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PLAINTIFF'S EXHIBIT AL-1357 511904 THE TOXICOLOGIST An Official Publication of the Society of Toxicology Abstracts of the 33rd Annual Meeting Vol. 14, No. 1, March 1994 Preface This issue of The Toxicologist is devoted to the abstracts of the presentations for the symposium, platform, poster/discussion, and poster sessions of the 33rd Annual Meeting of the Society of Toxicology, held at the Loews Anatole Hotel, Dallas, Texas, March 13-17,1994. An alphabetical Author Index, cross-referencing the corresponding abstract number(s), begins on page 439. The issue also contains a Keyword Index (by subject or chemical) to the titles of all the presentations, beginning on page 467. The abstracts are reproduced as accepted by the Program Committee of the Society of Toxicology, and appear in numerical sequence, other than the sym posia abstracts, which are collected in the front. Copies of this issue are available at $30 each plus $3 postage and handling (U.S. funds) from: Society of Toxicology 1767 Business Center Drive, Suite 302 Reston, VA 22090-5332 1994 Society of Toxicology 511904 0185 iMww^ETINOL PROTECTS AGAINST 1-NITRONAPHTHALENEINDUCED PULMONARY TOXICrTT IN MALE SPRAGUE-DAWLEY RATS J-M Sauer and 1 Q SiSS. Department of Pharmacology and Toxicology, University of Arizona. Tucson. AZ. Pretreatment of male Sprague-Oawley rats with large doses of retnol protects agansl 1-nitronaphlhalene-nduced pulmonary toxicity, limiting the amount of brcnchiolar epithelial cell necrosis and respiratory distress syndrome. The objective of this study was to further characterize the ability of retnol to protect the lung from the toxicity of 1-mtronaphthalene (1-NN) in an attempt to understand the underlying mechanisms involved. Male rats were admnistered alf-frans-retinol (75 mg/kg/d) orally lor up to one week. Twenty-four hr after the last dose of retinol, animals were given a single dose of 1-NN (50 to 250 mg/kg; i.p.). Pulmonary injury was evaluated at 6, 24, and 48 hr using bronchioalveolar lavage and morphological techniques. The most overt difference between retinol and vehicle pretreated animats, at both 24 and 40 hr after t -NN treatment, was the lack of pulmonary edema and infiltration of inflammatory cells into the lungs of retinol animals. Furthermore, retnol pretreated rats possessed only limited bronchiolar cell necrosis, restricted to the nonciliated bronchiolar epithelial cells, as compared to vehicle pretreated rats which displayed severe necrosis and exfoliation of both ciliated and nonciliated bronchiolar epithelium 24 hr following t-NN treatment. Txne- and dose-response experiments with retinol indicated that seven days of pretreatment was required to protect the lungs from the toxicity caused by 100 mgrkg of 1-NN. Moreover, the protection afforded by seven days of pretreatment was dose-dependent and could be overcome with the administration of larger amounts of 1-NN (>200 mgrkg). From these experiments, we concluded that retinol pretreatment decreased the severity of 1-NN-induced pulmonary toxicity in a dose- and time-dependent manner. Studies are underway to determine if retinol alters the disposition/metabolism of 1-NN. or induces protective mechanisms in the kmg. (Supported by NIH Grant # ES-06095) IN VITRO KINETIC ANALYSIS OF VINYL ACETATE METABOLISM IN NASAL TISSUES USING A MINI GASUPTAKE SYSTEM. M S Boedanffv. M L Taylor. D A Kr-llrr and D R Plowchalk. Haskell Laboratory for Toxicology and Industrial Medicine, EI du Pont de Nemours & Co, Newark, DE. Vinyl acetate (VA) is used in the manufacturing of polymers for the paint, adhesives and paper board industries. Chronic inhalation bioassays show that VA at high concentrations can produce nasal tumors in rats and non-neoplastic nasal lesions in mice. Several lines of evidence suggest that nasal metabolism of VA is a critical step in the mechanism of action. Development of physiological models to describe VA metabolism require metabolic rate constants that are reflective of the in vivo situation. Standard assays using homogenates frequenUy cannot be readily related to in vivo modeling. The system described here uses a single whole nasal turbinate placed in a scintillation vial containing VA vapor. Loss of VA from and the appearance of acetaldehyde (AA) into the headspace were modeled, using SimuSolv, as a one compartment description containing removal terms for VA (carboxylesterase) and AA (aldehyde dehydrogenase). Optimization of the model yielded preliminary estimates of carboxylesterase Vjj^ of 5.4 and 4.3 mg/hr for respiratory and olfactory turbinates, respectively. Km was approximately 0.01 mg/mL for both turbinates. For aldehyde dehydrogenase, Vmax was approximately 0.06 mg/hr for both turbinate types. Km could not be accurately estimated. The data are consistent with other in vivo estimates for these parameters. This technique could prove useful for estimating in vivo kinetic constants for many metabolized volatile compounds. This work was supported, in part, by the Society of the Plastics Industry. 150 THE EFFECT OF PHOSPHOLIPID MONOLAYERS ON REACTIVE GAS INTERFACIAL TRANSFER LMIacobson. A Bidani, E M Postlethwait Pulmonary Research Laboratories, University of Texas Medical Branch, Galveston. TX Pulmonary NO, uptake is mediated by reactions between NO] and surface lining layer (SLL) constituents. Solute gas formation is coupled to reaction {(Noj),, -* (NO,)--.- + RH - HNO, + R'| so that toxicity ultimately results from SLL-derived initial reaction products. Product formation depends upon both (NO]), formation and the reactive substrate profile. We have initiated studies to determine whether conditions at the pulmonary gas/liquid interface modulate (NO]), formation and. therefore, may influence local toxic responses. Pulmonary surfactant (PS) is the highly saturated phospholipid/protein complex which prevents lung collapse by reducing alveolar, surface tension (y). The influence of surfactant on NO, interfaciail transfer was investigated by transient exposure of I mM glutathione (GSH) aqueous phases +/- graded phospholip id interfacial monolayers. Interfaces were not compressed. Rate constants (k'**) for NO, gas phase disappearance were determined. Results: 1. DPPC (dipalmitoyl phosphatidylcholine) reduced y and k1*" in a (DPPC)-dependent manner. 2. PC with unsaturated fatty acids (DLPC (dilinoleoyl PC) or Egg PC) reduced y but not k'**. 3. Temperature (T) (25-*37") substantially increased It"01 for GSHalone. 4. T increased DPPC It"01 but DPPC GSH-alone. 5. DLPC and Egg PC displayed less T effect. 6. PS. isolated from bronchoalveolar lavage, functioned similar to DLPC and Egg PC. Conclusions: Since PS at the interface is highly enriched with saturated PC. alveolar NO, uptake rates may be reduced, thereby providing relative protection. Isolated PS is contaminated by nonalveolar and non-surface lipids which may confound interpretation of results. (NIH ES04952. OAR 90-23 It NIH T32ES072S4) T52 PREPARATION AND GENERATION OP SIZE-SELECTED SAMPLES OP CHRTSOTILE ASBESTOS FIBERS FOR INHALATION TOIICITT STUDIES. MA Bartsky and OB tfarhelt. DuPont Haskell Laboratory, Nevark, DE. One of the most important factors Influencing the pathogenic developaent of fiber-related lung disease is fiber dimension. Longer chrysotile fibers are considered to be aore toxic and durable than shorter fibers. Accordingly, an attempt vas made to size separate chrysotile asbestos fibers for an inhalation toxicity study comparing the effects of chrysotile asbestos vith size-separated preparations of Kevlar* aramld fibers. Canadian chrysotile asbestos fiber samples vere placed in a rotating sieve shaker and sieved through nylon mesh screens. The longer fibers vere collected and generated for inhalation studies vith a K-tron bin feeder and cyclone apparatus. Pollovlng separation and genaratlon, tha fibers vere collected on a filter and dimensional analysis (i.e., lengths and diameters) vas carried out using scanning electron microscopy techniques (vith a minimum of 300 fibers/saaple). The results shoved that the median lengths of fibers vere Increased from 3 urn in the original bulk sample to 6 urn in the generated sample preparation. Similarly, the mean lengths of fibers vere increased from 5.0 urn in the bulk sample to 9.0 urn. The diameters vere also decreased folloving separation and generation. These'data indicate that the methodology used in this study vas successful for reducing the numbers of small fibers and produced a preparation of fibers that vas suitable for comparing the effects of Kevlar* and chrysotile asbestos. 511904 0186 854 CHARACTERIZATION OF FOUR DIASTEREOMERIC BUTADIENE MONOXIDE-GUANOSINE ADDUCTS. R M Roemig and A A Elfarra. Dept, of Comparative Biosciences & Environmental Toxicol. Center. University of Wisconsin, Madison, WI. Butadiene monoxide (BM) is a major mutagenic metabolite of 1,3-butadiene, a rodent and possibly a human carcinogen. Both enantiomers of BM are formed in vitro and racemic BM has previously been shown to react in vitro with guanosine to yield two adducts that were tentatively characterized as regioisomeric guanine N-7 adducts. However, the reactivity of the separate BM enantiomers, which may determine their mutagenic and carcinogenic potency, was not determined. In this study, an attempt was made to characterize the reaction of BM and guanosine further. Four adducts were isolated by reverse-phase HPLC following the removal of the ribose moieties by acid treatment. These adducts were determined to be diastereomers formed by the nucleophilic attack of the N-7 of guanine at the two oxirane carbons of the two enantiomers of BM, based upon characterization by UV- and proton NMR spectroscopy and fast atom bombardment mass spectrometry. The finding that the four isomers were readily formed in relatively equal amounts upon the reaction of racemic BM (1.12 mmol) and guanosine (1.84 x I O'2 mmol) in phosphate buffer (pH 7.4) at 37C provides evidence for similar reactivities of the two BM enantiomers towards guanosine. (Supported by NIH grant GM 40375 and an NSF Graduate Research Fellowship) 856 ISOBOTTL WITRITS (IBS) AMD SODIUM HITRITS DEAMINATION OF DNA AT pH 3 TO 9. S S Mtrvluh. C Hinaan and S C Chan. Spplmy Inst Ras Cancar, Oniv tfab Mad Cantar* Oaaha NS. Sniffing IBN might ba involved in atiology of Kaposi's sarcoma associatad with AIDS. IBN vapor is sutaganic in Amas tast (Mirvish at al.. Bnv Molac Mutaganasls 21:247. 1993) . To saa if IBN could act by daaainating DNA basas, va raactad IBN and N&NO, with salmon tastis DNA and followed xanthina formation from guanina. DNA (0.5 ag/12 ml 0.1% aalina) was atirrad (25*0. 120 min) in closad flask attachad to pH stat with HaOB addad continuously to maintain pH. Pura IBN (97 y^mol) or N&NO, (97^801/1.62 ml 8,0) was injactad 4 x ovar 90 min. Plots of NaOK addition vs. tiaa showmd IBN took 20-30 min for hydrolysis to nitrita. DNA was pracipitatad with xtOH and radissolvad in buffar 3 x to raaova uaraactad nitrita. hydrolysad (0.35 N HC10. 100*0. 1 h) and analysad by HPLC (C-18 column alutad with 20 mM pH 2.3 K83PO4, 254 nm datactlon). Zaathlna yialds as maaa % adanlna guanina warat At pH 3. 2.47 (IBN). 2.35 (NaNO,). 0.48 (untraatad control)t at pH 4. 0.99 (IBN). 1.42 (NaNO,). 0.32 (control)1 at pH 5 and 9. all raaulta < 0.50. Raaults at pH 3 and 9 wara similar whan aulfaaata was addad aftar incubation to dastroy nitrita and solutions wara diractly hydrolyxsd and analysad. indicating no xanthina lots by dapurlaation. Similarity of IBN and nitrita raaulta and graatar affact at acidic pH suggast that IBN daamlnatas DNA via formation of nitrita and not diractly. 855 DNA DAMAGE BY CROCIDOUTE ASBESTOS IS PRIMARILY IRON DEPENDENT AND IS ENHANCED BY REDUCING AGENTS. **NK Murthy, *JE Schneider Jr. "GT Kinasewitz, *RA Flovd. *ML Maidt, *Q Pye, --KR Maples, --NF Johnson. *PB McCav. `Free Radic. Biol. Aging Res., Okla.Med.Res.Found., **Putmon. Sl Crit. Care Sect., OUHSC, Okla. City, OK and **ITRI, Albequerque, NM Oxidant induced DNA damage has been postulated to be one of the mechanisms where by asbestos fibers induce tumorigenesis. To examine this hypothesis, plasmid supercoiled DNA was incubated at 37*C with varying concentrations (8 to 250 pg/ml) of crocidolite asbestos. DNA damage was assessed by loss of supercoiled forms on agarose gel electrophoresis following 2 h and 20 h incubation. There was a consistent, fiber dose dependent DNA damage in the presence of ascorbic acid or hydrogen peroxide (HjOJ but not with asbestos alone. Whereas the system with ascorbate resulted in damage following short incubation of 2 h, that with H;Oj failed to do so despite confirmation of hydroxyl radical generation by electron spin resonance. Radical trapping agent 5,5-dimethyl-l-pyrrolineN-oxide (DMPO) was partially protective, whereas the iron chelator desferrioxamine completely prevented the DNA damage as did exclusion of oxygen. Catalase and superoxide dismutase were not protective. These results indicate that the DNA damage by asbestos is dependent on reduced iron and may involve perferrytol the firryl complex. 857 BENZAMIDE SUPPRESSION OF MALIGNANT PROGRESSION UNRELATED TO THE EXTENT OF BENZO[A]PYRENE DIOL EPOXIDE (BPDE-I) MODI FICATION OF GENOMIC DNA. D Li, I Noyes and G E Milo. Comprehensive Cancer Center, The Ohio State University, Columbus, OH. Our previous study showed that benzamide (BZ) treatment during early S phase can greatly reduce the number of carcinogen transformed human cells in culture. However, the mechanism of reduced transformation by BZ is not well established. One possibility is that BZ suppresses the formation of mutagen-DNA adducts, such as BPDE-I-dG, in the H-ras gene. To investigate this possibility, synchro nized human fibroblast cells were treated with carcinogen BPDE-I during different periods of S phase with or without 2.5 mM BZ. The DNA was digested and then irradiated by laser at 355 nm to break DNA at positions of BPDE adducts. The extent of adduct formation around Hras gene was assessed by Southern as well as high resolu tion Ligation-Mediated PCR, quantitated by densitometry. BZ treatment did not reduce overall adduct formation in this region. Our data indicate that the BZ transformation suppression is not caused by reducing the formation of site specific DNA adducts. We are currently investigating the possibility that BZ transiently alters chromatin structure, therefore, influencing DNA adduct distribution. Supported in part by NIH-NCl CA25907 (GEM). 228 511904 0187 1662 EFFECT OF FARTICLB 8I2B AND CONCENTRATION OF POCK ON ACUTE INHALATION TOXICITY OF FOLPET TECHNICAL. All iT; s Crmekamll, Lif* Scioc Rs**rcb, Ey, England; I Friadnnn; 1 Pxttxr, MOf, B*r Sbara, Isra*l; E B Gordon. 1)UkJitbia*A9B of North Aaorica, lac., Now York. To study factors affacting tha acuta toxicity of tba fungicida Folpot Technical, a series of three 4-bour nose only inhalation studlas in CO rats ware conducted with exposure concentrations ranging froa 0.79 to 4.3$ ng/L. The rats were exposed either to atmospheres containing particles with Mass Mediua Equivalent Aerodynamic Diameters (MKAD) of approximately 3 to 5ua (micronised product) or particles with MMAD of approximately 14um (non-micronised). The level of the toxic impurity perchloromethyl mercaptan (POM) was present in the two micronised samples at approximately 600 ppm or lesa than 50 ppm. Treatment and doae~related adverse effects and deaths were evident 2 hours following exposure to day 3 of the observation period. The LC50 for non-micronised material (POM - 600 ppm) was greater than 3.14 ng/L for both sexes while it decreased to 1.89 ng/L (M & P) for the micronised material with similar POM content. When POM content of micronised Folpet waa less then 50 ppm, the LC50 value increased in males to greater than 4.35 mg/L, but decreased in females to 1.08 mg/L. It is concluded that smaller particle sise Increases acute inhalation toxicity, as expeeted, but that decreasing POM has mixed results; toxicity in males was decreased but increased in females. 1664 MESOTHELIOMA INDUCTION BY SILICON CARBIDE WHISKERS AFTER INTRAPLEURAL ADMINISTRATION |N RAT. N F Johnson aod F F Hahn. Inhalation Toxicology Research Institute, Albuquerque, NM. Silicon carbide whiskers (SCW) are single crystal structures that mat have widespread use in the power generation, automotive, ^ aerospace industries. There is concern that the fine fibrous morphology of SCW may induce pulmonary disease similar to d-j, documented for asbestos exposure. Three samples of SCW and ot* sample of continuous glass filament (CGF) were injected into 4* pleural cavity of female F344/N rats to determine whether the* samples could induce mesotheliomas. Rats were also treated with crocidoiite and saline for comparative purposes. Rats injected with two of the three SCW samples (SCW $ 1 and 2) and the crocidoiite sample had significantly reduced life spans compared to the salimtreated animals. Rats treated with SCW #3 and CGF did not have t significantly reduced life span. Rats treated with SCW and crocidoiite developed mesotheliomas, while rats treated with saline or CGF did not SCW #1, 2 and 3 and crocidoiite resulted in respective tumor incidences of 90%, 87%, 23%, and S7%. These results show dut SCW can imhice mesotheliomas following intrapleural injection. TV difference in biological activity between the SCW samples could mt be explained on the basis of their physical dimension or biological activity toward cultured cells. Results from this study indicate dm SCW may be a carcinogen and should be handled with care. TV results also indicate that members of a class of fibrous materials such as SCW may possess different toxicides. Investigating one 'representative' member of a class of fibrous materials may not give results common to other class members. (Research supported by tie U.S. DOE/OHER under Contract No. DE-AC04-76EV01013.) 1663 CHANGES IN PULMONARY MARKERS OF INJURY AND DIFFERENTIAL CELL COUNTS IN RESPONSE TO RICIN AEROSOL. D M Walters, B P Bell, K A Bostian, and D A Creasia. United State* Army Medical Institute of Infectious Disease*. Frederick, MD. Ricin, a toxic lectin derived from castor beans, is lethal by systemic administration and by inhalation of aerosol. Although vaccination against ricin protects from lethality, it doe. not completely prevent pulmonary epithelial necrosis induced by inhaled ricin aerosol. It is this ricto-induced pulmonary epithelial necrosis that we are studying in greater detail. Broochoalveolar lavage (BAL) is a technique commonly used in the study of pulmonary inflammation to obtain markers of injury as well as pulmonary cells. Therefore, after exposing mice to a lethal dose of ricin aerosol (10-15 mg min/nr3), we used BAL to measure pulmonary markers of injury and to collect cells for differential cell counts. We measured lactate dehydrogenase (LDH), Kid phosptutase, 5* nucleotidase, and total protein in BAL fluid and found that LDH, 5* nucleotidase and total protein levels progressively increased in a time-related fashioo over control values. At 24 hr post ncin exposure, LDH and 5' nucleotidase levels plaieaued, while total protein continued to increase. We also found that morphologic changes, such as vacuolatioo and necrosis, in alveolar macrophages (AM) obtained from BAL were not observed until --4 hr post ricin exposure. Periodic samples of BAL (8-48 hr) showed a shift typical of an acute inflammatory response with AM decreasing from 99% to 8% and PMN increasing from I % to 92%. There was no obvious temporal correlation between acid phosphatase levels (AM activalioo/lysis) and 5* nucleotidase (leukocyte maturation) with the time of appearance of PMN in the lung. 1665 FIBER INHALATION STUDIES, LUNG BURDENS ANO BIOLOGICAL RESPONSES. J G HADLEY. E E HCC0NNE1L. N F JOHNSON. Owens-Corning Fiberglas, Granville, OH/Raleigh, NC/Inhalatlon Toxicology Research Inst., Albuquerque, NH. Recently completed fiber inhalation studies of refractory ceramic fibers in rats and hamsters have reported pulmonary fibrosis (rats and hamsters), lung tumors (rats) and mesothelioma (rats and hamsters). The airborne fiber concentration was approximately 200 f/cc, with exposures 6 hours a day, 5 days a week for either 18 or 24 months. A previous study also reported an airborne fiber concentration of about 200 f/cc with a similar exposure schedule, yet no fibrosis or lung tumors, and only a single mesothelioma in a hamster was reported. The marked difference in the pulmonary effects found in the two studies is hypothesized to be the result of effectiveness of the fiber exposure systems used in the current study. For example, the lung burden in the recent study in rats was in excess of 350,000 f/mg dry lung compared to the previous study in which only 21,000 f/mg dry lung were found. This greater than tenfold difference in lung burden between the two studies suggests that based on lung burdens, the pulmonary responses found in the two studies are consistent with the dose to the target tissue. These results indicate that the assessment of any fiber inhalation study should include careful consideration of actual lung burden of fibers as delivery systems vary greatly in their effectiveness. 420 511904 0188 may and rous that one the hese with with olite lineive a tolite r did imor ' that . The d not gical : that The such one : give y the ) A CCMPRRISOB Or TO CARCIRCCBBXC iftictb or CBRTSOTILB ABD CBOCTDOLITB ASBESTOS II BATS ATTO IHBALATIOB. EE McConnell. Raleigh, BC, TK Etrbra. Schuller lot., Denver, CO, JO Hadley. Owana-Coraing ribarglaa, Oranvllla, oa, aod A. Muaaalman, USG Intariora, Chicago, IL. Mala r!tt/ rata vara azpoaad via uoaa only inhalation to 10 MO/M1 chryaotlle (CBRT) or crocidolita (CROC) aabaatoa Tor 6 hr/da, 5 da/tvk (CERT-24 an; CROC-10 ao followed by no ezpoaure until 24 bo. Tha number of raapirabla CERT fibera (<3.0 ui D. X >5.0 uai L.) waa *101 greater than CROC! C8RI1.2 X 10*/CC; CROCal.2 X 101. Dacraaaad body weight gain and incraaaad mortality warn obaarrad with CROC up to 10 bo aftar which it waa comparable to C8RI. Both typaa of fiber* cauaad progreaaive pulmonary laaiona, i.e. nacrophagea infiltration, bronebiolization of proximal alveoli and intaratitial fibroela. Bowavar, tha laaiona ware more intana* and occurred earlier with CROC than CBRT. Plaural fibroaia waa obaarvad by 9 bo aftar CROC but not CBRT azpoaur*. Both typaa of aabaatoa fibara war* clearly carcinogenic for the rat lung canning an incraaaad incidence of broncboalvaolar adanoaaa and carcinoaua CBRTwl9% VS CROC15% compared to 2-3% unazpoaad control*). CROC alao induced a aingl* saaotbalioau. The number of fib*r*/mg dry lung aftar aahing waa greater for CBRT than CROC. Tb* raaulta of thia atndy ahow that CROC ia ar* pathogenic to tha lung* and pleura of rata than CBRT aabaatoa, even whan the azpoaur* i* ahortar and at a lower fiber burden. COMPARISONS OP THE PULMONARY EFFECTS OF SIZESEPARATED KEVLAR* ARAKID AMD CHRTSOTILB ASBESTOS FIBERS. SR Fraae, MA Hartsky, C Butterick, i DB Varheit. DuPont Haskell Laboratory, Newark, DE and Texas Tech Univ. Lubbock, TX. This multi functional study vas designed to compare the pulmonary toxic effects of inhaled, sizeseparated preparations of chrysotile asbestos fibers vith Kevlar* aramid fibrils. Rats vere exposed for 2 weeks at design fiber cones, of 750 and 400 f/cc and evaluated at several postexposure time periods. Tvo week exposures to Kevlar* aramid fibers produced a transient inflammatory response as evidenced by the results of biochemical lavage studies. Increased pulmonary cell labeling effects were measured on terminal bronchiolar surfaces immediately after exposure but vere not different from controls following a 5-day postexposure period. Similarly, a transient increase in neutrophils vas measured in the lungs of rats exposed to chrysotile asbestos fibers for tvo veeks. In contrast, hovever, substantial increases compared to controls in pulmonary cell labeling indices were measured on terminal bronchiolar, parenchymal, and subpleural surfaces immediately after, and at 5 days and 1 month postexposure. Median and mean lengths of fibers recovered from digested lung tissue vere Increased over time, suggesting that short asbestos fibers vere selectively cleared from the lungs, vith apparent insignificant pulmonary clearance of long fibers. The dimensional changes of asbestos fibers as veil as the pulmonary cell labeling data indicate that chrysotile asbestos fibers may produce greater long-term pulmonary effects vhen compared vith Kevlar* fibrils. AND II, le, inch of lave ). id as a A ar ar s, as lary d to iber For / in 1 ung ,000 than two the are sue. any eful s as heir 1667 COLLAGEN SYNTHESIS IN RAT PLEURAL MESOTHELIAL CELLS IN VITRO: DIRECT EFFECTS OF MINERAL DUSTS. TR Gelzleichter, JB Mangum, JI Everitt. Chemical Industry Institute of Toxicology, RTP, NC. Sponsor O.R. Moss. Although the production of collagen by fibroblasts in response to fibrogenic agents has been thoroughly studied, the contribution of the pleural mesothelial cell to extracellular matrix (ECM) production is poorly understood. In these experiments, we demonstrate that fibrogenic mineral dusts are capable of directly stimulating collagen synthesis by rat pleural mesothelial cells. Rat parietal pleural mesothelial cells were grown to confluence and exposed directly to 0, 1, 2.5 or 5 Hg/cm2 amosite asbestos or grunerite (non-fibrous paniculate of similar composition) for 12, 24 or 48 hours. Collagen and non-collagen protein synthesis were determined at these time- points by a 4 hour pulse with (2H)-proline. Collagen content was determined as bacterial coliagenase-soluble protein. Collagen synthesis was consistently elevated above control values for both amosite and grunerite-exposed cells at 1 and 2.5 pg/cm2 doses; however, at higher doses this response was attenuated. Maximal stimulation of collagen production was obtained at 24 hours where both amosite and grunerite produced increases in total collagen synthesis per well, ratio of collagen to non-collagen protein, and ratio of collagen to total cellular DNA. Although no clear difference in collagen production was observed between amosite and gruneriteexposed cells, amosite was consistently more cytotoxic than grunerite. as measured by mitochondrial dehydrogenase activity. We conclude that pleural mesothelial cells are capable of producing collagen in response to direct stimulation by mineral dusts. 1669 DEVELOPMENT OF A RODENT MODEL SYSTEM TO STUDY RICIN-INDUCED PULMONARY TOXICITY. D A Crea.ua. P V Lemiey, D M Walters* C Wilhelmsen. United Stales Army Medical Research Institute of Infectious Diseases, Frederick, MD. We developed an inhalation bioassay in a mouse model to study pulmooary effects of inhaled riem. At the doses used in these studies (10-15 mg min/nr> aerosol; IS pg/kg, i.v.), ricin caused pulmonary epithelial necrosis when inhaled, but ricin given i.v. did not cause any pulmonary toxicity. We found that mice vaccinated against rictn were protected from death, but not completely protected from pulmonary epithelial necrosis caused by inhaled ricin. In an attempt to further reduce the pulmonary lesion from inhaled ricin, we vaccinated mice by instilling formalin-treated ricin into the respiratory tract. Although this vaccine was successful in eliciting significant anti-ricin antibody titers in the respiratory tract, (IgA, IgG) we could not further protect the mice from inhaled ricin. To study this problem we used the intratracheal (itr) instillation model to deliver precise amounts of ricin and anti-ricin antibodies to the lung. We instilled 0.6 fig ncin with or without anti-ricin antibody. The anti-ricin antibodies used were either goal IgG or chicken IgG, pre-mixed at a 10:1 molar ratio with ncin. With the itr instillation model, we found that the toxicity and pulmonary epithelial necrosis resulting from intratncheally instilled ricin were similar to those in mice inhaling a ricin aerosol. Also, the lungs of mice receiving the ricin-antibody complex showed only minimal pulmonary epithelial necrosis, which indicated that anti-ricin antibody* when present in sufficient quantity was capable of substantially reducing the pulmonary necrosis compared to that of ricin-ooly controls. These data shows that itr instillation of ricin may be an alternative to inhalatioo of ricin and that attenuation of the pulmonary toxicity of ricin is possible. 421 511904 0189 KEY WORD INDEX 1.2, 3-TR1CHLOROPROPANE/HALOGENATED HYDROCARBONS/DNA ADDUCTS.....................................................................1283 1.3, 5-TRINITROBENZENE/SUBCHRON1C TOXICITY/FISCHER RATS.................................................................................................388 1.3- BUTADIENE/MIXTURES/STYRENE ..........................................................................................................................................................87 1.3- BUTADIENE/IMMUNOHISTOCHEMISTRY/P53 ................................................................................................................................. 520 1.3- BUTADIENE/TRANSGENIC/MUTATION .............................................................................................................................................. 942 1.1.1- TRICHLOROETHANE/DEVELOPMENTAL/NEUROTOXICITY..................................................................................................584 1,1,1 -TRICHLOROETHANE/NEUROB EHAVIORAL/TOXICOKINETICS............................................................................................. 1370 1.1- DICHLOROETHYLENE/CYTOCHROME P-450 2E 1/MOUSE.....................................................................................................1457 1.2- DIETHYL BENZENE/CROSSLINKING/NEUROFILAMENT.......................................................................................... 761 1.3- BUTADIENE/METABOLISM/BUTADIENE EPOXIDE...................................................................................................................... 1235 1.3- DICHLOROPROPENE/CANCER RISK/DRINKING WATER.............................................................................................................555 1.3- DINITROBENEZENE METABOLISM/ROUTE OF ADMINISTRATION/TESTICULAR TOXICITY ...................................265 l ,6-DINITROPYRENE/HUMAN LIVER/HEPATOCYTES, RAT, HUMAN ...............................................................................................323 1 -AMINOBEZOTRIAZOLE DERTVATTVES/METABOLIC INTERMEDIATE COMPLEX/ISOZYME-SELECTTVE..................... 108 1- NITRONAPHTHALENE/ALL-TRANS-RETINOL/CLARA CELL NECROSIS ...................................................................................149 12-O-TETRADECANOYLPHORBOL-13-ACETATE/TRANSFORMING GROWTH FACTOR-a/MACROPHAGES.....................467 19F-N. M. R7IN VITRO METABOUSM/KIDNEY PROXIMAL TUBULAR CELLS................................................................................197 19F-NMR-DETECTION/DNA ADDUCTS/DIHALOKETENES ..................................................................................................................... 373 2', 3'-DIDEOXYINOSINE/PERIPHERALNEUROPATHY/DEMYELINATION ...................................................................................... 524 2'CH3-MPTP/DIADENOSINE TETRAPHOSPHATE/PC12 CELLS .............................................................................................................1337 2.4- D/DEVELOPMENTAL TOXICITY/TOXICITY........................................................................................................................................580 2.3.7.8- TETRACHLORODEBENZO-P-DIOXIN/IMMUNOSUPPRESSION/T CELL-INDEPENDENT RESPONSE....................18 2.3.7.8- TETRACHLORODIBENZO-P-DIOXIN/EPIDERMAL GROWTH FACTOR RECEPTOR/PHOSPHOTYROSINE ... .724 2.3.7.8- TETRACHLORODIBENZO-P-DIOXIN/2,3,7,8-TETRACHLORODIBENZOFURAN/CYTOCHROME P-450 1A1 .. .1037 2.3.7.8- TETRACHLORODffiENZO-P-DIOXIN/THYMOCYTES/IN UTERO EXPOSURE............................................................1500 2,3,7, 8-TETRACHLORODIBENZO-P-DIOXIN/LIVER SLICES/CYTOCHROME P450 1A..............................................................1617 2,3,7, 8-TETRACHLORODffiENZOFURAN/CYTOCHROME P-450 1A1/2,3,7, 8-TETRACHLORODIBENZO-P-DIOXIN .1037 2,4,6-TRINITROPHENYLMETHYLNITRAMINE/MUNITION CHEMICAL/PATHOLOGY ............................................................1560 2.4- D/SOH7PERCUTANEOUS ABSORPTION ..............................................................................................................................................663 2.4- DITHIOBIURET/MEMORY/ATAXIA .......................................................................................................................................................294 2.5- HEXANEDIONE/SERTOLI CELLS/SECRETION...................................................................................................................................263 2.5- HEXANEDIONE/NEUROTOXICrrY/ION HOMEOSTASIS...............................................................................................................760 2.5- HEXANEDIONE/PYRROLE/HAIR............................................................................................................................................................1414 2.6- DI-T-BUTYL-4-NTTROPHENOL/HEPATIC/CHOLESTASIS ............................................................................................................ 681 2- ACETYLAMINOFLUORENE/UNSCHEDULED DNA SYNTHESIS/LIVER SLICES......................................................................... 29 2-ACETYLAMINOFLUORENE/IMMUNOSUPPRESSION/PROTEIN KINASE C................................................................................... 946 2-CHOLOROETHANOL/FATTY ACID HALOETHYL ESTER SYNTHASE/CONJUGATION ......................................................... 1456 2-METHOXYETHANOL/PBPK MODELING/RISK ASSESSMENT .............................................................................................................. 88 2-METHOXYETHANOL/TESTES/IN VITRO...................................................................................................................................................... 264 2-METHOXYETHANOL/THYMUS/APOPTOSIS ........................................................................................................................................... 1156 2-METHOXYETHANOL/TESTES/APOPTOSIS................................................................................................................................................1157 2-METHOXYETHANOL/THYMOCYTES/FLOWCYTOMETRY........................................................................ 1252 2-METHOXYETHANOL/NUCLEAR MAGNETIC RESONANCE SPECTROSC/METABOUSM.....................................................1289 2-METHOXYETHANOL/RAT LYMPH NODE CELLS/POLYCLONAL ANTIBODY RESPONSE...................................................1396 2-METHOXYETHANOL/CYCLOHEXIMIDE/APOPTOSIS..........................................................................................................................1424 2-METHYL-4.5-TRIMETH.-4-ISOTH.-3-ONE/SKIN SENSITIZATION/RISK ASSESSMENT........................................................... 1263 2- [14cl ACRYLONTTRITE/SPECIES DIFFERENCE/DISPOSITION.......................................................................................................1719 3`, 3'-IMINODffROPIONITRILE/NEUROTOXICrTY/p-N-METHYLAMINE-L-ALANINE................................................................ 1369 3,3', 4,4'-TETRACHLOROBIPHENYL/REPRODUCnON/FERTILIZATION ........................................................................................223 3,3'-IMINODIPROPIONITRILE/REFLEX MODIFICATION/BRAINSTEM AUDITORY EVOKED POTENTIAL ..................... 1363 3- D VISUALIZATION/TOXICOKINETICS/PB-TKMODELING..................................................................................................................84 3-H YDROXYPYRIDIN-4-ONE/BLOOD-BRAIN BARRIER/CHELATOR................................................................................................. 1000 467 511904 0190 3- MERCAPTOPRYUVATE/CYANIDE/THIOCYANATE............................................................................................................................822 32P-POSTLABELING/DNA ADDUCTS/HUMAN BIOMONITORING......................................................................................................14l7 32P-POSTLABELLING/HUMAN LIVER/TAMOXIFEN.................................................................................................................................1602 4- AMINOBIPHENYL/BENZlDlNE/CARCINOGEN POTENCY................................................................................................................ 47] 4-AMINOBIPHENYL/SMOKERS/HEMOGLOB IN ......................................................................................................................................... I47j 4-HYDROXYNONENAL/ALDEHYDE DEHYDROGENASE/COVALENT ............................................................................................1699 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE/INBORN ERROR OF METABOLISM/TYROSINAEMIA ......................... 826 4-METHYLHEPTANE/URINARYMETABOLITES/METABOLISM.......................................................................................................... 129] 4-METHYLPYRAZOLE/PROTEIN KINASE C/PEROXISOME PROLIFERATORS ............................................................................. 1165 4-NITROQUINOLINE-N-OXIDE/SUPEROXIDE/ESR.......................................................................................................................................633 4-PHENYLCYCLOHEXENE/INHALATION/NEUROTOXICITY...............................................................................................................1237 4-VINYL-1 -CYCLOHEXENE DIEPOXIDE/GLUTATHIONE/REPRODUCTION ................................................................................... 656 4-VINYLCYCLOHEXENE/OVOTOXICITY/REACnVE EPOXIDES.......................................................................................................... 212 4-VINYLCYCLOHEXENE/OVARIANTOXICrrY/TERATOGENICrrY ...................................................................................................586 4- VINYLCYCLOHEXENE/METABOLISM/SPECIES DIFFERENCES................................................................................................. 1312 5,8,11,14-EICOSATETRAYNOIC ACID/PEROXIDASES/TRANSPLACENTAL................................................................................... 588 5- AMINOLEVULINATE/ASCORBIC ACID/UROPORPHYRIN .............................................................................................................1103 6- HYDROXYDOPAMINE/ASTROCYTES/METHAMPHETAMINE...................................................................................................... 1345 7,12-DIMETHYLBENZ[A]ANTHRACENE/DIELDRIN/DISPOSmON..................................................................................................... 710 7H-DIBENZO(C,GX^ARBAZOLE/32P-POSTLABELING/DNA ADDUCTS ............................................................................................ 1284 8-HYDROXYDEOXYGUANOSINE/HALOACETATES/UVER .................................................................................................................1465 8-HYDROXYQUINOLINE/GLUTATHIONE/QUINOLINE ..............................................................................................................................702 8- OXOGUANINE/CHELATORS/HEAVY METALS ..................................................................................................................................... 999 9- ANTHRONES/PROTEIN KINASE CmJMOR PROMOTION................................................................................................................ 676 95% O2/ELLAGIC ACID/COCAINE ......................................................................................................................................................................592 p-AMINOPHENOL/NEPHROTOXICITY/GLUTATHIONE ............................................................................................................................181 p-AMINOPHENOL/HEPATOTOXICrrY/GLUTATHIONE............................................................................................................................1442 a-METHYLDOPAMINE/GLUTATHIONE/NEUROTOXICITY.................................................................................................................... 654 3-N-METHYLAMINE-L-ALANINE/3',3'-IMINODIPROPIONITRILE/NEUROTOXICITY................................................................1369 (3-NAPHTHOFLAVONE/ALIESTERASES/ORGANOPHOSPHATES......................................................................................................... 915 b-GUANIDINOPROPIONIC ACED/METHODS/TISSUE CREATINE..........................................................................................................1570 b-LYASE/BIOTRANSFORMATION/DCVC........................................................................................................................................................ 196 IN VITRO KINETICS/NASAL/CARBOXYLESTERASE ............................................................................................. 151 HPRT MUTATION/GLUTATHIONE TRANSFERASE/BENZENE ............................................................................................................ 1278 32P-POSTLABEUNG/DNA ADDUCTS/7H-DEBENZO(C,G)CARBAZOLE ............................................................................................ 1284 3H-PHORBOL ESTER BINDING/POLYCHLORINATED BIPHENYLS/STRUCTURE-ACTTVTTY.................................................. 1352 A-ESTERASE/ORGANOPHOSPHATE HYDROLYSIS/PARAOXON........................................................................................................1297 A-NAPATHYLISOTHIOCYANATE/LEUKOTRIENES/LrVER...................................................................................................................1440 A-NAPTHLISOTHIOCYANATE/LIVER/PLATELETS.................................................................................................................................. 1437 A549/GLUTATHIONE/CYSTEINE ........................................................................................................................................................................643 ABSORBED DOSE/SKIN RESERVOIR/BIOAVAILABILITY.......................................................................................................................662 ABSORPTION/ARSENICALS/SKIN..................................................................................................................................................................... 355 ABSORPTION/SWINE/LEAD...................................................................................................................................................................................395 ABSORPTION/SWINE/LEAD...................................................................................................................................................................................396 ABSORPTION/LEAD/PHARMACOKINETIC MODELS................................................................................................................................. 562 ABSORPTION/CARBARYL/SKIN..........................................................................................................................................................................664 ACCELERATION/ENVIRONMENTAL TOBACCO SMOKE/ARTERIOSCLEROSIS............................................................................ 722 ACCELERATOR MASS SPECTROMETRY/LOW-DOSE PHARACOKINETTCS/DNA ADDUCT DOSIMETRY ...........................11 ACCELERATOR MASS SPECTROMETRY/BIODOSIMETRY/BENZENE ............................................................................................ 1703 ACCUMULATION/CH3HG+-RESISTANT CELL LINE/GLUTATHIONE ................................................................................................ 994 ACETALDEHYDE/NASAL CAVITY/VAPOR UPTAKE................................................................................................................................ 119* ACETAMIDE/CANCER/RISK .................................................................................................................................................................................541 ACETAMINOPHEN/IMMUNOSUPPRESSION/IN VITRO............................................................................................................................... 22 ACETAMINOPHEN/HEPATOTOXICITY/LIVER SLICES............................................................................................................................... 31 ACETAMINOPHEN/DTPVACCINE/BIOACTIVATION ................................................................................................................................. 95 ACET/ acet/ acet/ ACET/ ACET/ aceta aceta ACETA ACETA ACETA ACETA aceta aceta; ACETA] ACETA! ACETA! ACETA! ACETA! ACETOb ACETYC ACETYL ACETYL ACETYL ACETYL ACETYL ACETYL ACETYL ACETYLi ACETYLi ACETYLi ACETYLi ACETYLI ACETYLI ACETYLI ACEDOSI! ACIV1CIN ACOUSTT ACROLE ACROLE ACROLE: ACROLE1 ACROLEI ACRYLA. ACRYLA! ACRYLAN ACRYLAN ACRYLAN ACRYLAlv ACRYLAV ACRYLAM ACRYLAM ACRYLAM ACRYLAT1 ACRYLIC / ACRYLIC / 468 511904 0191 ACETAMINOPHEN/BIOTRANSFORMATION/CYTOCHROME P-450 ........................................................................................................96 ACETAMINOPHEN/CYTOCHROMEP-450/FLUVOXAMINE ......................................................................................................................130 acetaminophen/nephrotoxicity/in vivo covalent BINDING............................................................................................. 195 ACETAMINOPHEN/CATARACtOGENESIS/AH RECEPTOR ..................................................................................................................... 374 ACETAMINOPHEN/DNA DAMAGE/PROLIFERATION................................................................................................................................ 430 ACETAMINOPHEN/OXIDANTSTRESS/DIQUAT........................................................................................................................................... 607 ACETAMINOPHEN/CATS/HEINZ BODY ........................................................................................................................................................... 809 ACETAMINOPHEN/CYTOPROTECTION/APOPTOSIS.................................................................................................................................1155 ACETAMINOPHEN/HEPATOCYTES/DNA REPAIR INHIBITORS .......................................................................................................... 1285 ACETAMINOPHEN/HEPATOTOXICITY/ANTIGENIC BIOMARKER ....................................................................................................1408 ACETAMINOPHEN/COVALENTBINDING/HEPATOTOXICTY............................................................................................................... 1686 ACETAMINOPHEN/COVALENT BINDING/HEPATOTOXICITY .............................................................................................................1687 ACETAMINOPHEN/COVALENT BINDING/HEPATOTOXICITY.............................................................................................................1688 ACETAMINOPHEN/NEPHROTOXICITY/CYP2El......................................................................................................................................... 1689 ACETAMINOPHEN/HEPATOTOXICITY/GLUTATHIONE.......................................................................................................................... 1690 ACETAMINOPHEN/COVALENTBINDING/HEPATOTOXICITY.............................................................................................................1692 ACETAMINOPHEN/COVALENTBINDING/HEPATOTOXICITY.............................................................................................................1693 ACETAMINOPHENiCOVALENT BINDING/NUCLEO TRANSLOCATION OF ADDUCTS/LAMIN a......................................... 1691 ACETONE/RISK ASSESSMENT/POTABLE WATER.......................................................................................................................................554 acetycholinesterase/in UTERO EXPOSURE/CHLORPYRIFOS................................................................................................... 910 ACETYLAMINOFLUORENE/HEPATOCARCINOGENESIS/BIOTRANSFORMATION...................................................................... 848 ACETYLCHOLINESTERASE/NEUROPATHY TARGET ESTERASE/SH-SY5Y HUMAN NEUROBLASTOMA CELLS......... 318 ACETYLCHOLINESTERASE/SKIN PENETRATION/TOPICAL SKIN PROTECTANT.........................................................................341 ACETYLCHOLINESTERASE/IMMUNOTOXICOLOGY/ORGANOPHOSPHATES............................................................................... 414 ACETYLCHOLINESTERASE/INHIBmON/REACnVATION..................................................................................................................... 904 ACETYLCHOLINESTERASE/NEUROTOXIC ESTERASE/ISOMALATHION ........................................................................................ 911 ACETYLCHOLINESTERASE/PARAOXON/TOLERANCE............................................................................................................................913 ACETYLCHOLINESTERASE/PARAOXON/TOLERANCE........................................................................................................................... 914 ACETYLCHOLINESTERASE/ORGANOPHOSPHATES/MUSCARINICRECEPTORS ........................................................................ 919 ACETYLCHOLINESTERASE/PARAOXON/FISH........................................................................................................................................... 1519 ACETYLCHOUNESTERASE/ERYTHROCYTE/SENSmVITY...................... *....................................................................................... 1564 ACETYLCHOLINESTERASE ACTIVITY/PESTICIDE MIXTURES/SYSY CELL LINE...................................................................... 1353 ACETYLCHOLINESTERASE INHmiTION/CHLORPYRIFOS-OXON/ORGANOPHOSPHATE INHIBITION..............................909 ACETYLCHOLINESTERASE INHIBmON/ORGANOPHOSPHATES/HEPATIC ALIESTERASES................................................ 1533 ACIDOSIS/CALCIUM/CYANIDE ........................................................................................................................................................................ 1491 ! ACIV1CIN/Y-GLUTAMYLTRANSPEPTIDASE/NRK-49FCELL...................................................................................................................640 ACOUSTIC STARTLE/BEHAVIOR/RATS...........................................................................................................................................................301 ACROLEIN/PULMONARY ENDOTHELIUM/GLUTATHIONE ADDUCT ...............................................................................................307 ACROLEIN/MERCAPTURIC ACIDS/CYCLOPHOSPHAMIDE..................................................................................................................... 370 ACROLEIN/ALDEHYDES/PROTEIN KINASE C ............................................................................................................................................. 464 ACROLEIN/AEROSOL PARTICLE/PULMONARY TOXICITY .................................................................................................................1196 ACROLEIN MERCAPTURIC ACIDS/CYCLOPHOSPHAMIDE/HEMORRHAGIC CYSTITIS............................................................. 369 ACRYLAMIDE/GLUTATHIONE/DOMINANTLETHAL................................................................................................................................ 202 j ACRYLAMIDE/GLUTATHIONE/SPERM............................................................................................................................................................. 203 ! ACRYLAMIDE/TOXICOKINETICS/CHICKENS............................................................................................................................................... 385 j ACRYLAMIDE/PERIPHERAL NEUROPATHY/GAP-43 ................................................................................................................................451 ACRYLAMIDE/KINESIN/AXONAL TRANSPORT........................................................................................................................................... 766 j ACRYLAMIDE/PHOSPHORYLATION/MICROTUBULES/CYTOSKELETON........................................................................................767 ACRYLAMIDE/PC 12/NGF........................................................................................................................................................................................768 | ACRYLAMIDE/GROWTH CONE/MORPHOLOGY ..................................................................................................................................... ..769 i ACRYLAMIDE/GROWTH FACTORS/IN VITRO TESTING ........................................................................................................................1360 ' ACRYLAMEDE/EXTRAPOLATION/RISK ASSESSMENT............................................................................................................................ 1586 ACRYLATES/IN-VITRO/GLUTATHIONE...........................................................................................................................................................659 ACRYLIC ACID/NASAL TOXICITY/OLFACTORY TOXICITY................................................................................................................. 1212 ACRYLIC ACID/TOXICOKINETICS/DISPOSmON ..................................................................................................................................... 1704 469 ACRYLIC ACID/TOXICOKINEnCS/DISPOSrnON ACRYLONITRILE/CYANOETHYLENE OXIDE/PHARMACOKINEnCS.............................................. ACRYLONTTRILE/BIOLOGIC MARKERS/COVALENT BINDING........................................................ ACRYLONTTRILE/TROUT/PERSISTANCE (T 1/2)................................................................................... ACTIVE OXYGEN/SELENTTE/GLUTATHIONE....................................................................................... ACTIVE OXYGEN/DNA STRAND BREAKS/SELENIUM....................................................................... ACUTE/PETROLEUM/MICE...................................................................................................................... ACUTE/MUTAGENICITY/REPELLENT .................................................................................................. ACUTE/ALIPHATIC AMINES/INHALATION........................................................................................... ACUTE/INHALATION/LIQUID AEROSOLS............................................................................................. ACUTE INHALATION/SULFURYL FLOURIDE/EVOKED POTENTIALS ............................................. ACUTE PHASE/DIMETHYLNITROSAMINE/CHRONIC......................................................................... ACUTE PHASE PROTEINS/LPS (ENDOTOXIN)/HEPATOCYTES.......................................................... ACUTE TOXICITY/PULMONARY INFLAMMATION/SILICA................................................................ ACUTE TOXICITY/IRRITANCY/GLUTARALDEHYDE......................................................................... ACUTE TOXICITY/DIAGNOSTIC IMAGING/GADOLINIUM ................................................................ ACYL GLUCURONIDE/HEPATOTOXICTTY/REACTTVE-METABOLTTE ............................................. ACYL-COA BINDING PROTEIN/FATTY ACID-BINDING PROTEIN/PERFLUORODECANOIC ACID ADAPTION/INHALATION/HEXAMETHYLENE DUSOCYANATE........................................................ ADDUCT TURNOVER/HALOTHANE/HEPATOTOXiaTY.................................................................... ADDUCTS/HEMGLOBIN/DINrTROBENZENE..................... ................................................................ ADDUCTS/HEMOGLOBIN/ETHYL CARBAMATE................................................................................. ADDUCTS/STRESS PROTEINS/MITOCHONDRIA ................................................................................. ADDUCTS/AMINO ACIDS/CHROMIUM.................................................................................................. ADDUCTS/TOLUENE DnSOCYANATE/SENSITIZATION..................................................................... ADDUCTS/URINARY METABOLITES/BENZO(A)PYRENE .................................................................. ADDUCTS/ANTIBODIES/BROMOBENZENE........................................................................................... ADHESION MOLECULES/SILICA/NEUTROPHILS................................................................................. ADIPOSE TISSUE/GLUCOSE TRANSPORT/TCDD................................................................................. ADITOPRIM/ANEMWTHROMBOCYTOPENIA..................................................................................... ADJUVANCY/HYPERSENSmVITY/SILICONES ................................................................................... ADJUVANTS/ALUMINUM/GP120............................................................................................................ ADRENALECTOMIZED/IMMUNE SYSTEM/ETHANOL ....................................................................... ADRENERGIC/CELL PROLIFERATION/LABELLING INDEX .............................................................. ADRENERGIC AGONIST/BODY MASS/BODY COMPOSITION............................................................ ADRENERGIC ANTAGONISTS/BROMOBENZENE/HEPATOTOXKTTY............................................. ADVERSE EFFECTS/PESTICIDES/REGULATORY................................................................................. AEROSOL/CANINE EXPOSURE/INHALATION TOXICOLOGY............................................................ AEROSOUSENSORY IRRITATION/TRIETHYLENE GLYCOL.............................................................. AEROSOL PARTICLE/PULMONARY TOXICITY/ACROLEIN .............................................................. AET AND LIVER INJURY/UVER NECROSIS, PREVENTION/CARBON TETRACHLORIDE ............ AFLATOXIN/LIVER SLICES/FUMONISIN............................................................................................... AFLATOXIN/METABOLiSM/HSCAS OR CLAY ..................................................................................... AFLATOXIN B 1/GLUTATHIONE S-TRANSFERASE YC2/INDOLE-3-CARBINOL ............................. AFLATOXIN Bt/BETA-NAPHTHOFLAVONE/INDOLE-3-CARBINOL.................................................. AFLATOXIN B i/COUMARIN/ANTIMUTAGEN....................................................................................... AFLATOXIN B i/CELL CYCLE ANALYSIS/DIETARY RESTRICTION.................................................. AFLATOXIN B|/METABOLISM/ZEBRAFISH......................................................................................... AFLATOXIN Bi/BIOTRANSFORMATION/CHANNEL CATFISH.......................................................... AFLATOXIN Bi/LIPOXYGENASE/HUMAN PLACENTA....................................................................... AFLATOXIN B i/CHICKEN/CYTOCHROME P-450 ................................................................................. AFLATOXIN Bi/BIOACTIVATION/HUMAN LUNG ............................................................................... AGE/HYPEROXIA/OXYGEN RADICALS................................................................................................. AGE-RELATED CHANGES/METHAMPHETAMINE NEUROTOXICITY/DOPAMINE/GFAP.............. AGGREGATION INHIBITORS/ANTIPLATELET/NIPECOTAMIDES .................................................... V1705 P ?n *406 *713 100? 1009 -687 92) 1214 166| 137) 955 683 277 672 1136 .1192 .1416 .1700 ..241 .1035 .1550 ...20 ..534 .1397 ..434 ..808 ..699 ..795 ..158 .1207 .1196 .1049 ..773 ..777 ...43 ...42 ...48 ..200 ..686 .1287 .1292 .1301 .1305 .601 .1333 .1553 ag AG ag ag ag AH ah ah AH AH AH AH AH AH AH AH AH AH AH AH AH AH AH AH AH AH AIF AH AH AH AH AIF AL AL AL' AL AL AL AL AL AL AL AL AL AL AL AL AL AL AL AL AL AL AL 470 511904 01q3 170S 76 1406 1713 1008 1009 687 923 214 661 373 955 683 277 .672 023 715 1099 1589 1683 .321 .387 1136 1192 1409 1416 1700 .241 1035 1550 . .20 .534 .1397 . .434 . .808 . .699 .795 .158 1207 1196 1049 . .773 ...777 ... .43 ... .42 ... .48 ...200 ...686 . .1287 . .1292 . .1301 ..1305 . .601 .1333 .1553 aging/glutathione/macular degeneration AGING/TCDD/PHARMACOKINETICS aging/cell PROLIFERATION/OZONE................................................. AGING/BRONCHO-ALVEOLAR LAVAGE/OZONE ............................. agonist affinity/ah RECEPTOR/GENETIC polymorphism AGONISTS/SCREEN/AH RECEPTOR.......................................................... AH LOCUS/DNa ADDUCTS/PREGNANCY .....................................................................................................................................................1281 AH RECEPTOR/ESTROGEN RECEPTOR/CROSS TALK.................................................................................................................................112 AH RECEPTOR/ARNT/TCDD ................................................................................................................................................................................. 234 AH RECEPTOR/ACETAMINOPHEN/CATARACTOGENESIS ..................................................................................................................... 374 AH RECEPTOR/ANTIESTROGEN/CANCER...................................................................................................................................................... 732 AH RECEPTOR/GENE EXPRESSION/TCDD.....................................................................................................................................................1024 AH RECEPTOR/IMMUNOASSAY/TCDD ......................................................................................................................................................... 1025 AH RECEPTOR/DNA BINDING/TCDD ..............................................................................................................................................................1026 AH RECEPTOR/TCDD/EMBRYONIC.................................................................................................................................................................. 1028 AH RECEPTOR/GENETIC POLYMORPHISM/AGONIST AFFINITY ......................................................................................................1030 AH RECEPTOR/TCDD/CHROMOSOME 7......................................................................................................................................................... 1031 AHRECEPTOR/TCDD/EXPRESSION.................................................................................................................................................................. 1032 AHRECEPTOR/TCDD/BENZO[A]PYRENE .................................. 1034 AH RECEPTOR/CYP1A l/NEROTOXICITY.......................................................................................................................................................1341 AHRECEPTOR/PROTEOLYSIS/TCDD ............................................ 1518 AH RECEPTOR/AGONISTS/SCREEN.................................................................................................................................................................. 1614 AH RECEPTOR/TCDD/CYTOCHROME P-450 ................................................................................................................................................ 1616 AH RECEPTOR/TCDD/CLONING......................................................................................................................................................................... 1620 AH-RECEPTOR/ARNT/DIOXIN ........................................................................................................................................................................... 1033 AIDS/THYROED/N-BUTYL-l-DEOXYNOJIRMYCIN .....................................................................................................................................530 AIDS/MITOCHONDRIA/MUTAGENESIS ...........................................................................................................................................................531 AIR STANDARDS/TOXICOKINEnCS/HYDROGEN SULFIDE.................................................................................................................. 794 AIRBORNE (OR ATMOSPHERIC)/POLYCHLORINATED BIPHENYLS/PLANARIA.........................................................................1060 AIRWAY INFLAMMATION/ENDOTOXIN/CYTOKINES............................................................................................................................. 271 AIRWAY SMOOTH MUSCLE/FORMALDEHYDE/AIRWAYS.....................................................................................................................965 AIRWAYS/LUNG/GLUTATHIONE........................................................................................................................................................................ 649 AIRWAYS/AIRWAY SMOOTH MUSCLE/FORMALDEHYDE.....................................................................................................................965 ALA SYNTHETASE MRNA/MERCURY/KIDNEY......................................................................................................................................... 1186 ALBUMIN/ESTROGEN/TUMOR............................................................................................................................................................................ 454 ALCOHOL/LIVER TRANSPLANTATION/RADICALS .................................................................................................................................. 628 ALCOHOL/TOXICITY/URETHANE......................................................................................................................................................................789 ALCOHOL/PORPHYRIA/HEXACHLOROBENZENE.....................................................................................................................................1071 ALCOHOL/ETHANOL/CYP2E1............................................................................................................................................................................. 1295 ALCOHOL/KUPFFER CELLS/HYPOXIA........................................................................................................................................................... 1450 ALCOHOL/KUPFFER CELLS/OXYGEN CONSUMPTION ..........................................................................................................................1453 ALCOHOL DEHYDROGENASE/ETHANOL/P-NTTROSOPHENOL............................................................................................................690 ALCOHOL DEHYDROGENASE/HUMAN ISOZYMES/P-NITROSOPHENOL ...................................................................................... 1306 ALDEHYDE DEHYDROGENASE/TRANSCRIPTION FACTOR-BINDING SITES/[AH] GENE BATTERY.................................1621 ALDEHYDE DEHYDROGENASE/COVALENT/4-HYDROXYNONENAL .............................................................................................1699 ALDEHYDE DEHYDROGENASE GENE/TRANSCRIPTION FACTOR-BINDING SITES/[AH] GENE BATTERY ................... 1623 ALDEHYDES/PROTEIN KINASE C/ACROLEIN ............................................................................................................................................. 464 ALDEHYDES/STRUCTURE-ACTTVITY RELATIONSHIP/GLUTATHIONE............................................................................................ 658 ALDEHYDES/MIXTURES/NASALTOXICITY................................................................................................................................................ 1195 ALDOSE REDUCTASE INH1BITOR/PRIMATE/CT P-450 ................................................................................................................................91 ALDOSE REDUCTASE INHIBITORS/BIOTRANSFORMATION/OCULAR ...........................................................................................1313 ALIESTERASES/ORGANOPHOSPHATES/p-NAPHTHOFLAVONE ..........................................................................................................915 ALIPHATIC AMINES/INHALATION/ACUTE.................................................................................................................................................. 1214 ALKALINE ELimON/CARCINOGEN/DNA STRAND BREAKS................................................................................................................ 840 ALKALINE PHOSPHATASE/TYPE H CELLS/PULMONARY INJURY......................................................................................................148 471 511904 0194 ALKOXYRESORUFIN ETHERS/PLANTS/CYTOCHROME P-450 ..................................................................... ALKOXYSILANES/lNH.AIiATTON/STRUCTURE ACTIVITY RELATIONSHIPS........................................... ALKYLATING AGENT/PRIMARY RENAL CELL CULTURE/OXIDATIVE INJURY.................................. ALKYLATION/CLONE/DNA REPAIR ......................................................................................................................... ALKYLAnON/LAMININ/SULFUR MUSTARD....................................................................................................... ALKYLPHENOUPROTEIN SYNTHESIS/LUNG SLICES ..................................................................................... ALKYLPHENOIVHEPATOTOXICTTY/QUINONE METHIDE.............................................................................. ALL-TRANS-RETINOL/CLARA CELLNECROSIS/l-NITRONAPHTHALENE ............................................. ALLERGY/MODELS/PROTEINS.................................................................................................................................... ALLERGY/CYTOKINES/IN VITRO ............................................................................................................................. ALLIGATOR/PHEONOBARBITAL/CYTOCHROME P-450................................................................................... ALLYL ALCOHOL/CRYOPRESERVATION/HEPATOCYTES ............................................................................ ALLYL ALCOHOL/ATP/ENERGY CHARGE ........................................................................................................... ALLYL ALCOHOL/CAFFEINE/HEPATOCYTES ..................................................................................................... ALLYLNITRILE/CYANIDE/METABOLISM............................................................................................................. ALPHA 2U-GLOBUUN/KIDNEY LESIONS/DEET.................................................................................................. ALPHA-2-MICROGLOB ULEN/KIDNEY/URINARY BLADDER.......................................................................... ALPHA-ACED GLYCOPROTEIN/GENE EXPRESSION/MERCURY................................................................... ALPHA-NAPHTHYLISOTHIOCYANATE/LTVER/GLUTATHIONE................................................................... ALPHA2U-GLOBULIN/GLYCOSAMINOGLYCAN/KIDNEY.............................................................................. ALTERED ENZYME PHENOTYPE/HEPATOCARCINOGENESIS/PROGRESSION .................................... ALUMINUM/LONG-TERM POTENTIATION/GLUTAMATE RELEASE.......................................................... ALUMINUM/GP120/ADJUVANTS ............................................................................................................................... ALUMINUM/HEPATOCYTES/CELL KILLING......................................................................................................... ALUMINUM/PHOSPHOLIPASE C/PHOSPHATIDYLINOSITOL ........................................................................ ALUMINUM/CALCIUM/GILLS...................................................................................................................................... ALVEOLAR MACROPHAGES/TUMOR NECROSIS FACTOR-ALPHA/PHOSGENE .................................. AMES ASSAY/MUTAGENICITY/GENOTOXICITY................................................................................................ AMESASSAY/MUTATOX/SEDIMENT...................................................................................................................... AMILORIDE/CYSTIC FIBROSIS/INHALATION...................................................................................................... AMINE OXIDASE/AORTA/ELASTIN........................................................................................................................... AMINO ACID TRANSPORT/FANCONI SYNDROME/MALEIC ACID ............................................................ AMINO ACID TRANSPORT SYSTEM L/METHYLMERCURY/BLOOD-BRAIN BARRIER....................... AMINO ACIDS/CHROMIUM/ADDUCTS.................................................................................................................... AMINO ISOBUTYRIC ACID .......................................................................................................................................... AMIODARONE/PULMONARY INFLAMMATION/PULMONARY FIBROSIS............................................... AMNESIAC SHELLFISH POISONING/GLUTAMATE/DOMOIC ACID............................................................ AMOSITE ASBESTOS/MESOTHELIAL CELL/COLLAGEN................................................................................ AMPHIPHILIC DRUGS/NITRIC OXIDE/INHIBmON............................................................................................ AMPHOCILTM/DEVELOPMENTAL TOXICITY/LIPID COMPLEX..................................................................... AMYOTROPHIC LATERAL SCLEROSIS/INSULIN-LIKE GROWTH FACTOR/PHARMACOKINETICS AMYOTROPHIC LATERAL SCLEROSIS/INSULIN-LIKE GROWTH FACTOR/SAFETY ......................... ANABOLIC-ANDROGENIC STEROIDS/LIVER CELL CULTURE/GSH.......................................................... ANABOLIC-ANDROGENIC STEROIDS/INTRACELLULAR CALCIUM/HEART CELL CULTURES ... ANALOGUES/PEROXISOMES/CIPROFIBRATE.................................................................................................... ANALYSIS/LIPID PEROXIDATION/GAS CHROMATOGRAPHY..................................................................... ANALYSIS/AUTOMATED/METHEMOGLOBIN .................................................................................................... ANDROGEN PRODUCTION/TCDD/MALE REPRODUCTIVE SYSTEM.......................................................... ANEMIA/LEAD/ERYTHROPOIETIN........................................................................................................................... ANEMIA/METHEMOGLOBIN/HEINZ BODY........................................................................................................... ANEMIA/THROMBOCYTOPENIA/ADITOPRIM.................................................................................................... ANEMIA/INHALATION/ARSINE................................................................................................................................. ANESTHESIA/BISULFITE/NERVE............................................................................................................................... ANESTHETICS/HEPATOTOXICITY/HALOGENATED HYDROCARBONS.................................................... ANEUPLOIDY/FLUORESCENCE IN SITU HYBRIDIZATION/CHROMOSOME PAINTING.................... '22 1215 ..605 859 -1694 27 363 -149 1256 1613 97 1088 1447 1454 1296 -.175 171 -.995 .1438 ..816 ..964 . .506 ..534 .1182 .1366 .1655 ..752 .1273 .1634 ..830 .1481 ..191 .1184 .1192 ..802 ..272 ..564 .1667 ..736 ..573 ..377 ..378 ..692 .1474 .1097 ..629 .1572 .1501 ..897 .1548 .1550 .1590 .1348 .1462 ....8 AN! AN an an, ani an an an< AN AN AN AN AN an an AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN AN ANT AN AN AN AN AN ANX AOR AP-I APL APO APO APO 472 511904 0195 I $03 ^IMAL MODEL/CARCINOGENESIS/ESTROGEN ....................................................................................................................................... 459 jjsTIMAL REDUCTION/STAGEWISE DESIGN/STATISTICAL DESIGN................................................................................................... 567 ^vMIMAL RESTRAINT/INHALATION/NOSE ONLY EXPOSURE/CORE BODY TEMPERATURE.......................................... .866 j^NlMAL-MODEL/PROMOTION/CIGARETTE-SMOKE-CONDENSATE................................................................................................. 462 ^NION/CALCIUM/LEAD...........................................................................................................................................................................................903 ^NOXLA/MITOCHONDRIA/CALCIUM..............................................................................................................................................................1495 ^NQ-3598/TOXICOKINETICS/BIOTRANSFORMATION.............................................................................................................................. 375 j ^NTAGONISM/CARRIER ERYTHROCYTES/PAROXON ..........................................................................................................................1537 I xNTI-HIV/PLACENTA/DIDEOXYINOSINE.......................................................................................................................................................525 j ^^NTI-HIV/TOXICITY/PLACENTA.........................................................................................................................................................................526 1 xNTI-PLATELET/IIB/IIIA INHIBITOR/ANTICOAGULANT........................................................................................................................1489 j AKTIARRHYTHMIC/BRB-I-28/BIOTRANSFORMATION ............................................................................................................................807 i ANTIBODIES/PEPTIDE/CYTOCHROME P-450 .................................................................................................................................................. 92 ; ^TmODffiS/CALCIUM/BERYLLIUM..............................................................................................................................................................1012 | ANTIBODIES/EUSA/GUINEAPIG.......................................................................................................................................................................1609 ! aNTIBODIES/BROMOBENZENE/ADDUCTS.................................................................................................................................................. 1700 ! aNTTBODY/HALOTHANE/CROSSREACTTVITY ......................................................................................................................................... 1608 anticancer agents/mYELOTOXICITY/HEPATOTOXICITY.......................................................................................................... 1105 ANTICARCINOGENIC/LIVER/CADMIUM...........................................................................................................................................................38 ANTICHOLINESTERASE/BIOACTTVATION/IN VITRO................................................................................................................................905 ANTICOAGULANT/ANTI-PLATELET/nB/IHAINHIBITOR........................ 1489 ANTIDOTES/SULFIDBTOXICITY........................................................................................................................................................................ 823 ANTIESTROGEN/ER/SP1 INTERACTION/TRANSCRIPTION ....................................................................................................................... 47 ANTIESTROGEN/TCDD/VITELLOGENIN ........................................................................................................................................................ 450 ANTIESTROGEN/CANCER/AH RECEPTOR...................................................................................................................................................... 732 ANTIESTROGENICITY/CHLORINATEDAZO(XY)BENZENES/TCDD ................................................................................................. 1507 ANTIFIBROGENIC/ANTICIRRHOTIC/LIPOCYTE/SCREEN....................................................................................................................... 313 ANTIGEN PRESENTATION/HUMAN/LANGERHANS CELLS .................................................................................................................1604 ANTIGENIC BIOMARKER/ACETAMINOPHEN/HEPATOTOXICITY ................................................................................................... 1408 i ANTIHYPOTENSIVE DRUG/NO SYNTHASE INHIBITOR/NG-METHYL-L-ARGININE................................................................... 803 1 ANTIINFLAMMATORY/CNS/CONVULSIONS ............................................................................................................................................... 810 ANTILEISHMANIAL/HEMOLYSIS/HEPATOTOXICrrY............................................................................................................................1552 ANTIMONY/OXIDATTVE STRESS/HEART ...................................................................................................................................................... 608 ANTIMUTAGEN/AFLATOXIN Bi/COUMARIN..................................................................................................................................................48 ANTINEOPLASTIC DRUGS/VINCA ALKALOIDS/RENAL TRANSPORT............................................................................................... 186 ANTIOXIDANT/LIPID PEROXIDATION/CALCIUM..................................................................................................................................... 621 ANTIOXIDANT/HETEROCYCLIC AMINE/CHEMOPREVENTION ......................................................................................................... 638 ANTIOXIDANT/CADMIUM/GLUTATHIONE.................................................................................................................................................... 881 ANTIOXIDANT/HETEROCYCLIC AMINE/CHEMOPREVENTION ..........................................................................................................958 ANTIOXIDANT/DINITROBENZENE/ENCEPHALOPATHY....................................................................................................................... 1343 ANTIOXIDANT/MASS SPECTROMETRY/HPLC........................................................................................................................................... 1566 , ANTIOXIDANT/PHENOLS/FREE RADICALS ................................................................................................................................................ 1579 1 ANTIOXIDANT GENE/ATX 1/SOD........................................................................................................................................................................ 441 I ANTIOXIDANT PROTECTION/VITAMIN AND SELENIUM/OZONE TOXICITY................................................................................. 632 ; ANTIOXIDANT SYSTEM/TOXICITY/CHROMIUM....................................................................................................................................... 1005 ! ANTTPLATELET/NIPECOTAMIDES/AGGREGATION INHIBITORS ......................................................................................................1553 j ANTIPS YCHOTIC/OLANZAPINE/PROGENITOR CELLS/STEM CELLS/HEMATOPOIETIC/BONE MARROW..................... 1549 I ANXIOLYTIC/LIPID/LIVER ..................................................................................................................................................................................1107 | AORTA/ELASTIN/AMINE OXIDASE.................................................................................................................................................................. 1481 AP-1 TRANSCRIPTION FACTOR/ONCOGENE EXPRESSION/CC14 TOXICITY INHIBITORS/INDUCERS................................ 515 APLASTIC ANAEMIA/TOXIC CYSTEINE CONJUGATES/RENAL INJURY CATTLE.........................................................................194 APOPTOSIS/RAS-ONCOGENE/OKADAIC ACID.............................................................................................................................................. 167 APOPTOSIS/LEAD/RETINA .................................................................................................................................................................................. 1123 APOPTOSIS/CHROMIUM/CARCINOGENESIS .............................................................................................................................................. 1154 apoptosis/acetaminophen/cytoprotection......................... APOPTOSIS/2-METHOXYETHANOL/THYMUS .................................... APOPTOSIS/2-METHOXYETHANOUTESTES........................................ APOPTOSIS/GLUCOCORTICOIDS/IMMUNOSUPPRESSION........... APOPTOSIS/TCDD/PROLACTIN ................................................................. APOPTOSIS/FLOW CYTOMETRY/CELL DEATH.................................. APOPTOSIS/THYMOCYTES/DNA FRAGMENTS .................................. APOPTOSIS/EARLY GENE EXPRESSION/TISSUE REPAIR .............. APOPTOSIS/CALCIUM/PHOSPHORYLATION ...................................... APOPTOSIS/CYANIDE/DNA FRAGMENTATION.................................. APOPTOSIS/LUNG/RADIATION ................................................................. APOPTOSIS/TERATOGENESIS/CYCLOPHOSPHAMIDE.................... APOPTOSIS/2-METHOXYETHANOL/CYCLOHEXIMIDE.................. APOPTOSIS/THAPSIGARGIN/CALCIUM................................................. APOPTOSIS/PROTEIN SYNTHESIS/THYMOCYTES............................. APPETITE SUPPRESSION/TCDD/GLUCONEOGENESIS.................... AQUATIC/AVIAN/REPELLENT................................................................... AQUATIC/STRESS PROTEINS/BIOMONITORING............................... AQUATIC/SURFACTANTS/IN VITRO........................................................ AQUATIC/METALLOTHIONEIN/METALS............................................... AQUATIC/METALLOTHIONEIN/METALS............................................... AQUATIC TOXICOLOGY/CYTOCHROME P-450 1A/BIOMARKERS ARACHIDONIC ACID/P450/PEROXYGENASE ...................................... ARACHIDONIC ACID/SKIN IRRITATION/IN VITRO........................... ARNT/TCDD/AH RECEPTOR ........................................................................ ARNT/DIOXIN/AH-RECEPTOR ................................................................... AROCLOR/LIVER/PCBS ................................................................................ AROMATASE/C8/PEROXISOME PROLIFERATION........... ................. AROMATIC AMINES/CARCINOGENIC HAZARD/RISK ASSESSMENT/STRUCTURE-ACTTVTTY RELATIONSHIP ANAL..................................................................................... ..................................................... ARSENIC/CARdNOGENICITY/RISK ASSESSMENT............................... ..................................................... ARSENIC/EPA GUIDELINES/RISK ASSESSMENT......................................................................................... ARSENIC/GLUTATHIONE/PHARMACOKINETICS/TOXICOKINETICS................................................. ARSENIC/INSOLUBLE/MACROPHAGES........................................................................................................... ARSENIC/PROBABILISTIC RISK ASSESSMENT/STOCHASTIC RISK ASSESSMENT...................... ARSENIC/COMPARATTVE/TOXICOLOGY......................................................................................................... ARSENIC/GLUTATHIONE/REDOX...................................................................................................................... ARSENIC/GLUTATHIONE/ERYTHROCYTE.................................................................................................... ARSENIC/GLUTATHIONE/ERYTHROCYTE.................................................................................................... ARSENIC/GLUTATHIONE/THIN-LAYER CHROMATOGRAPHY ............................................................ ARSENICALS/SKIN/ABSORPTION...................................................................................................................... ARSINE/HEMOLYSIS/IN VITRO ........................................................................................................................... ARSINE/ANEMIA/INHALATION........................................................................................................................... ARTERIOPATHY/HAEMODYNAMIC/PDEm INHIBITOR .......................................................................... ARTERIOSCLEROSIS/ACCELERATION/ENVIRONMENTAL TOBACCO SMOKE............................. ARTERIOSCLEROTIC/TOBACCO SMOKE/LUNG CANCER....................................................................... ASBESTOS/FREE RADICALS/DNA STRAND BREAKS................................................................................ ASBESTOS/CANCER ................................................................................................................................................. ASBESTOS FIBERS/SIZE-SELECTED/CHRYSOTILE..................................................................................... ASCORBIC ACID/AVIAN/GLUTATHIONE....................................................................................................... ASCORBIC ACID/UROPORPHYRIN/5-AMINOLEVULINATE ................................................................... ASPARTATE/ASTROCYTES/METHYLMERCURY......................................................................................... ASPARTATE/ASTROCYTES/MERCURY ........................................................................................................... ASSAY/BACTERIAL/GENOTOXICITY............................................................................................................... ASSESSMENT/NONCANCER/RISK.................................................................................................................... 474 U55 US6 1157 1158 1159 1160 1161 1180 1419 1420 1421 1422 1424 1425 1426 1505 .926 1433 .1649 .1652 1653 .114 ..109 .335 ..234 .1033 .1458 .1163 -.453 ...51 ...52 ...68 ..242 ..551 ..800 .1014 .1015 .1016 .1017 ..355 ..320 .1590 .1483 ..722 ..718 ..855 .1666 ..152 ..661 .1103 .1110 .1112 1285a .1592 astm ASTRC ASTR( ASTRC ASTR( ASTRC ASTRC ataxi ataxi ATHEI ATP/El atp/c atroi atxi/i audit audit aurin auto/ auto/ auto/ auto/ auto/ autol autoe AUTO! auton auton AUTOP AVIAN. AVIAN, AVIAN, AVIAN/ AXIOL2 AXON I AXONA AXONA AXONA AXONA AXONC AZARC AZOLE AZOLE AZT/PY B-OXID BACTE! BACTEI BAP-CO BASOL/ BATRA( bayks BCL-2/N BCL-2T BCOP/IF BEHAV1 BEHAV1 H55 156 157 158 159 160 161 180 419 420 421 1422 1424 1425 1426 1505 926 1433 1649 1652 1653 114 109 .335 234 1033 1458 1163 .453 . .51 . .52 . .68 .242 .551 .800 014 015 016 017 355 .320 1590 1483 .722 .718 .855 1666 .152 .661 1103 1110 1112 285a 1592 ^TM E981/CARPETS/SENSORY IRRITATION................................................................................................................................................ 969 ASTROCYTES/MORPHOMETRICS/METHYLMERCURY............................................................................................................................990 ASTROCYTES/GLUTATHIONE/MONOCHLOROACETIC ACID .............................................................................................................1057 ASTROCYTES/METHYLMERCURY/ASPARTATE........................................................................................................................................1110 astrocytes/mercury/aspartate......................................................................................................................................................... 1112 ASTROCYTES/METHAMPHETAMINE/6-HYDROXYDOPAMINE.......................................................................................................... 1345 ASTROGLlA/GLUTATHIONE/FELINE IMMUNODEFICIENCY VIRUS (FTV) .................................................................................... 1347 ATAXIA/2,4-DITHIOBIURET/MEMORY............................................................................................................................................................. 294 ATAXIA TELANGIECTASIA/REPRODUCnON/RADIATION..................................................................................................................... 844 ATHEROGENESIS/ENDOTHELLAIVCYTOCHROME................................................................................................................ 1482 ATP/ENERGY CHARGE/ALLYL ALCOHOL ...................................................................................................................................................1447 ATP/CALCIUM/PURINERGIC RECEPTORS..................................................................................................................................................... 1492 ATROPINE/MEMANTTNE/OXAMYL/METHOMYL........................................................................................................................................1545 ATXl/SOD/ANTIOXIDANTGENE........................................................................................................................................................................ 441 AUDITORY PATHWAY/LESIONS/DINITROBENZENE...............................................................................................................................1342 AUDITORY SYSTEM/CARBON MONOXIDE/GLUTAMATE ................................................................................................................... 1334 AURINTRICARBOXYLIC ACID/ENZYME/INHIBrnON ............................................................................................................................ 1493 AUTOANTIBODY/MERCURY/NEUROTOXICITY ....................................................................................................................................... 1116 AUTOANTmODY/LEAD/NEUROTOXICITY...................................................................................................................................................1117 AUTOANTffiODY/CADMIUM/NEUROTOXICITY ....................................................................................................................................... 