Document ppqv4jgnpvJR4vvEd04OEEBRa

A July 15, 1959 Mr. John Tons ley national l.'ater Quality Laboratory United States Department of Interior 6201 Conydon Blvd. Duluth, i'Jimieoctn 55304 Dear Hr. Teaaleyi Conti, rcilns; our Mr. Garrett's conversation with Don Mount, I have cnclosed covorai items uiuch 1 hone will Main amply the.* ini'or.oation .ecrue-rca-u in your telephone call, i'-neionui-o one in a c-,.>y cl a table ah-i.'ihf', the a,or; ami physical properties or our j > .< 1 /obi orinn t 0 e i.J. ;.a eir.-la .an nroolcrs. a.:e hu -cri (..* 1 tSon-t;ion el the co: r: maids indieatea v.i.e ('oa 1 o>. / .0mw, . ius itvv ciu.a 2vr. phenylc chio-'inatoe to oho extent laulcreed ly the kart tv.o nu-r. reals. I nr Ic, A.-pclcr 12in biphenyl rikor.inov.ed to the extent cl '.'2; >; Arocior 12b-! is biphenyl chlorinated to 5;'>-. The 5^00 nerioo ere torpheny3a chlcr.1 anted to the extent oi` the lcu> two nuvoru la. 7`huc /-.roc-lor 5*ieO S.c terphony1 chlorinated to 60k. .t.-.o to and 4d;)0 material:* arc mixtures of biphenyls and tc-rphenylis chlorinated to o5!->* V.'e have typed on the bottom of the table the re- nulto or acute toxicity studies. i'hoac .indicate the ftpiiroxiiwito lethal oor.e in rata when ud;.rinisbereu orally arid the minimum lethal dose when the ?3i!i.:ole-s were nonlied to the enbivAm t,hio oi* rabbits. You will note that the oar-ples ware a cl.o.ui ace rod undiluted or an varioua concentration?; in coin oil depenuin^ on the physical lorm ol tire cample. OSM 018425 STLCOPCB4004969 s Mr. John Teap.ley July 15, 1959 Page Two '. ' The second cneloau.ro describes the results of chronic inhalation studies to fwoolora 1242 and 1254. The results of theca studies led to the preparation of the third ena 1 osure --Mygione Guide prepared by a committee of the American Industrial Hygiene Associa tion. The acute and chrouic inhalation data have led us to the conclusion fcha t the Ar odors are not seriously tonic materials, The industrial use and manuiactur- ing, experience for over SO years couiirms the low degree of hazard, He have never indicated that the poiyclilorina ted bl phenyls are "non toxic". We do recognise that the can be systemic effects if there is pi'ol on,pod and r cpented inhalation of vapors when the materials are used at elevated temperaturns. We have also warned a bout prevention of repeated and or ./longed' ` con act, also because of the poeui- bility of ay; injury. Vo currently in both rr; fcs id dors. We also ore investigating, th 0 noseidif lee effect:;, on rooroduotien in rate. An other nd' will det'-r-rnin'; the effect on chichemj > Of2 proibv. Gi , h.- ;:ch ab.il ivy, or a, oP.dl C-h : <. . i .! U* ;i I1 fc' -- t:juj./.'.i. bo plan to cu/itti; ce Lmo study in r U1 Us ing the ro we have do to 43 and 54;fj chlorinated biphenyla. At ambient temperature /.roclor 1242 is soiude to the extent of 203 (plus or minus 10) pgr.;; Arocxor l;l'4o--106 (plus or minus 14) ppb; Arcelor 12p4--50 (plus or minus 2) ppb. ' In preliminary fish toxicity studies, the results from our consultin': laboratory indicate that rainbow; trout survived ljC' hours in '..a tor con cr laing give ter than 10:) lor 1242, 125-4 uud liba. Tr.o c;6 hour 'in/; for bluegill van O.i'6 wp;.i for Arcelor 1242 and 12p4 and greater than 100 ppm for /woelor 1250. Those fish toxicity data ore confusing to us if one considers the ppb iv.nyc of solubility. Vo are cur rently trying to confirm the results for additional analysis. 05w 018426 STLCOPCB4004970 Mr. John Tennicy July 15, 1969 Page Throe The only published dots on fish toxicity of which we are aware ia a March, 1957 report from the 11 eh end Ulldllfc Service. Thin report resulted from a study of the toxicity of more than 4,000 chemical0 to larval lampreys, and fishes. The enclosed for-ox copy of the title pane of the report, the explanation of the table and the tabulated results indicate that the four Arcelor compound investigated snowed no effect at 5 ppn ih this abbreviated experiment of 24 hours. I have also enclosed a copy of the method of analysis developed in Sweden. This io currently being used, I believe, by tho notions involved in OECD committee work on pesticide residues. Professor Uidmark at the Institute* of Analytical Chemistry, University of .Stockholm, provided us with this copy. In May ho told us that os with many gas chromatographic methods, it has been difficult to reproduce results In various laboratories using this technique. There is underway at the proa-ant time, I believe, a very extensive program of exchanging samples among a number of lab oratories In luro-io to determine if the proccunre will produce the t.r-.uo results (within rc* tonal 1 e limits of experimental error) from the several lab oratories. bo have not u yet iUlcd r v. q -- * of crop; iq in conoidcrabio quantities tho auiviUua 1 ir, er.o:, be will la happy to provide, of c01*roe, DaK.pj.es 01 tho materials as we manufacture anu sell then. These are actually in t v;e are ur. in our analytical laboratory for reference materials. If you would like such eomslos, please let me know. Jly associate. Jack Garrett, will be at Duluth the woak of July 2U and I am cr.ro he will try to res you also at that time. Also, be. Scott Tucker, who has icon responsible for sotting up our analytical facilities, will bo very htpoy to discuss any details concerning the analytical technique. If we can help you in tins respect, please let me know. Very truly yours. rPW:Ju Elmer P. Unoelor Manager, Environmental health DSW 018427 STLCOPCB4004971