Document q3eVZKp6LebjQvqMLJwxQRRyq

4taAdetui I1 \ KHUT3J 07 KKaSIK HLD JUDAEI 31, 1747 If WBTOiL HUKJHAXTIHX fO 2*31T1 ID DUCUBS 2XP0S3 07 Dfc. AW. IOILA XX. fHl STAIUI 07 DLLTCKAflXOUS mfH DOIT IXPELDQEITS, IX SKXSXXIID 3 HI X3QXX7 HtEF TO fXX 8AJUULLC LAbOIiTCg Pnmt vers: A. J Lsm . V. Lm A* 1* Tisher A. 8. llmkil 7. Xrw* 0. V. like 7, X* Armstrong H*. M. Jabi <7* 3U Eeailiea J P Vo4jLTd Xr* Veodard erred as chairman rf the masting. PLAINTIFFS EXHIBIT iw-ooi Ihe meeting ni called te order ikartl/ after 2 ?*JU In A3. Tisher'e effiee. Va agenda had, baas prepared, the meeting primarily haring bean call ad far the purpoaa af hearing a report V Avd* J Leman, af kha Metropolitan Ufa Insurance Cospaay, saanarlxiag tha. present status af kha experiment vith diatemmeeo'us earth at kha Saranao Laberatory. Tha chairmen dispensed vith a rarlav af kha industrial hygiene problems ak Lompoc vhlah had been eararad la a previous meeting, and Invited Dr* Lana ko girt a rapert of kha information vhlah ha had gakharad oa his recent krlp ka kha Saranac Laboratory. togrtjfe.l>r. Lqit ooomon Dr. Lanza raportad that during hla roeask rloit at Saranac ha had had aeeooa ko all tha memoranda and notes loft by tha lata Dr* Gardner, and ha had talked with practically everybody there vho vu concerned vith kha veik. Tortnnately, Dr* Gardner had a very capable aecretary, but, unfortunately, aha had verkod for hla only approximately one year before ha died. Vhile her own knovledge af kha axparlacnko did nak go hack boyond that year, eho did haro at her finger tips everything that had happened during the year and the van also able to provide from tha files substantial information in connection vith earlier ezperiasnte vith asbestos. Xrldently, Dr* Gardner had planned ka issue a comprehensive article on Aeboeteot Iks effect on an1vale, its effect on human beings; as vail as related research problems, prodmetlom problems, kha control of duet lm different kinds af Industrial plants, ete. He had practieally finished tha part of hla rapert dealing vith tha offsot af asbestos dnat on human beings, and had annotated tha reek af It, making rough nates and comments. ' Dr* Lanzm vrots ta Dr. Kenneth Lynch mt the Medical School in Charleston, 3*0., vho had beta assoolatod vith tha lata Dr* Gardner and hlaself on a lot of tha early vozfc on asbestos cases, informed him of tha situation ms he had found it at Saranac, and, ae far as being able to provide smooth copies * vns concerned, told him it had been arranged te hare the late Dr. Gardner's secretary make the necessary ooples and fonrard them* (Incidentally, the Trustees of tha Trudecn S&naterlum mad Toundmtiom authorized Dr. Lanza to offer Dr. Lynch a foe of IHX5 to mt t>o .i-**t -3- Exhibi Sr. Laama tea infarmed Sr. l/neh that the material rill V) fimriWL ta him u m u It la 1* ahape *e that ha rill sat her# ha hr7 ha deaiphar the Lata Sr, Gardner'* hamdvritirg: ami ha haa reeatred a reply ha tha effect that, after Sr, Lynch tea had am eppertunity \a agamies tha aataxial, ha rill determine rhathax lh la peaalhle ha fit it tegsther im publishable farm. ; Sr. tens* plana ta laara am a trip ha tha Meet tSaaa.h aheat tha flrah f fahnarf ate tea dTisad Sr* Lyxeh that ha rill arrange if paaaihla ta hare tha maharlal uat ta him hafar that tlma, hat, ateuld it amt ha mi/ than, it rill ha tronamlttad aarsrttelasa during Sr, Lamia1 a ahaaaee. Sr, Lamia Bail ha rauld keep im touch rlth J-M aheut this, ami alaa about vtet Sr, Lymeh camelode a ha can la rlth tha aat trial, la atat ad that thara raa fait a a lat of aat trial cad at laast tha basic part--that dealing rlth tha affeet of aahaaiaa duet am Yr*~+* hala^s--Msti ta ha falrl/ complete aad ha bellerad it venali aaha a aatiafeatary rrpert, Hr. T. Brava inquired as ta vhather Sr, terns* tkaught Sr, Lymah vould attempt