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The Registry of Toxic Effects of Chemical Substances (RTECS) Page 1 of 13 The Registry of Toxic Effects of Chemical Substances Asbestos, chrysotile RTECS #: CI6478500 CAS #: 12001-29-5 PLAINTIFF'S EXHIBIT SA-494 UPDATE: July 2000 MW: N/R MF: H404Si-l/2H20*3/2Mg NOTE: TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY. TABLE OF CONTENTS: 1. SYNONYMS: 2. MUTATION DATA: 3. TUMORIGENIC DATA: 4. ACUTE TOXICITY DATA: 5. OTHER MULTIPLE DOSE DATA: 6. REVIEWS: 7. STANDARDS AND REGULATIONS: 8. NIOSH DOCUMENTATION AND SURVEILLANCE: 9. STATUS IN FEDERAL AGENCIES: 10. REFERENCES: http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) SYNONYMS: 1. 7-45 Asbestos 2. Asbestos (ACGIH) 3. AvibestC 4. Calidria RG 100 5. Calidria RG 144 6. Calidria RG 600 7. Cassiar AK 8. Chrysotile asbestos 9. Chrysotile asbestos (ACGIH) 10. Hooker No. 1 chrysotile asbestos 11. K6-30 12. Metaxite 13. NCI C61223A 14. Plastibest 20 15. 5R04 16. RG 600 17. Serpentine chrysotile 18. Sylodex 19. White asbestos Page 2 of 13 SKIN AND EYE IRRITATION DATA AND REFERENCES: ROUTE/ ORGANISM N/R DOSE EFFECT N/R N/R REFERENCE N/R MUTATION DATA AND REFERENCES: SYSTEM TEST cytogenetic analysis cytogenetic analysis cytogenetic analysis cytogenetic analysis cytogenetic analysis cytogenetic analysis cytogenetic analysis ROUTE/ ORGANISM/ TISSUE hamster lung DOSE 10 mg/L hamster embryo 100 pg/L hamster ovary 10 mg/L human lymphocyte 10 mg/L ' intraperitoneal mouse intraperitoneal rat rat other cell types 50 mg/kg 100 mg/kg 2 mg/L REFERENCE CRNGDP 8,553,1987 ENVRAL 10,165,1975 CSHCAL 4,941,1977 MUREAV 265,245,1992 MUREAV 319,303,1993 CNREA8 48,6455,1988 NASGEJ 3.511,1985 http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 3 of 13 cytogenetic analysis DNA inhibition unscheduled DNA synthesis intratracheal rat hamster lung human lung unscheduled DNA synthesis rat other cell types micronucleus test hamster embryo micronucleus test hamster lung mutation in mammalian somatic cells hamster lung morphological transform hamster embryo morphological transform mouse other cell types morphological transform rat other cell types other mutation test systems hamster embryo other mutation test systems hamster ovary other mutation test systems human fibroblast other mutation test systems intratracheal rat sister chromatid exchange hamster ovary sex chromosome loss and nondisjunction sex chromosome loss and nondisjunction sex chromosome loss and nondisjunction ........ r sex chromosome loss and nondisjunction oral Drosophila melanogaster hamster embryo hamster lung intraperitoneal rat 2,900 gm/L 62 mg/L 10 mg/L 4 pg/cm2 500 ng/cm2/48 hour 3,297 pg/L 10 mg/L 250 ng/cm2 ENVRAL 57,175,1992 TIVTEO 1,71,1987 JEPOEC 6 (5/6), 169,1986 MUREAV 241,361,1990 CNREA8 44,5017,1984 MUREAV 320,253,1994 MUREAV 68,265,1979 PAACA3 24,96,1983 10 mg/L CSHCAL 4.941.1977 400 ng/cm2 1 mg/L 10 mg/L 10 mg/L 2,900 gm/L 100 pg/L CRNGDP 6,523,1985 ENVRAL 10,165,1975 MUREAV 116,369,1983 MUREAV 116,369,1983 ENVRAL 57,175,1992 ENVRAL 24,325,1981 5 gm/L MUREAV 261,9,1991 500 ng/cm2/48 CNREA8 hour 44,5017,1984 40 mg/L CRNGDP 8.553.1987 100 mg/kg CNREA8 48,6455,1988 http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 4 of 13 REPRODUCTIVE EFFECTS DATA AND REFERENCES: ROUTE/ ORGANISM N/R DOSE EFFECT N/R N/R REFERENCE N/R TUMORIGENIC DATA AND REFERENCES: ROUTE/ ORGANISM DOSE EFFECT REFERENCE inhalation hamster lowest published toxic concentration: 23 mg/m3/7 hour/47 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors ENVRAL 10,368,1975 inhalation man inhalation rat inhalation rat lowest published toxic concentration: 400 million particles per cubic foot/1 yearcontinuous lowest published toxic concentration: 11 mg/m3/26 week- intermittent toxic concentration (other than