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ARARGZH A> fl ] - 000230 |. |: > || i | | | | | ) ~. ARRA6 - S424 te co EstimatingExposure, `and PoteLivnerEtffeictsafrlom cotoofrifmoaioynofaappgropieatensnyses .A `ofhistorical surveillancedata Introduction Gana ering rlioosaves feu---- ceotcm.p)iosunbadsseidnodnuctehearbeisoullotgsiocaflrroedesnptotnessetkinngo.wnIna. speroxisomeproliferation. Research with chemicalsknowntoproducethisresponsesuggeststhatlongltieverrm,apdmianinstcrartiaoenndtatoesrstoid,se.nHtoswreevseurs,oitnhtehreddaetvaeilnodipcmaetnettohfabtemnaingmntauymboresaotfltithlee riskforoccurrenceoftumorssincemanis alowrespondertothis classof chei.m e., pi eroxc isoa meprl olifs erat, ors.However,otherlivertoxicitymayoccur in manthatisindeopfpeeroxnisodmeeindunctiton, Baones xpere imend tal data,changesinliverfunctionmaybe ameansofdetectinghumanbiological restop theo sesn hems icae ls. Additionalconcem with thesecompoundshas been thatthese materials havebeendetectedinthebloodofexposedemployees. Exposurepotentialisby ti henbhoavoelrrdysasklit onwyclioyn.toactntis.eIsttiismkantoewdtnhtahtatthtehhesaelcoempoofuCn-d8smaaryebeloiamisnlaotendgfarsom3- Senn 5years.Atpresent,therearenoavailablehumandatathatdemonstrate iHnocwreevaesred,letvheerlesroefmbalionosdcoorngcaneomfiaubcoruitnetshweiptohssdiibislcietmyiobflesaudcvheefrfseechtesa,lpatrhteifcfuelcatrlsy. withretgofivaerfurnctidon. In 197th8 e3,MCompanynotifiedDuPontthattheyhadobserved elevatedorganic fluorinelevelsinthebloodoftheirworkers exposedto ammoniumperfluoro-octancate.Although the specific3Mproductwasnotused atChambersWorks,Chambers Worksconducted aspecialbloodmonitoring `programin 1978-78forourfluorosurfactantemployees.Organicfluorinelevels in tAhsebalrooosudwt,atrheefboluonoddtmoonbieonroindigfpfreoregnrtatmhawnatshteeWrimlimniantgetdoinnco1n9t7r9o.lgrouplevels. In 1999,ChambersWorksconductedanotherspecialbloodmonitoring programfor a subsetof our fluorochemicalsemployees.Organicfluorinelevelsin thebloodwerefoundtobenodifferantthan the 1978-1979ChambersWorks ` lavelsandthe 1978-1979Wikningtoncontrolgrouplevels. `CompanySanitized.Doesnotcontain TSCACBI 1 000231 . : ~~A. . ! ) BD | . te Pues he ofmedicaland exposuresurvellainncae minaafrokkrfemorartsdiaonreawvetleolsqallufaceonotaapcteidcdi,sunseauspcgeh.asWeuxthrpvaoiesnlutlorhaaennceeeaxvpperloossg.urIranomamacradkneprrasoavsntikddeavvofaalolusunaattbil,oens canbobasedon humandata " objectTihveiss: proposaldescribes abomonioringprojectwiththefollowing 1.bElsotoadblpisehfprleo-rploaoccamieanntbloeaavsteelel,nlevelsof ordion nbloodand - 2. Maovenryitomrownotrhk,placeexposurotoC- byrepeatingthebloodsampling 3. aCnomdvpieartseonalmmoennktoorriinnggrreessuuss,wih Indust Hygien werkplacs sic 45.. EEsstaablbilshhrlatvoolfbboigoeraiscacnculomnwfuoCrl-keairnstwboyirkcoeornnst,inuedsrvoance 6.tChpoeerrobulooarmtoaeorcdktaeotrnasoooanfteebxlipovomlsa)ru.kreer(sloofrfdfsecfton(isnorbulmooidvearnednbzlyomoedlevels)with 7InCE cloudnintgsomoun olrinngdodhiiiseton6re