1118 AUTOANTIBODY/LEAD/NEUROTOXICITY...................................................................................................................................................1119 AUTOANTIBOGY/OPIDN/NEUROTOXICITY................................. 1331 AUTOIMMUNITY/METHYLMERCURY/T AND B LINEAGE CELLS...................................................................................................... 1251 AUTOIMMUNITY/TCDD/EXTRATHYMICT-CELLS ................................................................................................................................... 1253 AUTOMATED/METHEMOGLOBIN/ANALYSIS ............................................................................................................................................ 1572 AUTOMATED EXPOSURES/EXPOSURE CONTROL/INHALATION EXPOSURES..............................................................................157 AUTOMATED IMAGE ANALYSIS/REPRODUCTIVE TOXICANTS/RAT SPERM MORPHOMETRY............................................205 AUTOPROTECTION/TISSUE REPAIR/THIOACETAMIDE.............................................................................................................................. 41 AVIAN/GLUTATHIONE/ASCORBIC ACID.........................................................................................................................................................661 AVIAN/ORGANOPHOSPHATES/CHOLINESTERASES ................................................................................................................................ 908 AVIAN/REPELLENT/AQUATIC.............................................................................................................................................................................926 AVIAN/DYSMORPHOGENESIS/TERATOGENESIS ..................................................................................................................................... 1503 AXIOLYTIC/SEROTININ/REPRODUCTION...................................................................................................................................................... 576 AXON BRANCHING/HIPPOCAMPAL NEURONS/NICOTINE..................................................................................................................... 509 AXONAL TRANSPORT/CYTOSKELETON/GUAL CELLS................................................................................................................................ 3 AXONAL TRANSPORT/NEUROTOXICOLOGY/IN VITRO ..........................................................................................................................758 AXONAL TRANSPORT/TAXOL/NEUROPATHY..............................................................................................................................................759 AXONAL TRANSPORT/ACRYLAMIDE/KINESIN........................................................................................................................................... 766 AXONOPATHY/DISULFIRAM/CARBON DISULFIDE .................................................................................................................................. 763 AZARCON/LEAD/FOLK-MEDICINES..................................................................................................................................................................896 AZOLE ANTIFUNGALS/CYTOTOXICITY/HEPATOCYTES ........................................................................................................................325 AZOLES/GENE EXPRESSION/EPOXIDE HYDROLASE...................................................................................................................................89 AZT/PYRIMETHAMINE/ZIDOVUDINE................................................................................................................................................................529 B-OXIDATION/LIVER/MITOCHONDRIA........................................................................................................................................................... 707 BACTERIAL/GENOTOXICITY/ASSAY............................................................................................................................................................ 1285a BACTERIAL CHALLENGE/INTERLEUKIN-1 RECEPTOR ANTAGONIST/HOST RESISTANCE...................................................1403 BAP-COATED PARTICLE/PULMONARY ALVEOLAR MACROPHAGE/METABOLISM................................................................1315 BASOLATERAL HG TRANSPORT/PROXIMAL TUBULE/ISOLATED PERFUSED TUBULE........................................................... 996 BATRACYLIN/N-ACETYLATION/GENOTOXICITY .....................................................................................................................................836 BAY K 8644/RABBIT PAPILLARY MUSCLE/RICIN ..................................................................................................................................... 1487 BCL-2/METHYL MERCURY/FREE RADICAL/OXIDANT INJURY............................................................................................................ 609 BCL-2 TRANSGENIC MICE/TCDD/THYMIC ATROPHY.............................................................................................................................1395 BCOP/IRRITATION/EYE ...........................................................................................................................................................................................310 BEHAVIOR/NURSING DISORDER/HORMONE................................................................................................................................................ 219 BEHAVIOR/LIPOPOLYSACCHARIDE/PROSTAGLANDIN..........................................................................................................................291 475 BEHAVIOR/SIGNAL PROCESSING/STARTLE RESPGNSE BEHAVIOR/RATS/ACOUSTIC STARTLE............................... BEHAVIOR/ZALCITABTNE/HYDROCEPHALUS.................. BEHAVIOR/METHYLMERCURY/MICE.................................. BEHAVIOR/CNS/MERCURIC CHLORIDE ............................. BEHAVIOR/RISK ASSESSMENT/SOLVENTS ....................... BEHAVIORAL MEASURES/OZONE DEPLETING SUBSTANCE REPLACEMEN/R- I34A BEHAVIORAL TOLERANCE/NEUROTRANSMITTERS/PHOSALONE TOXICITY......... BENCHMARK DOSE/DOSE-RESPONSE/SUBCHRONIC .......................................................... BENCHMARK DOSE METHOD/CHROMIUM/REFERENCE CONCENTRATION............. BENEFICIAL PLANTS/NONTARGET ORGANISMS/INSECTICIDAL PLANTS ................ BENZENE/LYMPHOCYTE/GENE EXPRESSION.......................................................................... BENZENE/CHROMOSOME ABERRATIONS/INTERACTION................................................. BF.NZENE/HPRT MUTATION/GLUTATHIONE TRANSFERASE ........................................... BENZENE/METABOLISM/MUCONALDEHYDE METABOLITES ........................................ BENZENE/HEMATOTOXICITY/GUNN RAT ................................................................................ BENZENE/ACCELERATOR MASS SPECTROMETRY/BIODOSIMETRY ........................... BENZIDINE/CARCINOGEN POTENCY/4-AMINOBIPHENYL................................................. BENZO(A)PYRENE/IMMUNOTOXICOLOGY/ULTRAVIOLET LIGHT............................... BENZO(A)PYRENE/PROLIFERATION/MESANGIAL................................................................. BENZO(A)PYRENE/SMOOTH MUSCLE CELLS/PROTO-ONCOGENE ............................... BENZO(A)PYRENE/C-HA-RAS/SMOOTH MUSCLE CELLS ................................................... BENZO(A)PYRENE/EGF RECEPTOR/HCG..................................................................................... BENZO(A)PYRENE/CYTOCHROME P-45Q/MICRONUCLEUS ............................................... BENZO(A)PYRENE/NUCLEOSOMES/POLYMERASE............................................................... BENZO(A)PYRENE/TERATOGENESIS/P53 ................................................................................... BENZO(A)PYRNE/TRANSGENIC MICE/MUTAGENICITY.................................................... BENZO(A)PYRENE/DNA ADDUCT/O-XYLENE .......................................................................... BENZO(A)PYRENE/ADDUCTS/URINARY METABOLITES .................................................... BENZO(A)PYRENE/STROMAL CELLS/MITOCHONDRIA ...................................................... BENZO(A)PYRENE/HEMATOPOIETTC/FETAL............................................................................ BENZO(A)PYRENE/INDUCED CATEIS H/INTESTINAL BIOTRANSFORMATION......... B ENZO(A)PYRENE/BIOAV AILABILOY/INDUCTION............................................................... BENZODIAZEPINE/CYTOCHROME P-450/GLUTATHIONE.................................................... BENZOPHENONE/DOSED FEED/LIVER TOXICITY................................................................... BENZO[A]PYRENE/AH RECEFTOR/TCDD ................................................................................... BENZYL QUINOLINIUM/TRANSPORT/TUBULES..................................................................... BENZYLTRIMETHYLAMMONIUM CHLORIDE/METABOLISM/DISPOSITION............. BERBERINE/CELLCYCLE/HEPG2 CELLS..................................................................................... BERYLLIUM/INHALATION/CARCTNOGENICITY..................................................................... BERYLLIUM/ANTIBODIES/CALCIUM............................................................................................ BETA-IONONE/CYTOCHROME P-450/COCAINEIMMUNOTOXICITY............................. BETA-NAPHTHOFLAVONE/INDOLE-3-CARBINOL/AFLATOXIN B i.................................. BILE/PEROXISOME PROLIFERATORS/LIVER SLICE............................................................... BILE/TRANSPORTERS/DICHLOROETHYLENE.......................................................................... BILE/EXCRETION/P-GLYCOPROTEIN............................................................................................ BILE/NICOTINE/GLUCURONIDES .................................................................................................. BILE ACID SEQUESTERANT/CHOLESTYRAMINE/NECROSIS............................................. BILE DUCT INJURY/BILIARY EXCRETION/METHYLENE DIANILINE............................. BILE DUCTULAR STEM-UKE CELL .............................................................................................. BILIARY/CELL/BIOLOGY..................................................................................................................... BILIARY EPITHELIUM/CELL PROLIFERATION/HEPATOBILIARY FUNCTION........... BILIARY EPITHELIUM/PROLIFERATION..................................................................................... BILIARY EPITHELIUM/HYPERPLASIA/BILIARY OBSTRUCTION...................................... BILIARY EPITHELIUM/HEPATOCYTES/CHARACTERIZATION ........................................ 476 '-30la -321 992 "993 1430 290 1358 1588 ....... 59 1540 746 1274 1278 1311 1554 1703 .473 ........14 .165 .511 .512 .727 .837 .839 ... .940 ....941 .. .1293 ...1416 ...1551 ...1559 ...1708 ...1709 ........94 ... .829 ...1034 ....188 .. .1722 ....783 ...1011 ...1012 ... .954 ........ 42 ........ 36 ... .680 ...1439 ...1706 ...1090 ...1445 ....717 ... .713 ....431 ....432 . .. .716 ...1091 Bn 8 tt BOBO BO. BO. BO. Bl> BO' BI> BIC BIC BIC BIC BIC BIC BIC BIO BIO BIC BIC BIC BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO BIO 51 BILIARY EPITHELIUM/CELL PR'OLIFERATION/TRnODOTHYRONINE................................................................................ 1092 BILIARYEPITHELIUM/HEPATOCYTES/CHARACTERIZATION ............................................................................................ 1093 BILIARY EXCRETION/METABOLISM/METHACRYLONITRILE.............................................................................................. 1304 BILIARY EXCRETION/METHYLENE DIANILINE/BILE DUCT INJURY.................................................................................. 1445 BILIARY HYPERPLASIA/BILIARY TREE/HEPATOBILIARY TOXICITY.................................................................................. 712 BILIARY OBSTRUCTION/BILIARY EPITHELIUM/HYPERPLASIA........................................................................................... 716 BILIARY TREE/HEPATOBILIARY TOXICITY/BILIARY HYPERPLASIA..................................................................................712 BILIARY TREE/CHEMICAL INJURY/MORPHOLOGIC RESPONSE........................................................................................... 714 BINDING/CLAY/SECALONIC ACID D ..........................................................................................................................................790 BINDING/CLAY/CYCLOPIAZONICACID .................................................................................................................................... 791 BINDING/HEXACHLOROBENZENE/PORPHYRIA..................................................................................................................... 1698 BIOACCUMULATION/LEAD/MINE-ORES.................................................................................................................................... 561 BioACTIVATION/ACETAMINOPHEN/DTP VACCINE .................................................................................................................95 BlOACTIVATION/NEPHROTOXICrrY/HEPATOTOXICITY....................................................................................................... 170 BIOACTIVATION/MECHANISM-BASEDINACTTVATION/CYTOCHROME P450 2B1............................................................ 499 BIOACTIVATION/IN VITRO/ANTICHOLINESTERASE...............................................................................................................905 BlOACnVATION/HUMAN LUNG/AFLATOXIN B i ...................................................................................................................1305 BIOALKYLATION/POLYNUCLEAR AROMATIC HYDROCARBONS/METABOLISM........................................................... 1290 BIOASSAY/GENOTOXICITY/MUTATION.................................................................................................................................1285b BIOAVAILABILITY/LEAD/MICROSWINE.................................................................................................................................... 560 BIOAVAILABILITY/STOMACH PH/DIDEOXYINOSINE.............................................................................................................379 BIOAVAILABILITY/TOXICOKINETICS/CHROMIUM....................................... 383 BIOAVAILABILITY/STYRENE/STYRENE OXIDE .......................................................................................................................390 BIOAVAILABILITY/LEAD/MICROSWINE.................................................................................................................................... 560 BIOAVAILABILITY/ABSORBED DOSE/SKIN RESERVOIR ....................................................................................................... 662 BIOAVAILABILITY/BIODEGRADATION/PLASTICS................................................................................................................. 1659 BlOAVAILABILITY/INDUCTTON/BENZO(A)PYRENE............................................................................................................... 1709 BIOAVAILABLE/COMPOST/nUNITROTOLUENE (TNT)......................................................................................................... 1636 BIOCHEMICAL EFFECTS/TCDD/FEMALE RATS.......................................................................................................................1041 BIODEGRADATION/MYCOBACTERIA/PHYLOGENY............................................................................................................. 1630 BIODEGRADATION/PLASTICS/BIOAVAILABILITY................................................................................................................. 1659 BIODETOXIFICATION/ORGANOPHOSPHATE HYDROLYSIS/ORGANOPHOSPHORUS HYDROLASE (OPH) ................ 1527 BIODOSIMETRY/BENZENE/ACCELERATOR MASS SPECTROMETRY ................................................................................ 1703 BIOLOGIC MARKERS/COVALENT BINDING/ACRYLONITRILE............................................................................................1406 BIOLOGIC MARKERS/PORPHYRINS/ENVIRONMENTAL TOXICOLOGY ............................................................................ 1639 BIOLOGICAL MARKERS/RESPIRATORY/BRONCHOVEOLAR LAVAGE.............................................................................. 1663 j BIOLOGICALMONTTORING/PARA-NITROPHENOL/NITROBENZENE.................................................................................. 1571 j BIOLOGY/BILIARY/CELL............................................................................................................................................................... 713 BIOMARKERS/IGA/SALIVA............................. 7:....................................................................................................................... 13 ! BIOMARKERS/AQUATIC TOXICOLOGY/CYTOCHROME P-4501 A ........................................................................................ 114 BIOMARKERS/LEAD/HEME PATHWAY PARAMETERS ...........................................................................................................253 BIOMARKERS/MIXTURES/CARCINOGENESIS.......................................................................................................................... 471 BIOMARKERS/SPHINGOLIPID METABOLISM/FUMONISIN..................................................................................................... 770 BIOMARKERS/CARBOFURAN/METHYL PARATHION ............................................................................................................ 916 BIOMARKERS/METHYLENEDEPHENYL DHSOCYNATE (MDI)/DISTRIBUTION .................................................................1410 BIOMARKERS/PROTEIN ADDUCTS/METHYLENEDIPHENYL DDSOCYANTE (MDI)......................................................... 1411 BIOMARKERS/GC-MS ANALYSIS/TOULENE DIISOCYNATE (TDD ...................................................................................... 1412 BIOMARKERS/HEMOGLOBIN ADDUCTS/PYRROLES............................................................................................................. 1415 BIOMARKERS/EARTHWORM/GENOTOXICITY .......................................................................................................................1637 BIOMARKERS/CYTOCHROME P-450/WILDLIFE.......................................................................................................................1638 BIOMARKERS/IMMUNOSUPPRESSION/CATFISH ...................................................................................................................1654 BIOMARKERS/FISH/PAHS ............................................................................................................................................................1657 BIOMONTTORING/HEMOGLOBIN/SULFHYDRYL GROUPS ..................................................................................................... 655 BIOMONITORING/AQUATIC/STRESS PROTEINS ..................................................................................................................... 1433 BIOSYNTHESIS/GLUTATHIONE/CELL NUCLEUS .................................................................................................................... 642 477 BIOTECHNOLOGY/BLDOD PRODUCT/RECOMBINANT.................................................................................................................. BIOTECHNOLOGY/PRECLIN1CAL SAFETY/BRAIN NATRIURETIC PEPTIDE (BNP)........................................................ " " 24 BIOTRANFORMATION',"PHASE I/MIXTURES/TOXICOKINETICS ............................................................................................ " BIOTRANSFORMATION/CYTOCHROME P-450/ACETAMINOPHEN....................................................................................... BIOTRANSFORMATION/DCVC/b-LYASE........................................................................................................................................... la! BIOTRANSFORMATION/SOLVENTS/TOXICOKINETICS................................................................................................................ " " 8 BIOTRANSFORMATION/ANTIARRHYTHMIC/BRB-I-28 ..................................................................................................................' ' BIOTRANSFORMATION/ACETYLAMINOFLUORENE/HEPATOCARCINOGENESIS.............................................................. g BIOTRANSFORMATION/METABOLITES/HYDROCHLOROFLUOROCARBONS....................................................................... , ' BIOTRANSFORMATION/COCAINE/HUMAN FETAL TISSUE ......................................................................................................... ' ,08? BIOTRANSFORMATION/FLUORINATED ETHERS/CYTOCHROME P-450 2E1 .......................................................................... ' , a6 BIOTRANSFORMATION/CHANNEL CATFISH/AFLATOXIN B i .........................................................................................................' 128? BIOTRANSFORMATION/HUMAN TISSUES/SUBJECTS/CYTOCHROME P-450 ............................................................................ 1307 BIOTRANSFORMATION/OCULAR/ALDOSE REDUCTASE INHIBITORS ..........................................................................................131J BIOTRANSFORMATION/ENDOCRINE SYSTEM/UVER........................................................................................................................... l33fl BIOTRANSFORMATION/WR-2721/PLATINUM ...........................................................................................................................................l707 BIOTRANSFORMATION/NEONATES/SEVOFLURANE............................................................................................................................. 1718 BIOTRANSFORMATION/PHARMACOKINETICS/SMALL INTESTINE................................................................................................ 172j BIOTRANSFORMATION, PHASE l/BIOTRANSFORMATION, PHASE 2 ............................................................................................1303 BIS-(2-CHLOROETHYL) SULFIDE/PSEUDO-EPIDERMIS/WATER PERMEATION BARRIER ..................................................... 343 BIS-(2-CHLOROETHYL) SULFIDE/KERATINOCYTES/DIFFERENTIATION.......................................................................................353 BIS-(2-CHLOROETHYL)-SULFIDE/KERATINOCYTES/CELLCYCLE .................................................................................................. 352 BISPHENOL A/GENOTOXICITY/ESTROGEN ................................................................................................................................................1270 BISULFTTE/NERVE/ANESTHESIA......................................................................................................................................................................134$ BLEEDING/JUGULAR VEIN/RATS ..................................................................................................................................................................... 862 BLEEDING TIME/GP HB/niA/DMP 728 .............................................................................................................................................................. 817 BLOOD CONCENTRATIONS/GAVAGE VOLUME/CHLOROFORM ....................................................................................................... 179 BLOOD GASES/MICROCAPNOMETRY/CARBON DIOXIDE ....................................................................................................................864 BLOOD LEAD/RISK ASSESSMENT/EXPOSURE MODELING ................................................................................................................... 53 BLOOD LEAD/PREDICTIVE MODELS/RISK ASSESSMENT........................................................................................... 57 BLOOD LEAD/CHILDREN/IRON INTAKE........................................................................................................................................................257 BLOOD LEAD/DIETARY CALCIUM/CHILDREN .......................................................................................................................................... 258 BLOOD LEAD/CHILDREN/DIETARY FAT........................................................................................................................................................893 BLOOD PLASMA, HUMAN/CYSTEINE/GLUTATHIONE............................................................................................................................. 639 BLOOD PRODUCT/RECOMBINANT/BIOTECHNOLOGY.............................................................................................................................24 BLOOD SUBSTTTUTE/CARDIOVASCULAR/HYPOVOLEMIC SHOCK.................................................................................................1477 BLOOD-BRAIN BARRIER/CHELATOR/3-HYDROXYPYRIDIN-4-ONE.................................................................................................1000 BLOOD-BRAIN BARRIER/TRANSPORT/MANGANESE ............................................................................................................................1108 BLOOD-BRAIN BARRIER/AMINO ACID TRANSPORT SYSTEM UMETHYLMERCURY.............................................................1184 BLOOD-BRAIN BARRIER/METHYLMERCURY/GLUTATHIONE............................. 1185 BLOOD-LEAD/TOXICOKINETICS/BONE LEAD.............................................................................................................................................259 BODY COMPOSITION/ADRENERGIC AGONIST/BODY MASS................................................................................................................808 BODY MASS/BODY COMPOSITION/ADRENERGIC AGONIST................................................................................................................808 BODYWEIGHT/INFUSION/RATS..........................................................................................................................................................................860 BODYWEIGHT/INFUSION/DOG............................................................................................................................................................................ 867 BODYWEIGHT/SURVIVAL/SPRAGUE-DAWLEY RAT.............................................................................................................................. 1178 BONE/CHROMIUM/DISTRIBUTION..................................................... 1003 BONE LEAD/BLOOD-LEAD/TOXICOKINETICS................................................................................................... 259 BONE MARROW/BUTADIENE/BUTADIENE MONOXIDE......................................................................................................................... 366 BONE MARROW/THYMUS/T-2 TOXIN .............................................................................................................................................................416 BONE METABOLISM/SULFATED POLYSACCHARIDE/OSTEOPOROSIS...........................................................................................1498 BONE REMODELING/HISTOMORPHOMETRY/CADMIUM..................................................................................................................... 1190 BONE RESORPTION/OSTEOCLASTS/CADMIUM........................................................................................................................................... 874 BORIC ACID/TESTIS/RECOVERY........................................................................................................................................................................270 BOTl pRAl 0RAI BRA1 brai 0RAI brai brai brai brai brbbrbbrd> brr BRE' bria bro: bro: bro: BRO bro bro bro BRO BRO BRO BRO BRO BUT BUT BUT BUT BUT BUT BUI BUT BUI BU C-I C^ C8/ CA CA CA, CA1 CA1 CAI CAJ CA) CA) CA CA CA CA CA 511904 0201 gOTULINUM/lNHALATION/AEROSOUTOXICITY..................................................................................................................................... 1670 3RAIN/LEAD/METAL-BINDINGPRQTEINS.................................. 302 BRAIN/METALLOTHIONEIN/GENE EXPRESSION ............................................................................................................................. 891 brain/metals/metallothionein.......................................................................................................................................................... u 11 3RAIN/NCAM/METHYLMERCURY .................................................................................................................................................................. 1114 BRAIN/SEROTONIN/LEAD.....................................................................................................................................................................................1126 BRAIN/DOPAMINE/LEAD.......................................................................................................................................................................................1127 BRAIN NATRIURETIC PEPTIDE (BNP)/BIOTECHNOLOGY/PRECLINICAL SAFETY.......................................................................182 BRAIN NUCLEI/TCDD/SEXUAL DIFFERENTIATION...................................................................................................................................731 j BRAINSTEM AUDITORY EVOKED POTENTIAIj'3,3'-IMINODIPROPIONITRILE/REFLEX MODIFICATION........................1363 i 8RB-I-28/GLG-V-13/TOXICITY ............................................................................................................................................................................. 806 i BRB-I-28/BIOTRANSFORMATION/ANTIARRHYTHMIC ............................................................................................................................ 807 0RDU/CELLPROLIFERATION/PHENOBARBITAL ..................................................................................................................................... 1569 BREAST CANCER CELLS/ICZ/CYTOCHROME P-450 .................................................................................................................................. 728 BREAST MILK/TETRACHLOROETHYLENE/PBPK ......................................................................................................................................... 86 BRIMONIDINE/EYE/MONKEYS.............................................................................................................................................................................975 BROMOBENZENE/HEPATOTOXICITY/ADRENERGIC ANTAGONISTS ...............................................................................................699 BROMOBENZENE/ADDUCTS/ANTIBODIES.................................................................................................................................................. 1700 BROMODEOXYURIDEINE/S-PHASE/QUANnTATION.............................................................................................................................. 1106 BROMODICHLOROACETATE/OXALATE/TRICHLOROACETATE........................................................................................................ 1464 BROMODICHLOROMETHANE/CHLOROFORM/NEPHROTOXICITY....................................................................................................1075 BROMODICHLOROMETHANE/BROMOFORM/NEPHROTOXICITY ....................................................................................................1076 BROMOFORM/NEPHROTOXICITY/BROMODICHLOROMETHANE ....................................................................................................1076 BROMOPHENYLACETYLUREA/FUNCTIONAL OBSERVATIONAL BATTERY/NEUROPATHY.............................................. 1350 BROMOPHENYLACTYLUREA/NEUROPATHY/UBIQUITIN................................................................................................................... 1357 BROMOTHIOCATECHOL/METHYLATION/METHIONINEyS-ADENOSYLMETHIONINE................................................................372 BRONCHO-ALVEOLAR LAVAGE/OZONE/AGING ..................................................................................................................................... 1224 BRONCHOVEOLAR LAVAGE/BIOLOGICAL MARKERS/RESPIRATORY...........................................................................................1663 ! BUTADIENE/CYTOCHROME P-450/SEX-RELATED DIFFERENCES ...................................................................................................... 101 ! BUTADIENE/BUTADIENE MONOXIDE/BONE MARROW................................ 366 j BUTADIENE/BUTADIENE MONOXIDE/SOLVOLYTIC PRODUCTS....................................................................................................... 367 j BUTADIENE/BUTADIENE MONOXIDE/DNA ADDUCTS........................................................................................................................... 854 ; B UTADIENE/METABOLITES/GC/MS............................................................................................................................................................... 1413 j BUTADIENE EPOXIDE/1,3-BUTADIENE/METABOLISM ..........................................................................................................................1235 BUTADIENE MONOXIDE/BONE MARROW/BUTADIENE......................................................................................................................... 366 BUTADIENE MONOXIDE/SOLVOLYTIC PRODUCTS/BUTADIENE....................................................................................................... 367 BUTADIENE MONOXIDE/DNA ADDUCTS/BUTADIENE............................................................................................................................854 BUTYL NITRITE/NITRITE/DNA DEAMINATION........................................................................................................................................... 856 C-HA-RAS/SMOOTH MUSCLE CELLS/BENZO(A)PYRENE ....................................................................................................................... 512 C-MYC/CELL PROLIFERATION/NICOTINE ....................................................................................................................................................427 C8/PEROXISOME PROLIFERATION/AROMATASE.....................................................................................................................................1163 CADMIUM/ANTICARCINOGENIC/LIVER...........................................................................................................................................................38 . CADMIUM/TOXICOKINETTCS/RISK ASSESSMENT.......................................................................................................................................62 CADMIUM/METALLOTHIONEIN/LUNG........................................................................................................................................................... 144 CADMIUM/TESTIS/SERTOLI CELL/HSP27/STRESS PROTEIN................................................................................................................... 269 CADMIUM/CELL PROLIFERATION/HUMAN PLACENTA......................................................................................................................... 425 CADMIUM/GENE MUTATION/OXYGEN RADICALS .................................................................................................................................. 849 CADMIUM/ROS 17/2.8/KINETICS ........................................................................................................................................................................ 870 I CADMIUM/CARDIOMYOCYTES/CALCIUM................................................................................................................................................. ,.871 ; CADMIUM/ESTERASES/METABOLISM........................................................................ .872 ; CADMIUM/PEROXISOME/YEAST.........................................................................................................................................................................873 i CADMIUM/BONE RESORPTION/OSTEOCLASTS................................................................................ 874 CADMIUM/SELENIUM/METALLOTHIONEIN.................................................................................................................................................. 875 CADMIUM/MACROPHAGES/CYTOTOXICITY................................................................................................................................................ 876 CADMIUM/IMMUNOTOXICOLOGY/IN VITRO METAL TOXICITY........................................................................................................877 CADMIUM/CYTOSKELETON/TraOL HOMEOSTASIS .... CADMIUM/GLUTATHIONE/ANTIOXIDANT........................... CADMIUM/ETHANOL/TOXICITY ............................................... CADMIUM/HUMAN PLACENTA/METALLOTHIONEIN ... CADMIUM/GENOTOXICITY/METALLOTHIONEIN.............. CADMIUM/METALLOTHIONEIN/HEPATOTOXICITY .... CADMIUM/CISPLATIN/METALLOTHIONEIN ...................... CADMIUM/NEUROTOXICITY/AUTOANTIBODY................ CADMIUM/DOPAMINE/RELEASE ............................................. CADMIUM/METALLOTHIONEIN/PROTO-ONCOGENE ... CADMIUM/BONE REMODELING/HISTOMORPHOMETRY CADMIUM INHIBITOR/CALCIUM/METALLOTHIONEIN .. CADMIUM/VERAPAMIL/HEPATIC CYTOCHROME P450/KETAMINEL ANESTHESIA CAFFEINE/HEPATOCYTES/DOSE-DEPENDENT HEPATOTOXICITY............................... CAFFEINE/POLYMORPHISM............................................................................................................. CAFFEINE/HEPATOCYTES/ALLYL ALCOHOL .......................................................................... CAGED CALCIUM MEDIATORS/IP3/CALCIUM.......................................................................... CALCIUM/OSTEOCALCIN/LEAD .................................................................................................... CALCIUM/LEAD/NEURONS................................................................................................................ CALCIUM/NEURONS/TCDD................................................................................................................ CALCIUM/MITOCHONDRIA/DOXORUBICIN.............................................................................. CALCIUM/MITOCHONDRIA/QUINONES....................................................................................... CALCIUM/MITOCHONDRIA/MENADIONE................................................................................... CALCIUM/T-BUTYLHYDROPEROXIDE/MrTOCHONDRIA................................................... CALCIUM/ANTIOXIDANT/LIPID PEROXIDATION................................................................... CALCIUM/CADMIUM/CARDIOMYOCYTES................................................................................ CALCIUM/LEAD/ANION...................................................................................................................... CALCIUM/NEUTROPHILS/POLYCHLORINATED BIPHENYLS............................................. CALCIUM/IMMUNOTOXICITY/POLYCYCLIC AROMATIC HYDROCARBONS ........... CALCIUM/SIGNALLING/IMMUNOSUPPRESSION..................................................................... CALCIUM/IMMUNOTOXICITY/POLYCYCUC AROMATIC HYDROCARBONS ........... CALCIUM/BERYLLIUM/ANTIBODIES........................................................................................... CALCIUM/CANCER/PEROXISOMES .............................................................................................. CALCIUM/CENTRAL NERVOUS SYSTEM/METHYLMERCURY ........................................ CALCIUM/METALLOTHIONEIN/CADMIUM INHIBITOR........................................................ CALCIUM/PHOSPHORYLATION/APOPTOSIS ............................................................................ CALCIUM/APOPTOSIS/THAPSIGARGIN....................................................................................... CALCIUM/CULTURED HEART CELLS/LOCAL ANESTHETICS .......................................... CALCIUM/MrTOCHONDRLA/DICHLOROVTNYL CSTEINE ................................................... CALCIUM/CYANIDE/ACIDOSIS ...................................................................................................... CALCIUM/PURINERGIC RECEPTORS/ATP.................................................................................. CALCIUM/ANOXIA/MITOCHONDRIA........................................................................................... CALCIUM/CAGED CALCIUM MEDIATORS/IP3.......................................................................... CALCIUM/GILLS/ALUMINUM........................................................................................................... CALCIUM AND PH/CORNEAL EPITHELIUM/RECOVERY...................................................... CALORIC RESTRICTION/CARCINOGENICITY/NUTRITION................................................. CALORIC RESTRICTION/TOXICITY STUDIES/RISK ASSESSMENT........... .................. CALORIC RESTRICTION/CHRONIC BIOASSAY/CYTOCHROME P450 ............................. CALORIC RESTRICTION/CYTOCHROME P450/DRUG METABOLISM............................. CALYCULIN A/PROTEIN PHOSPHATASE/MICROCYSUN ................................................... CAM KINASE n/DFP/CYTOSKELETAL PROTEINS ................................................................... CANCER/ESTROGEN/IGF-I RECEPTOR......................................................................................... CANCER/RISK/CHLORAMBEN......................................................................................................... CANCER/RISK/ACETAMIDE ............................................................................................................. CANCER/HEART DISEASE/ENVIRONMENTAL TOBACCO SMOKE............................... 480 880 1 p canc 88| 882 884 887 888 889 '118 1120 1189 1190 1188 878 CANC CANC CANC CANC canc cani cani CAW CARP care CARE CARE CARE 1407 CARE 1454 CARE 1497 CARE CARE CARE CARE 596 CARE CARE CARE CARE -.621 CARE ..871 CARE 903a CARE CARE .951 CARE ..952 CARE ..953 .1012 CARE CARE .1096 CARE .1187 CARE .1188 CARE .1419 CARE .1425 CARC .1475 .1490 .1491 .1492 .1495 .1497 .1655 ..983 ..932 ..934 ..935 .1174 .1094 .1359 ..457 ..539 ..541 ..719 CARC CAR( CARC CARC CARC CARC CARC CARC CARC CARC CARC CARC CARC CARC CARC CARC CARC CARC 511904 0203 CANCER/AH RECEPTOR/ANTIESTROGEN....................................................................................................................................................... 732 CANCER/PEROXISOMES/CALCIUM ................................................................................................................................................................ 1096 CANCER/CHEMOPREVENTION/CARCINOGEN............................................................................................................................................ 1388 CANCER POTENCY/STOCHASTIC MODELING/LEAD................................................................................................................................ 543 CANCER RISK/PBPK/CHLOROFORM.................................................................................................................................................................. 542 CANCER RISK/DRINKING WATER/1,3-DICHLOROPROPENE .................................................................................................................555 CANINE/QEEG/XYLAZINE............................................................................................................................................................. 1376 CANINE EXPOSURE/INHALATTON TOXICOLOGY/AEROSOL................................................................................................................. 158 CANNAB1NOID RECEPTOR/IMMUNE CELLS/DELTA9-THC................................................................................................................... 1400 CARBARYL/INHALATION/HUMORAL IMMUNITY ........................................................................................................................................15 CARBARYL/S KIN/ABSORPTION...........................................................................................................................................................................664 CARBOFURAN/METHYL PARATHION/BIOMARKERS .............................................................................................................................. 916 CARBOFURAN/METABOLISM/PESTICIDES...................................................................................................................................................1521 CARBON DIOXIDE/BLOOD GASES/MICROCAPNOMETRY ..................................................................................................................... 864 CARBON DISULFIDE/AXONOPATHY/DISULFIRAM .................................................................................................................................. 763 CARBON DISULFEDE/CYTOSKELETON/NEUROFILAMENT..................................................................................................................... 764 CARBON DISULFIDE/CROSSLINKING/NEUROFILAMENT....................................................................................................................... 765 CARBON MONOXIDE/GLUTAMATE/AUDITORY SYSTEM ................................................................................................................... 1334 CARBON TETRACHLORIDE/TISSUE REPAIR/DIBENAMINE..................................................................................................................... 40 CARBON TETRACHLORIDE/SENSmVITY ANALYSIS/PHARMACOKINETICS/TOXICOKINETICS ......................................... 74 CARBON TETRACHLORIDE/PHARMACOKINETIC MODELING/TRICHLOROETHYLENE ........................................................... 78 CARBON TETRACHLORIDE/TYROSINE/FREE RADICALS....................................................................................................................... 368 CARBON TETRACHLORIDE/GENE EXPRESSION/HYDRAZINE ............................................................................................................ 517 CARBON TETRACHLORIDE/HEPATO PROTECTION/CHOLESTEROL SUCCINATE...................................................................... 678 CARBON TETRACHLORIDE/AET AND LIVER INJURY/LIVER NECROSIS, PREVENTION ....................................................... 1049 CARBON TETRACHLORIDE/CHLOROFORM/VEHICLE............................................................................................................................ 1050 CARBON TETRACHLORIDE/POTENTIATION/HEPATOTOXICITY ...................................................................................................... 1051 CARBON TETRACHLORIDE/HEPATOTOXICITY/RAT STRAIN COMPARISON ............................................................................. 1460 CARBON TETRACHLORIDE/TISSUE REPAIR/POSTNATAL DEVELOPMENT..................................................................................1461 CARBON TETRACHLORIDE/CELL REPLICATION/HEPATOTOXICITY.............................................................................................1463 CARBON TETRACHLORIDE/METHANOL/KUPFFER CELLS .................................................................................................................1470 CARBON TETRACHLORODE/CELL REPLICATION/METHAMPHETAMINE.................................................................................... 1469 CARBONYL REDUCTASE/NITROSAMINE/PLACENTA............................................................................................................................ 1310 CARBOXYLESTERASE//N VITRO KINETICS/NASAL ...................................................................................................................................151 CARBOXYLESTERASE/PYRROLIZIDINE ALKALOID/JACOBINE........................................................................................................1299 CARBOXYLESTERASE/ESTERASE/HYDROLASE B.................................................................................................................................. 1300 CARCINOGEN/DNA STRAND BREAKS/ALKALINE ELUTION................................................................................................................ 840 CARCINOGEN/CANCER/CHEMOPREVENTION.................................................................... 1388 CARCINOGEN POTENCY/4-AMINOBIPHENYL/BENZIDINE.....................................................................................................................473 CARCINOGENESIS/GENISTEIN/CHEMOPREVENTION................................................................................................................................ 46 CARCINOGENESIS/IN VITRO/CELL PROLIFERATION ..............................................................................................................................312 . CARCINOGENESISAJVER/CELL PROLIFERATION .................................................................................................................................... 424 j CARCINOGENESIS/TEMPERATURE/MITROGENESIS................................................................................................................................ 433 CARCINOGENESIS/ESTROGEN/ANIMAL MODEL .......................................................................................................................................459 j CARCINOGENESIS/THYROID/HORMONALLY-MEDIATED.....................................................................................................................461 j CARCINOGENESIS/TUMOR DEVELOPMENT/ISOPRENE ......................................................................................................................... 469 CARCINOGENESIS/BIOMARKERS/MIXTURES............................................................................................................................................. 471 CARCINOGENESIS/NITROSAMINE/PLANARIA ........................................................................................................................................... 472 CARCINOGENESIS/P53/TUMOUR-SUPPRESSOR........................................................................................................................................... 521 CARCINOGENESIS/P-450 INDUCTION/CELL ACIDIFICATION .............................................................................................................. 677 CARCINOGENESIS/DIETARY RESTRICTION/RAT SURVIVAL .............................................................................................................. 933 CARCINOGENESIS/DICHLOROACETATE/PROTEIN KINASE................................................................................................................... 960 CARCINOGENESIS/MEDIUM-TERM LIVER/MULTI-ORGAN MODEL .................................................................................................961 CARCINOGENESIS/CELLPROLIFERATION/GENOTOXICITY/LIVER................................................................................................... 963 CARCINOGENESIS/MECHANISMS/CHLORINATED PARAFFINS ........................................................................................................ 1056 481 511904 0204 CARCINOGENESIS/HUMAN/TOXICOLOGY........................................................................................................................................... CARCINOGENESIS/SUSCEPTIBILITY/PREDISPOSITION................................................................................................................ ' ll37 CARCLNOGENESIS/ENDOMETRTUM/CULTURE............................................................................................................................... 11! CARCINOGENESIS/SIMULATION/FOCAL GROWTH....................................................................................................................... 114! CARCINOGENESIS/APOPTOSIS/CHROMIUM ........................................................................................................................................ CARCINOGENESIS/CELLPROLIFERATION/CHLOROACETIC ACIDS ....................................................................................... CARCINOGENESIS/PEROXISOMEPROLIFERATORS/WY 14,643 .................................................................................................... , , * CARCINOGENESIS/METALS/OXIDATIVE INJURY............................................................................................................................... ,,9I CARCINOGENESIS/TCDD/ONCOGENES....................................................................................................................................................' l5 ` CARCINOGENESIS/PESTICIDES/HUMAN TISSUES ............................................................................................................................... !54l CARCINOGENIC HAZARD/RISK ASSESSMENT/STRUCTURE-ACTTVITY RELATIONSHIP ANAL/ AROMATIC AMINES ............................................................................................................................................................................................453 CARCINOGENICITY/RISK ASSESSMENT/ARSENIC............................................................................................................................... 5, CARCINOGENICITY/NONSTEROIDAL ANTIINFLAMMATORY DRUG/RENAL PAPILLARY NECROSIS........................... | ^ CARCINOGENICITY/NCI/NTP BIOASSAYS/QSAR ......................................................................................................................................474 CARCINOGENICITY/METHYL TERTIARY BUTYL ETHER/RISK ASSESSMENT ............................................................................540 CARCINOGENICITY/HEPATOTOXICITY/PYRRROLIZIDINEALKALOIDS....................................................................................... 557 CARdNOGENICITY/DATABASE/PHARMACEUTICALS...........................................................................................................................795 CARCINOGENICITY/DATABASE/PHARMACEUTICALS ...........................................................................................................................799 CARCINOGENICITY/NUTRITION/CALORIC RESTRICTION....................................................................................................................937 CARCINOGENICITY/BERYLLIUM/INHALATION.......................................................................................................................................10[| CARCINOGENICITY/METABOLISM/HUMAN ............................................................................................................................................ 1139 CARCINOGENICITY/RODENT/SURVIVAL.................................................................................................................................................... 1177 CARCINOGENICITY/CHIRAL/PESTICIDES.................................................................................................................................................... 1531 CARCINOGENICITY BIOASSAY/SILICONE/MAMMARY IMPLANT.................................................................................................... 835 CARCINOGENICS/INHALATTON/FIBERS ...................................................................................................................................................... 1665 CARCINOGENS1S/PEROXISOME PROLIFERATION/CELL PROLIFERATION ................................................................................. 1166 CARDIAC MYOCYTES/ISCHEMIA/REPERFUSION/VTABIUTY ............................................................................................................. 308 CARDIAC SENSITISATION/CHLOROFLUOROCARBONS/FLUOROCARBONS...............................................................................1484 CARDIAC TOXICITY/ELECTROCARDIOGRAPHY/Q-T INTERVAL..................................................................................................... 1478 CARDIAC TOXICITY/EMETINE/GLYCOLYSIS ........................................................................................................................................... 1485 CARDIOMYOCYTES/CALCIUM/CADMIUM................................................................................................................................................... 871 CARDIOVASCULAR/DRUG/TOXICOKINETICS............................................................................................................................................ 389 CARDIOVASCULAR/HYPOVOLEMIC SHOCK/BLOOD SUBSTITUT E.................................................................................................1477 CARDIOVASCULAR/MONKEYS/RADIOTELEMETRY..............................................................................................................................1480 CARDIOVASCULAR/HYPERTENSION/PHENYLPROPANOLAMINE................................................................................................... 1488 CAROLINA RINSE/TRANSPLANTATION/GLYCINE....................................................................................................................................620 CARPET EMISSIONS TESTING/NEUROTOXICITY EVALUATION/RESTRAINT-INDUCED STRESS ......................................967 CARPETS/IRRITANT/OFFGASSING ...................................................................................................................................................................966 CARPETS/SENSORY IRRITATION/ASTM E981 ............................................................................................................................................... 969 CARPETS/SENSORY IRRITATION/NEUROTOXICITY ............................................................................................................................... 970 CARPETS/FUNCTIONAL OBSERVATIONAL BATTERY/NEUROTOXICITY ..................................................................................... 971 CARPETS/MIXTURES/IRRITATION ................................................................................................................................................................. 973a CARPETS/SENSORY IRRITATION ..................................................................................................................................................................... 973 CARRIER ERYTHROCYTES/PAROXON/ANTAGONISM ......................................................................................................................... 1537 CATALASE/GLUTATHIONEPEROXIDASE/COPPER-DEFICIENCY..................................................................................................... I486 CATALYSIS/METAL BINDING MOTIFS/ORGANOPHOSPHORUS HYDROLASE ............................................................................ 892 CATARACTOGENESIS/AH RECEPTOR/ACETAMINOPHEN .................................................................................................................... 374 CATECHOL ESTROGENS/GLUTATHIONE CONJUGATION/METHYLATION ...................................................................................657 CATECHOLAMINES/METAM SODIUM/OVULATION..................................................................................................................................214 CATECHOLAMINES/VALPROIC ACID/OVULATION..................................................................................................................................215 CATECHOLESTROGENS/PARATHION/ESTRADIOL...................................................................................................................................1523 CATFISH/FUMON1SIN Bl/SPHINGOLIPrD........................................................................................................................................................ 721 CATFISH/CHLORINATED ALICYCUCINSECTICIDES/GABA RECEPTOR ....................................................................................... 917 CATFISH/BIOMARKERS/IMMUNOSUPPRESSION .....................................................................................................................................1654 C c c c c c c c c c c c C: Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl CE Cl Cl Cl Cl Cl CE CE CE CE CE CE CE CE 511904 0205 CATS/HEINZ BODY/ACETAMINOPHEN ........................................................................................................ CATTLE/CHELATORS/LEAD 7.,.....................................................................................................................................................................tool CC14 TOXICITY INHIBITORS/INDUCERS/AP:1 TRANSCRIPTION FACTOR/ONCOGENE EXPRESSION................................ 5)5 CC14/RETINOL/LIVER............................................................................................................................................................................................. 1468 CCI4/UVER/FLUORESCENCE SPECTROSCOPY ........................................................................................................................................... 869 CDNA/TCDD/CYTOCHROME P-450 .................................................................................................................................................................. 1618 CDNA-EXPRESSION/GENOTOX1CITY/CYTOCHROME P-450.................................................................................................................. 498 CELL/BIOLOGY/BILIARY........................................................................................................................................................................................713 CELL ACIDIFICATION/CARCINOGENESIS/P-450 INDUCTION .............................................................................................................. 677 CELL ADHESION ASSAY/ENDOTHELIAL CELLS/INTERLEUKIN-1 ..................................................................................................... 311 CELL CULTURE/INDUCTION/CYTOCHROME P-450 ...................................................................................................................................129 CELL CYCLE/FERTILITY ASSAY/TOXICOLOGICAL SCREEN................................................................................................................ 208 CELLCYCLE/BIS-(2-CHLOROETHYL)-SULFIDE/KERATINOCYTES ................................................................................................... 352 CELL CYCLE/HEPG2 CELLS/BERBERINE........................................................................................................................................................ 783 CELL CYCLE/TCDD/PKC ......................................................................................................................................................................................1511 CELL CYCLE ANALYSIS/DIETARY RESTRICTION/AFLATOXIN Bi..................................................................................................... 200 CELL DEATH/RENAL PROXIMAL TUBULE/GLYCINE RECEPTOR........................................................................................................190 CELL DEATH/FATTY ACID/LIVER......................................................................................................................................................................684 CELL DEATH/LIVER/MTTOCHONDRIAL PERMEABILITY TRANSITIO .............................................................................................. 928 CELL DEATH/PHOSPHOLIPASE A2/KIDNEY................................................................................................................................................. 929 CELL DEATH/CYTOPROTECTION/RENAL PROXIMAL TUBULE ......................................................................................................... 930 CELL DEATH/NITRIC OXIDE SYNTHASE/LIVER .........................................................................................................................................931 CELL DEATH/APOPTOSIS/FLOW CYTOMETRY ......................................................................................................................................... 1160 CELL DENSITY/HUMAN LYMPHOBLASTOID CELLS/TRANSCRIPTION FACTOR KB................................................................. 449 CELL ENERGY/NMR SPECTROSCOPY/CYANIDE.......................................................................................................................................1332 CELL INJURY/CELL REGENERATION/RENAL PROXIMAL TUBULE................................................................................................... 160 CELL INJURY/PROPYLENE GLYCOL/LIPID PEROXIDATION .................................................................................................................164 CELL INJURY/OZONE/STRESS PROTEINS ...................................................................................................................................................... 624 CELL INJURY AND DEATH/EXTRACELLULAR ACIDOSIS/RENAL PROXIMAL TUBULE........................................................... 189 j CELL KILLING/ALUMINUM/HEPATOCYTES................................................................................................................................................1182 I CELL NUCLEUS/BIOSYNTHESIS/GLUTATHIONE ...................................................................................................................................... 642 I CELL PROLIFERATION/ROTENONE/TAXOL....................................................................................................................................................39 j CELL PROLIFERATION/CARCINOGENESIS/IN VITRO ............................................................................................................................. 312 j CELL PROLIFERATION/IN VITRO TESTING/TOXICITY ........................................................................................................................... 316 ! CELL PROLIFERATION/TOXICOKINETICS/CHEMICAL MIXTURES ...................................................................................................381 CELL PROLIFERATION/CHEMICAL MIXTURES/PBPK ............................................................................................................................. 398 CELL PROLIFERATION/PROTEIN SECRETION/SMOOTH MUSCLE CELLS....................................................................................... 420 CELL PROLIFERATION/HEPATOTOXICITY/PCNA...................................................................................................................................... 421 CELL PROLIFERATION/P34CDC2 KINASE/PHENOBARBITAL................................................................................................................423 CELL PROLIFERATION/CARCINOGENESIS/LIVER ....................................................................................................................................424 CELL PROLIFERATION/HUMAN PLACENTA/CADMIUM.........................................................................................................................425 ; CELL PROLIFERATION/NICOTINE/C-MYC ................................................................................................................................................... 427 j CELL PROLIFERATION/PROPIONIC ACID/FORESTOMACH .................................................................................................................. 429 ! CELL PROLIFERATION/HEPATOBILIARY FUNCTION/BILIARY EPITHELIUM.............................................................................. 431 | CELL PROLIFERATION/LABELLING INDEX/ADRENERGIC ..................................................................................................................434 ! CELL PROLIFERATION/CHLOROFORM/INHALATION............................................................................................................................. 435 j CELL PROLIFERATION/HYDROQUINONE/KIDNEY ..................................................................................................................................437 ! CELL PROLIFERATION/TOPOISOMERASES/GENE REGULATION.......................................................................................................446 i CELL PROLIFERATION/HEPATOCARCINOGENESIS/ESTRADIOL.......................................................................................................455 j CELL PROLIFERATION/NASAL CARCINOGENESIS/RISK ASSESSMENT..........................................................................................536 CELL PROLIFERATION/RESISTANCE/STYRENE .........................................................................................................................................685 CELL PROLIFERATION/TCDD/HEPATOCYTES............................................................................................................................................. 959 CELL PROLIFERATTON/FISH/P34CDC2........................................................................................................................................................... 1067 CELL PROLIFERATTON/TRHODOTHYRONINE/BILIARY EPITHELIUM.............................................................................................1092 CELL PROLIFERATION/CARCINOGENSIS/PEROXISOME PROLIFERATION ................................................................................. 1166 809 CFIJ- PROLIFERATION/CHLOROACETIC ACIDS/CARCINOGENESIS.............................................................................................. n CELL PROLIFERATION/NASALTOXICITY/HEXAMETHYPHOSPHORAMIDE............................................................................ 12lg CELL PROLIFERATION/OZONE/AGING ......................................................................................................................................................... 223 CELL PROLIFERATION/LATENCY TIME/DNA DAMAGE....................................................................................................................... l2g2 CELL PROLIFERATION/PARTIAL HEPATECTOMY/DIOXIN ................................................................................................................15,3 CELL PROLIFERATION/PHENOBARBITAL/BRDU .....................................................................................................................................I569 CELL PROLIFERATION/ONCOGENE/DIOXIN ......................................................................................................... ................................... 1624 CELL PROLIFERATTON/TCDD/RECEPTORS.................................................................................................................................................. 162j CELL PROLIFERATION/CHRYSOTILE ASBESTOS/KEVLAR ARAMID...............................................................................................I66g CELL PROLIFERATION/GENOTOXICITY/LIVER/CARCINCX3ENESIS.................................................................................................. 963 CELL REGENERATION/RENAL PROXIMAL TUBULE/CELL INJURY...................................................................................................160 CELL REPLICATION/PHENOBARBITONE/PANCREAS ............................................................................................................................. 436 CELL REPLICATION/HEPATOTOXICITY/CARBON TETRACHLORIDE............................................................................................ 1463 CELL REPLICATION/METHAMPHETAMINE/CARBON TETRACHLORODE....................................................................................1469 CELLULAR ANTIOXIDANTS/QGARETTE SMOKE/OXEDATTVE DAMAGE......................................................................................1681 CELLULAR HYPERTROPHY/METALLOTHIONEIN/MT GENE TRANSCRIPTION............................................................................ 883 CELLULAR PROLIFERATION/P34CDC2 KINASE/RATS.............................................................................................................................422 CELLULAR TOXICITY/M-BROMOPHENYL CYSTEINE/RENAL PROXIMAL TUBULE..................................................................162 CELLULAR TOXICITY/MERCURY/METAL-UGAND COMPLEXES..................................................................................................... 1013 CENTRAL NERVOUS SYSTEM/METHYLMERCURY/CALCIUM ..........................................................................................................1187 CENTRAL NERVOUS SYSTEM/METALS/MICROGLIA........... 1338 CEPHALORIDINE/NEPHROTOXICITY/DIABETES ........................ 185 CH3HG+-RESISTANT CELL LINE/GLUTATHIONE/ACCUMULATION ................................................................................................ 994 CHANNEL CATFISH/AFLATOXIN Bi/BIOTRANSFORMATION............................................................................................................ 1287 CHANNEL CATFISH/MALACHITE GREEN/DISPOSITION................................................... 1710 CHAPARRAL/HEPATOTOXICrrY/HAZARD................................................................................................................................................... 566 CHARACTERIZATION/BILIARYEPITHELIUM/HEPATOCYTES ..........................................................................................................1091 CHARACTERIZATION/BILIARY EPITHELIUM/HEPATOCYTES ..........................................................................................................1093 CHELATOR/3-HYDROXYPYRIDIN-4-ONE/BLOOD-BRAIN BARRIER.................................................................................................1000 CHELATORS/METALS/KIDNEY.............................................................. .*........................................................................................................ 184 CHELATORS/HEAVY METALS/8-OXOGUANINE ........................................................................................................................................ 999 CHELATORS/LEAD/CATTLE...............................................................................................................................................................................1001 CHELATORS/PROTOPORPHYRIA/IRON........................................................................................................................................................ 1102 CHEMICAL ALLERGENS/LYMPH NODE CELLS/INTERLEUKIN 4 ..................................................................................................... 1260 CHEMICAL CARCINOGENESIS/LONG-TERM STUDIES/MTD/MTE.......................................................................................................475 CHEMICAL INJURY/MORPHOLOGIC RESPONSE/BILIARY TREE......................................................................................................... 714 CHEMICAL KINDLING/NEUROTOXIN/PROCONVULSANT .................................................................................................................. 1340 CHEMICAL MIXTURES/CELL PROLIFERATION/TOXICOKINETICS .................................................................................................. 381 CHEMICAL MDCTURES/PBPK/CELL PROLIFERATION ............................................................................................................................. 398 CHEMICAL MIXTURES/ENVIRONMENTAL CHEMICALS/HAZARDOUS WASTE SITES .............................................................545 CHEMICAL STRESS/RENAL TRANSSPORT/HEAT SHOCK.....................................................................................................................1135 CHEMICAL/RADIATION DOSE/UNCERTAINTY ANALYSIS/MONTE CARLO SIMULATION .................................................. 1149 CHEMICALS OF CONCERN/COMPUTER PROGRAM/HAZARDOUS WASTE SITES...................................................................... 1147 CHEMICALS/RADIONUCLIDES/SCREENINGTOOL/DOSE RECONSTRUCTION ...........................................................................1148 CHEMOKINE/INFLAMMATION/TRANSGENIC.............................................................................................................................................945 CHEMOPREVENTION/DIETHYLSTILBESTROL/NEONATAL .................................................................................................................... 45 CHEMOPREVENTION/CARCINOGENESIS/GENISTEIN............................................................................................................................... 46 CHEMOPREVENTION/ANTIOXIDANT/HETEROCYCLICAMINE ......................................................................................................... 638 CHEMOPREVENTION/ANTIOXIDANT/HETEROCYCLIC AMINE ..................................................................................... 958 CHEMOPREVENTION/CARCINOGEN/CANCER................................................................................................................ 1388 CHEMOPREVENTION/RECEPTORS/RETINOIDS......................................................................................................................................... 1392 CHEMOPROTECTION/MOLECULAR MODELING/INDOLE COMPOUNDS............................................................................................44 CHEMOTACTIC FACTORS/NEUROPHILS/CYTOKINES............................................................................................................................. 250 CHICKEN/CYTOCHROME P-450/AFLATOXIN B1 .......................................................................................................................................1301 CHICKENS/ACRYLAMIDE/TOXICOKINETICS............................................................................................................................................... 385 484 511904 0207 Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl CHILD/LEAD ISOTOPES/KINETICS .............................................................................................................................................. 260 CHILDREN/IRON INTAKE/BLOOD LEAD.................................................................................................................................... 257 CHILDREN/BLOOD LEAD/DIETARY CALCIUM ......................................................................................................... 258 CHILDREN/DIETARY FAT/BLOOD LEAD.................................................................................................................................... 893 CHIRAL/PESTICIDES/CARCINOGENICITY................................................................................................................................ 1531 CHLORAMBEN/CANCER/RISK......................................................................................................................................................539 CHLORINATED ALICYCLICINSECTICIDES/GABA RECEPTOR/CATFISH ............................................................................917 CHLORINATED AZO(XY)BENZENES/TCDD/ANTIESTROGENlCITY .................................................................................... 1507 CHLORINATED COMPOUNDS/UNCERTAINTY FACTORS/REFERENCE DOSE .......................................................... 1591 CHLORINATED HYDROCARBONS/TOXICITY/COMBUSTION ..............................................................................................1648 CHLORINATED PARAFFINS/CARCINOGENESIS/MECHANISMS .......................................................................................... 1056 CHLORINE/INHALATION/NASALIRRITATION .......................................................................................................................1221 CHLOROACETIC ACIDS/CARCINOGENESIS/CELL PROLIFERATION.................................................................................. 1168 CHLOROFLUOROCARBONS/FLUOROCARBONS/CARDIAC SENSITISATION.....................................................................1484 CHLOROFORM/DOSE-RESPONSE/PBPK MODELS ...................................................................................................................... 65 CHLOROFORM/DOSIMETRY/PHARMACOKINETIC MODEL.....................................................................................................77 CHLOROFORM/RATS/INHALATION............................................................................................................................................ 178 CHLOROFORM/BLOOD CONCENTRATIONS/GAVAGE VOLUME ..........................................................................................179 CHLOROFORM/CYTOCHROME P-450 2E1/KIDNEY...................................................................................................................199 CHLOROFORM/TRICHLOROETHYLENE/INFECnON.............................................................................................................. 418 CHLOROFORM/INHALATION/CELL PROLIFERATION............................................................................................................ 435 CHLOROFORM/CANCER RISK/PBPK........................................................................................................................................... 542 CHLOROFORM/VEHICLE/CARBON TETRACHLORIDE........................................................................................................... 1050 CHLOROFORM/DOSIMETRY/TOXICOKINETICS .....................................................................................................................1054 CHLOROFORM/NEPHROTOXICITY/BROMODICHLOROMETHANE...................................................................................... 1075 CHLOROFORM/COVALENT BINDING/GLUTATHIONE........................................................................................................... 1078 CHLOROFORM/INHALATION/WHOLE BODY EXPOSURE/INHALED DOSE........................................................................ 1202 CHLOROFORM/TRICHLOROETHYLENE/MIXTURES...............................................................................................................1471 CHLOROPENTAFLUOROBENZENE/DERMALABSORPTION/TOXICOKINETICS ................................................................ 675 CHLOROPHENOLS/HEPM CELLS/DEVELOPMENTAL TOXICITY........................................................................................... 328 CHLOROSILANES/VAPOR INHALATION/HYDROGEN CHLORIDE ......................................................................................1198 CHLOROSILANES/VAPOR INHALATION/HYDROGEN CHLORIDE ......................................................................................1199 CHLOROTRIFLUOROETHENE/GLUTATHIONE CONJUGATION/HUMAN LIVER .............................................................. 1053 CHLORPROMAZINE/TOXICrrY/TCDD ......................................................................................................................................1512 CHLORPYRIFOS/ACETYCHOLINESTERASE/IN UTERO EXPOSURE..................................................................................... 910 CHLORPYRIFOS/THERMOREGULATION/ORGANOPHOSPHATES....................................................................................... 1354 CHLORPYRIFOS-OXON/ORGANOPHOSPHATE INffiBITION/ACETYLCHOLINESTERASE INHIBITION......................... 909 CHLORZOXAZONE/IMMUNOINHIBmON/CYTOCHROME P-450 ........................................................................................... 100 CHLORZOXAZONE HYDROYXLATION/CYP2E1 /CYTOCHROME P-450 2E1........................................................................ 1561 CHO CELLS/GENETIC TOXICOLOGY/CYTOGENETICS .......................................................................................................... 842 CHOLESTASIS/2,6-DI-T-BUTYL-4-NrTROPHENOL/HEPATIC...................................................................................................681 CHOLESTEROL/LIVER/MEMBRANE..........................................................................................................................................1446 CHOLESTEROL SUCCINATE/CARBON TETRACHLORIDE/HEPATO PROTECTION............................................ 678 CHOLESTEROL-CONJUGATED/CYTOCHROME P4502B1/OLIGONUCLEOTIDES................................................................ 102 CHOLESTYRAMINE/NECROSIS/BILE ACID SEQUESTERANT............................................................................................... 1090 CHOLINERGIC/ENZYME ASSAYS/PHARMACOLOGY.............................................................................................................1124 CHOLINERGIC MODIFIERS/COCAINE/LOCOMOTOR ACTIVITY........................................................................................... 299 CHOLINESTERASE INTOBITION/ISOFENPHOS METABOLISM/CYTOCHROME P-450 INDUCTION ................................. 700 CHOLINESTERASE INHIBITION/MOTOR ACTTVITY/CORRELATION ................................................................................... 912 CHOLINESTERASE INHIBITION/FUNCTIONAL BEHAVIOR/PARAOXON............................................................................ 1371 CHOLINESTERASE INHIBITORS/FUNCTIONAL OBSERVATIONAL BATTERY/NEUROTOXICITY SCREENING............906 CHOUNESTERASES/AVIAN/ORGANOPHOSPHATES .............................................................................................................. 908 CHOLINESTERASES/DOG/ELECTRORETINOGRAM ................................................................................................................ 974 CHROMIUM/REFERENCE CONCENTRATION/BENCHMARK DOSE METHOD........................................................................ 59 CHROMIUM/BIOAVAILABILITY/TOXICOKINETICS.................................................................................................................383 485 511904 0208 CHROMIUM/DISTRIBUTION/BONE..................................................................................................................................................................1{Xft CHROMIUM/ANTIOXIDANT SYSTEM/TOXICITY.......................................................................................................................................lQ05 CHROMIUM/YEAST/DNA REPAIR .................................................................................................................................................................... l006 CHROMIUM/CARCINOGENESIS/APOPTOSIS ............................................................................................................................................. 54 CHROMIUM/ADDUCTS/AMINO ACIDS........................................................................................................................................................... Ii92 CHROMIUM SALTS/OXIDATIVE STRESS/LIPID METABOLITES......................................................................................................... )004 CHROMIUM/CHROMATE/CR(VI)/P450/P450IIB/P450IIE/ETHANOL..................................................................................................... (007 CHROMOSOME 7/AH RECEPTOR/TCDD.........................................................................................................................................................103, CHROMOSOME ABERRATIONS/INTERACTION/BENZENE ..................................................................................................................... CHROMOSOME DAMAGE/ANEUPLOIDY/TAMOXIFEN ......................................................................................................................... I603 CHROMOSOME PAINTING/ANEUPLOIDY/FLUORESCENCE IN SITU HYBRIDIZATION............................................................ % CHRONIC/ACUTE PHASE/DIMETHYLNTTROSAMINE............................................................................................................................... 955 CHRONIC/LIVER/COMMERCIAL HEXANE .................................................................................................................................................. 1234 CHRONIC BIOASSAY/CYTOCHROME P450/CALORIC RESTRICTION................................................................................................935 CHRONIC LEAD/GLUTAMATE RELEASE/GABA RELEASE...................................................................................................................1128 CHRONIC TOXICITY/INHALATION/COMMERCIAL HEXANE.............................................................................................................. 1233 CHRYSOTILE/ASBESTOS FIBERS/SIZE-SELECTED.................................................................................................................................... 152 CHRYSOTILE ASBESTOS/KEVLAR ARAMID/CELL PROLIFERATION...............................................................................................1668 CIGARETTE SMOKE/EPITHELIAL INJURY/REPAIR/NEUTROPHILS .................................................................................................. 275 CIGARETTE SMOKE/LUNG CLEARANCE/NITROGEN DIOXIDE..........................................................................................................1676 CIGARETTE SMOKE/OVARIAN DNA ADDUCTS/OVARIAN AHH....................................................................................................... 1677 CIGARETTE SMOKE/INHALATION EXPOSURE/PULMONARY SURFACTANT.............................................................................1679 CIGARETTE SMOKE/OXIDAnVE DAMAGE/CELLULAR ANTIOXIDANTS...................................................................................... 1681 CIGARETTE SMOKE/MITOCHONDRIAL RESPIRATION/LUNG MITOCHONDRIA........................................................................ 1682 CIGARETTE-SMOKE-CONDENSATE/ANIMAL-MODEL/PROMOTION................................................................................................ 462 CILIA/TRACHEA/POLYSORBATES ..................................................................................................................................................................1674 CIPROFIBRATE/ANALOGUES/PEROXISOMES ........................................................................................................................................... 1097 CIPROFIBRATE/PEROXISOME PROLIFERATION/VITAMIN A..............................................................................................................1101 CIPROFIBRATE/PROTEIN CHANGES/LIVER ................................................................................................................................................1162 CISPLATIN/SPERMATOZOA/DNA ADDUCTS ...............................................................................................................................................204 CISPLATTN/METALLOTHIONEIN/CADMIUM ...............................................................................................................................................889 CISPLATIN NEPHROTOXICITY/RENAL CORTICAL SLICES/PROXIMAL TUBULE CELLS ........................................................ 183 CLARA CELL NECROSIS/1-NITRONAPHTHALENE/ALL-TRANS-RETINOL ..................................................................................... 149 CLARA CELLS/CYTOCHROME P450/ETS ........................................................................................................................................................ 115 CLARA CELLS/CYTOTOXICITY/GLUTATHIONE........................................................................................................................................ 650 CLAY/SECALONIC ACID D/BINDING .............................................................................................................................................................. 790 CLAY/CYCLOPIAZONIC ACID/BINDING ........................................................................................................................................................791 CLINICAL SKIN MILDNESS/HOUSEHOLD CLEANERS/COLORIMETRIC GRADING ................................................................. 1269 CLOFIBRATE/ESTROGENS/DEHP......................................................................................................................................................................1164 CLONE/DNA REPAIR/ALKYLATION.................................................................................................................................................................859 CLONING/CYTOCHROME P-450/PULMONARY SPECIFIC ................................................... 104 CLONING/CYTOCHROME P-450/PULMONARY SPECIFIC ...................................................................................................................... 497 CLONING/UDP-GLUCURONOSYLTRANSFERASE/ETHANOL.............................................................................................................. 1322 CLONING/AH RECEPTOR/TCDD........................................................................................................................................................................ 1620 CLORINATED PARAFFINS/SUBCHRONIC TOXICITY ..............................................................................................................................1055 CLORPHENTERMINE/MACROPHAGES/PHOSPHOLIPIDOSIS ............................................................................................................... 331 CLOTH/PERCUTANEOUS ABSORPTION/PESTICIDES............................................................................................................................... 348 CLOTH PATCH TECHNIQUES/PESTICIDES/VALIDATION .....................................................................................................................1660 CNS/CONVULSIONS/ANTIINFLAMMATORY ...............................................................................................................................................810 CNS/MERCURIC CHLORIDE/BEHAVIOR ........................................................................................................................................................993 COCAETHYLENE/HEPATOTOXICrTY/COCAINE ........................................................................................................................................ 