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FILE NAME: Kent (KNT) DATE: 1955 DOC#: KNT134 DOCUMENT DESCRIPTION: Journal Articles - The Journal of the American Medical Association THE JOURNAL nmmL Tlosdbu^ lLanJtLc (ih^ Qjuul 6-10, 9SS T*** issue ce e d s '6 5 .0 0 0 Coo.e American MedKicaTHE l Association APRIL 9, 1 9 55 ORIGINAL ARTICLES C O RR ELA TIO N OF FIELD SIZE AND C A N C ER O C IO A L DOSE IN X-RAY TREATM ENT OF SKIN CANCER K. 0 . A . A llen, M .D .. on* ) . H. Freed, M D , Denver TREATM ENT OF PSYCHOTIC STATES W ITH CHLORT.OM AZINE Oowgfos Goldinan. M .O , C in c in n a ti C H LO R O P H Y LL SO LU TIO N IN D EO D O RIZATIO N OF ADVANCEO CARCIN O M A OF H 'A D .AND NECK A . H Kutscher, ) D .S .; Robm ftonkow, D O S , m D , J 0 . Pire. D O S . . E V . Zegattiii, 0 .0 .$ , end N. W . C hiffo n, D O S , N e Vork NEONATAL TORTICOLLIS W 8 K ie te w e tttr,* M :0 ., f . K . H elto n , M .D .; V . i . P o llo d ne. M .D ., ond C . C. Koop, M .O ., P h ila d e lp h ia JAUNDICE CAUSED BY CHLORPROMAZINE(THORAZINE! L . R . lo t t v i. M .D .; K . a . H u izen yo , M .D .; M . K . Stauffer, M .D , H . P . Rome, M .D , end i. C . Com , M .O ., Rochette*. Minn. P ED IA TRIC RESEARCH IN THE AGE OF TH E COMMON WAN AND THE EXCEPTIONAL CHILD C . A . Jo n evay, M .D , Boston PSYCH OLOGICAL FACTORS IN MENSEEKING SEXTRANSFORMATION F . C . W orden, M .D , and J . T . M a rch , f h .O ., Lo t Angeles CLINICAL NOTES CH LORPROM AZIN E IN THE TR EA TM EN T OF EM OTIO N ALLY M ALADJUSTED CHILDREN . R . 1. C e ttk i, M .D ., D an ville, Pa USE OF FLUDROCORTISONE A CETA TE IN DERMATOSES R. C . V Rofemton, M .D ., Baltim ore SPECIAL ARTICLE ED U C A T IO N A L METHODS IN POSTGRAD UATE TEACHIN G 0 . D. VeMon, M .O , Chtcego SPECIAL REPORTS Chemical Laboratory A STUDY OF CIGARETTES. CIGA RETTE SMOKE. AND FILTERS N ICO TIN E AND TARS IN M AINSTREAM SMOKE 1271 1274 1279 1281 1286 1289 .1292 1298 1300 1302 1305 U tl E D IT O R IA LS Ulcerative Colitis A Hole in the Pension Umbrella Prevention of Rheumatic Fever 1312 1313 1313 ORGANIZATION SECTION AbBstoraarcdt of of Minutes of Trustees Meetirt9$ of 1314 Statement by Dr. David B. Allmon Before Subcommittee of House of Represento* tives, Morch 10. I95S 1315 Statement by Dr. Leo H. Bortemeter Before Subcommittee of House of Representatives, Morch 10. 1955 131 5 Bibliogrophy on Absenteeism Among Workers 1316 REGULAR DEPARTMENTS Medical News Correction 1317 1)21 Meetin9t Eiommotions and Licensure Magazine-Television Report Deaths Foreign Letters: Brazil: Symposium on Cirrhosis England: Industrial Health and 1321 1)23 1324 1325 1328 Acci dents. Use of Ozytetrocyclirve *n Preventing or Deioymg Jsomaz-d Re sistance. Sterilization Techniques Otfard Medical School. A itifio ol In semination Heolth of the British Army Physicians ond Rodio Perform ances. Soop-Wroppers jig. Health of London. Infection After an infec tion. Death of Sir Arthur Keith Lego) Aid for Patients 1328 Switzerland: World ,,Health Orgomzo- tion (330 Turkey: Pulmonary Hydotid Cysts. Cerebrospinoi Meningitis IWoter- house-Fridertchsen Syndrome!. Corti cal Necrosis of the Kidneys. Ascans Tumor 1331 Correspondence: Hypotensive Reoction Following Use of Penfoiintum Tartrate. Preservation of X.Roy Films. Practice of Medicine Drugs ond Anginal Syndrome, incidence of Multiple Sclerosis 1332 Government Services: Army. Navy, Public Heolth Service. Veterans Administration 1334 Council on Mcdicol Service: Medical Core for the Indigent in Illinois 1335 Bureau of Medico! Economic Reseorch: Current Status of Jenkint-Keogh Bills 1339 f C. Oickinton, Ph.D., Chicago Medicine ond the Low. Selection of Medico! Staff in Govern mental Hospitals . . . 1342 Medical Literature Abstracts 1344 Book Reviews 1354 Queries ond Minor Notes: Insulin and Sugar. Treatment of Froc tures. Inflation of Eustachian Tubes. Normochromic Normocytic Anemia. Eosy Bruising in Women. Sinus Treat ments. Diabetes. Hyperthyroidism ond Tuberculosis. Itch Powder. Prolonged Bronchitis. Seborrhea. Stimulation of Growth. Multinodular Goiter. Cataracts During Pregnancy. Medicated Cleansing Tissues. Ultrasonic Energy. Hypopro- tememia. Dermatitis and Scabies. Anal gesics. Dupuytren's Controcfure. Vsuai Loss lor Compensable Eye Injuries. Menstrual Periods, So-Coiled, During Pregnancy. Tongue Sucking frozen Shoulder. Milk. Allergy 1356 WASHINGTON NEWS VA Funds. Military Training. Mentof Heolth Survey Loons for Health Focili ties. Miscellany Adv Poqe 13 Notional Organizations of Medical Interest Tonics ond Sedatives The Bright Side Inde to Advertisers Adv Poge 18 Ad* Poge 58 Ad* Poge Ad Poge 8718 V o lu m e 157, N o. 15 Published W eekly at 535 North D earborn Street, C h icag o 10, Illin o is. Subscript ion, S i 5. Single C o p y , 45 cents Sixth Edition -- Nelson's Textbook of Pediatric \ m od em reyilm uh m n o n d -r c c o g m z c d <*\ytdlencc? dew giied lo h r ip \ on t rcv;: ' m e*" *n yliilrirt-u ;m<i k -luxt'-N' id a :l;n s '-.pr XVC ( n ^a Vol. 157, No, 15 COMMENT Postgraduate medical education has many unique problems that dictate a need for unusual methods, tech niques, and teachers. The small group-discussion or seminar, though employed only occasionally in post graduate medical education, was ranked highest by phy sicians as a postgraduate learning method. Individual supervised clinical casework, lectures, and panels, and demonstrations were considered next most effective. The present disproportionate prevalence of didactic methods in postgraduate education points to the need for a re versal of present policy to increase the use of participative methods. Nevertheless, didactic methods have a larger place in postgraduate education than in undergraduate medical education, since the physician-student has foun dations upon which to anchor the knowledge he receives. If didactic methods are to continue to play such an im portant part in postgraduate medical education, a more thorough investigation of indirect methods using the mass communication mediums is warranted, since these could result in more economical use of faculty as well as student time. Of these mediums, television shows the greatest promise. It is apparent that no one method or plan is likely to be the sole answer to postgraduate medical education. Peda gogic ideals often come into conflict with practical con siderations. The solution lies in a realistic adjustment of the educational objectives to the limitations of the situa tion, but with full recognition of the fact that the com promises required may result in less than optimal learning potentials. Postgraduate education can also serve as a proving ground for new medical educational methods and techniques if careful evaluation procedures are employed. larTgehley dteraacwhnerfsroimn tphoesrtgarnakdsuoafteunmdeerdgircaadlueadtue,cgartiaodnuaatree, and postgraduate medical schools. In order to do effec tive postgraduate teaching they must spend considerable time in preparation for each session and even more in travel. One of the major needs of postgraduate medical education is to enlarge the teaching force, drawing on such sources as the staffs of large hospitals, research cen ters, physicians in smaller towns, and residents. It is equally important that definite proportions of medicalschool faculty time be assigned to postgraduate teaching, with the full recognition that this is one of the instructors' primary duties, not a secondary chore. Faculty time could be much more efficiently used by the development of a well-organized and coordinated system of all postgradu ate activities within each region. Intrathoracic Surgery.-- In recent years intraihoracic surgery has become so safe that excision of a pulmonary lesion is usually the indicated treatment when surgical therapy is contemplated. Resection has reached this preferential position as a result of improved technical methods, the wide spectrum of protection afforded by antibiotics, the improvement in anesthesia that permits the pleural cavity to be open for long periods without hazard, the development of procedures to determine ventilatory ofupoecratitoivne amndanfaingaelmlyentth.eTbheetsteerhuanvedeprsrotavniddeindg thoef pre- and post- foundation on which thoracic surgery rapidly grew to maturity, one of the most spe W. c tacular Holma r n, e cords M.D. ,in the Prin ann ciple a s lso o f f s P u u rgic lmo al na hi ry s i ory.