lowest) : 12 mg/m /13 weekintermittent Endocrine: Adrenal cortex tumors Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) AEHLAU 28,61,1974 Lung, Thorax, or Respiration: Tumors Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors BJCAAI 29,252,1974 Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors RRCRBU 39,37,1972 http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 5 of 13 inhalation rat inhalation rat implant rat intrapleural rat intrapleural rat intrapleural rat intrapleural rat intrapleural rat toxic concentration (other than lowest): 10 mg/m3/52 weekcontinuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors IAPUDO 30,285,1980 toxic concentration (other than lowest) : 11 mg/m3/8 hour/26 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors IAPUDO 30,363,1980 lowest published toxic dose: 200 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application IARCCD 8,289,1973 lowest published toxic dose: 100 mg/kg Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors BJCAAI 23,567,1969 lowest published toxic dose: 300 mg/kg/12 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors VOONAW 20 (4),47,1974 toxic dose : 90 mg/kg Tumorigenic: Neoplastic by RTECS criteria JSOMBS Tumorigenic: Tumors at site 29,20,1979 of application toxic dose : 200 mg/kg Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma JNCIAM 48,797,1972 toxic dose : 120 mg/kg/2 weekintermittent Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application CALEDO 17,313,1983 http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 6 of 13 intraperitoneal lowest published toxic dose: 200 hamster mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Other changes IAPUDO 30,337,1980 intraperitoneal lowest published toxic dose: 80 mouse mg/kg Tumorigenic: Carcinogenic by RTECS criteria ENVRAL Tumorigenic: Tumors at site 35,277,1984 of application intraperitoneal mouse toxic dose : 400 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria ENVRAL 27,433,1982 Gastrointestinal: Tumors intraperitoneal lowest published toxic dose: 9 rat mg/kg Tumorigenic: Carcinogenic by RTECS criteria ZHPMAT Tumorigenic: Tumors at site 162,467,1976 of application intraperitoneal rat toxic dose : 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria ENVRAL 4,496,1971 Tumorigenic: Tumors at site of application intraperitoneal rat toxic dose : 28 mg/kg Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors NATWAY 59,318,1972 intraperitoneal lowest published toxic dose: 25 rabbit mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Other changes IAPUDO 30,337,1980 intratracheal toxic dose : 48 mg/kg/6 week- hamster intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors IAPUDO 30,305,1980 http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 7 of 13 intratracheal mouse lowest published toxic dose: 200 mg/kg Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors PAACA3 15,6,1974 intratracheal rat lowest published toxic dose: 13 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Bronchogenic carcinoma ENVRAL 21,63,1980 multiple hamster lowest published toxic dose: 240 gm/kg/35 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Facilitates action of known carcinogens ANYAA9 132,456,1965 Tumorigenic: Carcinogenic by RTECS criteria oral rat lowest published toxic dose: 7,100 mg/kg/39 weekcontinuous Liver: Tumors ARGEAR 46,437,1976 Kidney, Ureter, and Bladder: Kidney tumors Tumorigenic: Neoplastic by RTECS criteria subcutaneous lowest published toxic dose: 2,400 mg/kg/13 week- mouse intermittent Lung, Thorax, or Respiration: Tumors FCTXAV 6,566,1968 Tumorigenic: Tumors at site of application ACUTE TOXICITY DATA AND REFERENCES: ROUTE/ ORGANISM DOSE EFFECT REFERENCE http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 8 of 13 inhalation human