Document ppzLEZayXzp9bRG1a0e8Xk5zD

TOXICOLOGY INFORMATION PROGRAM SMITHSOKlAri SCIENCE INFORMATION EXCHANGE' Room ^6 j 1 /Zj M Street, N,W Washington, D C. '.T055 NUbttfi K i 11 > Telephone (7J5i 55'.- < " Tele* SOACo 1, -.:.J /</ 7 ----- -4--------- Supporting organization National Institute of Environmental Health Sciences Research Triangle Park, NC 27709 SUPPORTING ORGANIZATION NUMfiCR<5) Conir-jct No and/or Control No 72-2084 PROJtCT TTTLE Toxicity of Vinyl Chloride Monomer (VCM) and Vinylidene Chloride Monomer (VDM) INVESTIGATOR! 5), Dr. C.c. Lee Dr. J.J. Woods DEPARTMENT/SPECIALTY. SCHOOL OR DIVISION Midwest Research Institute Biochemical Toxicology Group, HIEHS PERFORMING ORGANIZATION Nsme and Address. including Zid Code. Midwest Research Institute 425 Volker Boulevard Kansas City, MO 64141 PEROO FOR THIS NRP Sian Date: December 1974 End Date December 1977 Annual Funding $70,000 PROJECT Summary: Be brief--200 word minimum (Include Objective, Approach. Current Plain and/or Progress) Rats and mice of both sexes were exposed to 50, 250, or 1000 ppm VCM or to 55 ppm VDM 6 hrs/day, 5 days/week for their lifetimes in closed inhalation chambers. Methods employed to determine toxicity of the compounds included chromatographic procedures, spectroscopy, histology, pathology, hematology, immunological techniques and cytogenic analyses. The project is continuing to establish VCM and VDM response profiles for use in high to low dose, animal to human extrapolation studies. CAS Registry No. Vinyl Chloride Monomer 75-01-4 Vinylidene Chloride Monomer 75-35- TOX-TIPS SEPTEMBER 1977 16-45 Tfie bibliogiaphic iclerenccs (author, title, source) on this page have been obtained Irom searches ol the lollowmg National Library ot Medicine's on line retrieval files' TOXLINE. CHEMLINE. MEDLINE. SDILINE. and CANCEHLtNE The searches, made on the substances that are the sublet ol the test described m the Notice o' Research Project. usually have retrieved the most recent citations Irom these tiles Because these searches have not been exhaustive the investigator may wish to obtain more complete searches on the test substances by searching the NLM on line hies or by contacting the Toxicology Inlormation Response Center (TIRC) at the Oak Ridge National Laboratory. P 0 Box X, Building 7509. Oak Ridge, TN 37830 -- Phone 615-483-8611 extension 31433 BARTSCH H ; MONTESANO R Mutagenic and carcinogenic effects of vinyl MUTAT RES; 32 (2). 1975 CRECD 1976) 93-119 chloride. FEROK VJ ; SPEEK AJ ; Ml'LLEMS MI ; VAK BATTUM D ; DE GROOT AP Observations on the oral administration and toxicity of vinyl chloride in rats. FOOD COSMET TOXICOL; 13 C6). 1975 CRECD 1976) 633-638 Hefner RE Jr ; Watanabe PG ; Gohnny PJ Preliminary studies on the fate of inhaled vinyl CVCM) in rats. Environ Health Perspect; VOL 11, 1975, P85-95 chloride monomer Jaeger RJ ; Mullen FE ; Coffman I,J ; Murphy CD Vinyl chloride hepatotoxicity and its alteration by modifiers khepatic biotransformation m the rat 'proc, Eur. Soc. Toxicol.; VOL 17, IS5 Predict. Chronic Toxic. Short Term Stud., Proc. Meet., 1975, 1976,301-8 of JAEGER RJ ; COHOLLY RB ; MURPHY SD Short-term inhalation toxicity of halogenated Effects on fasting rats. ARCH EHVIROH HEALTH; 30 (1). 1975 26-31 hydrocarbons' LOPRXEHO N ; BARALE R ; BARONCELLI S ; BAUER C ; BRONZETTI G CAMMELLIKI A ; CERCIGHAHI G ; CORSI C ; GERVASI G ; LEPOP.IHI C HIERI R ; ROSSI AM ; STRETTI G ; TURCHI C EVALUATION OF THE GENETIC EFFECTS INDUCED BY VINYL CHLORIDE MONOMF.RC VCM) UNDER MAMMALIAN METABOLIC ACTIV ATION = STUDIES IN VITRO AND IN VIVO MUTAT RES; 90=85-96,1976; CA 89-160906 GCHUETZ RESULTS R A B BIT S TOXICOL BA ; OF A APPL LEONG BKJ ; SMITH FA ; BALMEP. M ; G EH RING PJ VINYL CHLORIDE-TERATOLOGY STUDY IN MICE,RATS PHARMACOL; 33=139,1975; BI 76-6808 AND WITHEY JR ; COLLINS BT A statistical assessment of the quantitative uptake of vinyl chloride monomer from aqueous solution. J TOXICOL ENVIRON HEALTH; 2 (2). 1976 (RECD 1977) 311-321 TOX-TIPS SEPTEMBER 1977 16-46 I