Document pr6pJ74MMQmkyaD5mvw5BYdd

TRADE SECRET AR226-3208 DuPont-8864 Study Title H-25124: Corrositex In Vitro Test Laboratory Project ID: DuPont-8864 Author: Carol Finlay, B.A. Study Completed on: December 12,2001 Performing L aboratory: HE.aI.skdeullPLoanbtodreatNoerymfoourrHs eaanldthCaonmdpEannvyironmental Sciences NElekwtoanrkR, oDaedl,aPw.aOr.eB1o9x71540-0050 Work Request Number: Service Code Number jp7 Page 1of9 Comoany ganlffeeS. Does noi conialo TSCA CB H-25124: Corrositex In Vitro Test DuPont-8864 CERTIFICATION We, the undersigned, declare that this report provides an accurate evaluation of data obtained from this study. Reviewed jj O' JamdsC. VMackay II Associate Scientist 6iT'c. - p-eo/ Date Issued by Study Director: Staff Sdentisi n - 'VDaute . - t o *) 2- - CsMpgfffSslffesd Sosa f,o! contain mcik Ci H-25124: Corrositex In Vitro Test STUDY INFORMATION Substance Tested: Svnonvms/Codes: Haskell Number: 25124 DuPont-8864 Physical Characteristics Sponsor: WE.Ii.lmduinPgotonnt,dDeeNlaewmaoruers19a8n9d8Company U.S.A. Study Initiated/Completed: November 19, 2001 / (see report cover page) In-Life Initiated/Completed: November 20, 2001 / November 20, 2001 -3 - Sanitized. Does not contain TSCA CB1 H-25124: Corrositex In Vitro Test STUDY PERSONNEL PrimaSrtMyudTayneacDghienrmeicceitaonnrt::: CJJauamdrioetlhsFCCin.. lMSatyaa,dcBlke.aAry,.PIIh.D., D.A.B.T. Toxicology Report Preparation: Lisa G. Burchfield, A.A. DuPont-8864 H-25124: Corrositex In Vitro Test DuPont-8864 I SUMMARY Hbapsar-sos2aed5ydu1.co2eC4naotwrhcraehosastiinetmegvxeaeliruneaiqstaeuacdirhsefteodamrnfdsiockarairltndhdicezeoettreedrscoattsinsoiduonbnqssupytaaosnntteectminetta.titoailvpeuasisinsngvthittrhrooeucIgnohraVroibtsriioovbiItanyrtreteiresnrta.mtiToehnmeablmrCaonodrereoalsniisdtex dAind anloiqt upoastsotfh5r0o0ugfihLaonfyHo-f2t5h1e2m4ewmabsraanpepsl.ied to each of 4 membrane discs. The test substance Under the conditions of this test, H-25124 was not a corrosive. . CB!-5 - Company Sanitized. Does not contain TSCA H-25124: Corrositex In Vitro Test DuPont-8864 INTRODUCTION ITnheVipturorpIonsteeronafttihoinsasltuCdoyrrwosaistetxodaestesramyikniet.skin corrosion potential ofH-25124 using the MATERIALS AND METHODS Test Substance Tssuuhbcehsttaeansstcaesucahbpasptnaegnaecreeind, Hctoo-2lbo5er1so2tr4apb, hlweyaussincsdauelprspttahliteeed,cwobnyadstihtoiebossnepsrovonefsdtoh.reassturdfyl.HNBo VeviHdeHnceiWof irnhsteabtielistty, B. Principles of the Method mpTcCorhoeomermprporabiosserissattaeeanydxreyiosabfnibiswdoaabsatnoeatedricrrniaoeauvnrnsidmtterhopeeamHacasobbisnlriaoladiyrntiyceucahoscteafoodnanrgtsdcoeiyosidetrnsrseo.otteshfCirevmaoelrriiqenrteocuessoiittdnthesseCuxtibhstksuetiimtasnenidccccoocaenolrtrdlDooluasepcgitatoeeesncndstpimitoohnnitrxteohStnuurytgeriseaeht.lesaomtTebfphi(aoseC:btDeCasDrStr)iSs.euribTsshtaence. 