ta produce tha entire work carering 'asbestos* rhieh Sr. Gardner had had 1m alad, ar rhathar ha evald oonertrete ami/ am tha part dealing rlth tha effaot af asbestos da.it am httuan boimgs; ta rhieh Sr, Lean. replied ha did aat kmar, almaa Sr, Lynch roald mat daalda about it rmtll after ha had raeairod tha mataa -- tet ha raa hoping that all af it could b put imto mi aort af steps. Mr* Irarm raferrod ta tha tavta rlth aahaatoa rhieh Hr. fehmel, af tha Matropalftma Lift Insurance Oa.i had oamdnctod at tha Mimaa soma tlma ago, ami. saggrstod that Sr* Lynch night maka maa af tha lmfarmatlom ahtaimad fro* tha aa taat, im aanmeotien rlth tha rexk rhieh ha la about ta undertake. Sr* temca agreed that this might ha dama. Mr. Ilaher raautad that tha campamy haa a dafimita Jab ta da im Camada ta affaat tha affaeta af a lat af prepagaadlilng that haa haam dama im relation ta tha harmful affaat a af asbestos dust, amd ha exprataad tha apimloa that a rapart, ^prepared by Sr, lynch .atoms tha lima a outlined, mould ha of mat a rial halp ta tha oampau/. Beferring ta Sr, Lynch' statement to Sr* Lamsa that ha mould ita if tha mat trial aamt him oould ha put imt a 'publishable* farm, Mr, T, Brer* oallad attention to a stipulation im our arrangement rlth tha Saranac Lahorater/ rhieh provided that thara mould ha ma publication. af tha raaulta af experiments without aur consent. Ha aaid, if it daaa torm out to ha tha aort of rapart va mould ha glad ta ter# published, ha hapad Sr, L/mch vould not include am/ objectionable mat trial from our point af riav, aa, far azampla, cm/ rela tion hatrasa aahaatoa duat amd cancer, such ma tha reference rhieh Sr, Gardner had mada to this in hit mono graph. Ha added, that tram though tha report eemtaimad torn# material that vaan't too farorahla, from our poimt of Tiav, vo at 111 mould prohahl/ ha rilling ta hart it puhliahad haeauaa af tha hamaflt ta ha gaimad from tha balance af tha rapart. Sr. Lamia matured Mr. Irarm that tha imtomt af tha at&tamaat im question raa that am/ raport praparad h/ Sr, L/meh vould firrt ha submitted to Johaa-Kaarille hafara halms puhliahad alaavhara, / Hr, fitter comaamt ed that ha wouldn't rant to aaa am/ raport om aahaatoa 'one theueaad parcamt perfect". Ha nentioned tha eight duet cat a a rhieh had haam filed againat tha eospam/ at iabeatos during tha paat tvo or three /ears, all of rhieh had haem eummaril/ throve out, and oomaamtad upom tha feet that thla faick aetlem rith raapoot to mil eight of tha eaaaa had had aa adverse affaet vhara community opimiom vaa oomeermad, aa tha re 00011997action had beam mane toe good. Mr. VoodarA remarked that tha mimth eaaa, hovarer, had turned out quite differently, time# it daralopad that tha individual Involved vaa reported to hara had lung changes and pathological change*, vhlch had not been found in tha other tight. ----------------- ........................... ........................ Exhibit Sr. Lam -- mU U< itinntloa that ary. rny fsw iaathi srer hara resulted from dsbesteais aa uk. 2* referral to the large asaWr of mmi which he had felloe-od through. yeare age, amd which allegedly had >*i censed by the inhalet Isa ef aoVrrtes teat, M la all if which ha hal fmi the lsilrliuli had affected V rther diseases, --ah as cancer, Bright's disease, tuberculosis, ala*. end aaaa had HU frs* dsboatssls uncomplicated "kf ecus thing tlM. Getting bock ti the progress if the experiments at the Ianu lobe rotcry, ha said the verfc la going slang la gaol shape am rrerybedgr1 s projects, sa far aa the ground rt la concerned. Baa technician whs haa eharge sf the dusting of amiaala la amtremsly capable ami. probably the squal of anybody to ha found la the Unit*4. Stataa. There haa Vasa aa lt-up la the darting sf the amiaala, ami after the experiments hare Warn m far the required length af time, ths