0 59.6 56.2 56.3 52.6 70.1 61.0 57.4 51.6 61.2 58.4 58.0 56.0 68.6 53.4 56.0 65.9 61.5 63.2 62.6 66.6 63.1 62.6 64.8 DuPont-4739 1141 Company Sanitized. Does not contain TSC CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 21 Group: VI-0 Dose: 250 mg/kg/day Animal Number 641381s 641333s 641239 641228s 641334 641347 641367s 641303 641339 641316 Pup Sex a 2 a 2 d 2 d 2 d 2 a 2 a 2 a 2 a 2 a 2 i 57.8 58.1 61.4 57.3 72.0 67.3 62.5 58.2 63.7 61.4 60.8 59.2 Pup Humber 23 59.7 60.3 55.6 52.7 58.3 51.1 62.3 61.7 54.6 55.5 69.3 69.0 62.2 61.2 62.0 59.3 63.1 56.7 63.2 64.7 60.5 57.3 63.3 60.5 4 64.0 41.5 59.9 58.9 68.7 64.1 63.3 56.4 60.2 61.9 63.5 60.6 DuPont-4739 1142 Company ianfflzed. Does not contain T8C CSM H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group : VIII-0 Animal Number 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 Pup Sex 1 3 71.3 9 65.4 3 56.4 9 52.4 3 56.6 9 52.0 3 56.3 9 56.0 3 62.5 9 58.2 3 61.6 9 56.5 3 56.0 9 54.6 3 55.6 9 51.8 3 54.9 9 56.8 3 62.9 9 64.9 2 67.5 60.2 54.8 56.9 57.3 52.2 57.6 52.1 58.8 57.6 61.5 53.4 55.2 48.8 62.3 55.9 55.6 58.3 65.3 64.4 Dose : 1000 mg/kg/day Pup Number 34 68.5 64.6 5 64.0 6 62. 56.1 53.7 59.1 54.8 56.7 56.7 54.2 59.7 56.0 61.6 54.1 53.7 54.8 63.6 56.2 58.3 53.2 65.7 60.6 50.0 53.8 52.6 59.9 54.6 57.7 55.3 50.1 52.8 54.8 53.0 53.8 66.3 64.2 62.5 DuPont-4739 1143 t a p a n y Sanitized. Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: VIII-0 Animal Number 641254 641242a 641284 641230 641273a 641296 641248 641370 641243 641329 Pup Sex 9 9 3 9 6 9 3 9 3 9 3 9 S 9 3 9 3 9 1 65.0 51.9 64.7 59.9 55.7 52.3 52.8 50.8 64.7 56.2 62.0 59.0 61.3 54.7 54.3 53.4 Dose: 1000 :mg/kg/day Pup Number 23 53.6 57.7 63.8 56.3 4 53.0 55.6 64.4 62.7 53.6 54.0 62.4 60.4 59.1 54.4 67.0 58.7 55.7 52.7 56.0 50.0 64.8 58.5 69.0 60.9 60.7 55.1 56.8 56.0 56.2 55.0 61.9 58.3 64.4 64.0 57.3 61.0 54.2 50.4 53.0 51.2 63.4 61.2 62.2 56.9 62.5 51.0 55.0 52.3 DuPont-4739 1144 Sompany Sanitized. Dees not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX FF REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION 1145 fowwpany Sanitized. Does not contain TSC CSI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION EXPLANATORY NOTES Footnotes a AH pups were dead prior to lactation day 7. 1146 Company Sanitized. Does not contain TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________DuPont-4739 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fj. GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 641345 641236 641337 641328 641310 641324 641371 641332 641317 641255 641403 641388 641261 641306 641349 641346 641308 641289 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1147 Company Sanitized. Does not contain TSCA ^ 3 ! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F* GENERATION GROUP: IV-0 DOSE: 50 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 641378 641263 641297 641304 641351 641272 641258 641350 641376 641315 641286 641231 641338 641318 641373 DAY 0 1 OF 16 LITTER SUMMARY : 1 641365 641348 641323 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED SWOLLEN HEAD SWOLLEN HEAD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1148 Bfflpwif Sanitized. Does not contain TSCA CI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________ DuPont-4739 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fj. GENERATION GROUP: VI-0 DOSE: 250 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 641271 