Document qa227LEqKL13o8qdpqvvD4gG5
PLAINTIFF'S EXHIBIT
UC-3S90
March 30, 1979
MEMORANDUM TO: Asbestos Information Association/NA Legal Research Committee
FROM: Carey E. Gross Cadwalader, Wickersham & Taft
RE: Asbestos-Associated Disease: With Particular Reference to U.S. Shipyards, a Conference at the Mount Sinai Medical Center November 27-29, 19.78 __________
On November 27, 28 and 29, 1978 I attended a conference given at the Post-Graduate School of Medicine of the Mount Sinai School of Medicine in New York. The conference was a post-graduate course and was part of the 1973-1979 program of the University's Occupational Safety and Health Education Center, supported by the National Institute'for Occupational Safety and Health.
Approximately 300 people attended the conference, roughly broken down as follows: 40% doctors: 40% attorneys; and 20% workers and union members. The conference was well organized. I have summarized below some of the more Interesting discussions at the conference. All of the statements below were made by participants at the conference and do not necessarily reflect the opinions or beliefs of the writer. A complete tape recording of the proceedings is available from this office.
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-SUCC 008154
Further, many general statements about asbestos-related
diseases were made. Examples are: (.1) changes in normalcy of
x-rays
are
la--rgely
seen
after
long
latency
period
-
approximately -i
20 years; (2) one out of every five insulation workers in this
country dies of lung cancer; (3) historically, cancer has been seen much more in the lower lobes of the lungs and
linings instead of the non-peritoneum and higher in the lung
where those carcinomas normally occur; and (A) asbestos-related
cancers are often beyond the skill of a surgeon's knife (autopsy
photos suppprting this proposition were presented). Dr. Selikoff
stated that recent data shows a statistically significant increase in the appearance of carcinomas in the larynx, pharynx, and kidney in asbestos workers. The clinical latency period for these cancers appears to be roughly 15 to ho plus years.
Dr. Selikoff feels that the real problem with exposure to asbestos is cancer not asbestosis. A significant factor in this area is the end product use. Dr. Selikoff seems to feel that workers in companies manufacturing asbestos-containing end products have more health problems than those in the production and mining'segment of the industry.
Dr. Selikoff asserted that, in 195S, doctors began -to see mesothelioma cases in workers exposed to, only amosite.
This was suprising, since earlier medical opinion held that mesothelioma was caused by crysotile exposure. References were: Wagner-IST14,British Journal of Medicine, and 'oily ^'ev;house. He further asserted that brief exposure to asbestos , if excessive, nay be as hazardous as long term exposure to lower concentrations. Emphasis was placed on retorts that an
-3*UCC 008155
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-1- .
UCC 008156
Dr. Nicholson asserted that, in the shipbuilding industry, these associated with thermal insulation have the greatest chance of contracting asbestos-related diseases. The speaker emphasized importance of the total working environment, rather than just the particular trade. The prevalence of fibers and dust throughout the shipyard is, according to Dr. Nicholson, evidenced in abnormalities among all shipyard workers. Guards without previous yard jobs and draftsmen without any experience in the yards have been diagnosed as having some of the asbestosrelated diseases. It is estimated that approximately 4-1/2 million different individuals were employed in shipyards during World War II.
Dr. Selikoff discussed the fact that researchers have seen in utero transfer of asbestos exposure In animals but not in humans. He also asserted that children of workers who contract asbestos-related diseases show symptoms 20-30 years after birtn. The assumption is tnat tney Inhaled fibers in their home, probably carried by their father's clothing or hair or body, not from in utero exposure. Dr. Selikoff noted that exposure cannot really be stopped once a single exposure has occurred because the Inhaled fibers continue to expose the lungs and the lung lining.
