Document pmN2avd7JmbgBYGZkGOR1d6nj

St. Louis, Missouri y D. H. Bechtold cc: R. W. Bucknell J-,A. Cannon -*J. R. Darby A. G. Eades M. W. Farrar E. H. Fording R. E. Larrikin A. W. Morgan J. H. Orem W. E. Schalk N. W. Touchette df: Baxter-Travenol 1180 B3NB 1760 1760 B3NJ R2E B3NJ_ B3NC 1760 B3ND B3NJ 1760 COMMERCIAL DEVELOPMENT CALL REPORT NO. 72-70 BAXTER TRAVENOL LABORATORIES MORTON GROVE, ILLINOIS Date of Call: October 10, 1972 For Travenol Labst Mr. H. Gajewski, Technical Director For Monsanto: C. W. Cook P. R. Graham Objective: To review Santicizer 334F evaluations Summary; Baxter Travenol is entering Phase II of their search for a re placement for DOP in blood bags. Santicizer 334F is still the leading candidate. In addition to the H2O extraction "problem" with S-334F, Baxter has found S-334F systems to blush after steam autoclave sterilization. DOP also blushes but the clarity returns in a shorter time period than S-334F. They will begin evaluation of S-334F Special immediately. Based on the improved H2O resistance of S-334FS, a definite improvement in blushing is anticipated. The pressure appears to be on Baxter to qualify a replacement candidate. Details: . No processing or performance (other than H2O resistance) stands in the way of S-334F use in blood bags. The Union-Camp polymeric, ` DSW588313 STLCOPCB4093649 COMMERCIAL DEVELOPMENT CALL REPORT NO. 72-70 BAXTER TRAVENOL LABORATORIES Page 2 being evaluated side by side with our product, has exhibited a narrower GPC range. However, uniformity from batch to batch has varied. Baxter is still very much opposed to the use of BHT and other antioxidants in the blood bag. , Their test for blushing is to autoclave film for 1 hour at 235F. and observe the time required for the film to clarify. It takes four to six hours for S-334F to become clear as opposed to two to three hours for DOP. P. R. Graham DSW 588314 STLCOPCB4093650