641277 641233 641238 641235 641392s 641360 641239 641334 641347 641303 641339 641316 - NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1149 Company Sanitized. Does mat contain T9CA CBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fx GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 DAY 21 1 OF 8 LITTER SUMMARY : 1 641284 641230 641296 641248 641370 641243 641329 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED CORNEAL OPACITY LEFT EYE(S) CORNEAL OPACITY NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1150 Company Sanitized. Does not contain TSC CSS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX GG REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS: Fi GENERATION 1151 S w ttteed , D oes m eonaaln TSCA e e i H-24616: Subchronic Toxicity . 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________ REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHTS: Fi GENERATION EXPLANATORY NOTES Notes Day o f weaning = Test Day 1. DuPont-4739 1152 Company Sanitized. Does not contain TSCA CbI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (grams) OF Fj. MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 DAYS ON TEST : ANIMAL NUMBER 644438 644439 644440 644441 644442 644443 644444 644445 644446 644447 644448 644449 644450 644451 644452 644453 644454 644455 1 8 15 22 29 36 43 65.6 59.3 60.8 60.8 57.4 65.9 53.0 54.9 63.7 52.5 66.7 66.2 64.7 56.8 61.8 66.9 60.9 55.7 106.7 101.1 107.5 112.8 97.4 109.5 98.4 96.7 104.5 95.5 108.9 104.9 110.3 99.2 102.7 110.9 114.4 95.0 172.5 163.5 167.0 184.0 159.8 167.0 157 .7 165.5 180.3 153.8 174.1 167.2 174.0 156.7 169.4 183.4 178.1 159.0 227.0 216.1 233.9 264.6 207.5 205.8 219.3 234.0 268.3 215.4 230.5 223.8 237.3 211.7 211.1 254.0 240.8 228.9 299.1 280.0 282.1 336.7 271.3 272.1 281.2 295.6 338.3 281.9 326.2 291.3 297.5 267.7 294.5 308.3 306.3 285.5 365.0 332.9 343.1 413.9 326.4 335.2 347.4 362.0 407.6 341.4 395.3 351.9 354.4 330.7 367.3 363.2 372.2 335.6 404.8 390.2 387.4 477.2 373.4 388.5 398.2 412.6 483.4 389.7 453.8 415.4 398.5 378.2 428.5 401.8 423.0 376.2 1153 Company Sanitized. Does n o t eontasi TSC A CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (grams) OF Fi MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 DAYS ON TEST : ANIMAL NUMBER 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 644522 644523 644524 644525 1 8 15 22 29 36 43 58.5 56.1 59.9 82.3 50.2 60.3 63.0 61.0 55.0 62.5 57.6 62.3 58.3 59.0 56.9 59.4 60.1 54.3 108.9 100.6 113.8 136.3 87.8 107.7 103.8 112.2 96.4 102.0 102.7 107.4 101.3 102.6 103.8 104.7 97.2 105.7 176.8 167.3 175.8 212.1 148.3 172.8 165.3 181.3 156.2 167.2 167.9 185.0 161.8 170.8 163.7 172.5 161.9 175.8 226.7 230.1 259.1 281.5 205.2 239.3 230.1 238.9 200.0 232.5 233.6 259.5 222.8 235.7 220.4 244.8 223.5 207.1 322.9 295.1 328.9 353.5 277.0 299.1 290.6 288.5 262.0 293.7 293.7 322.0 285.2 299.7 271.8 316.2 290.6 305.9 399.2 362.8 392.1 417.7 345.1 360.0 345.4 341.5 319.4 363.3 366.6 361.0 345.5 361.7 317.6 383.4 370.6 367.3 468.4 429.1 459.2 481.4 403.8 413.7 398.1 390.5 368.7 421.3 421.4 422.1 409.3 408.8 361.2 434.3 431.8 428.6 1154 Company Sanitized Does not contain TSCA C H-24616: Subchronic Toxicity . ,^ 90-Dav Gavage Study in Rats with One-Generation Reproduction Evaluations^ INDIVIDUALBODY WEIGHTS (grams) OF Fi MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DuPont-4739 DAYS ON TEST: ANIMAL NUMBER 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 