Document qa58DwagD9G0pmazqRzj3Ye3x

RECEIVED C.CTD 9 ' . ' 7j . . t ~ - *M:r6 CLERK APPELLATE CT. FIFTH DIST. MT. VERNON, IL v- j On November 17, Hr. HcCltin end.I accompanied Dr, Suskind of the Kettering Laboratory to meeting at the Workmen's Compensation Commission in Charleston, Representing the Commission at this meeting were the Occupational Disease Eosrd composed of Drs. Brick. Biera, and Allff. Mr. Jack Canterbury. Legel Assisflat, IT. Barry Bess of the Oc- cupationel yiseATe- Division. ' \ Dr. Brick presented a copy of report by Dr. H. F. Smith end Dr. R.'E, Kelly addressed to Hr. Paul Halley dated 1950 and asked Dr. Suskind to comment on the^findings reported. Dr. Suskind said thet he is familiar with the rroort m d commented on the technique employed reporting that Drs. Adams, Spencer, end Irish \tfio originated ,,this technique using, the ears of rabbits have since abandoned it. Kettering Laboratory has attempted to duplicate some of their work find hfive found the same epithelial hyperplEsie and folliculitis as reported, but no acne was produced. Dr. Suskind states that it is not possible to pre-determine acnegenic properties of new compounds by this rabbit ear test. Dr. Brick inquired if there was any difference histochenically between acne vulgaris and chlor-acne. By use cf diagrams Dr. Suskind showed the comparison of the two types of acne and stated that histologically the two ere the same v/itn the exception that chlorr&cne lesions contain smerhst more free cholesterol. Dr. B i e m asked'What causes acne. ck&H2 8304iilg that materials in contact with the skin can produce chlor-scne, but the rossibilitv that it m:y be produced by other means is not ruled out. Dr. Biern asked whether skin reaction can be due to stress phenomena or from a fear overlay. Dr. Suskind said he would be afraid to hazard a guess, but work has been done at Cor nell Oniversity with young acne vulgaris patients subjected to interview stress, Measurement of sebum output showed a stress increase of as much as 400^ in acne cases only; in non-acne cases the increase was very slight. Whether this pertains to Monsanto chlor-acne cases is difficult to say. Dr. Brick inquired whether the materiel which the board saw being packaged during their plant tour was 2,4*5-T end was told that It was. He then asked whether that was the material which was given to Dr. Suskind for testing, and Dr. Suskind replied that that was one of the materials sub mitted. At this point Dr. Erick talked about tae air surveymade by the State* Department of Health, and when a copy of their report could not be found, he talked to the State In dus trial* Hygienist. He seemed distressed at the report that all samples had shown measurable amounts of 2,4* 5-T whereas he had been given the impression that there had been nothing discovered. He has requested the Industrial Hy gienist to furnish the board a copy of the survey report. At this point he insinuated that Monsanto could be more careful in handling the 2,4,5-T and spoke of seeing continuous automatic packaging operations at the duFont plant, ^r. Erick also inferred that much of the information concerning the chlor-acne problem had et one time or another been held secret from the'board. His impressions on these two matters did not appear to be reflected" in the other board members. Dr. Suskind tola briefly of the animal test done with 5^ solution of various materials from the 2,1,5-T process and with Hslorsx 1014. He retorted that there ras no reaction or change in any of the an i n 1 studies or in human subjects encored to tne same 5? concentration. Dr. Suskind then described the work using Ealorax 1014 ana recrystallized 2,4,5-T on animals and humans. He reported that no acne or skin manifestation bEQ been induced in any of the animals by eithero.f the mcteri&ls but that on human skin chlor-acne had been produced with the Halowax, but there was absolutely no reaction from the 2,1,5-T. G26743 The conference continued with conversation dealing rich the overall escects of the chlor-acne problem, end F:. Biern reed excerpts iron the transcript in the recent Dewey Carton hearing for Dr. Suskindfs benefit. The .neeting seemed to be appreciated by,the commissioner1s representatives, and it is believed that a favorable impression was created. Both John licClain and I feel "thet in view of Dr. Brick1s somewhat critical comments, we should prepare a fairly com prehensive story of the entire chlor-acne situation which should include not only the experimental work done at Mellon and Kettering but investigational work done in the plant in connection with the autoclave incident. We believe that this should be made available to the Occupational Disease Board together with copies of any reports which we heve that have not been made available to them. Such information can be given to them with the stipulation that it is for their evaluation only and is not to become part of the public records At the end of our conference at the commission offices, Dr. Suskind together with McClain and I discussed our problem with Mr. Paul Bowles and Mr. A.. G. Stone at their offices. Both Dr. Suskind and Mr* Stone feel that it would be wise for us to follow up on the Kettering recommendation that periodic air sampling be made In the 2,4* 5-T plant. Both McClain and I expressed doubt as to the value of information so obtained unless it be used to counter Dr. Hallora^s accusations. We discussed the findings of Dr. E. H. Nestmann concerning psychoneurosis in most of the employees he has examined for us. Mr. Stone is apprehensive as to the implications that may he drawn if this'is submitted as evidence. The attorneys and Dr. Suskind all read a paper which I obtained from Dr. Kestmann Concerning some of his evaluations on other patients using the Cornell Kedical Index, and Dr. Suskind suggested that he could hve an opinion on the vslue of this type of testing from Dr. v*. C. Hoss a psychiatrist at the Kettering labor?tory. I indie?red to him th?t we would be interested in such opinion. The future work which has been outlined for consideration at the'Kettering Laboratory was reviewed with the attorneys, and Ir. Stone made the point thet while distilling the phenol nay eliminate chlor-acne, it may not change the incidence of "Halloran's Disease." C8744 * iwn.inzo c+ 0 - I- V.r. Belles gave Dr. Suskind e complete set of the sunra of the legal ceses on rhlch evidence has been tccumulE date. LCW/fj 11-18-55 L. C. ^eger C2 8 7 4 5 *4 > 8 n 0 4 .'5i.l* .