Document q3BVjnLN6EBnZDV6MDRGboorK

Vl d? HYGIENIC GUIDE SERIES Chlorodiplicayls (Coulninmg 42% am] 54% Chlorine) '/ V-y HygUnie Gtiidt So'itt (x + y - 3 or 5) Cly Significant Physical Properties' The ohlorooiphruyU tiro light *un\vxolorcd mobile (42% chlorinated) and viscous (54% chlorinated) liquids with typical chlorinated aromatic odors. These compounds are chlorinated to specific weights of chlorine. Chlorodiphcnyl (42%) contains 42.0 * 0.5 chlorine, an amount corresponding to three chlorine atoms in tinassigned positions. Chlorodiphcnyl (54%) contains 54.3<le chlorine corresponding to five chlorinc atoms in unasslgned positions. Both compounds are insoluble in water, bus soluble in benxene, kerosene, acetone, amyl alcohol, ether and chloroform. Chlerodiphtnyl (42%) Chhrodiphtnyl (94%) Molecular weight: 247.53 326.45 Flash point (Cleveland O. C.); 176*4B0*C (349*-35$*F) None Distillation range: 325*-366*C 365*.390*C Specific gravity: U8M.392 (25715.5*0) ' 1.4954.505 (65715.5*0) Vapor pressure: 0*C 0.001 mm . 0.00006 mm ?5*C 0.006 mm (eat) 0.00054 mm (eat) 150*C- 4.3 mm 1.4 mm 200* C 29.0 inm 9.0 mm At 25*C and 760 mm Hgt Saturated air contains 0.060 mg/lher. 0.009 mg/liter 1 mg/litcr e 98.8 ppm 74.9 ppm 1 ppm * 0.010 mg/liter 0.013 mg/Utcr I. Hygienic Standards A. Recommkndiid maximal atmospheric coxctistratioN6 (0 hours): One milli gram chlorodiphcnyl (42%) pet* cubic meter of air and 0.5 milligram chlorodiphenyl (54%) per cubic meter of air.* This U based on the results of The Conunliut wlslirs to (lr>wlJ|t the pr<nrti#a at the tn<dk*l in(n>\tin stetiast at this Cvidt by the Isdusirlsl Jtjcitns and Clinical Tafcfcfttofy Ccmmiiira at j. M. A., anil la sekne*Wg atsa Hit assistsnc at Elmer f. WttseUr *i4 Jack T. Cacetlt 1a ih at this Culdt. chronic animal inhalation studies.1 B. Short exposure tolerance'. Ten mg of a diphenyl of unspecified chlorine content per cubic meter of air has been reported as unbearably irritating.4 C. Atmospheric concentration immedi ately hazardous to upr: Not known for man. Irritation of the eyes, nose and throat at levels which have not caused acute illness preclude the likeli hood of voluntary exposure to Immedi ately hazardous concentrations. HONS 035245 Janunry-/``nOrunryt !%$ . N. TokIc Properties A. !nu.\j..vtu>.v: Kxpmmoiui \viih cl i loro* ii;>iu*nyl i*t2ty fhlnrim*) wore run At , "linn in>s oi chlorncnc have not *uLrcl*?rt,,d f*'om thn iim: of thcnc two r.liWcxIiphcnyk The pottmia" v;V;:V|Ui.uu>n, ot tU\ w/Wuv And At Undoubtedly cxi.It bccnimc of ease. luor oi air. Out*, mice, rabbits Winch were reported from the ute of aiui vm wore imallVnod by die higher m'\v1 while guinea pig* showed jxx>r come?,' hW' <thlr>rinc co iteot nnd from mixture, with other . Miter seventeen 7-hourAlay ex chlorinated aromatic compound.I ,J posure* over 24 days, lvighty-fmir 7nouivoay exposures at the lower con centration had essentially no effect on c. Evit contactt The liquid product, and eye 5iZT` "r m'Klcri"cl>'irriUl,in* <> mni.ar species ot' animal*.* D. Inukhtiom: The acute oral toxicide, of In the case ol chlorodiphcnyl (54% rlnonncl eighty-throe 7-hour/day ex posures over 121 days to a conrcrttra- die undiluted compound, arc not grot ns evidenced by oral LD,,,' in rau of approximately 0.63 gm (7.61 tTM 9.76 V" ol MP/luer resulted in injury to liver cells nnd increased liver weights In rati. At a concentration of 1.5 pg/litcr gm) per kilogram (or the <2% chlori nated and 11/0 gm (10.48 to 1345 gm) per kdogram for the 54% chlorinated.' .or one hundred nnd fifty 7-hmir/dAy exposure* over 213 davs, the rats Central a rophy of the liver appear, to l>o the chief toxic effect. P snowed distinct microscopic changes in the liver.