Document ppXD1dMd8yD1Z2QBDJpeVXwY7

. SPOL :: Ar 22671627 . CC: JT.. FA,. DFoosutgehrty# o2r..A.V. scL.hmiPdower RENi, TTaaytloerr PJ.. TF.hisTthloemtaosn RFeilJe.'1.zi1p.f7e.l3 August 11, 1983 PERSONAL AND CONFIDENTIAL 0: TM. KEW. , FROM: J. Go LosonavoQ. 0. UPDATE ON THE C-8 BLOOD SAMPLING PROGRAM Pawder/DAinspoevresrailoln darnodpFEiPn bOlpoeordatoCr-s8.levTehliss statistically significant. In Table 1, it dirsopobsienrvbeldoodfnC-[8EFlLeOvNeSlsFinise can be noted that 16 out of 22 FinineadPdoiwtdieornaDlistpweorsOipoenratOopresraetxopresrieexnpceerdienncoedchaangder.op iTnheblfoooudr Cr-e8maTienvienlgs. Operators experienced increases. enced a IndroTpablien b2,looidt cCa-n8 lbeevenlost.ed tThhaetsi1g4niofuticaonft 1d5owFnEwParOdpetrrateonrdss eexxppeerrii-enced by both groups of Operators are very encouraging. half-liDfaetaofonC-8indinivitdhuealbsloowdho(eif.et.TEthFeLONtimeinditicattaeketshatto trheedubcieolbolgoiocdalC-8 Tevel by 50%) 1s approxinately ta years. DISCUSSION D(iFslpueorrsoipToohnelymaaentrdtsacFhELePadbOopTreaarbtaloterosyrscA.onnatlayBislniosodblIoCno-fd8orCdm-aa8ttaiodnawtearReetfororibetvaTaiElnF)eLdOpWrforgaFrmianmet.hePowFAdLleArI/R BFlLoAoIdR uspamptloes7/w1e4r/e83anaraelyziendclubdyedtheinC-thisspercepiofritc.metOhnoldy,datDaataon rOepceorradteodrsin wThiostehdavesawmoprlekeddatiensTEarFeLOWiPncaltudleedasstinc7e30ndeawysOpeasratoofrsthewilflirsetxpoefritehnecetwioncreasing blood C-8 levels until an equilibriun level is reached. 838-26048-1 2 a I5E . EID079277 vOUuL . T. H. KEW -2- AUGUST 11, 1983 e1x.1perpipemnBclteoodod25an.C0-8ovpeTpremavleallnsd 1af3ov%rerdarFgioenpe 5in.P5obwlpdopemord/D(Cis-se8peelrTesavibeollnes O1p)o.evreartTohtrehsese prOaapsnetgreattwfoorrosm yaenadrsa.vera"Bgleood1.C2-8pplmev(eslese TfoarbleFEP2).OperTahteosresOpreanrgaetorfsromex0p.e3r6ienpcpemdtoan3.o7verpaplml $22 Gop in blood C-8 levels over the past two years. the blooAdpaC-f8redd-etcreteasste Cally significant. As ewxapserpieernfcoerdmebdyomnosttheofblotohde OC-p8erdaattoarstoisdestteartmiisntei-if a result, the decreases were found to be statisti- Craeldluyctisoingsniafirceannto daotubtthedupe=to0.0e5ffloervtesl.madeThebsyeTEsFiLgOnNificCaonptolybmleorosd Ca-n8d Polymers business teans to reduce C-8 in air levels. hinagveblionoAcdlrteahCso-eu8dg.hdecmraInenyatseeorsfe,stthitenhgerlFeyi,nearaelPlofwofduoerurr/ODOpipeserpraeatrtosorirsosnwhaOorpseeeraitbnolvroosoldveadrCe-8wietlxhepveewrleisiegnhc ahiranevgaeCb-weBeernein afntohauelndyzietndograeetxdciee0en.dt7s9tmhhpeobodA.EaLn.d L0e.vT8ewol4smspaobmf.plCe-sH8ouirsneeckeaeinertpliyonugtcsoailndldeecwttoehrdiks ihnhaobtoidhtiss ainroutnhdisthaereaouatrseidelesosf tthhaen haoodde.quatFeo.r thAilsarrgeeasoanm,ounitt'osfrpeocwodmeerndweads othbasterved owofrkC-8habbietsrevbeiewiemdprwoivtehd aalnld eSamfpeltoyyeeasndcoHnecaelrtnhedR,uiensameilnyvoAlvuitnogclathvee Owepiegrhaitnogrs atnidonDibespecrosnisoinderPerdoceasssoarsr.eplaIcte'msenatlsoforretchoemeCn-d8edpowtdheart.a 