696 COCAINE/LOCOMOTOR ACTIVITY/CHOLINERGIC MODIFIERS......................................................................................................... 299 COCAINE/95% O2/ELLAGIC ACID ..................................................................................................................................................................... 592 COCAINE/FRUCTOSE/OXIDATTVE STRESS................................................................................................................................................... 615 COCAINE/COCAETHYLENE/HEPATOTOXICITY ........................................................................................................................................ 696 486 511904 0209 co co co co co co CO CO CO CO CO CO CO CO COL COL COL COL COL COL CON CON CON CON CON COM COM COM COM COM COM COM COM CONI CON< CON. CON CON CON CON CON CON CON" CONI CONI corn CONT CONT CONT CONN COPPI COPP1 COPPI COPPI CORE COCAINE/HUMAN FETAL TISSUE/BIOTRANSFORMATION COCAINE/IMMUNOSUPPRESSION/SERUM FACTOR.......... COCAINE/IMMUNOMODULATION/LIDOCAINE................. COCAINE/NEUROENDOCRINE/LMMUNOENHANCEMENT COCAINE/IMMUNOMODULATION/ETHANOL................... COCAINE/IMMUNOSUPPRESSION/METABOLISM.............. COCAINE/FLOW CYTOMETRY/THYMOCYTE SUBPOPULATIONS ................................................................. COCAINE/DEVELOPMENTAL NEUROTOXICITY/PHOSPHOINOSinDE METABOLISM ............................... COCAINE/PROLACTIN/LYMPHOCYTES................................................................................................................ COCAINE/HEART CELL CULTURES/METABOLISM .......................................................................................... COCAINE/THIN LAYER CHROMATOGRAPHY/HIGH PRESSURE LIQUID CHROMATOGRAPHY............... COCAINE IMMUNOTOXICITY/BETA-IONONE/CYTOCHROME P-450 ............................................................. COCHLEA/HAIR CELL/REACTIVE OXYGEN SPECIES......................................................................................... COCULTURED CELLS/GAP JUNCTIONS/GROWTH INHIBITION....................................................................... COLLABORATIVE LEARNING/ENHANCED LEARNING/PROBLEM-BASED LEARNING............................... COLLAGEN/AMOSITE ASBESTOS/MESOTHELIAL CELL................................................................................... COLONOCYTES/GLUTATHIONE/OXIDATTVE INJURY....................................................................................... COLONY FORMING UNITS (CFU'S)/RESPIROMETER/PROPAGULE................................................................. COLONY SIMULATING FACTOR/INTERLEUKIN-3/CYTOTKINE ..................................................................... COLORIMETRIC GRADING/CLINICAL SKIN MILDNESS/HOUSEHOLD CLEANERS .................................... COMBINATION TOXICOLOGY/MIXTURES/INTERACTION........ ................................................................... COMBUSTION/CHLORINATED HYDROCARBONS/TOXICITY ................... .................................................. COMBUSTION/POLYCYCLIC AROMATIC HYDROCARBONS/PETROLEUM .................................................. COMMERCIAL HEXANE/CHRONIC TOXICITY/INHALATION........................................................................... COMMERCIAL HEXANE/CHRONIC/LIVER .......................................................................................................... COMPARATIVE/TRIAZOLOPYRIMIDINE SULFONAMIDE/METABOLISM...................................................... COMPARATTVE/ENNVIRONMENTAL POLICY/PRIORITIES............................................................................... COMPARATIVE/TOXICOLOGY/ARSENIC............................................................................................................. COMPARISON STUDY/SPRAGUE-DAWLEY RATS/SURVIVAL RATES ........................................................... COMPLEMENT/TRIMELLITIC ANHYDRIDE/LUNG ............................................................................................ COMPLEX MIXTURES/HALOGENATED HYDROCARBONS/POLYCYCLIC AROMATIC HYDROCARBONS COMPOST/TRINITROTOLUENE (TNT)/BIOAVAILABLE.................................................................................... COMPUTER PROGRAM/HAZARDOUS WASTE SITES/CHEMICALS OF CONCERN........................................ CONCENTRATION - LIMIT GUIDELINES/RISK ASSESSMENT/SAFETY ANALYSIS...................................... CONGENER SPECIFIC/PCBS/METHODS ............................................................................................................... I CONJUGATION/2-CHOLOROETHANOL/FATTY ACID HALOETHYL ESTER SYNTHASE ............................. CONNEXIN 43/IMMUNOCYTOCHEMISTRY/GAP JUNCTIONS........................................................................... CONNEXIN EXPRESSION/GLUCOCORTICOIDS/GAPIUNCTIONS ................................................................... I CONNEXIN43/GAPIUNCTTONS/LINDANE ..1.............. ........iY................................................................. I CONTACT ALLERGY/HUMAN MAXIMIZATION TEST/LOCAL LYMPH NODE ASSAY ................................ CONTACT DERMATTnS/MAXIMIZATION TEST/SENSITIZATION TEST......................................................... CONTACT HYPERSENSrnVTTY/VTTAMIN A DIET/LOCAL LYMPH NODE ASSAY........................................ CONTACT HYPERSENSmVTTY/ISOTHIAZOLONES/LYMPH NODE CELL PROLIFERATION....................... CONTACT HYPERSENSITTVITY/LOCAL LYMPH NODE ASSAY/ORAL MUCOSA.......................................... CONTACT SENSITIZATION/HUMANS/SKIN ....................................................................................................... CONTAMINANT TRANSPORT/RISK ASSESSMENT/EXPOSURE ASSESSMENT.............................................. CONTINUOUS/DOG/INFUSION............................................................................................................................. CONTINUOUS DOSING/TCDD/IN VITRO ............................................................................................................ CONTINUOUS INFUSION/DEVICES/SAFETY ASSESSMENT ........................................................................... CONVULSIONS/ANTIINFLAMMATORY/CNS .................................................................................................... COPPER/REACnVE OXYGEN/HYDROQUINONE.............................................................................................. COPPER/METALLOTHIONEIN/WILSON'S DISEASE........................................................................................... COPPER/NEUROTOXICITY/QUINOLINIC ACID.................................................................................................. COPPER-DEFICIENCY/CATALASE/GLUTATHIONE PEROXIDASE.................................................................. CORE BODY TEMPERATURE/ANIMAL RESTRAINT/INHALATION/NOSE ONLY EXPOSURE................... .1087 .1240 .1241 .1242 .1243 .1244 1254c .1368 .1399 .1473 .1565 .954 ..329 . .131 ..287 .1667 . .646 .1629 .1556 .1269 .1153 .1648 .1658 .1233 .1234 ..393 ..792 . .800 .1176 .1611 .1563 .1636 .1147 .1151 .1063 .1456 ..134 ..133 ..132 .1255 .1266 .1261 .1262 .1267 . .557 . .546 . .868 .1048 .1479 . .810 ..597 ..885 .1129 .1486 ..866 487 511904 0210 CORN/FUMONISIN/FOODS..................................................................................................................................................................................... CORNEAL EPITHELIAL CELLS/FLUORESCENCE RATIO IMAGING/INTRACELLULAR CALCIUM ..................................' 3 * CORNEAL EPITHELIUM/FLUORESCENCE RATIO IMAGING/INTRACELLULAR PH ............................................................... 35 CORNEAL EPITHELIUM/DELAYED TOXICITY/SURFACTANTS....................................................................................................... '9g CORNEAL EPITHELIUM/RECOVERY/CALCIUM AND PH.................................................................................................................... 98j CORNEAL THICKNESS/EYE/IRRITATION ..................................................................................................................................................... 9g4 CORNEAL THICKNESS/EYE IRRITATION/NEW METHOD...................................................................................................................... 9gJ CORRELATION/CHOLINESTERASE INHIBITION/MOTOR ACTIVITY ................................................................................................. . CORROSION/IN VITRO/HUMAN SKIN...............................................................................................................................................................345 CORROSIVITY/EPIDERMIS/DERMAL...............................................................................................................................................................340 CORROSIVITY MECHANISMS/DERMAL CORROSION/IN VITRO.........................................................................................................344 CORTICOSTEROIDS/TRANSPLANTATION/IMMUNOSUPPRESSION.................................................................................................I249 COTININE/TOBACCO SMOKE/ENZYME-LINKED IMMUNOSORBENT ASSAY.............................................................................i562 COUMARIN/ANTIMUTAGEN/AFLATOXIN B1......................................................................... 4g COVALENT/4-HYDROXYNONENAL/ALDEHYDE DEHYDROGENASE ............................................................................................ [699 COVALENT ADDUCTS/HYDROQUINONE/KIDNEY....................................................................................................................................20) COVALENT BINDING/DRUG METABOLISM/SEXUAL DIMORPHISM .............................................................................................. .93 COVALENT BINDING/HEPATOTOXICITY/REACTIVE INTEMEDIATE ..............................................................................................358 COVALENTBINDING/NEPHROTOXICITY/QUINONE-THIOETHERS .................................................................................................. 652 COVALENT BINDING/GLUTATHIONE/CHLOROFORM............................................................................................................................1078 COVALENT BINDING/ACRYLONITRILE/BIOLOGIC MARKERS..........................................................................................................1406 COVALENT BINDING/DICLOFENAC/HEPATOTOXiaTY....................................................................................................................... 1684 COVALENT BINDING/HEPATOTOXICTY/ACETAMINOPHEN.............................................................................................................. 1686 COVALENT BINDING/HEPATOTOXICITY/ACETAMINOPHEN ............................................................................................................ 1687 COVALENT BINDING/HEPATOTOXICITY/ACETAMINOPHEN ............................................................................................................ 1688 COVALENT BINDING/HEPATOTOXICITY/ACETAMINOPHEN ............................................................................................................ 1692 COVALENT BINDING/HEPATOTOXICITY/ACETAMINOPHEN ............................................................................................................ 1693 COVALENT BINDING/EPICHLOROHYDRIN/HUMAN TISSUES............................................................................................................ 1702 CRESOL/HEPATOTOXICITY/LIVER SLICES................................................................................................................................................... 362 CROSS TALK/AH RECEPTOR/ESTROGEN RECEPTOR................................................................................................................................ 112 CROSSLINKING/NEUROFILAMENT/1,2-DIETHYLBENZENE ................................................................................................................761 CROSSLINKING/NEUROFILAMENT/CARBON DISULFIDE...................................................................................................................... 765 CROSSREACnVITY/ANTIBODY/HALOTHANE .........................................................................................................................................1608 CRYOPRESERVATION/HEPATOCYTES/ALLYL ALCOHOL................................................................ 1088 CRYPRESERVATION, SLICES/HUMAN LIVER/WARFARIN METOBLISM........................................................................................... 37 CTP-450/ALDOSE REDUCTASE INHIBITOR/PRIMATE...............................................................................................................................91 CU/ZN SUPEROXIDE DISMUTASE/DINITROBENZENE/GLUTATHIONE PEROXIDASE............................................................. 1344 CULTURE/HEPATOTOXICITY/HEPATOCYTES........................................................................................................................................... 1095 CULTURE/CARCINOGENESIS/ENDOMETRIUM......................................................................................................................................... 1141 CULTURED HEART CELLS/LOCAL ANESTHETICS/CALCIUM ............................................................................................................ 1475 CULTURED HEPATOCYTES/MTTOCHONDRIA/LONG CHAIN ACYL COA ........................................................................................326 CUMENE/INHALATION/SUBCHRONIC TOXICITY.....................................................................................................................................1238 CYANIDE/ENVIRONMENTAL CONTAMINANT/MITOCHONDRIA....................................................................................................... 637 CYANIDE/VASCULAR/NITRIC OXIDE (NO)....................................................................................................................................................743 CYANIDE/THIOCYANATE/3-MERCAPTOPRYUVATE................................................................................................................................822 CYANIDE/METHEMOGLOBIN/NITRITE.......................................................................................................................................................... 825 \ CYANIDE/METABOLISM/ALLYLNTTRILE.................................................................................................................................................... 1296 CYANIDE/CELL ENERGY/NMR SPECTROSCOPY.......................................................................................................................................1332 CYANIDE/METABOTROPIC RECEPTORS/INSITOLTRISPHOSPHATE.......................................................... 1365 CYANEDE/DNA FRAGMENTATION/APOPTOSIS......................................................................................................................................... 1420 CYANIDE/ACIDOSIS/CALCIUM ........................................................................................................................................................................ 1491 CYANIDE/EXCITOTOXICITY/NEURODEGENERATION..........................................................................................................................1577 CYANIDES/MANUFACTURED GAS PLANTS/RISK ASSESSMENT ....................................................................................................... 549 ll CYANOBACTERIA/MICROCYSTIN/CYTOSKELETON................................................................................................................................287 CYANOBACTERIALALKALOID/CYLINDROSPERMOPSIN/HEPATOTOXICITY............................................................................ 786 488 511904 0211 CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY C' C" C" C' C' C' C' cr C' C' c c c c c c c c c c c c c c c c c c c c c CYANOETHYLENE OXIDE/PHARMACOKINETICS/ACRYLONITRILE................................................................................................... 76 CYCLIC AMP/LINDANE/UTERINE CONTRACTION.....................................................................................................................................225 CYCLOHEXIMIDE/APOPTOSIS/2-METHOXYETHANOL.......................................................................................................................... 1424 CYCLOPENTADEENYL MANGANESE TRIC./LUNG/GLUTATHIONE ................................................................................................. 1197 CYCLOPHOSPHAMIDE/HEMORRHAGIC CYSTITIS/ACROLEIN MERCAPTURIC ACIDS............................................................. 369 CYCLOPHOSPHAMIDE/ACROLEIN/MERCAPTURIC ACIDS..................................................................................................................... 370 CYCLOPHOSPHAMIDE/APOPTOSIS/TERATOGENESIS............................................................................................................................ 1422 CYCLOPIAZONIC ACID/BINDING/CLAY .........................................................................................................................................................791 CYCLOSPORIN/TOTAL PARENTERAL NUTRITION/NEPHROTOXICITY...........................................................................................1181 CYCLOSPORIN A/RISK ASSESSMENT/IMMUNOTOXICOLOGY ............................................................................................................ 482 CYCLOSPORIN A/PROOXIDANTS/RENAL PROXIMAL TUBULES ........................................................................................................613 CYCLOSPORIN A/LEUKOTRIENES/HEPATORENAL ....................................................................................................... 815 CYCLOSPORINE/INTERLEUKIN-6/GLOMERULONEPHRmS................................................................................................................. 1402 CYLINDROSPERMOPSIN/HEPATOTOXICITY/CYANOBACTERIALALKALOID............................................................................. 786 CYNOMOLGUS/ERG C-WAVE MEASUREMENT/RETINAL PIGMENT EPITHELIUM ....................................................................976 CYNOMOLGUS MONKEYS/L-DOPA/COMT INHIBITOR/DRUG INTERACTION............................................................................. 1367 CYP1A 1/GENE REGULATION/REPRESSOR .................................................................................................................................................... 493 CYP1A1/NEROTOXICITY/AH RECEPTOR.......................................................................................................................................................1341 CYP1A2/POLYCYCLIC AROMATIC HYDROCARBONS/INDUCTION ...................................................................................................496 CYP2B1 /2/PCBS/STRUCTURE-INDUCTION....................................................................................................................................................... Ill CYP2B1/2/PCBS/STRUCTURE-INDUCTION.......................................................................................................................................................120 CYP2E1/ALCOHOL/ETHANOL............................................................................................................................................................................. 1295 CYP2E1/ISONIAZID/CYTOCHROME P450 .......................................................................................................................................................1302 CYP2E 1/CYTOCHROME P-450 2E 1/CHLORZOXAZONE HYDROYXLATION.................................................................................... 1561 CYP2El/ACETAMINOPHEN/NEPHROTOXICrrY..........................................................................................................................................1689 CYP2K 1/RAINBOW TROUT/EMBRYO................................................................................................................................................................ 105 CYRO INDUCED TOXICITY/HUMAN LIVER SLICES/CYROPRESERVATION, SLICES................................................................ 1567 CYROPRESERVATION, SLICES/CYRO INDUCED TOXICITY/HUMAN LIVER SLICES................................................................ 1567 CYSTEINE/GLUTATHIONE/BLOOD PLASMA, HUMAN..............................................................................................................................639 CYSTEINE/A549/GLUTATHIONE ......................................................................... ,...........................................................................................643 CYSTEINE REGULATION/RAT SMALL INTESTINE/GLUCOSE .............................................................................................................. 644 CYSTEINE S-CONJUGATES/FLUOROALKENES/REACTIVE INTERMEDIATES............................................................................... 360 CYSTIC FIBROSIS/INHALATION/AMELOREDE................................................................................................................................................830 CYTOCHROME/ATHEROGENESIS/ENDOTHELIAL...................................................................................................................................1482 CYTOCHROME P-450/METABOLISM/RAT LIVER SLICES ......................................................................................................................... 28 CYTOCHROME P-450/LIVER SLICES/TAUROCHOLATE UPTAKE ..........................................................................................................30 CYTOCHROME P-450/TRICHLOROETHYLENE/PBPK MODELING..........................................................................................................67 CYTOCHROME P-450/MICROSOMES/REDUCTION .......................................................................................................................................90 CYTOCHROME P-450/ANTIBODIES/PEPTIDE ..................................................................................................................................................92 CYTOCHROME P-450/GLUTATHIONE/BENZODIAZEPINE......................................................................................................................... 94 CYTOCHROME P-450/ACETAMINOPHEN/BIOTRANSFORMATION........................................................................................................96 CYTOCHROMEP450/ALUGATOR/PHEONOBARBITAL.............................................................................................................................. 97 CYTOCHROME P-450/HUMAN/MICROSOMES.................................................................................................................................................. 98 CYTOCHROME P-450/LIVER/ERYTHROMYCIN ................................................................................................ 99 CYTOCHROMEP-450/CHLORZOXAZONEOMMUNOINHIBITION.......................................................................................................... 100 CYTOCHROME P-450/SEX-RELATED DIFFERENCES/BUTADIENE ......................................................................................................101 CYTOCHROME P-450/VOC/METABOLISM....................................................................................................................................................... 103 CYTOCHROME P-450/PULMONARY SPECIFIC/CLONING ........................................................................................................................104 CYTOCHROME P-45G/TRANSLATION/ENZYME INDUCTION ................................................................................................................. 106 CYTOCHROME P-45Q/HUMAN/DIAZEPAM .....................................................................................................................................................107 CYTOCHROME P-450/HUMAN/STABHJTY .....................................................................................................................................................110 CYTOCHROME P-450/HEPATOCYTES/SECOND MESSENGERS .............................................................................................................113 CYTOCHROME P-450/PCBS #77/EROD................................................................................................................................................................116 CYTOCHROME P-450/HYDRAZINES/DRUG METABOLISM......................................................................................................................118 CYTOCHROME P-450/ALKOXYRESORUFIN ETHERS/PLANTS...............................................................................................................122 489 511904 0212 CYTOCHROME P-450/UEPATOCYTES/INDUCnON........................................................................................................................... CYTOCHROME P-450/INbUCnON/MICE ............................................................................................................................................. It! CYTOCHROME P-450/RAINBOW TROUT/HORMONES .................................................................................................................... CYTOCHROME P-450/RAINBOW TROUT/GROWTH HORMONE...................................................................................................' , ' CYTOCHROME P-450/CELL CULTURE/INDUCTION ........................................................................................................................... '', CYTOCHROME P-450/FLUVOXAMINE/ACETAMINOPHEN ............................................................................................................. ' , ^ CYTOCHROME P-450/IN VITRO/SKIN........................................................................................................................................................ 33 CYTOCHROME P-450/HUMAN TISSUES/PAPILLOMAVIRUS.......................................................................................... ............. CYTOCHROME P-450/1NDUCERS/SMALL INTESTINE.........................................................................................................................' 49 CYTOCHROME P-450/PULMONARY SPECIFIC/CLONING ................................................................................................................'' 49? CYTOCHROME P-450/CDNA-EXPRESSION/GENOTOXICITY.............................................................................................................. 498 CYTOCHROME P-450/BREAST CANCER CELLS/ICZ .............................................................................................................................. ?28 CYTOCHROME P-450/MICRONUCLEUS/BENZO(A)PYRENE ..................................................................................................................837 CYTOCHROME P-450/COCAINEIMMUNOTOX3CITY/BETA-IONONE................................................................................................954 CYTOCHROME P-450/INHIBITION/FLAVONE............................................................................................................................................. 1036 CYTOCHROME P-450/METABOLISM/TCDD..................................................................................................................................................1047 CYTOCHROME P-45Q/HEXACHLOROBIPHENYL/PREGNANCY .........................................................................................................1%, CYTOCHROME P-450/STRESS/METABOLIC INHIBITION.......................................................................................................................1173 CYTOCHROME P-450/AFLATOXINBi/CHICKEN ......................................................................................................................................130l CYTOCHROME P-450/BIOTRANSFORMATION/HUMAN TISSUES/SUBJECTS .............................................................................. 1307 CYTOCHROME P-450/HUMAN LIVER/FATTY ACID HYDROXYLATION ........................................................................................ [309 CYTOCHROME P-450/SEX DIFFERENCE/TCDD ......................................................................................................................................... 1504 CYTOCHROME P-450/TCDD/PEROXISOME PROLIFERATION.............................................................................................................. 1510 CYTOCHROME P-450/PEROXISOME PROLIFERATION/PESTICIDES .................................................................................................1522 CYTOCHROME P-450/PARATHION/ETHANOL ........................................................................................................................................... 1524 CYTOCHROME P-450/HUMAN/TAMOXIFEN............................................................................................................................................... 1597 CYTOCHROME P-450/AH RECEPTOR/TCDD ............................................................................................................................................... 1616 CYTOCHROME P-450/CDNA/TCDD ................................................................................................................................................................. 1618 CYTOCHROME P-45Q/WILDLIFE/BIOMARKERS.........................................................................................................................................1638 CYTOCHROME P-450/PCBS/DISPOSITION......................................................................................................... 1711 CYTOCHROME P-450 1A/BIOMARKERS/AQUATIC TOXICOLOGY ..................................................................................................... 114 CYTOCHROME P-450 1 A/GLUTATHIONE TRANSFERASES/TESTICULAR METABOLISM ........................................................262 CYTOCHROME P-450 1A 1/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN/2,3,7,8-TETRACHLORODIBENZOFURAN .... 1037 CYTOCHROME P-450 2A/3A/S-METHYL N.N-DIETHYLTHIOL CARBAMATE/DISULFIRAM BIOACTTVATION............... 495 CYTOCHROME P-450 2E1/DIMETHYLSULFOXIDE/KIDNEY .................................................................................................................. 119 CYTOCHROME P-450 2E1/DICHLOROETHYLENE/CYTOCHROME P-450 INHIBITOR ................................................................. 121 CYTOCHROME P-450 2E1/OUGONUCLEOTIDES/REGULATION............................................................................................................124 CYTOCHROME P-450 2E 1/PYRIDINE/RENAL INDUCTION....................................................................................................................... 198 CYTOCHROME P-450 2E 1/KIDNEY/CHLOROFORM.................................................................................................................................... 199 CYTOCHROME P-450 2E1/BIOTRANSFORMATION/FLUORINATED ETHERS ............................................................................... 1286 CYTOCHROME P-450 2E l/MOUSE/1,1 -DICHLOROETHYLENE.............................................................................................................. 1457 CYTOCHROME P-450 2E1/CHLORZOXAZONE HYDROYXLATION/CYP2E1................................................................................... 1561 CYTOCHROME P-450 3A/DITHIOCARBAMATE METABOLISM/DISULFIRAM METABOLISM ................................................. 494 CYTOCHROME P-450 INDUCTION/MOLECULAR PROBE/LASER CONFOCAL MICROSCOPE................................................. 315 CYTOCHROME P-450 INDUCTION/CHOLINESTERASE INHIBmON/ISOFENPHOS METABOLISM ...................................... 700 CYTOCHROME P-450 INDUCTION/TOXICOKINETICS/PROSTAGLANDIN SYNTHESIS INHIBITOR...................................... 705 CYTOCHROME P-450 INDUCTION/XENOIOTICS/RAT HEPATOCYTES..............................................................................................708 CYTOCHROME P-450 INHIBITOR/CYTOCHROME P-450 2E1/DICHLOROETHYLENE ................................................................. 121 CYTOCHROME P450/ETS/CLARACELLS ........................................................................................................................................................ 1'5 CYTOCHROME P450/CALORIC RESTRICTION/CHRONIC BIOASSAY................................................................................................ 935 CYTOCHROME P45Q/DRUG METABOLISM/CALORIC RESTRICTION............................................................................................... 1174 CYTOCHROME P45Q/CYP2E1/ISONIAZID.......................................................................................................................................................1302 CYTOCHROME P450 1 A/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN/UVER SLICES ................................................................1617 CYTOCHROME P4502B l/OLIGONUCLEOTIDES/CHOLESTEROL-CONJUGATED...........................................................................102 490 511904 0213 CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY CY D/ D/ D/ D/ D/ DA DA DC DC DE DE DE DE DE DE DE DE DE CYTOCHROME P450 2B1/BIOACTIVATION/MECHANISM-BASED INACTIVATION..................................................................... .499 CYTOCHROME P4502B1/PHENOBARBITAL/MICE....................................................................................................................................... 117 CYTOGENETICS/CHO CELLS/GENETIC TOXICOLOGY ............................................................................................................................842 CYTOKINE/INTERLEUKIN-12/TOXICITY ......................................................................................................................................................... 820 CYTOKINES/AIRWAY INFLAMMATION/ENDOTOXIN..............................................................................................................................271 CYTOKINES/KERATINOCYTES/UV....................................................................................................................................................................339 CYTOKINES/GLIAL FIBRILLARY ACIDIC PROTEIN/TRIMETHYLTIN.................................................................................................505 CYTOKINES/NITRIC OXIDE SYNTHASE/GLUTATHIONE......................................................................................................................... 740 CYTOKINES/HEPATOTOXICITY/PARACETAMOL.......................................................................................................................................747 CYTOKINES/MACROPHAGES/HEPATOTOXICITY.......................................................................................................................................748 CYTOKINES/LUNG/METALLOTHIONEIN.........................................................................................................................................................749 CYTOKINES/CHEMOTACTIC FACTORS/NEUROPHILS..............................................................................................................................750 CYTOKINES/INFLAMMATION/SILICA.............................................................................................................................................................751 CYTOKINES/ETHANOL/IMMUNOSUPPRESSION.........................................................................................................................................753 CYTOKINES/SUPERINDUCTION/GENE EXPRESSION.............................................................................................................................. 1405 CYTOKINES/LYMPH NODE CELLS/SKIN SENSITIZATION ................................................................................................................... 1606 CYTOKINES/IN VITRO/ALLERGY ....................................................................................................................................................................1613 CYTOPROTECTION/RENAL PROXIMAL TUBULE/CELL DEATH ......................................................................................................... 930 CYTOPROTECTION/APOPTOSIS/ACETAMINOPHEN................................................................................................................................1155 CYTOSKELETAL PROTEINS/CAM KINASE n/DFP.................................................................................................................................... 1359 CYTOSKELETON/GLIAL CELLS/AXONAL TRANSPORT................... 3 CYTOSKELETON/NEUROFILAMENT/CARBON DISULFIDE.....................................................................................................................764 CYTOSKELETON/CYANOBACTERIA/MICROCYSTIN................................................................................................................................787 CYTOSKELETON/THIOLHOMEOSTASIS/CADMIUM ................................................................................................................................ 880 CYTOTKINE/COLONY SIMULATING FACTOR/INTERLEUKIN-3 ........................................................................................................1556 CYTOTOXICITY/TISSUE SLICES/TRICHLOROETHYLENE......................................................................................................................... 35 CYTOTOXICITY/PHENYL-2-HYDROXYETHYL CYSTEINE/RENAL PROXIMAL TUBULE ......................................................... 163 CYTOTOXICITY/SUCCINIMIDE/ISOLATED RENAL CELLS..................................................................................................................... 176 CYTOTOXICITY/NEPHROTOXICITY/IMMUNOSUPPRESSANTS............................................................................................................ 187 CYTOTOXICITY/HEPATOCYTES/AZOLE ANTTFUNGALS .......................................................................................................................325 CYTOTOXICITY/SKIN KERATINOCYTES/SURFACTANTS.......................................................................................................................354 CYTOTOXICITY/ONCOGENES/MYCOTOXIN ............................................................................................................................................... 516 CYTOTOXICITY/GLUTATHIONE/CLARACELLS.........................................................................................................................................650 CYTOTOXICITY/FLUORESCENCE PROBES/LASER CYTOMETRY....................................................................................................... 778 CYTOTOXICITY/CADMIUM/MACROPHAGES............................................................................................................................................... 876 ! CYTOTOXICITY/MANGANESE/L-DOPA...................................................................................................................... 1131 CYTOTOXICITY ASSAY/TUMOR NECROSIS FACTOR/PROPIDIUM IODIDE ..............................................'.................................. 406 DAPOXETTNE/KIDNEY/METABOLISM............................................................................................................................................................. 192 DAPSONE/HEMOLYTTC ANEMIA/ERYTHROCYTE .................................................................................................................................... 361 DATA QUALITY OBJECTIVES/RISK BASED CRITERIA/RISK ASSESSMENT................................................................................... 544 DATABASE/DOSE-RESPONSE...............................................................................................................................................................................535 , DATABASE/PHARMACEUTICALS/REGULATORY..................................................................................................................................... 797 i DATABASE/PHARMACEUTICALS/CARCINOGENICITY..........................................................................................................................798 | DATABASE/PHARMACEUTICALS/CARCINOGENICITY.......................................................................................................................... 799 i DCB/UTERINE CONTRACTION/PARTURITION............................................................................................................................................226 I DCVC/b-LYASE/BIOTRANSFORMATION........................................................................................................................................................196 I DDS/PLASTICS/PHYSIOLOGIC-PHARMACOKINETICMODEL ............................................................................................................... 79 | DEET/ALPHA 2U-GLOBULIN/KIDNEY LESIONS.......................................................................................................................................... 175 ' DEET/DERMAL ABSORPTION/HUMAN VOLUNTEERS............................................................................................................................ 665 DEET/PHARMACOKINETICS/RATS..................................................................................................................................................................1717 DEF DEFOLIANT/ORGANOPHOSPHATE/PIPERONYL BUTOXIDE ......................................................................................................1520 DEGENERATION/TRIPHENYL PHOSPHITE/VISUAL SYSTEM...............................................................................................................1339 DEGRADATION RATE/REMEDIATION/RISK ASSESSMENT ...................................................................................................................548 DEHP/CLOFIBRATE/ESTROGENS.......................................................................................................................................................................1164 DEHYDROEPIANDROSTERONE/PEROXISOME PROLIFERATION/TROUT...................................................................................... 1171 491 511004 0214 DEHYDROGENASES/TARGETS/NEPHROTOXICITY.............................................................................. DELAYED OVULATION/THIRAM/PREGNANCY....................................................................................... DELAYED TOXICITY/SURFACTANTS/CORNEAL EPITHELIUM........................................................ DELETIONS/NONMUTAGENIC CARCINOGENS/DNA RECOMBINATION...................................... DELTA9-THC/CANNABINOID receptor/immune cells................................................................. DEMYELINATION/2' ,3'-DIDEOXYINOSINE/PERJPHERAL NEUROPATHY.................................... DENTIFRICE/INHIBITION/HYDROXYLRADICAL ................................................................................... DERMAL/CORROSIVITY/EPIDERMIS ........................................................................................................... DERMAL/TOXICITY/IN VITRO......................................................................................................................... DERMAL/PERMEABILITY/PHARMACOKINETICS ................................................................................... DERMAL/JACKETS/TOXICITY PARAMETERS ......................................................................................... DERMAL ABSORPTION/HUMAN VOLUNTEERS/DEET.......................................................................... DERMALABSORPTION/TOXICOKINETICS/CHLOROPENTAFLUOROBENZENE ...................... DERMAL ABSORPTION/VOLATILE/HCB .................................................................................................... DERMAL ABSORPTION/SILICONE/DISPOSITION..................................................................................... DERMAL BIOAVAILABILITY/SOIL/TRICHLOROETHYLENE............................................................... DERMAL CORROSION/IN VITRO/CORROSIVITY MECHANISMS...................................................... DERMAL DISTRIBUTION/VEHICLE EFFECTS/LINDANE ..................................................................... DERMATOTOXICITY/IN VTTRO/SULFUR MUSTARD.............................................................................. DERMATOTOXICITY/PRIMARY CULTURES/SURFACTANTS............................................................. DERMATOTOXICOLOGY/PHOTOTOXICrrY/IN VITRO............................... .......................................... DETOXIFICATION ENZYME/INDUCTIONS/DEET..................................................................................... DETOXIFICATION ENZYMES/INDUCTION/DIET..................................................................................... DEVELOPMENT/POLYOXYETHYLENE SORBITAN MONOLAURATE/POLYOXYETHYLENE SORBITAN MONOOLEATE............................................................................................................................. DEVELOPMENTAL/SILOXANE/INHALATION........................................................................................... DEVELOPMENTAL/NEUROTOXICITY/1,1,1 -TRICHLOROETHANE.................................................... DEVELOPMENTAL/NEUROCHEMISTRY/ORGANOPHOSPHORUS.................................................... DEVELOPMENTAL EXPOSURE/SOMATOSENSORY FUNCTION/METHYLMERCURY.............. DEVELOPMENTAL NEUROTOXICITY/PHOSPHOINOSnTDE METABOLISM/COCAINE ......... DEVELOPMENTAL NEUROTOXICITY/METHOD VALIDATION/POSITTVE CONTROL STUDY DEVELOPMENTAL TOXICITY/DOSE-RESPONSE MODEL/METHYLMERCURY ......................... DEVELOPMENTAL TOXICITY/CHLOROPHENOLS/HEPM CELLS...................................................... DEVELOPMENTAL TOXICITY/MNRGP12Q/VACCINE............................................................................ DEVELOPMENTAL TOXICITY/METALLOTHIONEIN/URETHANE .................................................... DEVELOPMENTAL TOXICITY/LIPID COMPLEX/AMPHOCILTM.......................................................... DEVELOPMENTAL TOXICITY/LITHIUM/TERATOLOGY ..................................................................... DEVELOPMENTAL TOXICITY/LITHIUM/LITHIUM PERFLOUROOCTANE SULFANATE......... DEVELOPMENTAL TOXICITY/TOXiaTY/PICLORAM .......................................................................... DEVELOPMENTAL TOXICITY/TOXICITY/2,4-D....................................................................................... DEVELOPMENTAL TOXICITY/PHOTOVOLTAIC MATERIALS/REPRODUCTIVE TOXICITY . DEVELOPMENTAL TOXICITY/NEUROTOXICnY/SOLVENTS............................................................. DEVELOPMENTAL TOXICITY/INTER-LABORATORY VALIDATION/FETAX ............................. DEVELOPMENTALTOXICITY/N-NITROSO COMPOUNDS/DIFFERENTIATION ......................... DEVELOPMENTAL TOXICITY/SCREENING TEST/DRUSOPHILA BIOASSAY ............................. DEVELOPMENTAL TOXICITY/HEMATOLOGIC TOXICITY/PHOTOVOLTAIC METALS ......... DEVELOPMENTAL TOXICITY/PHOTOVOLTAIC METALS/REPRODUCTIVE TOXICITY......... DEVELOPMENTAL TOXICOLOGY/RISK ASSESSMENT/MACHINE LEARNING ......................... DEVICES/SAFETY ASSESSMENT/CONTINUOUS INFUSION ............................................................... DEXAMETHASONE/IMMUNOTOXICITY/RISK ASSESSMENT............................................................ DFMO/PIROXICAM/DIFLUOROMETHYLORNITHINE............................................................................ DFP/CYTOSKELETAL PROTEINS/CAM KINASE 0 ................................................................................... DI-(2-ETHYLHEXYL)ADIPATE/PEROXISOMEPROLIFERATION/LIVER........................................ DIABETES/CEPHALORIDINE/NEPHROTOXICITY ................................................................................... DIABETES/DRUG METABOLISM/SULFOTRANSFERASE..................................................................... 492 1695 216 982 853 1400 524 .602 340 350 .668 .674 665 .675 1528 1720 .673 .344 .338 .334 .351 .333 ...50 ...49 .582 .572 .584 1542 .991 1368 1377 ..61 .328 .527 .568 .573 .577 .578 ..579 ..580 ..581 ..583 ..590 ..591 ..594 .1019 .1020 .1145 .1479 .1583 ..811 .1359 ..957 ..185 .1324 DLAD pIAG pIAJv PLAT PIAZ PIBE DIBE PICH PICH PICH DICH PICH DICH DICH DICH DICH DICH DICH DICH DICK DICH DICL< DICL< DIDE< DEDEi DIDE< DIDEi DIELI DIELI DIET/ DIET/ DIET/ DIET/ DIET/ DIET/ DIET/ DIET. DIET diet: DIET! DIET! DIET] DIETI DIFFE DIFFE DIFFE DIFFE DIFFE DIFLl DIHAJ DILTI DIME DIME DIME DIME DIADENOSINE TETRAPHOSPHATE/PCi 2 CELLS/2'CH3-MPTP........................................................................................................................ 1337 DIAGNOSTIC IMAGING/GADOLINIUM/ACUTE TOXICITY......... ................................................................................. .. .1023 DIAMIDE/FIBEROPTIC SENSOR-S/EMBRYONIC PH.....................................................................................................................................595 DIATOMS/SILICA/IN VITRO-.:........................ 142 DIAZEPAM/CYTOCHROME P-450/HUMAN .....................................................................................................................................................107 DIBENAMINE/CARBON TETRACHLORIDE/TISSUE REPAIR.....................................................................................................................40 DIBENZO[A, 1JPYRENE/DNA-BINDING/DIOL EPOXIDE ........................................................................................................................... 838 DICHLOBENIL/OLFACTORY FUNCTION/IDPN............................................................................................................................................. 297 DICHLOROACETATE/PROTEIN KINASE/CARCINOGENESIS.................................................................................................................. 960 DICHLOROACETATE/METABOLISM/TRICHOLORETHYLENE............................................................................................................ 1081 DICHLOROACETATE (DCAyPHARMACOKINETICS/TRICHLOROACETATE (TCA)...................................................................... 382 DICHLOROBENZENE/INTERACTTVE/HEPATOTOXICITY......................................................................................................................... 701 DICHLOROBENZENE/KUPFFER CELLS/SUPEROXIDE ............................................................................................................................ 1467 DICHLOROETHYLENE/CYTOCHROME P-150 INHIBITOR/CYTOCHROME P-150 2E1 .................................................................. 121 DICHLOROETHYLENE/BILE/TRANSPORTERS............................................................................................................................................. 680 DICHLOROETHYLENE/GLTATHIONE/EPOXIDE .......................................................................................................................................1052 DICHLOROFLUOROSCEIN/TOXICODYNAMICS/REDOX CYCLING.....................................................................................................625 DICHLOROMETHANE/DNA-PROTEINCROSS-LINKS/HEPATOCYTES .............................................................................................. 324 DICHLOROMETHANE/ENZYME INfflBmON/PBPK.................................................................................................................................... 376 DICHLOROVINYL CSTEINE/CALCIUM/MITOCHONDRIA ..................................................................................................................... 1490 DICHLORVTNYLCYSTEINE/TRICHLOROETHYLENE/SPECIES COMPARISON .............................................................................1085 DICLOFENAC/HEPATOTOXICITY/COVALENTBINDING.............. ..................................................................................................... 1684 DICLOFENAC/PROTEIN ADDUCTS/LIVER.................................................................................................................................................... 1685 DIDEOXYCYTIDINE/FETAL/DIDEOXYINOSINE......................................................................................................................................... 1721 DIDEOXYINOSINE/BIOAVAILABILITY/STOMACH PH............................................................................................................................. 379 DIDEOXYINOSINE/ANTI-HIV/PLACENTA...................................................................................................................................................... 525 DIDEOXYINOSINE/DIDEOXYCYTIDINE/FETAL......................................................................................................................................... 1721 DIELDRIN/DISPOSmON/7,12-DIMETHYLBENZ[A]ANTHRACENE .....................................................................................................710 | DIELDRIN/GABA-ACTIVATED CHANNEL/GABA RECEPTOR SUBUNITS ....................................................................................... 918 j DIET/DETOXIFICATION ENZYMES/INDUCTION .......................................................................................................................................... 49 S DIET/DETOXIFICATION ENZYME/INDUCTIONS .......................................................................................................................................... 50 I DIETARY CALCIUM/CHILDREN/BLOOD LEAD .......................................................................................................................................... 258 . DIETARY FAT/BLOOD LEAD/CHILDREN........................................................................................................................................................893 ! DIETARY LIPIDS/HEPATOTOXICITY/HAMSTER ........................................................................................................................................ 694 : DIETARY PROTEIN/FC AND FEEDER DESIGN/RAT LONGEVITY....................................................................................................... 1179 ! DIETARY RESTRICTION/AFLATOXIN Bi/CELL CYCLE ANALYSIS.....................................................................................................200 DIETARY RESTRICTION/RAT SURVTVAL/CARCINOGENESIS ............................................................................................................. 933 DIETARY SUPPLEMENTS/GERMANIUM TOXICITY/RENAL DYSFUNCTION .................................................................................565 DIETHYL/DIMETHYL-PHTHALATE/PEROXISOMEPROLIFERATORS/INmATION/PROMOTION ....................................... 1170 DIETHYLSTILBESTROL/NEONATAL/CHEMOPREVENTION.................................................................................................................... 45 DIETHYLSTILBESTROL/GAMETOGENESIS/MEIOSIS............................................................................................................................... 210 DIETHYLSTILBESTROL/ESTRADIOL/TUBULIN.......................................................................................................................................... 458 DIETHYLSTILBESTROUMTDNAAjENOTOXICITY .................................................................................................................................. 1271 DIFFERENTIATION/BIS-(2-CHLOROETHYL)SULFIDE/ICERATINOCYTES........................................................................................353 DIFFERENTIATION/TISSUE SPECIFICITY/GENE EXPRESSION..............................................................................................................439 DIFFERENTIATION/DEVELOPMENTAL TOXICTTY/N-NITROSO COMPOUNDS ............................................................................ 591 DIFFERENTIATION/ORGANOPHOSPHATES/MACROPHAGE/HL-60................................................................................................... 1254 DIFFERENTIATION/TCDD/OSTEOBLAST...................................................................................................................................................... 1508 DIFLUOROMETHYLORNITHINE/DFMO/PIROXICAM................................................................................................................................811 DIHALOKETENES/19F-NMR-DETECTION/DNA ADDUCTS .................................................................................................................... 373 DILTIAZEM/GLUTAMATE/EXCITOTOXICITY..............................................................................................................................................1109 DIMETHYL SULFATE/DNA ADDUCTS/UPPER RESPIRATORY TRACT.............................................................................................1216 DIMETHYLBENZ(A)ANTHRACENE/ETHANOL-INDUCED PROMOTION/PHOSPHOLIPIDS & CHOLESTEROL ................ 468 DIMETHYLNITROSAMINE/INFLAMMATION/METALLOTHIONEIN ...................................................................................................443 DIMETHYLNITROSAMINE/CHRONIC/ACUTE PHASE................................................................................................................................955 493 511904 0216 DIMETHYLNTTROSAMINE/SPLEEN/DNA DAMAGE ................................................................................................................................ ,2^ DIMETHYLSELENIDE/SELENIUM METABOLISM/FLAVIN-CONTAINING MONOOXYGENASE....................................... 3^ DIMETHYLSULFOXIDE/KIDNEY/CYTOCHROME P-450 2E1 ............................................................................................................ .",,9 DINITROBENZENE/ADDUCTS/HEMGLOBIN............................................................................................. 32[ DINITROBENZENE/AUDITORYPATHWAY/LESIONS .............................................................................................................................. I342 DINITROBENZENE/ENCEPHALOPATHY/ANTIOXIDANT....................................................................................................................... 1342 DINITROBENZENE/GLUTATHIONE PEROXIDASE/CU/ZN SUPEROXIDE DISMUTASE............................................................. 1344 DIOL EPOXIDE/DIBENZO[A, 1JPYRENE/DNA-BINDING ........................................................................................................................... 83g DIOXIN/RECEPTORS/INVERTEBRATE........................................................................................................................................................... 1027 DIOXIN/AH-RECEPTOR/ARNT ...........................................................................................................................................................................1033 DIOXIN/CELL PROLIFERATION/PARTIAL HEPATECTOMY ................................................................................................................15,3 DIOXIN/CELL PROLIFERATION/ONCOGENE .............................................................................................................................................1624 DIOXIN/SLUDGE/RECLAMATION.................................................................................................................................................................... I642 DIQUAT/ACETAMINOPHEN/OXIDANT STRESS...........................................................................................................................................607 DIQUAT/MECHANISMS/PROTEIN OXIDATION ...........................................................................................................................................610 DISPOSITION/METABOLISM/PHARMACOKINETICS....................................................................................................................................82 DISPOSITION/7,12-DIMETHYLBENZ[A]ANTHRACENE/DIELDRIN .................................................................................................... 710 DISPOSITION/PESTICIDE/ORGANOPHOSPHATES.....................................................................................................................................1529 DISPOSmON/ACRYLIC ACID/TOXICOKINETICS .....................................................................................................................................1704 DISPOSITION/ACRYLIC ACID/TOXICOKINETICS .....................................................................................................................................1705 DISPOSITION/CHANNEL CATFISH/MALACHITE GREEN....................................................................................................................... 1710 DISPOSITION/CYTOCHROME P-450/PCBS .................................. 1711 DISPOSITION/INHALATION/FIBROSIS........................................................................................................................................................... 1716 DISPOSITIONS-! 14cl ACRYLONTTRITE/SPECIES DIFFERENCE .......................................................................................................... 1719 DISPOSITION/DERMAL ABSORPTION/SILICONE....................................................................................................................................... 1720 DISPOSITION/BENZYLTRIMETHYLAMMONIUMCHLORIDE/METABOLISM............................................................................... 1722 DISRUPTED PUBERTAL GROWTH/LEAD/REPRODUCTIVE TOXICITY.............................................................................................. 256 DISTRIBUTION/BONE/CHROMIUM.................................................................................................................................................................. 1003 DISTRffiUnON/TCDD/HUMAN BLOOD .........................................................................................................................................................1044 DISTREBUTION/BIOMARKERS/METHYLENEDIPHENYL DHSOCYNATE (MDI) ...........................................................................1410 DISTRIBUTION/MICE/MUCONALDEHYDE .............................................. 1723 DISULFIRAM/CARBON DISULFIDE/AXONOPATHY .................................................................................................................................. 763 DISULFIRAM BIOACTIVATION/CYTOCHROME P-450 2A/3A/S-METHYL N.N-DIETHYLTHIOL CARBAMATE................495 DISULFIRAM METABOLISM/CYTOCHROME P-450 3A/DITHIOCARBAMATE METABOLISM................................................. 494 DITHIOCARBAMATE METABOLISM/DISULFIRAM METABOLISM/CYTOCHROME P-450 3A................................................. 494 DMP 728/BLEEDING TIME/GP HB/IIIA............................................................................................................................................................... 817 DMPS/URINARY PORPHYRINS/MERCURY ................................................................................................................................................... 998 DMSA/LEAD/NEOMYCIN......................................................................................................................................................................................1002 DNA ADDUCT/0-XYLENE/BENZO(A)PYRENE........................................................................................................................................... 1293 DNA ADDUCT DOSIMETRY/ACCELERATOR MASS SPECTROMETRY/LOW-DOSE PHARACOKINETICS ........................... 11 DNA ADDUCT FORMATION/TRIPHENYLETHYLENE DRUGS/HEPATOCARdNOGENICITY ................................................1599 DNA ADDUCTS/CISPLATIN/SPERMATOZOA ............................................................................................................................................... 204 DNA ADDUCTS/DIHALOKETENES/19F-NMR-DETECTION .....................................................................................................................373 DNA ADDUCTS/BUTADIENE/BUTADIENE MONOXIDE........................................................................................................................... 854 DNA ADDUCTS/PCR/SEQUENCING....................................................................................................................................................................858 DNA ADDUCTS/VINYL FLUORIDE/ETHENOGUANINE............................................................................................................................ 1080 DNA ADDUCTS/UPPER RESPIRATORY TRACT/DIMETHYL SULFATE.............................................................................................1216 DNA ADDUCTS/PREGNANCY/AH LOCUS .....................................................................................................................................................1281 DNA ADDUCTS/1,2,3-TRICHLOROPROPANE/HALOGENATED HYDROCARBONS.................................................................... 1283 DNA ADDUCTS/7H-DIBENZO(C,G)CARBAZOLE/32P-POSTLABELING ................................................................................ 1284 DNA ADDUCTS/HUMAN BIOMONTTORING/32P-POSTLABELING......................................................................................................1417 DNA ALKYLATION/OXIDATIVE STRESS/MELPHALAN........................................................................................................................... 635 DNA BINDING/TCDD/AH RECEPTOR ..............................................................................................................................................................1026 DNA BINDING/METABOLISM OF BAP-COATED PARTICLE/PULMONARY ALVEOLAR MACROPHAGE..........................1316 DNA DAMAGE/SINGLE CELL GEL/IN VIVO TOXICOLOGY.........................................................................................................................9 DNA dna DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DNA DOG DOG DOG DOG DOG DOM DOM DOM DOM DOP/ DOP/ DOP/ DOP. DOP. DOP DOP. DOS I DOS I DOS I DOSI DOSI DOSI DOSI DOSI DOSI DOSI DOSI DOSI DOSI DOSI DOSI DOSI DNA DAMAGE/PROLIFERATION/ACETAMINOPHEN................................................................................................................................ 430 DNA DAMAGE/MOUSE LIVER/METHYLENE CHLORIDE........................................................................................................................1074 DNA DAMAGE/DIMETHYLNITROSAMINE/SPLEEN ................................................................................................................................ 1280 DNA DAMAGE/CELL PROLIFERATION/LATENCY TIME........................................................................................................................1282 DNA DEAMINATION/BUTYL NTTRITE/NITRITE........................................................................................................................................... 856 DNA FRAGMENTATION/APOPTOSIS/CYANIDE......................................................................................................................................... 1420 DNA FRAGMENTS/APOPTOSIS/THYMOCYTES ......................................................................................................................................... 1161 DNA METHYLATION/HA-RAS/MOUSE LIVER ............................................................................................................................................. 514 DNA MODIFICATION/PHOTO-CHEMICAL MAPPING/LMPCR........................................................................................................ .857 DNA NICKING/HYDROXYL RADICAL/OXIDATIVE DAMAGE .............................................................................................................. 604 DNA RECOMBINATION/DELETTONS/NONMUTAGENIC CARCINOGENS.......................................................................................... 853 DNAREPAIR/GENOTOXICITY/MUTATION...................................................................................................................................... 850 DNA REPAIR/ALKYLATION/CLONE ................................................................................................................................................................. 859 1 DNA REPAIR/CHROMIUM/YEAST.................................................................................................................................................................... 1006 DNA REPAIR/GENOTOXICITY/TRIHALOMETHANES.............................................................................................................................. 1279 DNA REPAIR INHIBITORS/ACETAMINOPHEN/HEPATOCYTES ..........................................................................................................1285 DNA STRAND BREAKS/ALKALINE ELUTION/CARCINOGEN................................................................................................................840 DNA STRAND BREAKS/ASBESTOS/FREE RADICALS............................................................................................................................... 855 DNA STRAND BREAKS/SELENIUM/ACTIVE OXYGEN........................................................................................................................... 1009 DNA SYNTHESIS/HEPATOCYTES/POLYCYCLIC AROMATIC HYDROCARBONS........................................................................ 1029 DNA-BINDING/DIOLEPOXIDE/DIBENZO[A, 1JPYRENE ........................................................................................................................... 838 DNA-PROTEINCROSS-UNKS/HEPATOCYTES/DICHLOROMETHANE .............................................................................................. 324 DNA-PROTEINCROSSLINKS/HEXAMETHYLPHOSPHORAMIDE/FORMALDEHYDE................................................................. 1217 DOG/BODYWEIGHT/INFUSION............................................................................................................................................................................ 867 DOG/INFUSION/CONTINUOUS............................................................................................................................................................................ 868 DOG/ELECTRORETINOGRAM/CHOLINESTERASES ..................................................................................................................................974 DOG/PORPHYRIA/LIVER ......................................................................................................................................................................................1104 DOGHEPATOCYTE/FERROCHELATASE/PORPHYRIN ............................................................................................................................. 703 DOMINANT LETHAL/ACRYLAMIDE/GLUTATHIONE............................................................................................................................... 202 1 DOMOIC ACID/TOXICOKINETICS/NEUROTOXICITY............................................................................................................................... 386 i DOMOIC ACID/NEUROPATHOLOGY/NOVEL FLUORESCENT METHOD ......................................................................................... 510 DOMOIC ACID/AMNESIAC SHELLFISH POISONING/GLUTAMATE.....................................................................................................564 DOPAMINE/RELEASE/CADMIUM ................................................................................................................................................................... 1120 DOPAMINE/LEAD/BRAIN..................................................................................................................................................................................... 1127 DOPAMINE/DOPAMINE UPTAKE CARRIER/ZINC .................................................................................................................................... 1130 ' DOPAMINE/MDMA/NEUROTOXICITY .......................................................................................................................................................... 1351 DOPAMINE ANTAGON1ST/LEUKOCYTES/IMMUNOTOXICITY ...................................... 1248 DOPAMINE UPTAKE CARRIER/ZINC/DOPAMINE .................................................................................................................................... 1130 DOPAMINE/GFAP/AGE-RELATED CHANGES/METHAMPHETAMINE NEUROTOXICITY.........................................................1333 DOSE DISTRIBUTION PATTERN/METHOD VALIDATION/INTRANASAL DOSING........................................................................ 156 DOSE RECONSTRUCTION/CHEMICALS/RADIONUCLIDES/SCREENING TOOL .......................................................................... 1148 DOSE-DEPENDENTHEPATOTOXICITY/CAFFEINE/HEPATOCYTES .................................................................................................. 697 \ DOSE-EFFECT/OZONE/EXTRAPOLATION....................................................................................................................................................1222 ; DOSE-RESPONSE/PBPKMODELS/CHLOROFORM........................................................................................................................................ 65 . DOSE-RESPONSE/SKIN TUMOR/LATENCY TIME........................................................................................................................................ 465 | DOSE-RESPONSE/STOCHASTIC/MODEL...................................................................................................................................................... 1143 DOSE-RESPONSE/RISK ASSESSMENT/U-SHAPED.................................................................................................................................... 1427 j DOSE-RESPONSE/RISK ASSESSMENT/TTSSUE REPAIR ......................................................................................................................... 1432 DOSE-RESPONSE/TCDD/RISK ASSESSMENT ..............................................................................................................................................1516 DOSE-RESPONSE/TCDD/RISK ASSESSMENT ............................................................................................................................................. 1517 DOSE-RESPONSE/SUBCHRONIC/BENCHMARKDOSE ............................................................................................................................1588 DOSE-RESPONSE MODEL/METHYLMERCURY/DEVELOPMENTAL TOXICITY ............................................................................... 61 DOSED FEED/LIVER TOXICITY/BENZOPHENONE.......................................................................................................................................829 DOSIMETRY/PHARMACOKINETIC MODEL/CHLOROFORM..................................................................................................................... 77 DOSIMETRY/TOXICOKINETICS/CHLOROFORM ....................................................................................................................................... 1054 DOSIMETRY/MODELING/RISK ASSESSMENT ..................................................................................... DOWN REGULATION/TCDD/EGF RECEPTOR....................................................................................... DOXORUBICIN/CALCIUM/MITOCHONDRIA......................................................................................... DOXORUBICIN/LIPOSOME/TOXICITY.................................................................................................... DOXORUBICm/LIPOSOME/PHARMACOKINETICS/DISPOSmON............................................... DRAIZE/IN VITRO/EYE.................................................................................................................................... DRAIZE/EYE/IN VITRO.................................................................................................................................... DRINKING WATER/1.3-DICHLOROPROPENE/CANCER RISK ........................................................ DRUG/TOXICOKINETICS/CARDIOVASCULAR..................................................................................... DRUG DEVELOPMENT/MUTAGENIC ASSESSMENT/RISK ASSESSMENT ............................... DRUG INTERACTION/CYNOMOLGUS MONKEYS/L-DOPA/COMT INHIBITOR...................... DRUG METABOLISM/SEXUAL DIMORPHISM/COVALENT BINDING........................................ DRUG METABOLISM/CYTOCHROME P-450/HYDRAZINES............................................................ DRUG METABOLISM/CALORIC RESTRICTION/CYTOCHROME P450 ........................................ DRUG METABOLISM/SULFATION/SULFOTRANSFERASE............................................................... DRUG METABOUSM/SULFOTRANSFERASE/DIABETES ................................................................. DRUG METABOLIZING ENZYMES/MUNITION CHEMICAL/TETRYL .......................................... DRUG METABOLIZING ENZYMES/MUNITION CHEMICALS/TRINITROBENZENE .............. DRUG RESISTANCE/GAP JUNCTIONS/OCTANOL .............................................................................. DRUGS/GENOTOXICITY/TAMOXIFEN.................................................................................................... DRUSOPHILA BIOASSAY/DEVELOPMENTAL TOXICITY/SCREENING TEST......................... DT-DIAPHORASE/QUINONE OXIDOREDUCTASE/ENDOTHELIUM............................................. DTP VACCINE/BIOACTTVATION/ACETAMINOPHEN ....................................................................... DUST/TNF (TUMOR NECROSIS FACTOR)/TOXIC ALVEOLITIS...................................................... DUSTMITE/IGE/NO2 ........................................................................................................................................ DUSTS/IN VITRO ASSAYS/PULMONARY.......................................... ..................................................... DYE-TRANSFER ASSAY/GAP JUNCTIONS/PYRETHROID INSECTICIDES ............................... DYES/RNA/OXIDATTVE DAMAGE............................................................................................................... DYSMORPHOGENESIS/TERATOGENESIS/AVIAN................................................................................ E-LYSINE ACYLASE/HALOTHANE/PROTEIN ADDUCTS (TFA ADDUCTS) ............................. EARLY GENE EXPRESSION/TISSUE REPAIR/APOPTOSIS ................................................................ EARTHWORM/GENOTOXICITY/BIOMARKERS .................................................................................... ECETOC CHEMICALS/EYE IRRITATION/IN VITRO .............................................................................. EDUCATION/RECRUITMENT/HIGH SCHOOL ......................................................................................... EDUCATION/RISK ASSESSMENT/ENVIRONMENT ........................................ ................................... EDUCATION/TEACHING/PERFORMANCE ENHANCEMENT/IMPROVED GRADES .............. EGF RECEPTOR/MECHANISTIC MODELING/TCDD DOSIMETRY ............................................... EGF RECEPTOR/DOWN REGULATION/TCDD ....................................................................................... EGF RECEPTOR/HCG/BENZO(A)PYRENE................................................................................................ EICOSANOID/LEAD/MACROPHAGES...................................................................................................... ELASTIN/AMINE OXIDASE/AORTA........................................................................................................... ELECTROCARDIOGRAPHY/Q-T ENTERSVAL/CARDIAC TOXICITY............................................... ELECTRON MICROSCOPY/SINUSOIDAL CELLS/LIVER TRANSPLANTATION....................... ELECTRON PARAMAGNETIC RESONANCE/NITROPRUSSIDE/ENDOTHELIAL CELLS .... ELECTROPHORESIS/HIBERNATION/OPIATE ....................................................................................... ELECTRORETINOGRAM/CHOLINESTERASES/DOG .......................................................................... ELECTROSPRAY IONIZATION/MASS SPECTROMETRY/GLUTATHIONE S-TRANSFERASE ELECTROSPRAY MASS SPECTROMETRY/QUINONE METHIDES/PROTEIN ADDUCTS ... ELISA/GUINEA PIG/ANTIBODIES................................................................................................................ ELLAGIC ACID/COCAINE/95% O2 ............................................................................................................. EMBRYO/CYP2K1/RAINBOW TROUT...................................................................................................... EMBRYOCULTURE/GLUTATHIONE/PHENYTOIN.............................................................................. EMBRYO LARVAL/FUNGAL CONTAMINATION/TOXICITY TESTING ...................................... EMBRYONIC/AH RECEPTOR/TCDD........................................................................................................... EMBRYONIC PH/DIAMIDE/FIBEROPTIC SENSORS ............................................................................ 496 EM 1142 EN< 726 ENI 596 ENI 812 ENI 813 ENI 309 ENI 987 ENI 555 ENI 389 ENI 558 ENI 1367 ENI 93 ENT 118 ENE 1174 ENE 1319 END 1324 END .706 END .709 ENE .138 ENH 1601 ENN .594 ENT 1476 ENV ..95 ENV .273 ENV .417 ENV .147 ENV. .689 ENV] .623 ENV] 1503 ENV] .679 ENV] 1180 ENV] 1637 ENV] .986 .282 ENZ3 .290 ENZ1 .286 ENZ) .725 ENZ3 .726 ENZ3 .727 ENZ3 .899 EPA ( 1481 EPICI 1478 EPIDI 1089 EPIDI .744 EPIDI .300 EPIDI .974 EPITF 1317 EPITE 1696 EPITF 1609 EPITH .592 EPOX .105 EPOX .589 EPOX 1628 ER/SP 1028 ERGC .595 ERGO 511904 0219 42 '26 >96 >12 513 509 >87 555 589 >58 567 .93 U8 174 519 524 706 709 138 501 594 176 .95 273 117 147 589 623 503 679 180 637 986 282 290 286 :* 6 7 >9 51 78 089 744 .300 .974 317 696 609 .592 .105 .589 1628 1028 .595 EMETINE/GLYCOLYSIS/CARDIAC TOXICITY ............................................................................................................................. 1435 ENCEPHALOPATHY/ANTIOXIDANT/DINITROBENZENE........................................................................................................................1343 ENDOCRINE/POLYCHLORINATED BIPHENYLS/GROWTH .....................................................................................................................222 ENDOCRINE SYSTEM/LIVER/BIOTRANSFORMATION.................................................................................................... 1330 ENDOMETRIUM/CULTURE/CARCINOGENESIS......................................................................................................................................... 1141 ENDOSULFAN/LOW NOEL/RISK ASSESSMENT........................................................................................................................................... 801 ENDOTHELIAL/CYTOCHROME/ATHEROGENESIS...................................................................................................................................1482 ENDOTHELIAL CELLS/INTERLEUKIN- 1/CELL ADHESION ASSAY..................................................................................................... 311 ENDOTHELIAL CELLS/ELECTRON PARAMAGNETIC RESONANCE/NTTROPRUSSIDE............................................................... 744 ENDOTHELIUM/DT-DIAPHORASE/QUINONEOXIDOREDUCTASE....................................................................................................1476 ENDOTOXIN/EPITHELIAL CELLS/NEUTROPHILS .......................................................................................................................................244 ENDOTOXIN/KUPFFER CELLS/TUMOR NECROSIS FACTOR...................................................................................................................247 ENDOTOXIN/CYTOKINES/AIRWAY INFLAMMATION..............................................................................................................................271 ENDOTOXIN/KUPFFER CELLS/GLUTATHIONE ........................................................................................................................................... 645 ENDOTOXIN/LIVER/PLATELETS........................................................................................................................................................................ 682 ENDOTOXIN/INTERFERON-GAMMA/TNF...................................................................................................................................................... 944 ENDOTOXIN/KUPFFES CELLS/NEUTROPHILS............................................................................................................................................1452 ENDRIN/NEUROTOXICITY/LAZAROIDU74389F (ANTIOXIDANT)................................................................................................... 1355 ENERGY CHARGE/ALLYL ALCOHOL/ATP .................................................................................................................................................. 1447 ENHANCED LEARNING/PROBLEM-BASED LEARNING/COLLABORATIVE LEARNING............................................................. 287 ENNVIRONMENTAL POLICY/PRIORmES/COMPARATTVE.................................................................................................................... 792 ENTEROHEPATIC RECIRCULATION/TOXICOKINETICS/TRICHLOROETHYLENE.......................................................................... 83 ENVIRONMENT/EDUCATION/RISK ASSESSMENT .................................................................................................................................... 290 ENVmONMENT/HYPERSENSmVTTY/PHARMACOGENETICS............................................................................................................ 1268 ENVIRONMENTAUTOXICOKINETICS/MIXTURES .......................................................................................................................................73 ENVIRONMENTAL/PUBLIC HEALTH ASSESSMENT/TRAINING.............................................................................................. 288 ENVIRONMENTAL CHEMICALS/HAZARDOUS WASTE SITES/CHEMICAL MIXTURES ............................................................. 545 ENVIRONMENTAL CONTAMINANT/MITOCHONDRIA/CYANIDE....................................................................................................... 637 ENVIRONMENTAL CONTAMINANT/LIVER ULTRASTRUCTURE/PCB CONGENER #77 ........................................................... 1459 ENVIRONMENTAL MONITORING/STRESS PROTEINS/MOLECULAR BIOMARKERS ............................................................... 1133 ENVIRONMENTAL TOBACCO SMOKE/CANCER/HEART DISEASE.....................................................................................................719 ENVIRONMENTAL TOBACCO SMOKE/ARTERIOSCLEROSIS/ACCELERATION............................................................................ 722 ENVIRONMENTAL TOXICOLOGY/BIOLOGIC MARKERS/PORPHYRINS ........................................................................................1639 ENZYME/INHTOmON/AURINTRICARBOXYLIC ACID ........................................................................................................................... 1493 ENZYME ASSAYS/PHARMACOLOGY/CHOLINERGIC..............................................................................................................................1124 ENZYME INDUCTION/CYTOCHROME P-45Q/TRANSLATION ................................................................................................................ 106 ENZYME INHTOmON/PBPK/DICHLOROMETHANE.................................................................................................................................... 376 I ENZYME-LINKED IMMUNOSORBENT ASSAY/COTININE/TOBACCO SMOKE .............................................................................1562 ! I ENZYMES/INDUCTION/LIVER ............................................................................................................................................................................ 704 l j EPA GUIDELINES/RISK ASSESSMENT/ARSENIC........................................................................................................................................... 52 ! EPICHLOROHYDRIN/HUMAN TISSUES/COVALENT BINDING............................................................................................................ 1702 | EPIDEMIOLOGY/HUMAN BIOMONITORING/IMMUNTOXICOLOGY...................................................................................................481 j EPIDERMAL GROWTH FACTOR RECEPTOR/PHOSPHOTYROSINE/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN............724 j EPIDERMIS/DERMAL/CORROSrVTTY............................................................................................................................................................... 340 EPIDIDYMIS/ESTROGEN/TESTES........................................................................................................................................................................ 209 EPITHELIAL BARRIER/PULMONARY/OXIDANT INJURY ..................................................................................................................... 1229 EPITHELIAL CELLS/NEUTROPHILS/ENDOTOXIN.......................................................................................................................................244 EPITHELIAL CELLS/FLOW CYTOMETRY/GLUTATHIONE..................................................................................................................... 1226 EPITHELIAL WJURY/REPAIR/NEUTROPHILS/CIGARETTE SMOKE ...................................................................................................275 EPOXIDE/DICHLOROETHYLENE/GLTATHIONE ....................................................................................................................................... 1052 EPOXIDE HYDROLASE/AZOLES/GENE EXPRESSION.................................................................................................................................. 89 EPOXIDE HYDROLASES/GLUTATHIONE CONJUGATION/ISOLATED PERFUSED LIVER .........................................................956 ER/SP1 INTERACTION/TRANSCRIPTION/ANTIESTROGEN ....................................................................................................................... 47 ERG C-WAVE MEASUREMENT/RETINAL PIGMENT EPITHELIUM/CYNOMOLGUS ....................................................................976 ERGOTS/PROLACTIN/FESCUE .............................................................................................................................................................................784 497 EROD/CYTOCHROME P-45Q/PCBS #77................................................................................................................................................................ 116 ERYTHEMA/SULFUR MUSTARD/SKIN............................................................................................................................................................. 666 ERYTHROCYTE/DAPSONE/HEMOLYTTC ANEMIA ..................................................................................................................................... 361 ERYTHROCYTE/ARSENIC/GLUTATHIONE................................................................................................................................................... 1015 ERYTHROCYTE/ARSENIC/GLUTATHIONE...................................................................................................................................................1016 ERYTHROCYTE/SENSmVITY/ACETYLCHOLINESTERASE................................................................................................................. 1564 ERYTHROCYTES/PEROXYL RADICAL/OXIDATIVE DAMAGE.............................................................................................................. 600 ERYTHROMYCIN/CYTOCHROME P-450/LIVER ............................................................................................................................................. 99 ERYTHROPOIETIN/ANEMIA/LEAD.................................................................................................................................................................... 897 ESR/4-NITROQUINOLINE-N-OXIDE/SUPEROXIDE.......................................................................................................................................633 ESTERASE/HYDROLASE B/CARBOXYLESTERASE................................................................................................................................... 1300 ESTERASES/METABOLISM/CADMIUM............................................................................................................................................................. 872 ESTRADIOL/CELL PROLIFERATION/HEPATOCARCINOGENESIS ....................................................................................................... 455 ESTRADIOL/TUBULEN/DIETHYLSTILBESTROL........................................................................................................................................... 458 ESTRADIOL/HEXACHLOROBENZENE/PORPHYRIA.................................................................................................................................1072 ESTRADIOL/CATECHOLESTROGENS/PARATHION................................................................................................................................... 1523 ESTRADIOL EQUIVALENTS/PCBS/ESTROGEN RECEPTOR................................................................................................................... 1066 ESTROGEN/TESTES/EPIDIDYMIS........................................................................................................................................................................ 209 ESTROGEN/TUMOR/ALBUMIN.............................................................................................................................................................................454 ESTROGEN/OXIDATIVE DAMAGE/HEPATOCYTES.....................................................................................................................................456 ESTROGEN/IGF-I RECEPTOR/CANCER.............................................. 