-- Resect C io ra n, o sTtohoe 1American Journal of Surgery. January, 1955. CHEMICAL LABORATORY CHEMICAL LABORATORY This is the fourth report on cigarettes, cigarette smoke, and filters by the Chemical Laboratory of the American Medical Association. The first report, concerning filler-tip cigarettes raepppoerat,recdoninceTrnhine gJociugranraetlt,esJuCllyaim4,ing9 5to3, cpoangtaein91to7.baTchcoe second of low nicotine content, appeared in T he Journal, July If, If}}, page JOJS. Journ Th al, e F t e h b i . rd 20 , r eport, I9S4, on pag c e igare 67S. tte holders, The laborat a or p y peared work r in ep o Trthede Linabthosrasteor-ie.s was done by Mr. Robert R. Stark of the Chemical Walter Wolman, Ph.D., Director. A STUDY OF CIGARETTES, CIGARETTE SMOKE, AND FILTERS 4. Regular Cigarettes, King-Size Cigarettes, and Additional Filler-Tip Cigarettes The Chemical Laboratory of the American Medical Associ ation has examined a number of the largest selling brands among the regular and king-size cigarettes as well as a number of brands of filter-tip cigarettes that have appeared on the market since othne L'.aeboerfafetcotrsy'soforicgiginaarletrteeposrmt o'koen ofniltetrh-teiphceiaglatrhettoefs. hRaebpitouratsl sm oi...s have prompted the introduction of many new brands of filler-tip cigarettes during the past several months. The methods o f analysis and experimental conditions for smoking have been described in a previous report.1 Briefly, 47 mm. of both the "standard" and "king-size" cigarette were smoked (67% of a standard 70 mm. cigarette and about 55% of a king-size cigarette) using 35 ml. puffs of two seconds' duration taken once a minute. In addition, king-size cigarettes were smoked 62 mm. to a 23 mm. butt (the same length butt as a 70 mm. cigarette smoked 47 mm.). The results of the experiments are given in tables I and 2. Table I lists the type of cigarettes tested, the type of filler used, if any, the physical characteristics of the cigarettes and fillers, atonbdactchoe. Lpeetrtceerns taasgseignoefd mtooibstruarnedsarnedporntiecdotiinneprfeovuinodus ipnapethres have been retained as the first tetter for the same brands in this rbeopliozritn.gTthhee abdrdaintdionnaomf ethdeesliegtnteartseskkainngd-sifzetoanthde flielttetre-rtipsymre spectively. Table 2 gives the results obtained from the smoking of Itnhetadbglaer2e,ttecos.lumn 2, the figures are obtained by multiplying the average number of puffs required to consume the designated length of cigarette smoked by the volume of each puff (35 ml.) and represent the average volume of smoke drawn into the absorption train. This mainstream smoke represents the smoke that would reach the smoker's mouth. Column 4 of table 2 shows the weight of nicotine in the smoke from intact cigarettes and column 3 gives the weight of nicotine in the smoke obtained from the cigarettes in which the filter-tip was removed. The pefefreccetendtagbey trheedufcilttieornisinlistnedicoitninceoluinmnthe5 amndainisstrbeaasmed osnmotkhee difference between columns 3 and 4. In column 9 of table 2, the weights of the tars appearing in the mainstream smoke per cigarette are given for the intact cigarettes and column 8 gives the weights of tars in the smoke obtained from the cigarettes in which the filter-tip was removed. Column 10 lists the per centage reduction in tars effected by the filler, based on the difference between columns 8 and 9. The figures for nicotine and tars in the mainstream smoke listed in columns 3 and 8 were obtained from the short cigarettes resulting from the removal of the filters, and are higher than would be obtained from intact ail-tobacco cigarettes of regular or king-size length, since tobacco itself is a rather good filter. If the fillers of the filter-tip cigarettes were to be replaced by aanmoeuqunat lolfenthgtehnoicfotuonbeacacnod, tthairsstpoabsascicnog wthoruoludgfhiltiet.r Touhtisaficleterrtaining t. A Study ot C n i r c l l c t . Cl ia re ltc Smo te , and Fitters: I- Filter-Tui C ii sr c t t es . * report of the Chemical Laboratory. J A M A 1 5 2 . 9 1 . * 9 : 0 D ul y A) 195) 1310 CHEMICAL LABORATORY' J.A.M.A., April 9, I9SS effect of tobacco is illustrated d table 2 by the Vcing-size cigarettes from which IJ mm. of tobacco was cut and the resulting 70 mm. cigarettes were smoked 47 mm. The amount of nicotine and tars appearing in the smoke was considerably greater than the amount o47btaminme.d from the intact 85 mm. king-sire cigarettes smoked If a king-sire cigarette is smoked 62 mm. instead of 47 mm. (to the same 23 mm. butt length as a regular 70 mm. cigarette smoked 47 mm.), 31.9% more tobacco is consumed; however, the nicotine and tars found in the mainstream smoke are higher to the matostream smoke without the fillers and w itluhe intact cigarette respectively. Under comparable conditions, the pro portion of nicotine transferred from the tobacco of the smoked portion of the cigarette to the mainstream smoke is rather constant. A factor contributing to differences in the smoking of the filter-tip cigarettes was the variation in the fillers of the in dividual cigarettes. There were differences in porosity of the fillers, but the greatest variation was in the length of the separate fillers. The fillers of brand M cigarettes ranged from 10.4 to C oiam o B rand E D t J K Lk a Ut A ik N ik B lk O fk T able 1.-- Moisture, Nicotine l t T ype o F ilter D ate Sam ple O btained C<l)ulby t c r t i l c ...................... C e llu lo s e a c e t a t e fib e r ............................... C e llu ln * a c e t a t e fib e r* ............................... . . A ib e a to s l a m t o a t e d w ith p N |v r.......... A c tiv a te d c h a r c o a l w ith p a p e r .......... S e p t.. lflOt A p ril. 1934 J a n . , 1954 J u l y . ipr#4 O f t ., 1954 N o r ., 1034 Content, J Ac e ra te W eicht o C igarette, G in. 1.031 I jOSG 1.084 1.063 1X72 1.233 US7 1.103 1X84 1.2C5 1.193 1.374 and Physical 1 A vrrif W eight o FlU cr-Tlp. Cm. 0.174 0.181 o.i;<0 0.13G o .m Characteristics oj Cigarettes T o tal Leogtb o l C igarette. Mm. 10.0 09.9 70.0 70.0 09.4 41J 14.4 69.9 43.0 M .O U .0 4.1.0 6 A rarat L eogtb o F i lt eMrm- T. ip , 13.1 13.0 15.0 1U 13.2 CAl rreunr nc -a Icreoce o( C lr rette. Mm. 20.4 W .5 20.1 20.2 26.2 25.7 20.0 W .l UJ 25.4 25.4 24. 8 M oisture lo Tobacco, % 11.95 11.22 10.03 10.54 11.49 11.57 11,10 10.49 11.78 10.11 11.03 N icotine la Tobacco (M oisture* % 2.51 2.04 1.93 2.00 Ml 2.29 1.40 1.78 2.00 2.12 t 3 2.30 Colman 1 B rand a D I j K Lk Ek Ml A ft HOt BU OOc 47 asm. s m o k e d .......... 47 m m . i m o k e d .......... 47 m m . i m o k e d ......... 47 c u n . a m o k e d .......... 47 m m . - o k e d .......... 02 m m . i m o k e d .... 4C7 i garet mio. t e a mc uo t k etdo ....7..0... h i m . 47 mm. l o o k e d ......... 42 m io . a m o k e d ......... C ig a re tte c u t .o 70 mu>. 47 a m . a m o k e d .... 47 mm. rooked...... <7 mm. i m o k e d . . . . 42 am . rooked .... 41 mm. im oked.... 42 mm. amoked.... C ig a re tte c u t to 10 m m . 47 n u n . a m o k e d -- 47 mm. i m o k e d . . . . 42 m m . a m o k e d .... 4C7 l caret mm. t e a mc oo kt e td o --TO m u. 47 am . a m o k e d . . . . 42 a n . im o k e d .... <C7l caarree.t tea mc uotk etdo __7_0 m m . W eight of Tobacco AS mc tou ka elldy {D ry W Ce img h. t) , 0.631 0Itii U.U'JJ 0.571 0.701 n :.77 Oo.-aiti>h O4 0.009 O.GT*4 Q -ftd 0.814 O JIO 0U 0.5CJ 0.745 0 ..Y t u . 11 M m il ' o n T able 2.--Analysis of Smoke from Cigarettes ; A verage V olum e o( rMe aamin* Sm oke j*t C lcarette, >11. 350 375 X* 34 r. xw. 45S 3 4 W eight o f N icotine F o un d lo M atostream Sm oke p er C igarette, M g. w ith Filter-T ip Rrm oved lo ta c t JJ\ IB S 2-34 3.13 2.77 I.A 3.54 5 IlcdtIC. tloo o INn lcMo atiion*e S ms troekaem. % .. 0 ; N icotine In T obacco A ctually Sm oked T h a t fa T rao alerred to M ainstream Sm oke. % W ith FRleltme ro.vTeIdp (M a rt ti 2U O Hi 71 V .V 2.Pt w. 337 1.08 17 457 2.90 19 250 2X9 t) 354 2.13 1X0 34 K 14 372 2.44 1.47 23 19 U 481 145 \: 400 MO 521 11 .2220 14 21 IS 1W 394 2.57 . 