Document pmDJ9jYDwZEDeD8NN0mzBXqQD

ILea! U. B. HA PF NCR , PRESIDENT wl. M. BOWLBV, VICE PRESIDENT K. C. BROWNELL, VICE PRESIDENT J . A . M A R T I N O , VICE PRESIDENT ROBERT UINDLEY ZIEGFELO, SECRETARY- TREASURER to^Ialiai 4-20 LEXINGTON AVENUE NEW YORK17.N.Y. M A N FRED BOWDI TCH D I RECT O R O F H EA L T H A N D SA FET Y June 1, 1955 Robert A . K ehoe, M. D ., D i rector K etter i ng L aboratory of A ppl i ed Phy si ol ogy U ni v ersi ty of C i nci nnati Col l ege of M edicine Eden A venue C i n ci n n ati 19, Ohio D ear Bob: I th i n k you may read w i th some i n t e r e st th e two encl osed para graphs from D r. Chi sol m, the f i r s t o f which r ef er s t o the su b j ect of my l e t t e r t o you o f May 2l |th , on w hi ch I hope v ery much to have y our view s when you can get around to respondi ng to ray m i scel l aneous r ecen t p ester i n g s. As t o th e second, w hi ch tak es i n to consi der ati on one of th e poi nts I had i n mind i n my as y et unansw ered l e t t e r t o Randy B y ers, I w i l l comment f o r th e moment onl y t h at I f i n d q u i t e f asc i n at i n g th e v ar i et y of r ej o i n d er s el i c i t ed f rom d i f f er en t m edi cal sources by th e same query . W hile a l l o f t h i s i s h el p f u l , and i n t h at r esp ect a l l to the good, i t serv es once more t o p o i n t up th e need of some such di agnosti c stan d ar d i zer as t h at m edi cal f i l m I have proposed. L et us hope t h at th e l ab o r ato r y sur vey on which th e C i nci nnati USFHS boys ar e embarking w i l l accompl i sh some thi ng t o t h at end. Si ncerel y , MB:MM KE 0014385 Ex cerpts from l e t t e r dated May 27, I 9i & from J . J. Chisol m J r . , M. D. t o M anf red B ow di tch. W ith regard to t h e anonymous r eq u est f o r f i n an c i al sup port# I th i n k t h e f ol l ow i ng comments ar e j u st i f i e d . The problem th e ap p l i can t w i shes to undertak e shoul d be c l assi f i ed as one i n b asi c m etabol i c research i n t o the bi ochem i cal mechanism of l ead t o x i c i t y . I t i s th e ty pe o f problem w hich may become v ery com p l i c at ed and th er ef o r e one i n which the i n v est i g at o r cannot guarantee t h at he w i l l be abl e to f i n i sh th e work i n any speci f i c ti m e l i m i t . I n f ac t one coul d esti m ate t h at he mi ght r e qui re at l east two to th r ee y ears to produce any thi ng, p ar ti cu l a r l y i f he i s st ar t i n g from sc r at c h . The prospect t h at the f i n d i n g s would i m m edi atel y add a u sef u l th er ap eu ti c agent to th e p r esen t armamentarium seem sl i g h t . I n sh o r t i t i s not the ty pe o f problem w hich i s l i k el y to y i el d a y es or no answ er from a f ew ex peri m ents. 'Whether th e LIA w i shes to undertak e th e sup p o r t which 'mould have to be a conti nui ng one# of b asi c r esear ch i s t h e questi on, I b el i ev e, you must f i r s t answ er. I am af r ai d n ei t h er D r. H arri son or I ar e abl e t o add very'much t o the case of th e Chi nese i n f an t on th e b asi s o f the data suppl i ed. There i s no comment, f o r exampl e, about x -ray s of t h e l ong bones. I f broad l ead l i n es ar e p r esen t, they coul d sup p o r t th e i dea of l ong - and perhaps p r en at al - absorpti on of l ead by th e i n f an t . I f p r esen t, a f u r t h er search f o r a common source i n mother and c h i l d i s w arranted. I f on th e o th er hand l ead l i n es ar e absent o f f a i n t , t h i s w ould i n d i c ate exposure of b r i ef d u r ati o n . T hi s m i ght bo ex pl ai ned i f t h e i n f an t had swallow ed a l eaded f o r ei g n body which remai ned i n th e i n t est i n e. We had such a case i n an i n f an t who sw allow ed t h e l ead w ei ght from a t o y d o l l . The w ei ght was s t i l l i n t h e stomach th r ee months l a t e r when th e i n f an t was h o sp i t al i z ed . F u r th er than t h i s on the b asi s of t h e i nf orm ati on suppl i ed I f ear we have no suggesti on. ^g' 0014896