Document qaXR0w4VgzZrRZ6voO8g96kEK

AttacShtmuednitess taondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 AR226 O13 Perfluorooctane Sulfonate-Related Compounds Pertwee AcuteToxicity 1) FAimnearlicRaep,oIrntc,.,A3cuMteReDfeerrmeanlceToNxoi.ciTt-y41S0t2u,dySainmpRalbebiNtos.,TH8a3z7e3lt8o9n-4L1ab0o7r5a4to,rJiaensuary21, 1988 2) FInicn.a,l3ReMpoRretf,erAecnucteeNOor.alT-T4ox1i0c2i,tSyaSmtpuldey Nino.RaTt8s,37H3a8z9el-t4o1n0L7a5b4o,raJtaonruiaersyA2m5e,ri1c9a8,8 3) FLianbaolraRteoproirets,APmreirmiacray,EIynce.,I3itMatRieonf/eCroernrcoesNioo.n STt-u4d10y2i,n SRaabmbpiltes,NoH.azTel8t3o7n389-410 754, January 20, 1988 4) FLianbaolraRteoproirets,APmreirmiacray,DIencr.m,a3lMIrRreiftaetrieonnc/eCoNroro.siTo-n41S0t2u,dySainmpRalbebiNtos.,TH8a3z7el3t8o9n-410 754, January 21, 1988 Genotexicity 1) MMuitcargoesnoimcietRyeTveesrtsweiMtuhtTa-t6io3n57Asisnatyh,eCSoalmmionngelHlaazl--eEtsocn,heIrnicc.h(iaCHcVo)l,i|PMraojmemcatlNioa.n- 17387-0-409, 3M Reference No. T-6357, FC-120, April 1, 1996 2) MHauztlaegteonni,ciItnyc.T(eCstHVo)n,TP-r6o3j5ec7tiNnoa.n 1I7n3V8i7-v0o-M40o9u,s3eMMiRcerfoenruecnlceeusNoA.ssTa-y6,35C7o,mFiCn-g120, April 23,1996, Pharmacokinetic Studies 1) oFfinTa-l6R0e5p2oritn,RAanbabliyttsi,caHlazRleeptoornt WainsdcoSnisnignl,e-IDnoc.s,ePDreojremcatlNoA.bsHoWrpIti63o2n/9T-o1x3i5c,it3yMStudy Reference No. FC-120, T-6052 (0.02 % in water), November 20, 1995 2) SHaiznlgelteo-nDoWsiesDcoenrsmianl,IInntc.r,aPvreonjoeucstPNhoa.rmHaWcoIki6n3e2t9i-c13S4t,ud3yMofRTe-fe6r0e5n2ceinNRoa.bbTi-t6s0,52 (0.02% in water), November 20, 19995 . -6- 005112 Attachments to Letter to C. Auer dated May 18, 2000 Studies and Other Information on Certain Perfluorooctane Sulfonate-Related Compounds Pre-1976 Studies (bibliography only) 1) Acute Oral Toxicity Study with T-1019 in Male Albino Rats, Industrial Bio-Test Laboratories, Inc., Project No. 601-05394, 3M Reference No. T-1019, August 6, 1974 2) Skin Irritation, Eye Irritation, Acute Oral LDS0, WARF Institute, Inc., Project No. 4053863, 3M Reference No. T-992, May 24, 1974 3) Acute Oral Cholinesterase Study with T-1019 in Male Albino Rats, Industrial Bio- Test Laboratories, Inc., Project No. 601-05394, 3M Reference No. T-1019, August 6, 1974 ~ 7. 005cq 13 HEEAZLETON eons mencnrc FINAL REPORT BEST COPY AVAILABLE eATaEsEeR6RT. ,pHeRrRNkIieNnGste& MAMUFACTURING COPAY ES asin soveLE: Tein PURCHASE. ORDER NUMBER: TE37389-410 754 Chemie & Bioodia Scionces Division . GECEIVE nz X, aA "c~onXydrEegN)0F2ace: sarPLE ENTERED: REPORT PRINTED: 7190576: 09/258 01/218 ENCLOSED: ACUTE DERMAL TOXICITY STUDY IN RAESITS (GERD GUIDELINES) o k<eyAPersonnel 2 Smreiue! Pethology Comments