1 8 15 22 29 36 43 61.2 57.4 58.0 68.6 53.4 62.6 64.0 59.9 68.7 63.3 60.2 63.5 103.2 99.4 97.2 114.1 87.6 103.8 108.3 104.0 110.3 111.7 107.5 98.9 162.6 168.7 154.3 184.5 143.2 173.3 172.7 168.9 172.4 180.7 170.9 161.1 224.6 223.9 198.7 236.7 192.6 231.6 243.1 232.1 239.1 250.5 225.3 222.8 282.9 300.1 268.7 329.9 232 '.1 283.3 313.1 293.2 299.5 310.0 307.0 281.3 330.1 374.5 322.5 414.6 276.9 330.8 377.5 356.2 358.6 365.2 372.0 322.6 382.3 425.1 373.6 465.8 314.5 376.5 431.7 379.4 413.9 405.6 428.3 358.5 Company Sanitized, Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF F1 MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 644638 644639 644640 644641 644642 1 8 15 22 29 36 43 62.2 59.1 57.3 53.8 59.9 57.7 50.1 62.5 53.0 66.3 53.0 67.0 55.7 53.0 63.4 62.2 62.5 55.0 116.2 104.2 96.6 91.6 110.7 97.6 80.9 103.3 94.4 112.9 86.5 109.9 98.6 93.1 110.4 113.2 103.8 90.1 185.8 170.4 155.2 149.1 176.4 151.0 135.0 160.4 154.5 174.5 150.9 179.7 157.2 153.0 179.2 183.7 168.6 146.5 261.0 229.1 224.8 207.6 240.7 210.4 193.1 223.9 206.3 241.6 218.9 239.6 195.0 212.2 245.9 251.3 230.9 204.2 325.6 300.3 287.9 265.6 304.6 268.4 244.0 282.1 295.2 308.1 287.3 319.0 262.0 266.6 306.8 312.8 289.7 248.1 401.7 355.0 345.9 316.9 364.1 320.4 304.0 336.4 361.7 366.9 351.7 398.1 330.2 329.9 367.4 366.7 346.4 297.0 457.2 406.2 395.2 366.6 413.2 365.8 344.3 389.9 423.3 414.0 403.9 458.3 382.7 379.9 424.3 413.0 402.4 344.9 j) 1156 Company Sanitized. Does not contain TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL. BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 DAYS ON TEST : ANIMAL NUMBER 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 644712 644713 644714 644715 1 8 15 22 29 36 43 62.1 51.2 59.0 63.4 60.0 66.1 60.9 56.6 60.1 50.7 63.7 61.4 63.9 58.1 60.9 59.7 54.5 51.9 102. 1 93. 4 97. 0 102. 5 98.,0 97.,5 105..2 95..7 101..5 96..8 98 .4 101 .8 102 .3 97 .0 91 .8 107 .1 92 .7 88 .7 152. 0 136. 9 134. 6 149. 5 149. 0 140.,0 144.,5 148..9 142..3 145,.1 146..3 150,.2 154 .7 146 .1 138 .5 156 .2 137 .0 128 .5 181. 8 161. 3 184. 5 198. 6 182. 0 178.,8 191.,2 190,.3 178..3 185..1 191,.6 184,.0 187 .8 179 .5 174 .6 194 .4 169 .6 165 .8 202.6 189.9 212.7 217.8 202.4 206.8 221.0 219.3 196.9 205.9 227.3 207.0 205.0 208.0 202.7 216.8 194.2 181.8 221.5 209.9 233.9 249.9 223.5 230.5 253.5 246.5 220.4 233.7 245.2 228.8 229.1 225.5 217.8 232.4 212.3 212.0 238.0 231.1 252.9 278.4 242.6 260 .'4 271.4 256.9 240.4 254.9 270.7 245.0 245.0 231.3 252.9 245.6 230.6 213.1 1157 Company Sanitized. Does not contain TSCA OB* H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 644784 644785 644786 644787 1 ' 8 15 22 29 36 43 52.7 51.0 59.6 65.3 49.4 52.1 66.3 52.5 49.4 65.6 57.9 56.8 57.7 51.4 56.3 55.7 63.0 55.4 93.3 86.3 91.8 103.9 88.4 85.9 100.1 96.0 85.4 101.3 101.5 101.1 92.5 89.3 102.7 93.5 101.7 99.4 140.8 129.2 136.8 158.3 141.0 127.5 145.8 146.3 124.0 151.6 148.2 155.0 134.0 143.0 149.1 140.5 162.4 154.3 173.7 163.4 170.6 204.3 177.3 165.3 175.3 176.8 157.2 165.4 186.8 193.4 164.4 186.8 174.4 177.2 189.9 198.4 206.8 184.9 201.1 231.7 206.8 190.2 203.9 201.1 184.3 174.7 214.1 217.2 174.6 211.7 213.4 200.0 231.8 225.8 225.1 197.3 223.8 256.1 233.8 205.5 223.1 218.1 207.5 204.8 246.9 238.6 190.9 240.9 228.1 222.1 270.1 259.2 249.7 225.9 251.0 285.1 249.0 231.3 241.4 235.2 222.1 216.1 269.1 257.1 206.5 272.6 255.4 235.3 302.8 273.1 1158 Skm m ' <* "Ol COM . TSCA e e l