Document ppkmEmr18B62jQYBwKVvvGmLB

August 1, 1969 Dr. J. B. Long Manager, Toxicology 3M Company 3N Csntsr St. raul. Nlnnaaota 55101 Osar Jlmt Regarding your request concerning Aroclorr 12^2^/1248. and 1254, I trust the following will aervit Jr our pur r*" Aroclor ____ j Aouts oral LD50 - rat - 4470 mg/kg Acuta skin minimal lethal dose - rabbit - >1260 <2000 mg/kg. Although no akin or eye irritation atudlae were done, we know that the liquid Aroolors are good solvents for the normal fata and oils of the skin. Suffi cient skin contact then could lead to drying and chapping. For this reason we reoommend thet re peated or prolonged skin oontaot be avoided. We do not have Inhalation data. We do not have breakdown producta alnoe theae are relatively stable compounds. Aroclor 1248 Acute oral LD50 - Rat - 12,500 mg/kg Aoute akin minimum lethal dose - rabbit - >794 <1260 mg/kg. A study was made using a 4g (w/v) solution In com oil applied dally for 20 applications to the dipped Intact skin of rabbits at doses of 10, 50, and 100 mg/kg/day. The 10 mg/kg/day dose had no effect on body weight hematology and urine analyses when compared to the controls nor were there any gross or mlcropathologlo findings. MONS 090492 Dr. j. B. k_.ig August l. 1969 rag* Two Aroclor ^BBR (Continued) The 50 mg/kg/day dose produced generalized inactivity, weakness, laaaltuda, and loaa of appatlta. There war# no algnlfloant local akin reaotlona. Hema tology and urlna analyaaa were comparable to the oontrola. dross pathologic examination revealed liver diacoloratlon. All other tlaauea and organa were comparable to the oontrola. Nloro pathologic examination revealed moderate hepatic neoroala. All other tlsauea and organa were comparable to the con* trola. The 100 mg/kg/day doae waa more aevere but comparable to the 50 mg/kg/day doae with regard to hematology, urine analyaea, groaa and micro pathologic examin ation. We do not have Inhalation nor breakdown product data. t99},F. tffft Acute oral LD50 - rat - 11,900 mg/kg Acute akin minimal lethal doae - rabbit - >1260 <2000 mg/kg. 20 Day Subacute Dermal - Rabbita Doeee ware 10, 50, 100, and 200 mg/kg/day. Tha 1050 waa 75 mg/kg/day. No adverse reactions Including hematology, urine analyses, gross or mlcropathology, except after ten days soallng and wrinkling of the skin, was observed from the 10 mg/kg/day dose. The 50, 100, and 200 mg/kg/day dose produced gener alized inactivity, weakness, lassitude and loss of appetite. The 200 mg/kg/day dose produced death before adverse skin reactions were observed. At the 50 and 100 mg/kg/day levels, there were skin reactions which revealed scaling, wrinkling and flasuraa. At these doses there were no effeots on hematology or urine analyses. Oroas pathologic examination revealed liver dis coloration. However, all other tissues and organs were comparable to the controls. MOWS 090493 Dr. J. S. ~jng Auguat 1, X969 ri|< Three 20 Par 8ubacute Piml ^ Habblta (Continued) Hieroeaopla axaelnation revealed moderate liver neoroala. However, all other tlaauee and organa were comparable to the controia. We do not have Inhalation or breakdown data for thla product. If your weather haa bean anything like oura during July, you wouldn't aak auoh a allly queatlon. Beat regarda. Sincerely, William H. Hunt, Fh.D. Toxlcologlat, Medical Dept. Ju MONS 090494