* . III. Industrial Hyqitne Practice *1 he literature contains many refer ences to the potential toxic effects of cluonnnted diphenyls in man and nnittta.*. The early work included invest!- pAitons of chlorinated naphthalenes, chlorinated diphenyls, chlorinated diphenyl oxide and various mixtures of tnese. An early rejsort indicated serious toxic clTccu from chlorodiphcnyl chlorl- nated to the extent of 6$%.* A later report by the principal author properly % sc-omificd me earlier sample at a mix ture of chlorinated diphenvl and chlori nated aiphcnyl benzene.* however, only a tew authors of subsequent papers, bul letins or textbooks have noted this cor rection and the original data are cited repeatedly as relating to chlorinated dspncnyl alone. B. Skin contact! Both compounds are readily absorbed through the clipped, mtact skin of rabbits. The minimum lethal dose when the undiluted mate rials were applied to the covered c.ippcd, intact skin of rabbits for 24 hours was approximately 1.0 gm/kg for the 42% chlorinated and 1.5 gm/kg for the 54% chlorinated.' ujed a. dielectric, for c3cnri! capacitor, and transformer., pia.tici.cr. in synthetic rc.ini, in emul.ion adhes Ives, a. nonflammable hydraulic fluid, ana as trAnsfer media. B. Evaluation or exposure. : 1- Air sampling and analysiss a. Direct field method.: None . b, laboratory method.: (1) Collect in secondary butyl alcohol in fritted bubbler or two large .hnpingors in icrici; concentrate sample and complete analysis by ono of various method, for chlo- 'noted hydrocarbon.,' (2) Sample air through com bustion furnace, collect chloride ion from dccom- posed chlorodiphcnyl in suitable alkaline solution and determine chloride ion con centration.* O. Hazards and their aboommbndzd OONTrol: Local action on the skin is similar to that of common organic solvents where contact leads to removal of natural fats and oils with subsequent drying and cracking of the skin. Inhalation. Concentrations In the workroom Atmosphere should be maintained below the recommended levels. Where the chlorinated diphenyls are used at room tempera* MONS 035246 J<usmin'mt'\'in uai)\ IfHiJ uiivs. ihu lu.-.ml of inhalation Ik oomuiorod slight or absent. Wlun ihoKt* materials niv subjected to cU'V.Hod h'IU]KTAUm't;, lltC pi'OCOM cither should bo completely enclosed or othor adequate mechanical exhuust ventilation must bo provided 10 reduce concentrations to *afc levels. In boat transfer media nppllC.*vi ions, the system imiti be designed and constructed so that it is leak* proof. Special gasket materials and pump seals arc available in prevent leakage. The ivscivoir tank should bo airtight except for a Vent to the outdoor*. In the event of spills or leaks of hot fluids, mo chemical cartridge respirators or gas masks . approved by the U. S. Bureau of Mines for protection against organic vapors. 'I hose will provide good protection up to the concentrations shown on the approval labels and the odor trill give ample warning if it comes through the device. 2. Shin contact's Operation*and hand!* ittg procedures should be such at to avoid the possibility of prolonged or repeated skin contact. Contaminated clothing must be laundered before reuse. 