1. Qualification Step pTlhaecetedsdt isruebcstltyanincetoisapvriea-lqcuoanlitfaiiendintgotehsetaCbDlisSh. cIofmapcahtaibnigleityinwciothlotrhoeracsosanys.istTehnecyteosctcsuurbss,ttahneceteisst substance can be tested by using this assay. 2. Categorization Step tcTsaouonhbldaiosstcrthsaoctenlehocpvaerineacigslshsetaapairblntral.eiceseToahdbchehsseientvtrthevoiaeseltVd.csaiufaCtobelargsAttaoeagr(ncycoocoroelyonfitrst1ahciaanhesnaistndneigggsCnteaaes.ntudeAabgtcsooictdareoynilbtco2huerefafcfrreoheCrra)ianunatgsedneegidcoioanVrbtyitsivhae1elervoBocerlfda(Ctcshiaosnetinefettigiacimotiahnrteeyiionrs2ngcvabisaalatelebsspiaes.usdemsToebhanduetcfitthnhfeeeestrdht),e classification step. 3. Classification Step rmtThehgeaimtusltbahstrteeiaopntenedss.teatsAenurdbmcscotillanaonesrcsscieifhfihcataanhstgeipoetaneosssrst.ecsdTounbhthsseirtsatoetnuescgntehcsyiutshbcaeshtasamknneigcnmeecbiinosrraatrnhpoeeps.ilCviTeeDdhaSeoccnbdoeetrnotdeeprianmotghfintttohahteeUiopmNnroeoampnfrbidceroatDranrrOoeysTibinvidoei/bcnaaortnrei-ser 6- a iiB iii? Wen! :no! ccnS! rsca C H-25124: CorrositexIn Vitro Test DuPont-8864 csuobrrsotasnivceeatondptahses tPharcokuignhgtGheromupemasbsriagnnee.dTahree tbiamseedscoanletshediafmfeor ufonrt Cofattiemgoeriyt t1aakneds t2h.e test TvGihraoelsucpdaetbetyegrocmraytienagesostrhiygenapenaddcakbnirndegatkhgterhomruopeua.gnhTvthaiemlufeeo.lolofwthiengbrteaabklethirsouusgehdttiomaesfsoigrnaltlh4e saapmprpolperrieapteliPcaatceking PACKING GROUP DESIGNATION Corrositex Times CCaatteeggoorryy 21 0 to 3 minutes P0atcoki3ngmGinrouutepsI >>P33acttkooin36g00GmmroiinnuuupttEeetss > 60 to 240 minutes >P3a0cktiong60GrmouinpuHteIs >N>o26n40-0Cmmoirinrnouustiteveses > = greater than C. Protocol Tt(tmacmm25hh2op0hmeeaae-npe8mtdtmddrriiwbonieabuiCxixnunyarmo)iutaspsbmpeanutopassertenawpiirsltoottar)eodedii.ncrleeileea.stydtrrTochdl.mlTus1heoconTehwweiobnntemhnsiiecolaatederbhibnternuhhvrayoatckorieiranetfnrtariblemeiwnioperiwgblcodoraabobaivttmtausehnesaencbr/teerdtsdmebrmhaaniplfneheaestbrrndrsgesosoraanmmaophvtytoenleifa.watdetaittrhcscehrtAieeeeisderwxsedderttbbeheipttitriyorfoneuoorerresrwtibt6mhignrhpda.8deeeerore-eerdrTm7msapritue0tohhawaoerrfeerntfrfCeadea..uwwdsric.fl.TTeaawacuW.ttochheTeeatmneerrsuhhtbbtrespiirwlenoaaleabresltteyhiuhtetworeh.trleicbleiteoydeoTaranwdenrddhwrtdriasieiasaenetetisosemmtrdnoorrrmeeailtebxvraoidmeantewwumttiedohhnradabvee(stwaraeievwanfpdrraiinepalsabttlefhsrloeawrsoediotspgxhwatfwwreiirrmcbeemrarioraviettaeoithneednotbntrpegraaatlbr,iyrtenartphiteehaerrrfeodr