amimals ars hill si ui thslr regains sectioned far tarts, Herrrer, the serrlces sf am expert pathologist ars maestaary ts lmt erpret the flail age, sad that takes 11ms. Sr. Lanza palA a glowing tribute ts Sr, X* X, Packard, whs la mow lot lag Director sf the Termmdatlea, wham he described aa 'a rsry same, aelld individual whs Tmerer rocks ths beat1-. Thssy had had a rsry cwrpetsnt pathologist at Saraaac by ths mams ofBonrald. Dor lag ths war he had gome late ths serrlca amd had flaally emerged aa head sf research fer ths Iry. Dr. Lamia understood that he was go lag to become a psraaasmt nsnborof ths Xatloaal Research Csuncil. Sr, Jtervmld had gems mp ts Saramao em /aaaary 17th, amd was still there. Sr, Psdcard hoped ts psrruad* him ts rssama his daties there with a title sf dir seder lm charge sf ths lakerat ery. If ha dace, tme sf hit Jsb* wiil he ts tackle ths tremeadeus back!eg sf pathslaglcal mattrial amd imtsrpret it, imathar maw mam had arrlred ta vezfc im the Laboratory, at the same time that Dr, Laaxa is it ad thara, amd ha, tss, is tmgagsd am the material, ilthcmgh they hare a crew af good, expert mem la ths Lakerat ary at this time--mem whs thoroughly kmev hew ts da the job--neTsrtheleii, wham they are through, thslr part sf ths jsb it finished amd they caa gs ms further, The ce-erdinntlag head is what Is missing. If Dr, Xerwald ecaaaats ts returns his vezfc, it will ears a 1st af time amd trouble that vimld >s imrslrsd im orienting a msv mam. Primarily, ths problem mow is one sf gsttimg caught mp em the hags backlog of work, amd that Is go lag ts take oeasiderable tins, Xr, Brava inquired af Dr, Lamia whether, wham apaakiag about the dusting sf amimals, he referred to dusting with asbestos, or with dlatsmacscus snrth. fir, Lewis answered that he ueaxit diatomacsous earth. lu conuaction with the experiment! at Saranac with dimtomactorni earth, fir. Lamia said ha had found ths note a im fir. Gardner*! handwriting, apparently intended fer n report ts Johna-tlanTille. Dr. Lamia copied this material amd brought it along with him. He read ths copy, aa followst On looking through ths metes and records sf fir, Gardner, Z find that there wore 11 different series of experiment a em experimental amimals using dlatomacsous earth; theae included experiment a with crude er raw earth, ealoimed earth, amd fluxed caloins. Heating diatomaceoua earth ts 1710 degress I. forms free silica with imrsrsiom to cryotoballts. If quarts is present, there is lnrerslon ts trydimits amd erystehallte, Ttxperimento with ths calcined earth started em Tebruary 7, 1M5 with 100 guinea pigs with 50 mere projected with a view ts supplement ths informa tion on raw earth. After riiiting Lompoo, Dr, Gardner real lied that the inreetigations would need to be mere extensiTe them originally eeatsmplatsd. 00011998 Exhibit *0 One ^nlrtnrt treuhle 1a esnnec-tlc* with U testing ef *'< vlth calcined iiiiMustou sacrth vu It apparastlp p--the* an n- iiul njMpUtilitj t* fumtii oi 31 (tian pigs liii ii tta first mti, ul y) ti ia^rt, 1344, 47 pliu pig* bi lib fm tkia bom, . There nrt still surviving 11 with 14 mill exposure, 14 with T month* npmni 1bi< t b kept u ln< u }rutlaU fr itidjr *f m< 1m affects, 4ft ar 10 nsmtha njxrui tlu marlms. effesta ef til calcined earth vm a* iaflilii fibresi* la the lo^t, Ht a --i fcralgs. bedp reaction with ehrenio inflsanat Lon and unlike that obtained fro* the rear. The <ba(ii Mt*i la tk* lTiybtioi *4 that fltmli f tt oili est 14 type veuld later appear. 1 la Jennarp, 1M4, tb teat MiMttntlau wn lamoHi vithn! oqr aatibia ohange. Bill vu iu far it vu thn^kt that tha Aaa^or of p&mssoaia m otot. One hundred and fifteen mot# guinea pigs were added. Injection experis*nte late sniaals, that la, intraxenema, lnkrsme-osLljx, intratracheal, and into Via heart, were all completed tone considerable tlaa age. la general, tlqr shew that Iks raw urf natural earth has vtat fir, Gardner called a ?laa 4 Sat lac ** Sis seal* vhich (i te about I peints (trpdinite). 