457 ESTROGEN/ANIMAL MODEL/CARCINOGENESIS .......................................................................................................................................459 ESTROGEN/LIVER FUNCTION/TRANSAMINASE......................................................................................................................................... 693 ESTROGEN/BISPHENOL A/GENOTOXICITY ................................................................................................................................................ 1270 ESTROGEN/HEPATOCYTES/GASOLINE......................................................................................................................................................... 1441 ESTROGEN RECEPTOR/CROSS TALK/AH RECEPTOR..................................................................................................................................112 ESTROGEN RECEPTOR/ORGANOCHLORINE/REPRODUCTION ............................................................................................................ 227 ESTROGEN RECEPTOR/TCDD/OVARY............................................................................................................................................................. 730 ESTROGEN RECEPTOR/ESTRADIOL EQUIVALENTS/PCBS................................................................................................................... 1066 ESTROGEN RECEPTORS/TCDD OR DIOXIN/MOLECULAR ..................................................................................................................... 729 ESTROGENIC/THYROTOX3C/POLYCHLORINATED BIPHENYLS ........................................................................................................1058 ESTROGENS/DEHP/CLOFIBRATE.......................................................................................................................................................................1164 ETHAMBUTOL/MYCOBACTERIUMAVIUM/PHARMACOKINETICS/TOXICOKINETICS............................................................. 533 ETHANOL/XLENE/TOXICOKINETICS............................................................................................................................................................... 394 ETHANOL/P-NTTROSOPHENOL/ALCOHOL DEHYDROGENASE............................................................................................................690 ETHANOL/IMMUNOSUPPRESSION/CYTOKINES.........................................................................................................................................753 ETHANOL/TOX3CITY/CADMIUM........................................................................................................................................................................ 882 ETHANOL/CHROMIUM/CHROMATE/CR(VI)/P45Q/P450IIB/P450IIE......................................................................................................1007 ETHANOL/COCAINE/IMMUNOMODULATION............................................................................................................................................1243 ETHANOL/FLOW CYTOMETRY/NK CELL.....................................................................................................................................................1246 ETHANOL/CYP2E 1/ALCOHOL............................................................................................................................................................................. 1295 ETHANOL/CLONING/UDP-GLUCURONOSYLTRANSFERASE...............................................................................................................1322 ETHANOL/ADRENALECTOMIZED/IMMUNESYSTEM ............................................................................................................................ 1397 ETHANOL/CYTOCHROME P-45Q/PARATHION ............................................................................................................................................1524 ETHANOL-INDUCED PROMOTION/PHOSPHOUPIDS & CHOLESTEROL/D1METHYLBENZ(A)ANTHRACENE ................ 468 ETHENOGUANINE/DNA ADDUCTS/VINYL FLUORIDE............................................................................................................................ 1080 ETHYL ACRYLATE/NASAL TOXICITY/GLUTATHIONE DEPLETION ............................................................................................... 1211 ETHYL CARBAMATE/ADDUCTS/HEMOGLOBIN.........................................................................................................................................387 ETHYLENE/ETHYLENE OXIDE/PBPK MODELING.........................................................................................................................................81 ETHYLENE OXIDE/PBPK MODELING/ETHYLENE.........................................................................................................................................81 ETHYLENE OXIDE/IN VIVO/IN VITRO/TOXICOKINETICS....................................................................................................................... 384 ETHYLENE OXIDE/KINETICS/S KIN ABSORPTION.......................................................................................................................................667 ETHYLENE OXIDE/TRANSGENIC MICE/T-LYMPHOCYTE......................................................................................................................1236 ETS/CLARA CELLS/CYTOCHROME P450 ......................................................................................................................................................... 115 ETS PHASES/CYTOCHROME P-450.................................................................................................................................................................... 1678 498 511904 0221 EVOI EVOl EVOI EXCI Excr Excr Excr Excr Excr Excr Excr EXCR EXCR EXCR EXCR EXPO EXPO EXPO EXPO EXPO EXPO EXPO EXPO EXPO EXPO EXPO EXPO expr: EXTR EXTR EXTR EXTR EYE/E EYE/E EYE/fc EYEA EYE/1 EYE/1 EYE/1 EYE/1 EYE 1 EYE I FANC FATT FAIT FATT FATT FATT FC AN FELIN FEMA FEMA FEMA FENTI FERRI >16 666 361 015 016 564 600 99 897 633 300 872 455 458 072 523 066 209 454 456 457 459 693 270 441 112 227 730 066 729 058 164 533 394 690 753 '2 gVOKED POTENTIALS/TRICHLOROETHYLENE/TRIGEMINAL NERVE...........................................................................................1364 gVOKED POTENTIALS/ACUTE INHALATION/SULFURYL FLOURIDE ............................................................................................. 1373 gVOKED POTENTIALS/TEST GUIDELINES/NEUROTOXICITY ............................................................................................................ 1374 gXCIPlENTS/SAFETY GUTDELINES/PHARMACEUT1CAL INERTS ........................................................................................................796 gXCHOTOXICnY/LEAD/GLUTAMATE........................................................................................................................................................... 250 gXCITOTOXICITY/DILTIAZEM/GLUTAMATE.............................................................................................................................................. 1109 gXCITOTOXICITY/GLUTAMATE/NMDA ....................................................................................................................................................... 1346 gXCITOTOXICITY/MITOCHONDRIA/HUNTINGTON'S DISEASE ........................................................................................................ 1574 gXCITOTOXICITY/NEUROTOXINS/FREE RADICALS .............................................................................................................................. 1575 gXCITOTOXICITY/NEURODEGENERATION/C YANIDE.......................................................................................................................... 1577 EXCITOTOXINS/NEURODEGENERATIVEDISEASES/NEUROTOXICITY ........................................................................................ 1573 gXCRETTON/P-GLYCOPROTEIN/BILE..............................................................................................................................................................1439 IgXCRETION/TAMOXIFEN/P-GLYCOPROTEIN ............................................................................................................................................1596 EXCRETION/METABOLISM/PENTACHLOROANISOLE............................................................................................................................ 1714 EXCRETION/TETRACHLOROAZOBENZENE/TETRACHLOROAZOXYBENZENE.........................................................................1724 EXPOSURE/SMELTER EMISSIONS/LEAD...........................................................................................................................................................58 EXPOSURE/HAZARD/RISK....................................................................................................................................................................................1146 EXPOSURE ASSESSMENT/CONTAMINANT TRANSPORT/RISK ASSESSMENT...............................................................................546 EXPOSURE ASSESSMENT/METALS/RISK ASSESSMENT......................................................................................................................... 553 EXPOSURE ASSESSMENT/SEAFOOD CONSUMPTION/FLORIDA......................................................................................................... 563 EXPOSURE ASSESSMENT/PULMONARY TOXICITY/POLYALKYLENE GLYCOL (PAG)........................................................... 1673 EXPOSURE CONTROL/INHALATION EXPOSURES/AUTOMATED EXPOSURES.............................................................................157 EXPOSURE LIMITS/OCCUPATIONAUPHARMACEUTICALS.................................................................................................................1152 EXPOSURE MODELING/BLOOD LEAD/RISK ASSESSMENT .....................................................................................................................53 EXPOSURE SURVEY/RISK ASSESSMENT/RECREATIONAL EXPOSURES ........................................................................................550 EXPOSURE-RESPONSE/TOLUENE/TETRACHLOROETHYLENE .......................................................................................................... 1584 EXPOSURE-RESPONSE/TETRACHLOROETHYLENE/MODELING ERROR ......................................................................................1585 EXPRESSION/AH RECEPTOR/TCDD. .1032 EXTRACELLULAR ACIDOSIS/RENAL PROXIMAL TUBULE/CELL INJURY AND DEATH........................................................... 189 EXTRAPOLATION/DOSE-EFFECT/OZONE.................................................................................................................................................... 1222 EXTRAPOLATION/RISK ASSESSMENT/ACRYLAMIDE............................... 1586 EXTRATHYMIC T-CELLS/AUTOIMMUNITY/TCDD.................................................................................................................................. 1253 EYE/DRAIZE/IN VITRO............................................................................................................................................................................................309 EYE/BCOP/IRRITATION ..........................................................................................................................................................................................310 EYE/MONKEYS/BRIMONIDINE...................................................................................................................................... EYE/MONKEYS/OFLOXACIN .............................................................................................................................................................................. 977 EYE/TETRACHLORVINPHOS/OCULAR.............................................................................................................................................................978 7 EYE/IRRITATION/CORNEAL THICKNESS ......................................................................................................................................................984 3 EYE/IN VTTRO/DRAIZE.......................................................................................................................................... 6 EYE/IN VITRO ALTERNATIVES/OCULAR IRRITATION ........................................................................................................................... 988 5 EYE IRRITATION/NEW METHOD/CORNEAL THICKNESS .......................................................................................................................985 :2 EYE IRRITATION/IN VITRO/ECETOC CHEMICALS .................................................................................................................................... 986 397 FANCONI SYNDROME/MALEIC ACID/AMINO ACID TRANSPORT ......................................................................................................191 524 FATTY ACID/LIVER/CELL DEATH......................................................................................................................................................................684 468 FATTY ACID HALOETHYL ESTER SYNTHASE/CONJUGATION/2-CHOLOROETHANOL ......................................................... 1456 080 FATTY ACID HYDROXYLATION/CYTOCHROME P-450/HUMAN LIVER ........................................................................................ 1309 211 FATTY ACID OXIDATION/PEROXISOME PROUFERATORS/GEMFIBROZIL................................................................................. 1098 387 FATTY ACID-BINDING PROTEIN/PERFLUORODECANOIC ACID/ACYL-COA BINDING PROTEIN....................................... 1099 .81 FC AND FEEDER DESIGN/RAT LONGEVITY/DIETARY PROTEIN........................................................................................................1179 .81 FELINE IMMUNODEFICIENCY VIRUS (FTV)/ASTROGLIA/GLUTATHIONE ............................................................................ .. 1347 384 FEMALE/REPRODUCTTVE/TOXICOLOGY...................................................................................................................................................... 224 667 FEMALE/TOXICOKINETICS/TCDD.................................................................................................................................................................... 1042 236 FEMALE RATS/BIOCHEMICAL EFFECTS/TCDD......................................................................................................................................... 1041 115 FENTHION/RECEPTOR FUNCTION/RETINA ..................................................................................................................................................980 678 FERRETS/TOBACCO SMOKE/GLUTATHIONE S-TRANSERASES SUBUNITS..................................................................................1326 975 987 FERROCHELATASE/PORPHYRIN/DOG HEPATOCYTE ............................................................................................................................. 70j I IFERTILITY ASSAY/TOXICOLOGICAL SCREEN/CELL CYCLE.............................................................................................................. 208 FERTILIZATION/3,3',4,4'-TETRACHLOROBIPHENYL/REPRODUCTION ......................................................................................... 223 I FESCUE/ERGOTS/PROLACTIN ...................... 7g4 I FOREST FOREST FORMA FORMA] FETAL/MICROSOMAL EPOXIDE HYDROLASE/HUMAN .........................................................................................................................5g7 I FETAL/BENZO(A)PYRENE/HEMATOPOIETIC..............................................................................................................................................|559 FETAL/DIDEOXYINOSINE/DIDEOXYCYTIDINE......................................................................................................................................... 172, FETAL ALCOHOL SYNDROME/THYMUS/IMMUNOTERATOLOGY................................................................................................... 1245 ] I I FETAX/DEVELOPMENTAL TOXICITY/INTER-LABORATORY VALIDATION ................................................................... .........59o 1 pRACT/3 FREER/* FREERA FREERA FREERA FIBER/LUNG/RETENTION ......................................................................................................................................................................................l4] I FREERA FIBEROPTIC SENSORS/EMBRYONIC PH/DIAMIDE.................................................................................................................................... 59j I FREERA FIBERS/FRACTAL DIMENSION/SURFACE AREA.........................................................................................................................................140 I FREERA] IFIBERS/CARCINOGENICS/INHALATION...................................................................................................................................................... I665 IFIBERS/PARTICLES/SILICON CARBIDE WHISKERS/MESOTHELIOMA .......................................................................................... I664 FIBROSIS/DISPOSITION/INHALATION...........................................................................................................................................................1716 | FREE RAJ FREERAI FRUCTOS IFIBROUS AEROSOL/POTASSIUM OCTATTrANATE/INHALATION TOXICOLOGY....................................................................... 1672 FUMONIS FISCHER 344 RAT/PARTICLE/UPPER RESPIRATORY TRACT ................................................................................................................I43 J FUMONIS FISCHER RATS/1,3, 5-TRINITROBENZENE/SUBCHRONIC TOXICITY..................................................................................................388 | FUMONIS IFISH/IMMUNOTOXICOLOGY/METALS.........................................................................................................................................................1254a FUMONIS! FISH/ACETYLCHOLINESTERASE/PARAOXON........................................................................................................................................... 15)9 1 FUMONIS) IFISH/P-450 1A1 INDUCTION/PAHS....................................................................................................................................................................1650 FISH/PAHS/BIOMARKERS ................................................................................................................................................................................... 1657 J FLAVIN-CONTAINING MONOOXYGENASE/DIMETHYLSELENIDE/SELENIUM METABOLISM.............................................371 I FUMONIS] FUNCTION FUNCTION IFLAVONE/CYTOCHROMEP-450/INHIBITION............................................................................................................................................. 1036 FUNCTION FLAVONOEDS/THYROID HORMONES/GOLTROGEN................................................................................................................................ 1294 1 FUNCTION IFLORIDA/EXPOSURE ASSESSMENT/SEAFOOD CONSUMPTION......................................................................................................... 563 FUNCTION FLOW CYTOMETRY/TMMUNOMODULATION/HALOGENATED HYDROCARBONS ..................................................................... 19 I FUNCTION IFLOW CYTOMETRY/T-LYMPHOCYTES/LEAD............................................................................................................................................ 949 IFLOW CYTOMETRY/CELL DEATH/APOPTOSIS .........................................................................................................................................1160 FLOW CYTOMETRY/GLUTATHIONE/EPITHELIAL CELLS.....................................................................................................................1226 | FUNGAL C( FUNGICIDE G-GLUTAM FLOWCYTOMETRY/2-METHOXYETHANOL/THYMOCYTES ..............................................................................................................1252 I GABARECI FLOW CYTOMETRY/THYMOCYTE SUBPOPULATIONS/COCAINE ................................................................................................. 1254c I GABARELE FLOW CYTOMETRY/LYMPHOCTEyLOCAL LYMPH NODE ASSAY ...................................................................................................1257 I GABA-ACH FLOW CYTOMETRY/MYCOTOXIN/PROGRAMMED CELL DEATH ............................................ 1423 | GABA-ACTI IFLUORESCENCE IN SITU HYBRIDIZATION/CHROMOSOME PAJNTING/ANEUPLOIDY................................................................8 GADOLINIL FLUORESCENCE PROBES/LASER CYTOMETRY/CYTOTOXICITY.......................................................................................................778 I GADOLINIL FLUORESCENCE RATIO IMAGING/INTRACELLULAR CALCIUM/CORNEAL EPITHELIAL CELLS ......................................356 I GALACTOS, FLUORESCENCE RATIO IMAGING/INTRACELLULAR PH/CORNEAL EPITHELIUM ...................................................................357 | GALLIUM A FLUORINATED ETHERS/CYTOCHROME P-450 2E1/BIOTRANSFORMATION ...............................................................................1286 | GAPJUNCTF FLUOROALKENES/REACTIVE INTERMEDIATES/CYSTEINE S-CONJUGATES.............................................................................. 360 I GAPJUNCTIt FLUOROCARBONS/CARDIAC SENSITISATION/CHLOROFLUOROCARBONS.............................................................................................................. 1484 IGAPJUNC FLUOROMETRIC DETECTION/SUBUNIT ANALYSIS/GLUTATHION S-TRANFERASE............................................................... 1327 I GAp juncTK FLUVOXAMINE/ACETAMINOPHEN/CYTOCHROMEP-450 .................................................................................................................... 130 I GAPJUNCTK FOB/MOTOR ACTIVITY/NEUROTOXINS ......................................................................................................................................................1378 I GAPJUNCTK FOCAL GROWTH/CARCINOGENESIS/SIMULATION................................................................................................................................................................ IN4 IGAPJUN FOE 5043/LIVER/THYROXINE.............................................................................................................................................................................................................1535 IOAPJUNC FOLATE/RETTNA/METHANOL.............................................................................................................................................................................................................. 979 1GAPJUNC FOLATE/MICE/METHANOL..................................................................................................................................................................................................................1451 1GAPJUN FOLK-MEDICINES/AZARCON/LEAD................................................................................................................................................................................................. 896 1OAP-43/A FOLLICULAR DEVELOPMENT/REPRODUCTIVE SYSTEM/OOCYTE DESTRUCTION ................................................................ 2131 GAS CHROMA FOLPET TECHNICAL/INHALATION/PERCHLOROMETHYL MERCAPTAN......................................................................................l^21 Gas UPTAKE/ FOODS/CORN/FUMONISIN.....................................................................................................................................................................................776 1 QASES/VAPOf 500 511904 0223 '03 '08 '23 784 587 559 721 '45 590 141 595 140 565 564 716 572 143 388 067 54a 519 650 657 FORESTOMACH/STYRENE OXIDE/LABELING INDEX ..............................................................................................................................428 FORESTOMACH/CELL PROLIFHIATION/PROPIONIC ACID .................................................................................................................. 429 FORMALDEHYDE/AIRWAYS/AIRWAY SMOOTH MUSCLE.....................................................................................................................965 FORMALDEHYDE/DNA-PROTEINCROSSLINKS/HEXAMETHYLPHOSPHORAMIDE.................................................................. 1217 FRACTAL DIMENSION/SURFACE AREA/FIBERS......................................................................................................................................... 140 FREE RADICAL SCAVENGERS/PARAQUAT/IN VITRO TOXICOLOGY .............................................................................................1525 FREE RADICAL/OXIDANT INJURY/BCL-2/METHYL MERCURY............................................................................................................609 FREE RADICALS/CARBON TETRACHLORIDE/TYROSINE....................................................................................................................... 368 FREE RADICALS/DNA STRAND BREAKS/ASBESTOS................................................................................................................................ 855 FREE RADICALS/PENTACHLOROPHENOL/PEROXIDASE..................................................................................................................... 1077 FREE RADICALS/METHANOL/UVER TRANSPLANTATION ................................................................................................................. 1466 FREERADICALS/EXCITOTOXiaTY/NEUROTOXINS .............................................................................................................................. 1575 FREE RADICALS/ANTIOXIDANT/PHENOLS ................................................................................................................................................ 1579 FREE RADICALS/LIPID PEROXIDATION/IRON............................................................................................................................................1580 FRUCTOSE/OXIDATIVE STRESS/COCAINE.................................................................................................................................................... 615 FUMONISIN/BIOMARKERS/SPHINGOLIPID METABOLISM.................................................................................................................... 770 FUMONISIN/SPHINGOLIPID/LLC-PKi CELL ................................................................................................................................................. 772 FUMONISIN/AFLATOXIN/LrVER SLICES ........................................................................................................................................................ 773 FUMONISIN7TOXICITY/KIDNEY.......................................................................................................................................................................... 774 FUMONISIN/KIDNEY/RABBIT.............................................................................................................................................................................. 775 FUMONISIN/FOODS/CORN..................................................................................................................................................................................... 776 FUMONISIN Bl/SPHtNGOLIPID/CATFISH............................................ 771 FUNCTIONAL BEHAVIOR/PARAOXON/CHOLINESTERASE INHIBITION........................................................................................ 1371 371 FUNCTIONAL ENDPOINTS/ORGANOPHOSPHATES/MUSCARINIC RECEPTORS .......................................................................... 907 036 FUNCTIONAL OBSERVATIONAL BATTERY/NEUROTOXICITY SCREENING/CHOLINESTERASE INHIBITORS.............. 906 294 FUNCTIONAL OBSERVATIONAL BATTERY/NEUROTOXICITY/CARPETS ..................................................................................... 971 563 FUNCTIONAL OBSERVATIONAL BATTERY/NEUROPATHY/BROMOPHENYLACETYLUREA ..............................................1350 .19 FUNCTIONAL OBSERVATIONAL BA1TERY/NEUROPATHOLOGY/MOTOR ACTIVITY........................................................... 1379 949 FUNGAL CONTAMINATION/TOXICITY TESTING/EMBRYO LARVAL ............................................................................................ 1628 160 FUNGICIDE/TESTES/SPERMATOGENESIS......................................................................................................................................................267 226 G-GLUTAMYLCYSTEINE SYNTHETASE/MOLECULAR CLONING/MICE..........................................................................................641 246 GABA RECEPTOR/CATFISH/CHLORINATED AUCYCUC INSECTICIDES ....................................................................................... 917 252 GABA RECEPTOR SUBUNITS/DIELDRIN/GABA-ACTTVATED CHANNEL ....................................................................................... 918 54c GABA RELEASE/CHRONIC LEAD/GLUTAMATE RELEASE.................................................................................................................. 1128 257 GABA-A CHLORIDE CHANNELS/LINDANE/HIPPOCAMPAL NEURONS............................................................................................507 423 GABA-ACTIVATED CHANNEL/GABA RECEPTOR SUBUNTTS/DIELDRIN ....................................................................................... 918 .8 j GADOLINIUM/ULTRASTRUCTURE/MICROANALYSIS............................................................................................................................. 243 '8 ! GADOLINIUM/ACUTE TOXICITY/DIAGNOSTIC IMAGING ...................................................................................................................1023 <6 j GALACTOSAMINE/HEPATOTOXICITY/MACROPHAGES....................................................................................................................... 1449 >7 .9 36 360 484 327 .130 .378 144 1535 .979 1451 .896 .213 1662 .776 GALLIUM ARSENIDE/INDIUM ARSENIDE/RENAL ACTIVITY ............................................................................................................ 1018 GAMETOGENESIS/MEIOSIS/DIETHYLSTILBESTROL............................................................................................................................... 210 GAP JUNCTIONS/GROWTH INHIBITION/COCULTURED CELLS............................................................................................................ 131 GAP JUNCTIONS/LINDANE/CONNEXIN43...................................................................................................................................................... 132 GAP JUNCTIONS/CONNEXIN EXPRESSION/GLUCOCORTICOIDS ........................................................................................................133 GAP JUNCTIONS/CONNEXIN 43/IMMUNOCYTOCHEMISTRY.................................................................................................................134 GAP JUNCTIONS/TUMOR PROMOTERS/PHOSPHORYLATION.............................................................................................................. 135 GAP JUNCTIONS/PHTHALATES...........................................................................................................................................................................136 GAP JUNCTIONS/LEAD (PBVTCDD .................................................................................................................................................................... 137 GAP JUNCTIONS/OCTANOL/DRUG RESISTANCE ....................................................................................................................................... 138 GAP JUNCTIONS/VITAL FLUORESCENCE/MITOCHONDRIAL MEMBRANE POTENTIAL ......................................................... 139 GAP JUNCTIONS/PYRETHROID INSECTICIDES/DYE-TRANSFER ASSAY ........................................................................................689 GAP-43/ACRYLAMIDE/PERIPHERAL NEUROPATHY ................................................................................................................................ 451 GAS CHROMATOGRAPHY/ANALYSIS/UPID PEROXIDATION.............................................................................................................. 629 GAS UPTAKE/HALON REPLACEMENTS/PBPK........................................................................................................................................... 1660 GASES/VAPORS/TOXICOKINETICS/MIXTURES............................................................................................................................................. 71 501 511904 0224 GASOUNE/ESTROGEN/HEPATOCYTES GASOLINE OXYGENATE/METHYL TERT-BUTYL ETHER (MTBE)/PERCUTANEOUS ABSORPTION GASTRIC SIMULATION/LEAD BIOAVAILABILITY/IN VITRO.......................................................................... GAVAGE VOLUME/CHLOROFORM/BLOOD CONCENTRATIONS ................................................................. GC-MS ANALYSIS/TOULENE DIISOCYNATE (TDI)/BIOMARKERS ............................................................... GC/MS/BUTADIENE/METABOLITES........................................................................................................................... GCMS/MICRODIALYSIS/HYDROXYL RADICALS ................................................................................................ GEMFIBROZIL/FATTY ACID OXIDATION/PEROXISOME PROLIFERATORS............................................. GENE EXPRESSION/EPOXIDE HYDROLASE/AZOLES.......................................................................................... GENE EXPRESSION/DIFFERENTIATION/TISSUE SPECIFICITY........................................................................ GENE EXPRESSION/PEROXISOME PROLIFERATOR/PERFLUORODECANOIC ACID............................. GENE EXPRESSION/NUCLEAR RECEPTORS/SEIZURES-LINDANE ............................................................. GENE EXPRESSION/RADIATION/INTERLEUKIN-1................................................................................................. GENE EXPRESSION/HEPATOCYTES/CYTOCHROME P-450 ............................................................................... GENE EXPRESSION/HYDRAZINE/CARBON TETRACHLORIDE ...................................................................... GENE EXPRESSION/S-BR-(DIGSYL)HO/HISTONE MRNA................................................................................... GENE EXPRESSION/BENZENE/LYMPHOCYTE....................................................................................................... GENEEXPRESSION/TRICHOTHECENES/INTERLEUKINS ................................................................................. GENE EXPRESSION/INTERLEUKIN/MYCOTOXIN................................................................................................ GENE EXPRESSION/BRAIN/METALLOTHIONEIN ................................................................................................ GENE EXPRESSION/MERCURY/ALPHA-ACID GLYCOPROTEIN...................................................................... GENE EXPRESSION/TCDD/AH RECEPTOR...................................................... ...................................................... GENE EXPRESSION/LEAD/GLIAL ................................................................................................................................ GENE EXPRESSION/CYTOKINES/SUPERINDUCTION.......................................................................................... GENE EXPRESSION/SMOKE, PASSIVE/LUNG TOXICITY................................................................................... GENE INDUCTION/STRESS GENES/MOLECULAR ENDPOINT.......................................................................... GENE INDUCTION/STRESS PROTEINS/HEAT SHOCK PROTEINS................................................................... GENE MUTATION/OXYGEN RADICALS/CADMIUM ............................................................................................ GENE REGULATION/CELL PROLIFERATION/TOPOISOMERASES................................................................. GENE REGULATION/REPRESSOR/CYP1A1 .............................................................................................................. GENE REGULATION/GLUCURONIDATION/UDP-GLUCURONOSYL TRANSFERASE............................. GENERAL TOXICOLOGY/RWJ-22164/TOCOLYTIC AGENT .............................................................................. GENETIC INSTABIUTY/T47D CELLS/TCDD ............................................................................................................ GENETIC POLYMORPHISM/AGONIST AFFINITY/AH RECEPTOR ................................................................. GENETIC TOXICOLOGY/CYTOGENETICS/CHO CELLS ..................................................................................... GENISTEIN/CHEMOPREVENTION/CARCINOGENESIS....................................................................................... GENOTOXICITY/CYTOCHROME P-450/CDNA-EXPRESSION............................................................................ GENOTOXICITY/BATRACYLIN/N-ACETYLATION .............................................................................................. GENOTOXICITY/MUTATION/DNA REPAIR v.................................................................................. GENOTOXICITY/VALIDATION STUDY/MUTAGENTICITY'.............................................................................. GENOTOXICITY/METALLOTHIONEIN/CADMIUM........................................................................ .................... GENOTOXICITY/ESTROGEN/BISPHENOLA ........................................................................................................... GENOTOXICTTY/DIETHYLSTILBESTROL/MTDNA .............................................................................................. GENOTOXICITY/MICRONUCLEUS/IN VIVO ........................................................................................................... GENOTOXICITY/AMES ASSAY/MUTAGENICITY.................................................................................................. GENOTOXICITY/TRIHALOMETHANES/DNA REPAIR......................................................................................... GENOTOXICITY/MUTATION/BIOASSAY.................................................................................................................. GENOTOXICITY/ASSAY/BACTERIAL......................................................................................................................... GENOTOXICITY/TAMOXIFEN/DRUGS..................................................................................................................... GENOTOXICITY/BIOMARKERS/EARTHWORM ................................................................................................... GENOTOXICITY/SEDIMENTS/PAHS ......................................................................................................................... GENOTOXITY/QUERCETIN/MECHANISMS OF DNA DAMAGE...................................................................... GENTAMICIN/HISTOPATHOLOGY/RATS................................................................................................................ GERMANIUM TOXICITY/RENAL DYSFUNCTION/DIETARY SUPPLEMENTS ........................................ GESTATION/SALICYLATE/MATERNAL REPRODUCTIVE ............................................................................... 1441 336 559 179 1412 1413 630 109* 89 -.439 440 448 452a -.492 517 653 -.746 754 -.757 -.891 ..995 .1024 .1125 .1405 .1680 ..452 .1134 ..849 ..446 ..493 .1323 ..832 ..733 .1030 ..842 ...46 ..498 ..836 ..850 ..851 ..887 .1270 .1271 .1272 .1273 .1279 1285b 1285a .1601 .1637 .1656 .841 .. .814 .. .565 ...217 GILL. glgGLIA GLIA. glia; glon GLTA GLUC GLUC GLUC GLUC GLUC GLUC GLUC GLUO GLUO GLUC1 GLUO GLUT/ GLUT/ GLUT/ GLUT/ GLUT/ GLUT/ GLUT/ GLUT/ GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA GLUTA' GLUTA'. GLUTAT GLUTA! GLUTA! GLUTA! GLUTA! GLUTA! GLUTA! GLUTA! GLUTA! GLUTA! GLUTAT 502 511904 0225 GILLS/ALUMINUM/CALCIUM ........................................................................................................................................................................ .1655 GLG-V- 13/TOX1CITY/BRB-I-28 .............................................................................................................................................................................. 806 GLIAL/GENE EXPRESSION/LEAD .................................................................................................................................................. 1125 GLIAL CELLS/AXONAL TRANSPORT/CYTOSKELETON................................................................................................................................ 3 GLIAL FIBRILLARY ACIDIC PROTEIN/TRIMETHYLTIN/CYTOKINES.................................................................................................505 GLOMERULONEPHRTTIS/CYCLOSPORINE/INTERLEUKIN-6................................................................................................................. 1402 GLTATHIONE/EPOXIDE/DICHLOROETHYLENE ....................................................................................................................................... 1052 GLUCOCORTICOID EFFECTS/HEPATOMA CELLS/LEAD......................................................................................................................... 252 GLUCOCORTTCOIDS/GAP JUNCTIONS/CONNEXIN EXPRESSION........................................................................................................133 GLUCOCORTICOIDS/IMMUNOSUPPRESSION/APOPTOSIS................................................................................................................... 1158 GLUCONEOGENESIS/APPETITE SUPPRESSION/TCDD ............................................................................................................................1505 GLUCOSE/CYSTEINE REGULATION/RAT SMALL INTESTINE .............................................................................................................. 644 GLUCOSE TRANSPORT/TCDD/ADIPOSE TISSUE....................................................................................................................................... 1035 GLUCOSE TRANSPORT/PEROXISOME PROLEFERATORS/PERFLUOROCARBOXYLIC ACIDS .............................................. 1079 GLUCOSE-REGULATED PROTEINS/STRESS PROTEINS/HEAT SHOCK PROTEINS...................................................................... 1132 GLUCURONIDATION/UDP-GLUCURONOSYLTRANSFERASE/THYROXINE................................................................................. 1321 GLUCURONIDATION/UDP-GLUCURONOSYL TRANSFERASE/GENE REGULATION..................................................................1323 GLUCURONIDES/BILE/NICOTINE....................................................................................................................................................................1706 GLUTAMATE/EXCITOTOXICITY/LEAD...........................................................................................................................................................250 GLUTAMATE/DOMOIC ACID/AMNESIAC SHELLFISH POISONING..................................................................................................... 564 GLUTAMATE/EXCITOTOXICrrY/DILTIAZEM.................................... 1109 GLUTAMATE/AUDITORY SYSTEM/CARBON MONOXIDE ...................................................................................................................1334 GLUTAMATE/NMDA/EXCITOTOXICITY .......................................................................................................................................................1346 GLUTAMATE RELEASE/ALUMINUM/LONG-TERM POTENTIATION...................................................................................................506 GLUTAMATE RELEASE/GABA RELEASE/CHRONIC LEAD...................................................................................................................1128 | GLUTAMINE SYNTHETASE/GLUTATHIONE/PROTEIN OXIDATION...................................................................................................599 ! GLUTARALDEHYDE/ACUTE TOXICITY/IRRITANCY................................................................................................................................672 i GLUTARALDEHYDE/SENSORYIRRITATION/HYPERSENSITTVITY................................................................................................... 1208 . GLUTARALDEHYDE/GENOTOXICITY...........................................................................................................................................................1276 i GLUTATHIONS-TRANFERASE/FLUOROMETRIC DETECTION/SUBUNIT ANALYSIS............................................................... 1327 GLUTATHIONE/PHARMACOKINETICS/TOXICOKINETICS/ARSENIC...................................................................................................68 GLUTATHIONE/BENZODIAZEPINE/CYTOCHROME P-450 .........................................................................................................................94 GLUTATHIONE/p-AMINOPHENOL/NEPHROTOXICITY ............................................................................................................................181 GLUTATHIONE/DOMINANTLETHAL/ACRYLAMIDE............................................................................................................................... 202 GLUTATHIONE/SPERM/ACRYLAMIDE............................................................................................................................................................ 203 GLUTATHIONE/PHENYTOIN/EMBRYO CULTURE...................................................................................................................................... 589 GLUTATHIONE/PROTEIN OXIDATION/GLUTAMINE SYNTHETASE.................................................................................................. 599 GLUTATHIONE/OXTOATTVE STRESS/HYPOXIA...........................................................................................................................................611 GLUTATHIONE/PULMONARY ABSORPTION/NITROGEN DIOXIDE .................................................................................................. 618 GLUTATHIONE/BLOOD PLASMA, HUMAN/CYSTEINE............................................................................................................................. 639 GLUTATHIONE/CELL NUCLEUS/BIOSYNTHESIS ...................................................................................................................................... 642 GLUTATHIONE/CYSTEINE/A549 ........................................................................................................................................................................643 GLUTATHIONE/ENDOTOXIN/KUPFFER CELLS ...........................................................................................................................................645 GLUTATHIONE/OXIDATIVEINJURY/COLONOCYTES............................................................................................................................. 646 GLUTATHIONE/LASER CYTOMETRY/GLUTATHIONE S-TRANSFERASE ........................................................................................647 GLUTATHIONE/MACULAR DEGENERATION/AGING................................................................................................................................648 GLUTATHIONE/AIRWAYS/LUNG........................................................................................................................................................................ 649 GLUTATHIONE/CLARA CELLS/CYTOTOXICITY.........................................................................................................................................650 GLUTATHIONE/NEPHROTOXICITY/TERT-BUTYL-HYDROXYANISOLE .......................................................................................... 651 GLUTATHIONE/NEUROTOXICITY/tx-METHYLDOPAMINE.....................................................................................................................654 GLUTATHIONE/REPRODUCTION/4-VINYL- 1-CYCLOHEXENEDIEPOXIDE .. 1.............................................................................656 GLUTATHIONE/ALDEHYDES/STRUCTURE-ACTIVITY RELATIONSHIP............................................................................................ 658 GLUTATHIONE/ACRYLATES/IN-VITRO...........................................................................................................................................................659 GLUTATHIONE/MICROTUBULE/OOCYTE...................................................................................................................................................... 660 GLUTATHIONE/ASCORBIC ACID/AVIAN........................................................................................................................................................ 661 503 511904 0226 GLUTATHIONE/IN VTTRO/HEPATOTOXICITY ................................................................................................................................. GLUTATHIONE/QUINOLINE/8-HYDROXYQUINOLINE................................................................................................................ 7m GLUTATHIONE/CYTOKINES/NrrRIC OXIDE SYNTHASE...............................................................................................................'-'-"'ll GLUTATHIONE/UTP POOLS/MICROTUBULES ................................................................................................................................. - - - * 879 GLUTATHIONE/ANTIOXIDANT/CADMIUM..........................................................................................................................................' ` "g GLUTATHIONE/ACCUMULATION/CH3HG+-RESISTANT CELL LINE ..................................................................................... - 994 GLUTATHIONE/ACTIVE OXYGEN/SELENITE............................................ "100g GLUTATHIONE/REDOX/ARSENIC.............................................................................................................................................................. 10u GLUTATHIONE/ERYTHROCYTE/ARSENIC............................................................................................................................................ 10ls GLUTATHIONE/ERYTHROCYTE/ARSENIC............................................................................................................................................ I0,6 GLUTATHIONE/THIN-LAYER CHROMATOGRAPHY/ARSENIC ......................................................................................................... 0,7 GLUTATHIONE/MONOCHLOROACETIC ACID/ASTROCYTES ........................................................................................................ 1057 GLUTATHIONE/CHLOROFORM/COVALENTBINDING......................................................................................................................' 107g GLUTATHIONE/BLOOD-BRAIN BARRIER/METHYLMERCURY........................................................................................................ . i 8s GLUTATHIONE/CYCLOPENTADIENYL MANGANESE TRIC7LUNG ............................................................................................. [ 197 GLUTATHIONE/EPITHELIAL CELLS/FLOW CYTOMETRY................................................................................................................... . GLUTATHIONE/GLUTATHIONE S-TRANSFERASE/HUMAN TISSUES................................................................................................... GLUTATHIONE/GLUTATHIONE S-TRANSFERASE/HUMAN TISSUES..............................................................................................1325 GLUTATHIONE/FELINE IMMUNODEFICIENCY VIRUS (FIVyASTROGLIA ...................................................................................[347 GLUTATHIONE/ALPHA-NAPHTHYLISOTHIOCYANATE/LIVER......................................................................................................... 143g GLUTATHIONE/p-AMINOPHENOL/HEPATOTOXICITY......... ................................................................................................................. 1442 GLUTATHIONE/MERCURY/OXIDATTVE STRESS...................................................................................................................................... 163| GLUTATHIONE/ACETAMINOPHEN/HEPATOTOXICITY.........................................................................................................................1690 GLUTATHIONE ADDUCT/ACROLEIN/PULMONARY ENDOTHELIUM ............................................................................................. 307 GLUTATHIONE CONJUGATION/METHYLATION/CATECHOL ESTROGENS .................................................................................. 657 GLUTATHIONE CONJUGATION/ISOLATED PERFUSED LIVER/EPOXIDE HYDROLASES .................. 956 GLUTATHIONE CONJUGATION/HUMAN LIVER/CHLOROTRIFLUOROETHENE ........................................................................1053 GLUTATHIONE DEPLETION/ETHYL ACRYLATE/NASAL TOXICITY .............................................................................................. 1211 GLUTATHIONE PEROXIDASE/OXIDATIVE DAMAGE/PROMOTER REGULATORY ELEMENT.............................................. 444 GLUTATHIONE PEROXIDASE/CU/ZN SUPEROXIDE DISMUTASE/DINTTROBENZENE.............................................................1344 GLUTATHIONE PEROXIDASE/COPPER-DEFICIENCY/CATALASE.....................................................................................................I486 GLUTATHIONE S-TRANSERASES SUBUNITS/FERRETS/TOBACCO SMOKE.................................................................................1326 GLUTATHIONE S-TRANSFERASE/GLUTATHIONE/LASER CYTOMETRY .......................................................................................647 GLUTATHIONE S-TRANSFERASE/RABBIT/PRIMARY CULTURED HEPATOCYTES ................................................................. 1314 GLUTATHIONE S-TRANSFERASE/ELECTROSPRAY IONIZATION/MASS SPECTROMETRY ..................................................1317 GLUTATHIONE S-TRANSFERASE/HUMAN TISSUES/GLUTATHIONE.............................................................................................. 1318 GLUTATHIONE S-TRANSFERASE/HUMAN TISSUES/GLUTATHIONE.............................................................................................. 1325 GLUTATHIONE S-TRANSFERASE/PENTACHLOROPHENOL/MTTOCHONDR1AL TOXICITY ................................................. 1455 GLUTATHIONE S-TRANSFERASE YC2/INDOLE-3-CARBINOL/AFLATOXIN B1 ............................................................................. 43 GLUTATHIONETRANSFERASE/BENZENE/HPRT MUTATION ........................................................................................................... 1278 GLUTATHIONE TRANSFERASES/TESTICULAR METABOLISM/CYTOCHROME P-450 1A ....................................................... 262 GLYCINE/CAROLINA RINSE/TRANSPLANTATION................................................................................................................................... 620 GLYCINE RECEPTOR/CELL DEATH/RENAL PROXIMAL TUBULE.......................................................................................................190 GLYCOL/TRIETHYLENE GLYCOL/TERATOLOGY..................................................................................................................................... 571 GLYCOLYSIS/CARDIAC TOXICITY/EMETINE ...........................................................................................................................................1485 GLYCOSAMINOGLYCAN/KIDNEY/ALPHA2U-GLOBULIN...................................................................................................................... 816 GLYCOSAMINOGLYCAN/SULFATTON/MOLYBDENUM.........................................................................................................................1329 GOLTROGEN/FLAVONOIDS/THYROID HORMONES................................................................................................................................1294 GPIIB/1IIA/DMP 728/BLEEDING TIME............................................................................................................................................. 817 GP120/ADJUVANTS/ALUMINUM....................................................................................................................................................................... 534 GRANULOSA/PROGESTERONE/HEAVY METALS ......................................................................................................................................327 GREAT LAKES FISH/PCBS/MINK......................................................................................................................................................................1643 GREAT LAKES FISH/PCBS/MINK..................................................................................................................................................................... 1644 GROWTH/ENDOCRINE/POLYCHLORINATED BIPHENYLS ....................................................................................................................222 GROWTH CONE/MORPHOLOGY/ACRYLAMIDE ........................................................................................................................................ 769 GRO gro GRO GSH/ GUD GUIF GUN H-R4 HA-F HAE1 HAH HALF HALF HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAL* HAM HAZj HAZi HAZj HAZu HAZu HAZj HAZj HAZj HAZ. HAZ. HCB/ HCF( HCFC HCG/ HEAI HEAI HEAI HEAI HEAI HEA'. HEA" HEA' HEA" HEA' HEA' HEA' 511904 0227 GROWTH FACTORS/IN VITROTESTING/ACRYLAMIDE ........................................................................................................................1360 GROWTH HORMONE/CYTGCHROME P-450/RAINBOW TROUT.............................................................................................................128 GROWTH INHIBITION/COCULTURED CELLS/GAP JUNCTIONS.............................................................................................................131 GSH/ANABOLIC-ANDROGENIC STEROIDS/LIVER CELL CULTURE...................................................................................................692 GUINEA PIG/HEPATOTOXICITY/HCFC-123 .................................................................................................................................................. 1069 GUINEA PIG/ANTIBODIES/ELISA.......................................................................................................................................................................1609 GUNN RAT/BENZENE/HEMATOTOXICITY .................................................................................................................................................. 1554 H-RAS GENE/PANCREAS/MUTATIONS.............................................................................................................................................................513 HA-RAS/MOUSE LIVER/DNA METHYLATION ................................................................................................................................. 514 HAEMODYNAMIC/PDE III INHIBITOR/ARTERIOPATHY ........................................................................................................................1483 HAHS/RISK ASSESSMENT/TCDD............................................................................................................... 411 HA1R/2.5-HEXANEDIONE/PYRROLE................................................................................................................................................................ 1414 HAIR CELL/REACTIVE OXYGEN SPECIES/COCHLEA................................................................................................................................ 329 HALOACETATES/LIVER/8-HYDROXYDEOXYGUANOSINE ................................................................................................................. 1465 HALOANILINES/NEPHROTOXICITY/HEPATOTOXICrrY.......................................................................................................................... 172 HALOCARBON/METABOLISM/IN VITRO.......................................................................................................................................................1068 HALOGENATED HYDROCARBONS/FLOW CYTOMETRY/IMMUNOMODULATION ...................................................................... 19 HALOGENATED HYDROCARBONS/HEPATOTOXJCITY/IN VITRO ....................................................................................................... 32 HALOGENATED HYDROCARBONS/TOXICOKINETICS/MIXTURES ..................................................................................................... 70 HALOGENATED HYDROCARBONS/DNA ADDUCTS/1,2.3-TRICHLOROPROPANE.................................................................... 1283 HALOGENATED HYDROCARBONS/ANESTHETICS/HEPATOTOXICITY.......................................................................................... 1462 HALOGENATED HYDROCARBONS/POLYCYCLIC AROMATIC HYDROCARBONS/COMPLEX MIXTURES..................... 1563 HALOGENATED PESTICIDE/TUMOR PROMOTERS/MULTISTAGE CARCINOGENESIS .............................................................463 HALON REPLACEMENTS/PBPK/GAS UPTAKE......................................................................................................................................... 1660a HALOTHANE/PHARMACOKINETICS/HCFC-123............................................................................................................................................. 66 HALOTHANE/PROTEIN ADDUCTS (TFA ADDUCTSyE-LYSINE ACYLASE ..................................................................................... 679 HALOTHANE/CROSSREACTIVITY/ANTIBODY ......................................................................................................................................... 1608 HALOTHANE/HEPATOTOXICITY/ADDUCT TURNOVER ....................................................................................................................... 1683 HAMSTER/DIETARY LIPIDS/HEPATOTOXICITY ........................................................................................................................................ 694 HAZARD/CHAPARRAL/HEPATOTOXICITY................................................................................................................................................... 566 HAZARD/RISK/EXPOSURE................................................................................................................................................................................... 1146 HAZARD ASSESSMENT/IMMUNOTOXICOLOGY/MEDAKA .............................................................................................................. 1254b HAZARD EVALUATION/MECHANISMS/TOXICITY ASSESSMENTS .................................................................................................1633 HAZARD IDENTIFICATION/SHEEP RED BLOOD CELLS/HUMORAL IMMUNITY.......................................................................... 400 HAZARD IDENTIFICATION/IMMUNOTOXICITY/R1SK ASSESSMENT................................................................................................ 477 HAZARD RANKING/OSHA/REPRODUCTTVE EFFECTS............................................................................................................................. 793 HAZARD SCREENING/OCCUPATIONAL EXPOSURE/RISK ASSESSMENT......................................................................................1150 HAZARDOUS WASTE SITES/CHEMICAL MIXTURES/ENVIRONMENTAL CHEMICALS .............................................................545 HAZARDOUS WASTE SITES/CHEMICALS OF CONCERN/COMPUTER PROGRAM...................................................................... 1147 HCB/DERMAL ABSORPTION/VOLATILE ...................................................................................................................................................... 1528 HCFC-123/HALOTHANE/PHARMACOKINETICS............................................................................................................................................. 66 HCFC-123/GUINEA PIG/HEPATOTOXICITY .................................................................................................................................................. 1069 >0 HCG/BENZO(A)PYRENE/EGF RECEPTOR........................................................................................................................................................ 727 'I HEART/ANTIMONY/OXIDATIVE STRESS ...................................................................................................................................................... 608 >5 HEART/PHENOXYL RADICAL/VITAMIN E ....................................................................................................................................................612 ,6 HEART CELL CULTURES/METABOLISM/COCAINE ................................................................................................................................ 1473 !9 HEART CELL CULTURES/ANABOLIC-ANDROGENIC STEROIDS/INTRACELLULAR CALCIUM............................................1474 )4 HEART DISEASE/ENVIRONMENTAL TOBACCO SMOKE/CANCER..................................................................................................... 719 17 HEAT SHOCK/TESTES/HEME OXYGENASE.................................................................................................................................................... 261 !4 HEAT SHOCK/CHEMICAL STRESS/RENAL TRANSSPORT..................................................................................................................... 1135 >7 HEAT SHOCK PROTEINS/HEPATOTOXICITY/STRESS PROTEINS ....................................................................................................... 452 13 HEAT SHOCK PROTEINS/GLUCOSE-REGULATED PROTEINS/STRESS PROTEINS.......................................................................1132 14 HEAT SHOCK PROTEINS/GENE INDUCTION/STRESS PROTEINS........................................................................................................1134 22 HEAVY METALS/GRANULOSA/PROGESTERONE .......................................................................................................................................327 >9 HEAVY METALS/METAL INTERACTIONS/RAT LYMPHOCYTE RESPONSE ................................................................................... 419 505 511904 0228 heavy METALS/8-OXOGUANINE/CHELATORS.............................................................................................................. HEINZ BODY/ACETAMINOPHEN/CATS ................................................................................................................................ HEINZ BODY/ANEMIA/METHEMOGLOB IN......................................................................................................................... HEMATOLOGIC TOXICITY/PHOTOVOLTAIC METALS/DEVELOPMENTAL TOXICITY .................................. HEMATOPOIETIC/FETAL/BENZO(A)PYRENE.................................................................................................................... HEMATOPOIETIC/BONE MARROW/ANTIPSYCHOTTC/OLANZAPINE/PROGENITOR CELLS/STEM CELLS HEMATOTOXICITY/GUNN RAT/BENZENE ......................................................................................................................... HEME OXYGENASE/HEAT SHOCK/TESTES......................................................................................................................... HEME PATHWAY PARAMETERS/BIOMARKERS/LEAD ................................................................................................ HEMGLOBIN/DINITROBENZENE/ADDUCTS....................................................................................................................... HEMOGLOBIN/ETHYL CARBAMATE/ADDUCTS .............................................................................................................. HEMOGLOBIN/SULFHYDRYL GROUPS/BIOMONTTORING.......................................................................................... HEMOGLOBIN/4-AMINOBIPHENYL/SMOKERS ................................................................................................................ HEMOGLOBIN ADDUCTS/PYRROLES/BIOMARKERS..................................................................................................... HEMOLYSIS/IN VITRO/ARSINE ............................................................................................................................................... HEMOLYSIS/HEPATOTOXICITY/ANTILEIS HMANIAL................................................................................................... HEMOLYTIC ANEMWERYTHROCYTE/DAPSONE ........................................................................................................... HEMOPOIESIS/PROPANIL/STEMCELL .................................................................................................................................... HEMORRHAGIC CYSTITIS/ACROLEIN MERCAPTUR1C ACIDS/CYCLOPHOSPHAMIDE.................................... HEN/ORGANOPHOSPHATE-INDUCED DELAYED NEUR/PHENYL SALIGENIN PHOSPHATE ........................ HEPATIC/CHOLESTASIS/2,6-DI-T-BUTYL-4-NTTROPHENOL......................................................................................... HEPATIC ALIESTERASES/ACETYLCHOLINESTERASEINHIBITION/ORGANOPHOSPHATES........................ HEPATIC CYTOCHROME P450/KETAMINEL ANESTHESIA/CADMIUM/VERAPAMIL........................................ HEPATIC CYTOLETHALITY/PKC INHIBITOR/SEX DIFFERENCES............................................................................ HEPATIC SUCE/TRANSPORT/M-741 ...................................................................................................................................... HEPATIC TUMOR PROMOTION/TRANSGENIC MICE/TGF-ALPHA............................................................................ HEPATOPROTECnON/CHOLESTEROL SUCCINATE/CARBON TETRACHLORIDE........................................... HEPATOBILIARY FUNCTION/BILIARY EPITHELIUM/CELL PROLIFERATION..................................................... HEPATOBILIARY TOXICITY/BILIARY HYPERPLASIA/BILIARY TREE..................................................................... HEPATOCARCINOGENESIS/ESTRADIOL/CELL PROLIFERATION.............................................................................. HEPATOCARCINOGENESIS/BIOTRANSFORMATION/ACETYLAMINOFLUORENE............................................. HEPATOCARCINOGENESIS/PROGRESSION/ALTERED ENZYME PHENOTYPE ................................................. HEPATOCARCINOGENICITY/DNA ADDUCT FORMATION/TRIPHENYLETHYLENE DRUGS ......................... HEPATOCARCINOMA/TAMOXIFEN/P53 ANTIONCOGENE ........................................................................................... HEPATOCELLULAR REGENERATION/LIVER INJURY/ISOPROPANOL..................................................................... HEPATOCYTE HYPERTROPHY/INHALATION TOXICITY/PCBTF................................................................................ HEPATOCYTES/SECOND MESSENGERS/CYTOCHROME P-450 .................................................................................. HEPATOCYTES/INDUCTION/CYTOCHROME P-450 ........................................................................................................... HEPATOCYTES/NTIRIC OXIDE/NEUTROPHILS .................................................................................................................. HEPATOCYTES/DICHLOROMETHANE/DNA-PROTEINCROSS-LINKS ................................................................... HEPATOCYTES/AZOLEANTIFUNGALS/CYTOTOXICITY ............................................................................................. HEPATOCYTES/ESTROGEN/OXIDATIVE DAMAGE......................................................................................................... HEPATOCYTES/CYTOCHROME P-450/GENE EXPRESSION.......................................................................................... HEPATOCYTES/ACUTE PHASE PROTEINS/LPS (ENDOTOXIN)................................................................................... HEPATOCYTES/DOSE-DEPENDENTHEPATOTOXICITY/CAFFEINE ........................................................................ HEPATOCYTES/CELL PROLIFERATION/TCDD.................................................................................................................. HEPATOCYTES/POLYCYCLIC AROMATIC HYDROCARBONS/DNA SYNTHESIS............................................... HEPATOCYTES/ALLYL ALCOHOL/CRYOPRESERVATlON .......................................................................................... HEPATOCYTES/CHARACTERIZATION/BILIARYEPITHELIUM ................................................................................. HEPATOCYTES/CHARACTERIZATION/BILIARYEPITHELIUM ................................................................................. HEPATOCYTES/CULTURE/HEPATOTOXICITY.................................................................................................................. HEPATOCYTES/CELL KILLING/ALUMINUM....................................................................................................................... HEPATOCYTES/DNA REPAIR INHIBITORS/ACETAMINOPHEN ................................................................................. HEPATOCYTES/GASOLINE/ESTROGEN................................................................................................................................ HEPATOCYTES/PERICENTRAL TOXICITY/TNF-a ............................................................................................................ 506 999 - 809 1548 1019 1559 1549 1554 261 .253 .321 387 655 --1472 - - -1415 .320 - 1552 .361 ...1558 .369 -.1532 . .681 ...1533 ... .878 ... .322 .........34 ... .962 ... .678 ... .431 ....712 ... .455 ... .848 ....964 ...1599 ...1600 ...1448 ...1213 ....113 ....123 ... .246 ....324 ... .325 ... .456 ... .492 ... .683 ....697 ... .959 ...1029 ...1088 ...1091 ...1093 ...1095 ...1182 .. .1285 .. .1441 ...1444 HEP4 HEPA HEP4 HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA HEPA' HEPA HEPA' HEPA' HEPA" HEPA' HEPA' HEPA". HEPA! HEPA7 HEPA1 HEPA1 HEPA1 HEPA" HEPA HEPA HEPA HEPA' HEPA'. HEPA1 HEPA! HEPG2 HEPM< HEPTA HEPTA HEPTA HERB! HETER HETER HEXA( HEXAC 511904 0229 >99 (09 (48 >19 (59 (49 (54 '61 253 521 587 (55 172 115 320 552 361 558 369 532 581 533 878 322 .34 962 678 431 712 455 848 964 599 600 448 713 3 :3 6 '.4 15 56 492 683 697 959 029 088 091 093 095 182 285 1441 1444 HEPATOCYTES/ALLYLALCOHOL/CAFFEINE ............................................. HEPATOCYTES, RAT, HUMAN/1,6-DINITROPYRENE/HUMAN LIVER HEPATOTOXICITY/INVITRO/HALOGENATED HYDROCARBONS .. hepatotoxicity/bioacttvation/nephrotoxictty.................... HEPATOTOXICITY/HALOANILINES/NEPHROTOXICITY...................... HEPATOTOXICITY/REACnVE INTEMEDIATE/COVALENT BINDING HEPATOTOXICITY/LIVER SLICES/CRESOL................................................. HEPATOTOXICITY/STRESS PROTEINS/HEAT SHOCK PROTEINS ........................ HEPATOTOXICITY/HAZARD/CHAPARRAL..................................................................... HEPATOTOXICITY/PYRRROLIZIDINE ALKALOIDS/CARCINOGENICITY......... HEPATOTOXICTTY/HAMSTER/DIETARY LIPIDS .......................................................... HEPATOTOXICTTY/GLUTATHIONE/IN VITRO .............................................................. HEPATOTOXICITY/COCAINE/COCAETHYLENE .......................................................... HEPATOTOXICmVADRENERGIC ANTAGONISTS/BROMOBENZENE................ HEPATOTOXICTTY/DICHLOROBENZENE/INTERACnVE.......................................... HEPATOTOXICITY/REACnVE-METABOLITE/ACYLGLUCURONIDE ............... HEPATOTOXICTTY/PARACETAMOL/CYTOKINES.................... .................. ............. HEPATOTOX3CITY/CYTOKINES/MACROPHAGES....................................................... HEPATOTOXICITY/CYANOBACTERIALALKALOID/CYLINDROSPERMOPSIN HEPATOTOX3CITY/CADMIUM/METALLOTHIONEIN................................................. HEPATOTOXICITY/CARBON TETRACHLORIDE/POTENTIATION ........................ HEPATOTOXICITY/HCFC-123/GUINEA PIG..................................................................... HEPATOTOXICITY/HEPATOCYTES/CULTURE.............................................................. HEPATOTOXICITY/ANTICANCER AGENTS/MYELOTOXICITY ............................. HEPATOTOXICTTY/ANTIGENIC BIOMARKER/ACETAMINOPHEN ...................... HEPATOTOXICTTY/GLUTATHIONE/p-AMINOPHENOL............................................... HEPATOTOXICITY/TAURINE/METHYLENE DIANILINE .......................................... HEPATOTOXICITY/MACROPHAGES/GALACTOSAMINE.......................................... HEPATOTOXICITY/RAT STRAIN COMPARISON/CARBON TETRACHLORIDE . HEPATOTOX3CITY/HALOGENATED HYDROCARBONS/ANESTHETICS............. HEPATOTOXICITY/CARBON TETRACHLORIDE/CELL REPLICATION............... HEPATOTOXICITY/ANTILEISHMANIAL/HEMOLYSIS .............................................. HEPATOTOXICITY/ADDUCTTURNOVER/HALOTHANE.......................................... HEPATOTOXICITY/COVALENT BINDING/DICLOFENAC.......................................... HEPATOTOXICITY/ACETAMINOPHEN/COVALENT BINDING............................... HEPATOTOXICITY/ACETAMINOPHEN/COVALENT BINDING............................... HEPATOTOX3CITY/GLUTATHIONE/ACETAMINOPHEN............................................ HEPATOTOXICITY/ACETAMINOPHEN/COVALENT BINDING ............................... HEPATOTOXICTTY/ACETAMINOPHEN/COVALENTBINDING............................. HEPATOTOXICTY/ACETAMINOPHEN/COVALENT BINDING............................... HEPG2 CELLS/BERBERINE/CELL CYCLE......................................................................... HEPM CELLS/DEVELOPMENTAL TOXICITY/CHLOROPHENOLS......................... HEPTA-CDD/TCDD/SUBCHRONIC TOXICITY.............................................................. HEPTA-CDD/TCDD/SUBCHRON1C TOXICITY.............................................................. HEPTA-CDD/TCDD/SUBCHRONIC TOXICITY/PATHOLOGY................................. HERBICIDES/NITROGEN-FIXATION/NTTRIFICATION............................................... HETEROCYCLIC AMINE/CHEMOPREVENTION/ANTIOXIDANT ......................... HETEROCYCLIC AMINE/CHEMOPREVENTION/ANTIOXIDANT ......................... HEXACHLOROBENZENE/ULTRASTRUCTURE/MONKEY OVARY...................... HEXACHLOROBENZENE/ALCOHOL/PORPHYRIA..................................................... 507 .1454 ..323 ..252 . .815 ...31 ...32 .170 .172 . .358 . .362 .363 . .421 ..452 .566 .567 .694 .695 .696 .699 .701 .715 .747 .748 . .786 .888 1051 1069 1095 1105 1408 1442 1443 1449 1460 1462 1463 1552 1683 1684 1687 1688 1690 .1692 1693 1686 . .783 . .328 .1038 .1039 .1040 .1435 . .638 ..958 ..211 .1071 511904 0230 HEXACHLOROB ENZENE/PORPHYRIA/ESTRADIOL................................................................................... HEXACHLOROBENZEN^/PHOSPHOLIPIDS/PORPHYRIA............................................................................ HEXACHLOROB ENZENE/PORPHYR1A/BINDING........................................................................................... HEXACHLOROBIPHENYL/PREGNANCY/CYTOCHROME P-450 .............................................................. HEXAMETHYLENE DIISOCYANATE/ADAPTION/INHALATION.............................................................. HEXAMETHYLPHOSPHORAM1DE/FORMALDEHYDE/DNA-PROTEINCROSSLINKS ...................... HEXAMETHYPHOSPHORAMIDE/CELL PROLIFERATION/NASAL TOXICITY.................................... HEXAVALENT CHROMIUM/MUTAGENICITY/MUTAMOUSE................................................................... HIBERNATION/OPIATE/ELECTROPHORESIS .................................................................................................. HIGH PRESSURE LIQUID CHROMATOGRAPHY/COCAINE/THIN LAYER CHROMATOGRAPHY HIGH SCHOOL/EDUCATION/RECRUITMENT .................................................................................................. HIPPOCAMPAL NEURONS/PROTEIN KINASES/LEAD.................................................................................. HIPPOCAMPAL NEURONS/GABA-A CHLORIDE CHANNELS/LINDANE............................................... HIPPOCAMPAL NEURONS/NICOTINE/AXON BRANCHING....................................................................... HIPPOCAMPAL SLICE/METHYLMERCURY/NEURONAL EXCITABILITY............................................. HIPPOCAMPUS/LEAD/MUSCARINIC RECEPTOR........................................................................................... HIPPOCAMPUS/LEAD/PROTEIN KINASE C ...................................................................................................... HISTIOCYTOSIS/WHITE OIL/MICROGRANULOMATA ................................................................................ HISTOMORPHOMETRY/MARMOSETS/OSTEOPOROSIS.............................................................................. HISTOMORPHOMETRY/CADMIUM/BONE REMODELING.......................................................................... HISTONE MRNA/GENE EXPRESSION/S-BR-(DIGSYL)HO............................................................................ HISTOPATHOLOGY/TESTES/SEMEN.................................................................................................................... HISTOPATHOLOGY/SEMEN/TESTES.................................................................................................................... HISTOPATHOLOGY/INHALATION/SMOKE...................................................................................................... HISTOPATHOLOGY/RATS/GENTAMICIN........................................................................................................... HISTOPATHOLOGY/LIFE-CYCLE-STAGES/MEDAKA.................................................................................. HISTORICAL CONTROL DATA/NEUROTOXICITY SCREENING BATTERY/RODENTS .................. HORMESIS/REGENERATION/METALS............................................................................................................... HORMONALLY-MEDIATED/CARCINOGENESIS/THYROID....................................................................... HORMONE/BEHAVIOR/NURSING DISORDER.................................................................................................. HORMONES/CYTOCHROME P-450/RAINBOW TROUT ................................................................................ HOST RESISTANCE/IMMUNOMODULATION/PREDNISOLONE .............................................................. HOST RESISTANCE/BACTERIAL CHALLENGE/INTERLEUKIN-1 RECEPTOR ANTAGONIST HOST RESISTANCE/IMMUNOSUPPRESSION/T-2 TOXIN ............................................................................ HOST-RESISTANCE/PYRIMETHAMINE/IMMUNE FUNCTION................................................................... HOUSEHOLD CLEANERS/COLORIMETRIC GRADING/CLINICAL SKIN MILDNESS ...................... HPLC/ANTIOXIDANT/MASS SPECTROMETRY................................................................................................ HSCAS OR CLAY/AFLATOXIN/METABOLISM ............................................................................................... HSP27/STRESS PROTEIN/CADMTUM/TESTIS/SERTOLI CELL..................................................................... HUMAN/MICROSOMES/CYTOCHROME P-450.................................................................................................. HUMAN/DIAZEPAM/CYTOCHROME P-450 .................................................................................................... HUMAN/STABILITY/CYTOCHROME P-450 .................................................................................................... HUMAN/FETAL/MICROSOMAL EPOXIDE HYDROLASE .......................................................................... HUMAN/TOXICOLOGY/CARCINOGENESIS.................................................................................................... HUMAN/TISSUE/RESOURCE.................................................................................................................................. HUMAN/CARCINOGENICITY/METABOLISM ................................................................................................ HUMAN/METHAMIDOPHOS/OPIDP.................................................................................................................... HUMAN/TAMOXIFEN/CYTOCHROME P-450 .................................................................................................. HUMAN/LANGERHANS CELLS/ANTIGEN PRESENTATION ................................................................... HUMAN BIOMONITORING/IMMUNTOXICOLOGY/EPIDEMIOLOGY................................................... HUMAN BIOMONITORING/32P-POSTLABELING/DNA ADDUCTS ........................................................ HUMAN BLOOD/DISTRIBUTION/TCDD ........................................................................................................... HUMAN EXPOSURE/HYDROQUINONE/NATURAL PRODUCTS ............................................................ HUMAN FETAL TISSUE/BIOTRANSFORMATION/COCAINE ................................................................... HUMAN ISOZYMES/P-NITROSOPHENOL/ALCOHOL DEHYDROGENASE ........................................ 508 511904 0231 1072 1073 1698 1061 1589 1217 1218 943 TOO 1565 282 501 507 .509 .500 .502 .503 .688 .831 1190 .653 206 .266 .721 .814 1632 1375 1436 .461 .219 .127 .408 1403 1404 .409 1269 1566 .777 .269 ..98 .107 .110 ..587 1137 1138 .1139 .1534 .1597 .1604 ..481 .1417 .1044 ..788 .1087 .1306 HUM. HUM, HUM, HUM, HUM, HUM, HUM HUM, HUM HUM HUM HUM HUM HUM HUM HUM HUM HUM, HUM/ HUM HUM HUM, HUM, HUM, HUM< HUM< HUNT HYDF HYDF HYDF HYDF HYDF HYDF HYDF HYDE HYDF HYDF HYDI HYDI HYD! HYDI HYD! HYDI HYDI HYDF HYDF HYDF HYDF HYDF HYPE HYPE HYPE HYPE HYPE HYPE HUMAN LIVER/WARFARIN METOBLISM/CRYPRESERVATION, SLICES...................... 2 HUMAN LIVER/HEPATOCYTES, RAT, HUMAN/1,6-DINITROPYRENE ........................... 3 ! HUMAN LIVER/CHLOROTRIFLUOROETHENE/GLUTATHIONE CONJUGATION ......... 8 : HUMAN LIVER/FATTY ACID HYDROXYLATION/CYTOCHROME P-450 ...................... 1 HUMAN LIVER/TAMOXIFEN/32P-POSTLABELLING................................................................ 9 HUMAN LIVER SLICES/CYROPRESERVATION, SLICES/CYRO INDUCED TOXICITY 7 HUMAN LUNG/AFLATOXINBi/BIOACTIVATION..................................................................... 8 HUMAN LYMPHOBLASTOID CELLS/TRANSCRIPTION FACTOR KB/CELL DENSITY 3 HUMAN LYMPHOCYTES/SISTER CHROMATID EXCHANGES/STYRENE OXIDE......... 0 HUMAN MAXIMIZATION TEST/LOCAL LYMPH NODE ASSAY/CONTACT ALLERGY 5 HUMAN PLACENTA/CADMIUM/CELL PROLIFERATION...................................................... 2 HUMAN PLACENTA/METALLOTHIONEIN/CADMIUM.......................................................... 1 HUMAN PLACENTA/AFLATOXIN Bi/LIPOXYGENASE............................................................ 7 HUMAN SKIN/CORROSION/IN VITRO............................................................................................. 9 HUMAN SKIN/IRRITATION/IN VITRO............................................................................................. 0 HUMAN SKIN/PHOTOTOXICITY/IN VITRO.................................................................................. 2 HUMAN TISSUES/PAPILLOMAVIRUS/CYTOCHROME P-450 ................................................. 3 HUMAN TISSUES/GLUTATHIONE/GLUTATHIONE S-TRANSFERASE............................... 8 j HUMAN TISSUES/GLUTATHIONE/GLUTATHIONE S-TRANSFERASE............................... I HUMAN TISSUES/CARCINOGENESIS/PESTICIDES ................................................................... 0 ! HUMAN TISSUES/COVALENT BINDING/EPICHLOROHYDRIN............................................ 3 j HUMAN TISSUES/SUBJECTS/CYTOCHROME P-450/BIOTRANSFORMATION............... 6 ! HUMAN VOLUNTEERS/DEET/DERMAL ABSORPTION............................................................ 6 | HUMANS/SKIN/CONTACT SENSITIZATION ................................................................................ 1 4 j HUMORAL IMMUNITY/CARBARYL/INHALATION ................................................................... 2 | HUMORAL IMMUNITY/HAZARD IDENTIFICATION/SHEEP RED BLOOD CELLS......... 5 1 HUNTINGTON'SDISEASE/EXCITOTOXICITY/MITOCHONDRIA ........................................ ! HYDRALAZINE/N-ACETYLTRANSFERASE/MUTAGENICITY............................................... 6 1 HYDRAZINE/CARBON TETRACHLORIDE/GENE EXPRESSION .......................................... 9 HYDRAZINES/DRUG METABOLISM/CYTOCHROME P-450 ................................................... 7 HYDROCARBON/IN VITRO/MARINE MAMMAL...........................................*............................. 8 HYDROCARBON/IN VITRO/MARINE MAMMAL......................................................................... 3 HYDROCARBON NEPHROPATHY/MALE RAT NEPHROPATHY/NEPHROPATHY......... 4 HYDROCEPHALUS/BEHAVIOR/ZALCITABINE............................................................................ 9 HYDROCHLOROFLUOROCARBONS/BIOTRANSFORMATION/METABOLITES............. HYDROGEN CHLORIDE/CHLOROSILANES/VAPOR INHALATION .................................... HYDROGEN CHLORIDE/CHLOROSILANES/VAPOR INHALATION .................................... HYDROGEN SULFIDE/AIR STANDARDS/TOXICOKINETICS................................................. HYDROLASE B/CARBOXYLESTERASE/ESTERASE................................................................... HYDROQUINONE/KIDNEY/COVALENT ADDUCTS................................................................... HYDROQUINONE/PHENOLS/KINETICS ......................................................................................... HYDROQUINONE/KIDNEY/CELLPROLIFERATION ................................................................ 7 HYDROQUINONE/COPPER/REACTTVE OXYGEN....................................................................... 7 HYDROQUINONE/SUPEROXIDE DISMUTASE/REACTTVE OXYGEN................................. 8 HYDROQUINONE/NATURAL PRODUCTS/HUMAN EXPOSURE .......................................... 9 HYDROXYL FREE RADICALS/MITOCHONDRIA/OXIDATIVE DAMAGE ........................ 4 HYDROXYL RADICAL/DENTIFRICE/INHIBITION ..................................................................... 7 HYDROXYL RADICAL/OXIDATTVE DAMAGE/DNA NICKING ............................................ 4 HYDROXYL RADICALS/GCMS/MICRODIALYSIS ..................................................................... 1 ; HYPEROXIA/OXYGEN RADICALS/AGE......................................................................................... 7 : HYPERPLASIA/BILIARY OBSTRUCTION/BILIARY EPITHELIUM........................................ 4 ; HYPERSENSITTVITY/SILICONES/ADJUVANCY ......................................................................... 5 : HYPERSENSITIVITY/GLUTARALDEHYDE/SENSORY IRRITATION................................... 7 ! HYPERSENSITTVITY/PHARMACOGENETICS/ENVIRONMENT............................................ 6 Ii HYPERSENSITTVITY/IGE/RESPIRATORY...................................................................................... 509 .. .37 .323 .1053 .1309 .1602 .1567 .1305 . .449 . .843 .1255 .425 . .884 .1292 .345 .346 .347 .490 1318 1325 1541 1702 1307 .665 .557 ..15 .400 1574 .845 .517 .118 1645 1646 .169 .528 1070 1198 1199 .794 1300 .201 .391 .437 .597 .598 .788 603 . .602 . .604 . .630 . .601 . .716 . .20 .1208 .1268 .1610 511904 0232 HYPERSENSITIVITY/INFLUENZA VIRUS/OVALBUMIN........................... HYPERTENSION/PHENYLPROPANOLAMINE/CARDIOVASCULAR........ HYPOLIPIDEMIC/PEROXISOME/LIVER ...................................................... HYPOVOLEMIC SHOCK/BLOOD SUBSTITUTE/CARDIOVASCULAR HYPOXIA/GLUTATHIONE/OXIDATIVE STRESS........................................ HYPOXIA/ALCOHOL/KUPFFER CELLS........................................................ IBOGAINE HC1/PRECLINICAL TOXICITY STUDY/NEUROBEHAVIORAL IBOGAINE HC1/PRECLINICAL TOXICITY STUDY/NEUROBEHAVIORAL ICZ/CYTOCHROME P-450/BREAST CANCER CELLS ...................................... IDPN/DICHLOBENIL/OLFACTORY FUNCTION.......................................... IGA/SALIVA/BIOMARKERS....................................................................................... IGA NEPHROPATHY/VOMITOXIN/SEX HORMONES................................. IGE/NO2/DUSTMITE ....................................................................................... IGE/RESPIRATORY/HYPERSENSITIVITY.................................................... IGF-I RECEPTOR/CANCER/ESTROGEN........................................................ nB/HIA INHIBITOR/ANTICOAGULANT/ANTI-PLATELET......................... IL- I/OZONE/PERMEABILITY...................................................................................................................................................... IL-1BETA/TCDD/KERATINOCYTES........................................................................................................................................ IMMORTAJLIZED/PIM- 1/KERATINOCYTES ......................................................................................................................... IMMUNE/MACROPHAGES/METHADONE............................................................................................................................. IMMUNE CELLS/DELTA9-THC/CANNABINOID RECEPTOR .......................................................................................... IMMUNE FUNCTION/HOST-RESISTANCE/PYRIMETHAMINE..................................................................................... IMMUNE FUNCTION/TOXICITY/VCN.................................................................................................................................... IMMUNE SUPPRESSION/POLYCHLORINATED BIPHENYLS/LYMPHOKINES ...................................................... IMMUNE SYSTEM/SPECIES COMPARISON/MACROPHAGES ..................................................................................... IMMUNE SYSTEM/ETHANOL/ADRENALECTOMIZED .................................................................................................. IMMUNIZATION/RICIN/VACCINE.......................................................................................................................................... IMMUNIZATION/PULMONARY/PATHOLOGY .................................................................................................................. IMMUNOASSAY/TCDD/AH RECEPTOR ............................................................................................................................... IMMUNOCHEMISTRY/PROTEIN ADDUCTS/MENTHOFURAN..................................................................................... IMMUNOCYTOCHEMISTRY/GAP JUNCTIONS/CONNEXIN 43..................................................................................... IMMUNOENHANCEMENT/COCAINE/NEUROENDOCRINE......................................................................................... IMMUNOGENICITY/PRIMATE/PLASMINOGEN ACTIVATOR ..................................................................................... IMMUNOHISTOCHEMISTRY/P53/1,3-BUTADIENE ......................................................................................................... IMMUNOINHffimON/CYTOCHROME P-450/CHLORZOXAZONE.............................................................................. IMMUNOLOGY/SKIN/ULTRAVIOLET RADIATION ......................................................................................................... IMMUNOMODULATION/HALOGENATED HYDROCARBONS/FLOW CYTOMETRY ......................................... IMMUNOMODULATION/PREDNISOLONE/HOSTRESISTANCE ................................................................................ IMMUNOMODULATION/SOLVENTS/SKIN........................................................................................................................... IMMUNOMODULATION/LIDOCAINE/COCAINE................................................................................................................ IMMUNOMODULATION/ETHANOL/COCAINE.................................................................................................................. IMMUNOSUPPRESSANTS/CYTOTOXICITY/NEPHROTOXICITY................................................................................ IMMUNOSUPPRESSION/TCELL-INDEPENDENT RESPONSE/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN IMMUNOSUPPRESSION/IN VITRO/ACETAMINOPHEN.................................................................................................. IMMUNOSUPPRESSION/RISK ASSESSMENT/REGULATORY TOXICOLOGY........................................................ IMMUNOSUPPRESSION/MAA/SPECIES................................................................................................................................. IMMUNOSUPPRESSION/CYTOKINES/ETHANOL.............................................................................. ........................... IMMUNOSUPPRESSION/STRUCTURE ACTIVITY/POLYCYCLIC AROMATIC HYDROCARBONS................ IMMUNOSUPPRESSION/PROTEIN KINASE 02-ACETYLAMINOFLUORENE........................................................ IMMUNOSUPPRESSION/CALCIUM/SIGNALLING............................................................................................................. IMMUNOSUPPRESSION/APOPTOSIS/GLUCOCORTICOIDS ......................................................................................... IMMUNOSUPPRESSION/SERUM FACTOR/COCAINE....................................................................................................... IMMUNOSUPPRESSION/METABOLISM/COCAINE........................................................................................................... IMMUNOSUPPRESSION/CORTICOSTEROIDS/TRANSPLANTATION........................................................................ IMMUNOSUPPRESSION/T-2 TOXIN/HOST RESISTANCE .............................................................................................. 16)2 1488 1100 1477 611 1450 827 828 728 -.297 13 1247 -.417 1610 -.457 1489 1231 1509 .518 1398 1400 .409 413 ..17 .402 1397 .780 1669 1025 .365 .134 1242 .819 .520 .100 .478 ..19 .408 .412 1241 1243 .187 ..18 ...22 ..23 ,.403 .753 ..755 .946 ..952 .1158 .1240 .1244 .1249 .1404 IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMMUN IMPRO INUTE INUTE INUTE INVm iNvrn INVITI iNvrn INVITI iNvm INVITI INVITI INVITI INVITI INVITI INVITI iNvrr iNvrr INVIT IN VIT INVIT INVIT INVIT INvrr INVIT INVIT INVIT INVIT INVIT INVIT INVIT IN VIT INVIT IN VIT 510 5H904 0233 >612 >488 100 >477 611 >450 827 828 728 297 13 1247 417 1610 457 1489 >231 1509 .518 1398 1400 .409 .413 . .17 .402 1397 .780 1669 1025 .365 .134 1242 .819 .520 .100 478 .19 408 412 241 243 .187 . .18 . .22 ..23 .403 .753 .755 .946 .952 1158 1240 1244 1249 1404 IMMUNOSUPPRESSION/CATFISH/BIOMARKERS ..................................................................................................................................... 1654 IMMUNOTERATOLOGY/FETAL ALCOHOL SYNDROME/THYMUS....................................................................................................1245 IMMUNOTOXICITY/RISK ASSESSMENT/HAZARD IDENTIFICATION.................................................................................................477 IMMUNOTOXICITY/OZONE/MACROPHAGES................................................................................................................................................479 IMMUNOTOXICITY/SCID MOUSE/THYMUS .................................................................................................................................................. 480 IMMUNOTOXICITY/POLYCYCLIC AROMATIC HYDROCARBONS/PHOSPHORYLATION.........................................................947 IMMUNOTOXICITY/POLYCYCLIC AROMATIC HYDROCARBONS/CALCIUM ............................................................................... 951 IMMUNOTOXICITY/POLYCYCLIC AROMATIC HYDROCARBONS/CALCIUM ............................................................................... 953 IMMUNOTOXICITY/DOPAMINE ANTAGONIST/LEUKOCYTES .......................................................................................................... 1248 IMMUNOTOXICITY/RISK ASSESSMENT/DEXAMETHASONE...............................................................................................................1583 IMMUNOTOXICOLOGY/ULTRAVIOLET UGHT/BENZO(A)PYRENE ......................................................................................................14 IMMUNOTOXICOLOGY/MICE/PAHS...................... 16 IMMUNOTOXICOLOGY/LYMPHOCYTE/METALS-PESTICIDES ............................................................................................................401 IMMUNOTOXICOLOGY/ORGANOPHOSPHATES/ACETYLCHOLINESTERASE...............................................................................414 IMMUNOTOXICOLOGY/CYCLOSPORIN A/RISK ASSESSMENT............................................................................................................482 IMMUNOTOXICOLOGY/MYCOTOXIN/TCELL............................................................................................................................................. 756 IMMUNOTOXICOLOGY/IN VITRO METAL TOXICITY/CADMIUM....................................................................................................... 877 IMMUNOTOXICOLOGY/SILICONE/NATURAL KILLER CELLS............................................................................................................ 1250 IMMUNOTOXICOLOGY/METALS/FIS H........................................................................................................................................................... 1254 EMMUNOTOXICOLOGY/MEDAKA/HAZARD ASSESSMENT .................................................................................................................1254 IMMUNTOXICOLOGY/EPIDEMIOLOGY/HUMAN BIOMONTTORING...................................................................................................481 IMPROVED GRADES/EDUCATION/TEACHING/PERFORMANCE ENHANCEMENT ...................................................................... 286 IN UTERO AND LACTATIONAL/TCDD/SPERMATOGENESIS ...............................................................................................................1499 IN UTERO EXPOSURE/CHLORPYRIFOS/ACETYCHOLINESTERASE ...................................................................................................910 IN UTERO EXPOSURE/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN/THYMOCYTES .................................................................. 1500 IN VITRO/ACETAMINOPHEN/IMMUNOSUPPRESSION................................................................................................................................ 22 IN VITRO/METABOLISM/LIVER............................................................................................................................................................................ 26 IN VITRO/HALOGENATED HYDROCARBONS/HEPATOTOXiaTY ....................................................................................................... 32 IN VITRO/STRESS PROTEINS/LIVER SLICES....................................................................................................................................................33 IN VITRO/DIATOMS/SILICA....................................................................................................................................................................................142 IN VITRO/2-METHOXYETHANOL/TESTES.......................................................................................................... 264 IN VITRO/EYE/DRAIZE............................................................................................................................................................................................ 309 IN VITRO/CELL PROLIFERATION/CARCINOGENESIS ............................................................................................................................. 312 IN VITRO/NEOMYCIN/NEPHROTOXICITY...................................................................................................................................................... 317 IN VITRO/ARSINE/HEMOLYSIS .......................................................................................................................................................................... 320 IN VITRO/MACROPHAGES/PHOSPHOLIPIDOSIS .........................................................................................................................................330 IN VITRO/MACROPHAGES/PHOSPHOUPIDOSIS ......................... 332 IN VITRO/DERMATOTOXICOLOGY/PHOTOTOXICnY............................................................................................................................. 333 IN VITRO/SULFUR MUSTARD/DERMATOTOXICTTY.................................................................................................................................. 334 IN VITRO/ARACHIDONIC ACID/SKIN IRRITATION.................................................................................................................................... 335 IN VITRO/SKIN/CYTOCHROME P-450 ............................................................................................................................................................... 337 IN VITRO/CORROSIVITY MECHANISMS/DERMAL CORROSION..........................................................................................................344 IN VITRO/HUMAN SKIN/CORROSION............................................................................................................................................................... 345 IN VITRO/HUMAN SKIN/IRRITATION............................................................................................................................................................... 346 IN VITRO/HUMAN SKIN/PHOTOTOXICITY.................................................................................................................................................... 347 IN VITRO/DERMAL/TOXICITY ............................................................................................................................................................................ 350 IN VITRO/STRESS RESPONSE/TISSUE SPECIFICITY .................................................................................................................................. 447 IN VITRO/PENTAMIDINE/NEPHROTOXICnY............................................................................................................................................... 532 IN VITRO/GASTRIC SIMULATION/LEAD BIOAVAILABILITY................................................................................................................ 559 IN VITRO/HEPATOTOXICnY/GLUTATHIONE ............................................................................................................................................. 695 IN VITRO/AXONAL TRANSPORT/NEUROTOXICOLOGY ......................................................................................................................... 758 IN VITRO/ANTICHOLINESTERASE/BIOACnVATION................................................................................................................................905 IN VTTRO/ECETOC CHEMICALS/EYE IRRITATION .................................................................................................................................... 986 IN VITRO/DRAIZE/EYE............................................................................................................................................................................................ 987 IN VITRO/CONTINUOUS DOSING/TCDD .......................................................................................................................................................1048 511 511904 0234 IN VTTRO/HALOCARBON/METABOLISM................................................................................................................................................... INVITRO/POLYCYCLICAROMATICHYDROCARBONS/TCDD .................................................................................................... ,5 IN VITRO/ALLERGY/CYTOKINES ................................................................................................................................................................ ', 6, IN VITRO/MARINE MAMMAL/HYDROCARBON...................................... 164J IN VITRO/MARINE MAMMAL/HYDROCARBON...................................... ...................... ................................................................... I646 IN VITRO/AQUATIC/SURFACTANTS............................................................................................................................................................... !649 IN VITRO ALTERNATIVES/OCULAR IRRITATION/EYE ...........................................................................................................................9gg IN VITRO ASSAY/LIVER/TRANSCRIPTION ................................................................................................................................................... 3u IN VITRO ASSAYS/PULMONARY/DUSTS..................................................................................................................................................... I47 IN VITRO BACTERIAL ASSAY/NICKEL/TOXICITY ................................................................................................................................... 90, IN VITRO METABOLISM/KIDNEY PROXIMAL TUBULAR CELLS/19F-N. M. R............................................................................... ,97 IN VITRO METAL TOXICITY/CADMIUM/IMMUNOTOXICOLOGY.......................................................................................................877 IN VITRO METHODOLOGY/RISK ASSESSMENT/SKIN PERMEABILITY........................................................................................... 342 IN VITRO SYSTEMS/CHEMICAL BINDING....................................................................................................................................................1568 IN VITROTESTING/TOXICITY/CELL PROLIFERATION ...........................................................................................................................3l6 IN VITRO TESTING/ACRYLAMIDE/GROWTH FACTORS ....................................................................................................................... 1360 IN VITRO TOXICOLOGY/SKIN MODEL/PERCUTANEOUS ABSORPTION......................................................................................... 349 IN VITRO TOXICOLOGY/RICIN/PSEUDOMONAS........................................................................................................................................782 IN VITRO TOXICOLOGY/FREE RADICAL SCAVENGERS/PARAQUAT ............................................................................................ 1525 IN VTVO/GENOTOXICITY/MICRONUCLEUS ................................................................................................................................................1272 IN VIVO/OLEFINS/MICRONUCLEUS ............................................................................................................................................................... 1277 IN VIVO COVALENT BINDING/ACETAMINOPHEN/NEPHROTOXICITY............................................................................................ 195 IN VIVO TOXICOLOGY/DNA DAMAGE/SINGLE CELL GEL........................................................................................................................ 9 IN VIVO/IN VITRO/TOXICOKINETICS/ETHYLENE OXIDE...................................................................................................................... 384 IN VIVO/IN VITRO/MUTAGENICITY/VITAMIN B15....................................................................................................................................846 IN-VITRO/GLUTATHIONE/ACRYLATES.......................................................................................................................................................... 659 INBORN ERROR OF METABOLISM/TYROSINAEMIA/4-HYDROXYPHENYLPYRUVATE DIOXYGENASE.........................826 INCINERATIONAL HEALTH RISKS/MUNICIPAL SOLID WASTE .........................................................................................................552 INDIUM/INHALATION/INFLAMMATION...................................................................................................................................................... 1021 INDIUM ARSENIDE/RENAL ACTIVITY/GALLIUM ARSENIDE ............................................................................................................1018 INDOLE COMPOUNDS/CHEMOPROTECTTON/MOLECULAR MODELING........................................................................................... 44 INDOLE-3-CARBINOL/AFLATOXIN B i/BETA-NAPHTHOFLAVONE...................................................................................................... 42 INDOLE-3-CARBINOL/AFLATOXIN B 1/GLUTATfflONE S-TRANSFERASE YC2 ..............................................................................43 INDOOR AIR/SENSORY IRRITATION/LOW LEVEL VOC EXPOSURE.................................................................................................. 968 INDUCED CATFISH/INTESTINAL BIOTRANSFORMATION/BENZO(A)PYRENE .......................................................................... 1708 INDUCERS/SMALL INTESTINE/CYTOCHROME P-450 ............................................................................................................................... 491 INDUCTION/DIET/DETOXinCATION ENZYMES .......................................................................................................................................... 49 INDUCTION/CYTOCHROME P-45G/HEPATOCYTES.................................................................................................................................... 123 INDUCTION/MICE/CYTOCHROME P-45&........................................................................................................................................................ 126 INDUCTION/CYTOCHROME P-45Q/CELL CULTURE .................................................................................................................................. 129 INDUCTION/CYP1A2/POLYCYCLIC AROMATIC HYDROCARBONS ................................................................................................. .496 INDUCTION/LIVER/ENZYMES ............................................................................................................................................................................704 INDUCTION/METALLOTHIONEIN/TRANSGENIC........................................................................................................................................ 890 INDUCTION/SULFOTRANSFERASE/STEROID............................................................................................................................................. 1328 INDUCTION/BENZO(A)PYRENE/BIOAVAILABILITY................................................................................................................................ 1709 INDUCTIONS/DIET/DETOXmCATION ENZYME .......................................................................................................................................... 50 INFECTION/CHLOROFORM/TRICHLOROETHYLENE............................................................................................................................... 418 INFLAMMATION/STRAIN DIFFERENCES/OZONE ...................................................................................................................................... 274 INFLAMMATION/LAVAGE/NEUTROPHILS................................................................................................................................................... 276 INFLAMMATION/SILICA/MUTATION...............................................................................................................................................................278 INFLAMMATION/METALLOTHIONEIN/DIMETHYLNITROSAMINE .................................................................................................. 443 INFLAMMATION/SILICA/CYTOKINES .............................................................................................................................................................751 INFLAMMATION/TRANSGENIC/CHEMOKINE.............................................................................................................................................945 INFLAMMATION/INDIUM/INHALATION...................................................................................................................................................... 1021 INFL INFL INFU INFU INFU INFU INFU INFU INH/ lNH/> INH/ INH/ INH> INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH/ INH. INH INH INH INH INH INH INH INH INH INH INH INH INH INH INH INH INH INH 511904 1068 1308 1514 1613 1645 1646 1649 .988 314 147 .901 .197 .877 342 1568 .316 1360 .349 .782 1525 1272 1277 .195 . . .9 .384 .846 .659 .826 .552 1021 1018 . .44 . .42 . .43 .968 1708 191 .49 123 126 129 496 .704 .890 1328 1709 . .50 .418 .274 .276 .278 .443 .751 .945 1021 INFLUENZA VIRUS/TCDD/NATURAL KILLER ACTIVITY ......................................................................................................................1515 INFLUENZA VIRUS/OVALBUMIN/HYPERSENSnTVTTY.......................................................................................................................... 1612 INFUSION/RATS/BODYWElGHT...........................................................................................................................................................................860 [NFUSION/RATS/TERATOLOGY........... ........................................................................................................................................................... 861 INFUSION/METHODOLOGY/INTRAVENOUS ................................................................................................................................................863 INFUSION/MOUSE/SALINE ....................................................................................................................................................................................865 I INFUSION/DOG/BODYWElGHT............................................................................................................................................................................. 867 ! INFUSION/CONTINUOUS/DOG............................................................................................................................................................................. 868 j INHALATION/HUMORAL IMMUNITY/CARBARYL ........................................................................................................................................15 ! INHALATION/CHLOROFORM/RATS .................................................................................................................................................................. 178 j INHALATION/ISOPROPANOL/NEUROTOXICITY......................................................................................................................................... 304 j INHALATION/CELL PROLIFERATION/CHLOROFORM..............................................................................................................................435 INHALATION/RISK ASSESSMENT/VOLATILE ORGANIC COMPOUNDS............................................................................................ 547 INHALATION/DEVELOPMENTAL/SILOXANE................................................................................................................................................572 INHALATION/LIVER EFFECTS/OCTAMETHYLCYCLOTETRASILOXANE ........................................................................................698 INHALATION/SMOKE/HISTOPATHOLOGY.................................................................................................................................................... 721 INHALATION/AMILORIDE/CYSTIC FIBROSIS................................................................................................................................................830 INHALATION/CARCINOGENICITY/BERYLLIUM....................................................................................................................................... 1011 INHALATION/INFLAMMATION/INDIUM.......................................................................................................................................................1021 INHALATION/THERMAL EMISSIONS/SENSORY IRRITATION ............................................................................................................ 1205 INHALATION/THERMAL EMISSIONS/SENSORY IRRITATION ............................................................................................................ 1206 INHALATION/ACUTE/ALIPHATIC AMINES............................... 1214 INHALATION/STRUCTURE ACTIVITY RELATIONSHIPS/ALKOXYSILANES................................................................................. 1215 INHALATION/ONCOGENICITY/ISOPROPANOL............................................................................................................... 1219 INHALATION/ONCOGENICITY/METHYLETHYLKETOXIME................................................................................................................. 1220 INHALATION/NASAL IRRITATION/CHLORINE ..........................................................................................................................................1221 INHALATION/COMMERCIAL HEXANE/CHRONIC TOXICITY...............................................................................................................1233 I INHALATION/NEUROTOXICITY/4-PHENYLCYCLOHEXENE ...............................................................................................................1237 j INHALATION/SUBCHRONIC TOXICITY/CUMENE.....................................................................................................................................1238 ; INHALATION/SULFURYL FLUROIDE/ONCOGENICITY ..........................................................................................................................1547 ; INHALATION/HEXAMETHYLENE DIISOCYANATE/ADAPTION.......................................................................................................... 1589 ! INHALATION/ARSINE/ANEMIA.........................................................................................................................................................................1590 INHALATION/LIQUID AEROSOLS/ACUTE.................................................................................................................................................... 1661 , INHALATION/PERCHLOROMETHYL MERCAPTAN/FOLPET TECHNICAL......................................................................................1662 INHALATION/FIBERS/CARCINOGENICS...................................................................................................................................................... 1665 INHALATION/SUPERABSORBENTS/SWELLING PARTICLES ...............................................................................................................1675 INHALATION/FIBROSIS/DISPOSITION...........................................................................................................................................................1716 INHALATION EXPOSURE/PULMONARY SURFACTANT/CIGARETTE SMOKE............................................................................. 1679 INHALATION EXPOSURES/AUTOMATED EXPOSURES/EXPOSURE CONTROL............................................................................. 157 INHALATION TOXICITY/PCBTF/HEPATOCYTE HYPERTROPHY........................................................................................................ 1213 INHALATION TOXICOLOGY/AEROSOL/CANINE EXPOSURE................................................................................................................. 158 I INHALATION TOXICOLOGY/FIBROUS AEROSOL/POTASSIUM OCTATTTANATE...................................................................... 1672 INHALATION/AEROSOL/TOXICrTY/RICIN.......................................................................................................................................................145 INHALATION/AEROSOL/TOX3CITY/BOTULINUM..................................................................................................................................... 1670 INHALATION/AEROSOL/TOXICITY/SEB .......................................................................................................................................................1671 INHALATION/NOSE ONLY EXPOSURE/CORE BODY TEMPERATURE/ANIMAL RESTRAINT.................................................. 866 INHALATION/WHOLE BODY EXPOSURE/INHALED DOSE/CHLOROFORM....................................................................................1202 INHALED DOSE/CHLOROFORM/INHALATION/WHOLE BODY EXPOSURE....................................................................................1202 ! INHIBITION/HYDROXYL RADICAL/DENTIFRICE .......................................................................................................................................602 1 INHIBITION/AMPHIPHILIC DRUGS/NITRIC OXIDE.................................................................................................................................... 736 INHIBITION/NITRIC OXIDE SYNTHASE/METALS .......................................................................................................................................737 INHIBITION/PESTICIDES/NITRIC OXIDE SYNTHASE ................................................................................................................................738 INHIBITION/REACTIVATION/ACETYLCHOLINESTERASE.....................................................................................................................904 INHIBITION/FLAVONE/CYTOCHROME P-450 .............................................................................................................................................. 1036 INHIBinON/AURINTRICARBOXYLIC ACID/ENZYME ............................................................................................................................1493 513 511904 0236 INITIATION/PROMOTION/DIETHYL/DIMETHYL-PHTHALATE/PEROXISOMEPROLIFERATORS ........................ INOSITOL POLYPHOSPHATES/PHENCYCLIDINE/MK 801 .............................................................................................. 1,70 INSECTICIDAL PLANTS/BENEFICIAL PLANTS/NONTARGET ORGANISMS ............................................................ " ' " 804 INSITOLTRISPHOSPHATE/CYANIDE/METABOTROPICRECEPTORS.............................................................................. if6 INSULIN-LIKE GROWTH FACTOR/PHARMACOKINETICS/AMYOTROPHIC LATERAL SCLEROSIS .................. 242 INSULIN-LIKE GROWTH FACTOR/SAFETY/AMYOTROPHIC LATERAL SCLEROSIS ................................................. " "' 27 INTER-LABORATORY VALIDATION/FETAX/DEVELOPMENTAL TOXICITY ................................................................... 28 INTERACTION/COMBINATION TOXICOLOGY/MIXTURES...................................................................................................... ' , IT INTERACTIONS/MOTOR ACTIVITY/PESTICIDES............................................................................................................ 4 .... ... . ..... .............. . INTERACTTVE/HEPATOTOXICITY/DICHLOROBENZENE................................................................................................................. 70, INTERFACIAL TRANSFER/NITROGEN DIOXIDE/SURFACTANTS ........................................................................................... 150 INTERFERON-GAMMA/TNF/ENDOTOXIN............................................................................................................................................ ' 944 INTERLEUKIN/MYCOTOXIN/GENE EXPRESSION............................................................................................................................... ?57 INTERLEUKIN 4/CHEMICAL ALLERGENS/LYMPH NODE CELLS ................................................................................................. ..... INTERLEUKIN-1/CELL ADHESION ASSAY/ENDOTHELIAL CELLS ............................................................................................... 3I, INTERLEUKIN-1/GENE EXPRESSION/RADIATION.................................................................................................................................. .. INTERLEUKIN-1 RECEPTOR ANTAGONIST/RATS/REPRODUCTION................................................................................................... INTERLEUKIN-1 RECEPTOR ANTAGONIST/HOST RESISTANCE/BACTERIAL CHALLENGE................................................. 1403 INTERLEUKIN-12/TOXICITY/CYTOKINE..................................... g20 INTERLEUKIN-3/CYTOTKINE/COLONY SIMULATING FACTOR ......................................................................................................1556 INTERLEUKIN-6/GLOMERULONEPHRmS/CYCLOSPORINE................................................................................................................1402 INTERLEUKINS/GENE EXPRESSION/TRICHOTHECENES ......................................................................................................................754 INTESTINAL BIOTRANSFORMATION/BENZO(A)PYRENE/INDUCED CATTISH ..........................................................................170g INTESTTNE/PROTOCOLS/TRANSGENE..............................................................................................................................................................10 INTRACELLULAR CALCIUM/CORNEAL EPITHELIAL CELLS/FLUORESCENCE RATIO IMAGING ..................................... 356 INTRACELLULAR CALCIUM/HEART CELL CULTURES/ANABOLIC-ANDROGENIC STEROIDS.......................................... 1474 INTRACELLULAR CALCIUM/NEUROTOXICITY/METHYLMERCURY..............................................................................................1494 INTRACELLULAR PH/CORNEAL EPITHELIUM/FLUORESCENCE RATIO IMAGING ..................................................................357 INTRANASAL DOSING/DOSE DISTRIBUTION PATTERN/METHOD VALIDATION....................................................................... 156 INTRATRACHEAL/PARTICLES/RATS.............................................................................................................................................................. 154 INTRAVENOUS/INFUSION/METHODOLOGY .............................................................................................................................................. 863 INTRAVENOUS INFUSION/TEMPERATURE/REPRODUCnVE PERFORMANCE ........................................................................... 221 INVERTEBRATE/DIOXIN/RECEPTORS.......................................................................................................................................................... 1027 IODINATED/NANOPARTICLE/X-RAY CONTRAST..................................................................................................................................... 833 IODINATED NANOPARTICLES/X-RAY CONTRAST................................................................................................................................... 834 ION HOMEOSTASIS/2.5-HEXANEDIONE/NEUROTOXICITY ................................................................................................................. 760 IP3/CALCIUM/CAGED CALCIUM MEDIATORS.......................................................................................................................................... 1497 IRON/CHELATORS/PROTOPORPHYRIA ........................................................................................................................................................ U02 IRON/FREE RADICALS/LIPID PEROXIDATION.......................................................................................................................................... 1580 IRON INTAKE/BLOOD LEAD/CHILDREN....................................................................................................................................................... 257 IRON OVERLOAD/SPLEEN/UNOLEIC ACID ANILIDE............................................................................................................................. 1557 IRRITANCY/GLUTARALDEHYDE/ACUTETOXICITY...............................................................................................................................672 IRRITANT/OFFGASSING/CARPETS .................................................................................................................................................................. 966 IRRITATION/EYE/BCOP......................................................................................................................................................................................... 310 IRRITATION/IN VITRO/HUMAN SKIN.............................................................................................................................................................. 346 IRRITATION/CARPETS/MIXTURES .................................................................................................................................................................973a IRRITATION/CORNEAL THICKNESS/EYE .................................................................................................................................... 984 ISCHEMIA/REPERFUSION/VIABILITY/CARDIAC MYOCYTES ..............................................................................................................308 ISOCYANATES/REFERENCE CONCENTRATION/RESPIRATORY....................................................................................................... 1594 ISOFENPHOS METABOLISM/CYTOCHROME P-450 INDUCTION/CHOLINESTERASE INHIBITION ...................................... 700 ISOLATED PERFUSED LIVER/EPOXIDE HYDROLASES/GLUTATHIONE CONIUGATION ........................................................956 ISOLATED PERFUSED TUBULE/BASOLATERAL HG TRANSPORT/PROXIMAL TUBULE.......................................................... 996 ISOLATED RENAL CELLS/CYTOTOXICITY/SUCCINIMIDE.................................................................................................................... 176 (SOLA' J5OM.4 i5ON1/ ,SOPRl j$OPR< |SOPR< 1SOPR' ISOTH ISOTH ISOZY JACKE jACOE jUGUI jCALLl KERA' KERA' KERA' KERA' KERA' KERA' keta: kevl kidni KIDN1 kidni KIDNI KIDNI KIDNI KIDNI KIDNI KIDNI KIDNI KIDNI KIDNI KIDN KIDN KIDN KIDN KINE KINF KINE KINE KINE KINE KINE KINE KUPf KUPf KUPI KUPI KUPI KUPI KUPI KUPI KUPI 511904 0237 ISOLATED. PERFUSED LUNG/REACTTVITY/TOLUENE DIISOCYANATE (TDD..............................................................................1.239 ISOMALATHION/ACETYLCHOLINESTERASE/NEUROTOXICESTERASE ........................................................................................ 911 1SONIAZID/CYTOCHROMEP450/CYP2E1 ....................................................................................................................................................... 1302 1SOPRENE/CARCINOGENESISmJMOR DEVELOPMENT ................................................................................................................ 469 [SOPROPANOL/NEUROTOXICITY/INHALATION......................................................................................................................................... 304 [SOPROPANOL/INHALATION/ONCOGEN1CITY ......................................................................................................................................... 1219 ' [SOPROPANOL/HEPATOCELLULAR REGENERATION/LIVER INJURY.............................................................................................1448 ! [SOTHIAZOLONES/LYMPH NODE CELL PROLIFERATION/CONTACT HYPERSENSITIVITY...................................................1262 ; [SOTHIOCYANATE/PROTEIN ADDUCT/METHYL DITHIOCARBAMATE ........................................................................................ 1697 ISOZYME-SELECTIVE/l-AMINOBEZOTRIAZOLEDERIVATTVES/METABOLIC INTERMEDIATE COMPLEX.............. .. .108 JACKETS/TOXICITY PARAMETERS/DERMAL ............................................................................................................................................. 674 JACOBINE/CARBOXYLESTERASE/PYRROLIZIDINE ALKALOID........................................................................................................1299 JUGULAR VEIN/RATS/BLEEDING ...................................................................................................................................................................... 862 KALLIKREIN/VANCOMYCIN/NEPHROTOXICITY....................................................................................................................................... 174 ! KERATINOCYTES/UV/CYTOKINES....................................................................................................................................................................339 KERATINOCYTES/CELLCYCLE/BIS-(2-CHLOROETHYL)-SULFIDE ...................................................................................................352 \ KERATINOCYTES/DIFFERENTIATION/BIS-(2-CHLOROETHYL)SULFIDE........................................................................................353 j KERATINOCYTES/IMMORTALIZED/PIM-1 ....................................................................................................................................................518 ! KERATINOCYTES/IL-1BETA/TCDD..................................................................................................................................................................1509 i KERATINOCYTES/TCDD/PROTEASES ...........................................................................................................................................................1627 ! KETAMINEL ANESTHESIA/CADMILRvVVERAPAMIL/HEPATIC CYTOCHROME P450 ................................................................. 878 j KEVLAR ARAMID/CELLPROLIFERATION/CHRYSOTTLE ASBESTOS...............................................................................................1668 j KIDNEY/CYTOCHROME P-450 2E1/DIMETHYLSULFOXIDE ................................................................................................................... 119 | KIDNEY/CHELATORS/METALS ...........................................................................................................................................................................184 KIDNEY/CHLOROFORM/CYTOCHROME P-450 2E1 .....................................................................................................................................199 ! KIDNEY/COVALENT ADDUCTS/HYDROQUINONE.................................................................................................................................... 201 : KIDNEY/LEAD/METAL-BINDING PROTEINS................................................................................................................................................. 254 KIDNEY/CELL PROLIFERATION/HYDROQUINONE ..................................................................................................................................437 KIDNEY/FUMONISDOTOXICITY..........................................................................................................................................................................774 KIDNEY/RABBIT/FUMONISIN.............................................................................................................................................................................. 775 KIDNEY/ALPHA2U-GLOBULIN/GLYCOSAMINOGLYCAN.......................................................................................................................816 KIDNEY/LETHAL CELL INJURY/LIVER .......................................................................................................................................................... 927 KIDNEY/CELL DEATH/PHOSPHOLIPASE A2................................................................................................................................................. 929 KIDNEY/ALA SYNTHETASE MRNA/MERCURY.........................................................................................................................................1186 KIDNEY LESIONS/DEET/ALPHA 2U-GLOBULIN........................................................................................................................................... 175 KIDNEY PROXIMAL TUBULAR CELLS/I9F-N. M. R7IN VITRO METABOLISM...............................................................................197 KINESIN/AXONAL TRANSPORT/ACRYLAMIDE.......................................................................................................................................... 766 KINETICS/LEAD/PREGNANCY............................................................................................................................................................................220 KINETICS/CHILD/LEAD ISOTOPES ................................................................................................................................................................... 260 KINETICS/HYDROQUINONE/PHENOLS .......................................................................................................................................................... 391 KINETICS/SKIN ABSORPTION/ETHYLENE OXIDE...................................................................................................................................... 667 KINETICS/CADMIUM/ROS 17/2.8 ........................................................................................................................................................................870 KINETICS/SELENIUM/SELENOPROTEIN ...................................................................................................................................................... 1010 KINETICS/TRICHLOROETHYLENE/METABOLISM .................................................................................................................................. 1082 KUPFFER CELL/TUMOR NECROSIS FACTOR/PCB.....................................................................................................................................1064 KUPFFER CELLS/TUMOR NECROSIS FACTOR/ENDOTOXIN.................................................................................................................. 247 KUPFFER CELLS/REPERFUSION INJURY/LIPID PEROXIDATION......................................................................................................... 626 KUPFFER CELLS/GLUTATHIONE/ENDOTOXIN ...........................................................................................................................................645 KUPFFER CELLS/HYPOXIA/ALCOHOL...........................................................................................................................................................1450 KUPFFER CELLS/OXYGEN CONSUMPTION/ALCOHOL ..........................................................................................................................1453 KUPFFER CELLS/SUPEROXIDE/DICHLOROBENZENE ............................................................................................................................1467 KUPFFER CELLS/CARBON TETRACHLORIDE/METHANOL .................................................................................................................1470 KUPFFES CELLS/NEUTROPHILS/ENDOTOXIN........................................................................................................................................... 1452 SI 5 511904 0238 L-DOPA/CYTOTOXICITY/MANGANESE............................................................................................................................................... L-DOPA/COMT INHIBfTOR/DRUG INTERACTTON/CYNOMOLGUS MONKEYS............................................................ LABELING INDEX/FORESTOMACH/STYRENE OXIDE ............................................................................................................... ' 13 LABELLING INDEX/ADRENERGIC/CELL PROLIFERATION ......................................................................................... .......... LAMIN A/ACETAMINOPHEN:COVALENT BINDING/NUCLEO TRANSLOCATION OF ADDUCTS................................... , LAMININ/SULFUR MUSTARD/ALKYLATION................................................................................................................................. ' ' ", ' LANDFILUMEDAKA/LEACHATE............................................................................................................................................................. ' LANGERHANS CELLS/ANTIGEN PRESENTATION/HUMAN .........................................................................................................'" ^ LANGERHANS CELLS/SKIN SENSITIZATION/TUMOR NECROSIS FACTOR ....................................................................... -1605 LASER CONFOCAL MICROSCOPE/CYTOCHROME P-450 INDUCTION/MOLECULAR PROBE.......................................... 3lJ LASER CYTOMETRY/MITOCHONDRIA/RHODAMINE 123............................................................................................................... 3] LASER CYTOMETRY/GLUTATHIONE S-TRANSFERASE/GLUTATHIONE ..............................................................................' ' "^ LASER CYTOMETRY/CYTOTOXICITY/FLUORESCENCE PROBES............................................................................................ ' 77g LASER-SCANNING CONFOCAL MICROSCOPY/POLYCHLORINATED BIPHENYLS/TYROSINE HYDROLAYSE.......... 1372 LATENCY TIME/DOSE-RESPONSE/SKIN TUMOR....................................................................................................................................... .. LATENCY TIME/DNA DAMAGE/CELL PROLIFERATION......................................................................................................................1282 LAVAGE/NEUTROPHILS/INFLAMMATION.................................................................................................................................................. 276 LAZAROID U 74389F (ANTIOXIDANT)/ENDRIN/NEUROTOXICITY.................................................................................................. 1355 LDH/VCN/TESTES ....................................................................................................................................................................................................268 LDH ISOENZYMES/NEPHROTOXICITY/URINARY MARKERS ............................................................................................................. 173 LEACHATE/LANDFILL/MEDAKA..................................................................................................................................................................... 1640 LEAD/MICROSWINE/BIOAVAILABILITY....................................................................................................................................................... 560 LEAD/PREGNANCY/PHARMACOKINETICS.....................................................................................................................................................54 LEAD/PHARMACOKINETIC MODELS/RISK ASSESSMENT ..................................................................................................................... 55 LEAD/TOXICOKINETIC MODELS/RISK ASSESSMENT .............................................................................................................................. 56 LEAD/EXPOSURE/SMELTER EMISSIONS......................................................................................................................................................... 58 LEAD/PREGNANCY/KINETICS........................................................................................................................................................................... 220 LEAD/CALCIUM/OSTEOCALCIN .......................................................................................................................................................................248 LEAD/NEURONS/CALCIUM.................................................................................................................................................................................. 249 LEAD/GLUTAMATE/EXCITOTOXICITY......................................................................................................................................................... 250 LEAD/NMDA RECEPTOR/ZINC...........................................................................................................................................................................251 LEAD/GLUCOCORTICOID EFFECTS/HEPATOMA CELLS........................................................................................................................252 LEAD/HEME PATHWAY PARAMETERS/BIOMARKERS .......................................................................................................................... 253 LEAD/METAL-BINDING PROTEINS/KIDNEY................................................................................................................................................ 254 LEAD/REPRODUCTIVE TOXICITY/DISRUPTED PUBERTAL GROWTH............................................................................................. 256 LEAD/METAL-BINDING PROTEINS/BRAIN...................................................................................................................................................302 LEAD/ABSORPTION/SWINE.................................................................................................................................................................................. 395 LEAD/ABSORFTION/SWINE.................................................................................................................................................................................. 3% LEAD/HIPPOCAMPAL NEURONS/PROTEIN KINASES...............................................................................................................................501 LEAD/MUSCARINIC RECEPTOR/HIPPOCAMPUS........................................................................................................................................502 LEAD/PROTEIN KINASE C/HIPPOCAMPUS ...................................................................................................................................................503 LEAD/CANCER POTENCY/STOCHASTIC MODELING............................................................................................................................... 543 LEAD/MICROSWINE/BIOAVAILABILITY....................................................................................................................................................... 560 LEAD/MINE-ORES/BIOACCUMULATION....................................................................................................................................................... 561 LEAD/PHARMACOKINETIC MODELS/ABSORPTION................................................................................................................................. 562 LEAD/FOLK-MEDICINES/AZARCON................................................................................................................................................................ 896 LEAD/ERYTHROPOIETIN/ANEMIA...................................................................................................................................................................897 LEAD/MACROPHAGES/PHAGOCYTOSIS....................................................................................................................................................... 898 LEAD/MACROPHAGES/EICOSANOID.............................................................................................................................................................. 899 LEAD/ANION/CALCIUM......................................................................................................................................................................................... 903 LEAD/FLOW CYTOMETRY/T-LYMPHOCYTES............................................................................................................................................ 949 LEAD/CATTLE/CHELATORS.............................................................................................................................................................................. 1001 LEAD/NEOMYCIN/DMSA..................................................................................................................................................................................... 1002 LEAD/NEUROTOXICITY/AUTOANTIBODY..................................................................................................................................................M 17 LEAD/NEUROTOXICITY/AUTOANTIBODY..................................................................................................................................................1119 leai LEA! LEA] leai leaj lea: lea LEA LEA LEA LEA LEA LEA LEA les: LET LEU LEU LEU LEU LEY LID' Lin LIM LIN LIN LIN LIN LIN L1P1 LIPJ LIP) LIP1 LIP! LIP LIP LIP LIF LIF LIF LII LIF LIF LIC LIT LIT LIT LIN LIN LIN LD LI' LI' LI' LI' 511904 0239 LEAD/RETINA/PHOSPHODIESTERASE...................................................................................................................................... 1121 LEAD/SODIUM-POTASSIUM A7PASE/RETINA.........................................................................................................................1122 LEAD/RETINA/APOPTOSIS ..........................................................................................................................................................1123 LEAD/GLIAL/GENE EXPRESSION ............ 1125 LEAD/BRAIN/SEROTONIN........................................................................................................................................................... 1126 LEAD/BRAIN/DOPAMINE............................................................................................................................................................. 1127 LEAD/VITAMIN D RECEPTOR/OSTEOCALCIN ........................................................................................................................ 1183 LEAD/MENOPAUSE/PREGNANCY..............................................................................................................................................1385 LEAD (PB)/TCDD/GAP JUNCTIONS ..............................................................................................................................................137 LEAD BIOAVAILABILITY/IN VITRO/GASTRIC SIMULATION.................................................................................................559 LEAD ISOTOPES/KINETICS/CHILD ............................................................................................................................................. 260 LEAD TOXICITY/LEAD-GLAZED CERAMICS/MEXICO............................................................................................................ 895 LEAD-GLAZED CERAMICS/MEXICO/LEAD TOXICITY............................................................................................................ 895 LEARNING/NEUROTOXICITY/TRIMETHYLTIN........................................................................................................................303 LESIONS/DINITROBENZENE/AUDITORY PATHWAY.............................................................................................................1342 LETHAL CELL INJURY/LIVER/KIDNEY ..................................................................................................................................... 927 LEUKEMIA/MAMMARY TUMORS/NEPHROPATHY................................................................................................................ 1175 LEUKOCYTESAMMUNOTOXICITY/DOPAMINE ANTAGONIST ........................................................................................... 1248 LEUKOTRIENES/HEPATORENAL/CYCLOSPORIN A ................................................................................................................815 LEUKOTRIENES/LIVER/A-NAPATHYLISOTHIOCYANATE...................................................................................................1440 LEYDIG CELL TUMORS/PANCREATIC ACINAR CELL TUMORS/PEROXISOME PROLIFERATORS................................1169 LIDOCAINE/COCAINE/IMMUNOMODULATION.............................................. 1241 LIFE-CYCLE-STAGES/MEDAKA/HISTOPATHOLOGY.............................................................................................................1632 LIMB CULTURE/RETINOIC ACID RECEPTOR/RETINOID........................................................................................................ 593 LINDANE/CONNEXIN43/GAP JUNCTIONS..................................................................................................................................132 LINDANE/UTERINE CONTRACTION/CYCLIC AMP ..................................................................................................................225 LINDANE/DERMAL DISTRIBUTION/VEHICLE EFFECTS ........................................................................................................ 338 LINDANE/HIPPOCAMPAL NEURONS/GABA-A CHLORIDE CHANNELS............................................................................... 507 LINOLEIC ACID ANILIDE/IRON OVERLOAD/SPLEEN............................................................................................................ 1557 LIPID/LIVER/ANXIOLYTIC .........................................................................................................................................................1107 LIPID COMPLEX/AMPHOCILTM/DEVELOPMENTAL TOXICITY...............................................................................................573 LIPID METABOLITES/CHROMIUM SALTS/OXIDATTVE STRESS........................................................................................... 1004 LIPID PEROXIDATION/CELL INJURY/PROPYLENE GLYCOL .................................................................................................164 LIPID PEROXIDATION/CALCIUM/ANTIOXIDANT....................................................................................................................621 LIPID PEROXIDATION/KUPFFER CELLS/REPERFUSION INJURY...........................................................................................626 LIPID PEROXIDATION/GAS CHROMATOGRAPHY/ANALYSIS.............................................................................................. 629 LIPID PEROXIDATION/IRON/FREE RADICALS.................................... 1580 LIPID PEROXIDATION AND EXERCISE/OXIDATIVE INJURY/METHEMOGLOBINEMIA .................................................. 627 LIPOCYTE/SCREEN/ANTIFTBROGENIC/ANTICIRRHOTIC...................................................................................................... 313 LIPOPOLYS ACCHARIDE/PROSTAGLANDIN/BEHAVIOR........................................................................................................ 291 LIPOSOME/TOXICITY/DOXORUBICIN....................................................................................................................................... 812 LIPOSOME/PHARMACOKINETICS/DISPOSITION/DOXORUBICIN......................................................................................... 813 LIPOXYGENASE/HUMAN PLACENTA/AFLATOXIN Bi.......................................................................................................... 1292 LIQUID AEROSOLS/ACUTE/INHALATION............................................................................................................................... 1661 LITHIUM/TERATOLOGY/DEVELOPMENTAL TOXICITY ........................................................................................................ 577 LITHIUM/LITHIUM PERFLOUROOCTANE SULFANATE/DEVELOPMENTAL TOXICITY.................................................... 578 LITHIUM PERFLOUROOCTANE SULFANATE/DEVELOPMENTAL TOXICITY/LITHIUM.....................................................578 LIVER/IN VITRO/METABOLISM.....................................................................................................................................................26 LIVER/CADMIUM/ANTICARCINOGENIC..................................................................................................................................... 38 LIVER/ERYTHROMYCIN/CYTOCHROME P-450 ......................................................................................................................... 99 LIVER/NITRIC OXIDE/OZONE.......................................................................................................................................................245 LIVER/TRANSCRIPTION/IN VITRO ASSAY ............................................................................................................................... 314 LIVER/CELL PROLIFERATION/CARCINOGENESIS .......................................................................................... 424 LIVER/PLATELETS/ENDOTOXIN................................................................................................................................................. 682 LIVER/CELL DEATH/FATTY ACID............................................................................................................................................... 684 517 511904 0240 liver/sevoflurane/metabolism.............. LIVER/ENZYMES/INDUCTION........ .............. LIVER/MITOCHONDR1A/B-OXIDATION.......... LIVER/FLUORESCENCE SPECTROSCOPY/CCI4 LIVER/METALLOTHIONEIN/ZINC................... LIVER/KIDNEY/LETHAL CELL INJURY .......... LIVER/MITOCHONDRIAL PERMEABILITY TRANSITIO/CELL DEATH............................. LIVER/CELL DEATH/NTTRIC OXIDE SYNTHASE.................................................................. LIVER/DI-(2-ETHYLHEXYL)ADIPATE/PEROXISOME PROLIFERATION........................... LIVER/CARCINOGENESIS/CELL PROLIFERATION/GENOTOXICITY................................. LIVER/HYPOLIPIDEMIC/PEROXISOME ................................................................................. LIVER/DOG/PORPHYRIA .......................................................................................................... LIVER/ANXIOLYTIC/LIPID ...................................................................................................... LIVER/CIPROFIBRATE/PROTEIN CHANGES ......................................................................... LTVER/METHYLCLOFENAPATE/PEROXISOME PROLIFERATION..................................... LIVER/COMMERCIAL HEXANE/CHRONIC ........................................................................... LIVER/BIOTRANSFORMATION/ENDOCRINE SYSTEM........................................................ LIVER/PLATELETS/A-NAPTHLISOTHIOCYANATE................................................ ............. LIVER/GLUTATHIONE/ALPHA-NAP HTHYLISOTHIOCYANATE......................................... LIVER/A-NAPATHYLISOTMOCYANATE/LEUKOTRIENES................................................ LIVER/MEMBRANE/CHOLESTEROL....................................................................................... LIVER/PCBS/AROCLOR ............................................................................................................ LIVER/8-HYDROXYDEOXYGUANOSINE/HALOACETATES .............................................. LIVER/CCI4/RETINOL................................................................................................................ LIVER/THYROXINE/FOE 5043 .................................................................................................. LIVER/PESTICIDES/OXIDATIVE DAMAGE ........................................................................... LIVER/TAMOXIFEN/PROLIFERATION ................................................................................... LIVER/DICLOFENAC/PROTEIN ADDUCTS............................................................................. LIVER CELL CULTURE/GSH/ANABOLIC-ANDROGENIC STEROIDS................................. LIVER EFFECTS/OCTAMETHYLCYCLOTETRASILOXANE/INHALATION....................... LIVEREXPLANTS/TRICHLOROETHYLENE/TOXICOKINETICS ........................................ LIVER FUNCTION/TRANSAMINASE/ESTROGEN................................................................. LIVER INJURY/ISOPROPANOL/HEPATOCELLULAR REGENERATION............................. LIVER NECROSIS, PREVENTION/CARBON TETRACHLORIDE/AET AND LIVER INJURY LIVER SLICE/BILE/PEROXISOME PROLIFERATORS............................................................ LIVER SLICES/2-ACETYLAMINOFLUORENE/UNSCHEDULED DNA SYNTHESIS............ LIVER SLICES/TAUROCHOLATE UPTAKE/CYTOCHROME P-450 ..................................... LIVER SLICES/ACETAMINOPHEN/HEPATOTOXICITY........................................................ LIVER SLICES/IN VITRO/STRESS PROTEINS......................................................................... LIVER SLICES/CRESOL/HEPATOTOXICrrY........................................................................... LIVER SLICES/FUMONISIN/AFLATOXIN............................................................................... LIVER SLICES/CYTOCHROME P4501 A/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN ... LIVER TOXICITY/BENZOPHENONE/DOSED FEED................................................................ LIVER TRANSPLANTATION/RADICALS/ALCOHOL ............................................................ LIVER TRANSPLANTATION/ELECTRON MICROSCOPY/SINUSOIDAL CELLS................ LIVER TRANSPLANTATION/FREE RADICALS/METHANOL .............................................. LIVER ULTRASTRUCTURE/PCB CONGENER #77/ENVTRONMENTAL CONTAMINANT . LLC-PKi CELL/FUMONISIN/SPHINGOLIPID ......................................................................... LMPCR/DNA MODIFICATION/PHOTO-CHEMICAL MAPPING............................................ LOCAL ANESTHETICS/CALCIUM/CULTURED HEART CELLS ........................................... LOCAL LYMPH NODE ASSAY/CONTACT ALLERGY/HUMAN MAXIMIZATION TEST .. LOCAL LYMPH NODE ASSAY/FLOW CYTOMETRY/LYMPHOCTE ................................... LOCAL LYMPH NODE ASSAY/CONTACT HYPERSENSITTVITYATTAMIN A DIET.......... LOCAL LYMPH NODE ASSAY/ORAL MUCOSA/CONTACT HYPERSENSITIVITY........... LOCOMOTOR ACTTVITY/VEHICLES/METHODS................................................................... 518 ---- 691 .704 -707 .869 886 928 ... .692 ... .698 ...1086 ....693 ...1448 ...1049 ....... 36 ....... 29 ....... 30 ....... 31 ....... 33 ... .362 ... .773 ...1617 ... .829 ... .628 .. .1089 ...1466 ...1459 ...772 ... .857 ...1475 ...1255 ...1257 ...1261 ...1267 .. .298 \flCOt L.ONG tPNGI^ONGl,ONG[,ONGtPWL tPWF ipw-i LOW-1 LPS(E lung lung. lung lung lung lung lung lung lung lung lunc lung lunc lunc lunc LUNC lunc LUNC LYM1 LYM1 LYM! LYM lym: LYM LYM LYM LYSt M-74 M-Bl MAr MAC MAC MAC MAC MAC MAC MAC MAC MAC MAC MAC MA< MAi MA1 511904 0241 691 LOCOMOTOR ACmVTTY/CHOLINERGIC MODIFIERS/COCAINE........................................................................................... 299 704 LONG CHAIN ACYL COA/CULTURED HEPATOCYTES/MITOCHONDRIA ............................................................................ 326 707 LONG-EVANS RAT/TCDD/T0XICOKINETICS .......................................................................................................................... 1043 869 LONG-TERM INHALATION/MALE REPRODUCTIVE SYSTEM TOXICITY/METHANOL.......................................................207 886 LONG-TERM POTENTIATION/GLUTAMATE RELEASE/ALUMINUM..................................................................................... 506 927 LONG-TERM STUDIES/MTD/MTE/CHEMICAL CARCINOGENESIS......................................................................................... 475 928 LOW LEVEL VOC EXPOSURE/INDOOR AIR/SENSORY IRRITATION..................................................................................... 968 931 ILOWNOEITRISKASSESSMENT/ENDOSULFAN ....................................................................................................................... 801 957 LOW-DOSE COMBINATION/MULTI-ORGAN MODEL/SYNERGISM........................................................................................168 963 LOW-DOSE PHARACOKINETICS/DNA ADDUCT DOSIMETRY/ACCELERATOR MASS SPECTROMETRY ........................ 11 100 LPS (ENDOTOXIN)/HEPATOCYTES/ACUTE PHASE PROTEINS...............................................................................................683 104 LUNG/RETENTION/FIBER ............................................................................................................................................................. 141 107 LUNG/CADMIUM/METALLOTHIONEIN......................................................................................................................................144 162 ; LUNG/TIO2/ORGAN CULTURE .......................................:........................................................................................................... 153 167 ! LUNG/GLUTATHIONE/AIRWAYS................................................................................................................................................. 649 234 ! LUNG/METALLOTHIONEIN/CYTOKINES................................................................................................................................... 749 330 LUNG/RICIN/VACCINATION.........................................................................................................................................................779 437 LUNG/GLUTATHIONE/CYCLOPENTADIENYL MANGANESE TRIC....................................................................................... 1197 438 LUNG/OZONE/NITRIC OJODE ..................................................................................................................................................... 1227 440 LUNG/RADLATION/APOPTOSIS ................................................................................................................................................. 1421 446 LUNG/COMPLEMENT/TRIMELLITIC ANHYDRIDE ................................................................................................................ 1611 458 LUNG CANCER/ARTERIOSCLEROTIC/TOBACCO SMOKE .......................................................................................................718 465 LUNG CLEARANCE/TOXICOKINETICS/NICKEL COMPOUNDS .............................................................................................903 468 LUNG CLEARANCE/NITROGEN DIOXIDE/CIGARETTE SMOKE........................................................................................... 1676 535 ; LUNG FIBROBLASTS/RADON-PROGENY/MICRONUCLEUS ................................................................................................. 1275 544 LUNG INJURY/PULMONARY EDEMA/PHOSGENE.................................................................................................................. 1200 598 LUNG MITOCHONDRIA/CIGARETTE SMOKE/MITOCHONDRIAL RESPIRATION.............................................................. 1682 585 LUNG SLICES/ALKYLPHENOL/PROTEIN SYNTHESIS .............................................................................................................. 27 592 LUNG TOXICITY/GENE EXPRESSION/SMOKE, PASSIVE.......................................................................................................1680 598 ! LYMPH NODE CELL PROLIFERATION/CONTACT HYPERSENSITIVITY/ISOTHIAZOLONES........................................... 1262 386 j LYMPH NODE CELLS/INTERLEUKIN 4/CHEMICAL ALLERGENS .-..................................................................................... 1260 593 ! LYMPH NODE CELLS/SKIN SENSITIZATION/CYTOKINES ...................................................................................................1606 448 | LYMPHOCTE/LOCAL LYMPH NODE ASSAY/FLOW CYTOMETRY ..................................................................................... 1257 349 : LYMPHOCYTE/METALS-PESTICIDES/IMMUNOTOXICOLOGY ............................................................................................ 401 .36 LYMPHOCYTE/GENE EXPRESSION/BENZENE......................................................................................................................... 746 .29 LYMPHOCYTES/COCAINE/PROLACTIN................................................................................................................................... 1399 0 LYMPHOKINES/IMMUNE SUPPRESSION/POLYCHLORINATED BIPHENYLS ........................................................................ 17 1 LYSOSOMES/OXYGEN RADICALS/PHAGOCYTOSIS .............................................................................................................. 631 3 M-741/HEPATIC SLICE/TRANSPORT .......................................... 34 2 M-BROMOPHENYL CYSTEINE/RENAL PROXIMAL TUBULE/CELLULAR TOXICITY.........................................................162 3 MAA/SPECIES/IMMUNOSUPPRESSION..:................................................................................................................................. 403 7 MACHINE LEARNING/DEVELOPMENTAL TOXICOLOGY/RISK ASSESSMENT ................................................................ 1145 329 MACROPHAGE/HL-6O/DIFFERENTIATION/ORGANOPHOSPHATES......................................................................................1254 528 MACROPHAGES/SILICA/MAP KINASE....................................................................................................................................... 240 )89 MACROPHAGES/ARSENIC/INSOLUBLE..................................................................................................................................... 242 166 MACROPHAGES/PHOSPHOLIPIDOSIS/IN VITRO ...................................................................................................................... 330 459 MACROPHAGES/PHOSPHOLIPIDOSIS/CLORPHENTERMINE ................................................................................................. 331 772 , MACROPHAGES/PHOSPHOLIPIDOSIS/IN VITRO ...................................................................................................................... 332 357 : MACROPHAGES/IMMUNE SYSTEM/SPECIES COMPARISON .................................................................................................402 475 MACROPHAGES/PHAGOCYTOSIS/MICROGRAVITY................................................................................................................ 407 >55 MACROPHAGES/PHAGOCYTOSIS/KILLING/ORGANOPHOSPHATES................................................................................... 415 >57 MACROPHAGES/12-O-TETRADECANOYLPHORBOL-13-ACETATE/TRANSFORMING GROWTH FACTOR-a.................. 467 >61 MACROPHAGES/IMMUNOTOXICITY/OZONE............................................................................................................................479 >67 MACROPHAGES/HEPATOTOXICITY/CYTOKINES.................................................................................................................... 748 >98 MACROPHAGES/CYTOTOXICITY/CADMIUM............................................................................................................................ 876 MACROPHAGES/PHAGOCYTOSIS/LEAD......................................................................................................................... MACROPHAGES/EICOSANOID/LEAD......................................................................................................................... ' ' MACROPHAGES/TITANIUM OXIDE PARTICLES/TUMOR NECROSIS FACTOR...................................................... '" " T** MACROPHAGES/METHADONE/IMMUNE..................................................................................................................... 13 MACROPHAGES/GALACTOSAMINE/HEPATOTOXICITY............................................................................................ lu MACULAR DEGENERATION/AGING/GLUTATHIONE...................................................................................................... 64X MALACHITE GREEN/DISPOSITION/CHANNEL CATFISH................................................................................. 1710 MALE RAT NEPHROPATHY/NEPHROPATHY/HYDROCARBON NEPHROPATHY..................................................... -169 MALE REPRODUCTIVE SYSTEM/ANDROGEN PRODUCTION/TCDD.........................................................................' j ' MALE REPRODUCTIVE SYSTEM TOXICITY/METHANOL/LONG-TERM INHALATION.............................................. - 207 MALE/FEMALE/URINE/SODIUM SAACHARIN ............................................................................................................... 4J MALEIC ACID/AMINO ACID TRANSPORT/FANCONI SYNDROME .............................................................................. . 19, MALIGNANT CONVERSION/RETINOIC ACID/SKIN CARCINOGENESIS....................................................................... 67, MAMMARY IMPLANT/CARCINOGENICITY BIOASSAY/SDLICONE.................................................................................. ' 8J5 MAMMARY TUMORS/NEPHROPATHY/LEUKEMIA............................................................................................................. 1175 MANGANESE/SUPEROXIDE DISMUTASE/OXIDATIVE STRESS........................................................................................ 534 MANGANESE/BLOOD-BRAIN BARRIER/TRANSPORT ......................................................................................................... 1108 MANGANESE/L-DOPA/CYTOTOXICITY................................................................................................................................... MANUFACTURED GAS PLANT RESIDUE/STRAIN A MICE/TUMORIGENIC......................................................................... MANUFACTURED GAS PLANTS/RISK ASSESSMENT/CYANIDES ........................................................................................549 MAP KINASE/MACROPHAGES/SILICA......................................................................................................................................240 MAP-2/NCAM/TRIMETHYLTIN................................................................................................................................................... 504 MAP-2/NCAM/METHYLMERCURY .......................................................................................................................................... 1113 MARINE MAMMAL/HYDROCARBON/IN VITRO..................................................................................................................... 1645 MARINE MAMMAL/HYDROCARBON/IN VITRO..................................................................................................................... 1646 MARINE MAMMALS/POLYCHLORINATED BIPHENYLS/PLANAR PCBS...........................................................................1647 MARMOSETS/OSTEOPOROSIS/HISTOMORPHOMETRY......................................................................................................... 831 MASS SPECTROMETRY/GLUTATHIONE S-TRANSFERASE/ELECTROSPRAY IONIZATION .......................................... 1317 MASS SPECTROMETRY/HPLC/ANTIOXIDANT....................................................................................................................... 1566 MAST CELLS/NEUROTROPHINS/NERVE GROWTH FACTOR .............................................................................................. 1361 MATERNAL REPRODUCTIVE/GESTATION/SALICYLATE..................................................................................................... 217 MAXIMIZATION TEST/SENSITIZATION TEST/CONTACT DERMATITIS.............................................................................1266 MCF-7 CELLS/MUTANTS/TCDD ................................................................................................................................................. 734 MDM2 GENE/TCDD/P53 ..............................................................................................................................................................1506 MDMA/NEUROTOXICITY/DOPAMINE .................................................................................................................................... 1351 MECHANISM/TCDD/THYMUS.................................................................................................................................................... 1394 MECHANISM-BASED INACTIVATION/CYTOCHROMEP4502Bl/BIOACnVATION........................................................... 499 MECHANISMS/PROTEIN OXIDATION/DIQUAT ...................................................................................................................... 610 MECHANISMS/CHLORINATED PARAFFINS/CARCINOGENESIS ........................................................................................ 1056 MECHANISMS/TOXICITY ASSESSMENTS/HAZARD EVALUATION ...................................................................................1633 MECHANISMS OF DNA DAMAGE/GENOTOXITY/QUERCETIN..............................................................................................841 MECHANISTIC MODELING/TCDD DOSIMETRY/EGF RECEPTOR ........................................................................................725 MEDAKA/HAZARD ASSESSMENT/IMMUNOTOXICOLOGY ................................................................................................ 1254 MEDAKA/H1STOPATHOLOGY/LIFE-CYCLE-STAGES.............................................................................. 1632 MEDAKA/LEACHATE/LANDFILL.............................................................................................................................................. 1640 MEDIUM-TERM LIVER/MULTI-ORGAN MODEL/CARCINOGENESIS .................................................................................. 961 MEIOSIS/DIETHYLSTILBESTROL/GAMETOGENESIS............................................................................................................. 210 MELPHALAN/DNA ALKYLATION/OXIDATIVE STRESS......................................................................................................... 635 MEMBRANE/CHOLESTEROL/LIVER.........................................................................................................................................1446 MEMBRANE CURRENTS/PCBS/NEURONS............................................................................................................................... 1349 MEMORY/ATAXIA/2,4-DITHIOBIURET...................................................................................................................................... 294 MENADIONE/OXIDATIVE INJURY/PLATELETS.......................................................................................................................616 MENADIONE/CALCIUM/MITOCHONDRIA................................................................................................................................ 617 MENOPAUSE/PREGNANCY/LEAD.............................................................................................................................................1385 MENTHOFURAN/IMMUNOCHEMISTRY/PROTEIN ADDUCTS................................................................................................ 365 520 511904 0243 Ml Mi Ml Ml Ml MI MI MI MI MI MI MI MI MI ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME MERCAPTURIC ACIDS/CYCLOPHOSPHAMIDE/ACROLEIN................................................ MERCURIC CHLORIDE/BEHAVIQR/CNS ...................................................................................................................... 370 '' 993 MERCURY/ALPHA-ACID GLYCOPROTEIN/GENE EXPRESSION................................................................................. 995 MERCURY/DMPS/URINARY PORPHYRINS ........................................................................................................................ ' '. 99g MERCURY/METAL-LIGAND COMPLEXES/CELLULAR TOXICITY........................................................................................1013 MERCURY/ASPARTATE/ASTROCYTES .................................................................................................................................... 1112 MERCURY/NEUROTOXICITY/AUTOANTIBODY .....................................................................................................................1116 MERCURY/KIDNEY/ALA SYNTHETASE MRNA.......................................................................................................................1186 MERCURY/OXIDATIVE STRESS/GLUTATHIONE.....................................................................................................................1631 MERCURY-GLUTATHIONE/RENAL GSH AND HG TRANSPORT/RENAL HG ACCUMULATION....................................... 997 MESANGIAL/BENZO(A)PYRENE/PROLIFERATION...................................................................................................................165 MESOTHELIAL CELL/COLLAGEN/AMOS ITE ASBESTOS....................................................................................................... 1667 MESOTHELIOMA/FIBERS/PARTICLES/SILICON CARBIDE WHISKERS .............................................................................. 1664 METABOLIC ACTIVATION/RAT LIVER SLICES/P-450 ................................................................................................................ 25 METABOLIC INHIBITION/CYTOCHROME P-450/STRESS....................................................................................................... 1173 METABOLIC INTERMEDIATE COMPLEX/ISOZYME-SELECTTVE/1 -AMINOBEZOTRIAZOLE DERIVATIVES.................. 108 METABOLIC SUPPLEMENTATION/MYOTOXIOTY/PRAVASTATIN ..................................................................................... 818 METABOLISM/LIVER/IN VITRO..................................................................................................................................................... 26 METABOLISM/RAT LIVER SLICES/CYTOCHROME P-450 ........................................................................................................ 28 METABOLISM/PHARMACOKINETICS/DISPOSITION.................................................................................................................. 82 METABOLISM/CYTOCHROME P-450/VOC.......................................... 103 METABOLISM/SUCCINIMIDE/NEPHROTOXICITY.................................................................................................................... 180 METABOLISM/DAPOXETINE/KIDNEY........................................................................................................................................192 METABOLISM/COMPARATTVE/TRIAZOLOPYRIMIDINE SULFONAMIDE............................................................................393 METABOLISM/OXIDATIVE DAMAGE/TRANSCRIPTION FACTOR......................................................................................... 442 METABOLISM/ZEBRA FISH/AFLATOXIN B1..............................................................................................................................686 METABOLISM/LTVER/SEVOFLURANE....................................................................................................................................... 691 METABOLISM/HSCAS OR CLAY/AFLATOXIN ..........................................................................................................................777 METABOLISM/CADMIUM/ESTERASES....................................................................................................................................... 872 METABOUSM/TCDD/CYTOCHROME P-450 ..............................................................................................................................1047 METABOLISM/IN VITRO/HALOCARBON..................................................................................................................................1068 METABOLISM/TRICHOLORETHYLENE/DICHLOROACETATE............................................................................................. 1081 METABOLISM/KINETICS/TRICHLOROETHYLENE ....................................................... 1082 METABOLISM/STRAIN COMPARISONS/TRICHLOROETHYLENE .............................. 1083 METABOLISM/PHARMACOKINETIC MODELING/TRICHLOROETHYLENE........................................................................1084 METABOLISM/HUMAN/CARCINOGENICITY .......................................................................................................................... 1139 METABOLISM/BUTADIENE EPOXIDE/1,3-BUTADIENE .........................................................................................................1235 METABOLISM/COCAINE/IMMUNOSUPPRESSION.................................................................................................................. 1244 METABOLISM/STYRENE/STYRENE OXIDE.............................................................................................................................. 1288 METABOLISM/2-METHOXYETHANOL/NUCLEAR MAGNETIC RESONANCE SPECTROSC ............................................. 