The speakers pointed out that, for laymen reading some cf the epidemiological data, it is important to understand the "healthy worker effect". In general, the best comparison for all studies is the U.S. population data. But for the first
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-B-
UCC 008158
The .very small fibers do not fall rapidly due to other atoms
and molecules moving in the atmosphere. These other particles
push the small asbestos fibers around - often pushing them upwards.
In a vacuum, the smallest fibers would settle - but this is not
so in the atmosphere. Therefore, some fibers may never settle
regardless of gravity. This leads to an increased duration
of possible exposure to the fibers.
Dr. Langer asserted that there are no known safe
exposure levels to asbestos. However, he believes that, as
dose exposures decrease, there should be a decrease.in the
incidence of the various diseases. He said that there is no
known exposure standard in the United States to prevent cancers.
As a result, the industries and sciences work on a regulatory
system trying to minimize exposure and possible related diseases.
Dr. Nicholson discussed difficulties with early dust
measurements. The basic problems noted were:
1. Few counts ware done;
2. Those that were done did not use current techniques;
3. All particles (mppcf) were counted rather than
only .-fibers; and
4:_, Conversion factors were uncertain...
*
----- -
Mr. Michael 'food, Director of Safety and Communications, International Brotherhood of Boiler Makers, read from a Chicago Tribune newspaper article: "The federal government has the heaviest of responsibilities in finding solutions to problems of millions of workers exposed." Mr. Wood then asserted that
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___________________ ______ :___UGG 008-W0--
-B-
---------------- ----- -----------"
what> was occurring in those exposed to coal dust and some silica. The classifications described nodules, but when 'the nedical profession began seeing asbestcsis films they could not use the same descriptions for two reasons. First, there were no nodules. Second, asbestos-related problems were apparent not only in the lungs, but also in the pleura, and the initial classification slides did nor relate to non-lung problems.
Dr. Selikoff reiterated that it is important to remember that there is a much greater amount of pathology in the lungs than can be seen on x-rays. X-rays always under estimate what is there. Because cf this, a whole new set of. standards and classifications were developed regarding asbestos and asbestos-related diseases and filns showing each of_these. The result is a new (1978) classification system. This will include a proposed set of standard films so that anyone looking at the films will know exactly what is meant by the various classifications. xn ouher words. doctors ca.. vein. are th* films of their patients to the standard films that come with the classification packs * There is also a proposal that there be a set of end-category films. These films would show both ends of each category so that a particular classification will include film from the middle (.or average) of that category and both extremes of that category.
Dr. Rabin asserted that mesctheiiorr.a of the pleura is rarely encountered among people without any asbestos exposure. He stated that autopsies will reveal less than one out cf 10,000
_o-/ _ UCC 008161
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-:iUCC 008162
4. Carcinoma is increasingly common without pulmonary
asbestosis; and 5- It is difficult to differentiate between pleural
carcinoma, pleural rr.etastases and mesothelioma. There appears to be a possibility of using, nuclear medicine in determining primary bronchogenic carcinomas. A gallium scan may be able to ceTect some of the fibers in the lung tissues. Those patients with malignant mesothelioma would be detected by gallium scanning and differentiated frcm these with benign pleural involvement. Dr. Rabin stated that lung cancer is eight times as great in those exposed to asbestos as in the general V.S. population. Ke also asserted That blocd-gas studies are unlikely to help diagnose asbestosis. Apparently it is common to have negative x-rays although various pulmonary problems exist. It is Dr. Rabin's view chat asbestosis ar.i carcinomas have no dose-respense relacionship to one another -- each has their awn dose-respcr.se curve. Diagnostic thoracotomies are not recommended by Dr. Rabin. He noted that there have been three deaths due to diagnostic thoracotomies at Mt. Sinai. There appears to be a low resistence to oost-ohoracotomy infection.
