Document pm5NoaJLzGX3OY5dG15pX053d

Atsombiy DO! No. 94* CHAPTER 1041 Am act (a amend Sections 4900 and S406 o to add Section S408J ta and to add Chapter 11 (commencing with Section 4 ill) to Put 1 nl Diction dL the Labor Code, relating to workers' MtipaniaUon, ami making an appropriation therefor. tAoccwW W Cwmw Svatembs* tt ttaa flW vCS Srsmsry *4 Saw faocamker a Iteai LICULATIV* COUMtLf DICtST Alt 940. Agnoi. Workers' compemat lore asbestos workers Eluting law provides chat liability for workers' compensation shall esiat against an employer for any Injury or death sustained by his employees arising out of and in the course of the employment. Tina bill would provide that where an asbestos worker, as defined, is in-tired u a result of asbestosu. as defined. and makes a dalm Car workers' compensation, if the responsible employer oanaot be located or fails to provide workers' compensation within SO days, the worker auy seek the payment of workers' compensation temporary disability and medical benefita from the Asbeitoe Workers' Aeeoaat Existing Law provides that' no proceedings See the collection of workers' compamatloo death benefita may be commenced more than one year after the date of death. or more thaa 140 weeks from the date of Injury. Dim bill weald provide that la eases where the deeth ofaa asbestos worker la frees aabeataala, no proceedings far such benef*a may be*- ' commenced store thaa one you frosa ute date of doath This fall would ueeM the Aibaatoa Wbrkars' Aetna* la the - j, Ururwurwd Eatplayers Fuad,bi the State Treasary, be he aenWwsmujv appropriated Sr the puryeiet ef this bH sad which would pe admialPased hy the Dtreeter ef ladustrial Reiatieea ' Kv/f Thlehtf wmaad ndd refated pewvialaas relatiag te nslmlwmmiat of the Adwstos'Worhen' Aooount by employees deteneleed to be liable far ssfessteels lafury, sad srouw allow the Aabestoa 'Markers' Aeeoaat a tnt lien acsiait workers' cnmpeesatfcw benefits far afl benefits prevlded. and recoverable coats. - - -r ..-u-s. This bin would require the Administrative Director of the DMste* of Industrial Accidents to appoint workers' compensation referees and lupport staff who would give priority to processing the efaime of ashctloe workers, and la appoint at lea# tew infocaiatioa end assistance officers who would give prionty to asdstinp asbestos workers treking benefits Tha tall would provtde that the provisions relating to the peyevees of benefits from the Asbestos Workers' Account shell be iaopsrrsltve as of December 3L 1963, unless a later enacted statute deletes or ' BUP 0933936 DU 036491 ihmmaasbdiuiia -6 w V,.i TWtt ""*"* ""* ' * * extrnds such dale. The authority of the Asbestos Workers' Account to rrcOM'r benefits and costs paid to ubeitos worken prior to such dutr uruld continue until such benefits and coats are recovered. This )i! would incorporate additional changes In Section $406 of the 1 j bor Code proposed by SB 375, to be oporstive on the operative date of this bill only if 58 375 and this bill txe both chaptered and become effective on or before January i, 1981, sad this bill la chaptered lost. Under existing law. Sections 2531 end 2234 of the Revenue and Taxation Coda require the itate to reimburse local agendas and school districts for certain costs mandated by the state. Other provisions require the Department of Finance to review rtatutee disclaiming these costs snd provide, In certain cases, for making claims to the State Board of Control far reimbursement. The statutory provisions requiring reimbursement will be supplemented by a constitutional requirement of reimbursement effective far statutes enacted on or after July L 1860. Tins bill provides that no appropriation la made by thla act pursuant to the constitutional mandat# or Section 2231 or tZH but reengnues that local agencies