H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DAYS ON TEST : ANIMAL NUMBER 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 1 8 15 22 29 36 43 52.7 58.4 56.0 61.0 50.6 64.8 41.5 58.9 64.1 56.4 61.9 60.6 92.5 99.2 91.4 96.1 88.5 103.6 73.2 96.8 113.0 100.4 103.5 93.6 145.7 151.8 139.6 140.1 137.5 158.3 115.1 139.5 166.5 146.4 157.5 139.0 183.9 197.9 175.7 177.5 170.8 204.3 147.4 169.1 206.5 180.6 204.9 170.8 186.3 228.1 200.5 201.3 193.3 227.4 174.6 208.3 235.9 202.0 228.7 186.4 206.2 254.2 228.8 220.2 215.2 257.4 196.2 224.5 275.6 218.0 252.8 198.4 211.4 283.7 251.3 234.9 238.5 285.8 216.3 243.7 312.7 233.5 287.7 215.3 1159 ffligMf Sanitized, Does not contain Tt eaj H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (grams) OF Fi FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 DAYS ON TEST : ANIMAL NUMBER 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 644903 644904 644905 644906 1 8 15 22 29 36 43 60.2 54.8 50.0 52.6 54.6 55.3 52.8 56.2 53.8 64.2 55.6 58.7 52.7 51.2 61.2 56.9 51.0 52.3 100.5 95.1 88.0 86.3 93.5 87.7 87.3 86.5 89.4 104.5 90.2 97.9 96.9 87.4 97.8 101.7 85.5 89.4 151.1 141.8 129.3 130.6 142.2 122.6 134.2 139.2 135.1 154.2 136.6 153.0 150.8 134.9 138.0 147.5 134.3 136.5 186.3 175.0 177.7 168.3 175.2 154.1 171.3 179.3 176.9 183.5 172.8 187.9 187.5 161.2 174.8 178.9 172.8 161.6 207.6 185.1 206.2 189.3 197.8 172.7 195.7 204.2 202.0 214.1 201.7 214.4 213.2 182.6 198.4 197.5 205.3 174.2 239.9 198.4 227.7 216.1 216.7 188.0 239.7 226.5 229.8 242.6 223.4 243.7 251.9 204.3 222.1 220.5 231.5 211.4 258.0 203.9 247.9 228.0 228.6 210.0 249.7 248.5 245.0 257.8 241.6 265.0 259.8 229.4 242.5 238.1 248.5 218.9 1160 iRSfflVanf Sanitized. Does not contain TSCA eert H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX HH REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION 1161 MspMf SanHlzed. Bees not contain TSC CBf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. DuPont-4739 1162 ewpanf Sanitized. Does not contain TSCCBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644438 644439 644440 644441 644442 644443 644444 644445 644446 644447 644448 644449 644450 644451 644452 644453 644454 644455 1-8 8-15 15-22 22-29 29-36 36-43 41.1 41.8 46.7 52.0 40.0 43.6 45.4 41.8 40.8 43.0 42.2 38.7 45.6 42.4 40.9 44.0 53.5 39.3 65.8 62.4 59.5 71.2 62.4 57.5 59.3 68.8 75.8 58.3 65.2 62.3 63.7 57.5 66.7 72.5 63.7 64.0 54.5 52.6 66.9 80.6 47.7 38.8 61.6 68.5 88.0 61.6 56.4 56.6 63.3 55.0 41.7 70.6 62.7 69.9 72.1 63.9 48.2 72.1 63.8 66.3 61.9 61.6 70.0 66.5 95.7 67.5 60.2 56.0 83.4 54.3 65.5 56.6 65.9 52.9 61.0 77.2 55.1 63.1 66.2 66.4 69.3 59.5 69.1 60.6 56.9 63.0 72.8 54.9 65.9 50.1 39.8 57.3 44.3 63.3 47.0 53.3 50.8 50.6 75.8 48.3 58.5 63.5 44.1 47.5 61.2 38.6 50.8 40.6 1163 Consparsf SanllfeecL Does not sontein TSCA CSI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj. MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 644522 644523 644524 644525 1-8 8-15 15-22 22-29 29-36 36-43 50.4 44.5 53.9 54.0 37.6 47.4 40.8 51.2 41.4 39.5 45.1 45.1 43.0 43.6 46.9 45.3 37.1 51.4 67.9 66.7 62.0 75.8 60.5 65.1 61.5 69.1 59.8 65.2 65.2 77.6 60.5 68.2 59.9 67.8 64.7 70.1 49.9 62.8 83.3 69.4 56.9 66.5 64.8 57.6 43.8 65.3 65.7 74.5 61.0 64.9 56.7 72.3 61.6 31.3 96.2 65.0 69.8 72.0 71.8 59.8 60.5 49.6 62.0 61.2 60.1 62.5 62.4 64.0 51.4 71.4 67.1 98.8 76.3 67.7 63.2 64.2 68.1 60.9 54.8 53.0 57.4 69.6 72.9 39.0 60.3 62.0 45.8 67.2 80.0 61.4 69.2 66.3 67.1 63.7 58.7 53.7 52.7 49.0 49.3 