1iquid C-8 solu- due to tBlroaondsfeCr-8odratraetwierreemenotbta(isneeedToanblefiv3e). inDdaitvaiduonalsthwehsoe left TEFLON individuals bilnodoidcatCe-8thlaetvelosn tbhye5a0%v.eragTehisitistakceaslleadpprtoheximbaiotleolgyictawlo yheaalrfs-litfoe.reduce J6Lisde Attachments 838-26048-2 R 000232 EID079278 3 . TABLE 1 TEFLON FINE POWDER/DISPERSION OPERATORS :8 BLOOD SAMPLE "RESULTS FIDARTSETOF SAMPLE. vi482 2/18/82 0/8/81 8/7/81 wys 282 8/12/81 4/2/82 1/7/82 4/6/81 y1y82 12/30/81 8/19/81 3/26/82 12/2/81 sez mem 7/16/81 4/6/81 33/82 2/9/82 10/9/81 BCL8OODIN (PPH) 26.0 24.0 11.0 9.4 8.2 7.0 6.9 5.6 4.4 4.3 3.9 3.6 3.5 2.9 2.8 26 28 2.5 2.1 1.6 15 13 JDOABYSATIN SAMPLEDATE 9,358 2,332 9,260 2,319 5,813 1,989 1,763 8,311 5,765 857 800 962 Ei 8,202 2,256 1,621 5,652 1,705 918 5,880 70 1,803 SDEACTOENDOF SAMPLE 1/12/83 2/17/83 1/3/82 8/6/82 9/29/82 2/10/83 7/15/82 3/2/83 17/83 5/12/82 3/10/83 12/21/82 8/17/82 3/18/83 12/2/82 4/6/83 6/17/82 6/30/82 19/82 3/22/83 2/10/83 10/6/82 BCL8OODIN (PPM) 20.0 25.0 8.2 7.9 6.5 77 5.9 4.2 4.9 5.6 3.6 2.7 21 2.8 2.8 2.4 18 2.5 1.6 15 12 11 JDOABYSATIN SAMPLEDATE 9,721 2,696dr 9,651 2,743 6,176 2,353 2,080 8,645 6,130 nt. 1,28 sf 1,164 1,32 1.23 8,599 2,621 2,012 5,988 2,054 1,206 6,260 1,13 2,165 X=6.3 pm X= 5.5 ppm 126 oouutt ooff 2222 eemmppllooyyeeeess eexxppeerriieenncceedd ndoeccrheaasnegde bilnoboldooCd-8C-le8vellesv.els. 4 out of 22 employees experienced increased blood C-8 levels. 2 TDeevcerlea. se in C-8 in blood levels is statistically significant at p = 0.05 g 838-26048-3 EID079279 000223 : TABLE 2 TEF FEPLOPEO RATONRS C-8 BLOOD SAMPLE RESULTS FIDARTSETOF CB-L8OODIN SAMPLE (PPM) 4/7/81 4.5 2/2/82 3.1 41582 2.1 vase 1.8 12/16/81 1.8 47/81 7 yas 12 y3s2 0.95 10/28/81 0.86 10/15/81 0.75 yume ose 8/26/81 0.51 ose 0.2 8/28/81 0.41 2/8 0.38 X= 1.4 ppm DJOABYSATIN SAMPLE DATE 1,284 9,438 8,917 9,29 1,977 827 732 5,813 899 1,807 5,417 891 2,387 861 1,927 SEDACTOENDOF SAWPLE 4/22/82 221/83 4/14/83 1/26/83 112/83 9/15/82 10/9/81 4/26/83 5/16/83 0/4/82 3/17/83 7/29/82 5/16/83 8/26/82 10/26/82 CBL8OODIN (PH) 3.7 2.8 15 11 16 14 1.20 0.79 0.75 0.72 0.44 0.48 0.39 0.46 0.3 T= 1.2 pm DJOABYSATIN SAMPLE DATE 1,664 9,822 9,281 9,613 2,369 1,353 903 6,208 1,464 2,171 5,782 1,228 2,832 1,224 Jour 2,290 14/15 employees experienced decreased blood C-8 levels. Deevcerle.ase fn C8 in blood levels fs statistically significant at p = 0.05 838-26048-4 . 000224 = EID079280 . TABLE 3 EMPLOYEES WHO' LEFT TEFLOW JOBS CL-E8FTITNEFBLLOONOD W(PHPEMN) CA-8LATIENRBLDAOTOED A(PTPM) BDEATYWSEEENLASPASMEPDLES REASON FTOERFLLOENAVING 19.0 16.0 20 1 Retired from Company 3.8 2.2 we 280 Retired from Company 21 22 0 3m Retired fron Company 0.57 oi 2S 30 aTnroatnhsefrerrWeWdDtiovision 0.14 0. 04 759 TarnaontshfeerrrWeWdDitovision *Tahndiswi5l%l ibnecrceoansseidfnereCd-8asbloaod0%ledvreolpsin1sblloiokdelyC-8d.ue to analytical error B2.i1oloygeiacrasl. half-11fe of C-8 in blood based on these 5 data points 1s 838-26048-5 ~ vi0R25 2 ? EID079281