and school districts may pursue their other available remedies to seek reimbursement far these coats. This bill would appropriate 12.6X3,000 from the contingency reserve for economic uncertainties in the General Fuad to the Asbestos Worken* Account in the Uninsured Employers Fund far the purposes of this btU Appropriation: yea. The people at tha State of California do enact as fofibww SECTION L Cliapter It (commencing with Section 4401) is added to Port l of Division 4 at the Labor Coda, to read: CitAprca IL Ainoros Woaxaaa* Accaewr Article 1. General Provisions ` 4401. It is tbs declared policy of the state that qualified injured workers with ashtstmts which arises out of and occurs ia the course of employment shall receive workers* campamaUoa temporary disability and medical benefits promptly and mst be ash(acted te delays at litigation to determine the responsible employer. 1402 (a) "Asbestoau" moans any peilioiofy, wiirthcr or net cotnidiird with imccxistlng [jothningy, which results in dlseuUHy ur need fie medical treatment from inhaialloo of asbc*i fibers. (b) "Asbestoa worker" means any person when occupation subjected him at her to an exposure to asbestos fibers 4m The Asbestos Workers* Account is Itereby created in the Ummurtd Kmidoyors I**mid in tlx* State Treasury, snd sJiofi be 1% 0U7 0933937 DU 036492 -- 3 CX 104! iilininiitered by the Director of Industrial Helaiions. The money in I bo Ailicsio* Workers' Account it hereby continuously appropriated fur tlie purposes of this chapter, and to pay the txpansas of tho director in administering this* provisions. UM. Insofar as not Inconsistent with the provisions of this dupicr, til uf tho provisions of this division shall pertain to sslnetos Murker? and their dependants lor purposes of fumtsbuif worker's competnation temporary disability tnd medical benefits I bareta -UUS Where the condition* of ocmpensatioe exist under this division the right to recover workers' compensation temporary disability and medical benefits pursuant to the provisions of this chapter is mmnoraru remedy (or injury to on atiwam. -- against the Asbestos Workers Account, and such asbestos worker or his or her dependents shall make all reasonable effort to establish the Identity of the employer responsible hr securing the payment of compensation. 4406. (a) Payments as advances on workers' compensation ] temporary disability and medical benefits shall be furnished as 2 asbestos worker for injury raaulting in ssbestosia subject te the C provisions of this division. If all of the following conditions occur; J (1) The asbestos worker demonstrates to the account tint at the^ time of expense, the asbestaa worker was performing services and was acting within the scope of his or her duties in aa occupation that subjected the asbestos worker to the espesuro to asbestos. (t) The asbestos worker demonstrates ta the account that he or the is suffering from oshestoaia (3) The asbestos worker demonstrates to the'seeeunt that he or she developed asbestests from the employment (4) The asbestos worker Is entitled ta oampensaiioa for aibastosis os otherwise provided far ta this division. (b) The findings of the aocouat with regard to the oondiilans In. . subdivision tel obeli net be evidence la say other proceeding (c) The account shal require the asbestos worker eo submit te aa tadepsadeert medlnl eramlnarinsh 1, I V' ' . 