58.0 54.8 61.1 63.8 47.1 43.6 50.9 61.2 61.3 1164 Company Sanitized. Does not contain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj. MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 1-8 8-15 15-22 22-29 29-36 36-43 42.0 42.0 39.2 45.5 34.2 41.2 44.3 44.1 41.6 48.4 47.3 35.4 59.4 69.3 57.1 70.4 55.6 69.5 64.4 64.9 62.1 69.0 63.4 62.2 62.0 55.2 44.4 52.2 49.4 58.3 70.4 63.2 66.7 69.8 54.4 61.7 58.3 76.2 70.0 93.2 39.5 51.7 70.0 61.1 60.4 59.5 81.7 58.5 47.2 74.4 53.8 84.7 44.8 47.5 64.4 63.0 59.1 55.2 65.0 41.3 52.2 50.6 51.1 51.2 37.6 45.7 54.2 23.2 55.3 40.4 56.3 35.9 1165 .wpaiBySanitized, Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 644638 644639 644640 644641 644642 1-8 8-15 15-22 22-29 29-36 36-43 54.0 45.1 39.3 37.8 50.8 39.9 30.8 40.8 41.4 46.6 33.5 42.9 42.9 40.1 47.0 51.0 41.3 35.1 69.6 66.2 58.6 57.5 65.7 53.4 54.1 57.1 60.1 61.6 64.4 69.8 58.6 59.9 68.8 70.5 64.8 56.4 75.2 58.7 69.6 58.5 64.3 59.4 58.1 63.5 51.8 67.1 68.0 59.9 37.8 59.2 66.7 67.6 62.3 57.7 64.6 71.2 63.1 58.0 63.9 58.0 50.9 58.2 88.9 66.5 68.4 79.4 67.0 54.4 60.9 61.5 58.8 43.9 76.1 54.7 58.0 51.3 59.5 52.0 60.0 54.3 66.5 58.8 64.4 79.1 68.2 63.3 60.6 53.9 56.7 48.9 55.5 51.2 49.3 49.7 49.1 45.4 40.3 53.5 61.6 47.1 52.2 60.2 52.5 50.0 56.9 46.3 56.0 47.9 1166 Company Sanitized. Does not contain TSCA C5I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 644712 644713 644714 644715 1-8 8-15 15-22 22-29 29-36 36-43 40. 0 42 .2 38. 0 39. 1 38..0 31..4 44..3 39.,1 41..4 46..1 34 .7 40 .4 38 .4 38 .9 30 .9 47 .4 38 .2 36 .8 49. 9 43. 5 37. 6 47. 0 51. 0 42.,5 39.,3 53..2 40..8 48,.3 47 .9 48 .4 52 .4 49 .1 46 .7 49 .1 44 .3 39 .8 29. 8 24. 4 49. 9 49. 1 33. 0 38. 8 46.,7 41..4 36,.0 40,.0 45..3 33 .8 33 .1 33 .4 36 .1 38 .2 32 .6 37 .3 20.8 28.6 28.2 19.2 20.4 28.0 29.8 29.0 18.6 20.8 35.7 23.0 17.2 28.5 28.1 22.4 24.6 16.0 18.9 20.0 21.2 32.1 21.1 23.7 32.5 27.2 23.5 27.8 17.9 21.8 24.1 17.5 15.1 15.6 18.1 30.2 16.5 21.2 19.0 28.5 19.1 29.9 17.9 10.4 20.0 21.2 25.5 16.2 15.9 5.8 35.1 13.2 18.3 1.1 I 1167 C om p any S a n itized . Does not contain TSC CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj. FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 644784 644785 644786 644787 1-3 8-15 15-22 22-29 29-36 36-43 40.6 35.3 32.2 38.6 39.0 33.8 33.8 43.5 36.0 35.7 43.6 44.3 34.8 37.9 46.4 37.8 38.7 44.0 47.5 42.9 45.0 54.4 52.6 41.6 45.7 50.3 38.6 50.3 46.7 53.9 41.5 53.7 46.4 47.0 60.7 54.9 32.9 34.2 33.8 46.0 36.3 37.8 29.5 30.5 33.2 13.8 38.6 38.4 30.4 43.8 25.3 36.7 27.5 44.1 33.1 21.5 30.5 27.4 29.5 24.9 28.6 24.3 27.1 9.3 27.3 23.8 10.2 24.9 39.0 22.8 41.9 27.4 18.3 12.4 22.7 24.4 27.0 15.3 19.2 17.0 23.2 30.1 32.8 21.4 16.3 29.2 14.7 22.1 38.3 33.4 24.6 28.6 27.2 29.0 15.2 25.8 18.3 17.1 14.6 11.3 22.2 18.5 15.6 31.7 27.3 13.2 32.7 13.9 1168 Comparii' Sanitized. Does not contain TSGA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj. FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 1-8 8-15 15-22 22-29 29-36 36-43 39.8 40.8 35.4 35.1 37.9 38.8 31.7 37.9 48.9 44.0 41.6 33.0 53.2 52.6 48.2 44.0 49.0 54.7 41.9 42.7 53.5 46.0 54.0 45.4 38.2 46.1 36.1 37.4 33.3 46.0 32.3 29.6 40.0 34.2 47.4 31.8 2.4 30.2 24.8 23.8 22.5 23.1 27.2 39.2 29.4 21.4 23.8 15.6 19.9 26.1 28.3 18.9 21.9 30.0 21.6 16.2 39.7 16.0 24.1 12.0 5.2 29.5 22.5 14.7 23.3 28.4 20.1 19.2 37.1 15.5 34.9 16.9 1169 .Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj. FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 644903 644904 644905 644906 1-8 8-15 15-22 22-29 29-36 36-43 40.3 40.3 38.0 33.7 38.9 32.4 34.5 30.3 35.6 40.3 34.6 39.2 44.2 36.2 36.6 44.8 34.5 37.1 50.6 46.7 41.3 44.3 48.7 34.9 46.9 52.7 45.7 49.7 46.4 55.1 53.9 47.5 40.2 45.8 48.8 47.1 35.2 33.2 48.4 37.7 33.0 31.5 37.1 40.1 41.8 29.3 36.2 34.9 36.7 26.3 36.8 31.4 38.5 25.1 21.3 10.1 28.5 21.0 22.6 18.6 24.4 24.9 25.1 30.6 28.9 26.5 25.7 21.4 23.6 18.6 32.5 12.6 32.3 13.3 21.5 26.8 18.9 15.3 44.0 22.3 27.8 28.5 21.7 29.3 38.7 21.7 23.7 23.0 26.2 37.2 18.1 5.5 20.2 11.9 11.9 22.0 10.0 22.0 15.2 15.2 18.2 21.3 7.9 25.1 20.4 17.6 17.0 7.5 1170 Bern m itm M n tsca cm H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX II REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL FOOD CONSUMPTION: Fj GENERATION 1171 CoffljMny Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________ REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL FOOD CONSUMPTION: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. DuPont-4739 1172 Company Sanitized, Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fj. MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644438 644439 644440 644441 644442 644443 644444 644445 644446 644447 644448 644449 644450 644451 644452 644453 644454 644455 1-8 8-15 15-22 22-29 29-36 36-43 13 .8 14. 2 14. 6 15. 7 1 2 .9 14..5 13..1 13 .2 13 .4 13..0 13 ,.6 14..4 14 .7 12 .7 13 .4 15 .0 14 .8 12 .7 22.0 21.9 21.6 22.2 20.4 22.4 19.9 20.5 22.6 19.1 21.1 19.4 21.8 20.6 20.0 24.6 22.1 21.0 25. 8 25. 6 25. 7 27.,9 24.,3 19..1 25..3 25,.4 28 .2 22 .9 25 .8 23 .8 25 .4 23 .8 22 .3 27 .2 27 .4 25 .6 31.5 28.3 27.6 32.1 27.2 28.0 29.9 29.2 32.5 27.6 34.1 28.5 30.8 29.0 29.9 30.1 32.9 28.1 31.3 30.3 30.5 35.1 32.0 29.3 30.7 32.3 33.0 29.3 36.0 32.0 30.2 31.4 32.3 32.7 33.9 30.8 31.6 31.1 31.0 37.1 30.1 29.4 30.7 35.0 39.6 28.7 36.7 35.1 30.4 32.8 34.8 32.0 32.6 29.6 1173 Sanitized. Does no? contain TSCA C81 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fj. MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 644522 644523 644524 644525 1-8 8-15 15-22 22-29 29-36 36-43 16.0 12.9 16.1 16.7 11.9 15.2 14.0 15.7 12.1 13.0 13.2 13.2 13.7 12.8 13.5 14.8 12.5 15.1 24.7 21.7 23.1 25.7 19.8 22.1 20.7 22.6 18.9 20.0 21.2 22.3 20.9 20.0 20.8 23.1 20.5 23.9 27.5 26.0 29.4 28.2 23.3 26.1 27.8 26.9 18.4 25.8 26.3 28.1 24.5 25.4 24.5 27.1 25.8 26.5 36.3 31.2 33.8 32.5 29.5 30.0 29.4 27.9 26.6 28.3 29.9 30.8 28.8 30.6 27.3 31.9 30.2 37.2 37.7 34.0 35.0 34.5 30.6 32.1 31.2 29.0 29.0 30.3 31.7 25.9 31.6 32.2 28.1 34.0 35.7 34.4 40.6 37.3 39.6 35.9 31.8 33.8 31.2 28.5 29.7 33.1 31.6 34.3 34.2 34.2 28.5 33.8 37.7 35.2 1174 Company Sanitized . D o e s not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 . 1-8 1 2 .0 1 2 .,7 1 2 ..6 15..8 1 2 .6 13..5 14,.8 17..8 13 .6 15 .2 14 .0 15 .4 8-15 15-22 22-29 29-36 36-43 19..1 2 2 .,8 19..0 24..0 19..7 18,.1 22 .8 18 .9 22 .8 23 .6 22 .6 21 .7 22.3 25.8 22.5 27.3 22.7 23.9 27.0 24.7 26.5 28.3 25.8 26.9 25.8 33.0 28.7 35.1 26.9 27.1 31.3 27.9 28.8 30.6 32.4 29.5 26.8 34.5 29.0 39.0 29.6 27.0 34.7 30.5 31.8 31.6 33.6 29.7 28.4 34.8 29.8 36.8 29.8 28.3 35.0 28.3 31.7 31.3 34.9 28.3 1175 Company Sanitized. Does not contain tra .3 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 644638 644639 644640 644641 644642 1-8 8-15 15-22 22-29 29-36 36-43 14.8 13.5 13.9 11.7 14.4 13.1 10.9 13.3 12.6 16.0 11.4 13.9 13.1 12.1 15.1 14.2 13.3 12.9 22.3 21.8 22.7 20.1 