Document q332gDDkpBExqOp2NdQJvXGeE

Rationale and assumptions Applied Health Sciences, Inc. Case-control Study of AML and NHL Additional Budget Estimate for 2007 and 2008 2006/11/18 Assuming that the end of case accrual will be extended to December 2007, we will need to extend the timeline of the case-control study to December 2008. We further assume that final diagnoses of all patients and patient interviews will be completed by March 2008 and exposure assessment completed by June 2008. We will then perform the following tasks in JulyDecember 2008: final QA/QC, data editing, statistical analysis, presentations, discussion with SRP and report writing. In addition, based on our recent experience, we need to increase our efforts of QA/QC, database testing and auditing, and monitoring of patient interviews in 2007. For 2007, we have also added two additional trips to Shanghai (to the three already approved, with a new total of five trips). Labor Hourly rate Year 2007 Year 2008 Total Category in 2006 Hours Amount Hours Amount Hours Amount Chief Epidemiologist (PI) $355 120 $42,600 540 $191,700 660 $234,300 (J) Biostatistician $175 80 $14,000 400 $70,000 480 $84,000 I Statistical programmer m r Research/Adm inistration assistant r Consulting industrial hygienist s:I Total labor in 2006 dollars $150 $115 $250 80 $12,000 400 $60,000 480 $72,000 20 $2,300 160 $18,400 180 $20,700 0 $0 80 $20,000 80 $20,000 $70,900 $360,100 $431,000 () () r Meetings/working trips (time & expenses) C Unit cost Year 2007 Year 2008 Total ;a in 2006 No. Amount No. Amount No. Amount G) I Trips to Shanghai (10 days each) $37,500 2 $75,000 5 $187,500 7 $262,500 0c..n Trips in USA (3 days each) $11,600 0 $0 2 $23,200 2 $23,200 ex> ..j:::o. Total for meetings/working trips in 2006 dollars $75,000 $210,700 $285,700 c..n I'V Applied Health Sciences, Inc. Case-control Study of AML and NHL Additional Budget Estimate for 2007 and 2008 2006/11/18 Miscellaneous expenses (copying, domestic & international calls, mail) in 2006 dollars Total additional budget in 2006 dollars (labor, trips & miscellaneous expenses) $1,000 $146,900 $3,000 $573,800 $4,000 $720,700 Yearly budget estimates with a 5% annual adjustment Year 2007 Year 2008 Total Total additional budget by year (with 5% annual adjustment) $154,245 $632,615 $786,860 Budget already approved (Contract No. 2004101153, Amendment No.1) $456,475 $0 $456,475 (J) TOTAL REVISED BUDGET I m r r sI : () () r C ;a G) oI c..n ex> ..j:::o. c..n c..> $610,720 $632,615 $1,243,335