wTwwarasopcphoeuvdnedwrereidtdhamnpdliacnsrtooiclaitwierrrbsaupwbaabnsledpsiipmheamtdteefddoiriamntteeoldye. astTcohhreemdfeiimlnlebadrraternfaeryidgcieosrcna,ttaoeinrns(iu2nr-gi8nthgCet)h.beioebnatmireermsewmabsrane 1. Qualification TsqChuhoaarekrliotefesnysi,ittneasxgnudtbhsasetylaltsnoetcwseetmeswd.uabtAosstfsa1itnr5asc0ntedftieffLosotrraeudl1isqtemouioindnteutothteefer.tmhCAeiontrecerohsistafinsttehugxebessitanasmnyccsoptelleoewmrwa.osarsacdcodonemsdipsttaoetnitbchlyeewQwauistahloitbfhyseetrevset dtube, - 7 - Cam pany Sanitized. Does not contain TSCA CB1 H-25124: Corrositex In Vitro Test DuPont-8864 2. Categorization mTA(cwiox1noe5td0ad.irnoiTiLpnhsgaeolaicfqboCualooosternofwbifruaHmfsf-emR2r5)ae.at1cg2Th4ehenwdet awvtosieatarlhedsedwaecdedodrleetoodrcsVatoopianpVletidAhaela(Bnccdo.olnsoTthrahaiceknheivannirga.tsla.NwnoTaashcceiocdalcopborpulcoefhfrdeacarnh)ngaadennsgwdheaaVpskileoaanlcbeBsuednrttviheled. sample in Category 2. ' 3. Classification Twteow"lCha+vfheDebee"terreh)nSbeelfeliceiaytowodlh4tlbnaaeer"atptsdnoe-arp"orsaito)linrtmiebnacievrnsyaoditemrgaencrrolmtoovassnauwetnpi(rdtnltvieofaxsiiurfpintaanorrwgltieoirsucnaacfarg1smaiett-cchprt4(hihieol1d)caae.f]7dncacb-ieaOgc2soidneico5nlddobiie]annrC.aanvtrcno)dtAirhh.oaiaaeealtWvhrnwtcCsieighamiarDwetleshwemSlabiasrsan.eibiwsncmpe2TaeuaslilhaemisltmadtdeohsireniftClnlttayiuaethrrostrsctteelretetycesibdrior,avn.ituntroaedeseTndbishdacayhetaaawemsidsltsdtiiieqoeaitpmcwhurnrCeoodia.oD(ttcihCfpseoAScotDdafh.sucm5SeniorTt0e)eeipl0ghvmovowaeerijsbatuaicctilrLtivso.oiamvennonfTeoettecfrrlhocoHioldteoonlli-.twntsC2o[rct(To5eorDvcold1khiSola2[eff(nli4ovovvntlriraiwaiaataiebthllnahlaseseiseclnehgd positive control to break through the membrane was documented. -8 - Sot contain i CB1 H-25124: Corrositex In Vitro Test DuPont-8864 RESULTS Breakthrough ofthe biobarrier occurred as follows (hour:minute:second): VVVViiiiaaaallll 2431 ((((TTTTeeeesssstttt SSSSuuuubbbbssssttttaaaannnncccceeee)))) ---- NNNNoooo bbbbrrrreeeeaaaakkkktttthhhhrrrroooouuuugggghhhh VViaiall65(N(Peogsaittiivvee CCoonnttrrooll)) -- N00o:0b1r:e2a1kthrough CONCLUSIONS Under the conditions of this test, H-25124 was not a corrosive substance. RECORDS AND SAMPLE STORAGE NSpeewcaimrke,nDse(liafwaaprpel,icoarbalet)I,roranwMdoautan,taainndRtheecofrindaslMreapnoargtewmilelnbt,eWreitlaminiendgtaotnH, aDseklealwl aLraeb.oratory, - 9 - Sompany Sanitized. Does not contain TSG CBI