22.5 18.7 16.7 21.1 20.8 21.3 20.5 21.5 18.5 18.3 22.9 23.3 19.8 18.2 29.3 26.5 26.4 21.7 27.4 23.5 25.4 24.7 24.8 26.2 25.7 27.7 19.9 21.5 27.7 27.7 23.8 23.4 32.6 32.5 30.1 25.4 31.1 28.3 23.6 28.0 32.5 29.2 32.2 32.6 30.6 24.8 31.7 32.6 26.3 24.6 35.6 31.9 31.7 27.4 34.1 27.9 27.9 29.9 34.0 31.9 34.1 34.3 34.2 27.0 33.9 34.0 27.9 27.3 36.8 34.3 32.5 28.6 31.3 29.2 28.7 16.9 37.4 31.1 35.5 35.8 36.9 27.9 33.4 33.2 29.2 29.2 1176 Company Sanitized, Does not eontain TSC CSl H-24616: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx FEMALE RATS GROUP: II-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 644712 644713 644714 644715 1-8 8-15 15-22 22-29 29-36 36-43 13.8 14.2 14.0 13.0 18.1 14.3 9.1 13.5 17.5 13.5 12.9 14.0 12.9 12.1 10.3 14.4 10.7 12.4 19.5 18.1 18.9 19.6 18.0 18.2 20.3 19.8 17.7 19.3 18.7 18.8 18.2 19.2 16.8 20.7 17.4 17.3 20.0 17.8 18.5 21.8 20.7 19.5 23.5 23.6 18.5 21.3 21.1 19.9 19.0 21.5 20.0 21.2 18.3 19.4 20.6 21.6 22.5 22.2 21.4 21.5 23.8 24.1 19.1 22.0 23.9 20.8 19.7 22.8 20.7 22.2 19.5 19.9 19.1 20.8 22.2 23.8 19.8 22.5 25.4 24.2 19.7 23.3 21.9 20.1 20.6 21.4 18.1 21.1 19.6 20.5 19.4 21.4 25.4 24.9 20.6 23.5 26.5 23.6 18.9 22.6 23.2 19.3 20.2 23.7 21.8 19.9 19.1 20.9 1177 Company Sanitized. Does not contain TSC CB5 H-24616: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DAYS ON TEST: 1-8 ANIMAL NUMBER 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 644784 644785 644786 644787 12.7 12.5 12.2 12.7 11.6 10.6 12.8 11.7 . 13.7 13.1 13.7 13.4 11.9 11.5 14.1 13.0 13.6 13.3 8-15 15-22 22-29 29-36 36-43 19.3 17.3 18.3 21.5 19.9 16.4 16.9 19.2 15.2 19.5 18.9 19.3 17.5 17.5 19.9 19.0 20.9 20.3 22.9 19.3 18.4 23.3 22.5 18.8 18.3 20.1 16.0 18.0 20.0 3.6 19.3 20.5 20.9 20.4 22.8 22.4 24.1 19.2 20.4 23.5 21.8 19.7 20.4 19.1 18.2 17.2 21.8 20.6 18.1 20.4 22.2 21.6 23.6 22.6 23.0 18.4 21.8 24.5 23.2 19.6 20.7 19.1 18.6 19.8 23.2 23.7 19.2 22.4 21.5 21.0 25.3 24.0 24.6 19.6 21.3 26.2 22.6 21.5 22.0 20.8 18.1 18.8 23.6 24.2 18.9 24.2 23.3 20.7 27.9 24.4 1178 Company Sanfeed. Does not contain TSC CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 . 1-8 12.3 12.2 13.2 12.8 12.0 13.1 12.7 13.4 15.1 14.0 13.7 11.8 8-15 15-22 22-29 29-36 36-43 19.5 18.0 18.6 17.9 17.0 19.0 18.5 16.8 21.3 20.5 20.2 17.7 21.8 21.3 20.3 20.7 19.5 22.1 21.2 19.0 22.7 20.8 23.1 19.1 18.9 22.0 21.1 21.8 19.6 22.3 21.8 20.6 24.4 20.3 24.4 18.2 18.8 21.2 20.6 20.7 19.7 23.9 23.9 20.4 29.6 21.4 23.4 17.3 17.3 24.0 22.2 21.7 20.6 25.3 25.5 22.8 28.9 21.9 23.9 17.5 1179 Company Sanitized. Does not contain TSCA CTii H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 644903 644904 644905 644906 . 1-8 12.5 13.5 13.0 12.1 12.2 12.4 11.8 11.6 13.1 14.0 11.7 14.0 14.1 11.8 13.2 13.5 12.0 11.9 8-15 15-22 22-29 29-36 36-43 18.0 18.2 17.9 16.6 17.9 16.2 17.0 19.5 17.5 20.1 17.7 20.1 19.4 17.6 17.0 18.2 17.9 17.4 19.5 18.8 20.7 18.1 18.9 17.3 19.5 23.9 20.2 19.9 19.8 23.2 21.6 18.6 20.7 19.4 20.8 18.1 21.0 18.8 22.5 18.3 19.6 18.2 21.1 19.5 22.4 20.9 21.9 23.4 21.7 19.9 9.7 19.3 24.0 17.8 22.9 18.2 23.2 19.8 19.2 17.8 23.1 24.9 23.0 20.9 21.6 24.4 25.2 19.5 21.2 20.6 23.7 19.5 23.1 16.3 22.2 18.8 18.4 18.3 20.3 24.3 22.8 21.8 21.3 24.1 23.8 20.2 21.2 19.7 24.1 18.9 1180 Company Sanitized. Does not contain TSCA C H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX JJ REPRODUCTIVE TOXICOLOGY EVALUATIONS INDIVIDUAL CLINICAL OBSERVATIONS: Fi GENERATION 1181 Company Sanitized. Does not contain TSCAC B S H-24616: Subchionic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY EVALUATIONS DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS: F, GENERATION EXPLANATORY NOTES Notes Day o f weaning = Test Day 1. 