0 3 1t 1 8* iO 21 M 41 2.96 Hi 1 .7 0 3 4 8 f .12 rri t.5 5 S' <84 t.C l 77. .W 15 18 1i 14 14 4 9 W right o T a ra F o u o tl lo M ain stream S iro k r per C igarette. Ma. W ith FRi el tteurr*nTe idp In ta c t 15 n \9 .t 16.6 HiO 17.2 11.1 21.0 IS o n .r, 18.4 15.4 1C.9 11.5 IU n15..s4 no 1127..11 It 7 r .j 9 0 13 4 14.1 1 0 .4 U 0 i: i 10 tRl oeod u oe * TMa ma in -la e irta m Sm oke. % 33 to 19 (I 31 than can be accounted for by the extra weight of tobacco smoked. As the cigarette is puffed and the smoke travels through the cigarette, the tobacco filters out a portion of the nicotine and tars. At each succeeding puff, therefore, the remaining to ebnarciccohedbectoombaecscoricishebrurinnednicdoutirnineg asnudbsteaqruryentmaptuefrfisala. Aposrttihoins of the deposited nicotine and tars is transferred to the main stream smoke. It is plain that one cannot have the added pro tection of the extra length of tobacco and at the same time have a 21% longer smoke as some ads for king-size cigarettes have claimed. -. Columns 6 and 7. table 2. show ihe percentage of the total 17.1 mm. long, with an average of 13.1 mm.; brand A fillers ranged from 10.7 to 16.0 mm. long, with an average of 13.0 mm.; brand N filters ranged from 12.3 to 17.8 mm. long, with an average of 15.0 mm.; brand B filters ranged from 8.8 to 14.5 mm. floronmg,'w9i.5th taon 1a7v.e0ramgemo.,f w1i1t.h5 manm.a;vearnadgebroafnd103.2filmtemrs. rTanhgeesde differences arc of little significance when the efficiency of the filter is about the same as the tobacco it replaces, but as the efficiency of the filler increases beyond this point, the variations become increasingly evident. Chemical examination showed that the brand M filter was not -cellulose as claimed by the carton insert. Additional tests indicated that it was cellulose Vol. 1S7, No. is At Ihe present state of filler-tip development, filtering effi ciencies in the range of those found in brands A, B, M, and 0 . seem to be the optimum for a commercially successful product. Striking a sort of balance between effectiveness and a smoke too thinned to please many habitual smokers. The early history of Ihe brand B filter seems to indicate this. These early brand B filters removed about 60% of the nicotine and tars from the mainstream smoke, but smokers apparently found it too difficult to draw through the tight filters and the smoke too thin to be satisfying. Consequently, the brand B filters were modified to their present state of effectiveness. From the tenet entitled "A Study of Cigarettes, Cigarette Smoke, and Fillers," data of greatest pertinence to the physician have been gathered together in the following resume on-' are presented in graph form for ease of reference. NICOTINE AND TARS IN MAINSTREAM SMLKE The recent rise in the popularity of king-size and filter-tip cigarettes may be caused partly by the feeling that these types of cigarettes are giving a measure of health protection to the smoker. This feeling has been encouraged by advertisers who have dwelt on the real or fancied importance of such features CHEMICAL LABORATORY 1311 mouth. The importance of this information lies in the fact that the amounts of these constituents that reach a smoker's mouth are proportional to the amounts assimilated by the smoker. The determinations of the amounts assimiltugd cannot easily be made because of the biological variations among individuals and the -differences in their smoking habits. The amounts of nicotine and tars that reach a smoker's mouth can be approximated in the laboratory by the use of a smoking machine that simulate- human smoking under carefully con trolled conditions. The nicotine and tars in the mainstream smoke (the smoke that reaches the smoker's mouth) have been determined by this laboratory 1 for the best-selling cigarettes and brands for which special claims have been made. For ease of comparison and reference these data accumulated in the previous studies are brought together in figures 1, 2, 3. and 4. Figures 1 and 2 show the amounts of nicotine and tars, re spectively, that were found in the mainstream smoke of the cigarettes tested. Using standard cigarettes, brand D, figures 3 and 4 show the average nicotine and tar contents in the mainstream smoke based on the first five cigarettes smoked through various cigarette holders. The capital letters used to identify the brand names of the cigarettes correspond to the letters used in the earlier papers. *y ,.v I"*-*.- tAV-yjg -Vg-rfi yftyyr.} 1 't ____ 23 wmmmmm Nicotine, Mg. senFtt*.cigareNttiecsotisnmeokined m6a7insmtrmea.mC rsomwokeh aotcfh ecdigabreatrtses.reCprreasyenbt arksinrge-pre/ cigarettes smoked 61 mm. Tars, Mg. cigFa>re(.tte2s.--sTmaorksedin 4m7 aminmst.reCamrosssmhoaktechoefd cbigarasrrtrteepi.resCernaty kbinagrs-sizrceprccisgcanrl ettes smoked 62 mm. 1-------------i1--------------i1--------------i1 Nicotine, Mg. F ig ) -- N ivO tm c m sm o k e d ra w n th ro u g h cig are tte h o ld e rs as ti-K efficiency of he filler, ihe type o( filler material, and the length of the cigarette. Seldom has the advertiser given the information that is of prime importance to the smoker, namefy, the amounts of smoke constituents that reach the smoker's 1 A Sin Jv o f Cicireiifi. CigA/ettc Smoke, tod Filters: t. Filler-Tip C*gAfflics, report of the Chemical Laboratory, J. A. M A. 1*5 2: 9 17 920 U u i y 4 ) 195) 2. Special L o w . N i c o t i n e Ci garet tes. ibid. i 3 2 : 10)5I0.t6 iJui y i l l 195* J. Cigarette Holders, i d d . 1 5 4 : 6 7 1 (Feb 20) 1954. 4. Regular CipAreiiet, Kin g-S ue Cigarettes. and Additional Filier-Tip C if c if ei if t. 'biU 1 > ' n 09 (April 9j |MJS THE JOURNAL (iLnimLVYl&sdw^ (BcaJlml Tbv. 29-(Dsu^. 2,1955 T h is Issue Exceeds 155,000 Copies Americ1 an M edicOF THaE l Association NOVEMBER 26, 1955 ORIGINAL ARTICLES CIRRHOSIS OF THE LIVER TREATED C . 5. Davidson, M .D., Boston W ITH PROLONGED SODIUM R ESTR IC TIO N S ...........1257 IMPROVED APPROACH FOR POSTERIOR UPPER TH O R A C IC SY M P A T H EC T O M Y ................ 1261 H. J. M acKay, M.D., Seattle S C IE N T IF IC BASIS FOR TH E SU RGICAL TR E A T M E N T OF CORO N ARY A R TER Y DISEASE 1264 C . S. B eck, M .D., and D. S. Leighninger, M .D ., Cleveland D IFFER EN TIA L DIAGNOSIS OF C H EST DISEASES........................................................................................<. .1272 A . L Banyai, M .D., Milwaukee PROBLEM OF EC ZEM A .......................................................................................................................................................... 1275 Ralph Bookman, M.D., Los Angeles TH E G EN ER A L PRACTITIO N ER AND TH E DISCHARGED M EN TA L H O SPITA L P A T IE N T . 1278 \ K. E. Appel, M.D., and Albert Scheflen, M .D., Philadelphia PAIN IN TH E NECK AND SHOULDER, COMMON CAUSES AND RESPONSE TO T H E R A P Y .......................................................................................................................................................................1282 E. M. Krusen, M.D., Dallas, Texas FURTHER EVALUATION OF HEATING BY MICROW AVES AND BY INFRARED AS USED C L IN IC A L L Y .....................................................................................................................................................1286 G . M. M artin, M .D., and J. F. Herrick, Ph.D., Rochester, Minn. CLINICAL NOTES , ESCHERICHIA COLI MENINGITIS IN FIVE-DAY-OLD IN FA N T...................................................... 1288 ... , ' i . H. S. Gordon, M .D., and Julius Aronow, M .D ., Chicago ` A B S C E S S OF THE EPIGLOTTIS.............................................................................................................................1289 I P ? ' ' V v N. C . E. Raim, M .D.; Jerome Raim, M.D., and Louis Lytton, M.D., Miami, Fla. f jSPECIAL REPORTS Council on Pharm acy an d C hem istry NEwt'AND NONOFFICIAL REMEDIES................................................................................................................ 1290 ^ C o m m itte e on Cosm etics I `` H erb ert Rattner, M.D., Chicago, and C. R. Rein, M.D., New York TREATM ENT OF ACNE SCARS BY DERMABRASION..............................................................................1299 EDITORIALS Statement? by the Board of Trustees_____1302 Second Injection of Poliomyelitis Vaccine 1303 Dermabrasion ............................................ 1303 THE 'PRESIDENT'S PAGE Los 'Angeles .Convention............................... 1303 ORGANIZATION SECTION A Monthly M essage.,.;.......................................1 304 Study Conference on Legislation................. 1305 The Boston M e e t in g .:;......................................1 3 0 5 Federal Medical Legislation............................1305 CODUENFCEILNSEON NATIONAL Results of Survey of Physicians Separated from Active M ilitary Service.................... 1306 REGULAR DEPARTMENTS Medical News ......................................................... 1310 Correction .................................................................1316 Meetings ....................................................................1316 Examinations and Licensure............................ 1317 Magazine-Television Report............................1318 Government Services: A ir Force. Public Health Service. Selec tive Service System. Veterans Admin istration .................................................................1319 Deaths ..................................... ............................. 