E Ree t rnenpairtn SSAiiEooEwnSorvekiBecichtaooznnhey dart 00514 @ HAZLEa TONEmemoT anmcane E Chemical & BioMdiaPl SRcienAcesTDivision canpLE NBER: 20905762 sareLe: Toi BEST COPY AVAILABLE" ev PERSONNEL saute Toxicolons SEtoHver 1. Glaze SrCaotEuuinALrLT.adeHiroretosn GFnoaoretn LE.aorHaoiuneartyor Quality assurance SDretira Curley Arndt gnatonial Fathiogs rThomeas sE. Paatnenr,opiPaHtOe SRonbeirrt SBaaltaveen supervisor nDeeennniesLeHaodtefrman fGnrooneepe Moesahaede rar stasator final Usterinacion SCiindnyt3o. nCarayb, eOU G0C515 E@ HAZLETON orm smear a TI RCehemicial &sBioMeS dical T SciencA es Division Carle BER: 70905762 caries Toa102 Pace 3 BEST COPY AVAILABLE cEco nema screen Do2Bjro0acmtniiveesksset imToonareafnsoirsaeysEscownhteohnmeicsysCtoIespmaiarcraottoiTxoenaiciaitnedyDhaoenvdeehrleoilpnmaatanietveeasrassGkniugnidetiolr.irnitehtseancy Ba ha or Enemients: TosPSthynSMiaetnetraisbtesSscriTap-t4i1to0n2s DGaorhkeoarmbesreleiqnuidesponsibility for Storage and Retention: ATeheTrlteiienroenddmatnaeeorotnieiasloittwyashdisettloerreemdinaaotteioornonso.ms tSemOpeRraEtuSre. Safety Precautions: NVTooerhemensh. BSReernnadan)ssaairrndsg BODrproeocresadtatitrnoigsn.tPewraoerect.eadisueereted secording TesSStraamAhnioianmt,aali mvaasYtcoaatuannttgneeasdld.ullettaosidroseabarbiieotrss1,SofpirntohevCidNoeesuraZsoceaeaeotlstasonn.nd tocUahgicetoserersint'raadtienmIpiewnerireieruumreA ondARRmtaCeaterm0eisCooimnenASstoSnotdarbIeunr ironeutTRiA onhedFiibnertheRepibGuoMsideChofcoI ,r otnhde Chaerled afnodrToUnse C3% nLvaeemorrtaurdayrEsTbufAtmoiTansaet.etnhryMoLTacrronsvtearamitisintamnoitnnsts.edufreoosnmastuhopenapedrica1d3s.eeRretaobehTdaavasfaovbreroonrmamperanertsraeelnett i nthe TEenedno vSanees union units move" inter Faria bith or atfoatod ne FDti3v2oe5dm7alpeeerraoenadchafoeisveepn'afcaeiemfailreeadndaocfmocstlimTtharote.essdtceedrlsaibnbaainttdsi,ohnaiwnpeieisrgiihoniden:dg bdueTrtesiutnsgenanti2hem0a5l7asbgleasnd a pFoenirelay teu1mSkmeiaeasntow"uirthahmoainunreselmbeeocrmtebrreasr as1naea:5t0pceomrta.eveersspTaohlendisonphgaalveotdaerntretinan'gg:)meedaAscrhbuoprrasbbit's rea insrery 20% 5 tha" toiat Body arace. ReaeSsiaonnnet.foorrraapShpieiecniaearssmaStebileoeancntiotonhne:thaineiHsieos]teosroiifocnaslhloyi,istdheeeNeiwa ZtehealaTnadrdeUnistmeunt of PrafFpariaAtidoDn eofIlTeaAtiMatterSyiTalH: UThedisamHplae uresidasoe aan R receio ved: RAfnSTN 600516 @ HAZLETON sooneones sencanc Chemical & BioMedical Sciences Division SSoT KINSHAR BLVD. + 7.0. BOX 545 + MADISON, WISCONSIN 53707 + PH6O082N47-E471 + TIX T0395 RAZRAL MDS U0 SAMPLE NUMBER: 70905762 caries T-ai02 Togp PAGE 4 'Y AVAILABLE