1 Artiaie t leswfits. tl 7 Wfcea the aooouat datersnfarr that the antehrtaea la 1 seed hern occurred, payments ae arhneese an workers' ' sesene i'iHm temporary (Usability sad medknl besmte shal be prmfdjd In aoccrdaxee wtth the chapear, aotwlthetandhtg the right ofthe sdiestes worker te secure compeasedoe stflthpPrteprnrtdod.. for In this dtrhdan. ' 440ft Prior te seeking coraptaaatioe boeefits under this chapter, the asbestos worker shall first make claim on the employer er ks wurkart' cempensallaa Insurance ' carrier far payment of compestsation under this division. If the aabedat nerfcer is enable te loote the rospenrible employer or insurance carrier, or if the DUP 0933938 I>U 036493 W. I.ft." HHl employer or Insurance carrier fails to pay or drme* liability hr the compensation required by this division to the person entitled thereto. w^liiu a purtod of 30ilnys after tlic assertion of such a eiaira, Inc vla'rtm worker nu wok payment of workers' conijjciuaiK'fl temporary disability and medical benefits required by this division from the Asbestos Workers' Account iiOa The Director of Industrial Relations, or his representative, shall assign investigative snd ciatms acijuitment services respecting matters concerning 'Asbestae Workers' Account easts. Such assign ments may be made within the department including the Division of industrial Accidents and sscluding the State Compensation Insurance Fund. 44M.S The sdmuustrative director shall appoint icferees and support staff who shell give priority to the processing of the dainu of eslsestos workers 4110. The administrative director shall appoint it least two Information and assistance ofTic*r< who shall give priority to saisting asbestos workers pursuant to the provisions of this chapter. The information and assistance officer shell assist to the fulled latent possible any asbestos worker seeking benefits under this chapter. Ia oadstlng ilia asbestos worker, the Information and assistance officer shill conduct necessary investigation and procure those records, reports, end information which ire .necessary to the early Idrnufkuiion of responsible employers tnd insurance cstriers, and te facilitate in the espedttlng of payments of benefits that may be due under this division. 4411. (a) Wlicn a claim is made against the Asbestos Workers' Aeonml. ilie account sliall secure appropriate information, adjust the claim, and fay benefits provided by this chapter in accordance with me provisions of this division. | f (hi Tim aslmtoa workor slull |jrior to the fir* payment of v benefits Iry llic As!rates Workers' Acctmnt. flic un sppUeutloo before the Workers' GsoipcnsaUon A|ipoals Board to detomisie the rcsponsilite employer for payment of compensation under tbli division. !c) In every ease Isefore the Workers' Compensation Appeals Board in which a claim of injury from oapaiuro to ssbestos is sllegod, die appeals board shell jaia the Asbestae workers' Account is party to the proceeding and serve the food with copies of all deaf* am tod orders, ieefodhig finding* sad swords, sad order tp sdT&* crtablkhinf the rwpowtUt wiptow m\ Insurance canter k agracd upon be^woon tbo partfefc or k taaiod bf iho Wockan' Compenaatioa Appesk ftconl, and (jecorwM (Wat Uw Asbestos Workers' Aocount shall terminate payment tf compensation benefit*, notify s3 interested parties accordtngty, and seek eeileethai at provided for under this chapter. Reeoorssiljility for payment of afi future compensation benefits shell be in i *r ia* DOP 0933939 DU 036494 with inch agreement, order, or decision. () The account shall terminate the payment ad benefits to any employee who fails to cooperate Fully In determining the rtapoiuibie employer or Ismiraneu carrier. (b The Asbestos Workan' Account may, at any time, eommenen or join in proceedings before the Worker*' Contpensalion Appeals Board by Filing an application on its own behalf In any in which the Asbestos Workan' Account has been joined u i party or has (lied an application on its owe behait the Asbestos Workers' Account shall have all o( the rights and privilege! of t party applicant Article 3. Collections 4411 The Asbestos Workers' Account ihall take all reasonable end appropriate action to Insure that recovery Is nude by the