1320 Foreign Letters: Brazil: Pulmonary Syphilis. Schisto somal Myelitis ............................................ 1323 England: Lung Cancer, Polluted Air, and Smoking. First Seven Years of National Health Service. Hypophysectomy for Diabetes. Hernior rhaphy as an Outpatient Procedure. Osier Memorial at Oxford. National Health Service in Northern Ireland. Influenza in the United States and Great Britain. Compulsory Hospital ization for Tuberculosis. Harmful Effects of Exhaust Fumes. Tubercu losis Due to Resistant Organisms. Radioactive Cesium. James Parkinson. Magnetic Call System....................1323 Finland: Drug Addiction in Finland. .1325 France: Delirium Tremens. Heparin for Cold Abscesses. Oxytetracycline for Rheumatic Fever .........................................1325 Italy: Problems of Oncology. Law of the Heart ........................................................ 1325 Sweden: BCG Vaccination. Appendec tomy at Gynecologic Operations. Medical Jubilee ......................................... 1326 Uruguay: Poliomyelitis ................................. 1326 Correspondence: Medicolegal Office. The Cancer Patient ..............................................................1327 Medical Literature A b stra cts...................... 1328 Book Reviews .........................................................1333 Queries and Minor Notes: Acne and Chronic Hepatitis. Dental Caries. Infant Feeding and Circum cision. Convulsions of Childhood. Buck wheat Poisoning. Monocular Diplo pia. Foods Rich in Arginine. Penicillin. Prevention of Blocking of Indwelling WASHINGTON NEWS Catheter ...............................................................=3335 Poliomyelitis Vaccine Grants. Commis sion for Health Officers. Hill-Burton Program. Public Health Grants. LongTerm Veteran Care. ' Rehabilitation Grants. Service for Interns. Social Security Administration Records. Miscellany..................................................... Adv. Page 13 State Medical Associations. . . Adv. Page 18 Tonics and Sedatives........................Adv. Page 52 The Bright Side.................................... Adv. Page 58 Books Received ................................... Adv. Page 72 Index to Advertisers.......................... Adv. Page 74 Volume 159, No. 13_____ Published Weekly at S35 North Dearborn Street, Chicago 10, Illinois. Subscription, $15. Single Copy, 45 cents P e d i a t r i c O r t h o p e d i c s -- 16 most freaup^t1' ' ~;P,30"aoa I**03 AClipnricasctoicfaNl oSrytmh pAomsieurmicai--n-dtihaegnNoosivsemanbdertrNeautmmebnetr ooff ththeemPoesdt iacotrmic- mon orthopedic disorders in children. Full contents inside. S3 * AA.._, Q', `i f ' ' ^^^ <'J* 0 3 * 1264 Nov. 26, 1955 SCIENTIFIC BASIS FOR THE SURGICAL TREATMENT OF CORONARY ARTERY DISEASE Claude S. Beck, M.D. David S. Leighninagnedr, M.D., Cleveland To understand the scientific basis for the surgical treatment of coronary artery disease it is necessary to analyze information obtained by experiments on dogs. One of us (C. S. B.) and his associates have done about 5,000 operations on the coronary blood vessels in the last 23 years, and these are the basis for this presenta tion. There are several variables inherent in this work, and it is appropriate here to state that these must be properly taken care of, otherwise erroneous conclusions will be made. A report on much of this experimental work has been published in T h e J o u r n a l .1 In these ex periments the reduction in coronary artery inflow was produced by placing ligatures around the coronary ar teries. In the human, arteriosclerosis produces reduction in coronary artery inflow. The net result is reduction in arterial inflow. This is not a study of arteriosclerosis. Even if this disease could be produced experimentally in adequate numbers of dogs the occlusion probably could not be localized nor could the degree of occlusion be con trolled with the precision demanded by the experiment, and as a method of investigation it would be inferior to the ligature. The surgical treatment of coronary artery disease is based upon four considerations. 1. Operation adds 4.7 Cc. of blood per minute (282 cc. per hour) to an area of myocardium made ischemic by complete ligation of the artery that normally feeds this muscle. This quan tity of blood is of little or no significance if it is delivered to myocardium that is fed by a normally patent artery or if the artery is occluded by three-fourths of its di ameter. But if the artery is totally occluded then this quantity of blood is protective. When the circumflex artery is ligated in a normal dog the average amount of blood available to the muscle beyond the ligature is 3.8 cc. per minute. Operation adds 4.7 cc. to this quantity, making an average total of about 8.5 cc. per minute. 2. This quantity of blood accomplishes three favorable results: It reduces mortality following test coronary artery occlusion, it likewise reduces the size of the infarct in these dogs that live following the arterial oc clusion, and it provides time for additional blood to run into this low pressure area of occlusion from adja cent high pressure areas of myocardium. In a few days this ischemic but viable myocardium begins to contract. In 24 dogs the average amount of blood available to the myocardium beyond the ligature was 62 cc. per minute. UniFvreorsmitythHeosWpietastlse.rn Reserve University School of Medicine and the 104RtheaAdnnbuefaolreMteheetinSgectoiofnthoen ASumrgerericya,nGeMneerdaiclalanAdssAobcidaotmioinn,al,Atalatntthice City, June 8, 1955. HeaTlthhisSwerovricke wanasd stuhpepCorlteevdelabnyd gArraenats Hferaomrt SthoecieUtyn. ited States Public cal TWheorbkus,rs20u0s4edSUinCltahier nAuvme.b,erCle1veolpanerda.tion are made by Kapp Surgi Arte1r.y DisBeaescek,,J.CA. .SM., . aAn.d 1L5e6igh1n2in26ger(N, oDv.. 27S).: 19O54p.erations for Coronary 3. Of all the people who die of coronary artery disease about 90% die because the heart becomes electrically unstable. The hearts in these people are capable of continued function under slightly altered circulatory con ditions, and these are the patients who can be helped by surgical operation. The remaining 10% of the patients who die from coronary artery disease have extensive myocardial degeneration, and these patients die in circu latory failure. Little or nothing can be accomplished by surgical operation in these patients (fig. 1). 4. The transfer of this information from the laboratory to the human patient is being made without conflict in the science. ELECTRICALLY STABLE AND UNSTABLE HEARTS An electrically stable heart is a uniformly well oxy goefnoaxtyegdenhetaernts.ioEnmthprhoausgishoiustptlhaecemdyuopcaorndituhme u(nfiigfo.r2mAit)y Electrically Unstable Electrically Unstable Electricallystable Heart Heart Without Infarct Heart With Infarct With InfarctandFailure 90 _ 80 TOrt 60 ^0 50 4* 40 G . 30 zo - I1 10 - - - -- -- - I I -- 1 ________ infFairgc.t, 1e.--ithOerneo-tlhdirodr orfeceanllt, vaicctcimorsdinogf ctooroYnaateryr.4arItnerythisdisgeraosuep,hacvoleumnon v1i,cttimhes hdeiearotsf bcierccaumlaetoreylecfatriliucarlel.y Inuntshtaisbleg.roAupp,prcooxliummantel3y, t1h0e%cuorrfenatlsl itnhceidheenatratlatnod psrtaobgirleitsysivweasocmclauisniotanisnewdefrreomnevoenre sotrcocnlugsioennoutoghantoothfeibrriulinattiel faanidlureinsstuapbeirlivteynedw.erOef pthreesernemt,aiannindg, 5i7n%m, aconlyumonf 2,thbeoseth smpeucsicmleendsa,mathgee dweosutrlducthiaovne obfeenmupsocslesibwleaswenroet itsonogtrefaotr btuhte tehleacttriccoanltipnouteedntifaulsncttihoant dtheesrtreoywedas tnhoe mcouosrcdleinadtaemd agmee, chaanndismco.ntIinnuedthefufnircsttiongrowuaps opfosspibatleienitns this group, provided the heart remained electrically stable. Stability persists when the oxygen tension is reduced provided the reduction is uniform throughout the myo cardium. A uniformly cyanosed heart is also a stable heart, as indicated by observations made in our labora tory on about 60 dogs in which the intratracheal tube was clamped off for periods of six to nine minutes. The heart in these experiments became increasingly cy anosed; it dilated; the beat became weak, and then it stopped in standstill. In none of these experiments did the heart fibriliate. When oxygen was again delivered into the lungs and the heart massaged a few times a strong vigorous beat was restored. Thus the mechanism car dFiiagl . e2l.e--ctrDoocgardhieoagrrt s a milsl udstermatoinngs tfroatuinr g c omndeiatsiounresmoef nmt yoof c