Document ppmoGm83LrJ4pG4w4Y049KDVa

oo Ur. T.S. Foloy - New York itr. Paul 7/)fua - St. Louie Dr. R.L, Jen kina - Anniston lleosrs. FJpar I. Hardy J.F. Reevoa (2) A.N. Fllenburg. R.P. Locwen December 50, 194? Celanesa Corporation of America Central Research Laboratory Dunmlt, Now Jersey Ocntlenem Dr. L, s. Blmbaua As succ.csted by Or, R. L. Jan\lna In hln letter to you on December 23, wo ore ploaoed to tnrlto ebout Aroelor toxicity considerations. The boat publlabod Information about the toxicity of Aroelor vapor* with roferenea to possible dojner.e to the liver la in a aeries of three articles written for tho Journal of Induatrloj Hyrlene and Toxicology. . The first article appeuring in the September-1937 issue,--* Vol. 19, No. ? and the second article published la the February 1938 Issue, ToL 20, No* 2 were written by CyK. Drinker, N. P. larrcn, and 0. A. Bonnet and cover only ArocJor 4483. The third arfelole written by Dr. Drinker alone la sore complete ea It gives Information about Aroclors 4465, 1254, 1268 end 34C0. '-'c particularly wish to refer you to this article entitled, "Further Obaerratlons on the Possible Oyatonic Toxicity of Certain of tt Chlorinated hydrocarbons with sugrestions for Permissible Concentrations in the Air of workrooms", s.by Cecil X. Drinker. The Journal of Industrial hygiene sod Toxicology, Vol. 21, Bo. 5, May, T5551 In this article Dr. Drinker tabulates the permissible limits of the oonpounde la mg. per cubic meter of air In workrooms. The .following data la an. excerpt pertslnlnr to peralnelble limits of various Aroolora: . - Permissible Limit Material lie, per Cu. M. 1 Mo. S Aroelor 4465 le. 9 , Aroelor 1254 ' .: 1 10. 13 Aroelor 1268 ' . MO. 14 Aroelor 5460 0.5 0.5 10.0 0.5 * Proa this. It Is noted that there Is a nurkod variation la the toxlelty of the vapors of different Aroclors. To quote Sr. Drinker, "Aroclors 1268 Is almost non-toxic*. Tit' vcporc of tho other Aroclors studied are toxlo and should be avoidod. In -cneml, tho more highly chlorine ted biphenyls are laaa toxlo than tho lower ohlorinated derivatives, probe- STLCOPCB4025077 oo bly due to decreased solubimy. Tho chlorinated torpbenyle appear to be acre toxie then oorreujnmUr.r. chlorinated biphenyle. iThero the oold or solvent nothod la used for the inpregnetion of Aroelore oeually only nomol preetutlona or ordinary eleonllnea* of commercial pleat practioo are followed. When the Aroelora ere applied by hot netbods, 300* T. or hlr,hcr, tho workrooms should be vontiloted by Intake end exhaust fens of sufficient volume end voloeity to reaove $h* majority of tho fumes. t/hore ever drying ovens are used, the vupore rust bo renoved. 9ugreatlone obiut this are given 1b the ertlele entitled, *Obaerntlons on the Toxie Effects Resulting from Exposure to CMnrinnted naphthalene end Chlorinated Phenyle with Succ*otlons for rrovetLlor.", by Dr. H. Von tedel, Dr. to. A. Holla end Dr. Janet Denton, published la The Ruhbor Are. Vol. 33, Mo. 5, August 1943. '" " " Zn general, it is believod thot tie auxlrain peralstibl* amount of Aroelor vapor in the woricrooa le evident to the worknen beeeuso of an irritating Influence on the eye nesbronea. Zt therefore beeenes e self-revealing ai?>nl wbe>; dsnrcroue levels are reaehed. If you desire, we will be clod to Irnd you an instrument i*lcb ve have with full instructions for Its operation to nosaure Aroelor vapors in your workroom atmospheres. Tbio would be the moot oerteln method to determine that your working conditions are safe. ' Zn your letter of Docsnbor 19 to Dr. Jenkins, you asked whether studies Lavs boon nods of tho ponr.Jblo toxicity or demetltle due to finished manufactured lion* eontoInins Aroelora as an ingredient. Zt was determined by the skin patch text procedure given by Dr. Louis Sohvmrtx and Ir. Sanuel W. Tbck lr. reprint Ho. 3533 from the Puhllo Health Reports, Vol. 39, Ho. 17 (April SO, 1944) that canvas painted with Aroelr 3460 and an oil modified olkyd resin in such a manner that eseh square inch of f<*brle eontolned 10.3 mg. of Aroelor 3460, was neither a akin irritant. >r Tltlrer. Tin following oomwrolal tp.ill cations oro some typlenl lnrige eurrent outlets for Aroolors and to our to\*lcd*#, there is so inetonoe of . difficulty about toxicity cvr;* in a number of these aoplleetlohs elevated temperatures are wood and eonsumers eons in rather aloes eon toot with the finished eamodlty containing Aroelor, ^ 016790 1, Actuating fluid for tVrso.nfcets. / ' `- t, Heat transfer nodiun. - 3. Non-fletaabl hy.'.Tt. .lie fluid, eepaeially . for die eoatinr. n chines. 4. Adhesive* far -.iy -or-r.-os; 5. Vood preservative and sealer trostnsnts. 6. Air eoapreaeor lubrleent. . - T. Plasticiser for nitrocellulose, ethyl cellulose , and polyvinylchloride coatings. (Zn s number of application* of iMo typo tbc eontsuner eones in STLCOPCB4025078 oo s intimate oontect with tl t coat In? eonpoaltiona. A good example la coo tod bools of lodiae' shoes). 8. riaatloizer for iHirlon and Pllollto point a and coatings. 9. Plasticizer for wlro insulating oonpounda. 10. In traneformore end capacitors. 11. Aa as imprcoiont for poper products. 12. rroosura eenaitlve aealcra. 13. Xo firs rotardont pa iota and coatings. . 14. Inprepient for textiles. 10. Industrial printing inks. ' 10. Stoj^off luoquora for electroplating. 17, Ceranlo, glaze printing. . 18, Plastielzer for uoh.>lt conpoaltlona. 19, In tbs manufacture of dontures. . Booed on our practical experience in the ranufeeturi* and sale of ' nllllona of pounds of Aroelora annually, the point thnt ve rould enpbualza is that workers should not be expooed to Aroelor vapors end thnt the sen working, with Aroelora should obaene "good house keeping" rules about keeping tholr clothing end skins free of the naterlol and avoid ingestion of It. Adequate ventilation has proved suecossful In keeping the atnoaphere free froa barnful anounts of Aroelora around aoohinery and in plants. V^ies you bora bad opportunity to rhi eonelderatlon to our above coa-wnta, plenoe let ua bare your thought a end lat ua know If vre can be of further asaletaaoe to you. . Toura vary truly. P. 0. PenlfBus Dovolopaent Department TRAM 016791 STLCOPCB4025079