account (or all moneys paid is compensation benefit! and u costa In the event that the responsible employer Is uninsured, tbs account shall not be entitled to reimbursement Frossi the Uninsured Employers Fund. 4411 No limitation ; time provided by this division shall ran against the Asbestos Workers' Account to Initiate proceedlop before the Workers' Compensation Appeals Board when the account has made any payment of moneys. Incurred any oostifor services, or encutnlirrrd any liability of the account 4414. Immedluleiy following the receipt of knowlodge of tnitielina of proceeding* before the Workers' Compensation Appeals Board, or tny other jurisdiction providing benefits for the same injury, the Asbestos Workers' Account shall file Ilea and may Invoke such otlicr remedies as ire available to recover moneys expended for compensation benefits. 4414. In sny hearing or proceeding, the Director of Industrial IWIaikjnt may uso attorneys from within the department, or the Attorney CcrieraL to represent tla director and the itate. 4416. Oaee an agreement as to the responsible employer is reached, or s decision is laued by the Workers' Compensation Appeals Board sad becomes Anal, the Asbestos Workers Account shell notify the reepnmihle employee ee Insurance carrier of the . amount of peymeut ainsarary toatisfy the Beam m Pull payment fc eftla ttsn ihal bo made by the reenraatfii employer or Insurance ft carrier within M days of the tame af suck mUmUm. Th# account w nay grant a raaoonsbVs extradon of Um far payment ef the Ion beyond 40 days Tills payment shall be far el moneys expended tie I1 DU? 0933940 DU 036495 iiiiarffiJSEgrte:jsaiiai.: a. io-ii - agfcrment of decision through the date 0/ payment. TU' lu-n of tlie Asbestos Workers' Account slutll bo allowed 11 a first lien against compensation. and diill liave priority over all other liens. The lien of the Atbettaa Worker*' Account may not be reduced by the Workers' Compenutton Appeals Board or by the parties unless usprvsi writlun consent to the (imposed reduction of the lien Is given by (lie Asbestos Ubrkcrt' Account and la filed fa the record of proceedings before the Workers' Compensation Appuals Hoard. 1117 Nothing la this chapter shall be construed to preclude the filing by an aseestoa worker of a claim or suit far damages or indemnity against any parson other than bis or hsr employee. The Asbestos Workers' Account shell be entitled to raonvac from, tad thall have a first lien againat, any amount which la recoverable by the (niiirrd employee pursuant to dvd judgment or settlement In relation to a claim for damagse or Indemnity far the (fleet 0f >1povure to asbestos, tor sQ oompensation benefits paid to the Injured employee by the Asbestos Workers' Aoeount which have not previously been recovered from the responsible employer or employers by the Asbestos Workers' Account. fieoovsry by the Aal'otus Workers' Account pursuant te the provisions af tide section shall not have the effect ai extinguishing or diminishing the ttabdky of the responsible employer or employers te the Infused employee tor > umpensation payable under the provisions of Usd division. -till The provisions of this chapter providing far the payment of workers' compensation temporary dhahitlty and medical benefill from the Asbestos Workers' Account thall be operative only until Do.umber 3U ltea. and ae of such date all payments from the fund shall be terminated, unless a laiar anactcd statute which is chaptered'*' betute December SU lteSL deletes er extends sack date. However. If no inch statute laenacted prierte Deoeaber *1, lMk the author*/ ef the Aabaatet 'AfarhCia* Apeouat under thl* chapter te reoever the . benefits sad costs paid M mbestos worker* prior te met data ahel ' % ccnrinuc until suabeaaflb and cotes has* been rccevircrl, Js SEC & Saetkn 4m cl the Leher Cede h smanded te reed .