aerledciatrlicoaxlygpeonteantitoianl,s .wAith adnidre ct C eaprie- tchyeansoasmede.hTehaerts;e thheeaortnseairseuenliefcotrrmiclayllywestlal bolxeyagsensahtoewd,nabnyd tthhee iostoheelrecitsriucnSif-oTrmselygmaenndt sienveeraeclhy cuonnifdoirtimont.hrBouagnhdouDt. Tarhee eSl-eTctsriecgamlleyntuinsstdaebplreesbseecdaouvseertthhee opxinykgeonr wteenlsl-ioonxyigneneaatcehd mheyaorctairsdinuomt satnrdonegleevnaoteudghovtoerfitbhreillbaltueethoerhceyaarnt.oTsehde mteyrmoca"rcduiurrmen. tTohfesoexydgifefne-rdeinfcfeersenintiaplso"teinstiianltsroadrueceodftetno rinepjularecde h"ceuarrtr.ent of injury," which is obviously incorrect. A uniformly cyanosed heart is not an Yol. 159, No. 13 CORONARY DISEASE--BECK AND LEIGHNINGER 1265 remained coordinated as the heart changed in color from pink to blue and back again to pink. Direct epicardial electrocardiograms taken from the surface of the uni finorfmigluyrpein2kA aannddthCe. uTnhifeorhmealyrtcybaencoomsedesheelaercttraircealslhyouwnn stable and may fibrillate when the oxygen tension is not uniform throughout the myocardium. Thus a cyanosed area surrounded by well-oxygenated myocardium or a well-oxygenated area surrounded by cyanosed myo cardium are conditions that produce electrical instability. These conditions are produced experimentally by liga tion of one or more coronary arteries in a well-oxygen ated heart and by delivery of pink (arterial) blood through a catheter in a coronary artery in a deeply cy anosed heart. The appearance of these two types of trigger and these hearts the are eslehcotwrincailnpfoigteunrteia2lsB from and Dth.e surface of These dif ferences in electrical potential from pink and blue areas measure 5 to 20 mv.2 They are produced at the precise plane of contact between blue and pink and pink and blue muscle. They are produced by differences in oxygen tension, and we use the term oxygen differential to refer to this phenomenon. The term "current of injury" has been commonly used to refer to currents produced by ligation of a coronary artery, but this term is probably not correct. The terms stable and unstable heart are also of recent origin and seem to have a place in cardiac nomenclature. No doubt the amount of current and the voltage pro duced under experimental conditions vary in different dogs. The same current may fibrillate the heart in one dog and fail to do so in another. In different dogs and under different conditions there appears to be a dif ference in what might be referred to as the threshold for fibrillation. The threshold for fibrillation is lowered by hypothermia in the absence of coronary artery oc clusion, and in a series of experiments in which the de scending ramus of the left coronary artery was ligated the heart fibrillated in every experiment, whereas under normal temperatures the incidence of fibrillation was 50% .2 Electrical instability leads to fibrillation and death in a large number of people. The classic example of this occurs in the man who goes out and shovels snow and in a few moments is dead. The exercise improves oxy genation of myocardium everywhere except in an area supplied by a coronary artery that is not normally patent although it may not be completely occluded. In some , instances the arterial disease is slight. Under these con- i \ ditions an oxygen differential is produced that in turn produces sufficient current to fibrillate the heart. Had j this man remained indoors without this vigorous exer- | else the circulation of red blood into the myocardium I, would have been less brisk; the heart under conditions H of rest would have been less pink; and the oxygen dif- t; ferential probably would not have produced sufficient |i current to have fibrillated the heart. To society the loss fe produced by' these currents is incalculable. These cur- j || rents occur in people who could live productively pro- i l l vided small alterations were present in the coronary artery circulation. One-third of all victims of coronary H artery disease have no damage in the myocardium, either ^ fcold or recent,4 and many of the remaining two-thirds have heart muscle that probably could continue to func tion for years were it not for these currents. In about 10% of the victims of coronary artery disease these cur rents were never severe enough to fibrillate the heart; the patient continued to live, and the occlusive disease advanced to the point where extensive damage and fail ure occurred. It appears then that oxygen differentials of a fatal nature can be produced in the absence or in the presence of myocardial destruction. It also appears that myocardial destruction can proceed to the stage of failure without producing currents strong enough to fibrillate the heart. The production of currents and the destruction of muscle are both related to oxygen, but they are different biological processes. The purposes of surgical operation are to reduce these currents and to preserve viability of muscle although the occlusive proc ess may proceed later on even to the point of cardiac failure. SURGICAL OPERATIONS The principles for aiding a crippled coronary circula tion were previously presented in The J ournal.1 Ac cording to our experience the most important aid is provided by the presence of intercoronary arterial com munications, so that a red blood cell entering the de scending ramus or one of its branches can get over to the' circumflex ramus or one of its branches, where it fulfills a more important function. The addition of blood from outside sources is less effective than the distribu tion of blood that is already in the coronary system. We tried to add blood to the heart in many different ways, one of which was to enter it through the coronary sinus system of veins in a retrograde direction. This method provides the greatest amount of protection of all methods that we tested, but retrograde flow tapers off in the dog after six to eight weeks and is replaced by a protective set of intercoronary channels. Whether retrograde flow tapers off in the presence of coronary artery-inflow dis ease in the human patient cannot be stated at this time. Other sources of flow from the outside, such as from parietal pericardium, mediastinal fat, lung, internal mam mary arteries, chest wall, omentum, spleen, and in testine grafted upon the heart, are yet to be measured. Considerable work on this subject has been done, and anatomic channels large enough to carry blood have been demonstrated between graft and coronary arteries, but so far measurements of flow have not been done. No doubt these measurements will be made, because meth ods for .measurement are available and some of these surgical procedures may be found to be effective. For the present we have laid aside the operation that diverts arterial blood into the coronary sinus system of veins because the long-term condition of the circulation in the human heart will not be known until a number of speci mens are examined. This operation is technically dif ficult. It requires two stages. It has a definite mortality 2. Brofman, B. L.; Leighninger, D. S., and Beck, C. S.: Electrical Instability of the Heart: A New Concept in Coronary Artery Disease, to 3b.e Spelumbalinsh, eMd.. W., and Brofman, B. L.: The Effect of Hypothermia on Survival Rates Following Coronary Occlusion in Dogs, Surgery 3 7 1 7074.(MAanyd)ru1s9,55E. . C., and others: Coronary Artery Disease, M. Ann. LDeisigtrhinctingoefr,CDol.umS.,biaand30B:r3o1fm3an(J, uBn.e)L.:19S5y1.mpYoastieuim, Won. CMo.r,oBnaercyk,ACrt.erSia.,l Disease, Am. Rev. Tuberc. 71:904 (June) 1955. 1266 CORONARY DISEASE--BECK AND LEIGHNINGER Noy. 26, 19 and also some side-effects from the arteriovenous fistula produced by the operation. However, as stated above, it produces the greatest amount of benefit, and we might apply it in those patients who still have pain after the number 1 operation has been used. The Number 1 Operation.-- The number 1 operation consists of the following steps. 