Document q5JEmYGkg80od4eaYV5pvqGE
AR226-2756
FOR DU FONT USE ONLY
Coppiieesf c^o^n H^B--------------!
E. I. du FPonnet dae Nemoure and Company
Haakeill Laboratory for Toxicology and Industrial Medicine
Elkton Roiad, Newark, Delaware 19711
HASKELL LABORATORY REPORT NO. 783-80 ||BIHBHH| \
Study Iniciat6d/Coapl6d 6/5/80 - 8/28/80
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1-^cSB^SSpt^^ -*
HaBkall Lab
ORAL LD5Q TEST IN RATS
) Procedure! The teat material, as a up'enion in corn oil, was adlaict;ered
by incragactric incubation ia bia](JliD doa to 5 groups of 1U young adult
^
ChA-CDe male racs. A Range-Pibding S[<:udy uting 1 rat/dote level w&c conducted
co daceroino cbe initial doic layel', {'or cbie U>30 Cc. (1) The surviving
^
raca wre weighed and obaerved duTi'ftg" a 24-2^ day iecovery period and then
sacrificed. The LDSO value was calculaced froa the aorcalicy data using the
method of D J. ?inaay.*'
:
AeaulU!
OoRe
^ae/icg?
Average Body
Weight (^)
1'
i
Sucpetaion
W
Average DOM Ctti)
Mortality Ratio
LD50***
250
259
200
248
150
260
100
253
lt5
4.31
10/10
96 ng/kg
1.2
4.13
10/10
1*0
3.91
10/10
'
0.6
4.22
3/10
50
245
0<3
4.09
1/10
|-gl
Company Sanilteed. Does nol oont.1" TSCt
Clinical Signs;
250 og/kg
Stained and wee perinaal area, stained face, diarrhea, weakness, lethargy and continual weight loss. All deaths occurred within 5 days afcer dosing.
200 ing/kg
Scained body, wet perineal area, diarrhea, piloereccion, wanness, lethargy and continual weight loss. All deaths occurred within 6 day after dosing.
150 fflg/kg
Stained body, wet perinaal area, diarrhea, humped pasture, ayes half-closed, weakness, lethargy and continual weight loea. All deaths occurred within 12 days after dosing.
1UO ag/kg
Stained body, wet yg half-cloBed,
weight losa All
dosing
perineal area, diarrhea, humped posture, piloereccion, alopecia, weakness and severe deaths occurred within l6 days after
50 Bg/kg
Seained aad wet perineal area, alopecia and moderate co severe weight Iocs. Death occurred on Ach day after dosing.
orally too young adult Ch6-CD o&le ractasltsa single doses, its LD50 is 96 ag/kg of body Wight. Clinical Bign observed &c oe dos levels included;
stained body, wee perineal area, diarrhea, weakness^ lethargy and weight lows. All deaths occurred within 16 days ftr dosing.
These animals were hald f^r a prolonged recovery period due to deaths occurring as long aa 16 days after troacaent,
** Finney, D. J., Probie Anfllysit. 3rd ed., l97l, Cambridge University Press.
*** 95X Confidence Limits!
Lower:
Upper: Slope:
72 mg/kg 116 og/kg
6.7
(1) The Range-Finding Study-was run from 200-2,250 gig/kg with death occuring
at all dose level? except 200 mg/kg.
2 -
Company Sanitized. Does not contain TSCA CB^
^P"^ by:
//^^^ X^v.
Lon ninck.la
Technician
Approved by; ^^ip^-i^^-'y,fe^y^^Li
Cerald Li. Kannafdy Chief, Acufce InvaBtigac|Lons Section
LHsjrg
ScuUy Dtrtccor; 0. L. Dwhiall
OaCs Isauad:
Ocsohar
I ,
1980
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lBpor^<o^83-8^3
3 -
Company Sanitized. Does not contain TSCA CBi