* dot The appeals boxrd may detonate* and alow as liana (a) A mournshiis attorneys tee tor legal aarvteea permatag 10 any dates far eompenmtfan either before the agMtb board er betere any at the appellate courts, and the reason*bla dhbuneraestl In DO 0933941 DU 036496 employe* or of his or her dependent!, tubeequent to tli* Injury. _ id) The reasonable burial eipcnias of tha decerned employee, not to exceed the (mount provided lor by Section 470L la) Th* reasonable living expenses of th* spouse or miner children of th* injured employe*, or both, lubeequent to th* date of th* Injury, whr* iuch employe* hot dexerted or !i negleoting hit or her fimily. Such expense* ihaJi be allowed'In rack proporttoo as tire appeals beard deem! proper, under application of toe ipoua* or guardian of the minor children. (0 Th* (mount of unemployment cocnpeDiedo* dixability benefit! which have been paid under or punueet to the Unemployment Insurance Code in thoie can* where, pending ( determination under Divides 4 (commencing with Section 3100) of thucode, th*r* was uncertainty whethersucnaaneflts wer*payable under the Unemployment Inturanc* Cod* or payable bereunden provided, however, that any lien under thia aubdiviaiaa (hail be allowed and paid ta provided in Sectioa 4904 (g) Th* amount of unemployment compern*floe benefits and extended duration benefits paid to the injured employee for th* urn* day or day* Cor which ho or the reootvee, or i* entitled ta receive, temporary total disability indemnity payments under this division; provided howaver, that any lien under this subdivision ihaii be allowed and paid as provided in Sectioa (904 (h) The amount of eempensdien, including expanaaa of medical treatment, and recoverable ooet* which have been paid by th* Asbestos 'Markers' Account pursuant to the prevision* of Chapter a (commercing with Section 4401) of Part L SEC & Section 5409 of lb* Leber Cbdo is amended to reach J404 Except a* provided in Sectioa S40U, the period within which may bo commenced proceodiop for the oolfactioo of the benefit! provided by Art id* 4 (oommaidng with Sectioa 4700) of Cheneer 1 at Pert 1 Is on* year freak (a) The dot* of death whet* death tocun wftfcia eaeyear from (hi 1>*Si** at tost fanriehing at aay beaeffe* under Chapter t , . (cnotowring w*h Section 4BW) of Pacts, whet* death eaerewemte t than *n* yaw from the date of Warn *r ' #* T '{'.tv''* ' () H* data f d*tah whar* *dh ooono aawo the* eoa m f ttot lh* data of infury ted uumpeiwHaa bmirth hast beaa > : htemdsnroeeedleepietay he openmeeird more thaa ne year sher the dtaawf death. nor mare then 1*0 weeks (torn th* date *f infery. SHti 1A ScrikM AWO of llw I olaer'Oifa tffeaaffcknt (dreed 'SriEr M4 Except provided U) Smtiua SKB& th# prrfcei within which may be commenced proceeding* far th# eaUectiaa of the benefit* provided by Article 4 (commend*g with Serbtoo 4TC0) of Chantrf t if Pari S it ir yrOr frank ,, (m) The date of death whetv drtik omn within ar yrar fret# *1 u DU? 3933942 DU 036497 Ch. !04l --8-- ilatr of injurv: or tbi TV bait of lilt furnishing of tny boneflti under Chapter t (commencing with Section 45501 of Pirt 1 where death oecun more than otto year from the date of injury; or (c) TV date of death, where death occurs mere than one year after the date of injury end compensation benefits have been furnished; or id) The service of a notice of rejection of a claim, u provided In Section 34U1 S'n such proceedings may be commenced more than one year after tV date of death, nor more than 240 weela from the date of Injury. SEC 4. Section 5400.5 u added to the Labor Coda, to read: 5u045 in the cose of the death of an ubestoa worker from asbestotis, the period within which may be commenced proceedings fur the collection of tlio benefits