1. The lining of the parietal pericardium and the surface of the heart are NORMAL BECK NO. 1 OPERATION anFdig.in3.d--ogMsauutpz-oGnrewghgicbhacnkuflmowberme1asoupreemraetniotns iwn asnordmonael . coAnvtreorlagdeogins 6n7umnboerrma1l odpoegrsatiwonas w3a.8s dcco.nepewr ams in8.u5tecca.ndperinm4i1nudteo.gsTihnis wihniccrheastehde btraocckafrlodwiogwraapshipcreseevnidt enoncee yoefarpraoftteerctioopnerawtaiosn.prSetasernti,ndaicnadtessotlihdat ceirleccle indicates it was absent. This operation has been well tested in the expel mental laboratory. The protection of the number1 operation in terms of mortality and size of infarct L been reported.1 In normal dogs the mortality followmi complete ligation of the descending ramus of the lef coronary artery at its origin in one step was 70%. In 3fl* dogs in which the number 1 operation was done ahl sometime thereafter the same artery was ligated, thl mortality was 26.6%. This is a reduction of 4 3 .4 ^ 8 produced by the operation. The hearts in each groutfH that survived test artery ligation were examined and the size of the infarct measured. In the hearts that werell protected by operation the infarct was 60 to 70% fi smaller than in the control group. In some specimens there was no gross infarct, and this was never observed in a specimen of the control group. Backflow.-- The Mautz-Gregg method of backflow yields important information and was used in many ex- periments.8 This method consists of ligation of either-i the circumflex ramus or the descending ramus of the left I common coronary artery. One of these vessels is ligated f| proximally and cut distal to the ligature. The amount of f blood from the cut artery is the backflow. A third ! measurement of protection, which has also been re ported,1consists of the response made by the circulation :: after test artery ligation, provided the animal lived and the heart muscle was not destroyed by the ischemia. Backflow measurements made in an artery that was oc cluded one day were 10.8 cc. per minute; two days, 42.0 cc.; three days, 68.0 cc.; and six days, 20.0 cc.; the average up to four months in 24 dogs was 62.1 cc. per minute. The important consideration here is the fact abraded or roughened by special burs. This produces mechanical trauma, which in turn produces inflamma tion and intercoronary arterial channels. We experi mented with necrotizing chemicals for the removal of epicardium, but no satisfactory chemical agent has been found, and strong chemicals such as carbolic acid should not be used. 2. Application of 0.2 gm. of coarsely ground asbestos is made to the entire surface of the heart. This produces mild inflammation, which persists for a period of months and which in turn produces inter coronary arterial channels. We experimented with many I different inflammatory agents, and asbestos is the most effective agent. 3. The coronary sinus is occluded to a diameter of 3 mm. Ligation of this vein is not beneficial when the arterial circulation in the heart is normal be cause it reduces arterial inflow, but when a major cor onary artery such as the circumflex is occluded then ligation of the sinus affords protection against loss of coordinated mechanism, and it also provides for greater absorption of oxygen from the blood in the occluded vascular bed.56*Ligation also aids in the development of intercoronary arterial channels. 4. Parietal pericardium and mediastinal fat is applied to the surface of the heart. This grafted tissue stimulates the development of inter coronary arterial channels and in some instances prob ably becomes the source of additional blood to the heart. ade5lp. hGiar,egLge,aD&. EFe.:bigCeorr,on1a9r5y0. Circulation in Health and Disease, PhilcEuxipa6et.iro.MnBaiFuotolz.l,lo&Fw.MinRge.d,.Cah3nr6do:n7Gic9r7eOggc(,JculDuns.ei)oEn1.9:3oT7f.hCe oDroynnaarmyicAsrtoefrieCso, llaPtreorca.l SCoirc-. NORMAL EKG TA . (AVR) AFTER LIGATION CIRCUM FLEX ARTERY BACKFLOW - CC. PER MINUTE B. C. D. E. TTO CC. r6 CC. r4 CC. 2 CC. \ * - PRESENT E K G EVIDENCE OF PROTECTION I - ABSENT floFwi.g. 4.--Relationship between electrocardiogram and Mautz-Gregg back- that 4.7 cc. per minute of additional blood provided by operation carried the dog over the crisis of the arterial occlusion and also preserved the viability of myocardium. Under these conditions additional blood ran into the ischemic, low-pressure myocardium from adjacent myo cardium where the pressure was higher, and later on this ischemic but viable myocardium had sufficient blood supply to restore contractility to this area of myocardium. Vol. 159, No. 13 CORONARY DISEASE--BECK AND LEIGHNINGER 1267 Recent measurements obtained by one-of us (D. S. L .) are presented in figure 3. In 67 normal dogs the average his own. The next step is the intravenous administration of 10.5 mg. of tubocurarine chloride. The Rand-Wolfe backflow was 3.8 cc. per minute. After the number 1 operation was done the backflow in 41 dogs was 8.5 cc. mechanical respirator is used and is recommended. Nitrous oxide and oxygen, 5 liters of each, making a flow per minute, or an increase of 4.7 cc. This increase in backflow was found one year after operation, so that of 10 liters per minute, are given. A little ether is given, but usually curare and nitrous oxide maintain the anes the improvement is probably of a permanent nature. The relationship between backflow and electrocardio thesia. The amount of ether used is about 2 to 3 oz. (60 to 90 cc.) per patient. We do not use rebreathing. gram is shown in figure 4. Any quantity of blood added to that which is already present is protective. When the The drugs used are as follows: pentobarbital (Nem butal) sodium, 0.2 mg., given the night before operation; total quantity of backflow is 6 to 10 cc. per minute digitoxin (Crystodigin), 0.1 mg., given just before the electrocardiogram shows S-T segment depression less the patient is moved to the operating room; and desace- than 2 mm. and is indicated by a star. When the total tyllanatoside C (Cedilanid-D), 0.2 mg. given intrave backflow is 2 to 4 cc. per minute it shows greater S-T nously if the heart rate is over 110 beats per minute. segment depression or the heart may fibrillate, and this This is repeated if necessary, or 0.4 mg. may be given is indicated by a solid circle. The various components in one dose. This digitalis preparation for intravenous of the number 1 operation were measured, and these use is an important aid in slowing the heart rate, and its are shown in figure 5. Each component contributes use should not be overlooked. It requires 20 minutes something to the backflow. to become effective. Atropine in doses of 0.2 to 0.4 mg. Thompson 7 advocated the introduction of 4 to 6 gm. of talc into the pericardial BECK N O . 1 COMPONENTS ol BECK N O .l OPERATION cavity for the treatment of coronary artery OPERATION Individual Components Combination! disease, and backflow in such experiments is given in figure 6. The average backflow in 20 dogs was 4.8 cc. per minute. This figure is 1.0 cc. greater than the average normal but is 3.7 cc. less than obtained in the number 1 operation. Vineberg 8 im planted the internal mammary artery into the myocardium of the left ventricle for the treatment of coronary artery disease. This artery is ligated and severed, but an intercostal branch is left open. The artery is placed in a tunnel in the myocardium with the expectation that branches will de velop from it and these branches will con nect with the smaller branches of the coronary arteries. Backflow measure ments were made, and the results are shown in figure 6. The average backflow hoFriizgo.n5ta.--l lMinaeuitnz-dGicraetgegs tbhaeckafvleorwageanndormvaarliobuasckfcloomwp. oBnernoktsenolfinensuminbdeircat1e oapveerraagtieonb.ackSfololiwd in each procedure. Each procedure adds something to backflow. in 20 dogs was 3.9 cc. per minute. This operation did not increase backflow measurements over is given intravenously for nodal rhythm. Procainamide the normal, and the measurements were about the same (Pronestyl) hydrochloride, 100 mg. diluted 10 times in with the mammary artery occluded by clamping or not saline solution, is given intravenously for ventricular occluded. In these experiments there was no increased extrasystoles. Tachycardia and S-T segment changes backflow even from intercoronary arterial channels. in the electrocardiogram are treated by stopping the When the artery was severed the proximal end bled operation for several minutes and oxygenating the lungs freely but the distal end yielded either no blood or less well. The lungs should come up well and then relax than one drop per minute. Vineberg stated that the im with each respiration. If the blood pressure falls, plant should be made into ischemic myocardium for mephentermine (Wyamine) sulfate, 7.5 mg., is given anastomoses to develop, and that was not done in these intravenously and twice this amount is given intramuscu exrperiments. OPERATION ON PATIENTS larly. The patient is placed on his right side with the left The patient is given 0.6 mg. of atropine sulfate and 10 mg. morphine sulfate one-half hour before being side up. If the blood pressure falls below 90 mm. Hg the operation is not started. Time is taken to observe moved to the operating room and in the operating room is given 50 mg. of diphenhydramine (Benadryl) hydro the blood pressure. If the pressure remains below 90 mm. Hg for the next half-hour, the operation is not done chloride intravenously together with 0.4 gm. of thio pental (Pentothal) sodium and 60 mg. of succinylcholine 7. Thompson, S. A., and Plachta, A.: Fourteen Years* Experience chloride. He is given 100% oxygen for three to six min utes, and he is then intubated with a properly fitting Swuitrhg.C2a7rd:i6o4pex(yJainn.)th1e95T4r.eatment of Coronary Artery Disease, J. Thoracic 8. Vineberg, A.; Munro, D. D.; Cohen, H., and Buller, W.: Four cuffed endotracheal tube. Ether and oxygen are then given, and respiration is assisted until he breathes on Yineatrhs'e CTlirneiactaml eEntxpoerfienHcuemwanithCIonrtoenranrayl MAarmtermyarIynsAurfftiecriyencImy pIlnacnltuadtiionng Additional'Experimental Studies, J. Thoracic Surg. 2 9 :1 .