1289 METABOLISM/BIOALKYLATION/POLYNUCLEAR AROMATIC HYDROCARBONS...........................................................1290 METABOLISM/4-METHYLHEPTANE/URINARYMETABOLITES........................................................................................... 1291 METABOLISM/ALLYLNITRILE/CYANIDE................................................................................................................................ 1296 METABOLISM/METHACRYLONITRILE/BILIARY EXCRETION............................................................................................. 1304 METABOLISM/PHYSIOLOGY/IN VITRO....................................................................................................................................1308 METABOLISM/MUCONALDEHYDE METABOLITES/BENZENE ........................................................................................... 1311 METABOLISM/SPECIES DIFFERENCES/4-VINYLCYCLOHEXENE....................................................................................... 1312 METABOLISM/BAP-COATED PARTICLE/PULMONARY ALVEOLAR MACROPHAGE.......................................................1315 METABOLISM/COCAINE/HEART CELL CULTURES .............................................................................................................. 1473 METABOLISM/PESTICIDES/CARBOFURAN.............................................................................................................................. 1521 METABOLISM/PENTACHLOROANISOLE/EXCRETION........................................................................................................... 1714 METABOLISM/DISPOSITION/BENZYLTRIMETHYLAMMONIUM CHLORIDE.................................................................... 1722 METABOLISM IN PREGNANCY/METHOXYPHENAMINE/PHARMACOGENETIC...............................................................1712 METABOLISM OF BAP-COATED PARTICLE/PULMONARY ALVEOLAR MACROPHAGE/DNA BINDING...................... 1316 METABOLITES/HYDROCHLOROFLUOROCARBONS/BIOTRANSFORMATION.................................................................. 1070 521 511904 0244 metaboutes/gc/ms/butadiene..................................................................................... METABOTROPIC RECEPTORS/INSITOL TRISPHOSPHATE/CYANIDE............................. METAL BINDING MOTIFS/ORGANOPHOSPHORUS HYDROLASE/CATALYSIS ............ METAL INTERACTIONS/RAT LYMPHOCYTE RESPONSE/HEAVY METALS ................. METAL-BINDING PROTEINS/KIDNEY/LEAD....................................................................... METAL-BINDING PROTEINS/BRAIN/LEAD......................................................................... METAL-LIGAND COMPLEXES/CELLULAR TOXICITY/MERCURY................................... METALLOTHIONEIN/LUNG/CADMIUM............................................................................... METALLOTHIONEIN/DIMETHYLNITROSAMINE/INFLAMMATION ............................... METALLOTHIONEIN/URETHANE/DEVELOPMENTALTOXICITY ................................... METALLOTfflONEIN/CYTOKINES/LUNG............................................................................. METALLOTHIONEIN/CADMIUM/SELENIUM....................................................................... METALLOTHIONEIN/MT GENE TRANSCRIPTION/CELLULAR HYPERTROPHY............ METALLOTHIONEIN/CADMIUM/HUMAN PLACENTA...................................................... METALLOTHIONEIN/WILSON'S DISEASE/COPPER............................................................ METALLOTHIONEIN/ZINOLIVER........................................................................................ METALLOTHIONEIN/CADMIUM/GENOTOXICITY.............................................................. METALLOTHIONEIN/HEPATOTOXICITY/CADMIUM........................................................ METALLOTHIONEIN/CADMIUM/CISPLATIN ..................................................................... METALLOTHIONEIN/TRANSGENIC/INDUCTION............................................................... METALLOTHIONEIN/GENE EXPRESSION/BRAIN ............................................................. METALLOTHIONEIN/BRAIN/METALS ................................................................................. METALLOTHIONEIN/CADMIUM INHIBITOR/CALCIUM.................................................... METALLOTHIONEIN/PROTO-ONCOGENE/CADMIUM ...................................................... METALLOTHIONEIN/METALS/AQUATIC............................................................................. METALLOTHIONEIN/METALS/AQUATIC............................................................................. METALLOTHIONEIN MRNA/URETHANE/YOLK SAC ........................................................ METALS/METHYLMERCURY/RISK ASSESSMENT............................................................. METALS/TRANSFORMATION/RISK ASSESSMENT ............................................................ METALS/RISK ASSESSMENT/ROUTE-TO-ROUTE EXTRAPOLATION............................. METALS/KIDNEY/CHELATORS ............................................................................................ METALS/PLACENTA/PROSTACYCLIN................................................................................. METALS/RISK ASSESSMENT/EXPOSURE ASSESSMENT.................................................. METALS/INHmmON/NITRIC OXIDE SYNTHASE .............................................................. METALS/METALLOTHIONEIN/BRAIN ................................................................................. METALS/OXTOATTVE INJURY/CARCINOGENESIS.............................................................. METALS/FISH/IMMUNOTOXICOLOGY................................................................................. METALS/MICROGLIA/CENTRAL NERVOUS SYSTEM ........................................................ METALS/HORMESIS/REGENERATION................................................................................. METALS/AQUATIC/METALLOTHIONEIN............................................................................. METALS/AQUATIC/METALLOTHIONEIN............................................................................. METALS-PESTICIDES/IMMUNOTOXICOLOGY/LYMPHOCYTE...................................... METALWORKING FLUID/SENSORY IRRITATION/PULMONARY IRRITATION............. METAM SODIUM/OVULATION/CATECHOLAMINES.......................................................... METHACRYLATES/SENSORY IRRITATION......................................................................... METHACRYLONITRILE/BILIARYEXCRETION/METABOLISM........................................ METHADONE/IMMUNE/MACROPHAGES............................................................................. METHAMIDOPHOS/OPIDP/HUMAN....................... ............................................................ METHAMPHETAMINE/PHENCYCLIDINE/TEMPORAL RESPONSE DIFFERENTIATION METHAMPHETAMINE/6-HYDROXYDOPAMINE/ASTROCYTES...................................... METHAMPHETAMINE/CARBON TETRACHLORODE/CELL REPLICATION................... METHAMPHETAMINE/PARKINSONISM/MPTP................................................................... METHANOL/PHARMACOKINETICS/MONKEYS OO OO OO OO OO OO OO 39 1413 1363 .1111 ..1188 ..1189 ..1652 . .1653 .. .569 ....60 ... .63 ....64 ...218 .. .553 .. .737 ..mi ..1191 ,1254a ..1338 . .1436 . .1652 . .1653 .. .401 . .1203 ...214 ..1210 ..1304 ..1398 ..1534 ...305 ..1345 ..1469 ..1576 ..1333 .. .207 .. .392 ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME ME Ml Ml Ml Ml Ml Ml MI MI MI MI MI MI MI MI MI MI MI MI Ml 511904 0245 METHANOL/FOLATE/RETINA....................................................................................................................................................... 979 METHANOL/FOLATE/MICE '... ...................................................................................................................................................1451 METHANOL/LIVER TRANSPLANTATION/FREE RADICALS ................................................................................................. 1466 METHANOL/KUPFFER CELLS/CARBON TETRACHLORIDE ................................................................................................. 1470 ; METHEMOGLOBIN/NTTRITE/CYANIDE .................................................................................................................................... 825 1 METHEMOGLOBIN/HEINZ BODY/ANEMIA............................................................................................................................. 1548 METHEMOGLOBIN/ANALYSIS/AUTOMATED ........................................................................................................................ 1572 METHEMOGLOBINEMIA/LIPID PEROXIDATION AND EXERCISE/OXIDATTVE INJURY .................................................. 627 METHEMOGLOBINEMIA/MIXTURE/N.N-DIMETHYLANILINE............................................................................................... 824 METHIONINE/S-ADENOSYLMETHIONINE/BROMOTHIOCATECHOL/METHYLATION...................................................... 372 METHOD VALIDATION/INTRANASAL DOSING/DOSE DISTRIBUTION PATTERN...............................................................156 METHOD VALIDATION/POSITIVE CONTROL STUDY/DEVELOPMENTAL NEUROTOXICITY ....................................... 1377 : METHODOLOGY/INTRAVENOUS/INFUSION .......................................................................................................................... 863 1 METHODS/LOCOMOTOR ACnVITY/VEHICLES.......................................................................................................................298 METHODS/CONGENER SPECIHC/PCBS ....................................................................................................................................1063 METHODS/TISSUE CREATINE/b-GUANIDINOPROPIONIC ACID........................................................................................... 1570 METHOMYL/ATROPINE/MEMANTINE/OXAMYL.................................................................................................................... 1545 I METHOXYPHENAMINE/PHARMACOGENETIC/METABOLISM IN PREGNANCY............................................................. 1712 i METHYL DITHIOCARBAMATE/ISOTHIOCYANATE/PROTEIN ADDUCT ...........................................................................1697 i METHYL MERCURY/FREE RADICAL/OXIDANT INJURY/BCL-2............................................................................................ 609 I METHYL PARATHION/BIOMARKERS/CARBOFURAN ........................................................................................................... 916 j METHYL TERT-BUTYL ETHER (MTBEyPERCUTANEOUS ABSORPTION/GASOLINE OXYGENATE.............................. 336 i METHYL TERTIARY BUTYL ETHER/RISK ASSESSMENT/CARCINOGENICITY .................................................................540 ! METHYLATION/METHIONINE/S-ADENOSYLMETHIONINE/BROMOTHIOCATECHOL..................................................... 372 ! METHYLATION/CATECHOL ESTROGENS/GLUTATHIONE CONJUGATION .......................................................................657 METHYLCLOFENAPATE/PEROXISOME PROLIFERATION/LIVER........................................................................................1167 ! METHYLENE CHLORIDE/DNA DAMAGE/MOUSE LIVER......................................................................................................1074 I METHYLENE DIANILINE/HEPATOTOXICITY/TAURINE ......................................................................................................1443 : METHYLENE DIANILINE/BILE DUCT INJURY/BILIARY EXCRETION.................................................................................1445 ! METHYLENEDIPHENYL DHSOCYANTE (MDI)/BIOMARKERS/PROTEIN ADDUCTS........................................................1411 METHYLENEDIPHENYL DIISOCYNATE (MDIJ/DISTRIBUTION/BIOMARKERS ................................................................ 1410 METHYLETHYLKETOXIME/INHALATION/ONCOGENICITY................................................................................................. 1220 METHYLMERCURY/RISK ASSESSMENT/METALS......................................................................................................................60 METHYLMERCURY/DEVELOPMENTAL TOXICITY/DOSE-RESPONSE MODEL .................................................................... 61 METHYLMERCURY/NEURONAL EXCITABIUTY/HIPPOCAMPAL SLICE............................................................................. 500 METHYLMERCURY/MONKEYS/VISION..................................................................................................................................... 989 METHYLMERCURY/ASTROCYTES/MORPHOMETRICS.......................................................................................................... 990 METHYLMERCURY/DEVELOPMENTAL EXPOSURE/SOMATOSENSORY FUNCTION........................................................ 991 METHYLMERCURY/MICE/BEHAVIOR....................................................................................................................................... 992 METHYLMERCURY/ASPARTATE/ASTROCYTES.................................................................................................................... 1110 METHYLMERCURY/MAP-2/NCAM ........................................................................................................................................... 1113 METHYLMERCURY/BRAIN/NCAM........................................................................................................................................... 1114 METHYLMERCURY/ZINC/NERVE TERMINAL ........................................................................................................................ 1115 METHYLMERCURY/BLOOD-BRAIN BARRIER/AMINO ACID TRANSPORT SYSTEM L..................................................... 1184 METHYLMERCURY/GLUTATHIONE/BLOOD-BRAIN BARRIER........................................................................................... 1185 METHYLMERCURY/CALCIUM/CENTRAL NERVOUS SYSTEM ........................................................................................... 1187 METHYLMERCURY/T AND B LINEAGE CELLS/AUTOIMMUNITY........................................................................................1251 METHYLMERCURY/INTRACELLULARCALCIUM/NEUROTOXICITY.................................................................................. 1494 MEXICO/LEAD TOXICITY/LEAD-GLAZED CERAMICS............................................................................................................ 895 MICE/PAHS/IMMUNOTOXICOLOGY..............................................................................................................................................16 MICE/CYTOCHROME P4502B1 /PHENOBARBITAL.....................................................................................................................117 MICE/CYTOCHROME P-450/INDUCTION ....................................................................................................................................126 MICE/G-GLUTAMYLCYSTEINE SYNTHETASE/MOLECULAR CLONING............................................................................. 641 MICE/ACUTE/PETROLEUM.......................................................................................................................................................... 687 MICE/BEHAVIOR/METHYLMERCURY....................................................................................................................................... 992 523 511904 0246 MICE/METHANOL/FQLATE................................................................................................................................................ MICE/MUCONALDEHYDE/DISTRIBUTION ........................................................................................................................ Ml ${ Ml MICROANALYSIS/GADOLINIUM/ULTRASTRUCTURE................................................................................................ ,, Ml MICROCAPNOMETRY/CARBON DIOXIDE/BLOOD GASES .............................................................................................. Ml MICROCYSTIN/CYTOSKELETON/CYANOBACTERIA...................................................................................................... 7 Ml MICROCYSTIN/CALYCULIN A/PROTEIN PHOSPHATASE .......................................................................................... ' ' 1094 Ml MICRODIALYSIS/HYDROXYL RADICALS/GCMS ........................................................................................................... '' ^ Ml MICROGLIA/CENTRAL NERVOUS SYSTEM/METALS......................................................................................................' ' ,338 Ml MICROGRANULOMATA/HISTTOCYTOSIS/WHITE OIL.................................................................................................... ' " 6gg Ml MICROGRAVITY/MACROPHAGES/PHAGOCYTOSIS........................................................................................................ ' 407 Ml MICRONUCLEUS/BENZO(A)PYRENE/CYTOCHROME P-450 ................................................................................................ g37 Mi MICRONUCLEUS/IN VIVO/GENOTOXICITY .......................................................................................................................... 1272 M< MICRONUCLEUS/LUNG FIBROBLASTS/RADON-PROGENY............................................................................................... ,275 Ml MICRONUCLEUS/IN VIVO/OLEFINS........................................................................................................................................ . MICROSATELLITES/SUPPRESSOR GENES/URETHANE (ETHYL CARBAMATE)................................................................. 522 MICROSOMALEPOXIDEHYDROLASE/HUMAN/FETAL ........................................................................................................587 MICROSOMES/REDUCTION/CYTOCHROME P-450 .................................................................................................................. . M< Ml M< M< MICROSOMES/CYTOCHROME P-450/HUMAN............................................................................................................................ 9g MICROSWINE/BIOAVAILABILITY/LEAD.................................................................................................................................. 560 MICROSWINE/BIOAVAILABILITY/LEAD............................................................................... MICROTUBULE/OOCYTE/GLUTATHIONE.................................................................................................................................660 MICROTUBULES/GLUTATHIONE/UTP POOLS ......................................................................................................................... 879 MICROTUBULES/CYTOSKELETON/ACRYLAMIDE/PHOSPHORYLATION........................................................................... 767 MILITARY SITES/SOIL CONTAMINANTS/ORGANOPHOSPHATES....................................................................................... 1635 MINE-ORES/BIOACCUMULATION/LEAD...................................................................................................................................561 MINK/GREAT LAKES FISH/PCBS ...............................................................................................................................................1643 MINK/GREAT LAKES FISH/PCBS ...............................................................................................................................................1644 MINOXTOIL/SULFOTRANSFERASE/SULFATION .................................................................................................................... 1320 MrrOCHONDRIA/RHODAMINE 123/LASER CYTOMETRY......................................................................................................319 MITOCHONDRIA/LONG CHAIN ACYL COA/CULTURED HEPATOCYTES ........................................................................... 326 MITOCHONDRIA/MUTAGENESIS/AIDS .....................................................................................................................................531 MITOCHONDRIA/DOXORUBICIN/CALCIUM............................................................................................................................. 596 MITOCHONDRIA/OXIDATTVE DAMAGE/HYDROXYL FREE RADICALS .............................................................................603 MITOCHONDRIA/QUINONES/CALCIUM.....................................................................................................................................614 MITOCHONDRIA/MENADIONE/CALCIUM................................................................................................................................. 617 MITOCHONDRIA/CALCIUM/T-BUTYLHYDROPEROXIDE...................................................................................................... 619 MITOCHONDRIA/VTTAMIN E/OXIDAITVE INJURY..................................................................................................................622 MITOCHONDRIA/CYANIDE/ENVIRONMENTAL CONTAMINANT.........................................................................................637 MITOCHONDRIA/B-OXIDATION/LIVER..................................................................................................................................... 707 MITOCHONDRIA/ADDUCTS/STRESS PROTEINS .................................................................................................................... 1136 MITOCHONDRIA/DICHLOROVINYL CSTEINE/CALCIUM ..................................................................................................... 1490 MITOCHONDRIA/CALCIUM/ANOXIA....................................................................................................................................... 1495 MITOCHONDRIA/BENZO(A)PYRENE/STROMALCELLS .......................................................................................................1551 MITOCHONDRIA/HUNTINGTON'S DISEASE/EXCITOTOXICITY ..........................................................................................1574 MITOCHONDRIAL MEMBRANE POTENTIAL/GAP JUNCTIONS/VITAL FLUORESCENCE ................................................. 139 MITOCHONDRIAL PERMEABILITY TRANSITIO/CELL DEATH/LIVER ................................................................................. 928 MITOCHONDRIAL RESPIRATION/LUNG MITOCHONDRIA/CIGARETTE SMOKE...............................................................1682 MITOCHONDRIAL TOXICITY/GLUTATHIONE S-TRANSFERASE/PENTACHLOROPHENOL ......................... 1455 MITROGENESIS/CARCINOGENESIS/TEMPERATURE........................................................................................... 433 MIXING/OPTIMUM OPERATING CONDITIONS/NOSE-ONLY UNIT ........................................................................................159 MIXTURE/N.N-DIMETHYLANILINE/METHEMOGLOBINEMIA............................................................................................... 824 MIXTURES/SOLVENTS/TOXICOKINETICS................................................................................................................................... 69 MIXTURES/HALOGENATED HYDROCARBONS/TOXICOKINETICS ....................................................................................... 70 MIXTURES/GASES/VAPORS/TOXICOKINETICS.......................................................................................................................... 71 MIXTURES/SOLVENTS/TOXICOKINETICS....................................................................................................................................72 M< Ml Ml Ml M< Ml Ml Ml Ml Ml Ml Ml Ml Ml Ml Ml Ml Ml Mi M' M M M M M M' Ml Ml Ml Ml Ml Ml Ml M' M' M' Ml Ml 511904 0247 MIXTURES/ENVIRONMENTAL/TOXICOKINETICS .................................................................................................................... .. MIXTURES/STYRENE/1.3-BUTADIENE ........................................................................................................................................87 MIXTURES/TOXICOKINETICS/BIOTRANFORMATION, PHASE I ........................................................................................... 397 MIXTURES/CARCINOGENESIS/BIOMARKERS.......................................................................................................................... 471 MIXTURES/IRRITATION/CARPETS ............................................................................................................................................973a MIXTURES/INTERACTION/COMBINATION TOXICOLOGY................................................................................................... 1153 MIXTURES/NASAL TOXICITY/ALDEHYDES.............................................................................................................................1195 VIIXTURES/CHLOROFORM/TRICHLOROETHYLENE............................................................................................................... 1471 MK80I/INOSITOL POLYPHOSPHATES/PHENCYCLIDINE ............................................................................................ 804 MNRGP120/VACCINE/DEVELOPMENTAL TOXICITY .............................................................................................................. 527 MODEL/DOSE-RESPONSE/STOCHASTIC .................................................................................................................................. 1143 MODEL SIMULATION/PCDD/PCDF/TOXICOKINETICS........................................................................................................... 1045 MODELING/RISK ASSESSMENT/DOSIMETRY .........................................................................................................................1142 MODELING/VINYL ACETATE/NASAL METABOLISM............................................................................................................. 1209 MODELING/PHARMACOKINETICS/PBPK................................................................................................................. 1715 MODELING ERROR/EXPOSURE-RESPONSE/TETRACHLOROETHYLENE .......................................................................... 1585 MODELS/PROTEINS/ALLERGY....................................................................................................................................................1256 MOLECULAR/ESTROGEN RECEPTORS/TCDD OR DIOXIN .....................................................................................................729 MOLECULAR BIOMARKERS/ENVIRONMENTAL MONTTORING/STRESS PROTEINS ....................................................... 1133 MOLECULAR CLONING/MICE/G-GLUTAMYLCYSTEINE SYNTHETASE..............................................................................641 MOLECULAR ENDPOINT/GENE INDUCTION/STRESS GENES.................................................................................................452 MOLECULAR MODELING/INDOLE COMPOUNDS/CHEMOPROTECTION............................................................................... 44 MOLECULAR PROBE/LASER CONFOCAL MICROSCOPE/CYTOCHROME P-450 INDUCTION........................................... 315 MOLYBDENUM/GLYCOSAMINOGLYCAN/SULFATION......................................................................................................... 1329 MONKEY OVARY/HEXACHLOROBENZENE/ULTRASTRUCTURE......................................................................................... 211 MONKEYS/METHANOL/PHARMACOKINETICS........................................................................................................................ 392 MONKEYS/BRIMONIDINE/EYE..................................................................................................................................................... 975 MONKEYS/OFLOXACIN/EYE .......................................................................................................................................................977 MONKEYS/VISION/METHYLMERCURY..................................................................................................................................... 989 MONKEYS/RADIOTELEMETRY/CARDIOVASCULAR.............................................................................................................1480 MONOAMINES/TURNOVER RATE/THALLIUM........................................................................................................................ 1022 MONOCHLOROACETIC ACID/ASTROCYTES/GLUTATHIONE ............................................................................................. 1057 MONTE CARLO SIMULATION/CHEMICAL/RADIATION DOSE/UNCERTAINTY ANALYSIS ........................................... 1149 MORPHOLOGIC RESPONSE/BILIARY TREE/CHEMICAL INJURY........................................................................................... 714 MORPHOLOGY/ACRYLAMIDE/GROWTH CONE ......................................................................................................................769 MORPHOMETRICS/METHYLMERCURY/ASTROCYTES.......................................................................................................... 990 MORPHOMETRY/OZONE/SULFURIC ACID .............................................................................................................................. 1230 MOTOR ACTIVITY/PESTICIDES/INTERACTIONS...................................................................................................................... 292 MOTOR ACTIVITY/PESTICIDES/OPERANT BEHAVIOR ...........................................................................................................293 MOTOR ACTTVITY/NEUROTOXICITY/REGULATORY ............................................................................................................ 295 MOTOR ACTIVITY/CORRELATION/CHOLINESTERASE INHIBITION .................................. 912 MOTOR ACTIVITY/NEUROTOXINS/FOB ..................................................................................................................................1378 MOTOR ACTTVITY/FUNCTIONAL OBSERVATIONAL BATTERY/NEUROPATHOLOGY ................................................... 1379 MOTOR ACTIVITY/SOLVENTS/RISK ASSESSMENT ...............................................................................................................1431 MOUSE/SALINE/INFUSION ...........................................................................................................................................................865 MOUSE/1,1 -DICHLOROETHYLENE/CYTOCHROME P-450 2E1............................................................................................... 1457 MOUSE HEPATOCYTES/THIOLS/OXIDATIVE STRESS ............................................................................................................ 606 MOUSE LIVER/DNA METHYLATION/HA-RAS ..........................................................................................................................514 MOUSE LIVER/METHYLENE CHLORIDE/DNA DAMAGE....................................................................................................... 1074 MPTP/METHAMPHETAMINE/PARKINSONISM........................................................................................................................ 1576 MT GENE TRANSCRIPTION/CELLULAR HYPERTROPHY/METALLOTHIONEIN.................................................................. 883 MTD/MTE/CHEMICAL CARCINOGENESIS/LONG-TERM STUDIES......................................................................................... 475 MTDNA/GENOTOXICITY/DIETHYLSTILBESTROL .................................................................................................................1271 MUCONALDEHYDE/DISTRIBUTION/MICE .............................................................................................................................. t723 MUCONALDEHYDE METABOLITES/MUTAGENICITY/V79 CELLS ....................................................................................... 852 525 511904 0248 1 A MULTI-ORGAN MODEL/SYNERGISM/LOW-DOSE COMBINATION MULTI-ORGAN MODEL/CARCINOGENESIS/MEDIUM-TERM LIVER 168 MULTICASE/SENSmZATION/STRUCTURE-ACTIVITY ........................................................ 961 MULTIDRUG RESISTANCE (MDRVPESTICIDES/INSECTICIDES/RESISTANCE................. '264 MULTISTAGE CARCINOGENESIS/HALOGENATED PESTICIDEmJMOR PROMOTERS .. 1543 MUNITION CHEMICAL/TETRYL/DRUG METABOLIZING ENZYMES ................................. 463 MUNrnONCHEMICAL/PATHOLOGY/2,4,6-TRINrrROPHENYLMETHYLNTTRAMINE ... 706 MUNITION CHEMICALS/TRINITROBENZENE/DRUG METABOLIZING ENZYMES .......... MURINE MODEL/TOLUENE DnSOCYANATE/SENSITIZATION .......................................... MUSCARINIC RECEPTOR/HIPPOCAMPUS/LEAD................................................................... MUSCARINIC RECEPTORS/FUNCTIONAL ENDPOINTS/ORGANOPHOSPHATES ............. MUSCARINICRECEPTORS/ACETYLCHOLINESTERASE/ORGANOPHOSPHATES ............ MUSCARINIC RECEPTORS/NEUROBLASTOMA CELLS/ORGANOPHOSPHORUS ESTERS MUTAGENESIS/AIDS/MITOCHONDRIA................................................................................... MUTAGENIC ASSESSMENT/RISK ASSESSMENT/DRUG DEVELOPMENT......................... MUTAGENICITY/HYDRALAZINE/N-ACETYLTRANSFERASE.............................................. MUTAGENICITY/VITAMIN B15/IN VIVO/IN VITRO................................................................ MUTAGENICITY/PHENYLENEDIAMINE/STRUCTURE-ACnvrrY....................................... MUTAGENICITY/V79 CELLS/MUCONALDEHYDE METABOLITES ..................................... MUTAGENICITY/REPELLENT/ACUTE ..................................................................................... MUTAGENICITY/TRANSGENIC ANIMALS/VALIDATION .................................................... MUTAGENICITY/BENZO(A)PYRENE/TRANSGENIC MICE.................................................... MUTAGENICITY/MUTAMOUSE/HEXAVALENTCHROMIUM.............................................. MUTAGENICITY/GENOTOXICITY/AMES ASSAY................................................................... MUTAGENTICITY/GENOTOXICITY/VALIDATION STUDY .................................................. MUTAMOUSE/HEXAVALENT CHROMIUM/MUTAGENICITY.............................................. 1560 709 1607 502 907 .919 920 531 558 ...84J -.846 ...847 .852 ...923 ...939 ...941 .. .943 ..1273 .. .851 .. .943 MUTANTS/TCDD/MCF-7CELLS .................................................................................................................................................734 MUTATION/INFLAMMATION/SILICA.......................................................................................................................................278 MUTATION/DNA REPAIR/GENOTOXICITY.............................................................................................................................850 MUTATION/1,3-BUTADIENE/TRANSGENIC ...........................................................................................................................942 MUTATION/BIOASSAY/GENOTOXICITY.............................................................................................................................. 1285b MUTATIONS/H-RAS GENE/PANCREAS.....................................................................................................................................513 MUTATOX/SEDIMENT/AMES ASSAY..................................................................................................................................... 1634 MYCOBACTERIA/PHYLOGENY/BIODEGRADATION...........................................................................................................1630 MYCOBACTERIUMAVIUM/PHARMACOKINETICSArOXICOKINETTCS/ETHAMBUTOL.................................................. 533 MYCOTOXm/CYTOTOXICrrY/ONCOGENES ............ 516 MYCOTOXIN/T CELL/IMMUNOTOXICOLOGY.............. 756 MYCOTOXIN/GENE EXPRESSION/INTERLEUKIN..................................................................................................................757 MYCOTOXIN/PROGRAMMED CELL DEATH/FLOW CYTOMETRY ....................................................................................1423 MYELOTOXICITY/HEPATOTOXICITY/ANTICANCERAGENTS ......................................................................................... 1105 MYOTOXICITY/PRAVASTATIN/METABOLIC SUPPLEMENTATION................................................................................... 818 N.N-DIMETHYLANILINE/METHEMOGLOBINEMIA/MIXTURE.............................................................................................824 N-ACETYLATION/GENOTOXICITY/BATRACYLIN ................................................................................................................ 836 N-ACETYLTRANSFERASE/MUTAGENICTTY/HYDRALAZINE...............................................................................................845 N-BUTYL-1 -DEOXYNOJIRMYCIN/AIDS/THYROID ................................................................................................................ 530 N-NTTROSO COMPOUNDS/DIFFERENTIATION/DEVELOPMENTAL TOXICITY ................................................................ 591 N-METHYL-L-ARGININE/ANTIHYPOTENSIVE DRUG/NO SYNTHASE INHIBITOR ........................................................ 803 NANOPARTICLE/X-RAY CONTRAST/IODINATED.................................................................................................................. 833 NAPHTHALENE/COVALENT BINDING.................................................................................................................................... 1701 NASAL/CARBOXYLESTERASE//N VITRO KINETICS ............................................................................................................... 151 NASAL CARCINOGENESIS/RISK ASSESSMENT/CELL PROLIFERATION............................................................................ 536 NASAL CAVITY/VAPOR UPTAKE/ACETALDEHYDE............................................................................................................. 1194 NASAL IRRITATION/CHLORINE/INHALATION ..................................................................................................................... 1221 NASAL METABOLISM/MODELING/VINYL ACETATE............................................................................................................1209 526 511904 0249 NASAL TOXICITY/UPPER RESPIRATORY TRACT/RISK ASSESSMENT .................................................................... ........155 NASAL TOXICITY/ALDEHYDES/MIXTURES.............................................................................................................................U95 NASAL TOXICITY/GLUTATHIONE DEPLETION/ETHYL ACRYLATE .................................................................. 1211 NASAL TOXICITY/OLFACTORY TOXICITY/ACRYLIC ACID..................................................................................................1212 NASAL TOXICITY/HEXAMETHYPHOSPHORAMIDE/CELL PROLIFERATION.....................................................................1218 NASAL TOXICITY/SHEEP/NITROGEN DIOXIDE.......................................................................................................................1225 NATURAL KILLER ACTTVTTY/INFLUENZA VIRUS/TCDD ..................................................................................................... 1515 NATURAL KILLER CELLS/IMMUNOTOXICOLOGY/SIUCONE..............................................................................................1250 NATURAL PRODUCTS/HUMAN EXPOSURE/HYDROQUINONE ............................................................................................. 788 NCAM/TRIMETHYLTIN/MAP-2..................................................................................................................................................... 504 NCAM/METHYLMERCURY/MAP-2 ............................................................................................................................................1113 NCAM/METHYLMERCURY/BRAIN ............................................................................................................................................1114 NCI/NTP BIOASSAYS/QSAR/CARCINOGENICITY .................................................................................................................... 474 NECROSIS/BILE ACID SEQUESTERANT/CHOLESTYRAMINE............................................................................................... 1090 NEGATIVE REGULATORY ELELMENT/PHOSPHOROTHIOATE OLIGONUCLEOTIDE/RAT CYP1A1 ................................ 125 NEOMYCIN/NEPHROTOXICrTY/IN VITRO................................................................................................................................. 317 NEOMYCIN/DMSA/LEAD............................................................................................................................................................. 1002 NEONATAL/CHEMOPREVENTION/DIETHYLSTILBESTROL.....................................................................................................45 NEONATES/SEVOFLURANE/BIOTRANSFORMATION.............................................................................................................1718 NEOPLASIA/TGF-a/UTERUS ........................................................................................................................................................ 466 NEPHROPATHY/HYDROCARBON NEPHROPATHY/MALE RAT NEPHROPATHY................................................................ 169 NEPHROPATHY/LEUKEMIA/MAMMARY TUMORS................................... 1175 NEPHROTOXICITY/HEPATOTOXICITY/BIOACTTVATION....................................................................................................... 170 NEPHROTOXICITY/HEPATOTOXICITY/HALOANILINES......................................................................................................... 172 NEPHROTOXICITY/URINARY MARKERS/LDH ISOENZYMES ............................................................................................... 173 NEPHROTOXICITY/KALLIKREIN/VANCOMYCIN.....................................................................................................................174 NEPHROTOXICITY/SUCCINIMIDE/RENAL FUNCTION.............................................................................................................177 NEPHROTOXICITY/METABOLISM/SUCCINIMIDE.................................................................................................................... 180 NEPHROTOXICITY/GLUTATHIONE/p-AMINOPHENOL ...........................................................................................................181 NEPHROTOXICITY/DIABETES/CEPHALORIDINE .................................................................................................................... 185 NEPHROTOXICITY/IMMUNOSUPPRESSANTS/CYTOTOXICITY............................................................................................. 187 NEPHROTOXICITY/QUINONES/RENALTRANSPORT.............................................................................................................. 193 NEPHROTOXICITY/IN VIVO COVALENT BINDING/ACETAMINOPHEN................................................................................195 NEPHROTOXICITY/IN VITRO/NEOMYCIN................................................................................................................................. 317 NEPHROTOXICITY/IN VITRO/PENTAMIDINE........................................................................................................................... 532 NEPHROTOXICITY/TERT-BUTYL-HYDROXYANISOLE/GLUTATHIONE............................................................................. 651 NEPHROTOXICITY/QUINONE-THIOETHERS/COVALENTBINDING ..................................................................................... 652 NEPHROTOXICITY/BROMODICHLOROMETHANE/CHLOROFORM..................................................................................... 1075 NEPHROTOXICITY/BROMODICHLOROMETHANE/BROMOFORM ..................................................................................... 1076 NEPHROTOXICITY/CYCLOSPORIN/TOTAL PARENTERAL NUTRITION..............................................................................1181 NEPHROTOXICITY/CYP2E1/ACETAMINOPHEN...................................................................................................................... 1689 NEPHROTOXICITY/DEHYDROGENASES/TARGETS .............................................................................................................. 1695 NEROTOXICITY/AH RECEPTOR/CYP1A1..................................................................................................................................1341 NERVE/ANESTHESIA/BISULFITE............................................................................................................................................... 1348 NERVE GROWTH FACTOR/MAST CELLS/NEUROTROPHINS ............................................................................................... 1361 NERVE GROWTH FACTOR/NEUROTROPHINS/NEUROPEPTIDES ....................................................................................... 1362 NERVE TERMINAL/METHYLMERCURY/ZINC ........................................................................................................................ 1115 NEURITES/SCHWANN CELLS/REGENERATION............................................................................................................................2 NEUROBEHAVIORAL/NEUROTOXICITY/NEUROPATHOLOGY............................................................................................. 821 NEUROBEHAVIORAL/IBOGAINE HC1/PRECLINICAL TOXICITY STUDY ............................................................................827 NEUROBEHAVIORAL/IBOGAINE HC1/PRECLINICAL TOXICITY STUDY ............................................................................828 NEUROBEHAVIORAL/NEUROPSYCHOLOGICALTESTS/PCBS............................................................................................. 1062 NEUROBEHAVIORAL/TOXICOKINETICS/1,1.1 -TRICHLOROETHANE.................................................................................. 1370 NEUROBLASTOMA CELLS/ORGANOPHOSPHORUS ESTERS/MUSCARINIC RECEPTORS.................................................920 NEUROCHEMISTRY/ORGANOPHOSPHATES/PREGNANCY................................................................................................... 1530 527 511904 0250 I NEUROCHEMISTRY/ORGANOPHOSPHORUS/DEVELOPMENTAL....................................................................................... 542 NEURODEGENERATION/CYANIDE/EXC1TOTOX1CITY...................................................................................................... 1577 NEURODEGENERATTVEDISEASES/NEUROTOXIClTY/EXCrrOTOXINS ......................................................................... 1573 NEUROENDOCRINE/IMMUNOENHANCEMENT/COCAINE ...................................................................................................1242 NEUROFILAMENT/1.2-DIETHYL BENZENE/CROSSUNKING ................................................................................................76, NEUROFILAMENT/CARBONDISULFTDE/CYTOSKELETON................................................................................................ ?64 NEUROFILAMENT/CARBON DISULFIDE/CROSSLINKING.................................................................................................. 76J NEUROGLIAL CELLS/NEUROREGENERATION/SCHWANN CELLS.................................................................................. 4 NEURONAL EXCITABILITY/HIPPOCAMPAL SLICE/METHYLMERCURY....................................................................... ' '500 NEURONAL INJURY/REGENERATION/NEUROTOXICITY ................................................................................................. ' | NEURONS/CALCIUM/LEAD...................................................................................................................................................... ' 249 NEURONS/TCDD/CALCIUM..................................................................................................................................................... ' 50g NEURONS/MEMBRANE CURRENTS/PCBS.............................................................................................................................. . NEUROPATHOLOGY/NOVEL FLUORESCENT METHOD/DOMOIC ACID ......................................................................... 5,0 NEUROPATHOLOGY/NEUROBEHAVIORAL/NEUROTOXICITY......................................................................................... ... NEUROPATHOLOGY/MOTOR ACTIVITY/FUNCTIONAL OBSERVATIONAL BATTERY ............................................ ;.. 1379 NEUROPATHY/AXONAL TRANSPORT/TAXOL......................................................................................................................... NEUROPATHY/BROMOPHENYLACETYLUREA/FUNCTIONAL OBSERVATIONAL BATTERY ..................................... .. NEUROPATHY/UBIQUITIN/BROMOPHENYLACTYLUREA................................................................................................. . NEUROPATHY TARGET ESTERASE/SH-SY5Y HUMAN NEUROBLASTOMA CELLS/ACETYLCHOLINESTERASE.......313 NEUROPEPTIDES/NERVE GROWTH FACTOR/NEUROTROPHINS ..................................................................................... .. NEUROPHILS/CYTOKINES/CHEMOTACTIC FACTORS.......................................................................................................... . NEUROPSYCHOLOGICAL TESTS/PCBS/NEUROBEHAVIORAL............................................................................................ 1062 NEUROREGENERATION/SCHWANN CELLS/NEUROGLIAL CELLS.........................................................................................4 NEUROTOXIC ESTERASE/ISOMALATHION/ACETYLCHOLINESTERASE ..........................................................................911 NEUROTOXIC ESTERASE/OPIDN/RATS.................................................................................................................................. 1356 NEUROTOXICITY/NEURONAL INJURY/REGENERATION ........................................................................................................ I NEUROTOXICITY/REGULATORY/MOTOR ACTIVITY .......................................................................................................... 295 NEUROTOXICITY/TRIMETHYLTIN/LEARNING......................................................................................................................303 NEUROTOXICITY/INHALATION/ISOPROPANOL.................................................................................................................... 304 NEUROTOXICITY/DOMOIC ACID/TOXICOKINETICS............................................................................................................ 386 NEUROTOXICITY/TRINITROBENZENE/REPRODUCTION.................................................................................................... 574 NEUROTOXICITY/SOLVENTS/DEVELOPMENTALTOXICITY.............................................................................................. 583 NEUROTOXICITY/1,1.1 -TRICHLOROETHANE/DEVELOPMENTAL.......................................................................................584 NEUROTOXICITY/a-METHYLDOPAMINE/GLUTATHIONE.................................................................................................. 654 NEUROTOXICITY/ION HOMEOSTASIS/2.5-HEXANEDIONE ................................................................................................ 760 NEUROTOXICITY/NEUROPATHOLOGY/NEUROBEHAVIORAL.......................................................................................... 821 NEUROTOXICITY/PERMETHRIN/RATS ................................................................................................................................... 921 NEUROTOXIC1TY/PERMETHRIN/RATS ...................................................................................................................................922 NEUROTOXICITY/CARPETS/SENSORYIRRITATION ............................................................................................................970 NEUROTOXICITY/CARPETS/FUNCTIONAL OBSERVATIONAL BATTERY ....................................................................... 971 NEUROTOXICITY/AUTOANTIBODY/MERCURY .................................................................................................................. U16 NEUROTOXICITY/AUTOANTIBODY/LEAD............................................................................................................................1117 NEUROTOXICITY/AUTOANTIBODY/CADMIUM .................................................................................................................. H18 NEUROTOXICITY/AUTOANTIBODY/LEAD............................................................................................................................1119 NEUROTOXICITY/QUINOLINIC ACID/COPPER......................................................................................................................1129 NEUROTOXICITY/4-PHENYLCYCLOHEXENE/INHALATION .............................................................................................1237 NEUROTOXICITY/AUTOANTIBOGY/OPIDN..........................................................................................................................1331 NEUROTOXICITY/TOLUENE/TRICHLOROETHYLENE........................................................................................................ 1335 NEUROTOXICITY/DOPAMINE/MDMA ................................................................................................................................... 1351 NEUROTOXICITY/LAZAROID U 74389F ... ...............................................................................................................................1355 NEUROTOXICITY/p-N-METHYLAMINE-L-ALANINE/3' ......................................................................................................... 1369 H74 NEUROTOXICITY/EVOKED POTENTIALS/TEST GUIDELINES ..........................................................................................1J NEUROTOXICITY/METHYLMERCURY/INTRACELLULAR CALCIUM............................................................................... |49f NEUROTOXICrrY/EXCITOTOXINS/NEURODEGENERA'nVEDISEASES ......................................................................... 1573 528 511904 0251 NEUROTOXICITY EVALUATION/RESTRAINT-INDUCED STRESS/CARPET EMISSIONS TESTING ................................. 967 NEUROTOXICITY SCREENING/CHOLINESTERASE INHIBITORS/FUNCTIONAL OBSERVATIONAL BATTERY............ 906 NEUROTOXICITY SCREENING BATTERY/RODENTS/HISTORICAL CONTROL DATA ..................................................... 1375 NEUROTOXICITY SCREENING BATTERY/PESTICIDES/RODENT ........................................................................................1538 NEUROTOXICOLOGY/IN VITRO/AXONAL TRANSPORT .........................................................................................................758 NEUROTOXIN/PROCONVULSANT/CHEMICAL KINDLING ................................................................................................... 1340 NEUROTOXINS/FOB/MOTOR ACTIVITY ..................................................................................................................................1378 NEUROTOXINS/FREERADICALS/EXCITOTOXICITY .............................................................................................................1575 NEUROTRANSMITTERS/PHOSALONE TOXICITY/BEHAVIORAL TOLERANCE .................................................................1358 NEUROTROPHIC FACTORS/NEUROTROPHINS/REGENERATION ............................................................................................. 5 NEUROTROPHINS/REGENERATION/NEUROTROPHIC FACTORS ............................................................................................. 5 NEUROTROPHINS/NERVE GROWTH FACTOR/MAST CELLS ............................................................................................... 1361 NEUROTROPHINS/NEUROPEPTIDES/NERVE GROWTH FACTOR ....................................................................................... 1362 NEUTROPML/PHOSPHOINOSITIDES/PCBS............................................................................................................................... 950 NEUTROPHILS/ADHESION MOLECULES/SILICA......................................................................................................................241 NEUTROPHILS/ENDOTOXIN/EPITHELIALCELLS ....................................................................................................................244 NEUTROPHILS/HEPATOCYTES/NITRIC OXIDE ........................................................................................................................246 NEUTROPHILS/CIGARETTE SMOKE/EPITHELIAL INJURY/REPAIR ..................................................................................... 275 NEUTROPHILS/INFLAMMATION/LAVAGE............................................................................................................................... 276 NEUTROPHILS/POLYCHLORINATED BIPHENYLS/CALCIUM................................................................................................ 948 NEUTROPHILS/ENDOTOXIN/KUPFFES CELLS........................................................................................................................ 1452 NEW METHOD/CORNEAL THICKNESS/EYE IRRITATION ...................................................................................................... 985 NGF/ACRYLAMIDE/PC12.............................................................................................................................................................. 768 NICKEL/RETTNOBLASTOMA GENE/TRANSFORMATION........................................................................................................ 523 NICKEL/TOXICrTY/IN VITRO BACTERIAL ASSAY ..................................................................................................................901 NICKEL/APOPTOSIS .....................................................................................................................................................................1426 NICKEL COMPOUNDS/LUNG CLEARANCE/TOXICOKINETICS ............................................................................................ 903 NICKEL SULFATE/CARCINOGENESIS .......................................................................................................................................902 NICOTNE/C-MYOCELL PROLIFERATION ............................................................................................................................... 427 NICOTINE/AXON BRANCHING/HIPPOCAMPAL NEURONS....................... ::........................................................................ 509 NICOTINE/GLUCURONIDES/BILE ............................................................................................................................................. 1706 NIPECOTAMIDES/AGGREGATION INHIBITORS/ANTIPLATELET ....................................................................................... 1553 NITRIC OXIDE/OZONE/LIVER...................................................................................................................................................... 245 NITRIC OXIDE/NEUTROPHILS/HEPATOCYTES ....................................................................................................................... 246 NITRIC OXIDE/INHIBITION/AMPHIPHILIC DRUGS..................................................................................................................736 NITRIC OXIDE/NTTRIC OXIDE SYNTHASE/TRIMETHYLTIN.................................................................................................. 739 NITRIC OXIDE/SMOKELESS TOBACCO EXTRACT/VITAMIN E SUCCINATE ......................................................................741 NITRIC OXIDE/UVB/SKIN.............................................................................................................................................................. 742 NITRIC OXIDE/TYPE n CELLS/SILICON DIOXIDE....................................................................................................................745 NITRIC OXIDE/LUNG/OZONE..................................................................................................................................................... 1227 NITRIC OXIDE (NO)/CYANIDE/VASCULAR............................................................................................................................... 743 NITRIC OXIDE SYNTHASE/STIMULATION/PHENCYLIDINE.................................................................................................. 735 NITRIC OXIDE SYNTHASE/METALS/INHIBITION ....................................................................................................................737 NITRIC OXIDE SYNTHASE/INHIBmON/PESTICIDES .............................................................................................................. 738 NITRIC OXIDE SYNTHASE/TRIMETHYLTIN/NITRIC OXIDE.................................................................................................. 739 NITRIC OXIDE SYNTHASE/GLUTATHIONE/CYTOKINES........................................................................................................ 740 NITRIC OXIDE SYNTHASE/LTVER/CELL DEATH ......................................................................................................................931 NITRIFICATION/HERBICIDES/NITROGEN-FIXATION.............................................................................................................1435 NITRITE/CYANIDE/METHEMOGLOBIN..................................................................................................................................... 825 NITRITE/DNA DEAMINATION/BUTYL NITRITE........................................................................................................................856 NITROBENZENE/BIOLOGICAL MONITORING/PARA-NITROPHENOL..................................................................................1571 NITROGEN DIOXIDE/SURFACTANTS/INTERFACIAL TRANSFER ..........................................................................................150 NITROGEN DIOXIDE/GLUTATHIONE/PULMONARY ABSORPTION ..................................................................................... 618 NITROGEN DIOXIDE/NASAL TOXICITY/SHEEP...................................................................................................................... 1225 NITROGEN DIOXIDE/CIGARETTE SMOKE/LUNG CLEARANCE............................................................................................1676 NITROGEN-FIXATION/NITRIFICATION/HERBICIDES.......................................................................................................... |43 NITROPRUSSIDE/ENDOTHELIAL CELLS/ELECTRON PARAMAGNETIC RESONANCE................................................ " 7 NITROSAMINE/PLANARIA/CARCINOGENESIS ................................................................................................................. ' ' 4?2 NITROSAMINE/PLACENTA/CARBONYL REDUCTASE....................................................................................................... \3l0 NK CELL/ETHANOL/FLOW CYTOMETRY ............................................................................................................................. ,246 NMDA/EXCITOTOXICITY/GLUTAMATE ............................................................................................................................. ]346 NMDA RECEPTOR/ZINC/LEAD.............................................................................................................................................. ' 25l NMR SPECTROSCOPY/CYANIDE/CELL ENERGY............................................................................................................... 1332 NO SYNTHASE INHIBITORyNG-METHYL-L-ARGININE/ANTIHYPOTENSIVE DRUG .................................................. '' g03 NO2/DUST MITE/IGE .............................................................................................................................................................. . "4|7 NONCANCER/RISK/ASSESSMENT........................................................................................................................................ I592 NONMUTAGENICCARCINOGENS/DNA RECOMBINATION/DELETIONS ....................................................................... 853 NONSTEROIDAL ANTIINFLAMMATORY DRUG/RENAL PAPILLARY NECROSIS/CARCINOGENICITY.................. '' 16fi NONTARGET ORGANISMS/INSECTICIDAL PLANTS/BENEFICIAL PLANTS ................................................................. 1546 NOSE-ONLY UNIT/MIXING/OPTIMUM OPERATING CONDITIONS .................................................................................. ' , 59 NOVEL FLUORESCENT METHOD/DOMOIC ACID/NEUROPATHOLOGY ............................................................................ [0 NRK-49FCELL/ACIVICIN/Y-GLUTAMYLTRANSPEPTIDASE............................................................................................... ... NUCLEAR MAGNETIC RESONANCE SPECTROSC/METABOLISM/2-METHOXYETHANOL............................................ NUCLEAR RECEPTORS/SEIZURES - LINDANE/GENE EXPRESSION ................................................................................... . NUCLEAR TYROSINE KINASES/PHOSPHORYLATION/RNA POLYMERASE B ............................................................... 14, gNUCLEO TRANSLOCATION OF ADDUCTS/LAMIN A/ACETAMINOPHEN:COVALENT BINDING.................................. |691 NUCLEOSOMES/POLYMERASE/BENZO(A)PYRENE...............................................................................................................839 NURSING DISORDER/HORMONE/BEHAVIOR.......................................................................................................................... 219 NUTRmON/CALORIC RESTRICTION/CARCINOGENICITY...................................................................................................932 0-XYLENE/BENZO(A)PYRENE/DNA ADDUCT.......................................................................................................................1293 OCCUPATIONALPHARMACEUTICALS/EXPOSURE LIMITS.............................................................................................. U 52 OCCUPATIONAL EXPOSURE/RISK ASSESSMENT/HAZARD SCREENING ........................................................................ 1150 OCTAMETHYLCYCLOTETRASILOXANE/INHALATION/LIVEREFFECTS ..........................................................................698 OCTANOL/DRUG RESISTANCE/GAP JUNCTIONS .................................................................................................................. 138 OCULAR/EYE/TETRACHLORVTNPHOS..................................................................................................................................... 978 OCULAR/ALDOSE REDUCTASE INHIBITORS/BIOTRANSFORMATION ............................................................................ 1313 OCULAR IRRITATION/EYE/IN VITRO ALTERNATIVES ........................................................................................................ 988 OFFGASSING/CARPETS/IRRITANT........................................................................................................................................... 966 OFLOXACIN/EYE/MONKEYS .....................................................................................................................................................977 OKADAIC ACID/APOPTOSIS/RAS-ONCOGENE........................................................................................................................ 167 OLEFINS/MICRONUCLEUS/IN VIVO........................................................................................................................................1277 OLFACTORY FUNCTION/IDPN/DICHLOBENIL........................................................................................................................297 OLFACTORY TOXICITY/ACRYLIC ACID/NASAL TOXICITY............................................................................................... 1212 OLIGONUCLEOTIDES/CHOLESTEROL-CONJUGATED/CYTOCHROME P450 2B1.............................................................. 102 OLIGONUCLEOTIDES/REGULATION/CYTOCHROME P-450 2E1........................................................................................... 124 ONCOGENE/DIOXIN/CELL PROLIFERATION ........................................................................................................................ 1624 ONCOGENE EXPRESSION/CC14 TOXICITY INHIBITORS/INDUCERS/AP-1 TRANSCRIPTION FACTOR......................... 515 ONCOGENES/MYCOTOXIN/CYTOTOXICITY ......................................................................................................................... 516 ONCOGENES/TRANSGENE/TOXICOLOGY............................................................................................................................... 938 ONCOGENES/CARCINOGENESIS/TCDD..................................................................................................................................1518 ONCOGENICITY/ISOPROPANOL7INHALATION.................................................................................................................... 1219 ONCOGENICITY/METHYLETHYLKETOXIME/INHALATION............................................................................................... 1220 ONCOGENICTTY/INHALATION/SULFURYL FLUROIDE .......................................................................................................1547 OOCYTE/GLUTATHIONE/MICROTUBULE............................................................................................................................... 660 OOCYTE DESTRUCTION/FOLLICULAR DEVELOPMENT/REPRODUCTTVE SYSTEM ...................................................... 213 OPERANT BEHAVIOR/MOTOR ACIWITY/PESTICIDES ........................................................................................................ 293 OPIATE/ELECTROPHORESIS/HIBERNATION ......................................................................................................................... 300 OPIDN/NEUROTOXICTTY/AUTOANTTBOGY.......................................................................................................................... 1331 OPIDN/RATS/NEUROTOXIC ESTERASE..................................................................................................................................1356 OPIDP/PERIPHERAL NERVE/SPINAL CORD............................................................................................................................. 762 530 511904 0253 OPIDP/HUMAN/METHAMIDOPHOS............................................................................................................................................ 1534 OPTIMUM OPERATING CONDITIONS/NOSE-ONLY UNIT/MIXING ........................................................................................ 159 ORALTTOXICITY/SUBCHRONIC TOXICITY ............................................................................................................................... 1595 ORAL MUCOSA/CONTACT HYPERSENSITIVITY/LOCAL LYMPH NODE ASSAY...............................................................1267 ORGAN CULTURE/LUNG/TIO2 ...................................................................................................................................................... 153 ORGANIC CATIONS/PROXIMAL TUBULE/TRANSPORT........................................................................................................... 161 ORGANOCHLORINE/REPRODUCTION/ESTROGEN RECEPTOR ............................................................................................. 227 ORGANOPHOSPHATE/PIPERONYL BUTOXIDE/DEF DEFOLIANT........................................................................................ 1520 ORGANOPHOSPHATE HYDROLYSIS/PARAOXON/A-ESTERASE.......................................................................................... 1297 ORGANOPHOSPHATE HYDROLYSIS/ORGANOPHOSPHORUS HYDROLASE (OPH)/BIODETOXIFICATION .................1527 ORGANOPHOSPHATE INHIBITION/ACETYLCHOLINESTERASE INHIBITION/CHLORPYRIFOS-OXON..........................909 ORGANOPHOSPHATE-INDUCED DELAYED NEUR/PHENYL SALIGENIN PHOSPHATE/HEN ..........................................1532 ORGANOPHOSPHATES/ACETYLCHOLINESTERASE/IMMUNOTOXICOLOGY.................................................................... 414 ORGANOPHOSPHATES/MACROPHAGES/PHAGOCYTOSIS/KILLING....................................................................................415 ORGANOPHOSPHATES/MUSCARINIC RECEPTORS/FUNCTIONAL ENDPOINTS ................................................................ 907 ORGANOPHOSPHATES/CHOLINESTERASES/AVIAN.............................................................................................................. 908 ORGANOPHOSPHATES/p-NAPHTHOFLAVONE/ALIESTERASES........................................................................................... 915 ORGANOPHOSPHATES/MUSCARINIC RECEPTORS/ACETYLCHOLINESTERASE .............................................................. 919 ORGANOPHOSPHATES/MACROPHAGE/HL-6O/DIFFERENTIATTON...................................................................................... 1254 ORGANOPHOSPHATES/PARATHION DESULFURATION/PHOSPHOROTHIONATE METABOLISM..................................1298 ORGANOPHOSPHATES/CHLORPYRIFOS/THERMOREGULATION........................................................................................1354 ORGANOPHOSPHATES/DISPOSmON/PESTICIDE............................................................................................... 1529 ORGANOPHOSPHATES/PREGNANCY/NEUROCHEMISTRY................................................................................................... 1530 ORGANOPHOSPHATES/HEPATIC ALIESTERASES/ACETYLCHOLINESTERASE INHIBITION..........................................1533 ORGANOPHOSPHATES/MILITARY SITES/SOIL CONTAMINANTS........................................................................................ 1635 ORGANOPHOSPHORUS/PRE TREATMENT/PYRIDOSTIGMINE..............................................................................................1536 ORGANOPHOSPHORUS/DEVELOPMENTAL/NEUROCHEMISTRY........................................................................................ 1542 ORGANOPHOSPHORUS ESTERS/MUSCARINIC RECEPTORS/NEUROBLASTOMA CELLS................................................. 920 ORGANOPHOSPHORUS HYDROLASE/CATALYSIS/METAL BINDING MOTIFS .................................................................. 892 ORGANOPHOSPHORUS HYDROLASE (OPH)/BIODETOXIFICATION/ORGANOPHOSPHATE HYDROLYSIS .................1527 ORTHO-QUINONE/PHENOLS/QUINONE METHIDE .................................................................................................................. 359 OSHA/REPRODUCTIVE EFFECTS/HAZARD RANKING.............................................................................................................793 OSTEOBLAST/DIFFERENTIATION/TCDD.................................................................................................................................. 1508 OSTEOCALCIN/LEAD/CALCIUM ................................................................................................................................................. 248 OSTEOCALCIN/LEAD/VITAMIN D RECEPTOR.........................................................................................................................1183 OSTEOCLASTS/CADMIUM/BONE RESORPTION........................................................................................................................ 874 OSTEOPOROSIS/H1STOMORPHOMETRY/MARMOSETS........................................................................................................... 831 OSTEOPOROSIS/BONE METABOLISM/SULFATED POLYSACCHARIDE.............................................................................. 1498 OUTREACH/PRECOLLEGE EDUCATION/UNDERGRADUATE RESEARCH............................................................................ 285 OVALBUMIN/HYPERSENSITTVITY/INFLUENZAVIRUS......................................................................................................... 1612 OVARIAN AHH/CIGARETTE SMOKE/OVARIAN DNA ADDUCTS.......................................................................................... 1677 OVARIAN CELLS/TCDD/REPRESSION ...................................................................................................................................... 1615 OVARIAN DNA ADDUCTS/OVARIAN AHH/CIGARETTE SMOKE.......................................................................................... 1677 OVARIAN TOXICITY/TERATOGENICITY/4-VINYLCYCLOHEXENE ......................................................................................586 OVARY/ESTROGEN RECEPTOR/TCDD........................................................................................................................................730 OVERLOAD/PULMONARY CLEARANCE/PULMONARY INFLAMMATION PARTICLES.....................................................279 OVOTOXICITY/REACTIVE EPOXIDES/4-VINYLCYCLOHEXENE............................................................................................212 OVULATTON/CATECHOLAMINES/METAM SODIUM................................................................................................................ 214 OVULATION/CATECHOLAM1NES/VALPROIC ACID.................................................................................................................215 OXALATE/TRICHLOROACETATE/BROMODICHLOROACETATE.......................................................................................... 1464 OXAMYL/METHOMYL/ATROPINE/MEMANTINE..................................................................................................................... 1545 OXIDANT INJURY/EPITHELIAL BARRIER/PULMONARY ..................................................................................................... 1229 OXIDANT STRESS/DIQUAT/ACETAMINOPHEN........................................................................................................................ 607 OXIDANT TUMOR PROMOTERS/SKIN CELLS/SECOND MESSENGERS .............................................................................. 1496 OXIDATTVE DAMAGE/TRANSCRIPTION FACTOR/METABOLISM......................................................................................... 442 531 511904 0254 OXIDATIVE DAMAGE/PROMOTER REGULATORY ELEMENT/GLUTATHIONE PEROXIDASE.................................... ^ OXIDATIVE DAMAGE/HEPATOCYTES/ESTROGEN.......................................................................................................... ' 4J6 OXIDATIVE DAMAGE/ERYTHROCYTES/PEROXYL RADICAL.......................................................................................... ^ OXIDATIVE DAMAGE/HYDROXYL FREE RADICALS/MTTOCHONDRIA ............................................:......................... ^ OXIDATIVE DAMAGE/DNA NICKING/HYDROXYL RADICAL ............................................................................................ g^ OXIDATIVE DAMAGE/DYES/RNA...........................................................................................................................................' 623 OXIDATIVE DAMAGE/SPIN TRAPS/OZONE............................................................................................................................ 636 OXIDATIVE DAMAGE/PARKINSON'S DISEASE/SPIN TRAPS .........................................................................................' ' j 33fi OXIDATIVE DAMAGE/LIVER/PESTICIDES .......................................................................................................................... ,544 OXIDATIVE DAMAGE/CELLULAR ANTIOXIDANTS/CIGARETTE SMOKE........................................................................ 168, OXIDATTVE INJURY/ALKYLATING AGENT/PRIMARY RENAL CELL CULTURE............................................................ ^ OXIDATIVE INJURY/PLATELETS/MENADIONE.................................................................................................................... 6l6 OXIDATIVE INJURY/MITOCHONDRIA/VITAMIN E............................................................................................................... ... OXIDATTVE INJURY/METHEMOGLOBINEMIA/LIPID PEROXIDATION AND EXERCISE ................................................. . OXIDATIVE INJURY/COLONOCYTES/GLUTATHIONE............................................................................................................ OXIDATTVE INJURY/CARCINOGENESIS/METALS..................................................................................................................!191 OXIDATTVE STRESS/TRANSCRIPTION FACTORS/OXYR........................................................................................................ OXIDATTVE STRESS/MOUSE HEPATOCYTES/THIOLS ...........................................................................................................gQg OXIDATTVE STRESS/HEART/ANTIMONY ............................................................................................................................... . OXIDATTVE STRESS/HYPOXIA/GLUTATHIONE................................................................... OXIDATTVE STRESS/COCAINE/FRUCTOSE............................................................................................................................... OXIDATTVE STRESS/MANGANESE/SUPEROXIDE DISMUTASE...........................................................................................g34 OXIDATTVE STRESS/MELPHALAN/DNA ALKYLATION........................................................................................................ 535 OXIDATTVE STRESS/TUMOR NECROSIS FACTOR/RICIN.......................................................................................................7g! OXIDATIVE STRESS/LIPID METABOLITES/CHROMIUM SALTS.......................................................................................... 1004 OXIDATTVE STRESS/GLUTATHIONE/MERCURY................................................................................................................... 1631 OXYGEN CONSUMPTION/ALCOHOL/KUPFFER CELLS ....................................................................................................... 1453 OXYGEN RADICALS/AGE/HYPEROXIA................................................................................................................................... 601 OXYGEN RADICALS/PHAGOCYTOSIS/LYSOSOMES ............................................................................................................ 631 OXYGEN RADICALS/CADMIUM/GENE MUTATION .............................................................................................................. 849 OXYR/OXIDATTVE STRESS/TRANSCRIPTION FACTORS...................................................................................................... 445 OZONE/LTVER/NITRIC OXIDE.....................................................................................................................................................245 OZONE/INFLAMMATION/STRAIN DIFFERENCES ..................................................................................................................274 OZONE/MACROPHAGES/IMMUNOTOXICITY..........................................................................................................................479 OZONE/STRESS PROTEINS/CELL INJURY................................................................................................................................624 OZONE/OXIDATIVE DAMAGE/SPIN TRAPS............................................................................................................................. 636 OZONE/EXTRAPOLATION/DOSE-EFFECT............................................................................................................................... 1222 OZONE/AGING/CELL PROLIFERATION .................................................................................................................................. 1223 OZONE/AGING/BRONCHO-ALVEOLAR LAVAGE .................................................................................................................1224 OZONE/NITRIC OXIDE/LUNG....................................................................................................................................................1227 OZONE/REACTTVE ABSORPTION/SURFACE LINING LAYER ............................................................................................. 1228 OZONE/SULFURIC ACID/MORPHOMETRY ............................................................................................................................1230 OZONE/PERMEABILITY/IL-1...................................................................................................................................................... 1231 OZONE/PERMEABILITY/TNF...................................................................................................................................................... 1232 OZONE DEPLETING SUBSTANCE REPLACEMEN/R-134A/BEHAVIORAL MEASURES .................................................... 296 OZONE TOXICITY/ANTIOXIDANT PROTECTION/VITAMIN AND SELENIUM....................................................................632 P-450/METABOLIC ACTIVATION/RAT LIVER SLICES.............................................................................................................25 P-450 1AI INDUCTION/PAHS/FISH............................................................................................................................................ 1650 P-450 INDUCTION/CELL ACIDIFICATION/CARCINOGENESIS .............................................................................................677 P-GLYCOPROTEIN/BILE/EXCRETION...................................................................................................................................... 1439 P-GLYCOPROTEIN/EXCRETION/TAMOXIFEN ...................................................................................................................... 1596 P-NITROSOPHENOL/ALCOHOL DEHYDROGENASE/ETHANOL...........................................................................................690 P-N1TROSOPHENOL/ALCOHOL DEHYDROGENASE/HUMAN ISOZYMES ........................................................................1306 P34CDC2/CELL PROLIFERATION/FISH.................................................................................................................................... 1067 P34CDC2 KINASE/RATS/CELLULAR PROLIFERATION.......................................................................................................... 422 532 511904 0255 P34CDC2 KINASE/PHENOBARBITAL/CELL PROLIFERATION........................................................................................... . .423 P45Q/PEROXYGENASE/ARACHIDONIC ACID ...................................................................................................................... . .109 P450/P450HB/P450IIE/ETHANOL/CHROMIUM/CHROMATE/CR(VI)................................................................................... .1007 P5 3/S KIN CANCER/PCR ..................... ............................................................................................................................. . .519 P53/1.3-BUTADIENE/IMMUNOHISTOCHEMISTRY ...............................................................................................;........... ..520 P53/TUMOUR-SUPPRESSOR/CARCINOGENESIS.................................................................................................................. . .521 P53/BENZO(A)PYRENE/TERATOGENESIS ...................................................................................................... ..................... . .940 P53/MDM2 GENE/TCDD ..................................................................................................................................... ..................... .1506 P53 ANTIONCOGENE/HEPATOCARCINOMA/TAMOXIFEN ............................................................................................... .1600 PAHS/IMMUNOTOXICOLOGY/MICE..................................................................................................................................... .. .16 PAHS/FISH/P-450 1A1 INDUCTION......................................................................................................................................... .1650 PAHS/GENOTOXICITY/SEDIMENTS ..................................................................................................................................... .1656 PAHS/BIOMARKERS/FISH ....................................................................................................................................................... .1657 PANCREAS/CELL REPLICATION/PHENOBARBITONE ...................................................................................................... ..436 PANCREAS/MUTATIONS/H-RAS GENE................................................................................................................................. ..513 PANCREATIC ACINAR CELL TUMORS/PEROXISOME PROLIFERATORS/LEYDIG CELL TUMORS............................. .1169 PAPILLOMAVIRUS/CYTOCHROME P-450/HUMAN TISSUES.............................................................................................. .490 PARA-NITROPHENOL/NITROBENZENE/BIOLOGICALMONITORING............................................................................... .1571. PARACETAMOL/CYTOKINES/HEPATOTOXICITY................................................................................................................ . .747 PARAOXON/TOLERANCE/ACETYLCHOUNESTERASE....................................................................................... ............ ..913 PARAOXON/TOLERANCE/ACETYLCHOUNESTERASE...................................................................................................... ..914 PARAOXON/A-ESTERASE/ORGANOPHOSPHATE HYDROLYSIS....................................................................................... .1297 PARAOXON/CHOLINESTERASE INHIBITION/FUNCTIONAL BEHAVIOR......................................................................... .1371 PARAOXON/FISH/ACETYLCHOUNESTERASE...................................................................................................................... .1519 PARAQUAT/IN VITRO TOXICOLOGY/FREE RADICAL SCAVENGERS ............................................................................. .1525 PARATHION/ESTRADIOL/CATECHOLESTROGENS............................................................................................................ .1523 PARATHION/ETHANOL/CYTOCHROME P-450 ...................................................................................................................... .1524 PARATHION DESULFURATION/PHOSPHOROTHIONATE METABOLISM/ORGANOPHOSPHATES............................... .1298 PARKINSON'S DISEASE/SPIN TRAPS/OXIDAnVE DAMAGE ............................................................................................ .1336 PARKINSONISM/MPTP/METHAMPHETAMINE...................................................................................................................... .1576 PAROXON/ANTAGONISM/CARRIER ERYTHROCYTES ...................................................................................................... .1537 PARTIAL HEPATECTOMY/DIOXIN/CELL PROLIFERATION .............................................................................................. .1513 PARTICLE/UPPER RESPIRATORY TRACT/FISCHER 344 RAT ............................................................................................ ..143 PARTICLES/RATS/INTRATRACHEAL..................................................................................................................................... ..154 PARTURITION/DCB/UTERINE CONTRACTION..................................................................................................................... ..226 PATHOLOGY/HEPTA-CDD/TCDD/SUBCHRONIC TOXICITY.............................................................................................. .1040 PATHOLOGY/2,4,6-TRmiTROPHENYLMETHYLNITRAMINE/MUNITIONCHEMICAL .................................................. .1560 PATHOLOGY/IMMUNIZATION/PULMONARY .................................................................................................................... .1669 PB-TK MODELING/3-D VISUALIZATION/TOXICOKINETICS............................................................................................. ...84 PBPK/BREAST MILK/TETRACHLOROETHYLENE .............................................................................................................. ...86 PBPK/DICHLOROMETHANE/ENZYME INHIBITION............................................................................................................ ..376 PBPK/CELL PROLIFERATION/CHEMICAL MIXTURES ....................................................................................................... ..398 PB PK/CHLOROFORM/CANCER RISK..................................................................................................................................... ..542 PBPK/GAS UPTAKE/HALON REPLACEMENTS .................................................................................................................... 