provided by Article 4 (commencing with Section 47M) of Chapter t of Part t is oae year from the date of death SEC 5 It is th# infant a/ the Legislature, if this bill and Senate UlU UTS ire both chaptered and boeoma affective on or before January' 1,1981. both btlls amend Section 540* of the Labor Code, and I his bill is chaptered after Senate Dill 373 that Section 5400 of the Labor Code, aa amended by Section 33 of Senate 801373, be further amended nn the affective date of thia act in the form sat forth la Section 55 of tbb act to incorporate the changes 1st Section 340# proposed by this bill Therefore, if this bill and Senate EUQ STS ate 1tot It chaptered and become effective oa or before January 1, 1941. and Senate Hill 373 Is chaptered before this bill and imtods Section 5404 Section 33 of thia act shall beeoote operative o ibo affective date of tills act and Section 3 of this ad shell net beooma operative. SKI I 33 It ts thu latent of the Legislature that funding for administrative costa associated with Impiwmeotadoo of this set sitail come from redirection of the slat# funds appropriated for the base budget of dm Departmerit of Industrial Bslarlnr# In the 19*5-41 to . 194+-85 fimi yean SZCfc NotwithstanrllngSectlai M1 orMStef tWHeveeue and Tscation Cad# tad Section I of Artlcfc XIU B of the CklifanJ# CanatlNtton, aa appropriation is mad# by th* act pursuant to thaae suction# It k recognised, however, that a local agency or school district may pursue any remadie* to obtain refabunainesrt available _ ta I trader Chapter 3 (ootnmendng with Section BOD of Part 4 of " Dtvisien 1 of tkat enda SKI T. Tlie sum of two million sis hundred twenty-five thousand dollars 111833001# is hereby sjipraprtatod (rote the oaotingtncy reserve (nr economic unoertaintiaa la th# Ceneral fund ta the Adapt!oa Waken' Account in tlae Utaimured Craplnyen Fund for the jaurpoan of this act DUF 0933943 DU 036498 .ijaia ia-niteii rati". -t liO. DU 036499 -t hecr.ar.naa of ribrcgenesn Serbara j. !;t Introduction to Fibrosis A. Classical definition ii aorpnolojicai ]. Incraast La connective tissue fibers as son with light microscope 8. Other considerations include changes in: 1. Aaounee 2. Types - collagen, elaetia, microfibrils, jlycoeasunoglyeana, etc. 3. Subsets of thase types, .(, different farms of colli|to, types I to 7 4. Locations C. flbretlc rsspooss to many different insults 1. Chronic dust exposura, pneumocoaioses e. Silica b. Asbestos c. Coal, ate. 2. Acuta injuries cat at later times develop into fibroeis a. Drugs - antineoplaatica, bleomycin, cyclopboaphami.de b. Paraquat c. Hyperoxit D. Examples of different forms of fibrosis 1, Asbestosis - diffuse thickening of incersticitiua, cellular influx vithia elreoli; presence of asbestos bodies 2. Silicosis - nodules, discrete. Very acellular at center Silicotic nodules by polar microscope - birefringence, brl|ht spots. Crystalline silica in sad around lesions. t. What is nature of conaaetive tissue? 1. Chemical constituents: a. Co Hagan - limit expansion of lung. Major component of connective tissue. Regulation of collagen synthesis important ia fibrosis. 091^45 pUP DU 036500 b. Mierofrils ~s y c. Eltttia _j rtipontibla for elasticity, recoil properties F. Vhat it collagen? . Protein - 3 polypeptidet a. Triplet ttructure | ^aoetly hydroxyproline uau. proline b. Hydroxyproline - alaoat entirely within collttin. Goad aarkar for collagen eyntheeia. Important in stabilizing triple helix 2. Three polypeptides associate Increeellulerly - triple helix. Triple helix protein associate extraeellularly to fibril. 