1182 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 644438 644439 644440 644441 644442 644443 . 644444 644445 644446 644447 644448 644449 644450 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 HEAD CAUGHT IN CAGE AS CLOSING DOORa PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 30 28 29 30 25 15 29 33 31 27 27 30 28 30 30 28 29 30 25 15 29 33 31 27 27 30 28 30 a This clinical observation is not reported in the Summary Data Tables. 1183 Company Sanitized. Does not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644451 644452 644453 644454 644455 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 28 28 28 28 27 27 31 31 28 28 1184 Company Sanitized. Does not contain TSCA C H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 28 28 28 28 27 27 38 38 26 26 28 28 28 28 26 26 27 27 29 29 29 29 28 28 30 30 27 27 1185 Sanitized. D o e s n o t contain TSCA C B l H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644522 644523 644524 644525 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 30 30 28 28 32 32 30 30 1186 .Company Sanitized. Does not contain TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 PREPUTIAL SEPARATION INCOMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 43 43 28 28 28 28 28 28 39 39 28 28 27 27 28 28 29 29 27 27 27 27 29 29 1187 Company Sanitized. Does not contain TSCA OBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 CORNEAL OPACITY LEFT EYE(S ) PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 27 27 30 30 29 29 31 31 29 29 28 28 32 32 29 29 30 30 30 30 1 43 28 28 27 27 33 33 1188 G&snpmySanitized. Does not contain TSCA C? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644638 644639 644640 644641 644642 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 27 27 26 26 27 27 28 28 28 28 i 1189 eimpMif t e A s d Bmm not contain TSC GEI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 20 20 10 10 14 14 11 11 10 10 10 10 11 11 11 11 13 13 13 13 11 11 20 20 12 12 10 10 1190 Company Sanitised. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644712 644713 644714 644715 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 11 11 11 11 15 15 99 1191 Company Sanitized. Does not contain TSCA CSi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY ANIMAL NUMBER , OBSERVATION 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 11 11 10 10 17 17 15 15 20 20 13 13 13 13 13 13 , 15 11 13 15 11 13 19 19 15 15 18 18 1192 Company Sanitized. Does not contain TSCA GBf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644784 644785 644786 644787 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 21 21 18 18 10 10 10 10 1193 Company SanfUwd. Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 11 11 13 13 13 13 13 13 17 17 13 13 21 21 14 14 21 21 10 10 17 17 11 11 1194 Company Sanitised. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 13 13 12 12 16 16 13 13 13 13 20 20 12 12 13 13 99 12 12 15 15 11 11 15 15 10 10 1195 Company Sanitized. Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION 644903 644904 644905 644906 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 43 FIRST DAY LAST DAY OBSERVED OBSERVED 16 16 11 11 11 11 11 11 1196 Company Sanitized. D o es n o t contain