1660a PBPK/MODELING/PHARMACOKINETICS.............................................................................................................................. .1715 PBPK MODEL/PYRENE/TOXICOKINETICS............................................................................................................................ ...75 PBPK MODELING/CYTOCHROME P-450/TRICHLOROETHYLENE...................................................... ............................. ...67 PBPK MODELING/ETHYLENE/ETHYLENE OXIDE.............................................................................................................. ...81 PBPK MODELING/RISK ASSESSMENT/2-METHOXYETHANOL ....................................................................................... ...88 PBPK MODELING/VOLATILE ORGANIC CHEMICALS/PERMEABILITY CONSTANTS................................................... ..670 PBPK MODELS/CHLOROFORM/DOSE-RESPONSE.............................................................................................................. ...65 PBPK. INTERSPECIES EXTRAPOLATION/PHARMACOKINETICS 2-METHOXYETHANOL/PHARMACOKINETICS 2- METHOXYACETIC ACI............................................................................................................................................................. . .399 PC 12/NGF/ACRYLAMIDE......................................................................................................................................................... . .768 PC 12 CELLS/2'CH3-MPTP/DlADENOSINETETRAPHOSPHATE........................................................................................... .1337 533 511904 0256 PCB/KUPFFER CELL/TUMOR NECROSIS FACTOR PCB CONGENER #77/ENVIRONMENTAL CONTAMINANT/LIVER ULTRASTRUCTURE................... PCBS/STRUCTURE-INDUCTION/CYP2B1/2................................................................................................ PCBS/STRUCTURE-INDUCTION/CYP2B1/2................................................................................................ PCBS/NEUTROPHIL/PHOSPHOINOSITIDES.............................................................................................. PCBS/NEUROB EHAVIORAL/NEUROPSYCHOLOGICAL TESTS.............................................................. PCBS/METHODS/CONGENER SPECIFIC .................................................................................................... PCBS/TOXIC EQUIVALENCY/TCDD .......................................................................................................... PCBS/ESTROGEN RECEPTOR/ESTRADIOL EQUIVALENTS................................................................... PCBS/NEURONS/MEMBRANE CURRENTS................................................................................................. PCBS/AROCLOR/LIVER ............................................................................................................................... PCBS/RISK ASSESSMENT/REFERENCE DOSE........................................................................................... PCBS/MINK/GREAT LAKES FISH................................................................................................................ PCBS/MINK/GREAT LAKES FISH................................................................................................................ PCBS/DISPOSITION/CYTOCHROME P-450 ................................................................................................. PCBS #77/EROD/CYTOCHROME P-450........................................................................................................ PCBTF/HEPATOCYTE HYPERTROPHY/INHALATION TOXICITY.......................................................... PCDD/PCDF/TOXICOKINETICS/MODEL SIMULATION........................................................................... PCNA/CELL PROLIFERATION/HEPATOTOXICITY................................................................................... PCR/P53/SKIN CANCER.......................................................... .................................................................... PCR/SEQUENCING/DNA ADDUCTS............................................................................................................ PDE HI INHIBITOR/ARTERIOPATHY/HAEMODYNAMIC ........................................................................ PENTACHLOROANISOLE/EXCRETION/METABOLISM........................................................................... PENTACHLOROPHENOL/PEROXIDASE/FREE RADICALS ...................................................................... PENTACHLOROPHENOIVMITOCHONDRIAL TOXICITY/GLUTATHIONE S-TRANSFERASE ............ PENTAMIDINE/NEPHROTOXICrrY/IN VITRO........................................................................................... PEPTIDE/CYTOCHROME P-450/ANTIBODIES ........................................................................................... PERCHLOROMETHYLMERCAPTAN/FOLPET TECHNICAL/INHALATION........................................... PERCUTANEOUS ABSORPTION/GASOLINE OXYGENATE/METHYL TERT-BUTYL ETHER (MTBE) PERCUTANEOUS ABSORPTION/PESTICIDES/CLOTH............................................................................. PERCUTANEOUS ABSORPTION/IN VITRO TOXICOLOGY/SKIN MODEL............................................. PERCUTANEOUS ABSORPTION/2,4-D/SOIL............................................................................................... PERCUTANEOUS ABSORPTION/TOXICOKINETICS/SULFUR MUSTARD............................................. PERFLUOROCARBOXYLIC ACIDS/GLUCOSE TRANSPORT/PEROXISOME PROUFERATORS ........ PERFLUORODECANOIC ACID/GENE EXPRESSION/PEROXISOME PROLIFERATOR......................... PERFLUORODECANOIC ACID/ACYL-COA BINDING PROTEIN/FATTY ACID-BINDING PROTEIN .. PERFORMANCE ENHANCEMENT/IMPROVED GRADES/EDUCATION/TEACHING ........................... PERICENTRAL TOXICrTY/TNF-a/HEPATOCYTES ................................................................................... PERIPHERAL NERVE/SPINAL CORD/OPIDP............................................................................................... PERIPHERAL NEUROPATHY/GAP-43/ACRYLAMIDE ............................................................................. PERIPHERALNEUROPATHY/DEMYELINATTON/2',3'-DIDEOXYINOSINE........................................... PERMEABILITY/PHARMACOKINETICS/DERMAL................................................................................... PERMEABILITY/IL-1/OZONE........................................................................................................................ PERMEABILITY/TNF/OZONE........................................................................................................................ PERMEABILITY CONSTANTS/PBPK MODELING/VOLATILE ORGANIC CHEMICALS....................... PERMETHRIN/RATS/NEUROTOXICITY .................................................................................................... PERMETHRIN/RATS/NEUROTOXiaTY .................................................................................................... PEROXIDASE/FREE RADICALS/PENTACHLOROPHENOL...................................................................... PEROXIDASES/TRANSPLACENTAL/5,8.11,14-EICOSATETRAYNOIC ACID....................................... PEROXISOME/YEAST/CADMIUM................................................................................................................ PEROXISOME/LIVER/HYPOLIPIDEMIC .................................................................................................... PEROXISOMEPROLIFERATION/UVER/DI-(2-ETHYLHEXYL)ADIPATE.............................................. PEROXISOME PROLIFERATION/VITAMIN A/CIPROFIBRATE................................................................ PEROXISOME PROLIFERATION/AROMATASE/C8................................................................................. PEROXISOME PROLIFERATION/CELL PROLIFERATION/CARCINOGENSIS ..................................... 1064 1459 111 -.120 950 1062 1063 1065 1066 -1349 -1458 -1593 -1643 .1644 1711 116 -1213 .1045 -.421 .519 -.858 .1483 .1714 .1077 .1455 ..532 ...92 .1662 ..336 ..348 ..349 ..663 ..669 .1079 ..440 .1099 ..286 .1444 .762 ..451 ..524 ..668 .1231 .1232 ..670 ..921 ..922 .1077 . .588 ..873 .1100 . .957 .1101 .1163 .1166 534 0257 51194 PEROXISOME PROLIFERATION/LIVER/METHYLCLOFENAPATE....................................................................................... U 67 PEROXISOME PROLIFERATION/TROUT/DEHYDROEPIANDROSTERONE...........................................................................1171 PEROXISOME PROLIFERATION/CYTOCHROME P-450/TCDD................................................................................................1510 PEROXISOME PROLIFERATION/PESTICIDES/CYTOCHROME P-450 .................................................................................... 1522 PEROXISOME PROLIFERATOR/PERFLUORODECANOIC ACID/GENE EXPRESSION...........................................................440 PEROXISOME PROLIFERATORS/UVER SLICE/BILE...................................................................................................................36 PEROXISOME PROLIFERATORS/PERFLUOROCARBOXYLIC ACIDS/GLUCOSE TRANSPORT ........................................1079 PEROXISOME PROLIFERATORS/GEMFIBROZIL/FATTY ACID OXIDATION.......................................................................1098 PEROXISOMEPROLIFERATORS/4-METHYLPYRAZOLE/PROTEINKINASEC .......................................................... 1165 PEROXISOME PROLIFERATORS/LEYDIG CELL TUMORS/PANCREATIC ACINAR CELL TUMORS................................ 1169 PEROXISOMEPROLIFERATORS/INITIATION/PROMOTION/DIETHYL/DIMETHYL-PHTHALATE ..................................1170 PEROXISOME PROLIFERATORS/WY 14,643/CARCINOGENESIS............................................................................................1172 PEROXISOMES/CALCIUM/CANCER .......................................................................................................................................... 1096 PEROXISOMES/CIPROFIB RATE/ANALOGUES......................................................................................................................... 1097 PEROXYGENASE/ARACHIDONIC ACID/P450 ......................................................................... 109 PEROXYL RADICAL/OXTOATTVE DAMAGE/ERYTHROCYTES............................................................................................... 600 PERSISTANCE (T l/2yACRYLONITRILE/TROUT.......................................................................................................................1713 PESTICIDE/ORGANOPHOSPHATES/DISPOSITION...................................................................................................................1529 PESTICIDE MDCTURES/SYSY CELL LINE/ACETYLCHOLINESTERASE ACTIVITY.............................................................1353 PESTICIDES/INTERACTIONS/MOTOR ACTIVITY...................................................................................................................... 292 PESTICIDES/OPERANT BEHAVIOR/MOTOR ACTIVITY............... 293 PESTICIDES/CLOTH/PERCUTANEOUS ABSORPTION...............................................................................................................348 PESTICIDES/NITRIC OXIDE SYNTHASE/INHIBmON...............................................................................................................738 PESTICIDES/REGULATORY/ADVERSE EFFECTS...................................................................................................................... 795 PESTICIDES/LIVER ........................................................................................................................................................................ 924 PESTICIDES/CARBOFURAN/METABOLISM....................................................................................... 1521 PESTICIDES/CYTOCHROME P-450/PEROXISOME PROLIFERATION....................................................................................1522 PESTICIDES/CARCINOGENICITY/CHIRAL................................................................................................................................ 1531 PESTICIDES/RODENT/NEUROTOXICITY SCREENING BATTERY ........................................................................................1538 PESTICIDES/TOXIC EQUIVALENCY FACTORS/RISK ASSESSMENT....................................................................................1540 PESTICIDES/HUMAN TISSUES/CARCINOGENESIS .................................................................................................................1541 PESTICIDES/OXIDATIVE DAMAGE/UVER .............................................................................................................................. 1544 PESTICIDES/VALIDATION/CLOTH PATCH TECHNIQUES ..................................................................................................... 1660 PESTICIDES/INSECTICIDES/RESISTANCE/MULTIDRUG RESISTANCE (MDR) ...................................................................1543 PETROLEUM/MICE/ACUTE...........................................................................................................................................................687 PETROLEUM/COMBUSTION/POLYCYCLIC AROMATIC HYDROCARBONS .......................................................................1658 PHAGOCYTOSIS/MICROGRAVTTY/MACROPHAGES................................................ 407 PHAGOCYTOSIS/LYSOSOMES/OXYGEN RADICALS .............................................................................................................. 631 PHAGOCYTOSIS/LEAD/MACROPHAGES....................................................................................................................................898 PHAGOCYTOSIS/KILLING/ORGANOPHOSPHATES/MACROPHAGES....................................................................................415 PHARMACEUTICAL INERTS/EXCIPIENTS/SAFETY GUIDELINES ......................................................................................... 796 PHARMACEUTICALS/REGULATORY/DATABASE.................................................................................................................... 797 PHARMACEUTICALS/CARCINOGENICITY/DATABASE........................................................................................................... 798 PHARMACEUTICALS/CARCINOGENICITY/DATABASE........................................................................................................... 799 PHARMACEUTICALS/EXPOS URELIMITS/OCCUPATTONAL..................................................................................................1152 PHARMACOGENETIC/METABOLISM IN PREGNANCY/METHOXYPHENAMINE............................................................... 1712 PHARMACOGENETICS/ENVIRONMENT/HYPERSENSITTVITY.............................................................................................. 1268 PHARMACOKINETIC MODEL/CHLOROFORM/DOSIMETRY..................................................................................................... 77 PHARMACOKINETIC MODELING/TRICHLOROETHYLENE/CARBON TETRACHLORIDE ................................................... 78 PHARMACOKINETIC MODELING/TRICHLOROETHYLENE/METABOLISM.........................................................................1084 PHARMACOKINETIC MODELS/RISK ASSESSMENT/LEAD ....................................................................................................... 55 PHARMACOKINETIC MODELS/ABSORPTION/LEAD.................................................................................................................562 PHARMACOKINETICS/LEAD/PREGNANCY.................................................................................................................................. 54 PHARMACOKINETTCS/HCFC-123/HALOTHANE.......................................................................................................................... 66 PHARMACOKINETICS/ACRYLONITRILE/CYANOETHYLENE OXIDE...................................................................................... 76 53S 511904 0258 PHARMACOKINETICS/DISPOSmON/METABOLISM....................................................................................................... PHARMACOKINETICS/AMYOTROPHIC LATERAL SCLEROSIS/INSULIN-LIKE GROWTH FACTOR ................. 377 PHARMACOKINETICS/TRICHLOROACETATE (TCAyDICHLOROACETATE (DCA)................................................. ' 3g PHARMACOKINETICS/MONKEYS/METHANOL............................................................................................................. .'. 392 PHARMACOKINETICS/DERMAL/PERMEABILITY............................................................................................................... 66g PHARMACOKINETICS/AGING/TCDD ................................................................................................................................... 1046 PHARMACOKINETICS/POLYCHLORINATED BIPHENYLS/RATS.................................................................................... t059 PHARMACOKINETICS/PBPK/MODELING.............................................................................................................................. 17t5 PHARMACOKINETICS/RATS/DEET........................................................................................................................................... PHARMACOKINETICS/SMALLINTESTINE/BIOTRANSFORMATION................................................................................ 1725 PHARMACOKINETICS 2-METHOXYACETIC ACI/PBPK. INTERSPECIES EXTRAPOLATION/PHARMACOKINETICS 2-METHOXYETHANOL............................................................................................................................................................. . PHARMACOKINETICS 2-METHOXYETHANOL/PHARMACOKINETICS 2-METHOXYACETIC ACI/PBPK, INTERSPECIES EXTRAPOLATION .......................................................................................................................................... 399 PHARMACOKINETICS/DISPOSITION/DOXORUBICIN/LIPOSOME........................................................................................ 813 PHARMACOKINETICS/TOXICOKINETICS/ARSENIC/GLUTATHIONE................................................................................... . PHARMACOKINETICS/TOXICOKINEnCS/CARBONTETRACHLORIDE/SENSmVTTY ANALYSIS ................................. 74 PHARMACOKINETICS/TOXICOKINETICS/ETHAMBUTOL/MYCOBACTERIUM AVIUM................................................... 533 PHARMACOLOGY/CHOUNERGIC/ENZYME ASSAYS .......................................................................................................... 1124 PHENCYCLIDINE/TEMPORAL RESPONSE DIFFERENTIATION/METHAMPHETAMINE ................................................... 305 PHENCYCLIDINE/MK801/INOSn'OL POLYPHOSPHATES ......................................................................................................804 PHENCYUDINE/NITRIC OXIDE SYNTHASE/STIMULATION..................................................................................................735 PHENOBARBITAL/MICE/CYTOCHROME P4502B1 ....................................................................................................................117 PHENOBARBITAL/CELL PROLIFERATION/P34CDC2 KINASE................................................................................................423 PHENOBARBITAL/BRDU/CELL PROLIFERATION ..................................................................................................................1569 PHENOBARBITONE/PANCREAS/CELLREPLICATION ........................................................................................................... 436 PHENOLS/QUINONE METHIDE/ORTHO-QUINONE ................................................................................................................. 359 PHENOLS/KINETICS/HYDROQUINONE .....................................................................................................................................391 PHENOLS/FREE RADICALS/ANTIOXIDANT ............................................................................................................................1579 PHENOXYL RADICAL/THIOLS/PROTEIN OXIDATION............................................................................................................364 PHENOXYL RADICAL/VITAMIN E/HEART ...............................................................................................................................612 PHENYL SALIGENIN PHOSPHATE/HEN/ORGANOPHOSPHATE-DMDUCED DELAYED NEUR .........................................1532 PHENYL-2-HYDROXYETHYL CYSTEINE/RENAL PROXIMAL TUBULE/CYTOTOXICITY ................................................ 163 PHENYLENEDIAMINE/STRUCTURE-ACnVITY/MUTAGENICITY.........................................................................................847 PHENYLPROPANOLAMINE/CARDIOVASCULAR/HYPERTENSION..................................................................................... 1488 PHENYTOIN/EMBRYO CULTURE/GLUTATHIONE....................................................................................................................589 PHEONOBARBITAL/CYTOCHROME P-450/ALLIGATOR............................................................................................................97 PHOSALONE TOXICITY/BEHAVIORAL TOLERANCE/NEUROTRANSMITTERS ................................................................ 1358 PHOSGENE/ALVEOLAR MACROPHAGES/TUMOR NECROSIS FACTOR-ALPHA ............................................................... 752 PHOSGENE/LUNG INJURY/PULMONARY EDEMA.................................................................................................................. 1200 PHOSPHATIDYLINOSITOL/ALUMINUM/PHOSPHOLIPASEC ............................................................................................... 1366 PHOSPHODIESTERASE/LEAD/RETINA......................................................................................................................................1121 PHOSPHOINOSITIDE METABOLISM/COCAINE/DEVELOPMENTAL NEUROTOXICITY ...................................................1368 PHOSPHOINOSITTDES/PCBS/NEUTROPHIL............................................................................................................................... 950 PHOSPHOLIPASE A2/KIDNEY/CELL DEATH............................................................................................................................. 929 PHOSPHOLIPASE C/PHOSPHATIDYLINOSITOL/ALUMINUM ............................................................................................... 1366 PHOSPHOLIPIDOSIS/IN VITRO/MACROPHAGES ...................................................................................................................... 330 PHOSPHOLIPIDOSIS/CLORPHENTERMINE/MACROPHAGES .................................................................................................331 PHOSPHOLIPIDOSIS/IN VITRO/MACROPHAGES ...................................................................................................................... 332 PHOSPHOLIPIDS/PORPHYRIA/HEXACHLOROBENZENE....................................................................................................... 1073 PHOSPHOLIPIDS & CHOLESTEROL/DIMETHYLBENZ(A)ANTHRACENE/ETHANOL-INDUCED PROMOTION ..............468 PHOSPHOROTHIOATE OLIGONUCLEOTIDE/RAT CYP1A1/NEGATIVE REGULATORY ELELMENT ............................... 125 PHOSPHOROTHIONATEMETABOLISM/ORGANOPHOSPHATES/PARATHION DESULFURATION..................................1298 PHOSPHORYLATION/GAP JUNCTIONS/TUMOR PROMOTERS................................................................................................135 PHOSPHORYLAnON/MICROTUBULES/CYTOSKELETON/ACRYLAMIDE............................................................................ 267 536 511904 0259 PHOSPHORYLATION/IMMUNOTOXICITY/POLYCYCLIC AROMATIC HYDROCARBONS ................................................ 947 PHOSPHORYLATION/RNA POLYMERASE II/NUCLEAR TYROSINE KINASES ...................................................................1418 PHOSPHORYLATION/APOPTOSIS/CALCIUM ...........................................................................................................................1419 PHOSPHOTYROSINE/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN/EPIDERMAL GROWTH FACTOR RECEPTOR..........724 PHOTOCHEMICAL MAPPING/LMPCR/DNA MODIFICATION................................................................................................. 857 PHOTOTOXICITY/IN VITRO/DERMATOTOXICOLOGY.............................................................................................................333 PHOTOTOXICITY/IN VITRO/HUMAN SKIN ................................................................................................................................347 PHOTOVOLTAIC MATERIALS/REPRODUCTIVE TOXICITY/DEVELOPMENTAL TOXICITY .............................................581 PHOTOVOLTAIC METALS/DEVELOPMENTAL TOXICITY/HEMATOLOGIC TOXICITY ................................................... 1019 PHOTOVOLTAIC METALS/REPRODUCTTVE TOXICITY/DEVELOPMENTAL TOXICITY................................................... 1020 PHYLOGENY/BIODEGRADATION/MYCOBACTERIA............................................................................................................. 1630 PHYSIOLOGIC-PHARMACOKINETICMODEL/DDS/PLASTICS ................................................................................................. 79 PHYSIOLOGY/IN VITRO/METABOLISM.................................................................................................................................... 1308 PICLORAM/DEVELOPMENTALTOXICITY/TOXICITY .............................................................................................................579 PIM-1/KERATINOCYTES/IMMORTALIZED ................................................................................................................................518 PIPERONYL BUTOXIDE/DEF DEFOLIANT/ORGANOPHOSPHATE........................................................................................1520 PIROXICAM/DIFLUOROMETHYLORNITHINE/DFMO...............................................................................................................811 PITUITARY HORMONES/TESTICULAR TUMORS/TESTES.......................................................................................................460 PKC/CELL CYCLE/TCDD ............................................................................................................................................................. 1511 PKC INHIBITOR/SEX DIFFERENCES/HEPATIC CYTOLETHALITY........................................................................... 322 PLACENTA/PROSTACYCLIN/METALS....................................................................................................................................... 218 PLACENTA/DIDEOXYINOSINE/ANTI-HIV........................................................... 525 PLACENTA/ANTI-HIV/TOXICITY................................................................................................................................................. 526 PLACENTA/CARBONYL REDUCTASE/NITROSAMINE........................................................................................................... 1310 PLANAR PCBS/MARINE MAMMALS/POLYCHLORINATED BIPHENYLS ............................................................................ 1647 PLANARWCARCINOGENESIS/NITROSAMINE ........................................................................................................................ 472 PLANARIA/AIRBORNE (OR ATMOSPHERIQ/POLYCHLORINATED BIPHENYLS...............................................................1060 PLANTS/CYTOCHROME P-450/ALKOXYRESORUFIN ETHERS................................................................................................122 PLASMALYTOSIS/POPLITEAL LYMPH NODE ASSAY/PROCAINAMIDE ............................................................................ 1259 PLASMINOGEN ACTIVATOR/IMMUNOGENICITY/PRIMATE ................................................................................................. 819 PLASTICS/PHYSIOLOGIC-PHARMACOKINETIC MODEL/DDS ................................................................................................. 79 PLASnCS/BIOAVAILABILITY/BIODEGRADATION.................................................................................................................1659 PLATELETS/MENADIONE/OXIDATIVE INJURY........................................................................................................................ 616 PLATELETS/ENDOTOXIN/LIVER................................................................................................................................................. 682 PLATELETS/A-NAPTHLISOTHIOCYANATE/LIVER................................................................................................................. 1437 PLATINUM/BIOTRANSFORMATIONAVR-2721 .........................................................................................................................1707 POLYALKYLENE GLYCOL (PAG)/EXPOSURE ASSESSMENT/PULMONARY TOXICITY................................................... 1673 POLYCHLORINATED BIPHENY 1/RESPONSE SURFACE METHODOLOGY/STRUCTURE ACTIVITY RELATIONSHIPS....................................................................................................................................................... 538 POLYCHLORINATED BIPHENYLS/LYMPHOKINES/IMMUNE SUPPRESSION .........................................................................17 POLYCHLORINATED BIPHENYLS/GROWTH/ENDOCRINE ..................................................................................................... 222 POLYCHLORINATED BIPHENYLS/CALCIUM/NEUTROPHILS................................................................................................. 948 POLYCHLORINATED BIPHENYLS/ESTROGENIC/THYROTOXIC.......................................................................................... 1058 POLYCHLORINATED BIPHENYLS/RATS/PHARMACOKINETICS.......................................................................................... 1059 POLYCHLORINATED BIPHENYLS/PLANARIA/AIRBORNE (OR ATMOSPHERIC)............................................................... 1060 POLYCHLORINATED BffHENYLS/STRUCTURE-ACnVITY/3H-PHORBOL ESTER BINDING............................................1352 POLYCHLORINATED BIPHENYLS/TYROSINE HYDROLAYSE/LASER-SCANNING CONFOCAL MICROSCOPY..........1372 POLYCHLORINATED BIPHENYLS/PLANAR PCBS/MARINE MAMMALS .............................................................................1647 POLYCLONAL ANTIBODY RESPONSE/2-METHOXYETHANOL/RAT LYMPH NODE CELLS............................................1396 POLYCYCLIC AROMATIC HYDROCARBONS/INDUCTION/CYP1A2 ......................................................................................496 POLYCYCLIC AROMATIC HYDROCARBONS/POLYCYLIC ORGANIC MATTER/RISK ASSESSMENT..............................537 POLYCYCLIC AROMATIC HYDROCARBONS/IMMUNOSUPPRESSION/STRUCTURE ACTIVITY..................................... 755 POLYCYCLIC AROMATIC HYDROCARBONS/PHOSPHORYLATION/IMMUNOTOXICITY................................................. 947 POLYCYCLIC AROMATIC HYDROCARBONS/CALCIUM/IMMUNOTOXICITY .................................................................... 951 POLYCYCLIC AROMATIC HYDROCARBONS/CALCIUM/IMMUNOTOXICITY .................................................................... 953 537 511904 0260 POLYCYCLIC AROMATIC HYDROCARBONS/DNA SYNTHESIS/HEPATOCYTES............................................................. . POLYCYCLIC AROMATIC HYDROCARBONS/TCDD/IN VITRO ........................................................................................ , 5,4 POLYCYCLIC AROMATIC HYDROCARBONS/COMPLEX MIXTURES/HALOGENATED HYDROCARBONS..................i563 POLYCYCLIC AROMATIC HYDROCARBONS/PETROLEUM/COMBUSTION ...................................................................... 658 POLYCYLIC ORGANIC MATTER/RISK ASSESSMENT/POLYCYCLIC AROMATIC HYDROCARBONS.............................537 POLYMERASE/BENZO(A)PYRENE/NUCLEOSOMES ............................................................................................................... 839 POLYNUCLEAR AROMATIC HYDROCARBONS/METABOLISM/BIOALKYLATION.......................................................... 1290 POLYOXYETHYLENE SORBITAN MONOLAURATE/POLYOXYETHYLENE SORBITAN MONOOLEATE/ DEVELOPMENT ..........................................................................................................................................................................582 POLYOXYETHYLENE SORBITAN MONOOLEATE/DEVELOPMENT/POLYOXYETHYLENE SORBITAN MONOLAURATE......................................................................................................................................................................... . POLYSORBATES/CILIA/TRACHEA .......................................................................................................................................... ... POPLITEAL LYMPH NODE ASSAY/FLOW CYTOMETRY ..................................................................................................... ... POPLITEAL LYMPH NODE ASSAY/PROCAINAMIDE/PLASMALYTOSIS ........................................................................... 1259 PORPHYRIA/HEXACHLOROBENZENE/ALCOHOL.................................................................................................................107i PORPHYRIA/ESTRADIOL/HEXACHLOROBENZENE..............................................................................................................1072 PORPHYRIA/HEXACHLOROBENZENE/PHOSPHOLIPIDS...................................................................................................... IO73 PORPHYRIA/LIVER/DOG ................................................................................................................................ 1104 PORPHYRIA/BINDING/HEXACHLOROBENZENE.............. 1698 PORPHYRIN/DOG HEPATOCYTE/FERROCHELATASE ........................................................................................................... 703 PORPHYRINS/ENVIRONMENTAL TOXICOLOGY/BIOLOGIC MARKERS ........................................................................... 1639 POSITIVE CONTROL STUDY/DEVELOPMENTAL NEUROTOXICITY/METHOD VALIDATION ...................................... 1377 POSTNATAL DEVELOPMENT/CARBON TETRACHLORIDE/TISSUE REPAIR..................................................................... 1461 POTABLE WATER/ACETONE/RISK ASSESSMENT................................................................................................................... 554 POTASSIUM CHANNELS/PRIMARY NEURONAL CELL CULTURE/PYRETHROID INSECTICIDES .................................1539 POTASSIUM OCTATITANATE/INHALATION TOXICOLOGY/FIBROUS AEROSOL............................................................1672 POTENTIATION/HEPATOTOXICITY/CARBONTETRACHLORIDE ...................................................................................... 1051 PRAVASTATIN/METABOLIC SUPPLEMENTATION/MYOTOXICITY ....................................................................................818 PRE TREATMENT/PYRIDOSTIGMINE/ORGANOPHOSPHORUS............................................................................................ 1536 PRECLINICAL SAFETY/BRAIN NATRIURETIC PEPTIDE (BNP)/BIOTECHNOLOGY........................................................... 182 PRECLINICAL TOXICITY STUDY/NEUROBEHAVIORAL/IBOGAINE HC1 ...........................................................................827 PRECLINICAL TOXICITY STUDY/NEUROBEHAVIORAL/IBOGAINE HC1 .......................................................................... 828 PRECOLLEGE EDUCATION/UNDERGRADUATE RESEARCH/OUTREACH.......................................................................... 285 PREDICTIVE MODELS/RISK ASSESSMENT/BLOOD LEAD....................................................................................................... 57 PREDISPOSITION/CARCINOGENESIS/SUSCEPTIBILITY........................................................................................................1140 PREDNISOLONE/HOST RESISTANCE/IMMUNOMODULATION ........................................................................................... 408 PREGNANCY/PHARMACOKINETICS/LEAD................................................................................................................................ 54 PREGNANCY/DELAYED OVULATION/THIRAM.......................................................................................................................216 PREGNANCY/KINETICS/LEAD....................................................................................................................................................220 PREGNANCY/CYTOCHROME P-450/HEXACHLOROBIPHENYL .......................................................................................... 1061 PREGNANCY/AH LOCUS/DNA ADDUCTS ............................................................................................................................... 1281 PREGNANCY/LEAD/MENOPAUSE.............................................................................................................................................1385 PREGNANCY/NEUROCHEMISTRY/ORGANOPHOSPHATES.................................................................................................. 1530 PRIMARY CULTURED HEPATOCYTES/GLUTATHIONE S-TRANSFERASE/RABBIT ........................................................1314 PRIMARY CULTURES/SURFACTANTS/DERMATOTOXICITY................................................................................................351 PRIMARY NEURONAL CELL CULTURE/PYRETHROID INSECTICIDES/POTASSIUM CHANNELS .................................1539 PRIMARY RENAL CELL CULTURE/OXIDATIVE INJURY/ALKYLATING AGENT...............................................................605 PRIMATE/CTP-450/ALDOSE REDUCTASE INHIBITOR............................................................................................................. 91 PRIMATE/PLASMINOGEN ACTTVATOR/IMMUNOGENICITY ................................................................................................819 PRIORmES/COMPARATTVE/ENNVIRONMENTAL POLICY....................................................................................................792 PROBABILISTIC RISK ASSESSMENT/STOCHASTIC RISK ASSESSMENT/ARSENIC........................................................... 551 PROBLEM-BASED LEARNING/COLLABORATIVE LEARNING/ENHANCED LEARNING................................................... 287 PROCAINAMIDE/PLASMALYTOSIS/POPLITEAL LYMPH NODE ASSAY ........................................................................... 1259 PROCONVULSANT/CHEMICAL KINDLING/NEUROTOXIN .................................................................................................. 1340 PROGENITOR CELLS/STEM CELLS/HEMATOPOIETIC/BONE MARROW/ANTIPSYCHOTIC/OLANZAPINE ..................1549 538 511904 0261 PROGESTERONE/HEAVY METALS/GRANULOSA .................................................................................................................... 327 PROGRAMMED CELL DEATH/FLOW CYTOMETRY/MYCOTOXIN ...................................................................................... 1423 PROGRESSION/ALTERED ENZYME PHENOTYPE/HEPATOCARCINOGENESIS .................................................................. 964 PROLACTTN/FESCUE/ERGOTS ............................. ...................................................................................................................784 PROLACTTN/APOPTOSIS/TCDD ..................................................................................................................................................1159 PROLACTTN/LYMPHOCYTES/COCAINE.................................................................................................................................... 1399 PROLIFERATION/MESANGIAL/B ENZO(A)PYRENE..................................................................................... 165 PROLIFERATION/PROMOTION/THYROID..................................................................................................................................426 PROLIFERATION/ACETAMINOPHEN/DNA DAMAGE...............................................................................................................430 PROLIFERATION/LIVER/TAMOXIFEN ...................................................................................................................................... 1598 PROMOTER REGULATORY ELEMENT/GLUTATHIONE PEROXIDASE/OXIDATIVE DAMAGE......................................... 444 PROMOTION/THYROID/PROLIFERATION..................................................................................................................................426 PROMOTION/CIGARETTE-SMOKE-CONDENSATE/ANIMAL-MODEL................................................................................... 462 PROOXIDANTS/RENAL PROXIMAL TUBULES/CYCLOSPORIN A ......................................................................................... 613 PROPAGULE/COLONY FORMING UNITS (CFU'SVRESPIROMETER......................................................................................1629 PROPANIL/STEMCELL/HEMOPOIESIS ......................................................................................................................................1558 PROPELLANT/XM46/TERATOLOGY ........................................................................................................................................... 585 PROPIDIUM IODIDE/CYTOTOXICITY ASSAYmJMOR NECROSIS FACTOR ........................................................................406 PROPIONIC ACID/FORESTOMACH/CELL PROLIFERATION ...................................................................................................429 PROPOFOL/VERAPAMEL/XYLAZINE/KETAMINE...................................................................................................................... 805 PROPYLENE GLYCOL/LIPID PEROXIDATION/CELL INIURY ..................................................................................................164 PROSTACYCLIN/METALS/PLACENTA....................................................................................................................................... 218 PROSTAGLANDIN/BEHAVIOR/LIPOPOLYSACCHARIDE........................................................................................................ 291 PROSTAGLANDIN SYNTHESIS INHIBITOR/CYTOCHROME P-450 INDUCTION/TOXICOKINETICS................................. 705 PROTEASES/TCDD/THYMUS....................................................................................................................................................... 1626 PROTEASES/KERATINOCYTES/TCDD ...................................................................................................................................... 1627 PROTEIN ADDUCT/METHYL DITHIOCARBAMATE/ISOTHIOCYANATE ............................................................................ 1697 PROTEIN ADDUCTS/MENTHOFURAN/IMMUNOCHEMISTRY.................................................................................................365 PROTEIN ADDUCTS/METHYLENEDIPHENYL DIISOCYANTE (MDiyBIOMARKERS.........................................................1411 PROTEIN ADDUCTS/LIVER/DICLOFENAC............................................i................................................................................ 1685 PROTEIN ADDUCTS/ELECTROSPRAY MASS SPECTROMETRY/QUINONE METHIDES ...................................................1696 PROTEIN ADDUCTS (TFA ADDUCTSVE-LYSINE ACYLASE/HALOTHANE ..........................................................................679 PROTEIN CHANGES/LIVER/CIPROFIBRATE ............................................................................................................................ 1162 PROTEIN KINASE/CARCINOGENESIS/DICHLOROACETATE.................................................................................................. 960 PROTEIN KINASE C/ACROLEIN/ALDEHYDES ..........................................................................................................................464 PROTEIN KINASE C/HIPPOCAMPUS/LEAD ................................................................................................................................503 PROTEIN KINASE C/TUMOR PROMOTION/9-ANTHRONES.....................................................................................................676 PROTEIN KINASE C/2-ACETYLAMINOFLUORENE/IMMUNOSUPPRESSION........................................................................946 PROTEIN KINASE C/PEROXISOME PROLIFERATORS/4-METHYLPYRAZOLE .................................................................. 1165 PROTEIN KINASES/LEAD/HIPPOCAMPAL NEURONS.............................................................................................................. 501 PROTEIN OXIDATION/PHENOXYL RADICAL/THIOLS ............................................................................................................ 364 PROTEIN OXIDATION/GLUTAMINE SYNTHETASE/GLUTATHIONE..................................................................................... 599 PROTEIN OXIDATION/DIQUAT/MECHANISMS ........................................................................................................................610 PROTEIN PHOSPHATASE/MICROCYSTIN/CALYCULIN A ..................................................................................................... 1094 PROTEIN SECRETION/SMOOTH MUSCLE CELLS/CELL PROLIFERATION............................................................................420 PROTEIN STRUCTURE/VENOM/WASP ....................................................................................................................................... 785 PROTEIN SYNTHESIS/LUNG SLICES/ALKYLPHENOL .............................................................................................................. 27 PROTEIN SYNTHESIS/THYMOCYTES/APOPTOSIS...................................................................................................................1426 PROTEINS/ALLERGY/MODELS................................................................................................................................................... 1256 PROTEOLYSIS/TCDD/AH RECEPTOR ........................................................................................................................................1518 PROTEOTOXICITY/STRESS 70/STRESS PROTEINS.................................................................................................................. 1434 PROTO-ONCOGENE/BENZO(A)PYRENE/SMOOTH MUSCLE CELLS ..................................................................................... 511 PROTO-ONCOGENE/CADMIUM/METALLOTHIONEIN ...........................................................................................................1189 PROTOCOLS/TRANSGENE/INTESTINE.......................................................................................................................................... 10 PROTOPORPHYRIA/IRON/CHELATORS.................................................................................................................................... 1102 S39 511904 0262 PROXIMAL TUBULE/TRANSPORT/ORGANIC CATIONS...................................................................................................... ,6l PROXIMAL TUBULE/ISOLATED PERFUSED TUBULE/BASOLATERAL HG TRANSPORT............................................ 99fi PROXIMAL TUBULE CELLS/CISPLATIN NEPHROTOXICITY/RENAL CORTICAL SLICES .......................................... ", gJ PSEUDO-EPIDERMIS/WATER PERMEATION BARRIER/BIS-(2-CHLOROETHYL) SULFIDE ........................................ 34J PSEUDOMONAS/IN VITRO TOX3COLOGY/RICIN................................................................................................................... ... PUBLIC HEALTH ASSESSMENT/TRAINING/ENVIRONMENTAL........................................................................................ 2gg PULMONARY/DUSTS/IN VITRO ASSAYS................................................................................................................................ "147 PULMONARY/OXIDANT INJURY/EPITHELIAL BARRIER ................................................................................. ,229 PULMONARY/PATHOLOGY/IMMUNIZATION ..................................................................................................................... I669 PULMONARY ABSORPTION/NITROGEN DIOXIDE/GLUTATHIONE .................................................................................... g PULMONARY ALVEOLAR MACROPHAGE/METABOLISM/BAP-COATED PARTICLE...................................................... 3,5 PULMONARY ALVEOLAR MACROPHAGE/DNA BINDING/METABOUSM OF BAP-COATED PARTICLE.................... 'i3,6 PULMONARY CLEARANCE/PULMONARY INFLAMMATION PARTICLES/OVERLOAD................................................. 279 PULMONARY EDEMA/PHOSGENE/LUNG INJURY..................................................................................................................|200 PULMONARY ENDOTHELIUM/GLUTATHIONE ADDUCT/ACROLEIN ................................................................................ . PULMONARY FIBROSIS/AMIODARONE/PULMONARY INFLAMMATION...........................................................................272 PULMONARY INFLAMMATION/PULMONARY FIBROSIS/AMIODARONE...........................................................................272 PULMONARY INFLAMMATION/SILICA/ACUTE TOXICITY................................................................................................... . PULMONARY INFLAMMATION PARTICLES/OVERLOAD/PULMONARY CLEARANCE....................... 279 PULMONARY INJURY/ALKALINE PHOSPHATASE/TYPE IICELLS....................................................................................... PULMONARY IRRITATION/METALWORKING FLUID/SENSORY IRRITATION.................................................................... PULMONARY SPECIFIC/CLONING/CYTOCHROME P-450 ......................................................................................................104 PULMONARY SPECIFIC/CLONING/CYTOCHROME P-450 ..................................................................................................... 497 PULMONARY SURFACTANT/CIGARETTE SMOKE/INHALATION EXPOSURE................................................................. 1679 PULMONARY TOXICITY/ACROLEIN/AEROSOL PARTICLE ................................................................................................ 1196 PULMONARY TOXICITY/POLYALKYLENE GLYCOL (PAG)/EXPOSURE ASSESSMENT.................................................. 1673 PURINERGIC RECEPTORS/ATP/CALCIUM............................................................................................................................... 1492 PYRENE/TOXICOKINETICS/PBPK MODEL..................................................................................................................................75 PYRETHROID INSECTICIDES/DYE-TRANSFER ASSAY/GAP JUNCTIONS .......................................................................... 689 PYRETHROID INSECTICIDES/POTASSIUM CHANNELS/PRIMARY NEURONAL CELL CULTURE ................................ 1539 PYRIDINE/RENAL INDUCTION/CYTOCHROME P-450 2E1 ......................................................................................................198 PYRIDOSTIGMINE/ORGANOPHOSPHORUS/PRETREATMENT............................................................................................ 1536 PYRIMETHAMINE/IMMUNE FUNCTION/HOST-RESISTANCE............................................................................................... 409 PYRIMETHAMINE/ZIDOVUDINE/AZT........................................................................................................................................ 529 PYRROLE/HAIR/2,5-HEXANEDIONE........................................................................................................................................ 1414 PYRROLES/BIOMARKERS/HEMOGLOBIN ADDUCTS..................................... 1415 PYRROLIZIDINE ALKALOID/JACOBINE/CARBOXYLESTERASE........................................................................................ 1299 PYRRROLIZIDINE ALKALOIDS/CARCINOGENICITY/HEPATOTOXiaTY.......................................................................... 567 Q-T INTERVAL/CARDIAC TOXICITY/ELECTROCARDIOGRAPHY...................................................................................... 1478 QEEG/XYLAZINE/CANINE.......................................................................................................................................................... 1376 QSAR/CARCINOGENICITY/NCI/NTP BIOASSAYS .................................................................................................................. 474 QUANTITATION/BROMODEOXYURIDEINE/S-PHASE............................................................................................................1106 QUATERNARIES/SUBCHRONIC TOXICITY/TERATOLOGY................................................................................................... 556 QUERCETIN/MECHANISMS OF DNA DAMAGE/GENOTOXITY..............................................................................................841 QUINOLINE/8-HYDROXYQUINOLINE/GLUTATHIONE........................................................................................................... 702 QUINOLINIC ACID/COPPER/NEUROTOXICITY....................................................................................................................... 1129 QUINONEMETHIDE/ORTHO-QUINONE/PHENOLS .................................................................................................................359 QUINONEMETHIDE/ALKYLPHENOL/HEPATOTOXiaTY..................................................................................................... 363 QUINONE METHIDES/PROTEIN ADDUCTS/ELECTROSPRAY MASS SPECTROMETRY .................................................. 1696 QUINONEOXIDO REDUCTAS E/ENDOTHELIUM/DT-DIAPHORASE.....................................................................................1476 QUINONE-THIOETHERS/COVALENTBINDING/NEPHROTOXICITY .................................................................................... 652 QUINONES/RENAL TRANSPORT/NEPHROTOXICITY..............................................................................................................'93 QUINONES/CALCIUM/MITOCHONDRIA.................................................................................................................................... 614 R-134A/BEHAVIORAL MEASURES/OZONE DEPLETING SUBSTANCE REPLACEMENT....................................................296 RAB BIT/FUMONIS IN/KIDNEY...................................................................................................................................................... 775 540 511904 0263 RABBIT/PRIMARY CULTURED HEPATOCYTES/GLUTATHIONE S-TRANSFERASE ......................................................... 1314 RABBIT PAPILLARY MUSCLE/R1CIN/BAY K 8644 ................................................................................................................... 1487 RADIATION/SURFACTANT PROTEIN C/TYPE IIPNEUMOCYTE .......................................................................................... .146 RADIATION/INTERLEUKIN-1/GENE EXPRESSION...................................................................................................................452a RADIATION/ATAXIA TELANGIECTASIA/REPRODUCTION..................................................................................................... 844 RADIATION/APOPTOSIS/LUNG .................................................................................................................................................1421 RADICALS/ALCOHOL/LIVER TRANSPLANTATION .................................................................................................................628 RADIOTELEMETRY/CARDIOVASCULAR/MONKEYS............................................................................................................. 1480 RADON-PROGENY/MICRONUCLEUS/LUNG FIBROBLASTS..................................................................................................1275 RAINBOW TROUT/EMBRYO/CYP2K1 .......................................................................................................................................... 105 RAINBOW TROUT/HORMONES/CYTOCHROME P-450 ............................................................................................................. 127 RAINBOW TROUT/GROWTH HORMONE/CYTOCHROME P-450 ..............................................................................................128 RAS-ONCOGENE/OKADAIC ACID/APOPTOSIS...........................................................................................................................167 RAT CYP1A1/NEGATTVE REGULATORY ELELMENT/PHOSPHOROTHIOATE OLIGONUCLEOTIDE................................125 RAT HEPATOCYTES/CYTOCHROME P-450 INDUCTION/XENOIOTICS..................................................................................708 RAT LIVER SLICES/P-45Q/METABOUC ACTIVATION.................................................................................................................25 RAT LIVER SLICES/CYTOCHROME P-450/METABOLISM .........................................................................................................28 RAT LONGEVITY/DIETARY PROTEIN/FC AND FEEDER DESIGN..........................................................................................1179 RAT LYMPH NODE CELLS/POLYCLONAL ANTIBODY RESPONSE/2-METHOXYETHANOL......................... 1396 RAT LYMPHOCYTE RESPONSE/HEAVY METALS/METAL INTERACTIONS ........................................................................419 RAT SMALL INTESTINE/GLUCOSE/CYSTEINE REGULATION ...............................................................................................644 RAT SPERM MORPHOMETRY/AUTOMATED IMAGE ANALYSIS/REPRODUCTIVE TOXICANTS..................................... 205 RAT STRAIN COMPARISON/CARBON TETRACHLORTOE/HEPATOTOXICITY ...................................................................1460 RAT SURVIVAL/CARCINOGENESIS/DIETARY RESTRICTION ............................................................................................... 933 RATS/INTRATRACHEAL/PARTICLES.......................................................................................................................................... 154 RATS/INHALATION/CHLOROFORM ............................................................................................................................................ 178 RATS/ACOUSTIC STARTLE/BEHAVIOR......................................................................................................................................301 RATS/CELLULAR PROLIFERATION/P34CDC2 KINASE.............................................................................................................422 RATS/REPRODUCTION/INTERLEUKIN-1 RECEPTOR ANTAGONIST..................................................................................... 575 RATS/GENTAMICIN/HISTOPATHOLOGY....................................................................................................................................814 RATS/BODYWEIGHT/INFUSION................................................................................................................................................... 860 RATS/TERATOLOGY/INFUSION................................................................................................................................................... 861 RATS/BLEEDING/JUGULAR VEIN ............................................................................................................................................... 862 RATS/NEUROTOXICITY/PERMETHRIN ..................................................................................................................................... 921 RATS/NEUROTOXICITY/PERMETHRIN ..................................................................................................................................... 922 RATS/PHARMACOKINETICS/POLYCHLORINATED BIPHENYLS..........................................................................................1059 RATS/NEUROTOXIC ESTERASE/OPIDN............................................ 1356 RATS/DEET/PHARMACOKINETICS............................................................................................................................................ 1717 RD50/SAR/RESPIRATORY IRRITATION .................................................................................................................................... 1204 REACTIVATION/ACETYLCHOUNESTERASE/INHIBrnON..................................................................................................... 904 REACTIVE ABSORPTION/SURFACE LINING LAYER/OZONE ................................................................................................1228 REACTIVE EPOXIDES/4-VINYLCYCLOHEXENE/OVOTOXICrTY........................................................................................... 212 REACTIVE INTEMEDIATE/COVALENT BINDING/HEPATOTOXICITY .................................................................................. 358 REACTIVE INTERMEDIATES/CYSTEINE S-CONJUGATES/FLUOROALKENES.....................................................................360 REACTIVE OXYGEN/HYDROQUINONE/COPPER...................................................................................................................... 597 REACTIVE OXYGEN/HYDROQUINONE/SUPEROXIDE DISMUTASE......................................................................................598 REACTIVE OXYGEN SPECIES/COCHLEA/HAIR CELL...............................................................................................................329 REACTIVE-METABOLITE/ACYL GLUCURONIDE/HEPATOTOXICITY .................................................................................. 715 REACTTVITY/TOLUENE DIISOCYANATE (TDiyiSOLATED, PERFUSED LUNG................................................................... 1239 RECEPTOR FUNCTION/RETINA/FENTHION .............................................................................................................................. 980 RECEPTORS/INVERTEBRATE/DIOXIN...................................................................................................................................... 1027 RECEPTORS/RETTNOIDS/CHEMOPREVENTION.......................................................................................................................1392 RECEPTORS/CELL PROLIFERATION/TCDD.............................................................................................................................. 1625 RECLAMATION/DIOXIN/SLUDGE..............................................................................................................................................1642 RECOMBINANT/BIOTECHNOLOGY/BLOOD PRODUCT.............................................................................................................24 541 511904 0264 RECOVERY/BORIC ACID/TESTIS............................................................................................................................................. 27Q RECOVERY/CALCIUM AND PH/CORNEAL EPITHELIUM.............................................................................................. "' 9g3 RECREATIONAL EXPOSURES/EXPOSURE SURVEY/RISK ASSESSMENT .................................................................. ' '' 550 RECRUITMENT/HIGH SCHOOL/EDUCATION ........................................................................................................................ 282 REDOX/ARSENIC/GLUTATHIONE.............................................................................................................................................. 0,4 REDOX CYCLING/DICHLOROFLUOROSCEIN/TOXICODYNAMICS..................................................................................... 625 REDUCTION/CYTOCHROME P-450/MICROSOMES ....................................................................................................................^ REFERENCE CONCENTRATION/BENCHMARK DOSE METHOD/CHROMIUM.................................................................... 59 REFERENCE CONCENTRATION/RESPIRATORY/ISOCYANATES....................................................................................... I594 REFERENCE DOSE/CHLORINATED COMPOUNDS/UNCERTAINTY FACTORS ................................................................ 159! REFERENCE DOSE/PCBS/RISK ASSESSMENT.......................................................................................................................... I593 REFLEX MODIFICATION/BRAINSTEM AUDITORY EVOKED POTENTIAL,3'-IMINODffROPIONITRILE....................1363 REGENERATION/NEUROTOXICrTY/NEURONALINJURY......................................................................................................... . REGENERATION/NEURITES/SCHWANN CELLS......................................................................................................................... ... REGENERATION/NEUROTROPHIC FACTORS/NEUROTROPHINS ............................................................................................ . REGENERATION/METALS/HORMESIS......................................................................................................................................1436 REGULATION/CYTOCHROME P-450 2E 1/OLIGONUCLEOTIDES.................................................................. ..........................124 REGULATORY/MOTOR ACTTVITY/NEUROTOXICITY ............................................................................................................ 295 REGULATORY/ADVERSE EFFECTS/PESTICIDES......................................................................................................................795 REGULATORY/DATABASE/PHARMACEUTICALS................................ 797 REGULATORY/RESINS/SENSITIZATION .................................................................................................................................. 1265 REGULATORY TOXICOLOGY/IMMUNOSUPPRESSION/RISK ASSESSMENT......................................................................... 23 RELEASE/CADMIUM/DOPAMINE ..............................................................................................................................................1120 REMEDIATION/RISK ASSESSMENT/DEGRADATION RATE ...................................................................................................548 RENAL ACTIVITY/GALLIUM ARSENIDE/INDIUM ARSENIDE ............................................................................................. 1018 RENAL CORTICAL SUCES/PROXIMAL TUBULE CELLS/CISPLAHN NEPHROTOXICITY .................................................183 RENAL DYSFUNCTION/DIETARY SUPPLEMENTS/GERMANIUM TOXICITY ......................................................................565 RENAL FUNCnON/NEPHROTOXICITY/SUCCINIMIDE.............................................................................................................177 RENAL GSH AND HG TRANSPORT/RENAL HG ACCUMULATION/MERCURY-GLUTATHIONE.......................................997 RENAL HG ACCUMULATION/MERCURY-GLUTATHIONE/RENAL GSH AND HG TRANSPORT.......................................997 RENAL INDUCTION/CYTOCHROME P-450 2EI/PYREDINE....................................................................................................... 198 RENAL INJURY CATTLE/APLASTIC ANAEMIA/TOXIC CYSTEINE CONJUGATES...............................................................194 RENAL PAPILLARY NECROSIS/CARCINOGENICITY/NONSTEROIDAL ANTIINFLAMMATORY DRUG......................... 166 RENAL PROXIMAL TUBULE/CELL INJURY/CELL REGENERATION......................................................................................160 RENAL PROXIMAL TUBULE/CELLULAR TOX3CITY/M-BROMOPHENYL CYSTEINE.........................................................162 RENAL PROXIMAL TUBULE/CYTOTOXICITY/PHENYL-2-HYDROXYETHYL CYSTEINE ................................................. 163 RENAL PROXIMAL TUBULE/CELL INJURY AND DEATH/EXTRACELLULAR ACIDOSIS...................................................189 RENAL PROXIMAL TUBULE/GLYCINE RECEPTOR/CELL DEATH..........................................................................................190 RENAL PROXIMAL TUBULE/CELL DEATH/CYTOPROTECTION ........................................................................................... 930 RENAL PROXIMAL TUBULES/CYCLOSPORIN A/PROOXIDANTS ......................................................................................... 613 RENAL TRANSPORT/ANTINEOPLASTIC DRUGS/VINCA ALKALOIDS.................................................................................. 186 RENAL TRANSPORT/NEPHROTOX3CITY/QUINONES ............................................................................................................... 193 RENAL TRANSSPORT/HEAT SHOCK/CHEMICAL STRESS..................................................................................................... 1135 REPAIR/LOW DOSE....................................................................................................................................................................... 1428 REPELLENT/ACUTE/MUTAGENICITY ....................................................................................................................................... 923 REPELLENT/TERATOLOGY/REPRODUCnVETOXICITY........................................................................................................ 925 REPELLENT/AQUATIC/AVIAN..................................................................................................................................................... 926 REPERFUSION INJURY/LIPID PEROXIDATION/KUPFFER CELLS........................................................................................... 626 REPRESSION/OVARIAN CELLS/TCDD ...................................................................................................................................... 1615 REPRESSOR/CYP1A1 /GENE REGULATION ................................................................................................................................493 REPRODUCTION/FERTILIZATION/3,3\4,4,-TETRACHLOROBIPHENYL ..............................................................................223 REPRODUCTION/ESTROGEN RECEPTOR/ORGANOCHLORINE............................................................................................. 227 REPRODUCTION/NEUROTOXICITY/TRINITROBENZENE....................................................................................................... 574 REPRODUCTION/INTERLEUKIN-1 RECEPTOR ANTAGONIST/RATS......................................................................................575 REPRODUCTION/AXIOLYTTC/SEROTININ.................................................................................................................................. 576 542 511004 0265 REPRODUCTION/4-VINYL-1 -CYCLOHEXENEDIEPOXIDE/GLUTATHIONE .......................................................................... REPRODUCTTON/RADIATTON/ATAXIA TELANGIECTASIA.................................................................................................... . REPRODUCTTVE/TOXICOLOGY/FEMALE ..................................................................................................................................224 REPRODUCTIVE ALTERATIONS/TCDD/SEX DIFFERENTIATION..........................................................................................1502 REPRODUCTIVE EFFECTS/HAZARD RANKING/OSHA............................................................................................................ 793 REPRODUCTIVE PERFORMANCE/INTRAVENOUS INFUSION/TEMPERATURE .................................................................. 221 REPRODUCTIVE SYSTEM/OOCYTE DESTRUCTION/FOLLICULAR DEVELOPMENT .........................................................213 REPRODUCTIVE TOXICANTS/RAT SPERM MORPHOMETRY/AUTOMATED IMAGE ANALYSIS..................................... 205 REPRODUCTIVE TOXICITY/DISRUPTED PUBERTAL GROWTH/LEAD..................................................................................256 REPRODUCTIVE TOXICITY/DEVELOPMENTAL TOXICITY/PHOTOVOLTAIC MATERIALS ............................................. 581 REPRODUCTIVE TOXICITY/REPELLENT/TERATOLOGY........................................................................................................ 925 REPRODUCTIVE TOXICITY/DEVELOPMENTAL TOXICITY/PHOTOVOLTAIC METALS................................................... 1020 RESINSmiERMAL EMISSIONS/SENSORY IRRITATION...........................................................................................................972 RESINS/SENSITIZATION/REGULATORY .................................................................................................................................. 1265 RESISTANCE/STYRENE/CELL PROLIFERATION ...................................................................................................................... 685 RESISTANCE/MULTIDRUG RESISTANCE (MDRyPESTICIDES/INSECTICIDES ...................................................................1543 RESOURCE/HUMAN/TISSUE....................................................................................................................................................... 1138 RESPIRATORY/ISOCYANATES/REFERENCE CONCENTRATION..........................................................................................1594 RESPIRATORY/HYPERSENSmVITY/IGE.................................................................................................................................. 1610 RESPIRATORY/BRONCHOVEOLAR LAVAGE/BIOLOGICAL MARKERS........................................................... 1663 RESPIRATORY IRRITATION/RD50/SAR .................................................................................................................................... 1204 RESPIROMETER/PROPAGULE/COLONY FORMING UNITS (CFU'S)...................................................................................... 1629 RESPONSE SURFACE METHODOLOGY/STRUCTURE ACTIVITY RELATIONSHIPS/ POLYCHLORINATED BIPHENY1 ............................................................................................................................................. 538 RESTRAINT-INDUCED STRESS/CARPET EMISSIONS TESTING/NEUROTOXICITY EVALUATION ................................. 967 RETENTION/FIBER/LUNG ............................................................................................................................................................. 141 RETINA/METHANOL/FOLATE.......................................................................................................................................................979 RETINA/FENTHION/RECEPTOR FUNCTION ..............................................................................................................................980 RETINA/PHOSPHODIESTERASE/LEAD...................................................................................................................................... U21 RETINA/LEAD/SODIUM-POTASSIUM ATPASE........................................................................................................................ 1122 RETINA/APOPTOSIS/LEAD ......................................................................................................................................................... 1123 RETINAL PIGMENT EPITHELIUM/CYNOMOLGUS/ERG C-WAVE MEASUREMENT .......................................................... 976 RETINOBLASTOMA GENE/TRANSFORMATION/NICKEL...................................................................................................... .523 RETINOIC ACID/SKIN CARCINOGENESIS/MALIGNANT CONVERSION................................................................................671 RETINOIC ACID RECEPTOR/RETINOID/LIMB CULTURE.........................................................................................................593 RETINOID/LIMB CULTURE/RETINOIC ACID RECEPTOR.........................................................................................................593 RETTNOIDS/CHEMOPREVENTION/RECEPTORS.......................................................................................................................1392 RETINOL/LIVER/CCU................................................................................................................................................................... 1468 RHODAMINE 123/LASER CYTOMETRY/MITOCHONDRIA.......................................................................................................319 RICIN/INHALATION/AEROSOL/TOXICITY.................................................................................................................................. 145 RICIN/VACCINATION/LUNG......................................................................................................................................................... 779 RICIN/VACCINE/IMMUNIZATION............................................................................................................................................... 780 RICIN/OXIDATTVE STRESS/TUMOR NECROSIS FACTOR......................................................................................................... 781 RICIN/PSEUDOMONAS/IN VITRO TOXICOLOGY...................................................................................................................... 782 RICIN/BAY K 8644/RABBIT PAPILLARY MUSCLE...................................................................................................................1487 RISK/CHLORAMBEN/CANCER..................................................................................................................................................... 539 RISK/ACETAMIDE/CANCER ......................................................................................................................................................... 541 RISK/EXPOSURE/HAZARD........................................................................................................................................................... 1146 RISK/ASSESSMENT/NONCANCER.............................................................................................................................................. 1592 RISK ASSESSMENT/REGULATORY TOXICOLOGY/IMMUNOSUPPRESSION.......................................................................... 23 RISK ASSESSMENT/ARSENIC/CARCINOGENICITY.................................................................................................................... 51 RISK ASSESSMENT/ARSENIC/EPA GUIDELINES ........................................................................................................................ 52 RISK ASSESSMENT/EXPOSURE MODELING/BLOOD LEAD ..................................................................................................... 53 RISK ASSESSMENT/LEAD/PHARMACOKINETIC MODELS .......................................................................................................55 RISK ASSESSMENT/LEAD/TOXICOKINETIC MODELS ...............................................................................................................56 543 511904 0266 RISK ASSESSMENT/BLOOD LEAD/PREDICTTVE MODELS.......................................................................................... RISKASSESSMENT/METALS/METHYLMERCURY.................................................................................................... 60 RISK ASSESSMENT/CADMIUM/TOXICOKINEnCS ..........................................................................................................- 62 RISK ASSESSMENT/METALS/TRANSFORMATTON ................................................................................................................... 6} RISKASSESSMENT/ROUTE-TO-ROUTE EXTRAPOLATION/METALS ............................................................................. RISKASSESSMENT/2-METHOXYETHANOL/PBPK MODELING ........................................................................................ 88 RISK ASSESSMENT/NASAL TOXICITY/UPPER RESPIRATORY TRACT ........................................................................... I55 RISK ASSESSMENT/ENVIRONMENT/EDUCATION ............................................................................................................... ^290 RISK ASSESSMENT/SKIN PERMEABILITY/IN VITRO METHODOLOGY............................................................................... 342 RIS K ASSESSMENT/TCDD/HAHS............................................................................................................................................. '41I RISK ASSESSMENT/HAZARD IDENTIHCATION/IMMUNOTOXiaTY.................................................................................. . RISK ASSESSMENT/IMMUNOTOXICOLOGY/CYCLOSPORIN A............................................................................................ . RISK ASSESSMENT/CELL PROLIFERATION/NASAL CARCINOGENESIS............................................................................. 536 RISK ASSESSMENT/POLYCYCLIC AROMATIC HYDROCARBONS/POLYCYLIC ORGANIC MATTER.............................537 RISK ASSESSMENT/CARCINOGENICITY/METHYL TERTIARY BUTYL ETHER ..................................................................540 RISK ASSESSMENT/DATA QUALITY OBJECTIVES/RISK BASED CRITERIA....................................................................... 544 RISK ASSESSMENT/EXPOSURE ASSESSMENT/CONTAMINANT TRANSPORT................................................................... 546 RISK ASSESSMENT/VOLATILE ORGANIC COMPOUNDS/INHALATION....................................................... 547 RISK ASSESSMENT/DEGRADATION RATE/REMEDIATION .................................................................................................. 548 RISK ASSESSMENT/CYANIDES/MANUFACTURED GAS PLANTS .........................................................................................549 RISK ASSESSMENT/RECREATIONAL EXPOSURES/EXPOSURE SURVEY ............................................................................550 RISK ASSESSMENT/EXPOSURE ASSESSMENT/METALS........................................................................................................ 553 RISK ASSESSMENT/POTABLE WATER/ACETONE....................................................................................................................554 RISK ASSESSMENT/DRUG DEVELOPMENT/MUTAGENIC ASSESSMENT ........................................................................... 558 RISK ASSESSMENT/ENDOSULFAN/LOW NOEL........................................................................................................................801 RISK ASSESSMENT/CALORIC RESTRICTION/TOXICITY STUDIES ....................................................................................... 934 RISK ASSESSMENT/DOSIMETRY/MODELING ........................................................................................................................ [142 RISK ASSESSMENT/MACHINE LEARNING/DEVELOPMENTAL TOXICOLOGY ................................................................ 1145 RISK ASSESSMENT/HAZARD SCREENING/OCCUPATIONAL EXPOSURE..........................................................................1150 RISK ASSESSMENT/SAFETY ANALYSIS/CONCENTRATION - LIMIT GUIDELINES...........................................................1151 RISK ASSESSMENT/2-METHYL-4,5-TRIMETH.-4-ISOTH.-3-ONE/SKIN SENSITIZATION................................................... 1263 RISK ASSESSMENT/U-SHAPED/DOSE-RESPONSE.................................................................................................................. 1427 RISK ASSESSMENT/SOLVENTS/BEHAVIOR ............................................................................................................................ 1430 RISK ASSESSMENT/MOTOR ACTTVITY/SOLVENTS .............................................................................................................. 1431 RISK ASSESSMENT/TISSUE REPAIR/DOSE-RESPONSE .........................................................................................................1432 RISK ASSESSMENT/DOSE-RESPONSE/TCDD .......................................................................................................................... 1516 RISKASSESSMENT/DOSE-RESPONSE/TCDD .......................................................................................................................... 1517 RIS K ASSESSMENT/PESTICIDES/TOXIC EQUIVALENCY FACTORS....................................................................................1540 RISKASSESSMENT/DEXAMETHASONE/IMMUNOTOXICITY............................................................................................... 1583 RISK ASSESSMENT/ACRYLAMIDE/EXTRAPOLATION...........................................................................................................1586 RISK ASSESSMENT/REFERENCE DOSE/PCBS.......................................................................................................................... 1593 RISK ASSESSMENT/ENVIRONMENTAL.................................................................................................................................... 1641 RISK BASED CRITERIA/RISK ASSESSMENT/DATA QUALITY OBJECTIVES........................................................................ 544 RNA/OXIDATTVE DAMAGEDYES...............................................................................................................................................623 RNA POLYMERASE n/NUCLEAR TYROSINE KINASES/PHOSPHORYLATION ...................................................................1418 RODENT/SURVIVAL/CARCINOGENICITY................................................................................................................................ 1177 RODENT/NEUROTOXICITY SCREENING BATTERY/PESTICIDES ........................................................................................1538 RODENTS/HISTORICAL CONTROL DATA/NEUROTOXICITY SCREENING BATTERY .......................................... 1375 ROS 17/2.8/KINETICS/CADMIUM ................................................................................................................................................. 870 ROTENONE/TAXOL/CELL PROLIFERATION................................................................................................................... 39 ROUTE OF ADMINISTRATION/TESTICULAR TOXICITY/1,3-DINTFROBENEZENE METABOLISM................................... 265 ROUTE-TO-ROUTE EXTRAPOLATION/METALS/RISK ASSESSMENT......................................................................................64 RWJ-22164/TOCOLYTIC AGENT/GENERAL TOXICOLOGY .....................................................................................................832 S-BR-(DIGSYL)HO/HISTONE MRNA/GENE EXPRESSION.........................................................................................................653 S-METHYL N.N-DIETHYLTHIOL CARBAMATE/DISULFIRAM BIOACTIVATION/CYTOCHROME P-450 2A/3A..............495 511904 0267 S-PHASE/QUANTTTATION/BROMODEOXYURIDEINE............................................................................................................. 1106 SAFETY/AMYOTROPHIC LATERAL SCLEROSIS/INSULIN-LIKE GROWTH FACTOR .........................................................378 SAFETY ANALYSIS/CONCENTRATION - LIMIT GUIDELINES/RISK ASSESSMENT.......................................................... 1151 SAFETY ASSESSMENT/CONTINTJOUS INFUSION/DEVICES ............................................................................... ,...............1479 SAFETY GUIDELINES/PHARMACEUTICAL INERTS/EXCIPIENTS ......................................................................................... 796 SALICYLATE/MATERNAL REPRODUCTIVE/GESTATION....................................................................................................... 217 SALINE/INFUSION/MOUSE ................................................................................................................................. 865 SALIVA/BIOMARKERS/IGA............................................................................................................................................................. 13 SAR/RESPIRATORY IRRITATION/RD50 ........................................................................................................................... . . . .1204 SCHWANN CELLS/REGENERATION/NEURITES............................................................................................................................ 2 SCHWANN CELLS/NEUROGUAL CELLS/NEUROREGENERATION........................................................................................... 4 SCIDMOUSE/THYMUS/IMMUNOTOXICrrY.............................................................................................................................. 480 SCREEN/ANTIFIBROGENIC/ANTICIRRHOTIC/LIPOCYTE....................................................................................................... 313 SCREEN/AH RECEPTOR/AGONISTS............................................................................................................................................1614 SCREENING TEST/DRUSOPHILA BIOASSAY/DEVELOPMENTAL TOXICITY ...................................................................... 594 SCREENING TOOL/DOSE RECONSTRUCTION/CHEMICALS/RADIONUCLIDES ................................................................. 1148 SEAFOOD CONSUMPTION/FLORIDA/EXPOSURE ASSESSMENT........................................................................................... 563 SEB/INHALATION/AEROSOL/TOXICITY ................................................................................................................................. 1671 SECALONIC ACID D/BINDING/CLAY ......................................................................................................................................... 790 SECOND MESSENGERS/CYTOCHROME P-45Q/HEPATOCYTES .......................................................................... 113 SECOND MESSENGERS/OXIDANT TUMOR PROMOTERS/SK1N CELLS .............................................................................. 1496 SECRETION/2,5-HEXANEDIONE/SERTOLI CELLS .................................................................................................................... 263 SEDIMENT/AMES ASSAY/MUTATOX........................................................................................................................................ 1634 SEDIMENTS/PAHS/GENOTOXICITY ..........................................................................................................................................1656 SEIZURES-LINDANE/GENE EXPRESSION/NUCLEAR RECEPTORS ..................................................................................... 448 SELENITE/GLUTATHIONE/ACTIVEOXYGEN.......................................................................................................................... 1008 SELENIUM/METALLOTHIONEIN/CADMIUM.............................................................................................................................. 875 SELENIUM/ACTIVEOXYGEN/DNA STRAND BREAKS........................................................................................................... 1009 SELENIUM/SELENOPROTEIN/KINETICS .................................................................................................................................. 1010 SELENIUM METABOLISM/FLAVIN-CONTAINING MONOOXYGENASE/DIMETHYLSELENIDE....................................... 371 SELENOPROTEIN/KINETICS/SELENIUM .................................................................................................................................. 1010 SEMEN/HISTOPATHOLOGY/TESTES........................................................................................................................................... 206 SEMEN/TESTES/HISTOPATHOLOGY........................................................................................................................................... 266 SENSITIVITY/ACETYLCHOLINESTERASE/ERYTHROCYTE................................................................................................. 1564 SENSITIVITY ANALYSIS/PHARMACOKINETICS/TOXICOKINETICS/CARBONTETRACHLORIDE ....................................74 SENSITIZATION/STRUCTURE-ACTIVITY/MULTICASE ......................................................................................................... 1264 SENSITIZATION/REGULATORY/RESINS ..................................................................................................................................1265 SENSITIZATION/ADDUCTS/TOLUENE DIISOCYANATE......................................................................................................... 1409 SENSITIZATION/MURINE MODEL/TOLUENE DIISOCYANATE ............................................................................................1607 SENSITIZATION TEST/CONTACT DERMATITIS/MAXIMIZATION TEST.............................................................................. 1266 SENSORY IRRITATION/LOW LEVEL VOC EXPOSURE/INDOOR AIR..................................................................................... 968 SENSORY IRRITATION/ASTM E981/CARPETS............................................................................................................................969 SENSORY IRRITATION/NEUROTOXICITY/CARPETS ...............................................................................................................970 SENSORY IRRITATION/RESINS/THERMAL EMISSIONS...........................................................................................................972 SENSORY IRRITATION/PULMONARY IRRITATION/METALWORKING FLUID................................................................... 1203 SENSORY IRRITATION/INHALATION/THERMAL EMISSIONS ..............................................................................................1205 SENSORY IRRITATION/INHALATION/THERMAL EMISSIONS ..............................................................................................1206 SENSORY IRRITATION/TRIETHYLENE GLYCOL/AEROSOL..................................................................................................1207 SENSORY IRRITATION/HYPERSENSmVTTY/GLUTARALDEHYDE...................................................................................... 1208 SEQUENCING/DNA ADDUCTS/PCR............................................................................................................................................. 858 SEROTININ/REPRODUCTION/AXIOLYTIC..................................................................................................................................576 SEROTONIN/LEAD/BRAIN........................................................................................................................................................... 1126 SERTOLI CELLS/SECRETION/2,5-HEXANEDIONE .................................................................................................................... 263 SERUM FACTOR/COCAINE/IMMUNOSUPPRESSION............................................................................................................... 1240 SEVOFLURANE/METABOLISM/LTVER........................................................................................................................................691 545 511904 0268 SEVOFLURANE/BIOTRANSFORMATION/NEONATES.................................................................................................... SEX DIFFERENCE/TCDD/CYTOCHROME P-450 ........................................................................................................ - '' 1504 SEX DIFFERENCES/HEPATIC CYTOLETHALITY/PKC INHIBITOR...................................................................................... 322 SEX DIFFERENTIATION/REPRODUCnVE ALTERATIONS/TCDD....................................................................................... , 5Q2 SEX HORMONES/IGA NEPHROPATHY/VOMITOXIN.......................................................................................................... 1247 SEX-RELATED DIFFERENCES/BUTADIENE/CYTOCHROME P-450 ............................................................................... ' 10l SEXUAL DIFFERENTIATION/BRAIN NUCLEI/TCDD ......................................................................................................... " '73, SEXUAL DIMORPHISM/COVALENT BINDING/DRUG METABOLISM ............................................................................... ' 93 SH-SY5Y HUMAN NEUROBLASTOMA CELLS/ACETYLCHOLINESTERASE/NEUROPATHY TARGET ESTERASE .... '313 SHEEP/NITROGEN DIOXIDE/NASAL TOXICITY.................................................................................................................... ,225 SHEEP RED BLOOD CELLS/HUMORAL IMMUNITY/HAZARD IDENTIFICATION............................................................... . SIGNAL PROCESSING/STARTLE RESPONSE/BEHAVIOR........................................................................................................ SIGNALLING/IMMUNOSUPPRESSION/CALCIUM..................................................................................................................... . SILICA/IN VTTRO/DLATOMS........................................................................................................................................................... SILICA/MAP KINASE/MACROPHAGES.......................................................................................................................................240 SILICA/NEUTROPHILS/ADHESION MOLECULES..................................................................................................................... 