Document ppemp9rao5Q9DGOM62Bn1Km4D

February 16, 1943 Dr. H. H. Schrenk, U. S. Bureau of Mines Experimental Station, 4800 Foirbes Street, Pittsburgh, Pennsylvania. Dear Dr. Schrenk: In response to your letter of February 5, I am sending you herewith a list of subjects and speakers which we offer for the program of the meeting in Rochester. I am entirely willing|to leave it to the program committee as to which of these papers will be most acceptable. If you are short of program material, we could give all of them, although, of course, you will not want two papers from the same authors. (I refer here to the two offerings by Deichmann and his associates.) Just a word of comment on these several papers for your benefit jin making such selections as may suit your program. The papeb offered by Treon on the group of cyclic compounds represents for all practical purposes the completed results of a rather comprehensive study of these materials. You know quite as well as I and perhaps a great deal better, the practicajl importance of this subject at the present time. The paper offered by Largent on the fluorides is more or less 3elf explanatory, but it represents an estimation of the fluoride I exposure in magnesium founding based on urinary excretion of fluoride. The paper on pentachlorophenol, if chosen, will represent a discussion of the toxicity and mode of action of pentaohlorophenol together with some reference to its fate in the animal organism |and will be a general summary of our observations on this compound and its sodium salt. The detoxification of organic compounds is the result of a study, by no means comprehensive, of certain mechanisms, par ticularly the conjugation of toxic compounds and radicals with glucuronic acid or with sulphate. The paper which I am offerlngh&s to do with balance studies on a human subject, in an effort to determine the degree of absorption from the alimentary tract of three different alumi num compounds. Clinical observations on the subject have been Dr. H. ft. Schrenk - (2) - February 16, 19^3 carried on along with the metabolic observations. I have chosen this subject rather than an extension of the work on the metabolism of lead, partly because the data on lead can not be Worked up in time, and partly because I do not want to confine myself entirely to the subject of the lead meta bolism | I am very glad that the meeting is to be held and I heartily approve of the arrangements for combining the three meetings. I can ill afford to be away for four days, tout the character of these meetings in the past has been such that I can ill afford to miss them. Therefore, I shall probably make it a point to be there the entire time. With kindest personal regards, Sincerely yours, RAK ef Enc. Robert A. Kehoe, M. >. Papers submitted for consideration Firoffl The lettering Laboratory of1 Applied Physiology Program Committee - A.I.H.A. - May 1943 An Experimental ?tudy on the Ingestion of Aluminum Compounds by Robert A. Kehoe, Jacob Cholak, and Donald Hubbard The Physiological Response of Animals to Cyclohexane, Methyl- cyclohexane and Certain Derivatives of these Compounds II Inhalation * by Joseph F. Treon, William E. Crutchfield and Karl V. Kitzmlller Exposur^ to Fluorides in Magnesium Founding and Its Significance by Edvard J. Largent (1) The I Toxicity and Behavior of Pentachlorophenol In the Animal Organism by William Deichmann and Girard Thomas (?) The (detoxification of Organic Compounds by Conjugation with Sulfuric and Glucuronic Acids by William Deichmann 5 5 7*7 ~T N 24944.01