OECD DERMAL SCREEN (CONTINUED) TreTaatmiento:F 2.T0hegrtkeos.t maTtheeriaarleawaosf pappplliiceadtitooneawcahs caonviemraeld'swibatchk aat10ax do1s0e-cm Lgluarneroppiaateeth sreapcau.red Twuietnhty-pfoopuerr hd the backs sere usshed with htoaupers anldateorusrtuherapbpaenddagweisth weSraeranremWorvaepd and lukeusrm fap water and wiped uith dispos- SGholreingpaptehre 2t4o-whelosu.r exCpoolsluarres pwearrieods.ppliad to restrain the test animsls RmaZshooniceforisRobuasteed ofon Adtmheinimsettrhaotdioanf: DraHiizset.orically, this is tha route of Obsm2ei0rn1vu5afteis2o7n5asf:taenrgEa4rcehmhoovuaarnlsimaaolfftewtrahsa teotsbetsstsrmvametadetreirfaiolarl acldtimhnieinciiasnltirtaistaiilgonnsd.eramnedTlhimroitrrytrailtiattyion oTCnlainndSiitcnuagdlywosDsiagysnmsad3e,a.nd7, Stuw1b0isceeaqnuddeani1tl4.yre(Tamhdoeirnngiasnngimofaelnsdderawmefartleernoiobrosrnei)rtvaetfdioorndmaoiurletryaelfimotrayd.e Twheeighatnsimawlesre watroekenwsaiggahiand ajtust7 dpraiyosrantdo atteststumdaytertiearlminaaptpiloincatoirona.t deBsotdhy. PatB1h1oloagmyi:meleA,t Subjected 15 suhteutdhyertedrymiinngatioonn,fessturvorivisnugthaannaitmiazlesdueatre teeurtmhiannaattiiozne,d.uere a Gross necropsy examination and all abnormalitiss were sTaevceadr.ded. After necropsy, animals were discarded and no tissues uere StamteitshtoidcawlasMeptehrofdosr:med.Other than avarage body weights, no other statistical Locpaotirotn woifllRawbeDarteatsisnneddFiinnaltheRepaorrcth:ivesTheof rHaLuA.data and a copy of the final C0651? @ HAZLETON soomwonessvemca ne ra avo 120-XTER WASH WOW ST PROCNhEomoiyoaAl &4B4l+oMeLdXivTalkSolAaGncReAs DWiEvision SAMPLE NUMBER: 70905762 somes Toat02 wage BEST COPY AVAILABLE J ---- Jr-- sumary I TToosrt eRannn"iimmaaelt:s 1ReAtaalnnbiSnRoeasaRaartbcbhhit5sPreo-duNcetws.Zeanlaan.d UDneintveer PA Method of Administration: Dermal pplication Date Tost Started: 11/1687 Date Test Completed: 11/3187 Eutinated Dermal LDS: FMaoleein- CGrrEeanteerrerthahnan2.02.8g/koguof ofbodbyayueiigahrtahe MORTALITY SUMHARY (NUMBER OF DEATHS) DpLoaseey RghoTsuEs We wS e M wr MoDnaee owe nr Ar AECkw 20 0 0 00 00 00 10 00 vo 0 0 150510 Inifaur"ags BBoadey nighi ts (9) Fvooteie 3nleor3 2117a6ms 31567941 600518 @ HAmZiLnE1TOS N woneoWcmAorSeSnnEeR carrie wnsen: Fuse Rhoicm a & iCatAStAns iHihn STCOPY AVAILIBLETM SAMPLE: T-4102 eco oem. seneen B comrinueos Chimica Signs EE Tree Tn amm pfpiepaater rratevitae orlent mLa eStoeloe A mmpFeanrreAedtoreat 502S05%ED5E5bT O4e4s4i e0t0i0i iTai0Tid piosnoS yia 0 daA 0 di 00 Sos Eob0TEbnO EhsobEEbnlEzaaEdzaEaiA izoozsoioiozaaoa: 5p753s 3G3i5Pein3sironaidis idis i4i4ii40i5 dos A + Upon transfarrrineg oniTEnals Steo the necrTaEpsTy aBroea, rtanirnaalaHto.i2305T7e5 a edn eed Renefo esa ont TRA" IEE 05! 