lowest published toxic concentration: 2.8 fiber/cubic centimeter/5 year Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Lung, Thorax, or Respiration: ENVRAL Cough 23,292,1980 intraperitoneal lowest published lethal dose: rat , 300 mg/kg Lung, Thorax, or Respiration: Dyspnea Behavioral: Change in motor activity (specific assay) Gastrointestinal: Hypermotility, diarrhea AJPAA4 70,291,1973 Gastrointestinal: Peritonitis OTHER MULTIPLE DOSE DATA AND REFERENCES: ROUTE/ ORGANISM DOSE EFFECT REFERENCE inhalation hamster inhalation rat lowest published toxic concentration: 30 mg/m16 hour/78 week- intermittent lowest published toxic *3 concentration: 8,210 jig/m /6 hour/20 day- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) INHTE5 Lung, Thorax, or Respiration: 7,503,1995 Changes in lung weight Lung, Thorax, or Respiration: TXAPA9 Fibrosis (interstitial) 137,67,1996 Gastrointestinal: Other changes oral lowest published toxic dose: 10,867 mg/kg/78 week- Kidney, Ureter, and Bladder: Other changes in urine TOLED5 rat continuous composition 39,205,1987 Biochemical: Metabolism (intermediary): Other carbohydrates http ://www. cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) REVIEWS: Page 9 of 13 ORGANIZATION STANDARD REFERENCE American Conference of Governmental Industrial Hygienists (ACGEH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,1999 American Conference of Governmental time-weighted average 0.2 Industrial Hygienists (ACGEH) Threshold Limit DTLVS* Value mg/m3 f/cubic centimeter (f) TLV/BEI,1999 International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 2,17,1973 International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 2,17,1973 International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 14,11,1977 International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 14,11,1977 International Agency for Research on Cancer Group 1 (IARC) Cancer Review IMSUDL 7,106,1987 TOXICOLOGY REVIEW 3 IBYAP,93,1974 STANDARDS AND REGULATIONS: ORGANIZATION STANDARD REFERENCE Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 fiber/cubic centimeter (fiber DTLWS* 3.33.1973 > 5 um) Occupational Safety and Health Administration (OSHA)........: ' Occupational Exposure Limit - AUSTRIA cancer hazard Carcinogen, JAN1999 CFRGBR 29,1910.1001,1987 Occupational Exposure Limit - FRANCE VME 0.6 fiber/ml, continuous 1 Carcinogen, JAN 1999 Occupational Exposure Limit - NORWAY time-weighted average 0.1 fiber/cm5, JAN1999 http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 10 of 13 Occupational Exposure Limit - SWEDEN time-weighted average 0.2 fiber/ml, Carcinogen, JAN1999 Occupational Exposure Limit SWITZERLAND MAK- week 0.25 fiber/ml. Carcinogen, JAN1999 Occupational Exposure Limit - UNITED KINGDOM LTEL 0.5 fiber/ml/4 hour, JAN1993 Occupational Exposure Limit - UNITED KINGDOM LTEL 1.5 fiber/ml/10 hour, JAN1993 American Conference of Governmental Industrial Occupational Exposure Limit IN Hygienists (ACGIH) Threshold Limit Value; ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA time-weighted average 0.2 mg/m3 f/cubic centimeter (f> Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m? f/cubic centimeter (f) NIOSH DOCUMENTATION AND SURVEILLANCE: ORGANIZATION STANDARD or SURVEY REFERENCE National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ASBESTOS-air National Occupational Exposure Survey 1983 100 minute time-weighted average 0.1 fiber/cubic centimeter in a 400L air NIOSH* DHHS sample #92-100,1992 National Occupational Exposure Survey 1983: Hazard Code: T1575; Number of Industries 45; Total Number of Facilities 5,924; Number of Occupations 48; Total Number of Employees Exposed 92,033; Total Number of Female Employees Exposed 13,262 http ://www. cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) STATUS IN FEDERAL