241 SILICA/ACUTE TOXICITY/PULMONARY INFLAMMATION.................................................................................................... 277 SILICA/MUTATION/INFLAMMATION.........................................................................................................................................278 SILICA/CYTOKINES/INFLAMMATION .......................................................................................................................... SILICON CARBIDE WHISKERS/MESOTHELIOMA/FIBERS/PARTICLES .............................................................................1664 SILICON DIOXIDE/NTTRIC OXIDE/TYPE II CELLS ................................................................................................................... 745 SILICONE/MAMMARY IMPLANT/CARCINOGENICITY BIOASSAY.......................................................................................835 SILICONE/NATURAL KILLER CELLS/IMMUNOTOXICOLOGY............................................................................................. 1250 SILICONE/DISPOSITION/DERMAL ABSORPTION.................................................................................................................... 1720 SILICONES/ADJUVANCY/HYPERSENSITIVITY ......................................................................................................................... 20 SILOXANE/INHALATION/DEVELOPMENTAL............................................................................................................................572 SIMULATION/FOCAL GROWTH/CARCINOGENESIS ...............................................................................................................1144 SINGLE CELL GEL/IN VIVO TOXICOLOGY/DNA DAMAGE........................................................................................................9 SINUSOIDAL CELLS/LIVER TRANSPLANTATION/ELECTRON MICROSCOPY .................................................................. 1089 SISTER CHROMATID EXCHANGES/STYRENE OXIDE/HUMAN LYMPHOCYTES................................................................843 SIZE-SELECTED/CHRYSOTILE/ASBESTOS FIBERS.................................................................................................................. 152 SKIN/CYTOCHROME P-450/IN VITRO......................................................................................................................................... 337 SKIN/ABSORPTION/ARSENICALS ...............................................................................................................................................355 SKIN/IMMUNOMODULATTON/SOLVENTS................................................................................................................................. 412 SKIN/ULTRAVIOLET RADIATION/IMMUNOLOGY .................................................................................................................. 478 SKIN/CONTACT SENSITIZATION/HUMANS ..............................................................................................................................557 S KIN/ABSORPTION/CARBARYL...................................................................................................................................................664 SKIN/ERYTHEMA/SULFUR MUSTARD ....................................................................................................................................... 666 SKIN/NITRIC OXIDE/UVB.............................................................................................................................................................. 742 SKIN ABSORPTION/ETHYLENE OXIDE/KINETICS.................................................................................................................... 667 SKIN CANCER/PCR/P53.................................................................................................................................................................. 519 S KIN CARCINOGENESIS/MALIGNANT CONVERSION/RETINOIC ACID............................................................................... 671 SKIN CELLS/SECOND MESSENGERS/OXIDANT TUMOR PROMOTERS .............................................................................. 1496 SKIN IRRITATION/IN VITRO/ARACMDONIC ACID.................................................................................................................. 335 SKIN KERATINOCYTES/SURFACTANTS/CYTOTOXICITY.......................................................................................................354 SKIN MODEL/PERCUTANEOUS ABSORPTION/IN VITRO TOXICOLOGY..............................................................................349 SKIN PENETRATION/TOPICAL SKIN PROTECTANT/ACETYLCHOLINESTERASE.............................................................. 341 SKIN PERMEABILITY/IN VITRO METHODOLOGY/RISK ASSESSMENT................................................................................342 SKIN RESERVOIR/BIOAVAILABILITY/ABSORBED DOSE .......................................................................................................662 SKIN SENSITIZATION/RISK ASSESSMENT/2-METHYL-4,5-TRIMETH.-4-ISOTH.-3-ONE................................................... 1263 SKIN SENSmZATTON/TUMOR NECROSIS FACTOR/LANGERHANS CELLS .......................................................................1605 SKIN SENSITIZATION/CYTOKINES/LYMPH NODE CELLS ................................................................................................... 1606 SKIN TUMOR/LATENCY TTME/DOSE-RESPONSE...................................................................................................................... 465 SLUDGE/RECLAMATION/DIOXIN.............................................................................................................................................. 1642 SMALL INTESTTNE/CYTOCHROME P-45Q/INDUCERS...............................................................................................................491 751 546 511904 0269 SMALL INTESTTNE/BIOTRANSFORMATION/PHARMACOKINETICS....................................................................................1725 SMELTER EMISSIONS/LEAD/EXPOSURE......................................................................................................................................58 SMOKE/HISTOPATHOLOGY/D'IHALATION................................................................................................................................ 72! SMOKE, PASSIVE/LUNG TOXICITY/GENE EXPRESSION.......................................................................................................1680 SMOKELESS TOBACCO EXTRACT/VITAMIN E SUCCINATE/NITRIC OXIDE ...................................................................... 741 SMOKERS/HEMOGLOBIN/4-AMINOBIPHENYL .......................................................................................................................1472 SMOOTH MUSCLE CELLS/CELL PROLIFERATION/PROTEIN SECRETION............................................................................420 SMOOTH MUSCLE CELLS/PROTO-ONCOGENE/BENZO(A)PYRENE ..................................................................................... 511 SMOOTH MUSCLE CELLS/BENZO(A)PYRENE/C-HA-RAS ...................................................................................................... 512 SOD/ANTIOXIDANT GENE/ATX 1 ................................................................................................................................................. 441 SODIUM SAACHARIN/MALE/FEMALE/URINE .......................................................................................................................... 438 SODIUM-POTASSIUM ATPASE/RETINA/LEAD.........................................................................................................................1122 SOIL/PERCUTANEOUS ABSORPTION/2,4-D................................................................................................................................663 SOIL/TRICHLOROETHYLENE/DERMAL BIOAVAILABILITY...................................................................................................673 SOIL CONTAMINANTS/ORGANOPHOSPHATES/MniTARY SITES........................................................................................1635 SOLVENTS/TOXICOKINETICS/MIXTURES....................................................................................................................................69 SOLVENTS/TOXICOKINETICS/MIXTURES....................................................................................................................................72 SOLVENTS/TOXICOKINETICS/BIOTRANSFORMATION........................................................................................................... 380 SOLVENTS/S KIN/IMMUNOMODULATION..................................................................................................................................412 SOLVENTS/DEVELOPMENTALTOXICITY/NEUROTOXICITY................................................................................................. 583 SOLVENTS/BEHAVIOR/RISK ASSESSMENT ............................................................................................................................ 1430 SOLVENTS/RISK ASSESSMENT/MOTOR ACTIVITY ................... 1431 SOLVOLYTIC PRODUCTS/BUTADIENE/BUTADIENE MONOXIDE..........................................................................................367 SOMATOSENSORY FUNCTION/METHYLMERCURY/DEVELOPMENTAL EXPOSURE........................................................ 991 SPECffiS/IMMUNOSUPPRESSION/MAA....................................................................................................................................... 403 SPECIES COMPARISON/MACROPHAGES/IMMUNE SYSTEM ................................................................................................. 402 SPECIES COMPARISON/DICHLORVINYLCYSTEINE/TRICHLOROETHYLENE ...................................................................1085 SPECIES DIFFERENCE/DISPOSmON/2-[ 14c] ACRYLONITRITE ............................................................................................1719 SPECIES DIFFERENCES/4-VINYLCYCLOHEXENE/METABOLISM........................................................................................1312 SPERM/ACRYLAMIDE/GLUTATHIONE....................................................................................................................................... 203 SPERMATOGENESIS/FUNGICIDE/TESTES..................................................................................................................................267 SPERMATOGENESIS/IN UTERO AND LACTATIONAL/TCDD ............................................................................................... 1499 SPERMATOZOA/DNAADDUCTS/CISPLATIN ............................................................................................................................204 SPHINGOLIPID/CATFISH/FUMONISIN B1................................................................................................................................... 771 SPHINGOLIPID/LLC-PKi CELL/FUMONISIN ..............................................................................................................................772 SPHINGOLIPID METABOLISM/FUMONISIN/BIOMARKERS.....................................................................................................770 SPIN TRAPS/OZONE/OXIDATTVE DAMAGE............................................................................................................................... 636 SPIN TRAPS/OXIDATIVE DAMAGE/PARKINSON'S DISEASE ................................................................................................1336 SPINAL CORD/OPIDP/PERIPHERAL NERVE................................................................................................................................762 SPLEEN/DNA DAMAGE/DIMETHYLNITROSAMINE ............................................................................................................... 1280 SPLEEN/UNOLEIC ACID ANUJDE/IRON OVERLOAD............................................................................................................. 1557 SPRAGUE-DAWLEY RAT/BODYWEIGHT/SURVTVAL............................................................................................................. 1178 SPRAGUE-DAWLEY RATS/SURVIVAL RATES/COMPARISON STUDY ................................................................................ 1176 STABILITY/CYTOCHROME P-450/HUMAN ................................................................................................................................ 110 STAGEWISE DESIGN/STATISTICAL DESIGN/ANIMAL REDUCTION.................................................................................... 567a STARTLE RESPONSE/BEHAVIOR/SIGNAL PROCESSING....................................................................................................... 301a STATISTICAL DESIGN/ANIMAL REDUCTION/STAGEWISE DESIGN....................................................................................567a STEMCELL/HEMOPOIESIS/PROPANIL ......................................................................................................................................1558 STEROID/INDUCTION/SULFOTRANSFERASE.......................................................................................................................... 1328 STIMULATION/PHENCYLIDINE/NITRIC OXIDE SYNTHASE................................................................................................... 735 STOCHASTIC/MODEL/DOSE-RESPONSE .................................................................................................................................. 1143 STOCHASTIC MODELING/LEAD/CANCER POTENCY...............................................................................................................543 STOCHASTIC RISK ASSESSMENT/ARSENIC/PROBABILISTIC RISK ASSESSMENT.............................................................551 STOMACH PH/DIDEOXYINOSINE/BIOAVAILABILITY.............................................................................................................379 STRAIN A MICE/TUMORIGENIC/MANUFACTURED GAS PLANT RESIDUE.......................................................................... 470 547 511904 0270 STRAIN COMPARISONS/TRICHLOROETHYLENE/METABOLISM ........................................................................................ STRAIN DIFFERENCES/OZONE/INFLAMMATION .............................................................................................................. 274 STRESS/METABOLIC INHIBITION/CYTOCHROME P-450 ...................................................................................................... 1173 STRESS 70/STRESS PROTEINS/PROTEOTOXICITY.................................................................................................................. ]434 STRESS GENES/MOLECULAR ENDPOINT/GENE INDUCTION...............................................................................................452b STRESS PROTEINS/LIVER SLICES/IN VITRO............................................................................................................................... . STRESS PROTEINS/HEAT SHOCK PROTEINS/HEPATOTOXICITY .........................................................................................452 STRESS PROTEINS/CELL INJURY/OZONE ..................................................................................... 624 STRESS PROTEINS/HEAT SHOCK PROTEINS/GLUCOSE-REGULATED PROTEINS.............................................................1132 STRESS PROTEINS/MOLECULAR BIOMARKERS/ENVIRONMENTAL MONITORING ......................................................1! 33 STRESS PROTEINS/HEAT SHOCK PROTEINS/GENE INDUCTION........................................................................................... STRESS PROTEINS/MITOCHONDRIA/ADDUCTS ........................................................................................................................ STRESS PROTEINS/BIOMONITORING/AQUATIC .................................................................................................................... 1433 STRESS PROTEINS/PROTEOTOXICITY/STRESS 70.................................................................................................................. 1434 STRESS RESPONSE/TISSUE SPECIFICITY/IN VITRO................................................................................................................447 STROMAL CELLS/MITOCHONDRIA/BENZO(A)PYRENE ......................................................................................................1551 STRUCTURE ACTIVITY/POLYCYCLIC AROMATIC HYDROCARBONS/IMMUNOSUPPRESSION.....................................755 STRUCTURE ACTIVITY RELATIONSHIPS/POLYCHLORINATED BIPHENY 1/RESPONSE SURFACE METHODOLOGY .538 STRUCTURE ACTIVITY RELATIONSHIPS/ALKOXYSILANES/INHALATION............................................... 1215 STRUCTURE-ACTTVITY/MUTAGENICITY/PHENYLENEDIAMINE......................................................................................... 847 STRUCTURE-ACTIVITY/MULTICASE/SENSITIZATION ......................................................................................................... 1264 STRUCTURE-ACTIVITY/5H-PHORBOL ESTER BINDING/POLYCHLORINATED BIPHENYLS........................................... 1352 STRUCTURE-ACTTVITYRELATIONSHIP/GLUTATHIONE/ALDEHYDES............................................................................... 658 STRUCTURE-ACTIVITY RELATIONSHIP ANAL/AROMATIC AMINES/CARCINOGENIC HAZARD/ RISK ASSESSMENT .................................................................................................................................................................... 453 STRUCTURE-INDUCTION/CYP2B1/2/PCBS.................................................................................................................................. Ill STRUCTURE-INDUCTION/CYP2B1/2/PCBS.................................................................................................................................. 120 STYRENE/STYRENE OXIDE/TOXICOKINETICS ..........................................................................................................................80 STYRENE/1,3-BUTADIENE/MIXTURES ....................................................................................................................................... 87 STYRENE/STYRENE OXIDE/BIOAVAILABILITY ......................................................................................................................390 STYRENE/CELL PROLIFERATION/RESISTANCE ......................................................................................................................685 STYRENE/STYRENE OXIDE/METABOLISM.............................................................................................................................. 1288 STYRENE OXIDE/TOXICOKINETICS/STYRENE ..........................................................................................................................80 STYRENE OXTOE/BIOAVAILABILITY/STYRENE ...................................................................................................................... 390 STYRENE OXIDE/LABELING INDEX/FORESTOMACH ............................................................................................................ 428 STYRENE OXIDE/HUMAN LYMPHOCYTES/SISTER CHROMATID EXCHANGES................................................................ 843 STYRENE OXIDE/METABOLISM/STYRENE.............................................................................................................................. 1288 SUBCHRONIC/BENCHMARK DOSE/DOSE-RESPONSE ........................................................................................................... 1588 SUBCHRONIC TOXICITY/HSCHER RATS/1,3,5-TRINITROBENZENE....................................................................................388 SUBCHRONIC TOXICITY/TERATOLOGY/QUATERNARIES.....................................................................................................556 SUBCHRONIC TOXICITY/HEPTA-CDD/TCDD.......................................................................................................................... 1038 SUBCHRONIC TOXICITY/HEPTA-CDD/TCDD.......................................................................................................................... 1039 SUBCHRONIC TOXICITY/PATHOLOGY/HEPTA-CDD/TCDD................................................................................................. 1040 SUBCHRONIC TOXICITY/CUMENE/INHALATION...................................................................................................................1238 SUBCHRONIC TOX3CITY/ORAJUTOXICITY.............................................................................................................................. 1595 SUBUNIT ANALYSIS/GLUTATHION S-TRANFERASE/FLUOROMETRIC DETECTION....................................................... 1327 SUCCINIMIDE/ISOLATED RENAL CELLS/CYTOTOXICITY..................................................................................................... 176 SUCCINIMIDE/RENALFUNCTION/NEPHROTOXICITY............................................................................................................. 177 SUCCINIMIDE/NEPHROTOXICITY/METABOLISM.....................................................................................................................180 SULFATED POLYSACCHARIDE/OSTEOPOROSIS/BONE METABOLISM.............................................................................. 1498 SULFATION/SULFOTRANSFERASE/DRUG METABOLISM......................................................................................................1319 SULFATION/MmOXTOIL/SULFOTRANSFERASE ..................................................................................................................... 1320 SULFATION/MOLYBDENUM/GLYCOSAMINOGLYCAN......................................................................................................... 1329 SULFHYDRYLGROUPS/BIOMONITORING/HEMOGLOBIN..................................................................................................... 655 SULFIDE/TOXICITY/ANTIDOTES................................................................................................................................................. 823 548 511904 0271 SULFOTRANSFERASE/DRUG METABOLISM/SULFATION..................................................................................................... 1319 SULFOTRANSFERASE/SULFATION/MINOXIDIL .....................................................................................................................1320 SULFOTRANSFERASE/DIABETES/DRUG METABOLISM .......................................................................................................1324 SULFOTRANSFERASE/STEROID/INDUCTION.......................................................................................................................... 1328 SULFUR MUSTARD/DERMATOTOXICITY/IN VITRO................................................................................................................ 334 SULFUR MUSTARD/S KIN/ERYTHEMA....................................................................................................................................... 666 SULFUR MUSTARD/PERCUTANEOUS ABSORPTION/TOXICOKINETICS............................................................................. 669 SULFUR MUSTARD/ALKYLATION/LAMININ.......................................................................................................................... 1694 SULFURIC ACID/MORPHOMETRY/OZONE ..............................................................................................................................1230 SULFURYL FLOURIDE/EVOKED POTENTLALS/ACUTE INHALATION ................................................................................1373 SULFURYL FLUROIDE/ONCOGENICITY/INHALATION .........................................................................................................1547 SUPERABSORBENTS/SWELLING PARTICLES/INHALATION ............................................................................................... 1675 SUPERINDUCTION/GENE EXPRESSION/CYTOKINES.............................................................................................................1405 SUPEROXTOE/ESR/4-NITROQUINOLINE-N-OXIDE....................................................................................................................633 SUPEROXIDE/DICHLOROBENZENE/KUPFFER CELLS ...........................................................................................................1467 SUPEROXIDE DISMUTASE/REACTIVE OXYGEN/HYDROQUINONE..................................................................................... 598 SUPEROXIDE DISMUTASE/OXIDATIVE STRESS/MANGANESE............................................................................................ 634 SUPPRESSOR GENES/URETHANE (ETHYL CARBAMATEyMICROSATELLITES..................................................................522 SURFACE AREA/FIBERS/FRACTAL DIMENSION............................................................. 140 SURFACE LINING LAYER/OZONE/REACTIVE ABSORPTION ........................................................................... 1228 SURFACTANT PROTEIN C/TYPE B PNEUMOCYTE/RADIATION ........................................................................................... 146 SURFACTANTS/INTERFACIAL TRANSFER/NITROGEN DIOXIDE ......................................................................................... 150 SURFACTANTS/DERMATOTOXICITY/PRIMARYCULTURES.................................................................................................351 SURFACTANTS/CYTOTOXICITY/SKINKERATINOCYTES...................................................................................................... 354 SURFACTANTS/CORNEAL EPITHELIUM/DELAYED TOXICITY.............................................................................................982 SURFACTANTS/LYMPHOCYTE ................................................................................................................................................. 1401 SURFACTANTS/IN VITRO/AQUATIC......................................................................................................................................... 1649 SURVIVAL/CARCINOGENICITY/RODENT................................................................................................................................1177 SURVTVAL/SPRAGUE-DAWLEY RAT/BODYWEIGHT............................................................................................................ 1178 SURVIVAL RATES/COMPARISON STUDY/SPRAGUE-DAWLEY RATS ............................................................................... 1176 SUSCEPTIBILITY/PREDISPOSrnON/CARCINOGENESIS................... :.................................................................................. 1140 SWELLING PARTICLES/INHALATION/SUPERABSORBENTS ...............................................................................................1675 SWINE/LEAD/ABSORPTION.......................................................................................................................................................... 395 SWINE/LEAD/ABSORPTION.......................................................................................................................................................... 396 SYNERGISM/LOW-DOSE COMBINATION/MULTI-ORGAN MODEL....................................................................................... 168 SYSY CELL LINE/ACETYLCHOLINESTERASE ACTIVITY/PESTICIDE MIXTURES............................................................ 1353 T AND B LINEAGE CELLS/AUTOIMMUNTTY/METHYLMERCURY....................................................................................... 1251 T CELL/IMMUNOTOXICOLOGY/MYCOTOXIN..........................................................................................................................756 T CELL-INDEPENDENT RESPONSE/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN/IMMUNOSUPPRESSION ...................... 18 T-2 TOXIN/BONE MARROW/THYMUS .......................................................................................................................................416 T-2 TOXIN/HOST RESISTANCE/IMMUNOSUPPRESSION .......................................................................................................1404 T-BUTYLHYDROPEROXIDE/MITOCHONDRIA/CALCIUM...................................................................................................... 619 T-LYMPHOCYTE/ETHYLENE OXIDE/TRANSGENIC MICE..................................................................................................... 1236 T-LYMPHOCYTES/LEAD/FLOW CYTOMETRY..........................................................................................................................949 T47DCELLS/TCDD/GENETIC INSTABILITY ..............................................................................................................................733 TAMOXIFEN/P-GLYCOPROTEIN/EXCRETION ........................................................................................................................ 1596 TAMOXIFEN/CYTOCHROME P-450/HUMAN............................................................................................................................ 1597 TAMOXIFEN/PROLIFERATION/LIVER ......................................................................................................................................1598 TAMOXIFEN/P53 ANTIONCOGENE/HEPATOCARCINOMA ................................................................................................... 1600 TAMOXIFEN/DRUGS/GENOTOXICITY............................................................................................................................. 1601 TAMOXIFEN/32P-POSTLABELLING/HUMAN LIVER...............................................................................................................1602 TAMOXIFEN/CHROMOSOME DAMAGE/ANEUPLOIDY ......................................................................................................... 1603 TARGETS/NEPHROTOXICITY/DEHYDROGENASES ...............................................................................................................1695 TAURINE/METHYLENE DIANILINE/HEPATOTOXICITY ....................................................................................................... 1443 TAUROCHOLATE UPTAKE/CYTOCHROME P-450/LIVER SLICES ........................................................................................... 30 549 511904 0272 TAXOL/CELL PROLIFERATION/ROTENONE............................................................................................................................... . TAXOL/NEUROPATHY/AXONAL TRANSPORT..........................................................................................................................759 TCDD/GAP JUNCTIONS/LEAD (PB) ..............................................................................................................................................I37 TCDD/AH RECEPTOR/ARNT .........................................................................................................................................................234 TCDD/GENDER................................................................................................................................................................................410 TCDD/HAHS/RISK ASSESSMENT.................................................................................................................................................4H TCDD/VITELLOGENIN/ANTIESTROGEN ................................................................................................................................... 450 TCDD/CALCIUM/NEURONS.................................................................................................................................................. 508 TCDD/EGF RECEPTOR/DOWN REGULATION............................................................................................................................726 TCDD/OVARY/ESTROGEN RECEPTOR....................................................................................................................................... 730 TCDD/SEXUAL DIFFERENTIATION/BRAIN NUCLEI................................................................................................................ 731 TCDD/GENETIC INSTABIUTY/T47D CELLS ..............................................................................................................................733 TCDD/MCF-7 CELLS/MUTANTS ...................................................................................................................................................734 TCDD/HEPATOCYTES/CELL PROLIFERATION..........................................................................................................................959 TCDD/AH RECEPTOR/GENE EXPRESSION................................................................................................................................ 1024 TCDD/AH RECEPTOR/IMMUNOASSAY ....................................................................................................................................1025 TCDD/AH RECEPTOR/DNA BINDING ........................................................................................................................................1026 TCDD/EMBRYONIC/AH RECEPTOR...........................................................................................................................................1028 TCDD/CHROMOSOME 7/AH RECEPTOR...................................................................................................................................1031 TCDD/EXPRESSION/AH RECEPTOR............................................................................................................................................1032 TCDD/BENZO[A]PYRENE/AH RECEPTOR ................................................................................................................................ 1034 TCDD/ADIPOSE TISSUE/GLUCOSE TRANSPORT.....................................................................................................................1035 TCDD/SUBCHRONIC TOXICITY/HEPTA-CDD.......................................................................................................................... 1038 TCDD/SUBCHRONIC TOXICITY/HEPTA-CDD........................................................................................... TCDD/FEMALE RATS/BIOCHEMICAL EFFECTS........................................................................................ TCDD/FEMALE/TOXICOKINETICS............................................................................................................................................. 1042 TCDD/TOXICOKINETICS/LONG-EVANS RAT.......................................................................................................................... 1043 TCDD/HUMAN BLOOD/DISTRIBUTION ....................................................................................................................................1044 TCDD/PHARMACOKINETICS/AGING ........................................................................................................................................1046 TCDD/CYTOCHROME P-450/METABOLISM.............................................................................................................................. 1047 TCDD/IN VITRO/CONTINUOUS DOSING ..................................................................................................................................1048 TCDD/PCBS/TOXIC EQUIVALENCY ..........................................................................................................................................1065 TCDD/PROLACTTN/APOPTOSIS .................................................................................................................................................. 1159 TCDD/EXTRATHYMIC T-CELLS/AUTOIMMUNITY................................................................................................................. 1253 TCDD/THYMUS/MECHANISM..................................................................................................................................................... 1394 TCDD/THYMIC ATROPHY/BCL-2 TRANSGENIC MICE........................................................................................................... 1395 TCDD/SPERMATOGENESIS/IN UTERO AND LACTATIONAL ............................................................................................... 1499 TCDD/MALE REPRODUCTIVE SYSTEM/ANDROGEN PRODUCTION.................................................................................... 1501 TCDD/SEX DIFFERENTIATTON/REPRODUCnVE ALTERATIONS..........................................................................................1502 TCDD/CYTOCHROME P-450/SEX DIFFERENCE .......................................................................................................................1504 TCDD/GLUCONEOGENESIS/APPETITE SUPPRESSION........................................................................................................... 1505 TCDD/P53/MDM2 GENE ............................................................................................................................................................... 1506 TCDD/ANTIESTROGENICITY/CHLORINATED AZO(XY)BENZENES .................................................................................... 1507 TCDD/OSTEOBLAST/DIFFERENTIATION.................................................................................................................................. 1508 TCDD/KERATTNOCYTES/IL-1 BETA............................................................................................................................................ 1509 TCDD/PEROXISOME PROLIFERATION/CYTOCHROME P-450 ................................................................................................1510 TCDD/PKC/CELL CYCLE ............................................................................................................................................................. 1511 TCDD/CHLORPROMAZINE/rOXICITY ...................................................................................................................................... 1512 TCDD/IN VITRO/POLYCYCLIC AROMATIC HYDROCARBONS ............................................................................................1514 TCDD/NATURAL KILLER ACTIVITY/INFLUENZA VIRUS ......................................................................................................1515 TCDD/RISK ASSESSMENT/DOSE-RESPONSE ...........................................................................................................................1516 TCDD/RISK ASSESSMENT/DOSE-RESPONSE ...................................................................................... 1517 TCDD/ONCOGENES/CARCINOGENESIS.....................................................................................................................................1518 TCDD/AH RECEPTOR/PROTEOLYSIS .......................................................................................................................................1518a TCDD/REPRESSION/OVARLAN CELLS ...................................................................................................................................... 1615 550 511904 0273 TCDD/CYTOCHROME P-150/AH RECEPTOR ............................................................................................................................ 1616 TCDD/CYTOCHROMEP-450/CDNA ............................................................................................................................................1618 TCDD/CYTOCHROME P-450 ..................... 1619 TCDD/CLONING/AH RECEPTOR............................................................................................................................... 1620 TCDD/RECEPTORS/CELL PROLIFERATION.............................................................................................................................. 1625 TCDD/TH YMU S/PROTEASES........................................................................................................................... 1626 TCDD/PROTEASES/KERATTNOCYTES ................................................................................................. 1627 TCDD DOSIMETRY/EGF RECEPTOR/MECHANISTIC MODELING .........................................................................................725 TCDD OR DIOXIN/MOLECULAR/ESTROGEN RECEPTORS .................................................................................................... 729 TEMPERATURE/REPRODUCTIVE PERFORMANCE/INTRAVENOUS INFUSION ..................................................................221 TEMPERATURE/MITROGENESIS/CARCINOGENESIS.............................................................................................................. 433 TEMPORAL RESPONSE DIFFERENTIATION/METHAMPHETAMINE/PHENCYCLIDINE .................................................... 305 TERATOGENESIS/P53/BENZO(A)PYRENE................................................................................................................................. 940 TERATOGENESIS/CYCLOPHOSPHAMIDE/APOPTOSIS ........................................................................................................... 1422 TERATOGENESIS/AVLAN/DYSMORPHOGENESIS .................................................................................................................. 1503 TERATOGENICITY/4-VINYLCYCLOHEXENE/OVARIANTOXICITY ..................................................................................... 586 TERATOLOGY/QUATERNARIES/SUBCHRONIC TOXICITY.................................................................................................... 556 TERATOLOGY/GLYCOL/TRIETHYLENEGLYCOL.................................................................................................................... 571 TERATOLOGY/DEVELOPMENTALTOXICITY/UTHIUM ............................................................................................. TERATOLOGY/PROPELLANT/XM46 ........................................................................................................................................... 585 TERATOLOGY/INFUSION/RATS.................................................................................................. TERATOLOGY/REPRODUCTIVETOXICITY/REPELLENT........................................................................................................ 925 TERT-B UTYL-HYDROXYANISOLE/GLUTATHIONE/NEPHROTOXICnY............................................................................. 651 TEST GUIDELINES/NEUROTOXICITY/EVOKED POTENTIALS ............................................................................................. 1374 TESTES/SEMEN/HISTOPATHOLOGY...........................................................................................................................................206 TESTES/EPIDIDYMIS/ESTROGEN................................................................................................................................................. 209 TESTES/HEME OXYGENASE/HEAT SHOCK ................................................................................................................................261 TESTES/IN VITRO/2-METHOXYETHANOL................................................................................................................................. 264 TESTES/HISTOPATHOLOGY/SEMEN........................................................................................................................................... 266 TESTES/SPERMATOGENESIS/FUNGICIDE................................................................................................................................. 267 TESTES/LDH/VCN .......................................................................................................................................................................... 268 TESTES/PITUTTARY HORMONES/TESTICULAR TUMORS...................................................................................................... 460 TESTES/APOPTOSIS/2-METHOXYETHANOL............................................................................................................................ 1157 TESTICULAR METABOLISM/CYTOCHROME P-450 1 A/GLUTATHIONE TRANSFERASES ................................................ 262 TESTICULAR TOXICITY/1,3-DINITROBENEZENE METABOLISM/ROUTE OF ADMINISTRATION................................... 265 TESTICULAR TUMORS/TESTES/PITUITARY HORMONES...................................................................................................... 460 TESTIS/RECOVERY/BORIC ACID.................................................................................................................................................270 TESTIS/SERTOLI CELL/HSP27/STRESS PROTEIN/CADMIUM...................................................................................................269 TETRACHLOROAZOBENZENE/TETRACHLOROAZOXYBENZENE/EXCRETION.............................................................. 1724 TETRACHLOROAZOXYBENZENE/EXCRETION/TETRACHLOROAZOBENZENE.............................................................. 1724 TETRACHLOROETHYLENE/PBPK/BREAST MILK ...................................................................................................................... 86 TETRACHLOROETHYLENE/EXPOSURE-RESPONSE/TOLUENE........................................................................................... 1584 TETRACHLOROETHYLENE/MODELINGERROR/EXPOSURE-RESPONSE .......................................................................... 1585 TETRACHLORVINPHOS/OCULAR/EYE....................................................................................................................................... 978 TETRYL/DRUG METABOLIZING ENZYMES/MUNITION CHEMICAL ................................................................................... 706 TGF-a/UTERUS/NEOPLASIA.........................................................................................................................................................466 TGF-ALPHA/HEPATIC TUMOR PROMOTION/TRANSGENIC MICE......................................................................................... 962 THALLIUM/MONOAMINES/TURNOVER RATE........................................................................................................................ 1022 THAPSIGARGIN/CALCIUM/APOPTOSIS.................................................................................................................................... 1425 THERMAL EMISSIONS/SENSORY IRRITATION/RESINS.......................................................................................................... 972 THERMAL EMISSIONS/SENSORY IRRITATION/INHALATION ............................................................................................. 1205 THERMAL EMISSIONS/SENSORY IRRITATION/INHALATION ..............................................................................................1206 THERMOREGULATION/ORGANOPHOSPHATES/CHLORPYRIFOS........................................................................................1354 THIN LAYER CHROMATOGRAPHY/HIGH PRESSURE LIQUID CHROMATOGRAPHY/COCAINE.................................... 1565 THIN-LAYER CHROMATOGRAPHY/ARSENIOGLUTATHIONE ............................................................................................1017 577 551 511904 0274 THIOACETAMIDE/AUTOPROTECTION/TISSUE REPAIR............................................................................................................. THIOCYANATE/3-MERCAPTOPRYlTVATE/CYANIDE.............................................................................................................. 822 THIOL HOMEOSTASIS/CADMIUM/CYTOS KELETON .............................................................................................................. 880 THIOLS/PROTEIN OXIDATION/PHENOXYL RADICAL ............................................................................................................ 364 THIOLS/OXIDATIVE STRESS/MOUSE HEPATOCYTES ............................................................................................................ 606 THIRAM/PREGNANCY/DELAYED OVULATION........................................................................................................................216 THROMBOCYTOPENIA/ADITOPRIM/ANEMIA........................................................................................................................ I550 THYMIC ATROPHY/BCL-2 TRANSGENIC MICE/TCDD...........................................................................................................1395 THYMOCYTE SUBPOPULATIONS/COCAINE/FLOW CYTOMETRY ................................................................................... 1254c THYMOCYTES/DNA FRAGMENTS/APOPTOSIS ...................................................................................................................... 1161 THYMOCYTES/FLOW CYTOMETRY/2-METHOXYETHANOL ............................................................................................... 1252 THYMOCYTES/APOPTOSIS/PROTEIN SYNTHESIS................................................................................................................. 1426a THYMOCYTES/IN UTERO EXPOSURE/2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN .........................................................1500 THYMUS/T-2 TOXIN/BONE MARROW ....................................................................................................................................... 416 THYMUS/IMMUNOTOXICITY/SCID MOUSE............................................................................................................................. 480 THYMUS/APOPTOSIS/2-METHOXYETHANOL ........................................................................................................................ 1156 THYMUS/IMMUNOTERATOLOGY/FETAL ALCOHOL SYNDROME......................................................................................1245 THYMUS/MECHANISM/TCDD............................................................................................................................... 1394 THYMUS/PROTEASES/TCDD....................................................................................................................................................... 1626 THYROID/PROLIFERATION/PROMOTION............................. 426 THYROID/HORMONALLY-MEDIATED/CARCINOGENESIS.....................................................................................................461 THYROID/N-BUTYL-1 -DEOXYNOJIRMYCIN/AIDS .................................................................................................................. 530 THYROID HORMONES/GOLTROGEN/FLAVONOIDS...............................................................................................................1294 THYROTOXIC/POLYCHLORINATED BIPHENYLS/ESTROGENIC..........................................................................................1058 THYROXINE/GLUCURONIDATION/UDP-GLUCURONOSYLTRANSFERASE...................................................................... 1321 THYROXINE/FOE 5043/LIVER..................................................................................................................................................... 1535 TIO2/ORGAN CULTURE/LUNG ..................................................................................................................................................... 153 TISSUE/RESOURCE/HUMAN....................................................................................................................................................... 1138 TISSUE CREATINE/b-GUANIDINOPROPIONIC ACID/METHODS........................................................................................... 1570 TISSUE REPAIR/DIBENAMINE/CARBON TETRACHLORIDE.................................................................................................... 40 TISSUE REPAIR/THIOACETAMIDE/AUTOPROTECTION............................................................................................................ 41 TISSUE REPAIR/APOPTOSIS/EARLY GENE EXPRESSION ..................................................................................................... 1180 TISSUE REPAIR/DOSE-RESPONSE/RISKASSESSMENT ......................................................................................................... 1432 TISSUE REPAIR/POSTNATAL DEVELOPMENT/CARBON TETRACHLORIDE.......................................................................1461 TISSUE SLICES/TRICHLOROETHYLENE/CYTOTOXICITY.........................................................................................................35 TISSUE SPECmCITY/GENE EXPRESSION/DIFFERENTIATION............................................................................................... 439 TISSUE SPECIFICITY/IN VITRO/STRESS RESPONSE ................................................................................................................ 447 TITANIUM OXIDE PARTICLES/TUMOR NECROSIS FACTOR/MACROPHAGES.................................................................... 900 TNF/ENDOTOXIN/TNTERFERON-GAMMA..................................................................................................................................944 TNF/OZONE/PERMEABILITY....................................................................................................................................................... 1232 TNF (TUMOR NECROSIS FACTORVTOXIC ALVEOLITIS/DUST............................................................................................... 273 TNF-a/HEPATOCYTES/PERICENTRAL TOXICITY ................................................................................................................... 1444 TOBACCO SMOKE/LUNG CANCER/ARTERIOSCLEROTIC.......................................................................................................718 TOBACCO SMOKE/GLUTATHIONE S-TRANSERASES SUBUNITS/FERRETS.......................................................................1326 TOBACCO SMOKE/ENZYME-LINKED IMMUNOSORBENT ASSAY/COTININE ................................................................... 1562 TOCOLYTIC AGENT/GENERAL TOXICOLOGY/RWJ-22164 ..................................................................................................... 832 TOLERANCE/ACETYLCHOLINESTERASE/PARAOXON........................................................................................................... 913 TOLERANCE/ACETYLCHOLINESTERASESARAOXON...........................................................................................................914 TOLUENE/TRICHLOROETHYLENE/NEUROTOXICITY........................................................................................................... 1335 TOLUENE/TETRACHLOROETHYLENE/EXPOSURE-RESPONSE............................................................................................ 1584 TOLUENE DIISOCYANATE/SENSITIZATION/ADDUCTS......................................................................................................... 1409 TOLUENE DnSOCYANATE/SENSmZATION/MURINE MODEL ............................................................................................ 1607 TOLUENE DIISOCYANATE (TDiyiSOLATED, PERFUSED LUNG/REACTTVITY...................................................................1239 TOPICAL SKIN PROTECTANT/ACETYLCHOUNESTERASE/SKIN PENETRATION...............................................................341 TOPOISOMERASES/GENE REGULATION/CELL PROLIFERATION..........................................................................................446 552 511904 0275 TOTAL PARENTERAL NUTRITION/NEPHROTOXICITY/CYCLOSPORIN.............................................................................. 1181 TOULENE DIISOCYNATE (TDIVBIOMARKERS/GC-MS ANALYSIS ...................................................................................... 1412 TOXIC ALVEOLinS/DUST/TNF (TUMOR NECROSIS FACTOR)............................................................................................... 273 TOXIC CYSTEINE CONJUGATES/RENAL INJURY CATTLE/APLASTIC ANAEMIA............................................................... 194 TOXIC EQUIVALENCY/TCDD/PCBS ..........................................................................................................................................1065 TOXIC EQUIVALENCY FACTORS/RISK ASSESSMENT/PESTICIDES ....................................................................................1540 TOXICITY/RICIN/INHALATION/AEROSOL.................................................................................................................................. 145 TOXICITY/CELL PROLIFERATION/IN VITRO TESTING .......................................................................................................... 316 TOXICITY/IN VITRO/DERMAL ..................................................................................................................... 350 TOXICITY/VCN/IMMUNE FUNCTION ........................................................................................................................................... TOX1CITY/PLACENTA/ANTI-HIV................................................................................................................................................. 526 TOXICITY/PICLORAM/DEVELOPMENTAL TOXICITY ............................................................................................................ 579 TOXICITY/2,4-D/DEVELOPMENTAL TOXICITY........................................................................................................................ 580 TOXICITY/KIDNEY/FUMONISIN................................................................................................................................................... 774 TOXICITY/URETHANE/ALCOHOL............................................................................................................................................... 789 TOXKTTY/BRB-I-28/GLG-V-13 ..................................................................................................................................................... 806 TOXICITY/DOXORUBICIN/LIPOSOME....................................................................................................................................... 812 TOXICITY/CYTOKINE/INTERLEUKIN-12................................................................................................................................... 820 TOXICITY/ANTIDOTES/SULFIDE................................................................................................................................................. 823 TOXICITY/CADMIUM/ETHANOL............................................................. 882 TOXICITY/IN VITRO BACTERIAL ASSAY/NICKEL ................................ 901 TOXICITY/CHROMIUM/ANTIOXIDANT SYSTEM...................... 1005 TOXICTTY/TCDD/CHLORPROMAZINE ......................................................................................................................................1512 TOXICITY/SUBCHRONIC TOXICITY/ORAL.............................................................................................................................. 1595 TOXICITY/COMBUSTION/CHLORINATED HYDROCARBONS ............................................................................................. 1648 TOXICITY/BOTULINUM/INHALATION/AEROSOL...................................................................................................................1670 TOXICITY/SEB/INHALATTON/AEROSOL .................................................................................................................................. 1671 TOXICITY ASSESSMENTS/HAZARD EVALUATION/MECHANISMS ....................................................................................1633 TOXICITY PARAMETERS/DERMAL/JACKETS ..........................................................................................................................674 TOXICITY STUDIES/RISK ASSESSMENT/CALORIC RESTRICTION ....................................................................................... 934 TOXICITY TESTING/EMBRYO LARVAL/FUNGAL CONTAMINATION ................................................................................1628 TOXICODYNAMICS/REDOX CYCLING/DICHLOROFLUOROSCEIN....................................................................................... 625 TOXICOKINETIC MODELS/RISK ASSESSMENT/LEAD .............................................................................................................. 56 TOXICOKINETICS/RISK ASSESSMENT/CADMIUM .................................................................................................................... 62 TOXICOKINETICS/MIXTURES/SOLVENTS................................................................................................................................... 69 TOXICOKINETICS/MIXTURES/HALOGENATED HYDROCARBONS ....................................................................................... 70 TOXICOKINETICS/MIXTURES/GASES/VAPORS.......................................................................................................................... 71 TOXICOKINETICS/MIXTURES/SOLVENTS................................................................................................................................... 72 TOXICOKINETICS/MIXTURES/ENVIRONMENTAL.................................................................................................................... 73 TOXICOKINETICS/PBPK MODEL/PYRENE................................................................................................................................... 75 TOXICOKINETICS/STYRENE/STYRENE OXIDE ..................... 80 TOXICOKINETICS/TRICHLOROETHYLENE/ENTEROHEPATICRECIRCULATION................................................................ 83 TOXICOKINETICS/PB-TK MODELING/3-D VISUALIZATION.....................................................................................................84 TOXICOKINETICS/BONE LEAD/BLOOD-LEAD..........................................................................................................................259 TOXICOKINETICS/BIOTRANSFORMATION/ANQ-3598 ............................................................................................................ 375 TOXICOKINETICS/BIOTRANSFORMATION/SOLVENTS.......................................................................................................... 380 TOXICOKINETICS/CHEMICAL MlXTURES/CELL PROLIFERATION ..................................................................................... 381 TOXICOKINETICS/CHROMIUM/BIOAVAILABILITY................................................................................................................ 383 TOXICOKINETICS/ETHYLENE OXIDE/IN VTVO/IN VITRO...................................................................................................... 384 TOXICOKINETICS/CHICKENS/ACRYLAMIDE............................................................................................................................385 TOXICOKINETICS/NEUROTOXICITY/DOMOIC ACID.............................................................................................................. 386 TOXICOKINETICS/CARDIOVASCULAR/DRUG.......................................................................................................................... 389 TOXICOKINETICS/ETHANOL/XLENE......................................................................................................................................... 394 TOXICOKINETICS/BIOTRANFORMATION, PHASE I/MIXTURES ........................................................................................... 397 TOXICOKINETICS/SULFUR MUSTARD/PERCUTANEOUS ABSORPTION..............................................................................669 553 511904 0278 TOXICOKINETTCS/CHLOROPENTAFLUOROBENZENE/DERMALABSORPTION ....................................................... TOXICOKINETICS/PROSTAGLANDIN SYNTHESIS INHIBITOR/CYTOCHROME P-450 INDUCTION..................... - 70s TOXICOKINETICS/HYDROGEN SULFIDE/AIR STANDARDS.......................................................................................... " ' TOXICOKINETICS/NICKEL COMPOUNDS/LUNG CLEARANCE .................................................................................. .. 903 TOXICOKINETICS/TCDD/FEMALE........................................................................................................................................ '1042 TOXICOKINETICS/LONG-EVANS RAT/TCDD ..................................................................................................................... 'I043 TOXICOKINETICS/MODEL SIMULATION/PCDD/PCDF......................................................................................................' 1045 TOXICOKINETICS/CHLOROFORM/DOSIMETRY ................................................................................................................. 1054 TOXICOKINETICS/UVER EXPLANTS/TRICHLOROETHYLENE ...................................................................................... ', og6 TOXICOKINETICS/1,1,1 -TRICHLOROETHANE/NEUROBEHAVIORAL............................................................................. 1370 TOXICOKINETICS/DISPOSITION/ACRYLIC ACID ............................................................................................................. ' 1704 TOXICOKINETICS/DISPOSITION/ACRYLIC ACID .................................................................................................................... TOXICOLOGICAL SCREEN/CELL CYCLE/FERTILITY ASSAY........................................................................................... . 208 TOXICOLOGY/FEMALE/REPRODUCITVE ................................................................................................................................ 224 TOXICOLOGY/ARSENIC/COMPARATTVE.................................................................................................................................. . TOXICOLOGY/ONCOGENES/TRANSGENE................................................................................................................................ . TOXICOLOGY/CARCINOGENESIS/HUMAN............................................................................................................................ .. TRACHEA/POLYSORBATES/CILIA ...........................................................................................................................................1674 TRAINING/ENVIRONMENTAL/PUBLIC HEALTH ASSESSMENT................................................................ 288 TRANSAMINASE/ESTROGEN/LIVER FUNCTION.....................................................................................................................693 TRANSCRIPTION/ANTIESTROGEN/ER/SP1 INTERACTION .....................................................................................................47 TRANSCRIPTION/IN VITRO ASSAY/LIVER .............................................................................................................................. 314 TRANSCRIPTION FACTOR/METABOUSM/OXIDATIVE DAMAGE........................................................................................442 TRANSCRIPTION FACTOR KB/CELL DENSITY/HUMAN LYMPHOBLASTOID CELLS....................................................... 449 TRANSCRIPTION FACTOR-BINDING SITES/[AH] GENE BATTERY/ALDEHYDE DEHYDROGENASE ...........................1621 TRANSCRIPTION FACTOR-BINDING SITES/[AH] GENE BATTERY/UDP GLUCURONOSYLTRANSFERASE GENE ... 1622 TRANSCRIPTION FACTOR-BINDING SITES/]AH] GENE BATTERY/ALDEHYDE DEHYDROGENASE GENE ............... 1623 TRANSCRIPTION FACTORS/OXYR/OXIDAnVE STRESS....................................................................................................... 445 TRANSFORMATION/RISK ASSESSMENT/METALS ...................................................................................................................63 TRANSFORMATION/NICKEL/RETINOBLASTOMA GENE......... :........................................................................................... 523 TRANSFORMING GROWTH FACTOR-a/MACROPHAGES/12-O-TETRADECANOYLPHORBOL-13-ACETATE.................467 TRANSGENE/INTESTINE/PROTOCOLS........................................................................................................................................ 10 TRANSGENE/TOXICOLOGY/ONCOGENES................................................................................................................................ 938 TRANSGENIC/INDUCTION/METALLOTHIONEIN..................................................................................................................... 890 TRANSGENIC/MUTATION/1,3-BUTADIENE .............................................................................................................................942 TRANSGENIC/CHEMOKINE/INFLAMMATION......................................................................................................................... 945 TRANSGENIC ANIMALS/VALIDATION/MUTAGENICITY ......................................................................................................939 TRANSGENIC MICE/MUTAGENICITY/BENZO(A)PYRENE......................................................................................................941 TRANSGENIC MICE/TGF-ALPHA/HEPATIC TUMOR PROMOTION........................................................................................ 962 TRANSGENIC MICE/T-LYMPHOCYTE/ETHYLENE OXIDE.................................................................................................... 1236 TRANSLATION/ENZYME INDUCTION/CYTOCHROME P-450 ................................................................................................ 106 TRANSPLACENTAL/5, 8,11,14-EICOSATETRAYNOIC ACID/PEROXIDASES....................................................................... 588 TRANSPLANTATION/GLYCINE/CAROLINA RINSE................................................................................................................. 620 TRANSPLANTATION/IMMUNOSUPPRESSION/CORTICOSTEROIDS................................................................................... 1249 TRANSPORT/M-741/HEPATIC SLICE ............................................................................................................................................ 34 TRANSPORT/ORGANIC CATIONS/PROXIMAL TUBULE.......................................................................................................... 161 TRANSPORT/TUBULES/BENZYL QUINOLINIUM...................................................................................................................... 188 TRANSPORT/MANGANESE/BLOOD-BRAIN BARRIER ..........................................................................................................."8 TRANSPORTERS/DICHLOROETHYLENE/BILE........................................................................................................ 680 TRIAZOLOPYRIMIDINE SULFONAMIDE/METABOLISM/COMPARATIVE............................................................................393 TRICHLOROACETATE/BROMODICHLOROACETATE/OXALATE......................................................................................... 1464 TRICHLOROACETATE (TCAyDICHLOROACETATE (DCA)/PHARMACOKINETICS............................................................ 383 TRICHLOROETHYLENE/CYTOTOXICITY/TISSUE SLICES........................................................................................................ 35 TRICHLOROETHYLENE/PBPK MODELING/CYTOCHROME P-450 ...........................................................................................67 TRICHLOROETHYLENE/CARBON TETRACHLORIDE/PHARMACOKINETIC MODELING ...................................................78 TRICHLOROETHYLENE/ENTEROHEPATIC RECIRCULATION/TOXICOKINETICS................................................................ 83 TRICHLOROETHYLENE/INFECTION/CHLOROFORM................................................................................... ' ' '4)8 TRICHLOROETHYLENE/DERMAL BIOAVAILABIL1TY/SOIL...................................................................................................673 TRICHLOROETHYLENE/METABOLISM/KINETICS ................................................................................................................ 1082 TRICHLOROETHYLENE/METABOLISM/STRAINCOMPARISONS ....................................................................................... 1083 TRICHLOROETHYLENE/METABOLISM/PHARMACOKINETICMODELING........................................................................ 1084 TRICHLOROETHYLENE/SPECIES COMPARISON/DICHLORVINYLCYSTEINE .................................................................. 1085 TRICHLOROETHYLENETOXICOKINETICS/LIVEREXPLANTS ........................................................................................... 1086 TRICHLOROETHYLENE/NEUROTOXICITY/TOLUENE...........................................................................................................1335 TRICHLOROETHYLENE/TRIGEMINAL NERVE/EVOKED POTENTIALS .................................................................. TRICHLOROETHYLENE/MIXTURES/CHLOROFORM............................................................................................... TRICHOLORETHYLENE/DICHLOROACETATE/METABOLISM............................................................................................j081 TRICHOTHECENES/INTERLEUKINS/GENE EXPRESSION ......................................................................................... TRIETHYLENE GLYCOLGERATOLOGY/GLYCOL....................................................................................................................571 TRIETHYLENE GLYCOL/AEROSOL/SENSORY IRRITATION.................................................................................................1207 TRIGEMINAL NERVE/EVOKED POTENTIALS/TRICHLOROETHYLENE..............................................................................1364 TRIHALOMETHANES/DNA REPAIR/GENOTOXICITY............................................................................................................ 1279 TRHODOTHYRONINE/BILIARY EPITHELIUM/CELL PROLIFERATION............................................................................... 1092 TRIMELLITTC ANHYDRIDE/LUNG/COMPLEMENT ................................................................................................................ 1611 TRIMETHYLTIN/LEARNING/NEUROTOXICrTY............................................................................................................ TRIMETHYLTIN/MAP-2/NCAM.................................................................................................................................................... 504 TRIMETHYLTIN/CYTOKINES/GLIAL FIBRILLARY ACIDIC PROTEIN...................................................................................505 TRIMETHYLTIN/NTTRIC OXIDE/NITRIC OXIDE SYNTHASE.................................................................................................. 739 TRINTTROBENZENE/REPRODUCnON/NEUROTOXICITY...................................................................................................... 574 TRINITROBENZENE/DRUG METABOLIZING ENZYMES/MUNITION CHEMICALS ............................................................709 TRINITROTOLUENE (TNT)/BIOAVAILABLE/COMPOST........................................................................................................ 1636 TRIPHENYL PHOSPHITE/VISUAL SYSTEM/DEGENERATION...............................................................................................1339 TRIPHENYLETHYLENE DRUGS/HEPATOCARCINOGENICITY/DNA ADDUCT FORMATION ......................................... 1599 TROUT/DEHYDROEPIANDROSTERONE/PEROXISOME PROLIFERATION.......................................................................... 1171 TROUT/PERSISTANCE(T I/2VACRYLONITRILE......................................................................................................................1713 TUBULES/BENZYL QUINOLINIUM/TRANSPORT......................................................................................................................188 TUBULIN/DIETHYLSTILBESTROL/ESTRADIOL....................................................................................................................... 458 TUMOR/ALBUMIN/ESTROGEN.................................................................................................................................................... 454 TUMOR DEVELOPMENT/ISOPRENE/CARCINOGENESIS ........................................................................................................ 469 TUMOR NECROSIS FACTOR/ENDOTOXIN/KUPFFER CELLS.................................................................................................. 247 TUMOR NECROSIS FACTOR/PROPIDIUMIODIDE/CYTOTOXICITY ASSAY ....................................................................... 406 TUMOR NECROSIS FACTOR/RICIN/OXIDATIVE STRESS........................................................................................................781 TUMOR NECROSIS FACTOR/MACROPHAGES/TITANIUM OXIDE PARTICLES................................................................... 900 TUMOR NECROSIS FACTOR/PCB/KUPFFER CELL.................................................................................................................. 1064 TUMOR NECROSIS FACTOR/LANGERHANS CELLS/SKIN SENSITIZATION ...................................................................... 1605 TUMOR NECROSIS FACTOR-ALPHA/PHOSGENE/ALVEOLAR MACROPHAGES ................................................................752 TUMOR PROMOTERS/PHOSPHORYLATION/GAP JUNCTIONS............................................................................................... 135 TUMOR PROMOTERS/MULTISTAGE CARCINOGENESIS/HALOGENATED PESTICIDE .................................................... 463 TUMOR PROMOTION/9-ANTHRONES/PROTEIN KINASE C.................................................................................................... 676 TUMORIGENIC/MANUFACTURED GAS PLANT RESIDUE/STRAIN A MICE......................................................................... 470 TUMOUR-SUPPRESSOR/CARCINOGENESIS/P53........................................................................................................................521 TURNOVER RATE/THALLIUM/MONOAMINES........................................................................................................................ 1022 TYPE II CELLS/PULMONARY INJURY/ALKALINE PHOSPHATASE........................................................................................148 TYPE II CELLS/SILICON DIOXIDE/NITRIC OXIDE....................................................................................................................745 TYPE IIPNEUMOCYTE/RADIATION/SURFACTANT PROTEIN C ........................................................................................... 146 TYROSINAEMIA/4-HYDROXYPHENYLPYRUVATE DIOXYGENASE/INBORN ERROR OF METABOLISM...................... 826 TYROSINE/FREE RADICALS/CARBON TETRACHLORIDE.......................................................................................................368 TYROSINE HYDROLAYSE/LASER-SCANNING CONFOCAL MICROSCOPY/POLYCHLORINATED BIPHENYLS..........1372 U-SHAPED/DOSE-RESPONSE/RISK ASSESSMENT...................................................................................................................1427 UBIQUITIN/BROMOPHENYLACTYLUREA/NEUROPATHY................................................................................................... 1357 1364 1471 754 303 \ 555 UDP GLUCURONOSYLTRANSFERASE GENE/TRANSCRIPTION FACTOR-BINDING SITES/[AH] GENE BATTERY ... 1622 UDP-GLUCURONOSYLTRANSFERASE/THYROXINE/GLUCURONIDATION...................................................................... 1321 UDP-GLUCURONOSYL TRANSFERASE/GENE REGULATION/GLUCURONIDATION......................................................... 1323 UDP-GLUCURONOSYLTRANSFERASE/ETHANOL/CLONING............................................................................................... 1322 ULTRASTRUCTURE/MONKEY OVARY/HEXACHLOROBENZENE......................................................................................... 211 ULTRASTRUCTURE/MICROANALYSIS/GADOLINIUM............................................................................................................ 243 ULTRAVIOLETLIGHT/BENZO(A)PYRENE/IMMUNOTOXICOLOGY ........................................................................................14 ULTRAVIOLET RADIATION/IMMUNOLOGY/SKIN .................................................................................................................. 478 UNCERTAINTY/SAFETY...............................................................................................................................................................1587 UNCERTAINTY ANALYSIS/MONTE CARLO SIMULATION/CHEMICAL/RADIATION DOSE ........................................... 1149 UNCERTAINTY FACTORS/REFERENCE DOSE/CHLORINATED COMPOUNDS .................................................................. 1591 UNDERGRADUATE RESEARCH/OUTREACH/PRECOLLEGE EDUCATION............................................................................285 UNSCHEDULED DNA SYNTHESIS/LIVER SLICES/2-ACETYLAMINOFLUORENE.................................................................. 29 UPPER RESPIRATORY TRACT/FISCHER 344 RAT/PARTICLE ................................................................................................. 143 UPPER RESPIRATORY TRACT/RISK ASSESSMENT/NASAL TOXICITY ................................................................................ 155 UPPER RESPIRATORY TRACT/DIMETHYL SULFATE/DNA ADDUCTS................................................................................ 1216 URETHANE/DEVELOPMENTALTOXICITY/METALLOTHIONEIN ......................................................................................... 568 URETHANE/YOLK SAC/METALLOTHIONEIN MRNA .............................................................................................................. 569 URETHANE/ALCOHOL/TOXICITY................................................................................................................ 789 URETHANE (ETHYL CARBAMATEyMICROSATELLITES/SUPPRESSOR GENES.................................................................. 522 URINARY BLADDER/ALPHA-2-MICROGLOBULIN/KIDNEY................................................................................................... 171 URINARY MARKERS/LDHISOENZYMES/NEPHROTOXICITY ................................................................................................173 URINARY METABOLITES/METABOLISM/4-METHYLHEPTANE............................................................................................1291 URINARY METABOLITES/BENZO(A)PYRENE/ADDUCTS ..................................................................................................... 1416 URINARY PORPHYRINS/MERCURY/DMPS ............................................................................................................................... 998 URINE/SODIUM SAACHARIN/MALE/FEMALE ..........................................................................................................................438 UROPORPHYRIN/5-AMINOLEVULINATE/ASCORBIC ACID ................................................................................................. 1103 UTERINE CONTRACTION/CYCUCAMP/UNDANE.................................................................................................................. 225 UTERINE CONTRACnON/PARTURITION/DCB.......................................................................................................................... 226 UTERUS/NEOPLASIA/TGF-a ........................................................................................................................................................ 466 UTP POOLS/MICROTUBULES/GLUTATHIONE .......................................................................................................................... 879 UV/CYTOKINES/KERATINOCYTES............................................................................................................................................. 339 UVB/SKIN/NITRIC OXIDE.............................................................................................................................................................. 742 V79 CELLS/MUCONALDEHYDE METABOLITES/MUTAGENICITY ........................................................................................852 VACCINATION/LUNG/RICIN.........................................................................................................................................................779 VACCINE/DEVELOPMENTAL TOXICITY/MNRGP120 ...............................................................................................................527 i VACCINE/IMMUNIZATION/RICIN ...............................................................................................................................................780 VALIDAnON/MUTAGENICITY/TRANSGENICANIMALS .......................................................................................................939 VALIDATION/CLOTH PATCH TECHNIQUES/PESTICIDES ......................................................................................................1660 VALIDATION STUDY/MUTAGENTICITY/GENOTOXICITY ..................................................................................................... 851 VALPROIC ACID/OVULATION/CATECHOLAMINES.................................................................................................................215 VANCOMYCIN/NEPHROTOXICITY/KALLIKREIN .....................................................................................................................174 VAPOR INHALATION/HYDROGEN CHLORIDE/CHLOROSILANES ...................................................................................... 1198 VAPOR INHALATION/HYDROGEN CHLORIDE/CHLOROSILANES .......................................................................................1199 VAPOR UPTAKE/ACETALDEHYDE/NASAL CAVITY............................................................................................................... 1194 VASCULAR/NTTRIC OXIDE (NO)/CYANIDE................................................................................................................................ 743 VCN/TESTES/LDH ...........................................................................................................................................................................268 VCN/IMMUNE FUNCTION/TOXICITY ..........................................................................................................................................413 VEHICLE/CARBON TETRACHLORIDE/CHLOROFORM........................................................................................................... 1050 VEHICLE EFFECTS/LINDANE/DERMAL DISTRIBUTION ......................................................................................................... 338 I VEHICLES/METHODS/LOCOMOTOR ACTIVITY.........................................................................................................................298 VENOM/WASP/PROTEIN STRUCTURE ........................................................................................................................................785 VERAPAMIL/XYLAZINE/KETAMINE/PROPOFOL ....................................................................................................................... 805 VIABILITY/CARDIAC MYOCYTES/ISCHEMIA/REPERFUSION ................................................................................................308 VINCA ALKALOIDS/RENAL TRANSPORT/ANTINEOPLASTIC DRUGS ...................................................................................186 nm m y m p y *>.t 556 511904 0279 VINYL ACETATE/NASAL METABOLISM/MODELING............................................................................................................. 1209 22 VINYL FLUORIDE/ETHENOGUANINE/DNA ADDUCTS........................................................................................................... 1080 21 VISION/METHYLMERCURY/MONKEYS......................................................................................................................... 989 23 VISUAL SYSTEM/DEGENERATION/TRIPHENYL PHOSPHITE................................................................................................1339 22 VITAL FLUORESCENCE/MITOCHONDRIAL MEMBRANE POTENTIAL/GAP JUNCTIONS ..................................................139 11 VITAMIN A/CIPROFIBRATE/PEROXISOME PROLIFERATION.............................................................................. 1101 43 VITAMIN A DIET/LOCAL LYMPH NODE ASSAY/CONTACT HYPERSENSITIVITY............................................................. 1261 14 VITAMIN AND SELENIUM/OZONE TOXICITY/ANTIOXIDANT PROTECTION...................................................................... 632 78 VITAMIN B15/IN VIVO/IN VITRO/MUTAGENICITY...................................................................................................................846 47 VITAMIN D RECEPTOR/OSTEOCALCIN/LEAD.........................................................................................................................1183 49 VITAMIN E/HEART/PHENOXYL RADICAL ................................................................................................................................612 >1 VITAMIN E/OXIDATIVE INJURY/MTTOCHONDRIA.................................................................................................................. 622 45 VITAMIN E SUCCINATE/NITRIC OXIDE/SMOKELESS TOBACCO EXTRACT ...................................................................... 741 29 VITELLOGENIN/ANTIESTROGEN/TCDD ................................................................................................................................... 450 43 VOC/METABOLISM/CYTOCHROME P-450 .................................................................................................................................. 103 55 VOLATTLE/HCB/DERMAL ABSORPTION .................................................................................................................................. 1528 16 VOLATILE ORGANIC CHEMICALS/PERMEABIUTY CONSTANTS/PBPK MODELING........................................................ 670 58 VOLATILE ORGANIC COMPOUNDS/INHALATION/RISK ASSESSMENT............................................................................... 547 59 VOMITOXIN/SEX HORMONES/IGA NEPHROPATHY................................................................................... 1247 39 WARFARIN METOBUSM/CRYPRESERVATION, SLICES/HUMAN LIVER................................................................................37 22 WASP/PROTEIN STRUCTURE/VENOM ............................................................................................. 71 WATER PERMEATION BARRIER/BIS-(2-CHLOROETHYL) SULFIDE/PSEUDO-EPIDERMIS ...............................................343 73 WHITE OIL/MICROGRANULOMATA/HISTIOCYTOSIS ............................................................................................................ 688 71 WILDLIFE/BIOMARKERS/CYTOCHROME P-450 ...................................................................................................................... 1638 16 WILSON'S DISEASE/COPPER/METALLOTHIONEIN.................................................................................................................. 885 78 WR-2721/PLATINUM/BIOTRANSFORMATION ........................................................................................................................ 1707 38 WY 14,643/CARCINOGENESIS/PEROXISOME PROUFERATORS........................................................................................... 1172 33 X-RAY CONTRAST/IODINATED/NANOPARTICLE.................................................................................................................... 833 25 26 XENOIOTICS/RAT HEPATOCYTES/CYTOCHROME P-450 INDUCTION................................................................................. 708 66 XLENE/TOXICOKINETICS/ETHANOL......................................................................................................................................... 394 79 XM46/TERATOLOGY/PROPELLANT ...........................................................................................................................................585 39 XYLAZINE/CANINE/QEEG...........................................................................................................................................................1376 42 XYLAZINE/KETAMINE/PROPOFOL/VERAPAMIL...................................................................................................................... 805 52 Y-GLUTAMYLTRANSPEPTIDASE/NRK-49FCELL/ACIVICIN...................................................................................................640 YEAST/CADMIUM/PEROXISOME................................................................................................................................................. 873 YEAST/DNA REPAIR/CHROMIUM ............................................................................................................................................. 1006 YOLK SAC/METALLOTHIONEIN MRNA/URETHANE .............................................................................................................. 569 ZALCITABINE/HYDROCEPHALUS/BEHAVIOR.......................................................................................................................... 528 ZEBRA FISH/AFLATOXIN B i/METABOLISM..............................................................................................................................686 ZIDOVUDINEZAZT/PYRIMETHAMINE......................................................................................................................................... 529 15 ZINC/LEAD/NMDA RECEPTOR.....................................................................................................................................................251 74 ZINC/LIVER/METALLOTHIONEIN............................................................................................................................................... 886 98 ZINC/NERVE TERMINAL/METHYLMERCURY ........................................................................................................................ 1115 99 ZINC/DOPAMINE/DOPAMINE UPTAKE CARRIER ...................................................................................................................1130 94 [AH] GENE BATTERY/ALDEHYDE DEHYDROGENASE/TRANSCRIPTION FACTOR-BINDING SITES ............................ 1621 43 [AH] GENE BATTERY/UDP GLUCURONOSYLTRANSFERASE GENE/TRANSCRIPTION FACTOR-BINDING SITES ... 1622 68 [AH] GENE BATTERY/ALDEHYDE DEHYDROGENASE GENE/TRANSCRIPTION FACTOR-BINDING SITES ................ 1623 13 50 38 98 85 .05 ,08 86 557 511904 0280 511904 0281 l Society of Toxicology 1767 Business Center Drive, Suite 302 Reston, VA 22090-5332 Phone: (703) 438-3115 Fax: (703) 438-3113