00519 @HHSAoAZiZnLLoEEBTETVOO. N7N0. ToOeoRwnTwSeonMesAsSmeOenNncWcaSasGneEeNS OT PCHhOCNehEmeimiccaalTl &&SYoBiMol+MeedTdiXiccaTalloSSccilWenAnccZeesAsDDWiiGvvils0io5onn SerLE WER: 21905762 SarpLE: Toa102 eae 7 PEST COPY AVAILABLE [I ---- cconTiNuED) PaTHOLOGY Doss Lawals 2.0 grkg of body weight Nanoimneatl sex DienTosdtscDiaiyticed Necropsy Comments ness ms oPorriiaarnael msitnasins = browns animal am m= me animal thin. os om - 1a CPaorpiannanla tTahiins = tani animal foes m4 - T PTornainoo tmeednsukiinnfaoir-mmededid)ffurbsoreoalmyn readsosomnren-ts oTA Er tn nasa socoim anrd iSmses + Fs mo 1a nCr oilnonle =Scoopa netaarisnstrhicanl:teaer, ferontthys Poss fF - 14 AA seEnRi ATIUOa-- nNtSnieSrnYs Fist Hi cose FE - 14 SPPaerrrtiaanmaal)ti saStrayinVsTyEm-pidartmokidneb.arlowna;ppears tain fos0 Fa a SSuebcsr utsane eous L1ti3sasune 0nusnedsrnreeadth rentiatin Mikickinest nes Fo 1a SSeuibracmuatttaanesahnuesnskiniVuinedteerrneartehs, Faas Ff - aa . r Saubcuttn aneaous sSkEian unn dsrne gath 00520 E@ HAZLETON como momen ve Ch Chemica& BioMedical Scences Divison cope NBER: 20905762 TORY AALBE SAMPLE: T-4102 - arco ern. soReEn cconTinuED> Rerarencest 1. fOErogoaoEnriesaatStniaodn 3f5o,r55Ec8o1nomic SCooopeeratiHoAn and DeveA lopmente'srGugidelines 2. I ODraaizne,tiJ.Ht.a,d B"ppaEraairssleaorfatttoheereSSha5fee5rtyeSToaftCahnemeicFalFsoodinanFdoodOsr,dDrugs, 3. OECD Principles of Good Laboratory Practice, Annex 2, CADIZ (Final). 4. NIN Publication No. 85-23 (revised 1985). CO05RL Page 9 PHALTAHOLLAOBGYNO.REP7O0R9T05762 Acute Dermal Toxicity Taennd trhaebbirtesmai(nfiinvge maanliemsa,lsfiwveerefeemuatlheasn)atiwzeerde naetcrtohpesiteedr.minOanteiomnaloef dtiheedstoundyt.est FaTrhoeeurodnofseempaalgleeesve7lh,adofdmautylhtioisfpldreeeaptornre,td. faoncdTihegrorossusbacroeuabtssaenreofvoautsviaortniisasbslureeecosorifdzeet.dhefoTtrhreeeaattcerhdeatsaenkdiimnalof skin of one of these appeared to be thickened. Several animals were noted to be tnin. All other observations were considered incidental and unrelated to treatment. The treated skin of the died on test male was diffusely red. This taonimtarle'astmedneta.th was attributed to enteritis of unknown etiology and unrelated onsH.yPaTaersar Pathologist (1734mes) snl mE [=2(-5F 00522 BEST COPY AVAILABLE HA No. 2090576 Perso`nAnceut]e STiogxniactoulroegySheet Name dob Title Becky Beckwith Steve Beloungy Ken Bridges Pat Crary Shane E1th Shawn Frazier Steven N. Glaza Wolly Hatn Kevin Hamilton eff Hicks Calvin Horton Sharen L. Howery Gregory Johnson Paul Krebs