11*# completed were the inhalation experiments with v rav Oolite, using guinea pic* injected alee with a mild type f tubercle.' X narked shsa^u v ihm from this esperinext anil as tendency ts eaiN spread sf disease, *lv underway art experiments using ealslaed earth vlth latratraehaal inj set Ion la guinea pics as lac 3rfl** the x-rap refraction method, . this ihm 24> erysteballte, Shis vas the earth ealslaed vlth seda ash, Xahslatloa experiments were carried sm vlth calasa pics previses ts exposure ts tubercle infection, aleac vlth tubercle infection. sad . after wept sure ts tubsrole infection. Sheas expariasat rill centime far at least rat asrs pear; alts lahalatlea experiments vlth Ipfle without aap added infection* The indicationa art as far that Hjrfle stimulates tubercle infection.* It was felt that tha conclusion rsaehtd at ths tad,' te the effect that the iadieatloas are that Syflo etiaulatee tuberole lafaetioa, vaa rather disturbing sad vas ths part of the report that night girt at teat eenoem. Sr, lanea vas adeed far his opinion as to hov such tiat would he required before a defialte eeaelualem could be reached about thla, and he stated that it prebablp would taka mat 11 tha tad sf ths year; he thought ths technician who hat charge sf the teat lac ef aalaals vomld hors te carry on his experiments fsr ths rest sf ths year, sad, by the ties he evts through, the pathologist will hare baa able te cat oh up vlth his latsrprvtatleas ef the elide a. He added, that vhsa he gats bach from hia trip ts the Vest Beast, abeut the first ef June, he would like ts go back ts Saranac, as booa as possible after that, ts find out Just what progress hae been made. . r...^ V .* Te an inquiry from Kr, Zlaanbast as te whether 'the Indications are that ^fle stimulates tubarole infsotien1 vas the late Dr. Gardner's opinion, 2>r. Lansa replied that it vaa not, but that it vaa Kr. Delehan'a lmpreselom, and that "he la considered a very experienced nan. Kr, Xlaeabaet inquired further whether there vaa any tTidsnoa that Sr. Gardner had reached nap ouch eomolmaiea hima elf* and Sr. Lanta answered in ths negative, ( ' 00011990 -6- Xr. Embcit ilu referrad to a prrrioma requmat ha had made, that Sr, Lamia check, If peaalhlo, at hrwai am the darting experimamta vith a sample af Ustirana-ma aartb vklah had earna fraa the Oarhart lafraeteriea, vkieh vaa found ta eoateia edmta'tllite, ami. vhiah had pradmced the raamlta that had lnflmenoed Dr. Oardner'a thinking. Lampae ham ahipped matmrml peviern ta Oarhart, Vat ham merer shipped flmrad ealeimad mat trial to them. amd 1 waaaanh am ra had mmrar aaam thm partiomlnr sample af mat trial lm vhimh Sr, Gardner flrat dmtaotad ehrystehilite, Xr. Xlsamhast fait It vaa af lmtarart ta determine tha eeuroe amd arlglm af that sample, prompted hit Impair/' am ta vhrthar Sr, Lamia had found Bmp' reference ta it lm thm Lata Sr. Gardner's metes. Sr. Lamm aiatad that vhila ha had mat Warn ahla ta malra a check am. thia sample, ha thought it vamld mat ha difficult far amyeme ta aVtalm tha da airad imfardmtlam hy vrlting ta Saranac, am they prehahly eeuld prorldm it from tha reoerd they keep thara af nmWrt eererlng tha different lasplti mmad lm experiments* Xr. Sravm impressed iralrt that Sr. Omrdmar had carried om say dmatlng experiment vith tha snpla lm question. Tha 'Oarhart* aamplm had gIran him tha elua amd, lm fellovlmg tcp that alma, ha bad analysed seme Lcarpoo flmrad ealoimad aatarlal amd found a uhrtaatial percentage af ehrystehilite im it. 3a knev, vham ha found matarial vith thit percentage af ehryrtohilite, that ha had a 'had aetar1. Xr. lltanhamt contended, hevarsr, that tha Oarhart