(Jan.) 1955. 1268 CORONARY DISEASE--BECK AND LE1GHNINGER J.A.M.A., Nov. 26, 1955 and the patient is not acceptable for operation. By ex perience we learned to regard this as a rule not to be broken. The incision is placed between the sixth and seventh ribs, extending from a point about 8 cm. from the midline in front to a point about 6 cm. from the midline in back " VINEBERG " "THOMPSON" a hemostat, separating the sinus slightly from its bed. A curved needle that contains silk is passed directly into the right auricle parallel to the sinus. This curved needle is then turned 90 degrees so that the point comes out of the auricle just superior to the sinus (fig. 9). The circumflex artery lies close to the passage of the needle, but with care it can always be missed. The ligature is tied around the sinus plus a stilet 3 mm. in diameter. The stilet is removed and partial occlusion of the sinus is accomplished (fig. 10). This ligation is done after the surface of the heart is abraded (fig! 11) and also after 0.2 gm. of coarsely ground asbestos is applied to the surface of the heart (fig. 12). The mediastinal fat is then brought into contact with the heart over as wide an area as possible, and the pericardium is loosely closed (fig. 13). A drainage tube is placed in the left pleural cavity and attached to a water-seal. If a cartilage is broken, it is carefully wired together. The sixth and seventh ribs are sutured with a wire. The soft parts are closed with silk. The patient is given oxygen intranasally or is placed in an oxygen tent for 24 hours and ambulation is started. The patient is discharged in about two weeks. INDICATIONS FOR AND LIMITATIONS OF OPERATION Operation is indicated in the treatment of coronary artery disease. Any patient in whom the diagnosis of this disease is established is a candidate for operation InFoijni.e 6g.--rouMpautthi'e-GVrciin'iefbebragckpfrloowcedmureeasuwraesmednotnse.inAvtweroaggerobuapcskfololwdowgass. 3g.r9oucpc. thpeerTmhoinmuptes;oninpnroocremdaulredowgsasitdoisne3..8Acvce.rapgeer bmaicnkuftloew. Inwatshe4.8othcecr. per minute, which is 1 cc. greater than normal. (fig. 7). The ribs are spread apart by a self-retaining retractor for a distance of 12 to 14 cm. The pericardium is opened by an incision from apex to base about 4 cm. to the right of the left phrenic nerve. Traction sutures are placed in the pericardium and held up by the weight of a hemostat. The lining of the parietal pericardium is abraded everywhere by special burs. Another incision is made parallel to the first incision but to the left of the nerve, and a third incision splits the pericardium at right angles down to the coronary sinus. Traction sutures are applied to the cut edges of the pericardium (fig. 8). Ex ploration of the myocardium and coronary vessels is carried out. The common left coronary artery is lightly palpated by the right index finger. This vessel is nor mally patent, thickened but pulsatile, or it may be cal cified. The descending ramus is palpated, as is also the first part of the circumflex ramus. The branches of these vessels are observed as to pulsation, beading, or streaking. The myocardium is observed for the pres ence of an infarct. The infarct is observed for size, lioscoabtsioenrv,eadn.d paradoxical pulsation. The coronary sinus A point is selected between the middle and posterior veins of the ventricle. The epicardium just below the sinus is nicked with scissors, and a small opening is made and the tissues are gently spread with the point of sixFthig.or7.--sixLtehftasniddeseovfencthhestribiss oapseinneddicbaytedinicnisitohne binetswete.enThtehepefrifitchardaniadl incisions are indicated by the broken lines. provided the disease has not advanced to the point where the risk of operation is too great. Diagnosis will not be discussed. The problem is to determine the stage of the disease when the operation should or should not be . Vol. 159, No. 13 CORONARY DISEASE--BECK AND LE1GHN1NGER 1269 done. Patients with signs of failure, nocturnal dyspnea, and marked enlargement of the heart are almost auto matically excluded. Patients with slight or moderate en largement of the heart without failure are accepted. Operation is delayed in patients with rapidly increasing pain and disability because these symptoms may indi cate progress of the disease and an impending infarct. If decision for or against operation is difficult, it is ad visable to delay decision for several months after which reappraisal is made. Patients with status anginosus have been accepted. We prefer not to accept patients ad dicted to drugs, but in several patients this habit, if present, was broken. Operation is indicated early in the course of the disease rather than late. The experi ence usually has been that the disease is worse at the operating table than anticipated. progressive in patients in the 20's and 30's than those in the 40's, 50's, and 60's. The youngest patient operated upon was 27 years of age and the oldest 71. The operation has limitations that, if properly under stood, will make its beneficial effects more readily ac ceptable. It does not treat coronary arteriosclerosis; it. traFtiingg. 9t.h--ePllaefctingatraiumsutuinre aardouirnedctiothne pcaorraolnlealryansdinucsl;osBe rtoneetdhlee spinenues. Nsuepeedrlieoristothtehne stiunrunse.dTienmapocrlaorcykwtriasectidoinrescutitounres90ardeegirneetshetofaetmteorgeexpjousset sinus. treats alterations in inflow produced by the disease. It therefore does not reduce the disease in the arteries, nor does it stop its progress. It may become more marked after operation. A similar statement may be made about the myocardium. Operation does not re- carFdiigu.m8,.--anPdericcoarrodniuamry ospinenues.d Cfoormmobosnerlveafttiocnoroofnacroyronaratreyryaratnedriesc,ircmuymo cfloerxonraarmyuasneorfv lceaftnnaorttebrye sceaennnootr bpealpsaeteend. but can be palpated. Right After an infarct has occurred, a period of four to six months is given before operation is done. This delay serves several purposes. It affords time for intercoronary channels to develop after the low pressure bed has been established by the occlusion, and clinically it gives the patient time to "level off" so that his condition can be compared before and after operation. Also, electrical instability accompanies occlusion, and an anesthetic plus manipulation of the heart at operation may lead to I ventricular fibrillation. This instability becomes less after 6 the scar has formed and has become electrically inert. II Another reason for delay applies to patients in whom # one occlusion is followed by another. These patients S have progressive arterial disease, and they are not candiS . dates for operation. The disease is more likely to be onFiag. st1i0le.