Mayne Madison Scott McConnell Sr. Lab. Animal Asst. Lab. Antmal Asst. Sr. Lab. Antmal Asst. Sr. Lab. Animal Asst. Lab Animal Asst. Lab Animal Asst. Group Leader Adatn. Clerk Lab. Antmal Asst. Sr. Lab. Antmal Asst. Group Leader Administrative Asst. Lab. Animal Tech. Lab. Antmal Asst. Section Supervisor Lab. Animal Tech. _ Shelley McConnell "awn Conant. Ton Mavis Lab. Animal Tech. Sr. Lab. Antmal Asst. Lab. Antal Asst. Robin Olson Lab. Animal Asst. Patricia Padghem Team Leader Joseph J. Daun Lab. Animal Asst. Wichael Patzka Lab. Animal Asst. John Paulson Sr. Lab: Antmal Asst. Jane Polnow Lab. Antal Tech. Dents 8. Steiner Lab. Antmal Tech. Michael Thestng Lab. Animal Asst. Paula G. Vangen Adwinistrative Asst. Albert Olson Manpower Jim Jirschele LTE BAEeninnleeHteantleeiy,R.McTCuornnneerllSHraA.dnmpiLonaw.berACnliemrakl Asst. Slanatyre uk { Ta. [ py hho 2D T0elra igs Oodle et,Zend) halla Mull (awsuConedt ld, a A) le fhdhicie Todsdiar Quaieeb OR Nda( GR Qua, Qos nr apm & Ao Nycka\ Thisiog da ke CES 1.Lud IS7 L Mtl oliy, Initials a 8 X& Qo se Wi "so 7 "a or BY tag. Sa sme on qu 2 wT io I pZAa= COC523 REST COPY AVAILABLE waA086 rE ER ACUTE DERMAL APPLICATION LDsg IN NEW ZEALAND WHITE RABBITS TFesot sMasteretarls eix= mrs SR Bonase Lert esRET Source:meoeanmSmemssmmT--T--T: Room Nos aag line .Fpoyd 101 [bosecacao COMPOUND PREPARATION WEIGHTS. MogigutTT [vas UT sueTwp | 425 Mol Mas ows 1| one |1 T4290| 5.7 142 |sd | | #78 570 | a7| | vad| Coal asl Mos oon | | 43 |sdo | 777 1 45 | dug |544|65 1+49 | lMoottse]ooaatrs | I[ V1[d4ui| |ssivdio [|9o4o5f |gf | | dan| ! EE ICVaelrciufliaetdedby:by: -- ee EErDatee: ER #:-/,-87 CAopnpdruocvteeddbyb:y:AeJ r LDDaattee:: /-/[6-z8a7p)]| C [mie en tompeuren|lT310i3 |nsex |2[T| PwavP] eai]g CToll z aud [m2] sno [TofEEl 7 [J [a3a3 em" [To z [6w [awea lfowgpen til Sw 17edy Bn a I | J [aw CT oeml = |[ @ on0e a)aan . C[ --1 fompeslo I 1 gela a f|agna R|aguigs|OO&TwysersfroEr-BariCeu T Loo us 1z ||g lasasoai|zaaala|do2nnas | iden. xg raise: Bate jag)] on gid 20 Ce | he 2 K [a1a "ho Kized (345 Beil a| Be ao Fath Are <ommecred lee A17- SIonrtaaccted (with 8 clipper blade) NA - Not Applicable ai (00261/vmt) Reviewed 8y _C)?5] oate_IQ (0B covs2a Test mteriat:_T= 4/02. BESTCOPY AVAILABLE nowTALITY igor0 bose Vw, Ai_20289763 g-oussy [AAA AAAA NA ALAA AANA NA AA AAA ots |AAAANSALA ANANAALNA AANA AA AAA g lee AANA NIAAA AAAAAAANZA AA AANA ET 7 0%1 0 = & [esd] AA AAS AL NAANNANAANA AAA AA Fosgeldd Add LAA AAA AAAS AA A [ess fA AAS SAA NA ANNAN AANA AA AAA] [esl|AAAA AAA AAAAAAN ANA NANA AAA [oosusstAANA AAAA AAAF SANA AANNA AAAAAAA AN ANAAA NAAA N AA AN AAAAA AA A BO PP 2 2 1 PP 2PPPP 