3. Different type* of collagen! I. Four to fire types . Vary la location, ttructural quailtitt, synthetic call, extractedility b. Alao differ in hlatochenieal staining propartiat - affect quantitation c. Altarationt is eollagaa ratios in cartala diseases. H. How la collagen aada? 1. Pro a-chaia made on riboeoaas 2. Hydroxy1Cion of pro lya * pro- achaln --with I tarminal and C terminal axcantion papeida 3. a chains aligned - triple helix 4. Clyooeylatioo. Sugar residues recess for sacration 3. Clearage of and C tarniaal peptides 6. Cross-linking -- hysroxylyslaa residues eroaa-linked through dasaosise cross links. Stabilises DUP 0933946 DU 036501 aBStBi;;; s. aiiaiBillK il.dk Aiaiaa .0 Introduction to Hachannaa of Fibrogantal* 3 A. Fibroganaiia i gantntlon of fibrosi# 3. How can vi influsncs amount of connaetiva tuiut aads? 1. Pocua oa fibroblaat - ilnci it ii sill rtaponaibia for scat of connaetiva tissua synthesis; located ia inceraticiun 2. Can f t of fibroblasts a. Sciaulata till prolifaration b. Attract son cill* into aria with chtmotactic facton 3. Can lynchtala of collagen par fibroblasts a. Can altar total oouat b. Can changa types of collagin made. Will affact atlffnata of luofl 4. Relevant aacb. - depends oa agsnt animal modal possible boat factora III. Mechaniems Tf Fibrogenasla A. Stimulation of fibroblaat prolifaratioo I. Claaaic example - itimulatioa of fibroblaat prolifaratioo and coUagon synthesis by factors from ailiea-traatad macropbaiaa a. Kaerophige Ugaat eryet. aillea. Takas ia pbsgotomt, than phagoiyeoeoam b. Hambrana disruptad, lysosomal aoxyma ralaasa iatracallulsrly, damage to macropbaga c. Oamd sod dying macrophages. Release factors that stimulate fibroals d. trUaocs i. Quarts la vitro v. toxic to macropbaga. UM ralaasa, ate. il. Quarts axpoaad animsls - mtcropbsgss appasr oacrotic, impaired phagocytic ability lii> la vitro work (sot always eooeiatent). Taators from uparnseaot of guarts-trsatad aaeropbagaa or from disrupttd aacropbagaa - stimulate fibroblast prolif. sad/or coUtgas production. 0t7* 93jp<7 DU 036502 Siir IfritaSi imi iv. of diffusion thanbera :o (cca for factor* Jn vivo Macrophages Mactcphagea * SlOj ^ In chiabr v/iaai paraeabla neabrta* SIO.2 -Put into peritontiaa -Look for f^broala - avidenc* of flbroeia by microscopic enalyei* Other Pibrogeneeis factor! from Macrophage* 1. Wound healing - flbroalt important eeeponeat* of norael wound healini and acar foreation .2 Macrophaja derived gro*ih factor! 3. Interleukin I - Protein produced by aacrophagee, aa Ivephocyte activating factor or endogesoua pyrogen. Stlaulatea- lynphccytaa and flrboblaata. Produced In retponae to bacteria, vlruaea, etc. --Lysphocytas atlaulate Interleukin production and can enhance flbroele. May be important la bypereenaltivlty and graouloautoue dleeeae. Platelet derived growth factor. Injury caueea platelet to releaae various fectore - clotting factore, ehaaotactld factore end fibroblaat growth factor. Contact-inhibition aachaolsa 1. Herhanda-- proposed for agent* that cause great epithelial call destruction, a.g., blacayein (antlcencer drag), butylated hydroxytoluene <ISC, eaclnldant), paraquat (herbicide). --Tlhrohlaete ere released froa contact Inhibition of growth. 2. Kay also Involve destruction of baseeeat eeabrtne. 3. Other cowpoaaata of this reepooae a. Accompanied by inflanatloo t Polysorphooucleaneutrophlla (MS'*) 4 chaaotactic factors DUP 0933948 DU 036503 5, b. PbM'a - lacret* colititotat, could attaulaca eollagan aynthtala. Can cauaa acdocntiial, tplchalial changaa, in paraaabiilcy. Could tfftcc Ir.citicclon becvaan flbroblaaca * apithailal ctiia. --Kay b* oultlftctorlal. Aiftettd by cypt o Injuring agaat. i. Mechanism pf Jtiauiatlon of eollagan aynchaaia 1. KacropSagaa * SiO. product alaulatlng faccori 2. Collaganaaa 3. Changaa la typa eollagan ?. Cbaaocaeclc agaoea 1. Jlbronaetin. 2. Sltaeln darlYad paptldaa, 3. Colltgnn darlvad paptldaa - (rnla nf eallataoaaa?} 4. Alaoae all ehaaa acudlaa la rltro;aaad to look for praaanea of faetora In vivo. DU? 0933949 DU 036504