Document ppL3N6NBYpBpr6pbVqemVayma

D> ~ AAsuoerrC.hChaarrlleessB@eeppoammaai~Lleeppae.ggoovvoonn 00441/1111//22000000 0011::4400::3355 PPMM ph ery To: Dan C. Hakes/US-Corporate/3M/US Ee c~: Hernandez.Oscar@eparnail,epa.gov patel.neil@epamail.epa.gov 31 Penberthy.Ward@epamail.epa.gov Subject: follow-up on perfluorochernicals request rr Attn: Bill Weppner and Dan Hakes, 3M I Dear Bill and Dan, oITuherfoppurenirdofyrieiusrtrytyoencrenhdeseaetmydei'scsafolporshronase5ubbeSmciaiislsselcstuiouosnsna-ecofodfuflfvtnoeissnottyhcSedalaosptaaialnTginnetsSo3soMe?ssgsheasprooposefsvnseAessaPssnTiidIconnclo7,ora.rri2S0fc0hyo0no.tsrroeomleAaooofwnne the perfluorochemicals as discussed in my email message of April 7, 2000. As we discussed: BLSEIE L TtL es J A 8 Ce 2S0 A >3M need not resubmit copies of sSndies already provided to KPA (e.g., under BE THT ER RE TSCA 8{e), under FIFRA) although we do request that you provide a comprehensive bibliography of the studies already suhmltt~d so we can check this against our holdings. (@ ceome smsmsyesatessss aa ovyn epi >Copies of acute systemic toxicity studies can be limited to the key or erotical EE Re ee, studies as described in the Data Adequacy and robust summary guidance developed i od EA EN for the HPVChallengn Program. Under this approach all studies must be cited in a bibliographic listing although full copies can be limited to studies which serve to identify lowest (i.e., most toxic) lethal dose values by different r{Touiusvtiiennsgg tothrhee (ss2)aammeereprroooruutttee))obssseuurbbvmmeiidtttteeedfdfeuucnntddseerrwh((iI1c)).h. differ from those seen in studi-es CALTE LnAyTo ASL Ss opwee >Skin and eye irritation studies can be handled in a manner consistent with that ee fa et outlined for acute systemic toxicity (i.e., submit copies of the key or critical INERT studies which serve to set out the irritation potential of the chemical and other irritation studies which show effects which differ from those reported in submitted studies). p To rET Speyattgsederi,SSt AgreAAe >The initial request is generally limited to studies conducted during or after a 1976. For studies conducted prior to 1976, we ask for a bibliography listing A ee EaE s TiSEkAi rE all studies and for ull copies of studies in the following endp0int areas: genetic toxicity; subchronic toxicity; reproductive toxicity; developmental toxicity; immunotoxicity; uptake/metabolism; chronic texicity/carcinogenicity; neurotoxicity. RtoI ir SA >Regarding exposure information, we ar~ most interested in receivin~ information E EE Ea ai a mn SnerLwes and data of the types fonnd in the Use and Exposure Information Profile (UEIP; a i El the UEIP has been used to support SIDS assessments in the US) and information on ETE Ei SRL Se Toy results of exposure or monitoring studies (human and environmental), including I RE TE eT, full copies of studies where available and including details on procedures and methods used for sampling and analysis. We wil~ take a close look at the white E HT,R RTT, paper on exposure previously provided by 3M and get back to you with additional points where relevant. TT - oo TTaabb336622 11666655..00000011 mre. | onswears Exhibit 1665 3M MN02457016 oo shpat ro, ve xen uc by rid2, 300, ae 4 cep of >Regarding PFOS, we request that 3M by April 24, 2000, send full copies of phFCPshuthhaaumaaidrarnnimmnie~mssbbcctiiooeookkyr.-iiennoleeaaatrttnnhiliddocendssgsoscctct((uuoaippnnnaadrccttelliipsuuooreddnnolsiasdndnl]guygctmpmttiohhroveneoaeizttoirrocoetesrrsosliiuxusnnillcgyttisstto((yoose,ffarslppldteteoehhcceevwiiesalt2U2losl--lpyyggmeeteddnnonoeeetcterraaaaualiitttlliilsecoutnnaotxooiefsscttiauaustmdndtymyyau,lldsyyaieetneaiiasiclcyyaaaeslsliirsse))a,,dyaanndd pECcrhrhoeorvmviiodisnetidre)yad.3mectuPvhteooirrdisncouaurasrndddiiinsssmctcyuuodsryAssiipopcrnrniottcoh7hceeocleddsaiaitt]aetofmfaooerlrslesousuwsubebaumsiwigisslstlioioobnenevoaoflfeunattthhdeeeaoosdttthhuederir6esRiLnrEaffLlooLrrremmaaa2d8tt,yiioonn on PFOS as outlined in my April 7 email message will be extended to April 28, A2>R0Re0egT0ga.arrTddiinnggococettbhweehsritsseuullftnooannpaaeztreedd(3pp6eecrsiftsliensuoonrroaocechtteemmIitnceaacllyssAaappprppieeaarr7iinneggmaiiinnl)TTaabbSllWeeLoI1 ooaffte3MdM7?5s0 MpParrroocvvhiiddeei, tthh2ee000rreewqqhuuieetssetteedpdapiiennrffoorr(mmasaactiidooinnscbubysysWMeoadyyin1193,,my22A00p0000r..il 7 email), 3M is asked to sinormasion on 718, + castonyaces exlliscemienli,t copied to be >Inormatio~ on PFOA0 a carboxylated perfluorochemical, is requested Lo be provided by May 26, 2000 (rather than May 19 as ndicated in my April 7 emeil Eierriagoeer.kineodunhaossTeecbheSma)bm3i54te(eosodek MBilap)plo3s3si3ke1Loa8yooxuheeCroeripsuentaTheacuprrisceed in message), and should be submitted as supplements to your company?s prior prenppestyion submissions under TSCA April 7 email message). 8(e) 394 (not 8(e) 373/374 as otherwise discussed in my E2ERExx0Acc03eee00ppettSemomsaapaiiss1lSeacdriicoessorccnneutuidsisosnsaeuGetdeodosvatsbocooivvaaoeeppn,,ppsllyryctheheepKteoocKrdteothiqhqiiunusseegssttehrsseqiqusauaenenrsddrcLogGbaubuysiyiddtaaEi.nnPAccAeDelffpepoorrrsrooevvsiiniintddfcoeeoordrdrmmcaaiiittcnniitoommnnama..syy AbAppy1Irrfiicllyyaoontu7u7,,] or Than have phone oa 200374m T shank you In any general questons regarding (202-260-3749). I thank you in advance Tox this request, advance for your coperation. please contact me your cooperation. by email or GisCChhecaemermtelicsceaasraltwM..CcooPwAnvouteleeersrrsou,,tltiDDDDoiiinirvveeiiPccssettiiooooovrrnnaction 13atoxic CHPTS/ETA Office of Pollution Prevention and TOXiCS!OPPTS/EPA 11666655..00000022 Tanz Tab 362 I3MM_MMNN0022445577001177