--t P3armtimal. liingatdioianmeotfer,theas coinronAa,ryB,sinaunds. CT,heanldigatthuere stisilettieids removed >after the ligature is tied, as in D. store an infarct to functional myocardium; however, it does reduce the size of the infarct or even prevent the formation of an infarct if another artery becomes oc cluded. It is possible for the symptoms to become worse in a patient who has shown clinical improvement after operation. This is brought about by the progress of the 1270 CORONARY DISEASE--BECK AND LEIGHNINGER T.A.M.A., Nov. 26, 1955 arterial occlusion, so that it is possible for the patient to be in worse condition clinically sometime after opera tion; yet the operation has saved the patient's life. The patient may die of coronary disease sometime after operation, but the experience so far seems to indicate that the operation prolongs life. shoFuigld. n11o.t--bEepiucsaerddifuomr trheims opvuerdpobsey. special burs. Necrotizing chemicals RESULTS OF OPERATION The results of operation can be determined by three measurements, as follows: (1) symptoms before and after operation, using the patient as his own control; (2) ability to work and to exercise, again using the pa tient as his own control; and (3) prolongation of life after operation. The first two items are shown in figure 14. Approximately 90% of the patients have less anginal pain or no anginal pain after operation. Several patients were operated upon who did not have any pain before operation, and these are not counted in these results. Some patients state that the angina is better three days after the operation. This improvement may be mental, but early changes in the circulation, as shown by experi ment, do occur. When such mild therapy as a small quantity of whiskey or a glyceryl trinitrate (nitroglycer ine) pill can reduce angina, it is not inconceivable that a few drops of blood to ischemic muscle could also give relief. As a rule the patient operated upon for coronary artery disease complains less of incisional pain than does the patient operated upon for mitral stenosis, and the in cision in each is almost the same. Some patients do not show improvement for several months after operation. The explanation for this cannot be given. A small percentage of the dogs failed to show increased backflow after operation. About 10% of the patients do not show any improvement after operation, and this aspect of the problem requires further investiga tion. Some of our patients are classified as salvage. These patients have severe arterial disease in the com mon left coronary artery or in each of the major branches of this artery. They also have extensive infarcts, some- times with aneurysm of the myocardium. In these pa tients not only is the operative risk high but it is often difficult for us to understand how they can be helped by the operation, and yet some of the best clinical results are obtained in this salvage group. The best results are almost unbelievably good. In some patients pain and disability are completely re lieved. Such almost miraculous results are occasionally seen in patients without operation, and the explanation is the same as in the operated patients. Each patient de velops a good set of intercoronary channels, one without operation, the other after operation, and the occlusive disease does not get worse. The end-result is the same. Indeed, operation accomplishes what nature can do but fails to do in a sufficiently large number of patients. In about 90% of the patients the ability to work is im proved. Many of the patients return to jobs that they could not do before operation. It is gratifying to see this type of result; however, the patient is advised before operation that there is a good probability he will be better after operation but that he will not be cured of his disease. It is difficult to make definite statements concerning the prolongation of life after operation. The arterioscle rotic process in the coronary arteries follows a variable and unpredictable course. These variable factors were eliminated in the experimental work because by use of the ligature the arterial occlusion was a known factor. In the dog it would be undesirable to reduce coronary artery inflow by the arteriosclerotic process even if it groFuign.d 1a2.s--beSsptorsi)nkolivnegr othf eanenitnirfleamsumrafatocrey oafgehnetar(t0..2 to 0.3 gm. coarsely were possible to do so. This study of coronary artery oc clusion would not exist if it were not for the fact that controlled occlusion by the ligature was used. It is a fact that a surgical operation can be done on a normal dog heart, and sometime thereafter a coronary artery can be ligated ompletely and in one step, and the dog has a Vol. 159, No. 13 CORONARY DISEASE--BECK AND LEIGHNINGER 1271 better chance to continue to live than it would had the operation not been done. It is desirable to present information on the patients concerning arterial occlusion' and mortality subsequent to operation, but it is scarcely possible to do this with the data available at the present time. Our medical cardiologist, Dr. Bernard Brofman, is working on this subject, and our belief is that arterial occlusion occurs after operation and the clinical evidence is often not adequate to make a diagnosis. This is favorable for the operation. It is likewise our belief that the operation pro longs life, but to prove this statement on a statistical basis requires two identical groups of cases. Lindgren reported mortality in a group of 88 patients who were acceptable candidates for sympathectomy for angina pectoris, but the operation was not done in these patients because of nonmedical reasons.9The mortality was 17% this subject. It is desirable to measure this aspect of the work by operating on alternate patients and determin ing mortality in both groups, but this is for the future. SUMMARY AND CONCLUSIONS Uniform distribution of oxygen to myocardium pro duces an electrically stable heart; lack of this uniformity produces an unstable heart. Differences in electrical PAIN: NO PAIN LESS PAIN - 45 * 45 * TOTAL - 90 * ABILITY TO WORK: BETTER ABLE TO WORK, NO LIMITATIONS BETTER ABLE TO WORK, SOME LIMITATIONS - 35 % 1 I TOTAL - 90 % 55 S J 9 out of 10 Back to Work and Relatively Free of Pain. moFnitgh.s 1o4.r--mColirneicaplosrteospuelrtsatiivnely1.03 patients who could be evaluated six potentials of the heart are produced by "oxygen differ entials." The term "current of injury" is probably not correct. A uniformly cyanosed heart is not an injured or an unstable heart. With the number 1 operation for coronary artery disease, operative mortality has been re duced to 6.6%. The more important component of this so-called operative mortality is the disease rather than the operation. Operation relieves symptoms in 9 out of 10 patients. So far the trend of experience seems to indi cate that operation prolongs life. Operation adds 282 cc. of blood per hour to ischemic myocardium, and this blood is present at the crisis of arterial occlusion. This is com parable to a transfusion of arterial blood into ischemic muscle. There is no experimental evidence to indicate that medical therapy adds or subtracts a single drop of JANUARY 1, 1M 4 TO MAY 6, 19S5. THORACOTOMY ALONE OPERATIVE AND EARLY POSTOPERATIVE - TOTAL PATIENTS - 75 2 PATIENTS - 2.4 * 3 PATIENTS - 4.0 * TOTAL - 6.6 % FROM DISCHARGE UP TO 15 MONTHS . I PATIENT - J.3 % theFigh.ea1r3t.--asPemricuacrhdiuams ppoasrstiiballely. Hdoerseed.it Misedbiarsotuingahlt fbaetniesatuhsedtheto bcroidvgere mofospteirnicsatarndciuems itciosntaatitnaicnhgedthteo tpheericraigrhdtiacbooprhdrerenoicf tahritserbyridangde ovfeitnis.suIen. the first year and 13% the second year, for a total of 30% for two years. These figures may be compared to our experiences, but the two groups probably are not strictly comparable. The operative and postoperative mortality with the number 1 operation in 75 patients was 6.6% . This mortality rate is lower than our previous figures. In the last 49 patients operated upon at Mount Sinai Hospital, Cleveland, the mortality was 2, or about 4%. The mortality in 136 patients occurring from the time of discharge from the hospital up to one year was 6.6% and in 83 patients from one year to two years was 4.8% . If these figures are added together the total operative and two year postoperative mortality is 11.4%, which is lower than Lindgren's figures without operation. We expect life to be prolonged by operation, and this is the most important purpose of our extensive studies on LATE MORTALITY, SUBSEQUENT TO DISCHARGE, ALL CASES, 1935 TO JUNE, 1954,53. 136 PATIENTS . FROM DISCHARGE UP TO ONE YEAR 83 PATIENTS - FROMONE YEARUPTOTWO YEARS- OEATHS 4.6 % T O T A L. 11.4 * MORTALITY IN PATIENTS TREATED SURGICALLY. OPERATIVE . 6.6 % DURING FIRST YEAR . 6.6 * DURING SECOND YEAR - 4.8 % TOTAL - 18.0 % MORTALITY IN 8B COMPARABLE PATIENTS TREATED MEDICALLY, t lindgren > DURING FIRST YEAR - 15 DEATHS- 17 * DURING SECOND YEAR - 11 DEATHS 13 % ________ _____, -T--O---T---A---L-------3---0-- --% Fig. 15.--Mortality in several groups of patients. blood to ischemic areas of myocardium. In view of this lbime ittoaltdionthtehree piastiaenmt woritehecfofreoctniavreytarertaetrmyednits.eaOsepesrhaotuioldn should be done early in the course of the disease before irreparable damage occurs in the myocardium. 2065 Adelbert Rd. (6) (Dr. Beck). enc9e. to NeLuirnodsgurregni,caIl.:TArenagtimnaenPt,ecAtcotrais:mAed.CslcinaincdailnaSvtu. d(ysuwpipth. 24S3p)ec1ia3l8Rsefer 1, 1950.