According to Dr. Churg, mesothelioma is much less common than the lung cancers out much mere soecific. raroirema
0
of the pleura is lung parenchyma surrounded by mesothelioma. Histologically, mesothelioma may look very similar to carcinoma of the pleura. Any tumor than gets ir.tc The pleura will grow
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-SI-
UCC 008164
15 of a man's life is lost if he becomes an asbestos worker. He did note that it is important to remember that we are Balking strictly averages and that the results are different for every worker. The passage of time from onset of exposure is critical. It Is important to remember that for research purposes a study period of less than 20-25 years is not as significant as the period after 30 years.
Dri. Selikoff continued by stating that there is a sharp dose-response relationship for lung cancer - the longer a worker has worked with asbestos, the more likely he is to get lung cancer - but again the latency period is crucial. The tissue burden continues to affect with no further exposure other than the initial exposure which can be one month, one year, even one week. The smaller the initial dose, the longer the induction period (dose-induction period). These were said to be the biological parameters that must be taken into consideration.
One segment of the conference was directed toward , discussing "family contact diseases." Dr. Anderson explained tha this relates to children and 'women exposed to workers who were occupationally exposed to asbestos. It Is believed that the dust and fibers brought back into the home by the worker -were carried on their bodies, in their hair and on their work clothes. There is a relative risk factor of ten'for women with mesothelioma. This means that a 'woman with mesothelioma Is ten times as likely to live (or have lived) In a home with an asbestos worker than, a woman in the control group.
-13UCC 008165
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UCC 008166
than $10,000. According to Mr. Paul Gillenwater the earliest firm
of occupational -diseases are set apart from accidental injuries for two reasons:(1) the disease is not accidental but is usually expected; and (2) the disease has developed over a long period of time versus a sudden onset (like an accident).
Compensable disability can also be divided into two categories -- a disability of a medical or physical nature and a de facto inability to earn wages. The two types usually occur simultaneously, but they can occur independently.
There are four classes of disability: temporary-total; temporary-partial; permanent-total; and permanent-partial. A tore detailed discussion of these four classes of disability is contained in the American Medical Association "guide" to permanent disability. It is important to remember that in determining disability the focus is not on the loss of earning capacity but dn the cause cf the lots cf earning capacity (i.e., is it 'occupational? 1. As cf October 1, 1978 the maximum rate of compensation was $395 car week.
*
Mr. Matthew Shafr.er revealed that a ceterr.ir.ation of dis ability is not only dependent on a diagnosis but also on age, education, industrial history.and available employment which the claimant can obtain after injury. Further, disability in a legal sense does not become permanent until it reaches maximum medical improvement. This determination is made by ar. acministrativ law judge. Mr. Shafner said, that written medical reports may not be introduced into evidence in disability hearings and in asbestosis cases it is generally desirable - and often necessary -
-15UCC 008167
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UT$^0D8168
_____ ___
awards. It is hard to obtain total compensation through social
*
security. Mr. Gene Locks posed the following crucial questions for
determining legal points In workmen's compensation claims; Does a disease exist at a sub-clinical stage? or only when it Is detectable at radiographic stages? or when pulmonary function changes become evident?
With respect to the varying statutes of limitation, in Mr. Henderson's opinion, the time when the cause of action accrues could be: (1) when the plaintiff suffers harm; (2) when the plaintiff becomes aware of the disease process; (.3) when the plaintiff recognizes the causual realtionship between exposure and the disease; or (4) the defendant's date of duty (last exposure date).
Mr. Ronald Motley asserted that a good radiologist should be able to distinguish between fibrosis caused by smoking and fibrosis caused by asbestos exposure. He also stated that asbestos fibers and cigarette smoking act independently and either can'cause lung cancer. He pointed out that a non-smoking asbestos worker has a five times greater chance of contracting lung cancer then the general population.
Mr. Roy Stelnfurth stated that compensation claims are usually too late or inadequate to halt the chain of "collateral" eyents that occur when a worker has contracted an occupational disease. Some of those events are depression, break up of the family, depletion of savings, loss of wages, and the like. He
-17UCC 008169
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UCC 008170
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