2PF 2 7 7 Po aA basesaryPo ooYlJol lb[lo Fl al le ls il Aa on el) 0-Jot eptctte. Ont Sror #5 ffs Reviews by: oh outer LOLET (021) a: 20903204 amscorions (individ) ose wet:__2.09 Ks Test mterta:_T-410a iLl Gs by PE LiA ] FeE a ber E e ] re JoEe,L esse DCIee t eeofanpaiie =[=ISrISIrS n n A ASEITE ETm|EeonL esY ydoveo O ss7 mCo nso ro-- Pr r e E m E Pe e , e =Snne Y "cR a ae ly agg |[om|pe AiE eesETo =S ESISS= EEEEEEE REEEEEEEORCSISPSS IPETOTO sawniigt faonr itmermi E2a PT teEae Eidr 4aE7or E3Ed r 4 EvE5 e E ae ao T ode 2Ti Toa ] en| ThWey IER oAel0, ra P v r----t E edi IE=EE=E=ESm S I 4 oS rIPAe E eo dEo r FF o-- fr et dmpe Ton IE IZ o E A eEeE = EeP eH E P S P E eA] A) EE dwveislenaatgensanfoirmessaeritice oA s[ e R eeen s EE1E=ErEEe e = | Tomei ST e e] mea mt F e em t Ie Z EA r e A Ee EEe PEoE sel[ h erse etee e S IE =Et EEtEEfEEE =EEa RE=EE2EE E t S4 4S PIAAIo] e TeoIgPvoOde] R 2 eEHnoiaisttksionR ot evi BF E ii e ir A[rof te o lmE t ao etir e LA atRtstEl ae Me IpAFe r e tGor] ] aal seve ona ae lL oo Pr haat Yara OPY AVAILABLE ,,, or _e0.25.21 ot mtsmZnotmy es olSecI rit 4A EEa23mrde evmoiwsen oeess emt etl er er err e Sr oesosEE-- r I b E E-- R EE--Sr Le -- ZIL E b LHme ae eerE ENE e E epeSee rE E 8eSo loss & EET Tee r mmm r= TCTTTTTETT TTPTTT TTT ET TT TT]- mmr rbRR ESR rS HEE Tr] le Ssuurbvaiivtitnegd fanoirmatles.rminal amo kB n 0p570rE [ r E E -- P mr m -- P r F A -- E EP EFe r -- e A RET -- E e E T ee-- SeI TSeT ote nt ne Pee flr ee TTTTTTPTT TTTTT] TE ------ = I --| EE and discard, E r E E Er ETr[ T E E e rE rZ rrLee E " e C E e DET Ea ae] e, ote fh (131J E-- e = ErY rrE e EEEv Ee=e= E eExists e l: ne hb E raEeeaneme r E| EST COPY AVAILABLE ACUTE DERMAL IRRITATION OBSERVATIONS HA:_10406576a Test matertal:_-4102 oose Teve:_20/k EEE Observation Per-- tod (ba I-- 2B fo | Ta 7 |Thy | 75a | Tl [[iedrevmmam T[Roomtii[ 7RNo-e. cT otad l TsT beraTtnedt||acaAntnii7 ymmeaa|RNboer.iFaF7dz0esSdo7 1rcTacAtymbrates feents ----ToToThToTfTHTHTaTo15 [[icosratracienougsnesTsTOo1T6oTToATToOT TA A1 T0 oT T&oTTaaTT6a5--1T8o] EW 1 or 20 serA Monts----T015915 ToToT5 ToTosa [Hsing 10TpToTFT 10T511112 [iEdTm TorowToTSor ToSTBo14TJ oThi a ToTa-- [[icosrstaucieonugsnesTs 9 oTpHTTaoT1o0T To oT 1o 0T TooTlaaTTOoT To a Ervine > cao sy3 aRaeayd sexeed| fpuimnet. :E7-pra loslygge upraded [ising ToTo TT <0 ToT/T T5 [Erythema 1 A) [XD n Co[stereac7TmTtoi[Tc6O5tTTaomgnTTawT|Y4ae [T M8 [Ta|TgaJotuo. [Torp]| 7~SuSbcauntacnehouisng. ehmeneorrrhage. eomay Eaeons -XB asian c Scab formation. ipo Scoats Ercaes <8 Wislgy 0- EEsxcfhoalri.ation. ReviP ewed E bey:ntJeu ar n|$0t , 4-2y 5-97 nate: R487 FP(e00r751ireom n. KGa)D 000528