3. )V contact: Eye protection should be used where there is a possibility of liquid splashes. 4. ingestion: Ingestion of these mate rials U not a problem in industry. 5. Fire and explosion: Tito chlorodiphenyls arc fire-resistant or essenti ally nonflammable liquids. When exposed to flame or hot surfaces they may decompose to form CO, CO;, HCI, phenolies and aldehydes depending on the temperature, avail . ability of oxygen, area of the heated surface, rate of application of the liquid to the surface and other variables. IV. Medical Information A. Embrovkcv treatment: Skin surfaces exposed to chlorodiphcnyls should be thoroughly washed with soap and water at. once, if clothing has been contami nated it should be removed promptly. If* exposure to a high vapor concen tration occurs, as in the case of spills at elevated temperatures, the patient should l>c moved from exposure and kepi at rest until seen by a physician. Oxygen should be administered if breathing k difficult. Eye* contaminated with chlorodiphenyl should be irrigated with water for at least 15 minutes and the patient should be seen by a physician. Depend . ing on the amount of inflammation and pain present, drugs like Cortisporin* ointment and topical Pontoc.alnc* may bo indicated. B. Sei'.oiAL i'rockduri'.s : Persons who are regularly or repeatedly exposed to chlo* rodiptwnyls should be examined periodi cally to detect early evidence of skin irritation and/or liver damage. Persons with known liver disease should not bo exposed to repeated contact with the chlorodiphcnyls. V. References 1. Monsanto Conmany, Organic Chemi cals Division: Tech, Bulletin # PL-306, Aroclor Plasticisers (Dec. 1960), 2. American Conference of Governmental Industrial Hygienists: Threshold Limit Values for J964. AMA Arch. Environ. Health 9; 545 (1964). 3. Treon, J. F., F. P. Cleveland, J. Cappel, and R. W. Atchley: The Toxicity of the Vapors of Aroclor 1242 and Aroclor 1254. Amcr. Ind, Hyg. Attoc. Direr/. 17:204 (1956). 4. Elkins, H. B.: The Chemistry of /nrfui- trial Toxicology. John Wiley and Sons, Inc., New York 0959). 5. Drinker, C. K., M. F. Warren, and G. A. Benner. The Problem of Possible Systemic Effects from Certain Chlori nated Hydrocarbons. /. Ind. Hyg. Toxicol. IP: 203 (1937). 6. Drinker, C. K.: Further Observations on the Possible Systemic Toxicity of Certain of the Chlorinated Hydrocar bons. /. Ind, Hyg. Toxicol. 21: 155 (1939). 7. Wheeler, E. P.: Personal Communica tion, Monsanto Company, St. Louis, Missouri 63166. * 6. Creenburg, L., M. R. Mayen, and A. R. Smith: The Systemic Effects Result ing from Exposure to Certain Chlori nated Hydrocarbons. /. Ind. Hyg* Toxicol. 21:29 (1939). * MONS 0352*7 HYGIENIC GUIDES COMMITTEE C. \\ CAKri.Nn'.K, Chairman N. M. itoi.vox E. E. C.o>imn.v J. H\ Cl.AVTON It. It. Ei.kisk ?. D. Malu:v Mark Urn: J. A. JIOUOIITON D, R. McFi'.k J. M. MoNkrnkv, Jr. J. E. Pcthron J. D. OumiNir*Ki E. A. Phtzkr U. C. Por.zANi K. L. Rai.i.idii W. L. Sutton R. C. Wand* C. L. W.L.ON hypirme Guido ihcct* my be obtained from the amkrioan industrial hvoicm ARROCtA* non. 1-iU.S Prevmt, Di-iiitU Michlwan, At 25 cent* cneh lor iwO'iMwe rcprinti; $0 cent* each tor jour^-Tpe reprint*. Ail order* lor Ini thou $2.00 must bo prepaid. Discount olf.20% on wter* oi' mv or more Guide*; 40% diicount on order* ol 100 or more Guide* Spe<cifcl loo** kvo binder* (or the Guide* may ai*o bo ordered Irom the Awociation office lor $1.25 each, MONS 035248