sy.;commpalestass blrooddcousrtc , asso orpvotaenetiyal Approach bperlooproesweAodrC=k8bsarugrcivynec,lilhianegcpaerbpoirgorgarmoascmooaotlntoCohpbarmee-beexrtpasotWseoudrr.ekbsIawstiheellpitrnaoeksjaeodcnvtbasanattphaptgrheoevofetdhe bsihoomaurdkceornstoaifnetxhpeofsolulroewainngdvoafriefafbelcetsw:ilnotbe compromised.Thedotamatrix 21. Nsasmne 43..DDataoooftfCHe8oetasknation 56..CDuarleenottBTiatshkAssigobtnle,mtaesk nnamte) - 2 : 000232 B K Fa @ = |! | |fr 2D | || | || I | YT ~~ 7 87..TSotavnadsapradIntHinmtasek aosfexuposruree(prseferablypersonalmonitoring, doumkmaarleecxaptoasuored sc) haassess mero 10.ULasboooraftpooryrresupsrooftC-c8h,ofsluiogrindee rsfon, enzyme measurements. 1 ined 2 stldatavariables. chi enzym"eTmheeparsoutroecmoelnwtisl,parnesdcarriebeadoartpaecroslolnecailomnoanittomroirnigtaytienttehrovrawlsefeoklryi,voerrbmweeaeskudryeinmteenrtvasl,s,lforngawpiotrhotdheotfotoanlenyuemabre.Trhofeirnadnivgiedauanldsivnatrhieanpcoetoenfttiahlelsyo. eaxnpdolsoeredpoppulaitiodn,weivlalpmuroeviiindceooangtoilnoudiionngdtihgceadtaiiotnaoccfowlhlaeectthlieornt.here scincal highly sensitiveIt,shtohuelydabroenroencsopgenciizfeidctahnadtowfhpioorvpeorsietnizveypmreedsiacrteivgeevnaelruaelliny imdeeantsiufryiendgterxupeosoucrcuapiastlioown,atlhevperredviasleeanscee.o(ifnolocwc-ruispkawotrikpolnac-eas,swsihveoercrediiasteaesde V`emrayylboaws.olInotwhetshacttihrecpuomssittainvceepsr,aodtihceirvceavualsueesoofftihveesrcdryesefnunicntgitoensatrmeatyhaelmsoorbse bafitkteelryireesaosfonafnoyrazbmnetoersmtaslasrcorieneanxipnegnrseisvuolatns)dHhoawveevtehre,atdhvearwitdaoglyeoavfalialragbe'le fboordcioemspoafrgiesnoenr.aIlpnoapduldaotinontdhaotaavaanldabaistsyoocifaptreed-Texoprosaur"evleavleulossvthlateanraebulseeful t`heaecshtCud8yiesxfpoosmeedawsourrkecrhatonsgaerivnetahsesheibsloowmnacroknetrrsoolvaesrttheep.rimarypurposeof _ . atnd toheiondunsotrrihsaohycgoiecneimnonaaintdosrsiunbsgmdianstas.ioTn!hoorsCorlporoateoEfpidemieolgosgyales doPironggratmhewaislsaessssummeenrteosfptohnesdeisbclryifptoirvceosntsattinsitciicsnogtnhtehaenpaolpyuiaidoantafrelseausnadtthe `ondofEtmhpelforysetyeosavriolfdbaotaasckoleldectotipoanr.icipatsin adescriptiveepidejimiology ipnromjeesctstrhaattiwilbboeoddircehctaendgteosu.nTdheirssctoamnmduinngiwchaethewriolrnboodtoCn-3e benxpoorssuresressutlte personnel corporateepidepremsenit oaonslweroquegstioins.sUpton oO`fccotomhupelpreaetsoiuonlnatoslf.HtQehueaeptsrhtosjieoacnlts,.ctohenceommpilnoygemeesdwiiclallbseunrovteilflieadn,ceinwiplerbseohnaannddliendbwryitsihnge, i1n0tcomonmaSpdeaivarleeartsahwleobriooopteaartsstihesdatiapnncraeonoofcrtoaatltadloofsluedoriinemiaonltsshcertbeleoniondgwsiittuhltdryhaoetstpHeaessckeioelsloLtab | | 3 `CompanySanlized.DossnotcontainTSCACBI 000233, L o | 2, frfomlthuebolorodoatnchaaltyh3sMieshaamfdtiridrceenptaefaietlde.dTorhaledporseleismsionafrayrsicnrdeiecantiensgitnhfaotromuartion productsdonotabsorbintothe blood tothesamehighlevelnorpersist inthe bloodcomparedwiththe 3M specificfluorochemical. BD . i lo. | ` 000234