AGENCIES: Page 11 of 13 ORGANIZATION REFERENCE EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat EPA GENETOX PROGRAM 1988, Negative: TRP reversion EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000 NIOSH Analytical Method, 1994: Asbestos (bulk) by PLM, 9002; by PCM, 7400; by TEM, 7402 NIOSH Analytical Method, 1994: Asbestos, chrysotile by XRD, 9000 NTP Carcinogenesis Studies (feed):some evidence:rat NTPTR* NTPTR-295,1985 NTP Carcinogenesis Studies (feed);no evidence:hamster NTPTR* NTPTR-246,1990 NTP 9th Report on Carcinogens, 2000:Known to be human carcinogen REFERENCES: CODEN REFERENCE 3 IBYAP / AEHLAU "Experimental Lung Cancer: Carcinogenesis and Bioassays, International Symposium, 1974," Karbe, E., and J.F. Park, eds., Springer-Verlag New York, Inc., 1974 Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.l- 1960- AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MOD 21740) V.l- 1925- ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., NewYork, NY 10021) V.l- 1877- ARGEAR Archiv flier Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.l- 1949- BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.l- 1947- CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.l- 1975- http ://www. cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 12 of 13 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.l-1941- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.l- 1980- CSHCAL Cold Spring Harbor Conferences on Cell Proliferation. (Cold Spring Harbor, NY) V.l-10, 1974-83. DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.l- 1967- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.l-19,1963-81. For publisher information, see FCTOD7. IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979- IARCCD IARC Scientific Publications. (Geneva, Switzerland) No. 1-26, 1971-78. For publisher information, see IAPUDO. IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO PublicationsCentreUSA, 49 Sheridan Ave., Albany, NY 12210) V.l-1972- IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.l- 1979- INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor & Francis Inc., 1900 Frost Rd, Suite 101, Bristol, PA 19007) V.l- 1989- JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.l-60, 1940-78. For publisher information, see JJIND8. JSOMBS Journal of the Society of Occupational Medicine. (John Wright & Sons, Ltd., Techno House, Redcliffe Way, Bristol BSl 6NX, UK) V.23- 1973- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.l-r 1964- NASGEJ NATO ASI Series, Series G: Ecological Sciences. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No. 1- 1983- NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.l-1913- http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002 The Registry of Toxic Effects of Chemical Substances (RTECS) Page 13 of 13 NIOSH* National Institute for Occupational Safety and Health, U.S. Dept, of Health, Education, and Welfare, Reports and Memoranda. NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.l- 1954- RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.l- 1965- TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.l- 1987- TOLED5 Toxicology Letters. (Elsevier Science Pub. B. V., POB 211, 1000 AE Amsterdam, Netherlands) V.l- 1977- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)V.l- 1959- Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. YOONAW (V/OMezhdunarodnayaKniga, 113095 Moscow, USSR) V.l-10, 1928-37; V.l- 1955- ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, ReiheB: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V. 155-169, 1971-1979. For publisher information, see ZAOMDC. RTECS Compound Description: Tumorigen Mutagen Human Data Natural Product ALT CAS #: 12426-98-1 ALT CAS #: 61076-97-9 http://www.cdc.gov/niosh/rtecs/ci62daa4.html 9/14/2002