Document qaY9wOE4L1j8njy2p12wVvky5

.iv func'.'* s may Ivspnea, .Itpcnils .noil, itic I cxpo.lisease ..... nine as 13 ...illy, the <1 io 40 .liestos ,3 i-...presses ;l In its ))> inability *vKcn or jftu.up hlood .nihelio. nasally .\.esses ..l icctum | i.i.' asbes... 1967, ih. itiat ex it ini.- male i.mles-- 11 .`i.i. anti t .mcemf ih.' eases tft.nl King.ipalionwith as<iilis were s Insulation ^.ompared ; number SI pnpula- <!w. may i'l nsbesili.ise reii.jllv evi- oecur l usts of wars of Ini dctlinrter minors 1 >.v any iib.'iapy, insults n is in- A zinphosmethyl 113 sufficient at this time to set an exposure stan dard (other than zero) which could assure prevention of mesothelioma in all workers, since the disease may occur following a very limited exposure 20 to 30 years earlier.1 Cigarette smoking is strongly implicated as a cocarcinogen among asbestos workers.3 The . incidence of bronchogenic carcinoma among nonsmoking asbestos workers is not significantly greater than that of nonasbestos workers, while asbestos workers who smoke have a much higher incidence.1 Calculations suggest that cigarette smoking asbestos workers have approximately eight times the risk of developing lung cancer compared with other smokers.' The TLV was established to protect against asbestosis and reduce to an acceptably low risk the development of neoplasms.5 Diagnosis; Signs and symptoms include localized pleural thickenings, which may be come radiopaque through calcification; re strictive pulmonary function; rales, dyspnea, cyanosis, dry cough, and finger clubbing. Differential. Diagnosis: Differentiate from other diseases which are associated with dif fuse infiltration of the lungs: Hamman-Rich syndrome, Loffler's syndrome, fungus infec tions, sarcoidosis, scleroderma, and other rare types ofdiffuse interstitial fibrosis. Differential diagnosis of pleural mesotheli oma should include inflammatory pleurisy, primary lung cancer, and the presence of met astatic disease from a primary tumor else where in the body." Special Tests: Radiography, tuberculin skin test, and sputum culture should be per formed. Treatment; None is specific. Medical Control: Preplacement and annual physical examination, with emphasis on the pulmonary, cardiovascular, and gastrointes tinal systems; chest roentgenograms; lung function tests to include FVC and FEV (I sec.); sputum cytology. dustrial Materials, p. 440. New York: Rcinhold Book Corporation, 1975. 3. Joint ACGIH-AIHA Aerosol Hazards Evaluation Committee: Background doc umentation on evaluation of occupation al exposure to airborne asbestos. Am. lnd. Hyg. Assoc. J.,36:91, 1975. 4. National Institute for Occupational Safety and Health, U.S. Department of Health, Education and Welfare: Criteria for a Recommended Standard. Occupa tional Exposure to Asbestos, (HSM) 72-10267. Washington, D.C.: U.S. Gov ernment Printing Office, 1972. 5. A.C.G.I.H.: Asbestos. Documentation of the TLVs for Substances in Workroom Air. ed. 3, pp. 17-19. Cincinnati, 1976. Supplemental 6. Selikoff, I. J., Churg, J., and Hammond, E. C.: Asbestos exposure and neoplasia. JAMA, 188:22,1964. 7. Selikoff, 1. J., Hammond, E. C., and Churg, J.: Asbestos exposure, smoking and neoplasia. JAMA,204:106,1968. 8. Selikoff, I. J., Hammond, E. C., and Seidman, H.: Cancer risk of insulation workers in the United Stales. Biological Effects of Asbestos, p. 209. Lyon: WHO International Agency for Research on Cancer. 1973. 9. Wright, G. D.: Asbestos and health in 1969. Am. Rev. Rcspir. Dis., 100:467, 1969. 10. Stumphius, J., and Meyers, P. B.: Asbes tos bodies and mesothelioma. Ann. Occup. Hyg., 11:283, 1968. 11. Champion, P.: Two cases of malignant mesothelioma after exposure to asbestos. Am. Rev. Respir. Dis., 103:821, 1971. 12. Legha, S. S., and Muggia, F. M.: Pleural mesothelioma: clinical features and thera peutic implications. Ann. Intern. Med., 87:613, 1977. References Principal 1. Department of Labor: Occupational ex posure to asbestos. Federal Register, 40:47652,1975. 2. Sax, N. I.: Dangerous Properties of In AZINPHOSMETHYL (CH30),P(S)SCH2(N3C70) 1977 TLV 0.2 mg/m3 Synonyms: O.O-Dimethyl S(4-oxo-l,2,3 -bcnzotriazin-3(4H)-yImeihyl) phosphoro- Rep# X.r'j _, ,v..^_, GLEASON-000061