matarial--ta vhlch a men's daath had ha am attributed, camld hare haaa a pradmet af different prap art la a from lyfia, ar tha percentage af ehrystehilite it centaimed might hero been graatar tham im Xyfla, amd far this raaaaa ha haliarad it importamt ta try to artahliah tha seurce amd orlgim af tha Oarhart aampla. fa far aa Lempeo matarial vaa easearmed, Xr. Haaahaat thought it ahomld ha ark ahllahad vhathar ar mat tha physielegicnl affaot 1a earned by tha partiele alia af thm damt lmhalad, or hy tha ehaaleal make-up af tha matarial. Or, Lamia ehsirred that tha mahaatai product pradaoaa tha affaot mechanically. Tlth matarlala that ara chsaloally satire, havrrar, ha amid tha fimmr they ara, tha mart aotlre they ara. Hie impression vam that tha technician at ftaramme takes tha Eyfle povder juat ac ha raeairaa it fram Lompoo (vhioh ia thm regular commercial grada), amd that it ham mamy pariiele alias lm it. la promised, havrrar, ta vrita to Sarmm&o amd inquire vhathar it vam mi ad Jumt am it vaa raeairad, ar vhathar may affort had haem m&da to separate it amd mat different partiela alias im tha damtlmg experiments. 3a addad, that ha haliarad tha taohmieiam vamld routinely datazmima vhat tha BTaraga partiela alias vara. Belief vaa expressed, hovrrar, that thm datarmlmmtiom af vmeh f&ota vomld hart ma effect im changing tha imdnatrlml hygiene prahlaa mt Lompoc ar tha experiments haimg made at Saranac. Both fine amd eaaraa matarlala ara lxrolred im tha prohlam affaoting Lompoc, amd it vaa fait that ma farther time meed ha loot im eomlng to a deeielom am to vhat must ha dome to centre!'the dost aitmatlem at that plmmt. Clsein^ Before leering the meeting, Sr, Lamia offered his eerrieea 1m any capacity vhila am tha Vest Coamt daring the next four mamthm. Ha vam imfarmed af tha company1 s da a Ira to engage a comp atent Teat ilat ion Engineer at Lompao. Ha aali ha vomld heap thia lm mind and let Xr. Zlianhast Jtnev if ha aomaa acroij_sn applicant vham ha could recen- ,taA- ^^LAINTIFPS EXHIBIT 00012000 Yhea asatiaa m Bade ef the text Wok vhleh Till deed vlth lilieeeis', ul ea vhleh Xr. /bu, ef U i< )mU]r uaci ii vrittsg, Xr. kin fUik tkt W knev Dr. Jitain veil oi derahtless veald liisus vlth him. at Lot iageles. kit mnt request that ve preride ftr the heok 07 mat trial sa dlateaeseeas earth vhleh ve kmev It W Mr. >mt n^irlk to Br. Lan that, iktll ht kn eeaaslea it talk vlth Xr. Smart la Lh iageleg, ha might vaat ta disease vlth kla a reseat report be haA saAa if a eat* vhere ha Wllrred dlateaacscue earth haA haA the effect ef retardlag, er tfrl Ivg eff, the progress ef taWrealssis la a eertala iaAirlAaal vki, if he haA Wea aa erAlaax7 oase, veald her* Aled at a sack earlier Aate that, he did. Xr. Zrta tail he hrped Dr. Lease eeald rlalt Leapte Aarlac hie rlelt te the Vert Ceart. _Jbr. Laasa assured him that he expected te; end Xr. Tleher suggested that, whea he rltiti the pleat, he alt leva cxA talk rrer ladastrial hygisas matter* pereeaelly vlth Xr. Vestaoat, rather them with e greup ef five er ilx peeple. Xr. Yestaeat, he hail. haA a mere iatlmats sad thereagh kasvledge caA vadarstaadlag ef the vhele pretlaa vhieh he oealA better impart la a eearersutiea aleae vlth Dr. Lease thaa he wnli if a larger grevp vert called la. fir. Lsasa ashed Xr. Heeahaet te iafera Xr. Vestaeat that he preWkly veald rlelt Lesrpes sometime Aar leg the latter part ef Tehnarp. Xr. Yosdard assured Dr. Laasa that all these prescat fslt (ilti rsllsvsd ever the aetss he had Wea able te sVtala froa Dr. Oerdaer** fllee, as veil as the rspert he had aed# ea the experimeats la progress at Saraaae, fsr It aev teeaed eppareat that the eeapaxj voald get practically* all that it veald hare get had fir. Qardaer aet died, except, ef oourse, his eva expert laterpretatioa of the experiment*. / 1 Isailtea 0001200.1